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Compile Data Set for Download or QSAR

Found 340 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 5'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212260
PNG
(CHEMBL3954836)
Show SMILES CC(C)Oc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1[C@H](C)CO
Show InChI InChI=1S/C21H23N5O3/c1-13(2)29-16-8-7-15-10-25(21(28)17(15)9-16)19-6-4-5-18(23-19)20-24-22-12-26(20)14(3)11-27/h4-9,12-14,27H,10-11H2,1-3H3/t14-/m1/s1
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n/an/an/an/a 6.30n/an/an/an/a



Takeda Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212261
PNG
(CHEMBL3946139)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(OC[C@@H]3CN(C)CCO3)cc2C1=O
Show InChI InChI=1S/C24H28N6O3/c1-16(2)30-15-25-27-23(30)21-5-4-6-22(26-21)29-12-17-7-8-18(11-20(17)24(29)31)33-14-19-13-28(3)9-10-32-19/h4-8,11,15-16,19H,9-10,12-14H2,1-3H3/t19-/m0/s1
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n/an/an/an/a 6.30n/an/an/an/a



Takeda Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212254
PNG
(CHEMBL3975466)
Show SMILES COCCOc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1[C@H](C)CO
Show InChI InChI=1S/C21H23N5O4/c1-14(12-27)26-13-22-24-20(26)18-4-3-5-19(23-18)25-11-15-6-7-16(30-9-8-29-2)10-17(15)21(25)28/h3-7,10,13-14,27H,8-9,11-12H2,1-2H3/t14-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Takeda Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212256
PNG
(CHEMBL3966978)
Show SMILES COCCOc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C21H23N5O3/c1-14(2)26-13-22-24-20(26)18-5-4-6-19(23-18)25-12-15-7-8-16(29-10-9-28-3)11-17(15)21(25)27/h4-8,11,13-14H,9-10,12H2,1-3H3
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n/an/an/an/a 16n/an/an/an/a



Takeda Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212262
PNG
(CHEMBL3937245)
Show SMILES CC(C)Oc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C21H23N5O2/c1-13(2)26-12-22-24-20(26)18-6-5-7-19(23-18)25-11-15-8-9-16(28-14(3)4)10-17(15)21(25)27/h5-10,12-14H,11H2,1-4H3
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n/an/an/an/a 32n/an/an/an/a



Takeda Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431322
PNG
(CHEMBL2346710)
Show SMILES CC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1S/C17H11Cl2NO4S2/c1-8(16(22)23)20-15(21)14(26-17(20)25)7-10-3-5-13(24-10)9-2-4-11(18)12(19)6-9/h2-8H,1H3,(H,22,23)/b14-7-
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340n/an/an/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Competitive inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by Lineweaver-Burk plo...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM32315
PNG
(CHEMBL1345690 | MLS000715851 | SMR000277368 | cid_...)
Show SMILES CCOC(=O)c1c2-c3ccccc3C(=O)c3cccc([nH]c1=O)c23
Show InChI InChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
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500n/an/an/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Competitive inhibition of human ASK1 by Lineweaver-Burk plot analysis


J Med Chem 54: 2680-6 (2011)


Article DOI: 10.1021/jm200117h
BindingDB Entry DOI: 10.7270/Q2ST7Q45
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431294
PNG
(CHEMBL274480)
Show SMILES O=C1NC(=S)S\C1=C/c1cccnc1
Show InChI InChI=1S/C9H6N2OS2/c12-8-7(14-9(13)11-8)4-6-2-1-3-10-5-6/h1-5H,(H,11,12,13)/b7-4-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431295
PNG
(CHEMBL2348829)
Show SMILES SC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNOS2/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431296
PNG
(CHEMBL2348828)
Show SMILES COC(=O)c1ccc(\C=C2/SC(=S)N(C2=O)c2ccc(O)c(c2)C(O)=O)cc1
Show InChI InChI=1S/C19H13NO6S2/c1-26-18(25)11-4-2-10(3-5-11)8-15-16(22)20(19(27)28-15)12-6-7-14(21)13(9-12)17(23)24/h2-9,21H,1H3,(H,23,24)/b15-8-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431297
PNG
(CHEMBL2348827)
Show SMILES OC(=O)C(Cc1ccccc1)N1C(=S)S\C(=C/c2ccncc2)C1=O
Show InChI InChI=1S/C18H14N2O3S2/c21-16-15(11-13-6-8-19-9-7-13)25-18(24)20(16)14(17(22)23)10-12-4-2-1-3-5-12/h1-9,11,14H,10H2,(H,22,23)/b15-11-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431298
PNG
(CHEMBL2348826)
Show SMILES OC(=O)c1ccc(cc1)N1C(=S)S\C(=C/c2cccnc2)C1=O
Show InChI InChI=1S/C16H10N2O3S2/c19-14-13(8-10-2-1-7-17-9-10)23-16(22)18(14)12-5-3-11(4-6-12)15(20)21/h1-9H,(H,20,21)/b13-8-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50679
PNG
((5Z)-5-(2-furanylmethylidene)-3-(3-pyridinyl)-2-su...)
Show SMILES O=C1N(C(=S)S\C1=C/c1ccco1)c1cccnc1
Show InChI InChI=1S/C13H8N2O2S2/c16-12-11(7-10-4-2-6-17-10)19-13(18)15(12)9-3-1-5-14-8-9/h1-8H/b11-7-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431300
PNG
(CHEMBL2349219)
Show SMILES OC(=O)CCCCCN1C(=S)S\C(=C/c2ccc(o2)-c2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C21H18F3NO4S2/c22-21(23,24)14-6-4-5-13(11-14)16-9-8-15(29-16)12-17-19(28)25(20(30)31-17)10-3-1-2-7-18(26)27/h4-6,8-9,11-12H,1-3,7,10H2,(H,26,27)/b17-12-
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n/an/a 500n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431301
PNG
(CHEMBL2348825)
Show SMILES OC(=O)CN1C(=S)S\C(=C/c2ccncc2)C1=O
Show InChI InChI=1S/C11H8N2O3S2/c14-9(15)6-13-10(16)8(18-11(13)17)5-7-1-3-12-4-2-7/h1-5H,6H2,(H,14,15)/b8-5-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431302
PNG
(CHEMBL2349218)
Show SMILES CCCC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)C1=O)C(O)=O
Show InChI InChI=1S/C19H16N2O6S2/c1-2-3-14(18(23)24)20-17(22)16(29-19(20)28)10-13-8-9-15(27-13)11-4-6-12(7-5-11)21(25)26/h4-10,14H,2-3H2,1H3,(H,23,24)/b16-10-
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n/an/a 1.80E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431303
PNG
(CHEMBL2349217)
Show SMILES OC(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)C1=O
Show InChI InChI=1S/C17H12N2O6S2/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24/h1-6,9H,7-8H2,(H,20,21)/b14-9-
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n/an/a 650n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431304
PNG
(CHEMBL1916996)
Show SMILES [O-][N+](=O)c1ccccc1-c1ccc(C=C2SC(S)=NC2=O)o1
Show InChI InChI=1S/C14H8N2O4S2/c17-13-12(22-14(21)15-13)7-8-5-6-11(20-8)9-3-1-2-4-10(9)16(18)19/h1-7H,(H,15,17,21)
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431305
PNG
(CHEMBL2349216)
Show SMILES CCc1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(C(CC(O)=O)C(O)=O)C2=O)o1
Show InChI InChI=1S/C20H17NO6S2/c1-2-11-3-5-12(6-4-11)15-8-7-13(27-15)9-16-18(24)21(20(28)29-16)14(19(25)26)10-17(22)23/h3-9,14H,2,10H2,1H3,(H,22,23)(H,25,26)/b16-9-
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n/an/a 1.80E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431306
PNG
(CHEMBL2349215)
Show SMILES CCOC(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(C(CC(O)=O)C(C)=O)C2=O)o1
Show InChI InChI=1S/C22H19NO7S2/c1-3-29-21(28)14-6-4-13(5-7-14)17-9-8-15(30-17)10-18-20(27)23(22(31)32-18)16(12(2)24)11-19(25)26/h4-10,16H,3,11H2,1-2H3,(H,25,26)/b18-10-
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n/an/a 800n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431307
PNG
(CHEMBL2349214)
Show SMILES COc1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(CC(C)=O)C2=O)o1
Show InChI InChI=1S/C18H15NO4S2/c1-11(20)10-19-17(21)16(25-18(19)24)9-14-7-8-15(23-14)12-3-5-13(22-2)6-4-12/h3-9H,10H2,1-2H3/b16-9-
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n/an/a 2.50E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431308
PNG
(CHEMBL2349221)
Show SMILES COC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C19H16FNO4S2/c1-24-17(22)7-4-10-21-18(23)16(27-19(21)26)11-12-8-9-15(25-12)13-5-2-3-6-14(13)20/h2-3,5-6,8-9,11H,4,7,10H2,1H3/b16-11-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431309
PNG
(CHEMBL2349213)
Show SMILES OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C18H14FNO4S2/c19-13-5-2-1-4-12(13)14-8-7-11(24-14)10-15-17(23)20(18(25)26-15)9-3-6-16(21)22/h1-2,4-5,7-8,10H,3,6,9H2,(H,21,22)/b15-10-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431310
PNG
(CHEMBL2349212)
Show SMILES OC(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C17H12FNO4S2/c18-12-4-2-1-3-11(12)13-6-5-10(23-13)9-14-16(22)19(17(24)25-14)8-7-15(20)21/h1-6,9H,7-8H2,(H,20,21)/b14-9-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431311
PNG
(CHEMBL2349211)
Show SMILES OC(=O)CN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C16H10FNO4S2/c17-11-4-2-1-3-10(11)12-6-5-9(22-12)7-13-15(21)18(8-14(19)20)16(23)24-13/h1-7H,8H2,(H,19,20)/b13-7-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431312
PNG
(CHEMBL2349210)
Show SMILES Oc1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O
Show InChI InChI=1S/C20H12BrNO3S2/c21-13-6-4-12(5-7-13)17-9-8-16(25-17)11-18-19(24)22(20(26)27-18)14-2-1-3-15(23)10-14/h1-11,23H/b18-11-
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n/an/a 2.00E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM8436
PNG
(2-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanyl...)
Show SMILES OC(=O)CN1C(=S)S\C(=C/c2ccco2)C1=O
Show InChI InChI=1S/C10H7NO4S2/c12-8(13)5-11-9(14)7(17-10(11)16)4-6-2-1-3-15-6/h1-4H,5H2,(H,12,13)/b7-4-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM28846
PNG
(2-[(5Z)-5-{[5-(4-bromophenyl)furan-2-yl]methyliden...)
Show SMILES OC(=O)CC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O)C(O)=O
Show InChI InChI=1S/C18H12BrNO6S2/c19-10-3-1-9(2-4-10)13-6-5-11(26-13)7-14-16(23)20(18(27)28-14)12(17(24)25)8-15(21)22/h1-7,12H,8H2,(H,21,22)(H,24,25)/b14-7-
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n/an/a 2.80E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431313
PNG
(CHEMBL2349208)
Show SMILES CCCC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O)C(O)=O
Show InChI InChI=1S/C19H16BrNO4S2/c1-2-3-14(18(23)24)21-17(22)16(27-19(21)26)10-13-8-9-15(25-13)11-4-6-12(20)7-5-11/h4-10,14H,2-3H2,1H3,(H,23,24)/b16-10-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431314
PNG
(CHEMBL2349207)
Show SMILES CCC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O)C(O)=O
Show InChI InChI=1S/C18H14BrNO4S2/c1-2-13(17(22)23)20-16(21)15(26-18(20)25)9-12-7-8-14(24-12)10-3-5-11(19)6-4-10/h3-9,13H,2H2,1H3,(H,22,23)/b15-9-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431315
PNG
(CHEMBL2349206)
Show SMILES OC(=O)CCCCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O
Show InChI InChI=1S/C20H18BrNO4S2/c21-14-7-5-13(6-8-14)16-10-9-15(26-16)12-17-19(25)22(20(27)28-17)11-3-1-2-4-18(23)24/h5-10,12H,1-4,11H2,(H,23,24)/b17-12-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431316
PNG
(CHEMBL2349220)
Show SMILES COC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O
Show InChI InChI=1S/C19H16BrNO4S2/c1-24-17(22)3-2-10-21-18(23)16(27-19(21)26)11-14-8-9-15(25-14)12-4-6-13(20)7-5-12/h4-9,11H,2-3,10H2,1H3/b16-11-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM8434
PNG
(4-[(5Z)-5-{[5-(4-bromophenyl)furan-2-yl]methyliden...)
Show SMILES OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O
Show InChI InChI=1S/C18H14BrNO4S2/c19-12-5-3-11(4-6-12)14-8-7-13(24-14)10-15-17(23)20(18(25)26-15)9-1-2-16(21)22/h3-8,10H,1-2,9H2,(H,21,22)/b15-10-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431317
PNG
(CHEMBL2349204)
Show SMILES Fc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(Cl)c2)C1=O
Show InChI InChI=1S/C20H10Cl2FNO2S2/c21-15-7-1-11(9-16(15)22)17-8-6-14(26-17)10-18-19(25)24(20(27)28-18)13-4-2-12(23)3-5-13/h1-10H/b18-10-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431318
PNG
(CHEMBL2349203)
Show SMILES CSCCC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1S/C19H15Cl2NO4S3/c1-28-7-6-14(18(24)25)22-17(23)16(29-19(22)27)9-11-3-5-15(26-11)10-2-4-12(20)13(21)8-10/h2-5,8-9,14H,6-7H2,1H3,(H,24,25)/b16-9-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431319
PNG
(CHEMBL2349202)
Show SMILES CCCC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1S/C19H15Cl2NO4S2/c1-2-3-14(18(24)25)22-17(23)16(28-19(22)27)9-11-5-7-15(26-11)10-4-6-12(20)13(21)8-10/h4-9,14H,2-3H2,1H3,(H,24,25)/b16-9-
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n/an/a 3.90E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431320
PNG
(CHEMBL2349201)
Show SMILES OC(=O)CC(N1C(=S)S\C(=C/c2ccc(o2)-c2c(Cl)cccc2Cl)C1=O)C(O)=O
Show InChI InChI=1S/C18H11Cl2NO6S2/c19-9-2-1-3-10(20)15(9)12-5-4-8(27-12)6-13-16(24)21(18(28)29-13)11(17(25)26)7-14(22)23/h1-6,11H,7H2,(H,22,23)(H,25,26)/b13-6-
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n/an/a 1.00E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431321
PNG
(CHEMBL2348839)
Show SMILES OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2c(Cl)cccc2Cl)C1=O
Show InChI InChI=1S/C18H13Cl2NO4S2/c19-11-3-1-4-12(20)16(11)13-7-6-10(25-13)9-14-17(24)21(18(26)27-14)8-2-5-15(22)23/h1,3-4,6-7,9H,2,5,8H2,(H,22,23)/b14-9-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431322
PNG
(CHEMBL2346710)
Show SMILES CC(N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1S/C17H11Cl2NO4S2/c1-8(16(22)23)20-15(21)14(26-17(20)25)7-10-3-5-13(24-10)9-2-4-11(18)12(19)6-9/h2-8H,1H3,(H,22,23)/b14-7-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431323
PNG
(CHEMBL2348838)
Show SMILES CCC(N1C(=S)S\C(=C/c2ccc(o2)-c2cc(Cl)ccc2Cl)C1=O)C(O)=O
Show InChI InChI=1S/C18H13Cl2NO4S2/c1-2-13(17(23)24)21-16(22)15(27-18(21)26)8-10-4-6-14(25-10)11-7-9(19)3-5-12(11)20/h3-8,13H,2H2,1H3,(H,23,24)/b15-8-
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n/an/a 500n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431324
PNG
(CHEMBL2348837)
Show SMILES OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2cc(Cl)ccc2Cl)C1=O
Show InChI InChI=1S/C18H13Cl2NO4S2/c19-10-3-5-13(20)12(8-10)14-6-4-11(25-14)9-15-17(24)21(18(26)27-15)7-1-2-16(22)23/h3-6,8-9H,1-2,7H2,(H,22,23)/b15-9-
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n/an/a 350n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431325
PNG
(CHEMBL2348836)
Show SMILES CCC(N1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O)C(O)=O
Show InChI InChI=1S/C18H14ClNO4S2/c1-2-13(17(22)23)20-16(21)15(26-18(20)25)9-12-6-7-14(24-12)10-4-3-5-11(19)8-10/h3-9,13H,2H2,1H3,(H,22,23)/b15-9-
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n/an/a 750n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431326
PNG
(CHEMBL1688850)
Show SMILES OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C18H14ClNO4S2/c19-12-4-1-3-11(9-12)14-7-6-13(24-14)10-15-17(23)20(18(25)26-15)8-2-5-16(21)22/h1,3-4,6-7,9-10H,2,5,8H2,(H,21,22)/b15-10-
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n/an/a 350n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431327
PNG
(CHEMBL2348835)
Show SMILES OC(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C17H12ClNO4S2/c18-11-3-1-2-10(8-11)13-5-4-12(23-13)9-14-16(22)19(17(24)25-14)7-6-15(20)21/h1-5,8-9H,6-7H2,(H,20,21)/b14-9-
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n/an/a 1.00E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431328
PNG
(CHEMBL2348834)
Show SMILES OC(=O)CCCCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2Cl)C1=O
Show InChI InChI=1S/C20H18ClNO4S2/c21-15-7-4-3-6-14(15)16-10-9-13(26-16)12-17-19(25)22(20(27)28-17)11-5-1-2-8-18(23)24/h3-4,6-7,9-10,12H,1-2,5,8,11H2,(H,23,24)/b17-12-
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n/an/a 500n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431329
PNG
(CHEMBL2348833)
Show SMILES OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2Cl)C1=O
Show InChI InChI=1S/C18H14ClNO4S2/c19-13-5-2-1-4-12(13)14-8-7-11(24-14)10-15-17(23)20(18(25)26-15)9-3-6-16(21)22/h1-2,4-5,7-8,10H,3,6,9H2,(H,21,22)/b15-10-
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NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431330
PNG
(CHEMBL2348832)
Show SMILES OC(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2Cl)C1=O
Show InChI InChI=1S/C17H12ClNO4S2/c18-12-4-2-1-3-11(12)13-6-5-10(23-13)9-14-16(22)19(17(24)25-14)8-7-15(20)21/h1-6,9H,7-8H2,(H,20,21)/b14-9-
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n/an/a 750n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431331
PNG
(CHEMBL2348831)
Show SMILES OC(=O)CN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2Cl)C1=O
Show InChI InChI=1S/C16H10ClNO4S2/c17-11-4-2-1-3-10(11)12-6-5-9(22-12)7-13-15(21)18(8-14(19)20)16(23)24-13/h1-7H,8H2,(H,19,20)/b13-7-
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n/an/a 1.25E+3n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM50431332
PNG
(CHEMBL2348830)
Show SMILES Clc1ccc(\C=C2/SC(=S)N(Nc3ccccc3)C2=O)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N2OS2/c17-11-7-6-10(13(18)9-11)8-14-15(21)20(16(22)23-14)19-12-4-2-1-3-5-12/h1-9,19H/b14-8-
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n/an/a>3.30E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...


Eur J Med Chem 61: 104-15 (2013)


Article DOI: 10.1016/j.ejmech.2012.09.022
BindingDB Entry DOI: 10.7270/Q2FX7BTH
More data for this
Ligand-Target Pair
MAP3K5


(Homo sapiens (Human))
BDBM31096
PNG
(CHEMBL290084 | Staurosporine | cid_451705)
Show SMILES CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1
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n/an/an/a 1.10E+5n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q26W98GF
More data for this
Ligand-Target Pair
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