BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 29 hits Enz. Inhib. hit(s) with Target = 'Methionine aminopeptidase Type 2 (MetAP2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36590
PNG
(FOS-72)
Show SMILES CO[C@H]1C([C@]2(C)OC2CC=C(C)C)[C@@]2(CO2)CCC1=O
Show InChI InChI=1S/C16H24O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,12-14H,6-9H2,1-4H3/t12?,13-,14?,15-,16+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0130n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36589
PNG
(Ovalicin)
Show SMILES CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12?,13-,14-,15+,16+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0180n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36588
PNG
(AGM-1470)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0370n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36592
PNG
(FOS-70)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO5/c1-13(2)7-8-15-19(3,26-15)18-17(23-4)14(9-10-20(18)12-24-20)25-16(22)6-5-11-21/h7,14-15,17-18H,5-6,8-12H2,1-4H3/t14-,15?,17-,18?,19-,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.120n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36597
PNG
(FOS-69)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO6/c1-13(2)7-8-15-18(3,27-15)20(23)17(24-4)14(9-10-19(20)12-25-19)26-16(22)6-5-11-21/h7,14-15,17,23H,5-6,8-12H2,1-4H3/t14-,15?,17-,18-,19+,20+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.310n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36595
PNG
(FOS-68)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO7/c1-11(2)5-6-13-17(3,28-13)19(24)15(25-4)12(7-8-18(19)10-26-18)27-16(23)21-14(22)9-20/h5,12-13,15,24H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.460n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36596
PNG
(FOS-34)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12?,13-,14-,15+,16+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.20n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36591
PNG
(FOS-37)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,11-14,17H,6-9H2,1-4H3/t11-,12?,13-,14?,15-,16+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.5n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36598
PNG
(FOS-67)
Show SMILES CO[C@@H]1[C@@H](CC[C@](O)(SC)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H30ClNO7S/c1-11(2)6-7-13-17(3,28-13)19(25)15(26-4)12(8-9-18(19,24)29-5)27-16(23)21-14(22)10-20/h6,12-13,15,24-25H,7-10H2,1-5H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 40n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36599
PNG
(FOS-201)
Show SMILES CO[C@@H]1[C@H](O)CC[C@](O)(SC)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H28O5S/c1-10(2)6-7-12-14(3,21-12)16(19)13(20-4)11(17)8-9-15(16,18)22-5/h6,11-13,17-19H,7-9H2,1-5H3/t11-,12?,13-,14-,15+,16+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 56n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36593
PNG
(FOS-64)
Show SMILES CO[C@@H]1[C@@H](CC[C@](O)(SC)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H30ClNO6S/c1-11(2)6-7-13-18(3,27-13)16-15(25-4)12(8-9-19(16,24)28-5)26-17(23)21-14(22)10-20/h6,12-13,15-16,24H,7-10H2,1-5H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 110n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM36594
PNG
(FOS-202)
Show SMILES CO[C@@H]1[C@H](O)CC[C@](O)(SC)C1[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H28O4S/c1-10(2)6-7-12-15(3,20-12)14-13(19-4)11(17)8-9-16(14,18)21-5/h6,11-14,17-18H,7-9H2,1-5H3/t11-,12?,13-,14?,15-,16+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.80E+3n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468963
PNG
(1-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tet...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1cc(cn1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2)C1=O
Show InChI InChI=1S/C26H25Cl2F2N5O4/c27-15-5-14(6-16(28)7-15)10-32-24(36)26(38)3-4-34(25(26)37)19-11-33-35(12-19)18-9-22(31)23(39-13-18)20-8-17(29)1-2-21(20)30/h1-2,5-8,11-12,18,22-23,38H,3-4,9-10,13,31H2,(H,32,36)/t18-,22+,23-,26?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 123n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468964
PNG
(1-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tet...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1cc(cn1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O
Show InChI InChI=1S/C26H24Cl2F3N5O4/c27-14-5-13(22(31)19(28)6-14)9-33-24(37)26(39)3-4-35(25(26)38)17-10-34-36(11-17)16-8-21(32)23(40-12-16)18-7-15(29)1-2-20(18)30/h1-2,5-7,10-11,16,21,23,39H,3-4,8-9,12,32H2,(H,33,37)/t16-,21+,23-,26?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36.8n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468972
PNG
((3S)-1-[2-[(3R,5S,6R)-5-Amino-6-(2,5-difluoropheny...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ncc(n1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C25H24ClF3N6O4/c26-14-5-13(6-16(28)7-14)10-31-23(36)25(38)3-4-34(24(25)37)21-11-32-35(33-21)17-9-20(30)22(39-12-17)18-8-15(27)1-2-19(18)29/h1-2,5-8,11,17,20,22,38H,3-4,9-10,12,30H2,(H,31,36)/t17-,20+,22-,25+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468973
PNG
(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ncc(n1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O
Show InChI InChI=1S/C25H24F4N6O4/c26-14-4-5-17(27)16(8-14)22-19(30)9-15(12-39-22)35-32-11-20(33-35)34-7-6-25(38,24(34)37)23(36)31-10-13-2-1-3-18(28)21(13)29/h1-5,8,11,15,19,22,38H,6-7,9-10,12,30H2,(H,31,36)/t15-,19+,22-,25?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 154n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468961
PNG
((3S)-1-[6-[4-[(3S,5S,6R)-5-Amino-6-(2,5-difluoroph...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1CCN(CC1)c1ccc(cn1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C32H34ClF3N6O4/c33-20-11-19(12-22(35)13-20)16-39-30(43)32(45)5-6-42(31(32)44)23-2-4-28(38-17-23)41-9-7-40(8-10-41)24-15-27(37)29(46-18-24)25-14-21(34)1-3-26(25)36/h1-4,11-14,17,24,27,29,45H,5-10,15-16,18,37H2,(H,39,43)/t24-,27+,29-,32+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 80.2n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468960
PNG
(1-[2-[4-[(3R,5S,6R)-5- Amino-6-(2,5- difluoropheny...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1CCN(CC1)c1ncc(cn1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2F)C1=O
Show InChI InChI=1S/C31H32F5N7O4/c32-18-1-2-23(34)22(10-18)27-25(37)12-20(16-47-27)41-5-7-42(8-6-41)30-39-14-21(15-40-30)43-4-3-31(46,29(43)45)28(44)38-13-17-9-19(33)11-24(35)26(17)36/h1-2,9-11,14-15,20,25,27,46H,3-8,12-13,16,37H2,(H,38,44)/t20-,25+,27-,31?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 111n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468959
PNG
(1-[2-[4-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1CCN(CC1)c1ncc(cn1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O
Show InChI InChI=1S/C31H33F4N7O4/c32-19-4-5-23(33)22(12-19)27-25(36)13-20(17-46-27)40-8-10-41(11-9-40)30-38-15-21(16-39-30)42-7-6-31(45,29(42)44)28(43)37-14-18-2-1-3-24(34)26(18)35/h1-5,12,15-16,20,25,27,45H,6-11,13-14,17,36H2,(H,37,43)/t20-,25+,27-,31?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 103n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468958
PNG
(1-[2-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O
Show InChI InChI=1S/C31H30F4N4O4/c32-20-5-7-24(33)23(11-20)28-26(36)12-22(16-43-28)38-14-18-4-6-21(10-19(18)15-38)39-9-8-31(42,30(39)41)29(40)37-13-17-2-1-3-25(34)27(17)35/h1-7,10-11,22,26,28,42H,8-9,12-16,36H2,(H,37,40)/t22-,26+,28-,31?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 33.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468957
PNG
(1-[2-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tet...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2F)C1=O
Show InChI InChI=1S/C31H29F5N4O4/c32-19-2-4-24(34)23(9-19)28-26(37)11-22(15-44-28)39-13-16-1-3-21(8-18(16)14-39)40-6-5-31(43,30(40)42)29(41)38-12-17-7-20(33)10-25(35)27(17)36/h1-4,7-10,22,26,28,43H,5-6,11-15,37H2,(H,38,41)/t22-,26+,28-,31?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21.9n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468981
PNG
((3S)-1-[2-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluoroph...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1CCC(=CC1)c1ncc(cn1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C32H32ClF3N6O4/c33-20-9-18(10-22(35)11-20)14-40-30(43)32(45)5-8-42(31(32)44)24-15-38-29(39-16-24)19-3-6-41(7-4-19)23-13-27(37)28(46-17-23)25-12-21(34)1-2-26(25)36/h1-3,9-12,15-16,23,27-28,45H,4-8,13-14,17,37H2,(H,40,43)/t23-,27+,28-,32+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 283n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468980
PNG
(1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cccc(F)c2)C1=O
Show InChI InChI=1S/C26H26F3N5O4/c27-16-3-1-2-15(10-16)13-31-24(35)26(37)7-9-33(25(26)36)22-6-8-34(32-22)18-12-21(30)23(38-14-18)19-11-17(28)4-5-20(19)29/h1-6,8,10-11,18,21,23,37H,7,9,12-14,30H2,(H,31,35)/t18-,21+,23-,26?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60.3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468979
PNG
(1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2)C1=O
Show InChI InChI=1S/C26H25F4N5O4/c27-15-1-2-20(30)19(10-15)23-21(31)11-18(13-39-23)35-5-3-22(33-35)34-6-4-26(38,25(34)37)24(36)32-12-14-7-16(28)9-17(29)8-14/h1-3,5,7-10,18,21,23,38H,4,6,11-13,31H2,(H,32,36)/t18-,21+,23-,26?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30.5n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468978
PNG
(1-[1-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2F)C1=O
Show InChI InChI=1S/C26H24F5N5O4/c27-14-1-2-18(29)17(8-14)23-20(32)10-16(12-40-23)36-5-3-21(34-36)35-6-4-26(39,25(35)38)24(37)33-11-13-7-15(28)9-19(30)22(13)31/h1-3,5,7-9,16,20,23,39H,4,6,10-12,32H2,(H,33,37)/t16-,20+,23-,26?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29.2n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468974
PNG
(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ncc(n1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2F)C1=O
Show InChI InChI=1S/C25H23F5N6O4/c26-13-1-2-17(28)16(6-13)22-19(31)8-15(11-40-22)36-33-10-20(34-36)35-4-3-25(39,24(35)38)23(37)32-9-12-5-14(27)7-18(29)21(12)30/h1-2,5-7,10,15,19,22,39H,3-4,8-9,11,31H2,(H,32,37)/t15-,19+,22-,25?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 94.7n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468976
PNG
((3S)-1-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluoropheny...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
Show InChI InChI=1S/C26H25ClF3N5O4/c27-15-7-14(8-17(29)9-15)12-32-24(36)26(38)4-6-34(25(26)37)22-3-5-35(33-22)18-11-21(31)23(39-13-18)19-10-16(28)1-2-20(19)30/h1-3,5,7-10,18,21,23,38H,4,6,11-13,31H2,(H,32,36)/t18-,21+,23-,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.1n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468975
PNG
(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ncc(n1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O
Show InChI InChI=1S/C25H23Cl2F3N6O4/c26-13-5-12(21(30)17(27)6-13)9-32-23(37)25(39)3-4-35(24(25)38)20-10-33-36(34-20)15-8-19(31)22(40-11-15)16-7-14(28)1-2-18(16)29/h1-2,5-7,10,15,19,22,39H,3-4,8-9,11,31H2,(H,32,37)/t15-,19+,22-,25?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.8n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Mus musculus (Mouse))
BDBM468977
PNG
(1-[2-[(3R,5S,6R)-5-Aamino- 6-(2,5- difluorophenyl)...)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O
Show InChI InChI=1S/C26H24Cl2F3N5O4/c27-14-7-13(22(31)18(28)8-14)11-33-24(37)26(39)4-6-35(25(26)38)21-3-5-36(34-21)16-10-20(32)23(40-12-16)17-9-15(29)1-2-19(17)30/h1-3,5,7-9,16,20,23,39H,4,6,10-12,32H2,(H,33,37)/t16-,20+,23-,26?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...


US Patent US10807971 (2020)

More data for this
Ligand-Target Pair