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Found 147 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 7 (mGlu7)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283487
PNG
(CHEMBL4162576)
Show SMILES Clc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1
Show InChI InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
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n/an/an/an/a 146n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283478
PNG
(CHEMBL4164141)
Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3
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n/an/an/an/a 479n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283478
PNG
(CHEMBL4164141)
Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3
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n/an/an/an/a 480n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283489
PNG
(CHEMBL4168668)
Show SMILES COc1cc(F)c(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-12(16(19,20)21)24-15(22-7)13(8(2)23-24)14-10(17)5-9(25-3)6-11(14)18/h4-6H,1-3H3
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n/an/an/an/a 600n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283489
PNG
(CHEMBL4168668)
Show SMILES COc1cc(F)c(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-12(16(19,20)21)24-15(22-7)13(8(2)23-24)14-10(17)5-9(25-3)6-11(14)18/h4-6H,1-3H3
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n/an/an/an/a 603n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283472
PNG
(CHEMBL4160748)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
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n/an/an/an/a 646n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283472
PNG
(CHEMBL4160748)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
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n/an/an/an/a 650n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283481
PNG
(CHEMBL4160675)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1cc(F)c(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H12F7N3O/c1-3-11-14(8-5-10(19)12(6-9(8)18)28-16(20)21)15-25-7(2)4-13(17(22,23)24)27(15)26-11/h4-6,16H,3H2,1-2H3
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n/an/an/an/a 740n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283481
PNG
(CHEMBL4160675)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1cc(F)c(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H12F7N3O/c1-3-11-14(8-5-10(19)12(6-9(8)18)28-16(20)21)15-25-7(2)4-13(17(22,23)24)27(15)26-11/h4-6,16H,3H2,1-2H3
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n/an/an/an/a 741n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283490
PNG
(CHEMBL4172016)
Show SMILES COc1cc(F)c(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-11(18)12(25-3)6-10(9)17/h4-6H,1-3H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283490
PNG
(CHEMBL4172016)
Show SMILES COc1cc(F)c(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-11(18)12(25-3)6-10(9)17/h4-6H,1-3H3
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n/an/an/an/a 1.02E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283488
PNG
(CHEMBL4171274)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C17H14F5N3O/c1-4-10-13(9-5-6-11(26-3)15(19)14(9)18)16-23-8(2)7-12(17(20,21)22)25(16)24-10/h5-7H,4H2,1-3H3
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n/an/an/an/a 1.05E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283488
PNG
(CHEMBL4171274)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C17H14F5N3O/c1-4-10-13(9-5-6-11(26-3)15(19)14(9)18)16-23-8(2)7-12(17(20,21)22)25(16)24-10/h5-7H,4H2,1-3H3
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n/an/an/an/a 1.05E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283480
PNG
(CHEMBL4175784)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H13F6N3O/c1-3-12-14(10-5-4-9(7-11(10)18)27-16(19)20)15-24-8(2)6-13(17(21,22)23)26(15)25-12/h4-7,16H,3H2,1-2H3
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n/an/an/an/a 1.48E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283480
PNG
(CHEMBL4175784)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C17H13F6N3O/c1-3-12-14(10-5-4-9(7-11(10)18)27-16(19)20)15-24-8(2)6-13(17(21,22)23)26(15)25-12/h4-7,16H,3H2,1-2H3
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n/an/an/an/a 1.48E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283491
PNG
(CHEMBL1585091)
Show SMILES COC(=O)c1ccc(cc1)-n1c(C)cc(C(=O)CSc2ccc(NC(C)=O)cc2)c1C
Show InChI InChI=1S/C24H24N2O4S/c1-15-13-22(16(2)26(15)20-9-5-18(6-10-20)24(29)30-4)23(28)14-31-21-11-7-19(8-12-21)25-17(3)27/h5-13H,14H2,1-4H3,(H,25,27)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283479
PNG
(CHEMBL4165248)
Show SMILES COc1ccc(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283479
PNG
(CHEMBL4165248)
Show SMILES COc1ccc(cc1F)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 1.51E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283484
PNG
(CHEMBL4175868)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)11-5-4-10(24-3)7-12(11)17/h4-7H,1-3H3
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n/an/an/an/a 1.66E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283485
PNG
(CHEMBL4161084)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)cc1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-4-13-15(11-5-7-12(24-3)8-6-11)16-21-10(2)9-14(17(18,19)20)23(16)22-13/h5-9H,4H2,1-3H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283484
PNG
(CHEMBL4175868)
Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C16H13F4N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)11-5-4-10(24-3)7-12(11)17/h4-7H,1-3H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283485
PNG
(CHEMBL4161084)
Show SMILES CCc1nn2c(cc(C)nc2c1-c1ccc(OC)cc1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-4-13-15(11-5-7-12(24-3)8-6-11)16-21-10(2)9-14(17(18,19)20)23(16)22-13/h5-9H,4H2,1-3H3
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n/an/an/an/a 1.74E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196924
PNG
(US9212196, Derivative 20)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(OC(F)(F)F)c1)C(O)=O
Show InChI InChI=1/C14H17F3NO9P/c15-14(16,17)27-10-5-7(1-2-9(10)26-6-11(19)20)13(23)28(24,25)4-3-8(18)12(21)22/h1-2,5,8,13,23H,3-4,6,18H2,(H,19,20)(H,21,22)(H,24,25)/t8-,13?/s2
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US Patent
n/an/an/an/a 1.97E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283482
PNG
(CHEMBL4172374)
Show SMILES COc1ccc(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13ClF3N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 2.29E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283482
PNG
(CHEMBL4172374)
Show SMILES COc1ccc(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H13ClF3N3O/c1-8-6-13(16(18,19)20)23-15(21-8)14(9(2)22-23)10-4-5-12(24-3)11(17)7-10/h4-7H,1-3H3
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n/an/an/an/a 2.30E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283493
PNG
(CHEMBL4164496)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-8-7-12(16(19,20)21)24-14(22-8)13(9(2)23-24)10-3-5-11(6-4-10)25-15(17)18/h3-7,15H,1-2H3
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n/an/an/an/a 2.75E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283493
PNG
(CHEMBL4164496)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccc(OC(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F5N3O/c1-8-7-12(16(19,20)21)24-14(22-8)13(9(2)23-24)10-3-5-11(6-4-10)25-15(17)18/h3-7,15H,1-2H3
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n/an/an/an/a 2.80E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50358179
PNG
(CHEMBL1921961)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,27-28H,9H2,(H,24,26)/t11-,12+
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n/an/an/an/a 2.90E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu7 receptor at 10 uM by thallium flux assay


J Med Chem 54: 7639-47 (2011)


Article DOI: 10.1021/jm200956q
BindingDB Entry DOI: 10.7270/Q25Q4WHD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283477
PNG
(CHEMBL4169009)
Show SMILES COc1ccc(cc1C)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-9-7-12(5-6-13(9)24-4)15-11(3)22-23-14(17(18,19)20)8-10(2)21-16(15)23/h5-8H,1-4H3
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n/an/an/an/a 2.95E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283477
PNG
(CHEMBL4169009)
Show SMILES COc1ccc(cc1C)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-9-7-12(5-6-13(9)24-4)15-11(3)22-23-14(17(18,19)20)8-10(2)21-16(15)23/h5-8H,1-4H3
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n/an/an/an/a 3.00E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283483
PNG
(CHEMBL2361777)
Show SMILES COc1ccc(cc1)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-8-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-4-6-12(23-3)7-5-11/h4-8H,1-3H3
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n/an/an/an/a 3.30E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283483
PNG
(CHEMBL2361777)
Show SMILES COc1ccc(cc1)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-8-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-4-6-12(23-3)7-5-11/h4-8H,1-3H3
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n/an/an/an/a 3.31E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196910
PNG
(US9212196, Derivative 6)
Show SMILES COc1cc(cc(F)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H19FNO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/s2
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n/an/an/an/a 3.50E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196932
PNG
(US9212196, Derivative 28)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1cc(F)c(OCC(O)=O)c(F)c1)C(O)=O
Show InChI InChI=1/C13H16F2NO8P/c14-7-3-6(4-8(15)11(7)24-5-10(17)18)13(21)25(22,23)2-1-9(16)12(19)20/h3-4,9,13,21H,1-2,5,16H2,(H,17,18)(H,19,20)(H,22,23)/t9-,13?/s2
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n/an/an/an/a 3.87E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196912
PNG
(US9212196, Derivative 8)
Show SMILES COc1cc(cc(I)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H19INO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/s2
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n/an/an/an/a 6.60E+3n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283486
PNG
(CHEMBL4161818)
Show SMILES COc1ccccc1-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-8-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-6-4-5-7-12(11)23-3/h4-8H,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283492
PNG
(CHEMBL4165644)
Show SMILES COc1cccc(c1)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-7-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-5-4-6-12(8-11)23-3/h4-8H,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283486
PNG
(CHEMBL4161818)
Show SMILES COc1ccccc1-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-8-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-6-4-5-7-12(11)23-3/h4-8H,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50022759
PNG
(CHEMBL3298273)
Show SMILES Fc1cccc(COc2ccc3C(=O)NCCc3n2)c1
Show InChI InChI=1S/C15H13FN2O2/c16-11-3-1-2-10(8-11)9-20-14-5-4-12-13(18-14)6-7-17-15(12)19/h1-5,8H,6-7,9H2,(H,17,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu7 receptor expressed in HEK293 cells assessed as L-AP4-induced GIRK channel-mediated thallium flux ...


J Med Chem 57: 5620-37 (2014)


Article DOI: 10.1021/jm500259z
BindingDB Entry DOI: 10.7270/Q2736SHB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50283492
PNG
(CHEMBL4165644)
Show SMILES COc1cccc(c1)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-9-7-13(16(17,18)19)22-15(20-9)14(10(2)21-22)11-5-4-6-12(8-11)23-3/h4-8H,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50116515
PNG
(CHEMBL3609729)
Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...


ACS Med Chem Lett 8: 1110-1115 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196928
PNG
(US9212196, Derivative 24)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C13H17N2O10P/c14-8(12(18)19)3-4-26(23,24)13(20)7-1-2-10(25-6-11(16)17)9(5-7)15(21)22/h1-2,5,8,13,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,23,24)/t8-,13?/s2
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n/an/an/an/a 1.12E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196911
PNG
(US9212196, Derivative 7)
Show SMILES COc1cc(cc(Cl)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H19ClNO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/s2
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n/an/an/an/a 1.14E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196907
PNG
(US9212196, Derivative 3)
Show SMILES COc1cc(ccc1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H20NO9P/c1-23-11-6-8(2-3-10(11)24-7-12(16)17)14(20)25(21,22)5-4-9(15)13(18)19/h2-3,6,9,14,20H,4-5,7,15H2,1H3,(H,16,17)(H,18,19)(H,21,22)/t9-,14?/s2
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n/an/an/an/a 1.15E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196906
PNG
(US9212196, Derivative 2)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O
Show InChI InChI=1/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/s2
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n/an/an/an/a 1.16E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196930
PNG
(US9212196, Derivative 26)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(SCC(O)=O)cc1)C(O)=O
Show InChI InChI=1/C13H18NO7PS/c14-10(12(17)18)5-6-22(20,21)13(19)8-1-3-9(4-2-8)23-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/s2
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n/an/an/an/a 1.30E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196926
PNG
(US9212196, Derivative 22)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(O)c1)C(O)=O
Show InChI InChI=1/C13H18NO9P/c14-8(12(18)19)3-4-24(21,22)13(20)7-1-2-10(9(15)5-7)23-6-11(16)17/h1-2,5,8,13,15,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,21,22)/t8-,13?/s2
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n/an/an/an/a 1.50E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196929
PNG
(US9212196, Derivative 25)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(SCC(O)=O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C13H17N2O9PS/c14-8(12(18)19)3-4-25(23,24)13(20)7-1-2-10(26-6-11(16)17)9(5-7)15(21)22/h1-2,5,8,13,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,23,24)/t8-,13?/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.52E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196936
PNG
(US9212196, Derivative 32)
Show SMILES N[C@H](CCP(O)(=O)Cc1ccc(OCC(O)=O)c(OC(F)(F)F)c1)C(O)=O
Show InChI InChI=1/C14H17F3NO8P/c15-14(16,17)26-11-5-8(1-2-10(11)25-6-12(19)20)7-27(23,24)4-3-9(18)13(21)22/h1-2,5,9H,3-4,6-7,18H2,(H,19,20)(H,21,22)(H,23,24)/t9-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.62E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196913
PNG
(US9212196, Derivative 9)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1cc(Cl)c(OCC(O)=O)c(Cl)c1)C(O)=O
Show InChI InChI=1/C13H16Cl2NO8P/c14-7-3-6(4-8(15)11(7)24-5-10(17)18)13(21)25(22,23)2-1-9(16)12(19)20/h3-4,9,13,21H,1-2,5,16H2,(H,17,18)(H,19,20)(H,22,23)/t9-,13?/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.29E+4n/an/an/an/a



Universite Paris Descartes

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
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