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Compile Data Set for Download or QSAR

Found 1940 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229700
PNG
(CHEMBL4085167)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-9-6-10(15)7-11(16)12(9)17/h6-7H,5,8H2,1-4H3
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n/an/an/an/a 12n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM36372
PNG
((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O
Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1
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n/an/an/an/a 18n/an/a7.330



Tufts University



Assay Description
In vitro kinase assay using RIP1


Nat Chem Biol 4: 313-21 (2008)


Article DOI: 10.1038/nchembio.83
BindingDB Entry DOI: 10.7270/Q21V5C91
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229025
PNG
(CHEMBL4092421)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccccc1
Show InChI InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
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n/an/an/an/a 28n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229585
PNG
(CHEMBL4076443)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)ccc1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-8-11(15)6-7-12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 36n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50228870
PNG
(CHEMBL4083065)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)11(16)10(15)6-8/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 49n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229606
PNG
(CHEMBL4072591)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C13H17F2NO2/c1-4-13(2,3)12(17)16(18)8-9-5-6-10(14)11(15)7-9/h5-7,18H,4,8H2,1-3H3
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n/an/an/an/a 56n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229702
PNG
(CHEMBL4101314)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-7-6-8-11(15)12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 58n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50228873
PNG
(CHEMBL4063996)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1
Show InChI InChI=1S/C13H18FNO2/c1-4-13(2,3)12(16)15(17)9-10-5-7-11(14)8-6-10/h5-8,17H,4,9H2,1-3H3
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n/an/an/an/a 64n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229598
PNG
(CHEMBL4096278)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1
Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 72n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229605
PNG
(CHEMBL4061192)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)6-10(15)11(8)16/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 74n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229512
PNG
(CHEMBL4083937)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)C
Show InChI InChI=1S/C13H16F3NO/c1-13(2,3)12(18)17(4)7-8-5-9(14)6-10(15)11(8)16/h5-6H,7H2,1-4H3
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n/an/an/an/a 98n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229699
PNG
(CHEMBL4059584)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1F
Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-8-6-7-9-12(11)15/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 125n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM36371
PNG
(5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...)
Show SMILES CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
Show InChI InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
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n/an/an/an/a 182n/an/a7.330



Tufts University



Assay Description
In vitro kinase assay using RIP1


Nat Chem Biol 4: 313-21 (2008)


Article DOI: 10.1038/nchembio.83
BindingDB Entry DOI: 10.7270/Q21V5C91
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50228872
PNG
(CHEMBL4091760)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1F
Show InChI InChI=1S/C13H17F2NO2/c1-4-13(2,3)12(17)16(18)8-9-5-6-10(14)7-11(9)15/h5-7,18H,4,8H2,1-3H3
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n/an/an/an/a 198n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229541
PNG
(CHEMBL4096270)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccs1
Show InChI InChI=1S/C12H19NOS/c1-5-12(2,3)11(14)13(4)9-10-7-6-8-15-10/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 221n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50228871
PNG
(CHEMBL4099502)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1F
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-6-9(14)11(16)10(8)15/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 262n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229517
PNG
(CHEMBL4068805)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(C)s1
Show InChI InChI=1S/C13H21NOS/c1-6-13(3,4)12(15)14(5)9-11-8-7-10(2)16-11/h7-8H,6,9H2,1-5H3
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n/an/an/an/a 378n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229601
PNG
(CHEMBL4082828)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C14H21NO/c1-5-14(2,3)13(16)15(4)11-12-9-7-6-8-10-12/h6-10H,5,11H2,1-4H3
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n/an/an/an/a 457n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229242
PNG
(CHEMBL4084908)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1
Show InChI InChI=1S/C16H20F3NO/c1-16(6-4-3-5-7-16)15(21)20(2)10-11-8-12(17)9-13(18)14(11)19/h8-9H,3-7,10H2,1-2H3
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n/an/an/an/a 490n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229586
PNG
(CHEMBL4087013)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-6-7-11(15)8-12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 627n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229701
PNG
(CHEMBL4078224)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(Cl)c1
Show InChI InChI=1S/C14H20ClNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 628n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229515
PNG
(CHEMBL4076266)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccco1
Show InChI InChI=1S/C12H19NO2/c1-5-12(2,3)11(14)13(4)9-10-7-6-8-15-10/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 628n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229429
PNG
(CHEMBL4092663)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCC1)C(F)(F)F
Show InChI InChI=1S/C14H13F6NO/c1-21(7-8-5-9(15)6-10(16)11(8)17)12(22)13(3-2-4-13)14(18,19)20/h5-6H,2-4,7H2,1H3
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n/an/an/an/a 656n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229587
PNG
(CHEMBL4080685)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1
Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-6-8-12(15)9-7-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 815n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229603
PNG
(CHEMBL4090332)
Show SMILES CCC(C)(C)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C13H18FNO/c1-4-13(2,3)12(16)15-9-10-7-5-6-8-11(10)14/h5-8H,4,9H2,1-3H3,(H,15,16)
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n/an/an/an/a 898n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229028
PNG
(CHEMBL4066793)
Show SMILES CCC(C)(C)C(=O)NC(CO)c1ccccc1
Show InChI InChI=1S/C14H21NO2/c1-4-14(2,3)13(17)15-12(10-16)11-8-6-5-7-9-11/h5-9,12,16H,4,10H2,1-3H3,(H,15,17)
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n/an/an/an/a 1.08E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229597
PNG
(CHEMBL4104038)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(Br)c1
Show InChI InChI=1S/C14H20BrNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 1.23E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229422
PNG
(CHEMBL4102856)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCCC1)C(F)(F)F
Show InChI InChI=1S/C15H15F6NO/c1-22(8-9-6-10(16)7-11(17)12(9)18)13(23)14(15(19,20)21)4-2-3-5-14/h6-7H,2-5,8H2,1H3
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n/an/an/an/a 1.23E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229583
PNG
(CHEMBL4063537)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1c(F)cc(F)cc1F
Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-10-11(16)6-9(15)7-12(10)17/h6-7H,5,8H2,1-4H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229610
PNG
(CHEMBL4073983)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(C)c(C)s1
Show InChI InChI=1S/C14H23NOS/c1-7-14(4,5)13(16)15(6)9-12-8-10(2)11(3)17-12/h8H,7,9H2,1-6H3
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n/an/an/an/a 1.31E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229609
PNG
(CHEMBL4103563)
Show SMILES CC1CCCC(C)N1C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C16H21F3N2O/c1-10-5-4-6-11(2)21(10)16(22)20(3)9-12-7-13(17)8-14(18)15(12)19/h7-8,10-11H,4-6,9H2,1-3H3
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n/an/an/an/a 1.53E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229552
PNG
(CHEMBL4095647)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccnc1
Show InChI InChI=1S/C13H20N2O/c1-5-13(2,3)12(16)15(4)10-11-7-6-8-14-9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 1.74E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229518
PNG
(CHEMBL4095053)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1sccc1C
Show InChI InChI=1S/C13H21NOS/c1-6-13(3,4)12(15)14(5)9-11-10(2)7-8-16-11/h7-8H,6,9H2,1-5H3
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n/an/an/an/a 2.53E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229187
PNG
(CHEMBL4085631)
Show SMILES CC1CCCCN1C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C15H19F3N2O/c1-10-5-3-4-6-20(10)15(21)19(2)9-11-7-12(16)8-13(17)14(11)18/h7-8,10H,3-6,9H2,1-2H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229588
PNG
(CHEMBL4086116)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(O)c1
Show InChI InChI=1S/C14H21NO2/c1-5-14(2,3)13(17)15(4)10-11-7-6-8-12(16)9-11/h6-9,16H,5,10H2,1-4H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229510
PNG
(CHEMBL4073564)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)CO
Show InChI InChI=1S/C13H16F3NO2/c1-13(2,7-18)12(19)17(3)6-8-4-9(14)5-10(15)11(8)16/h4-5,18H,6-7H2,1-3H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229228
PNG
(CHEMBL4069797)
Show SMILES CC(C)N(C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C13H17F3N2O/c1-8(2)18(4)13(19)17(3)7-9-5-10(14)6-11(15)12(9)16/h5-6,8H,7H2,1-4H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229188
PNG
(CHEMBL4096996)
Show SMILES CC(C)N(C(C)C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C15H21F3N2O/c1-9(2)20(10(3)4)15(21)19(5)8-11-6-12(16)7-13(17)14(11)18/h6-7,9-10H,8H2,1-5H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229604
PNG
(CHEMBL4069288)
Show SMILES CCC(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C13H19NO/c1-4-13(2,3)12(15)14-10-11-8-6-5-7-9-11/h5-9H,4,10H2,1-3H3,(H,14,15)
PDB

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n/an/an/an/a 4.10E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229026
PNG
(CHEMBL4095808)
Show SMILES CCC(C)(C)C(=O)NC1(CC1)c1ccccc1
Show InChI InChI=1S/C15H21NO/c1-4-14(2,3)13(17)16-15(10-11-15)12-8-6-5-7-9-12/h5-9H,4,10-11H2,1-3H3,(H,16,17)
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n/an/an/an/a>5.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229508
PNG
(CHEMBL4064968)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1CCC1
Show InChI InChI=1S/C13H14F3NO/c1-17(13(18)8-3-2-4-8)7-9-5-10(14)6-11(15)12(9)16/h5-6,8H,2-4,7H2,1H3
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n/an/an/an/a 8.24E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229703
PNG
(CHEMBL4080015)
Show SMILES CCC(C)(C)C(=O)NCc1ccccc1Br
Show InChI InChI=1S/C13H18BrNO/c1-4-13(2,3)12(16)15-9-10-7-5-6-8-11(10)14/h5-8H,4,9H2,1-3H3,(H,15,16)
PDB

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n/an/an/an/a 8.56E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229608
PNG
(CHEMBL4088080)
Show SMILES CCC(C)(C)C(=O)NC(C)(C)c1ccccc1
Show InChI InChI=1S/C15H23NO/c1-6-14(2,3)13(17)16-15(4,5)12-10-8-7-9-11-12/h7-11H,6H2,1-5H3,(H,16,17)
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229704
PNG
(CHEMBL4078215)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccncc1F
Show InChI InChI=1S/C13H19FN2O/c1-5-13(2,3)12(17)16(4)9-10-6-7-15-8-11(10)14/h6-8H,5,9H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229607
PNG
(CHEMBL4071625)
Show SMILES CCC(C)(C)C(=O)N(C)C(C)(C)c1ccccc1
Show InChI InChI=1S/C16H25NO/c1-7-15(2,3)14(18)17(6)16(4,5)13-11-9-8-10-12-13/h8-12H,7H2,1-6H3
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229027
PNG
(CHEMBL4077776)
Show SMILES CCC(C)(C)C(=O)N(C)C(CO)c1ccccc1
Show InChI InChI=1S/C15H23NO2/c1-5-15(2,3)14(18)16(4)13(11-17)12-9-7-6-8-10-12/h6-10,13,17H,5,11H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229602
PNG
(CHEMBL4098042)
Show SMILES CCC(C)(C)C(=O)NCc1cccc(Br)c1
Show InChI InChI=1S/C13H18BrNO/c1-4-13(2,3)12(16)15-9-10-6-5-7-11(14)8-10/h5-8H,4,9H2,1-3H3,(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229029
PNG
(CHEMBL4065759)
Show SMILES CCC(C)(C)C(=O)N(C)C(C)c1ccccc1
Show InChI InChI=1S/C15H23NO/c1-6-15(3,4)14(17)16(5)12(2)13-10-8-7-9-11-13/h7-12H,6H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229600
PNG
(CHEMBL4073022)
Show SMILES CCN(Cc1ccccc1F)C(=O)C(C)(C)CC
Show InChI InChI=1S/C15H22FNO/c1-5-15(3,4)14(18)17(6-2)11-12-9-7-8-10-13(12)16/h7-10H,5-6,11H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229599
PNG
(CHEMBL4073019)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1Cl
Show InChI InChI=1S/C14H20ClNO/c1-5-14(2,3)13(17)16(4)10-11-8-6-7-9-12(11)15/h6-9H,5,10H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
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