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Compile Data Set for Download or QSAR

Found 15708 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420692
PNG
(CHEMBL2087076)
Show SMILES OCCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C16H14FIN4O3/c17-12-7-9(18)1-3-14(12)20-15-10(16(24)22-25-6-5-23)2-4-13-11(15)8-19-21-13/h1-4,7-8,20,23H,5-6H2,(H,19,21)(H,22,24)
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n/an/an/an/a 0.200n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420696
PNG
(CHEMBL2087080)
Show SMILES OC[C@@H](O)CONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H16FIN4O4/c18-13-5-9(19)1-3-15(13)21-16-11(2-4-14-12(16)6-20-22-14)17(26)23-27-8-10(25)7-24/h1-6,10,21,24-25H,7-8H2,(H,20,22)(H,23,26)/t10-/m1/s1
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n/an/an/an/a 0.400n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420692
PNG
(CHEMBL2087076)
Show SMILES OCCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C16H14FIN4O3/c17-12-7-9(18)1-3-14(12)20-15-10(16(24)22-25-6-5-23)2-4-13-11(15)8-19-21-13/h1-4,7-8,20,23H,5-6H2,(H,19,21)(H,22,24)
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n/an/an/an/a 0.400n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420701
PNG
(CHEMBL2087461)
Show SMILES OCCONC(=O)c1ccc2cnsc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C16H13FIN3O3S/c17-12-7-10(18)2-4-13(12)20-14-11(16(23)21-24-6-5-22)3-1-9-8-19-25-15(9)14/h1-4,7-8,20,22H,5-6H2,(H,21,23)
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n/an/an/an/a 0.600n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420701
PNG
(CHEMBL2087461)
Show SMILES OCCONC(=O)c1ccc2cnsc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C16H13FIN3O3S/c17-12-7-10(18)2-4-13(12)20-14-11(16(23)21-24-6-5-22)3-1-9-8-19-25-15(9)14/h1-4,7-8,20,22H,5-6H2,(H,21,23)
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n/an/an/an/a 0.900n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420702
PNG
(CHEMBL2087462)
Show SMILES OC[C@@H](O)CONC(=O)c1ccc2cnsc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H15FIN3O4S/c18-13-5-10(19)2-4-14(13)21-15-12(3-1-9-6-20-27-16(9)15)17(25)22-26-8-11(24)7-23/h1-6,11,21,23-24H,7-8H2,(H,22,25)/t11-/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420702
PNG
(CHEMBL2087462)
Show SMILES OC[C@@H](O)CONC(=O)c1ccc2cnsc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H15FIN3O4S/c18-13-5-10(19)2-4-14(13)21-15-12(3-1-9-6-20-27-16(9)15)17(25)22-26-8-11(24)7-23/h1-6,11,21,23-24H,7-8H2,(H,22,25)/t11-/m1/s1
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n/an/an/an/a 1.10n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420698
PNG
(CHEMBL2087082)
Show SMILES CCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C16H14FIN4O2/c1-2-24-22-16(23)10-4-6-13-11(8-19-21-13)15(10)20-14-5-3-9(18)7-12(14)17/h3-8,20H,2H2,1H3,(H,19,21)(H,22,23)
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n/an/an/an/a 1.30n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420697
PNG
(CHEMBL2087081)
Show SMILES Fc1cc(I)ccc1Nc1c(ccc2[nH]ncc12)C(=O)NOCC1CC1
Show InChI InChI=1S/C18H16FIN4O2/c19-14-7-11(20)3-5-16(14)22-17-12(4-6-15-13(17)8-21-23-15)18(25)24-26-9-10-1-2-10/h3-8,10,22H,1-2,9H2,(H,21,23)(H,24,25)
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n/an/an/an/a 1.5n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420697
PNG
(CHEMBL2087081)
Show SMILES Fc1cc(I)ccc1Nc1c(ccc2[nH]ncc12)C(=O)NOCC1CC1
Show InChI InChI=1S/C18H16FIN4O2/c19-14-7-11(20)3-5-16(14)22-17-12(4-6-15-13(17)8-21-23-15)18(25)24-26-9-10-1-2-10/h3-8,10,22H,1-2,9H2,(H,21,23)(H,24,25)
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n/an/an/an/a 1.5n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20652
PNG
(N-[(2S)-butan-2-yl]-4-{[5-(methoxycarbamoyl)-2-met...)
Show SMILES CC[C@H](C)NC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C
Show InChI InChI=1S/C21H26N6O3/c1-6-13(3)24-21(29)16-10-27-18(14(16)4)19(22-11-23-27)25-17-9-15(8-7-12(17)2)20(28)26-30-5/h7-11,13H,6H2,1-5H3,(H,24,29)(H,26,28)(H,22,23,25)/t13-/m0/s1
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n/an/a 3n/a<2n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20656
PNG
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCc4ccccn4)c(C)c23)c1
Show InChI InChI=1S/C23H23N7O3/c1-14-7-8-16(22(31)29-33-3)10-19(14)28-21-20-15(2)18(12-30(20)27-13-26-21)23(32)25-11-17-6-4-5-9-24-17/h4-10,12-13H,11H2,1-3H3,(H,25,32)(H,29,31)(H,26,27,28)
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n/an/a 1.20n/a 2.40n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420698
PNG
(CHEMBL2087082)
Show SMILES CCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C16H14FIN4O2/c1-2-24-22-16(23)10-4-6-13-11(8-19-21-13)15(10)20-14-5-3-9(18)7-12(14)17/h3-8,20H,2H2,1H3,(H,19,21)(H,22,23)
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n/an/an/an/a 2.40n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420695
PNG
(CHEMBL2087079)
Show SMILES OCCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(Br)cc1F
Show InChI InChI=1S/C16H14BrFN4O3/c17-9-1-3-14(12(18)7-9)20-15-10(16(24)22-25-6-5-23)2-4-13-11(15)8-19-21-13/h1-4,7-8,20,23H,5-6H2,(H,19,21)(H,22,24)
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n/an/an/an/a 3.40n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420696
PNG
(CHEMBL2087080)
Show SMILES OC[C@@H](O)CONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H16FIN4O4/c18-13-5-9(19)1-3-15(13)21-16-11(2-4-14-12(16)6-20-22-14)17(26)23-27-8-10(25)7-24/h1-6,10,21,24-25H,7-8H2,(H,20,22)(H,23,26)/t10-/m1/s1
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n/an/an/an/a 3.70n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420694
PNG
(CHEMBL2087078)
Show SMILES C[C@H](O)CONC(=O)c1oc2c(F)cncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H14F2IN3O4/c1-8(24)7-26-23-17(25)16-14(10-5-21-6-12(19)15(10)27-16)22-13-3-2-9(20)4-11(13)18/h2-6,8,22,24H,7H2,1H3,(H,23,25)/t8-/m0/s1
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n/an/an/an/a 4n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420693
PNG
(CHEMBL2087077)
Show SMILES OC[C@@H](O)CONC(=O)c1oc2ccncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H15FIN3O5/c18-12-5-9(19)1-2-13(12)21-15-11-6-20-4-3-14(11)27-16(15)17(25)22-26-8-10(24)7-23/h1-6,10,21,23-24H,7-8H2,(H,22,25)/t10-/m1/s1
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n/an/an/an/a 6.30n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420695
PNG
(CHEMBL2087079)
Show SMILES OCCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(Br)cc1F
Show InChI InChI=1S/C16H14BrFN4O3/c17-9-1-3-14(12(18)7-9)20-15-10(16(24)22-25-6-5-23)2-4-13-11(15)8-19-21-13/h1-4,7-8,20,23H,5-6H2,(H,19,21)(H,22,24)
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n/an/an/an/a 6.40n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM36476
PNG
((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Show SMILES CNC(=O)[C@H](Cc1ccc2OC(C)(C)OCc2c1)Nc1nc(nc(=O)[nH]1)-n1cnc2ccc(cc12)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C34H34N8O5/c1-34(2)46-18-23-15-20(10-13-28(23)47-34)16-25(29(43)35-3)37-31-38-32(40-33(45)39-31)42-19-36-24-12-11-22(17-27(24)42)30(44)41-14-6-8-21-7-4-5-9-26(21)41/h4-5,7,9-13,15,17,19,25H,6,8,14,16,18H2,1-3H3,(H,35,43)(H2,37,38,39,40,45)/t25-/m0/s1
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n/an/an/an/a<7n/an/a9.516



Praecis Pharmaceuticals



Assay Description
Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...


Nat Chem Biol 5: 647-54 (2009)


Article DOI: 10.1038/nchembio.211
BindingDB Entry DOI: 10.7270/Q2MP51NX
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420694
PNG
(CHEMBL2087078)
Show SMILES C[C@H](O)CONC(=O)c1oc2c(F)cncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H14F2IN3O4/c1-8(24)7-26-23-17(25)16-14(10-5-21-6-12(19)15(10)27-16)22-13-3-2-9(20)4-11(13)18/h2-6,8,22,24H,7H2,1H3,(H,23,25)/t8-/m0/s1
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n/an/an/an/a 7.20n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM36474
PNG
((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Show SMILES CCOc1nc(N[C@@H](Cc2ccc3OC(C)(C)OCc3c2)C(=O)NC)nc(n1)-n1cnc2ccc(cc12)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C36H38N8O5/c1-5-47-35-41-33(39-27(31(45)37-4)18-22-12-15-30-25(17-22)20-48-36(2,3)49-30)40-34(42-35)44-21-38-26-14-13-24(19-29(26)44)32(46)43-16-8-10-23-9-6-7-11-28(23)43/h6-7,9,11-15,17,19,21,27H,5,8,10,16,18,20H2,1-4H3,(H,37,45)(H,39,40,41,42)/t27-/m0/s1
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n/an/an/an/a<8n/an/a9.516



Praecis Pharmaceuticals



Assay Description
Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...


Nat Chem Biol 5: 647-54 (2009)


Article DOI: 10.1038/nchembio.211
BindingDB Entry DOI: 10.7270/Q2MP51NX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20655
PNG
(N-benzyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCc4ccccc4)c(C)c23)c1
Show InChI InChI=1S/C24H24N6O3/c1-15-9-10-18(23(31)29-33-3)11-20(15)28-22-21-16(2)19(13-30(21)27-14-26-22)24(32)25-12-17-7-5-4-6-8-17/h4-11,13-14H,12H2,1-3H3,(H,25,32)(H,29,31)(H,26,27,28)
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n/an/a 0.400n/a 9.60n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194056
PNG
(5-3-chloro-4-2,3-dichlorophenoxy)phenylamino)-3-hy...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3cccc(Cl)c3Cl)c(Cl)c2)s[nH]c1=O
Show InChI InChI=1S/C19H17Cl3N4O3S/c1-9(8-27)24-17(23)15-18(28)26-30-19(15)25-10-5-6-13(12(21)7-10)29-14-4-2-3-11(20)16(14)22/h2-7,9,25,27H,8H2,1H3,(H2,23,24)(H,26,28)
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n/an/an/an/a>10n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194036
PNG
(5-3-chloro-4-2-chloro-5-fluorophenoxy)phenylamino)...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3cc(F)ccc3Cl)c(Cl)c2)s[nH]c1=O
Show InChI InChI=1S/C19H17Cl2FN4O3S/c1-9(8-27)24-17(23)16-18(28)26-30-19(16)25-11-3-5-14(13(21)7-11)29-15-6-10(22)2-4-12(15)20/h2-7,9,25,27H,8H2,1H3,(H2,23,24)(H,26,28)
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n/an/an/an/a>10n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibition of MEK-1 activity


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20657
PNG
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)c4ccccc4)c(C)c23)c1
Show InChI InChI=1S/C25H26N6O3/c1-15-10-11-19(24(32)30-34-4)12-21(15)29-23-22-16(2)20(13-31(22)27-14-26-23)25(33)28-17(3)18-8-6-5-7-9-18/h5-14,17H,1-4H3,(H,28,33)(H,30,32)(H,26,27,29)/t17-/m0/s1
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n/an/a 2.20n/a 10n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229700
PNG
(CHEMBL4085167)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-9-6-10(15)7-11(16)12(9)17/h6-7H,5,8H2,1-4H3
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n/an/an/an/a 12n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM36372
PNG
((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O
Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1
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n/an/an/an/a 18n/an/a7.330



Tufts University



Assay Description
In vitro kinase assay using RIP1


Nat Chem Biol 4: 313-21 (2008)


Article DOI: 10.1038/nchembio.83
BindingDB Entry DOI: 10.7270/Q21V5C91
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194026
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-N-3,4-dihydro...)
Show SMILES NC(=NCCC(O)CO)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C20H20Cl2N4O4S/c21-11-1-6-15(22)16(9-11)30-14-4-2-12(3-5-14)25-20-17(19(29)26-31-20)18(23)24-8-7-13(28)10-27/h1-6,9,13,25,27-28H,7-8,10H2,(H2,23,24)(H,26,29)
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n/an/an/an/a 22n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20665
PNG
(ethyl N-(4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Show SMILES CCOC(=O)Nc1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C
Show InChI InChI=1S/C19H22N6O4/c1-5-29-19(27)23-15-9-25-16(12(15)3)17(20-10-21-25)22-14-8-13(7-6-11(14)2)18(26)24-28-4/h6-10H,5H2,1-4H3,(H,23,27)(H,24,26)(H,20,21,22)
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n/an/a 1.5n/a 26n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229025
PNG
(CHEMBL4092421)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccccc1
Show InChI InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
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n/an/an/an/a 28n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194067
PNG
(5-4-3-fluoro-5-trifluoromethyl)phenoxy)phenylamino...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3cc(F)cc(c3)C(F)(F)F)cc2)s[nH]c1=O
Show InChI InChI=1S/C20H18F4N4O3S/c1-10(9-29)26-17(25)16-18(30)28-32-19(16)27-13-2-4-14(5-3-13)31-15-7-11(20(22,23)24)6-12(21)8-15/h2-8,10,27,29H,9H2,1H3,(H2,25,26)(H,28,30)
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n/an/an/an/a 30n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibition of MEK-1 activity


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20650
PNG
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Show SMILES CCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C
Show InChI InChI=1S/C20H24N6O3/c1-5-8-21-20(28)15-10-26-17(13(15)3)18(22-11-23-26)24-16-9-14(7-6-12(16)2)19(27)25-29-4/h6-7,9-11H,5,8H2,1-4H3,(H,21,28)(H,25,27)(H,22,23,24)
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n/an/a 0.900n/a 30n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50420693
PNG
(CHEMBL2087077)
Show SMILES OC[C@@H](O)CONC(=O)c1oc2ccncc2c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C17H15FIN3O5/c18-12-5-9(19)1-2-13(12)21-15-11-6-20-4-3-14(11)27-16(15)17(25)22-26-8-10(24)7-23/h1-6,10,21,23-24H,7-8H2,(H,22,25)/t10-/m1/s1
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n/an/an/an/a 34n/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting method


J Med Chem 55: 4594-604 (2012)


Article DOI: 10.1021/jm2017094
BindingDB Entry DOI: 10.7270/Q2BP043M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194034
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Show SMILES NC(=NCCN1CCOCC1)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C22H23Cl2N5O3S/c23-14-1-6-17(24)18(13-14)32-16-4-2-15(3-5-16)27-22-19(21(30)28-33-22)20(25)26-7-8-29-9-11-31-12-10-29/h1-6,13,27H,7-12H2,(H2,25,26)(H,28,30)
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n/an/an/an/a 35n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229585
PNG
(CHEMBL4076443)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)ccc1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-8-11(15)6-7-12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 36n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194027
PNG
(5-3-chloro-4-2-chloro-4-fluorophenoxy)phenylamino)...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3ccc(F)cc3Cl)c(Cl)c2)s[nH]c1=O
Show InChI InChI=1S/C19H17Cl2FN4O3S/c1-9(8-27)24-17(23)16-18(28)26-30-19(16)25-11-3-5-15(13(21)7-11)29-14-4-2-10(22)6-12(14)20/h2-7,9,25,27H,8H2,1H3,(H2,23,24)(H,26,28)
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n/an/an/an/a 37n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20645
PNG
(ethyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amin...)
Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C
Show InChI InChI=1S/C19H21N5O4/c1-5-28-19(26)14-9-24-16(12(14)3)17(20-10-21-24)22-15-8-13(7-6-11(15)2)18(25)23-27-4/h6-10H,5H2,1-4H3,(H,23,25)(H,20,21,22)
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n/an/a 0.900n/a 37n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20651
PNG
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NC(C)C)c(C)c23)c1
Show InChI InChI=1S/C20H24N6O3/c1-11(2)23-20(28)15-9-26-17(13(15)4)18(21-10-22-26)24-16-8-14(7-6-12(16)3)19(27)25-29-5/h6-11H,1-5H3,(H,23,28)(H,25,27)(H,21,22,24)
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n/an/a 10n/a 41n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194024
PNG
(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3ccccc3)cc2)s[nH]c1=O
Show InChI InChI=1S/C19H20N4O3S/c1-12(11-24)21-17(20)16-18(25)23-27-19(16)22-13-7-9-15(10-8-13)26-14-5-3-2-4-6-14/h2-10,12,22,24H,11H2,1H3,(H2,20,21)(H,23,25)
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n/an/an/an/a 42n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194053
PNG
(5-4-2,3-difluorophenoxy)phenylamino)-3-hydroxy-N-1...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3cccc(F)c3F)cc2)s[nH]c1=O
Show InChI InChI=1S/C19H18F2N4O3S/c1-10(9-26)23-17(22)15-18(27)25-29-19(15)24-11-5-7-12(8-6-11)28-14-4-2-3-13(20)16(14)21/h2-8,10,24,26H,9H2,1H3,(H2,22,23)(H,25,27)
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n/an/an/an/a 42n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibition of MEK-1 activity


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20671
PNG
(4-{[5-(2-methoxyacetamido)-2-methylphenyl]amino}-5...)
Show SMILES CCCNC(=O)c1cn2ncnc(Nc3cc(NC(=O)COC)ccc3C)c2c1C
Show InChI InChI=1S/C21H26N6O3/c1-5-8-22-21(29)16-10-27-19(14(16)3)20(23-12-24-27)26-17-9-15(7-6-13(17)2)25-18(28)11-30-4/h6-7,9-10,12H,5,8,11H2,1-4H3,(H,22,29)(H,25,28)(H,23,24,26)
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n/an/a 20n/a 43n/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20654
PNG
(N-cyclopentyl-4-{[5-(methoxycarbamoyl)-2-methylphe...)
Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NC4CCCC4)c(C)c23)c1
Show InChI InChI=1S/C22H26N6O3/c1-13-8-9-15(21(29)27-31-3)10-18(13)26-20-19-14(2)17(11-28(19)24-12-23-20)22(30)25-16-6-4-5-7-16/h8-12,16H,4-7H2,1-3H3,(H,25,30)(H,27,29)(H,23,24,26)
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n/an/a 8n/a 43n/an/a7.522



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194025
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Show SMILES NC(=NCCN1CCNCC1)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C22H24Cl2N6O2S/c23-14-1-6-17(24)18(13-14)32-16-4-2-15(3-5-16)28-22-19(21(31)29-33-22)20(25)27-9-12-30-10-7-26-8-11-30/h1-6,13,26,28H,7-12H2,(H2,25,27)(H,29,31)
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n/an/an/an/a 43n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50196392
PNG
(3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenyl...)
Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Nc3ccccc3)cc2)s[nH]c1=O
Show InChI InChI=1S/C19H21N5O2S/c1-12(11-25)21-17(20)16-18(26)24-27-19(16)23-15-9-7-14(8-10-15)22-13-5-3-2-4-6-13/h2-10,12,22-23,25H,11H2,1H3,(H2,20,21)(H,24,26)
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n/an/an/an/a 45n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibition of MEK-1 activity


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194028
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Show SMILES NC(=NCCO)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C18H16Cl2N4O3S/c19-10-1-6-13(20)14(9-10)27-12-4-2-11(3-5-12)23-18-15(17(26)24-28-18)16(21)22-7-8-25/h1-6,9,23,25H,7-8H2,(H2,21,22)(H,24,26)
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n/an/an/an/a 47n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194051
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-m...)
Show SMILES NC(=NN1CCOCC1)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C20H19Cl2N5O3S/c21-12-1-6-15(22)16(11-12)30-14-4-2-13(3-5-14)24-20-17(19(28)26-31-20)18(23)25-27-7-9-29-10-8-27/h1-6,11,24H,7-10H2,(H2,23,25)(H,26,28)
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n/an/an/an/a 47n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibitory activity against MEK-1


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM20675
PNG
(ethyl N-[3-({6-[(2S)-butan-2-ylcarbamoyl]-5-methyl...)
Show SMILES CCOC(=O)Nc1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)CC)c(C)c23)c1
Show InChI InChI=1S/C22H28N6O3/c1-6-14(4)25-21(29)17-11-28-19(15(17)5)20(23-12-24-28)27-18-10-16(9-8-13(18)3)26-22(30)31-7-2/h8-12,14H,6-7H2,1-5H3,(H,25,29)(H,26,30)(H,23,24,27)/t14-/m0/s1
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n/an/a 5.60n/a 47n/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...


J Med Chem 51: 4-16 (2008)


Article DOI: 10.1021/jm7009414
BindingDB Entry DOI: 10.7270/Q23T9FHB
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194063
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Show SMILES NC(=NCCN1CCNC(=O)C1)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C22H22Cl2N6O3S/c23-13-1-6-16(24)17(11-13)33-15-4-2-14(3-5-15)28-22-19(21(32)29-34-22)20(25)27-8-10-30-9-7-26-18(31)12-30/h1-6,11,28H,7-10,12H2,(H2,25,27)(H,26,31)(H,29,32)
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n/an/an/an/a 49n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibition of MEK-1 activity


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50228870
PNG
(CHEMBL4083065)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)11(16)10(15)6-8/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 49n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50194055
PNG
(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Show SMILES NC(=NCC(O)CO)c1c(Nc2ccc(Oc3cc(Cl)ccc3Cl)cc2)s[nH]c1=O
Show InChI InChI=1S/C19H18Cl2N4O4S/c20-10-1-6-14(21)15(7-10)29-13-4-2-11(3-5-13)24-19-16(18(28)25-30-19)17(22)23-8-12(27)9-26/h1-7,12,24,26-27H,8-9H2,(H2,22,23)(H,25,28)
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n/an/an/an/a 54n/an/an/an/a



Valeant Pharmaceuticals Research & Development

Curated by ChEMBL


Assay Description
Inhibition of MEK-1 activity


Bioorg Med Chem Lett 16: 5561-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.048
BindingDB Entry DOI: 10.7270/Q2J38S5D
More data for this
Ligand-Target Pair
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