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Compile Data Set for Download or QSAR

Found 95 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 7 (mGlu7)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196924
PNG
(US9212196, Derivative 20)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(OC(F)(F)F)c1)C(O)=O
Show InChI InChI=1S/C14H17F3NO9P/c15-14(16,17)27-10-5-7(1-2-9(10)26-6-11(19)20)13(23)28(24,25)4-3-8(18)12(21)22/h1-2,5,8,13,23H,3-4,6,18H2,(H,19,20)(H,21,22)(H,24,25)/t8-,13?/m1/s1
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n/an/an/an/a 1.97E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50358179
PNG
(CHEMBL1921961)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,27-28H,9H2,(H,24,26)/t11-,12+
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n/an/an/an/a 2.90E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu7 receptor at 10 uM by thallium flux assay


J Med Chem 54: 7639-47 (2011)


Article DOI: 10.1021/jm200956q
BindingDB Entry DOI: 10.7270/Q25Q4WHD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196910
PNG
(US9212196, Derivative 6)
Show SMILES COc1cc(cc(F)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C14H19FNO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/m1/s1
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n/an/an/an/a 3.50E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196932
PNG
(US9212196, Derivative 28)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1cc(F)c(OCC(O)=O)c(F)c1)C(O)=O
Show InChI InChI=1S/C13H16F2NO8P/c14-7-3-6(4-8(15)11(7)24-5-10(17)18)13(21)25(22,23)2-1-9(16)12(19)20/h3-4,9,13,21H,1-2,5,16H2,(H,17,18)(H,19,20)(H,22,23)/t9-,13?/m1/s1
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n/an/an/an/a 3.87E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196912
PNG
(US9212196, Derivative 8)
Show SMILES COc1cc(cc(I)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C14H19INO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/m1/s1
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n/an/an/an/a 6.60E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50022759
PNG
(CHEMBL3298273)
Show SMILES Fc1cccc(COc2ccc3C(=O)NCCc3n2)c1
Show InChI InChI=1S/C15H13FN2O2/c16-11-3-1-2-10(8-11)9-20-14-5-4-12-13(18-14)6-7-17-15(12)19/h1-5,8H,6-7,9H2,(H,17,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu7 receptor expressed in HEK293 cells assessed as L-AP4-induced GIRK channel-mediated thallium flux ...


J Med Chem 57: 5620-37 (2014)


Article DOI: 10.1021/jm500259z
BindingDB Entry DOI: 10.7270/Q2736SHB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196928
PNG
(US9212196, Derivative 24)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C13H17N2O10P/c14-8(12(18)19)3-4-26(23,24)13(20)7-1-2-10(25-6-11(16)17)9(5-7)15(21)22/h1-2,5,8,13,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,23,24)/t8-,13?/m1/s1
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n/an/an/an/a 1.12E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196911
PNG
(US9212196, Derivative 7)
Show SMILES COc1cc(cc(Cl)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C14H19ClNO9P/c1-24-10-5-7(4-8(15)12(10)25-6-11(17)18)14(21)26(22,23)3-2-9(16)13(19)20/h4-5,9,14,21H,2-3,6,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t9-,14?/m1/s1
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n/an/an/an/a 1.14E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196907
PNG
(US9212196, Derivative 3)
Show SMILES COc1cc(ccc1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C14H20NO9P/c1-23-11-6-8(2-3-10(11)24-7-12(16)17)14(20)25(21,22)5-4-9(15)13(18)19/h2-3,6,9,14,20H,4-5,7,15H2,1H3,(H,16,17)(H,18,19)(H,21,22)/t9-,14?/m1/s1
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n/an/an/an/a 1.15E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196906
PNG
(US9212196, Derivative 2)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O
Show InChI InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1
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n/an/an/an/a 1.16E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196930
PNG
(US9212196, Derivative 26)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(SCC(O)=O)cc1)C(O)=O
Show InChI InChI=1S/C13H18NO7PS/c14-10(12(17)18)5-6-22(20,21)13(19)8-1-3-9(4-2-8)23-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m1/s1
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n/an/an/an/a 1.30E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196926
PNG
(US9212196, Derivative 22)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C13H18NO9P/c14-8(12(18)19)3-4-24(21,22)13(20)7-1-2-10(9(15)5-7)23-6-11(16)17/h1-2,5,8,13,15,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,21,22)/t8-,13?/m1/s1
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n/an/an/an/a 1.50E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196929
PNG
(US9212196, Derivative 25)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(SCC(O)=O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C13H17N2O9PS/c14-8(12(18)19)3-4-25(23,24)13(20)7-1-2-10(26-6-11(16)17)9(5-7)15(21)22/h1-2,5,8,13,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,23,24)/t8-,13?/m1/s1
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n/an/an/an/a 1.52E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196936
PNG
(US9212196, Derivative 32)
Show SMILES N[C@H](CCP(O)(=O)Cc1ccc(OCC(O)=O)c(OC(F)(F)F)c1)C(O)=O
Show InChI InChI=1S/C14H17F3NO8P/c15-14(16,17)26-11-5-8(1-2-10(11)25-6-12(19)20)7-27(23,24)4-3-9(18)13(21)22/h1-2,5,9H,3-4,6-7,18H2,(H,19,20)(H,21,22)(H,23,24)/t9-/m1/s1
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n/an/an/an/a 1.62E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196913
PNG
(US9212196, Derivative 9)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1cc(Cl)c(OCC(O)=O)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C13H16Cl2NO8P/c14-7-3-6(4-8(15)11(7)24-5-10(17)18)13(21)25(22,23)2-1-9(16)12(19)20/h3-4,9,13,21H,1-2,5,16H2,(H,17,18)(H,19,20)(H,22,23)/t9-,13?/m1/s1
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n/an/an/an/a 2.29E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50398743
PNG
(CHEMBL2179631)
Show SMILES COc1ccc(cc1-c1cccc(COc2ccc3C(=O)N(Cc3c2)C2CCCC2)c1)C(O)=O
Show InChI InChI=1S/C28H27NO5/c1-33-26-12-9-20(28(31)32)15-25(26)19-6-4-5-18(13-19)17-34-23-10-11-24-21(14-23)16-29(27(24)30)22-7-2-3-8-22/h4-6,9-15,22H,2-3,7-8,16-17H2,1H3,(H,31,32)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay


J Med Chem 55: 9434-45 (2012)


Article DOI: 10.1021/jm3005306
BindingDB Entry DOI: 10.7270/Q2RX9D78
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50398744
PNG
(CHEMBL2179629)
Show SMILES OC(=O)c1cc(ccc1Cl)-c1cccc(COc2ccc3c(c2)sn(C2CC2)c3=O)c1
Show InChI InChI=1S/C24H18ClNO4S/c25-21-9-4-16(11-20(21)24(28)29)15-3-1-2-14(10-15)13-30-18-7-8-19-22(12-18)31-26(23(19)27)17-5-6-17/h1-4,7-12,17H,5-6,13H2,(H,28,29)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay


J Med Chem 55: 9434-45 (2012)


Article DOI: 10.1021/jm3005306
BindingDB Entry DOI: 10.7270/Q2RX9D78
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196918
PNG
(US9212196, Derivative 14)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCP(O)(O)=O)cc1)C(O)=O
Show InChI InChI=1S/C12H19NO9P2/c13-10(11(14)15)5-6-23(17,18)12(16)8-1-3-9(4-2-8)22-7-24(19,20)21/h1-4,10,12,16H,5-7,13H2,(H,14,15)(H,17,18)(H2,19,20,21)/t10-,12?/m1/s1
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n/an/an/an/a 3.40E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196925
PNG
(US9212196, Derivative 21)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C14H17F3NO8P/c15-14(16,17)8-5-7(1-2-10(8)26-6-11(19)20)13(23)27(24,25)4-3-9(18)12(21)22/h1-2,5,9,13,23H,3-4,6,18H2,(H,19,20)(H,21,22)(H,24,25)/t9-,13?/m1/s1
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n/an/an/an/a 3.55E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196916
PNG
(US9212196, Derivative 12)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(CCC(O)=O)cc1)C(O)=O
Show InChI InChI=1S/C14H20NO7P/c15-11(13(18)19)7-8-23(21,22)14(20)10-4-1-9(2-5-10)3-6-12(16)17/h1-2,4-5,11,14,20H,3,6-8,15H2,(H,16,17)(H,18,19)(H,21,22)/t11-,14?/m1/s1
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n/an/an/an/a 3.70E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50034503
PNG
((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
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n/an/an/an/a 4.00E+4n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 antagonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50314796
PNG
((3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...)
Show SMILES OC(=O)CCP(O)(=O)CCC(=N)C(O)=O
Show InChI InChI=1S/C7H12NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h8H,1-4H2,(H,9,10)(H,11,12)(H,13,14)
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n/an/an/an/a 4.30E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50034504
PNG
((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
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n/an/an/an/a 4.70E+4n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196914
PNG
(US9212196, Derivative 10)
Show SMILES Cc1cc(cc(C)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C15H22NO8P/c1-8-5-10(6-9(2)13(8)24-7-12(17)18)15(21)25(22,23)4-3-11(16)14(19)20/h5-6,11,15,21H,3-4,7,16H2,1-2H3,(H,17,18)(H,19,20)(H,22,23)/t11-,15?/m1/s1
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n/an/an/an/a 5.16E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196923
PNG
(US9212196, Derivative 19)
Show SMILES CCOc1cc(ccc1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C15H22NO9P/c1-2-24-12-7-9(3-4-11(12)25-8-13(17)18)15(21)26(22,23)6-5-10(16)14(19)20/h3-4,7,10,15,21H,2,5-6,8,16H2,1H3,(H,17,18)(H,19,20)(H,22,23)/t10-,15?/m1/s1
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US Patent
n/an/an/an/a 6.02E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196927
PNG
(US9212196, Derivative 23)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H18NO10P/c15-9(13(20)21)3-4-26(23,24)14(22)7-1-2-10(25-6-11(16)17)8(5-7)12(18)19/h1-2,5,9,14,22H,3-4,6,15H2,(H,16,17)(H,18,19)(H,20,21)(H,23,24)/t9-,14?/m1/s1
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n/an/an/an/a 6.50E+4n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 8.90E+4n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50138784
PNG
((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50138783
PNG
(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50138781
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196909
PNG
(US9212196, Derivative 5)
Show SMILES COc1cc(cc(c1OCC(O)=O)[N+]([O-])=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C14H19N2O11P/c1-26-10-5-7(4-9(16(22)23)12(10)27-6-11(17)18)14(21)28(24,25)3-2-8(15)13(19)20/h4-5,8,14,21H,2-3,6,15H2,1H3,(H,17,18)(H,19,20)(H,24,25)/t8-,14?/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50088290
PNG
(CHEMBL3427499)
Show SMILES NC1(CC1(F)CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H9FNO5P/c6-4(2-13(10,11)12)1-5(4,7)3(8)9/h1-2,7H2,(H,8,9)(H2,10,11,12)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Univ. Rouen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay


Bioorg Med Chem Lett 25: 2523-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.043
BindingDB Entry DOI: 10.7270/Q21Z464C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50314797
PNG
((3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CC(Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H13ClNO6P/c8-4(6(10)11)3-16(14,15)2-1-5(9)7(12)13/h4-5H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4?,5-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM82006
PNG
(D-AP4 | D-APB | US9212196, L-AP4)
Show SMILES N[C@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Univ. Rouen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay


Bioorg Med Chem Lett 25: 2523-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.043
BindingDB Entry DOI: 10.7270/Q21Z464C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196934
PNG
(US9212196, Derivative 30)
Show SMILES N[C@H](CCP(O)(=O)Cc1ccc(OCC(O)=O)cc1)C(O)=O
Show InChI InChI=1S/C13H18NO7P/c14-11(13(17)18)5-6-22(19,20)8-9-1-3-10(4-2-9)21-7-12(15)16/h1-4,11H,5-8,14H2,(H,15,16)(H,17,18)(H,19,20)/t11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196933
PNG
(US9212196, Derivative 29)
Show SMILES CC(Oc1ccc(cc1)C(O)P(O)(=O)CC[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H20NO8P/c1-8(12(16)17)23-10-4-2-9(3-5-10)14(20)24(21,22)7-6-11(15)13(18)19/h2-5,8,11,14,20H,6-7,15H2,1H3,(H,16,17)(H,18,19)(H,21,22)/t8?,11-,14?/m1/s1
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n/an/an/an/a 1.03E+5n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50159148
PNG
(CHEMBL3786667)
Show SMILES N[C@@H](C[C@@]1(C[C@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-4(6(12)13)2-8(7(14)15)1-3(8)5(10)11/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4-,8+/m0/s1
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n/an/an/an/a 1.20E+5n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay


J Med Chem 59: 914-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01333
BindingDB Entry DOI: 10.7270/Q2000408
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196908
PNG
(US9212196, Derivative 4)
Show SMILES COc1cc(cc(OC)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C15H22NO10P/c1-24-10-5-8(6-11(25-2)13(10)26-7-12(17)18)15(21)27(22,23)4-3-9(16)14(19)20/h5-6,9,15,21H,3-4,7,16H2,1-2H3,(H,17,18)(H,19,20)(H,22,23)/t9-,15?/m1/s1
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n/an/an/an/a 1.27E+5n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM17664
PNG
((2S)-2-amino-3-(phosphonooxy)propanoic acid | CHEM...)
Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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n/an/an/an/a 1.60E+5n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR7 in rat


J Med Chem 38: 1417-26 (1995)


Article DOI: 10.1021/jm00009a001
BindingDB Entry DOI: 10.7270/Q20R9Q1R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 1.60E+5n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR7 in rat


J Med Chem 38: 1417-26 (1995)


Article DOI: 10.1021/jm00009a001
BindingDB Entry DOI: 10.7270/Q20R9Q1R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 1.60E+5n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR7 in rat


J Med Chem 38: 1417-26 (1995)


Article DOI: 10.1021/jm00009a001
BindingDB Entry DOI: 10.7270/Q20R9Q1R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 1.75E+5n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50004881
PNG
((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Show SMILES NC(C(O)=O)c1ccc(cc1)P(O)(O)=O
Show InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
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n/an/an/an/a 1.85E+5n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


J Med Chem 47: 456-66 (2004)


Article DOI: 10.1021/jm030967o
BindingDB Entry DOI: 10.7270/Q2K936Z5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50220011
PNG
(CHEMBL243925 | L-(+)-2-amino-4-thiophosphonobutyri...)
Show SMILES N[C@@H](CCP(O)(O)=S)C(O)=O
Show InChI InChI=1S/C4H10NO4PS/c5-3(4(6)7)1-2-10(8,9)11/h3H,1-2,5H2,(H,6,7)(H2,8,9,11)/t3-/m0/s1
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n/an/an/an/a 1.97E+5n/an/an/an/a



Université Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR7 receptor expressed HEK293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 4656-64 (2007)


Article DOI: 10.1021/jm070400y
BindingDB Entry DOI: 10.7270/Q2XP74NQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM196938
PNG
(US9212196, Derivative 34)
Show SMILES COc1cc(CP(O)(=O)CC[C@@H](N)C(O)=O)cc(F)c1OCC(O)=O
Show InChI InChI=1S/C14H19FNO8P/c1-23-11-5-8(4-9(15)13(11)24-6-12(17)18)7-25(21,22)3-2-10(16)14(19)20/h4-5,10H,2-3,6-7,16H2,1H3,(H,17,18)(H,19,20)(H,21,22)/t10-/m1/s1
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US Patent
n/an/an/an/a 2.32E+5n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JJR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50293743
PNG
(CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...)
Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
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n/an/an/an/a 2.35E+5n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2P849B9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 2.49E+5n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


J Med Chem 53: 2797-813 (2010)


Article DOI: 10.1021/jm901523t
BindingDB Entry DOI: 10.7270/Q28W3F7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 2.52E+5n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 7


J Med Chem 40: 3700-5 (1997)


Article DOI: 10.1021/jm9703597
BindingDB Entry DOI: 10.7270/Q2W66MF9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM55081
PNG
(ML182 | VU0400195-3 | cid_46869947)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)C2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O
Show InChI InChI=1S/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,17-18H,9H2,(H,24,26)/t11-,12+,17-,18?/m1/s1
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n/an/an/an/a 2.71E+5n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2P849B9
More data for this
Ligand-Target Pair
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