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Compile Data Set for Download or QSAR

Found 199 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 8'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 8


(Mus musculus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 22n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse


J Med Chem 38: 1417-26 (1995)


Article DOI: 10.1021/jm00009a001
BindingDB Entry DOI: 10.7270/Q20R9Q1R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50138783
PNG
(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
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n/an/an/an/a 23n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50138783
PNG
(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
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n/an/an/an/a 44n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/s2
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n/an/an/an/a 290n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/s2
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n/an/an/an/a 290n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255396
PNG
(CHEMBL4067923)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(o1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O8P/c10-5(8(12)13)3-4-20(17,18)9(14)6-1-2-7(19-6)11(15)16/h1-2,5,9,14H,3-4,10H2,(H,12,13)(H,17,18)/t5-,9?/s2
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n/an/an/an/a 300n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50217031
PNG
((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m0/s1
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n/an/an/an/a 340n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255292
PNG
(CHEMBL4061423)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1csc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O7PS/c10-6(8(12)13)1-2-19(17,18)9(14)5-3-7(11(15)16)20-4-5/h3-4,6,9,14H,1-2,10H2,(H,12,13)(H,17,18)/t6-,9?/s2
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n/an/an/an/a 380n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Mus musculus)
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/s2
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n/an/an/an/a 400n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse


J Med Chem 38: 1417-26 (1995)


Article DOI: 10.1021/jm00009a001
BindingDB Entry DOI: 10.7270/Q20R9Q1R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255406
PNG
(CHEMBL4088782)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)5-6-21(19,20)11(16)7-1-3-8(4-2-7)13(17)18/h1-4,9,11,16H,5-6,12H2,(H,14,15)(H,19,20)/t9-,11?/s2
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n/an/an/an/a 490n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255292
PNG
(CHEMBL4061423)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1csc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O7PS/c10-6(8(12)13)1-2-19(17,18)9(14)5-3-7(11(15)16)20-4-5/h3-4,6,9,14H,1-2,10H2,(H,12,13)(H,17,18)/t6-,9?/s2
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University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255406
PNG
(CHEMBL4088782)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)5-6-21(19,20)11(16)7-1-3-8(4-2-7)13(17)18/h1-4,9,11,16H,5-6,12H2,(H,14,15)(H,19,20)/t9-,11?/s2
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n/an/an/an/a 530n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/s2
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n/an/an/an/a 560n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255390
PNG
(CHEMBL4091029)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(F)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14FN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/s2
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n/an/an/an/a 660n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255415
PNG
(CHEMBL4078629)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C12H14F3N2O7P/c13-12(14,15)7-5-6(1-2-9(7)17(21)22)11(20)25(23,24)4-3-8(16)10(18)19/h1-2,5,8,11,20H,3-4,16H2,(H,18,19)(H,23,24)/t8-,11?/s2
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n/an/an/an/a 980n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255336
PNG
(CHEMBL4064187)
Show SMILES N[C@@H](CCP(O)(=O)Cc1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O6P/c12-10(11(14)15)4-5-20(18,19)7-8-2-1-3-9(6-8)13(16)17/h1-3,6,10H,4-5,7,12H2,(H,14,15)(H,18,19)/t10-/s2
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255388
PNG
(CHEMBL4093492)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11?/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255389
PNG
(CHEMBL4072781)
Show SMILES N[C@@H](CCP(O)(=O)[C@H](O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11-/s2
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n/an/an/an/a 1.25E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255437
PNG
(CHEMBL4085750)
Show SMILES N[C@@H](CCP(O)(=O)[C@@H](O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11+/s2
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n/an/an/an/a 1.30E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255390
PNG
(CHEMBL4091029)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(F)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14FN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/s2
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n/an/an/an/a 1.30E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255388
PNG
(CHEMBL4093492)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11?/s2
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n/an/an/an/a 1.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255337
PNG
(CHEMBL4063142)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(c(c1)[N+]([O-])=O)C(F)(F)F)C(O)=O
Show InChI InChI=1/C12H14F3N2O7P/c13-12(14,15)7-2-1-6(5-9(7)17(21)22)11(20)25(23,24)4-3-8(16)10(18)19/h1-2,5,8,11,20H,3-4,16H2,(H,18,19)(H,23,24)/t8-,11?/s2
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n/an/an/an/a 1.54E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50434134
PNG
(CHEMBL2381641)
Show SMILES N[C@]1(CC(=C)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C9H11NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h4-6H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5-,6-,9-/s2
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n/an/an/an/a 1.59E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255403
PNG
(CHEMBL4101241)
Show SMILES Cc1ccc(cc1[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O7P/c1-7-2-3-8(6-10(7)14(18)19)12(17)22(20,21)5-4-9(13)11(15)16/h2-3,6,9,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t9-,12?/s2
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n/an/an/an/a 1.60E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50074749
PNG
((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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n/an/an/an/a 1.69E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cells


J Med Chem 50: 233-40 (2007)


Article DOI: 10.1021/jm060917u
BindingDB Entry DOI: 10.7270/Q21Z442N
More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50074749
PNG
((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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n/an/an/an/a 1.69E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR8


J Med Chem 42: 1027-40 (1999)


Article DOI: 10.1021/jm980616n
BindingDB Entry DOI: 10.7270/Q2WM1CKF
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255454
PNG
(CHEMBL4075877)
Show SMILES N[C@@H](CCP(O)(=O)C(N)c1csc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H14N3O6PS/c10-6(9(13)14)1-2-19(17,18)8(11)5-3-7(12(15)16)20-4-5/h3-4,6,8H,1-2,10-11H2,(H,13,14)(H,17,18)/t6-,8?/s2
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n/an/an/an/a 1.80E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255397
PNG
(CHEMBL4090179)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(s1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C9H13N2O7PS/c10-5(8(12)13)3-4-19(17,18)9(14)6-1-2-7(20-6)11(15)16/h1-2,5,9,14H,3-4,10H2,(H,12,13)(H,17,18)/t5-,9?/s2
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n/an/an/an/a 1.90E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50217030
PNG
((1S,2S)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5+/m1/s1
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n/an/an/an/a 2.15E+3n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255450
PNG
(CHEMBL4072409)
Show SMILES N[C@@H](CCP(O)(=O)C(N)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H16N3O6P/c12-9(11(15)16)4-5-21(19,20)10(13)7-2-1-3-8(6-7)14(17)18/h1-3,6,9-10H,4-5,12-13H2,(H,15,16)(H,19,20)/t9-,10?/s2
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n/an/an/an/a 2.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255346
PNG
(CHEMBL4085327)
Show SMILES COc1ccc(cc1[N+]([O-])=O)[C@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O8P/c1-22-10-3-2-7(6-9(10)14(18)19)12(17)23(20,21)5-4-8(13)11(15)16/h2-3,6,8,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t8-,12+/s2
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n/an/an/an/a 2.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255338
PNG
(CHEMBL4083240)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(Cl)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14ClN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/s2
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n/an/an/an/a 2.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255342
PNG
(CHEMBL4063720)
Show SMILES COc1ccc(cc1[N+]([O-])=O)[C@@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O8P/c1-22-10-3-2-7(6-9(10)14(18)19)12(17)23(20,21)5-4-8(13)11(15)16/h2-3,6,8,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t8-,12-/s2
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n/an/an/an/a 2.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255341
PNG
(CHEMBL4075070)
Show SMILES COc1ccc(cc1[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O8P/c1-22-10-3-2-7(6-9(10)14(18)19)12(17)23(20,21)5-4-8(13)11(15)16/h2-3,6,8,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t8-,12?/s2
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n/an/an/an/a 2.70E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255440
PNG
(CHEMBL4080400)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1c(cccc1[N+]([O-])=O)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14N3O9P/c12-6(10(15)16)4-5-24(22,23)11(17)9-7(13(18)19)2-1-3-8(9)14(20)21/h1-3,6,11,17H,4-5,12H2,(H,15,16)(H,22,23)/t6-,11?/s2
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n/an/an/an/a 2.90E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50202406
PNG
((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Show SMILES N[C@]1(CS(=O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C7H9NO5S/c8-7(6(11)12)1-14(13)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+,14?/s2
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n/an/an/an/a 3.07E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cells


J Med Chem 50: 233-40 (2007)


Article DOI: 10.1021/jm060917u
BindingDB Entry DOI: 10.7270/Q21Z442N
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255341
PNG
(CHEMBL4075070)
Show SMILES COc1ccc(cc1[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O8P/c1-22-10-3-2-7(6-9(10)14(18)19)12(17)23(20,21)5-4-8(13)11(15)16/h2-3,6,8,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t8-,12?/s2
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n/an/an/an/a 3.80E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255439
PNG
(CHEMBL4101745)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cc(ccc1O)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O8P/c12-8(10(15)16)3-4-22(20,21)11(17)7-5-6(13(18)19)1-2-9(7)14/h1-2,5,8,11,14,17H,3-4,12H2,(H,15,16)(H,20,21)/t8-,11?/s2
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n/an/an/an/a 4.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50434137
PNG
(CHEMBL2381649)
Show SMILES CC(=O)N[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1/C10H14N2O5/c1-3(13)12-4-2-10(11,9(16)17)7-5(4)6(7)8(14)15/h4-7H,2,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t4-,5-,6-,7-,10-/s2
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n/an/an/an/a 4.30E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


J Med Chem 56: 4442-55 (2013)


Article DOI: 10.1021/jm4000165
BindingDB Entry DOI: 10.7270/Q20003G4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255336
PNG
(CHEMBL4064187)
Show SMILES N[C@@H](CCP(O)(=O)Cc1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O6P/c12-10(11(14)15)4-5-20(18,19)7-8-2-1-3-9(6-8)13(16)17/h1-3,6,10H,4-5,7,12H2,(H,14,15)(H,18,19)/t10-/s2
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n/an/an/an/a 4.40E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255394
PNG
(CHEMBL4069700)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14N3O10P/c12-7(10(16)17)1-2-25(23,24)11(18)6-3-5(13(19)20)4-8(9(6)15)14(21)22/h3-4,7,11,15,18H,1-2,12H2,(H,16,17)(H,23,24)/t7-,11?/s2
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n/an/an/an/a 4.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255291
PNG
(CHEMBL4060017)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14N3O9P/c12-8(10(15)16)3-4-24(22,23)11(17)7-2-1-6(13(18)19)5-9(7)14(20)21/h1-2,5,8,11,17H,3-4,12H2,(H,15,16)(H,22,23)/t8-,11?/s2
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n/an/an/an/a 4.60E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255338
PNG
(CHEMBL4083240)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(Cl)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H14ClN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/s2
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n/an/an/an/a 4.90E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50060137
PNG
((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Show SMILES N[C@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8-
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n/an/an/an/a 5.10E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255398
PNG
(CHEMBL4077371)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(o1)C(F)(F)F)C(O)=O
Show InChI InChI=1/C10H13F3NO6P/c11-10(12,13)7-2-1-6(20-7)9(17)21(18,19)4-3-5(14)8(15)16/h1-2,5,9,17H,3-4,14H2,(H,15,16)(H,18,19)/t5-,9?/s2
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n/an/an/an/a 5.20E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255334
PNG
(CHEMBL4094241)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cc(O)c(O)c(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1/C11H15N2O9P/c12-6(10(16)17)1-2-23(21,22)11(18)5-3-7(13(19)20)9(15)8(14)4-5/h3-4,6,11,14-15,18H,1-2,12H2,(H,16,17)(H,21,22)/t6-,11?/s2
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n/an/an/an/a 5.40E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255403
PNG
(CHEMBL4101241)
Show SMILES Cc1ccc(cc1[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C12H17N2O7P/c1-7-2-3-8(6-10(7)14(18)19)12(17)22(20,21)5-4-9(13)11(15)16/h2-3,6,9,12,17H,4-5,13H2,1H3,(H,15,16)(H,20,21)/t9-,12?/s2
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n/an/an/an/a 5.60E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/s2
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n/an/an/an/a 6.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))
BDBM50255368
PNG
(CHEMBL4066711)
Show SMILES CCOc1cc(cc(c1O)[N+]([O-])=O)[C@H](O)P(O)(=O)CC[C@H](N)C(O)=O
Show InChI InChI=1/C13H19N2O9P/c1-2-24-10-6-7(5-9(11(10)16)15(20)21)13(19)25(22,23)4-3-8(14)12(17)18/h5-6,8,13,16,19H,2-4,14H2,1H3,(H,17,18)(H,22,23)/t8-,13+/s2
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n/an/an/an/a 6.50E+3n/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...


J Med Chem 61: 1969-1989 (2018)

More data for this
Ligand-Target Pair
GRM8


(Homo sapiens (Human))
BDBM50089516
PNG
((1R,2S)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Show SMILES N[C@@]1(C[C@@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m1/s1
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Article
PubMed
n/an/an/an/a 6.51E+3n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
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