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Found 277 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 7'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283487
PNG
(CHEMBL4162576)
Show SMILES Clc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1
Show InChI InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
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n/an/an/an/a 146n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283478
PNG
(CHEMBL4164141)
Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3
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n/an/an/an/a 479n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283478
PNG
(CHEMBL4164141)
Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3
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n/an/an/an/a 480n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283489
PNG
(CHEMBL4168668)
Show SMILES COc1cc(F)c(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-12(16(19,20)21)24-15(22-7)13(8(2)23-24)14-10(17)5-9(25-3)6-11(14)18/h4-6H,1-3H3
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n/an/an/an/a 600n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283489
PNG
(CHEMBL4168668)
Show SMILES COc1cc(F)c(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-12(16(19,20)21)24-15(22-7)13(8(2)23-24)14-10(17)5-9(25-3)6-11(14)18/h4-6H,1-3H3
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n/an/an/an/a 603n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283472
PNG
(CHEMBL4160748)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
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n/an/an/an/a 646n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283472
PNG
(CHEMBL4160748)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
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n/an/an/an/a 650n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283481
PNG
(CHEMBL4160675)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1cc(F)c(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H12F7N3O/c1-3-11-14(8-5-10(19)12(6-9(8)18)28-16(20)21)15-25-7(2)4-13(17(22,23)24)27(15)26-11/h4-6,16H,3H2,1-2H3
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n/an/an/an/a 740n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283481
PNG
(CHEMBL4160675)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1cc(F)c(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H12F7N3O/c1-3-11-14(8-5-10(19)12(6-9(8)18)28-16(20)21)15-25-7(2)4-13(17(22,23)24)27(15)26-11/h4-6,16H,3H2,1-2H3
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n/an/an/an/a 741n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283490
PNG
(CHEMBL4172016)
Show SMILES COc1cc(F)c(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-11(18)12(25-3)6-10(9)17/h4-6H,1-3H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283490
PNG
(CHEMBL4172016)
Show SMILES COc1cc(F)c(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-11(18)12(25-3)6-10(9)17/h4-6H,1-3H3
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n/an/an/an/a 1.02E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283488
PNG
(CHEMBL4171274)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C17H14F5N3O/c1-4-10-13(9-5-6-11(26-3)15(19)14(9)18)16-23-8(2)7-12(17(20,21)22)25(16)24-10/h5-7H,4H2,1-3H3
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n/an/an/an/a 1.05E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283488
PNG
(CHEMBL4171274)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C17H14F5N3O/c1-4-10-13(9-5-6-11(26-3)15(19)14(9)18)16-23-8(2)7-12(17(20,21)22)25(16)24-10/h5-7H,4H2,1-3H3
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n/an/an/an/a 1.05E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 1.18E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP production


J Med Chem 59: 914-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01333
BindingDB Entry DOI: 10.7270/Q2000408
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283480
PNG
(CHEMBL4175784)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H13F6N3O/c1-3-12-14(10-5-4-9(7-11(10)18)27-16(19)20)15-24-8(2)6-13(17(21,22)23)26(15)25-12/h4-7,16H,3H2,1-2H3
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n/an/an/an/a 1.48E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283480
PNG
(CHEMBL4175784)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H13F6N3O/c1-3-12-14(10-5-4-9(7-11(10)18)27-16(19)20)15-24-8(2)6-13(17(21,22)23)26(15)25-12/h4-7,16H,3H2,1-2H3
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n/an/an/an/a 1.48E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283479
PNG
(CHEMBL4165248)
Show SMILES COc1ccc(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283491
PNG
(CHEMBL1585091)
Show SMILES COC(=O)c1ccc(cc1)-n1c(C)cc(C(=O)CSc2ccc(NC(C)=O)cc2)c1C
Show InChI InChI=1S/C24H24N2O4S/c1-15-13-22(16(2)26(15)20-9-5-18(6-10-20)24(29)30-4)23(28)14-31-21-11-7-19(8-12-21)25-17(3)27/h5-13H,14H2,1-4H3,(H,25,27)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283479
PNG
(CHEMBL4165248)
Show SMILES COc1ccc(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 1.51E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283484
PNG
(CHEMBL4175868)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)11-5-4-10(24-3)7-12(11)17/h4-7H,1-3H3
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n/an/an/an/a 1.66E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283485
PNG
(CHEMBL4161084)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)cc1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-4-13-15(11-5-7-12(24-3)8-6-11)16-21-10(2)9-14(17(18,19)20)23(16)22-13/h5-9H,4H2,1-3H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283484
PNG
(CHEMBL4175868)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)11-5-4-10(24-3)7-12(11)17/h4-7H,1-3H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283485
PNG
(CHEMBL4161084)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)cc1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-4-13-15(11-5-7-12(24-3)8-6-11)16-21-10(2)9-14(17(18,19)20)23(16)22-13/h5-9H,4H2,1-3H3
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n/an/an/an/a 1.74E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196924
PNG
(US9212196, Derivative 20)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(OC(F)(F)F)c1)C(O)=O
Show InChI InChI=1/C14H17F3NO9P/c15-14(16,17)27-10-5-7(1-2-9(10)26-6-11(19)20)13(23)28(24,25)4-3-8(18)12(21)22/h1-2,5,8,13,23H,3-4,6,18H2,(H,19,20)(H,21,22)(H,24,25)/t8-,13?/s2
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US Patent
n/an/an/an/a 1.97E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283482
PNG
(CHEMBL4172374)
Show SMILES COc1ccc(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13ClF3N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 2.29E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283482
PNG
(CHEMBL4172374)
Show SMILES COc1ccc(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13ClF3N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 2.30E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283493
PNG
(CHEMBL4164496)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-8-7-12(16(19,20)21)24-14(22-8)13(9(2)23-24)10-3-5-11(6-4-10)25-15(17)18/h3-7,15H,1-2H3
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n/an/an/an/a 2.75E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283493
PNG
(CHEMBL4164496)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-8-7-12(16(19,20)21)24-14(22-8)13(9(2)23-24)10-3-5-11(6-4-10)25-15(17)18/h3-7,15H,1-2H3
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n/an/an/an/a 2.80E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50358179
PNG
(CHEMBL1921961)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,27-28H,9H2,(H,24,26)/t11-,12+
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n/an/an/an/a 2.90E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu7 receptor at 10 uM by thallium flux assay


J Med Chem 54: 7639-47 (2011)


Article DOI: 10.1021/jm200956q
BindingDB Entry DOI: 10.7270/Q25Q4WHD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283477
PNG
(CHEMBL4169009)
Show SMILES COc1ccc(cc1C)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-9-7-12(5-6-13(9)24-4)15-11(3)22-23-14(17(18,19)20)8-10(2)21-16(15)23/h5-8H,1-4H3
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n/an/an/an/a 2.95E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283477
PNG
(CHEMBL4169009)
Show SMILES COc1ccc(cc1C)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-9-7-12(5-6-13(9)24-4)15-11(3)22-23-14(17(18,19)20)8-10(2)21-16(15)23/h5-8H,1-4H3
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n/an/an/an/a 3.00E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283483
PNG
(CHEMBL2361777)
Show SMILES COc1ccc(cc1)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-8-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-4-6-12(23-3)7-5-11/h4-8H,1-3H3
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n/an/an/an/a 3.30E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283483
PNG
(CHEMBL2361777)
Show SMILES COc1ccc(cc1)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-8-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-4-6-12(23-3)7-5-11/h4-8H,1-3H3
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n/an/an/an/a 3.31E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196910
PNG
(US9212196, Derivative 6)
Show SMILES COc1cc(cc(F)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H19FNO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/s2
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n/an/an/an/a 3.50E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196932
PNG
(US9212196, Derivative 28)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1cc(F)c(OCC(O)=O)c(F)c1)C(O)=O
Show InChI InChI=1/C13H16F2NO8P/c14-7-3-6(4-8(15)11(7)24-5-10(17)18)13(21)25(22,23)2-1-9(16)12(19)20/h3-4,9,13,21H,1-2,5,16H2,(H,17,18)(H,19,20)(H,22,23)/t9-,13?/s2
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n/an/an/an/a 3.87E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50393322
PNG
(CHEMBL2152119)
Show SMILES O[C@H]1CC[C@@H](CC1)n1ccc2cc(ccc12)-c1ccn2c(CC(F)(F)F)cnc2c1Cl
Show InChI InChI=1/C23H21ClF3N3O/c24-21-19(8-10-30-17(12-23(25,26)27)13-28-22(21)30)14-1-6-20-15(11-14)7-9-29(20)16-2-4-18(31)5-3-16/h1,6-11,13,16,18,31H,2-5,12H2/t16-,18-
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n/an/an/an/a 5.20E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu 7 expressed in HEK293 cells by Ca+2 assay


J Med Chem 55: 2688-701 (2012)


Article DOI: 10.1021/jm201561r
BindingDB Entry DOI: 10.7270/Q2SN0B2B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196912
PNG
(US9212196, Derivative 8)
Show SMILES COc1cc(cc(I)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H19INO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/s2
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n/an/an/an/a 6.60E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50392432
PNG
(CHEMBL2151817)
Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C(C)(C)C
Show InChI InChI=1/C19H23FN2O2/c1-13(19(2,3)4)22-18(23)15-8-9-17(21-11-15)24-12-14-6-5-7-16(20)10-14/h5-11,13H,12H2,1-4H3,(H,22,23)/t13-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of mGluR7


Bioorg Med Chem Lett 22: 6481-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.043
BindingDB Entry DOI: 10.7270/Q2KD200S
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50353292
PNG
(CHEMBL1830698)
Show SMILES C1Cc2sc(Nc3ccccn3)nc2-c2cn[nH]c12
Show InChI InChI=1S/C13H11N5S/c1-2-6-14-11(3-1)16-13-17-12-8-7-15-18-9(8)4-5-10(12)19-13/h1-3,6-7H,4-5H2,(H,15,18)(H,14,16,17)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of mGlu7 receptor assessed as potentiation of glutamate-induced calcium mobilization


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50337525
PNG
(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Show SMILES O=C1CCOc2cc(COc3ccccc3)ccc12
Show InChI InChI=1S/C16H14O3/c17-15-8-9-18-16-10-12(6-7-14(15)16)11-19-13-4-2-1-3-5-13/h1-7,10H,8-9,11H2
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assay


J Med Chem 56: 7243-59 (2013)


Article DOI: 10.1021/jm400650w
BindingDB Entry DOI: 10.7270/Q2F19152
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50440205
PNG
(CHEMBL2426621)
Show SMILES O=C1CCCc2nc(sc12)C#Cc1ccccc1
Show InChI InChI=1S/C15H11NOS/c17-13-8-4-7-12-15(13)18-14(16-12)10-9-11-5-2-1-3-6-11/h1-3,5-6H,4,7-8H2
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assay


J Med Chem 56: 7243-59 (2013)


Article DOI: 10.1021/jm400650w
BindingDB Entry DOI: 10.7270/Q2F19152
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50440185
PNG
(CHEMBL2426616)
Show SMILES CN1CCc2nc(COc3ccccc3)sc2C1=O
Show InChI InChI=1S/C14H14N2O2S/c1-16-8-7-11-13(14(16)17)19-12(15-11)9-18-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assay


J Med Chem 56: 7243-59 (2013)


Article DOI: 10.1021/jm400650w
BindingDB Entry DOI: 10.7270/Q2F19152
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM49388
PNG
(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | 7-ben...)
Show SMILES O=C1CCOc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C16H14O3/c17-15-8-9-18-16-10-13(6-7-14(15)16)19-11-12-4-2-1-3-5-12/h1-7,10H,8-9,11H2
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assay


J Med Chem 56: 7243-59 (2013)


Article DOI: 10.1021/jm400650w
BindingDB Entry DOI: 10.7270/Q2F19152
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis


Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis


Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50132507
PNG
(CHEMBL3633943)
Show SMILES CC(=O)N1CCCn2nc(COc3ccccc3)cc12
Show InChI InChI=1S/C15H17N3O2/c1-12(19)17-8-5-9-18-15(17)10-13(16-18)11-20-14-6-3-2-4-7-14/h2-4,6-7,10H,5,8-9,11H2,1H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
In vitro binding affinity for PPAR-gamma


Bioorg Med Chem Lett 25: 5115-20 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.009
BindingDB Entry DOI: 10.7270/Q2445P80
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50064444
PNG
(CHEMBL3401195)
Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3ccccc3)cn2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-6-8-16(9-7-14)22-11-10-18-21-15(12-23(18)19(22)24)13-25-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR7 (unknown origin)


Bioorg Med Chem Lett 25: 1310-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.038
BindingDB Entry DOI: 10.7270/Q2057HNQ
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50064463
PNG
(CHEMBL3401177)
Show SMILES Fc1ccc(cc1)-n1ccc2nc(COc3ccccc3)cn2c1=O
Show InChI InChI=1S/C19H14FN3O2/c20-14-6-8-16(9-7-14)22-11-10-18-21-15(12-23(18)19(22)24)13-25-17-4-2-1-3-5-17/h1-12H,13H2
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR7 (unknown origin)


Bioorg Med Chem Lett 25: 1310-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.038
BindingDB Entry DOI: 10.7270/Q2057HNQ
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50353290
PNG
(CHEMBL1830707)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ccccn3)sc2C1
Show InChI InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of mGlu7 receptor assessed as potentiation of glutamate-induced calcium mobilization


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
GRM7


(Homo sapiens (Human))
BDBM50353291
PNG
(CHEMBL1830711)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1
Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of mGlu7 receptor assessed as potentiation of glutamate-induced calcium mobilization


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
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