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Compile Data Set for Download or QSAR

Found 171 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50004051
PNG
(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Show SMILES NC(CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
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n/an/an/an/a 280n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Metabotropic glutamate receptor 6


J Med Chem 41: 1641-50 (1998)


Article DOI: 10.1021/jm970719q
BindingDB Entry DOI: 10.7270/Q27945BZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50074749
PNG
((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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n/an/an/an/a 401n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human mGluR6


J Med Chem 42: 1027-40 (1999)


Article DOI: 10.1021/jm980616n
BindingDB Entry DOI: 10.7270/Q2WM1CKF
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434137
PNG
(CHEMBL2381649)
Show SMILES CC(=O)N[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1/C10H14N2O5/c1-3(13)12-4-2-10(11,9(16)17)7-5(4)6(7)8(14)15/h4-7H,2,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t4-,5-,6-,7-,10-/s2
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n/an/an/an/a 709n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255435
PNG
(CHEMBL4101970)
Show SMILES N[C@@H](CCP(O)(=O)[C@H](O)c1cc(F)c(O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14FN2O8P/c12-6-3-5(4-8(9(6)15)14(19)20)11(18)23(21,22)2-1-7(13)10(16)17/h3-4,7,11,15,18H,1-2,13H2,(H,16,17)(H,21,22)/t7-,11-/s2
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n/an/an/an/a 760n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434131
PNG
(CHEMBL2381644)
Show SMILES N[C@]1(C[C@@H](N=[N+]=[N-])[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C8H10N4O4/c9-8(7(15)16)1-2(11-12-10)3-4(5(3)8)6(13)14/h2-5H,1,9H2,(H,13,14)(H,15,16)/t2-,3+,4+,5+,8+/s2
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n/an/an/an/a 780n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/s2
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255407
PNG
(CHEMBL4077705)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cc(F)c(O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14FN2O8P/c12-6-3-5(4-8(9(6)15)14(19)20)11(18)23(21,22)2-1-7(13)10(16)17/h3-4,7,11,15,18H,1-2,13H2,(H,16,17)(H,21,22)/t7-,11?/s2
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n/an/an/an/a 1.07E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255347
PNG
(CHEMBL4081842)
Show SMILES COc1cc(cc(c1O)[N+]([O-])=O)[C@@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O9P/c1-23-9-5-6(4-8(10(9)15)14(19)20)12(18)24(21,22)3-2-7(13)11(16)17/h4-5,7,12,15,18H,2-3,13H2,1H3,(H,16,17)(H,21,22)/t7-,12-/s2
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434139
PNG
(CHEMBL2381650)
Show SMILES N[C@]1(C[C@@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9+,10+,11+,14+/s2
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n/an/an/an/a 1.27E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434135
PNG
(CHEMBL2381652)
Show SMILES N[C@]1(C[C@@H](F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C8H10FNO4/c9-2-1-8(10,7(13)14)5-3(2)4(5)6(11)12/h2-5H,1,10H2,(H,11,12)(H,13,14)/t2-,3+,4+,5+,8+/s2
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n/an/an/an/a 1.41E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50446782
PNG
(CHEMBL3114672)
Show SMILES COc1cc(cc(c1O)[N+]([O-])=O)C(=O)P(O)(O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O9P/c1-23-9-5-6(4-8(10(9)15)14(19)20)12(18)24(21,22)3-2-7(13)11(16)17/h4-5,7,15,21-22,24H,2-3,13H2,1H3,(H,16,17)/t7-/s2
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n/an/an/an/a 1.70E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50217031
PNG
((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m0/s1
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n/an/an/an/a 1.95E+3n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50244219
PNG
(CHEMBL4081453)
Show SMILES COc1cccc(c1)C(=O)N[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1/C16H18N2O6/c1-24-8-4-2-3-7(5-8)13(19)18-9-6-16(17,15(22)23)12-10(9)11(12)14(20)21/h2-5,9-12H,6,17H2,1H3,(H,18,19)(H,20,21)(H,22,23)/t9-,10-,11-,12-,16-/s2
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n/an/an/an/a 1.95E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in hamster AV12 cells co-expressing rat EAAT1 assessed as inhibition of forskolin-stimulated cAMP ...


J Med Chem 61: 2303-2328 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01481
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255348
PNG
(CHEMBL4085558)
Show SMILES COc1cc(cc(c1O)[N+]([O-])=O)[C@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O9P/c1-23-9-5-6(4-8(10(9)15)14(19)20)12(18)24(21,22)3-2-7(13)11(16)17/h4-5,7,12,15,18H,2-3,13H2,1H3,(H,16,17)(H,21,22)/t7-,12+/s2
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n/an/an/an/a 2.40E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/s2
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n/an/an/an/a 2.40E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255389
PNG
(CHEMBL4072781)
Show SMILES N[C@@H](CCP(O)(=O)[C@H](O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11-/s2
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n/an/an/an/a 2.40E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50074750
PNG
((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Show SMILES N[C@]1(CS[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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n/an/an/an/a 2.43E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human mGluR6


J Med Chem 42: 1027-40 (1999)


Article DOI: 10.1021/jm980616n
BindingDB Entry DOI: 10.7270/Q2WM1CKF
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255415
PNG
(CHEMBL4078629)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C12H14F3N2O7P/c13-12(14,15)7-5-6(1-2-9(7)17(21)22)11(20)25(23,24)4-3-8(16)10(18)19/h1-2,5,8,11,20H,3-4,16H2,(H,18,19)(H,23,24)/t8-,11?/s2
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n/an/an/an/a 2.90E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/s2
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n/an/an/an/a 2.99E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human mGluR6


J Med Chem 42: 1027-40 (1999)


Article DOI: 10.1021/jm980616n
BindingDB Entry DOI: 10.7270/Q2WM1CKF
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50138783
PNG
(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255336
PNG
(CHEMBL4064187)
Show SMILES N[C@@H](CCP(O)(=O)Cc1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O6P/c12-10(11(14)15)4-5-20(18,19)7-8-2-1-3-9(6-8)13(16)17/h1-3,6,10H,4-5,7,12H2,(H,14,15)(H,18,19)/t10-/s2
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n/an/an/an/a 3.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50446782
PNG
(CHEMBL3114672)
Show SMILES COc1cc(cc(c1O)[N+]([O-])=O)C(=O)P(O)(O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O9P/c1-23-9-5-6(4-8(10(9)15)14(19)20)12(18)24(21,22)3-2-7(13)11(16)17/h4-5,7,15,21-22,24H,2-3,13H2,1H3,(H,16,17)/t7-/s2
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n/an/an/an/a 3.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255437
PNG
(CHEMBL4085750)
Show SMILES N[C@@H](CCP(O)(=O)[C@@H](O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11+/s2
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n/an/an/an/a 3.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434138
PNG
(CHEMBL2381651)
Show SMILES N[C@]1(C[C@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9-,10-,11-,14-/s2
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n/an/an/an/a 3.25E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/s2
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n/an/an/an/a 3.36E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50217030
PNG
((1S,2S)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5+/m1/s1
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n/an/an/an/a 3.41E+3n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50121643
PNG
(CHEMBL3616847)
Show SMILES N[C@]1(C[C@@H](Sc2nnc[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,4+,5+,6+,10+/s2
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n/an/an/an/a 3.45E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant mGlu6 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...


J Med Chem 58: 7526-48 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01124
BindingDB Entry DOI: 10.7270/Q29S1ST0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255292
PNG
(CHEMBL4061423)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1csc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O7PS/c10-6(8(12)13)1-2-19(17,18)9(14)5-3-7(11(15)16)20-4-5/h3-4,6,9,14H,1-2,10H2,(H,12,13)(H,17,18)/t6-,9?/s2
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n/an/an/an/a 3.60E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255340
PNG
(CHEMBL4072316)
Show SMILES N[C@@H](CCP(O)(=O)[C@H](O)c1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O8P/c12-7(10(15)16)3-4-22(20,21)11(17)6-1-2-9(14)8(5-6)13(18)19/h1-2,5,7,11,14,17H,3-4,12H2,(H,15,16)(H,20,21)/t7-,11-/s2
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n/an/an/an/a 3.60E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255346
PNG
(CHEMBL4085327)
Show SMILES COc1ccc(cc1[N+]([O-])=O)[C@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O8P/c1-22-10-3-2-7(6-9(10)14(18)19)12(17)23(20,21)5-4-8(13)11(15)16/h2-3,6,8,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t8-,12+/s2
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n/an/an/an/a 3.90E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255403
PNG
(CHEMBL4101241)
Show SMILES Cc1ccc(cc1[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O7P/c1-7-2-3-8(6-10(7)14(18)19)12(17)22(20,21)5-4-9(13)11(15)16/h2-3,6,9,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t9-,12?/s2
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n/an/an/an/a 4.00E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255390
PNG
(CHEMBL4091029)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(F)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14FN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/s2
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n/an/an/an/a 4.00E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM196906
PNG
(US9212196, Derivative 2)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O
Show InChI InChI=1/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/s2
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n/an/an/an/a 4.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255397
PNG
(CHEMBL4090179)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(s1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O7PS/c10-5(8(12)13)3-4-19(17,18)9(14)6-1-2-7(20-6)11(15)16/h1-2,5,9,14H,3-4,10H2,(H,12,13)(H,17,18)/t5-,9?/s2
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n/an/an/an/a 4.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434132
PNG
(CHEMBL2381642)
Show SMILES N[C@]1(C[C@@H](O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C8H11NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3+,4+,5+,8+/s2
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n/an/an/an/a 4.37E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255342
PNG
(CHEMBL4063720)
Show SMILES COc1ccc(cc1[N+]([O-])=O)[C@@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O8P/c1-22-10-3-2-7(6-9(10)14(18)19)12(17)23(20,21)5-4-8(13)11(15)16/h2-3,6,8,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t8-,12-/s2
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n/an/an/an/a 4.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255406
PNG
(CHEMBL4088782)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)5-6-21(19,20)11(16)7-1-3-8(4-2-7)13(17)18/h1-4,9,11,16H,5-6,12H2,(H,14,15)(H,19,20)/t9-,11?/s2
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n/an/an/an/a 4.60E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 4.90E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Metabotropic glutamate receptor 6


J Med Chem 41: 1641-50 (1998)


Article DOI: 10.1021/jm970719q
BindingDB Entry DOI: 10.7270/Q27945BZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50064248
PNG
((1S,2S,4S,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dic...)
Show SMILES N[C@]1(C[C@@H]2C[C@H]1[C@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-3-1-4(8)5(3)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/an/an/a 5.30E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Metabotropic glutamate receptor 6


J Med Chem 41: 1641-50 (1998)


Article DOI: 10.1021/jm970719q
BindingDB Entry DOI: 10.7270/Q27945BZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50293743
PNG
(CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...)
Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
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n/an/an/an/a 5.36E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2WS8RPQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255337
PNG
(CHEMBL4063142)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(c(c1)[N+]([O-])=O)C(F)(F)F)C(O)=O
Show InChI InChI=1/C12H14F3N2O7P/c13-12(14,15)7-2-1-6(5-9(7)17(21)22)11(20)25(23,24)4-3-8(16)10(18)19/h1-2,5,8,11,20H,3-4,16H2,(H,18,19)(H,23,24)/t8-,11?/s2
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n/an/an/an/a 5.70E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255339
PNG
(CHEMBL4060360)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O8P/c12-7(10(15)16)3-4-22(20,21)11(17)6-1-2-9(14)8(5-6)13(18)19/h1-2,5,7,11,14,17H,3-4,12H2,(H,15,16)(H,20,21)/t7-,11?/s2
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n/an/an/an/a 6.00E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255396
PNG
(CHEMBL4067923)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(o1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O8P/c10-5(8(12)13)3-4-20(17,18)9(14)6-1-2-7(19-6)11(15)16/h1-2,5,9,14H,3-4,10H2,(H,12,13)(H,17,18)/t5-,9?/s2
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n/an/an/an/a 6.10E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255339
PNG
(CHEMBL4060360)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O8P/c12-7(10(15)16)3-4-22(20,21)11(17)6-1-2-9(14)8(5-6)13(18)19/h1-2,5,7,11,14,17H,3-4,12H2,(H,15,16)(H,20,21)/t7-,11?/s2
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n/an/an/an/a 6.30E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434140
PNG
(CHEMBL2381648)
Show SMILES CC(=O)N[C@@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1/C10H14N2O5/c1-3(13)12-4-2-10(11,9(16)17)7-5(4)6(7)8(14)15/h4-7H,2,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t4-,5+,6+,7+,10+/s2
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n/an/an/an/a 6.69E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/s2
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n/an/an/an/a 6.70E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50167032
PNG
((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Show SMILES C[C@@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
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n/an/an/an/a 7.54E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50255388
PNG
(CHEMBL4093492)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11?/s2
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n/an/an/an/a 8.80E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50167034
PNG
((1S,2S,4S,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Show SMILES C[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4-,5-,6-,9-/m0/s1
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n/an/an/an/a 9.28E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50434129
PNG
(CHEMBL2381647)
Show SMILES N[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1/C8H12N2O4/c9-2-1-8(10,7(13)14)5-3(2)4(5)6(11)12/h2-5H,1,9-10H2,(H,11,12)(H,13,14)/t2-,3-,4-,5-,8-/s2
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n/an/an/an/a 9.37E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
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