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Compile Data Set for Download or QSAR

Found 649 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 5'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM394380
PNG
((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(3-hydrox...)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C)(O)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9O2S/c1-13(24(25,26)27)36-12-30-33-20(36)22-32-19(8-39-22)31-21(37)15-5-17(34-7-16(29-11-34)14-3-4-14)18(6-28-15)35-9-23(2,38)10-35/h5-8,11-14,38H,3-4,9-10H2,1-2H3,(H,31,37)
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n/an/an/an/a 5.21n/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212260
PNG
(CHEMBL3954836)
Show SMILES CC(C)Oc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1[C@H](C)CO
Show InChI InChI=1/C21H23N5O3/c1-13(2)29-16-8-7-15-10-25(21(28)17(15)9-16)19-6-4-5-18(23-19)20-24-22-12-26(20)14(3)11-27/h4-9,12-14,27H,10-11H2,1-3H3/t14-/s2
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n/an/an/an/a 6.30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
BindingDB Entry DOI: 10.7270/Q2BC41QV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212261
PNG
(CHEMBL3946139)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(OC[C@@H]3CN(C)CCO3)cc2C1=O
Show InChI InChI=1/C24H28N6O3/c1-16(2)30-15-25-27-23(30)21-5-4-6-22(26-21)29-12-17-7-8-18(11-20(17)24(29)31)33-14-19-13-28(3)9-10-32-19/h4-8,11,15-16,19H,9-10,12-14H2,1-3H3/t19-/s2
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n/an/an/an/a 6.30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
BindingDB Entry DOI: 10.7270/Q2BC41QV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM394379
PNG
((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-morpholin...)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCOCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9O2S/c1-14(24(25,26)27)36-13-30-33-21(36)23-32-20(11-39-23)31-22(37)16-8-18(35-10-17(29-12-35)15-2-3-15)19(9-28-16)34-4-6-38-7-5-34/h8-15H,2-7H2,1H3,(H,31,37)
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n/an/an/an/a 6.74n/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM394381
PNG
((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(dimethyl...)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N(C)C)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N9OS/c1-12(22(23,24)25)34-11-28-31-19(34)21-30-18(9-36-21)29-20(35)14-6-16(17(7-26-14)32(2)3)33-8-15(27-10-33)13-4-5-13/h6-13H,4-5H2,1-3H3,(H,29,35)
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n/an/an/an/a 7.12n/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162311
PNG
(US10307427, Compound 2 | US9051313, 2)
Show SMILES CC1(O)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H25N9O2S/c1-24(35)10-32(11-24)19-7-25-16(6-18(19)31-8-17(26-12-31)14-2-3-14)22(34)28-20-9-36-23(29-20)21-30-27-13-33(21)15-4-5-15/h6-9,12-15,35H,2-5,10-11H2,1H3,(H,28,34)
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n/an/an/an/a 11.2n/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212254
PNG
(CHEMBL3975466)
Show SMILES COCCOc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1[C@H](C)CO
Show InChI InChI=1/C21H23N5O4/c1-14(12-27)26-13-22-24-20(26)18-4-3-5-19(23-18)25-11-15-6-7-16(30-9-8-29-2)10-17(15)21(25)28/h3-7,10,13-14,27H,8-9,11-12H2,1-2H3/t14-/s2
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n/an/an/an/a 13n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
BindingDB Entry DOI: 10.7270/Q2BC41QV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162310
PNG
(US10307427, Compound 1 | US9051313, 1)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H25N9O2S/c34-23(28-21-12-36-24(29-21)22-30-27-14-33(22)16-3-4-16)17-9-19(32-11-18(26-13-32)15-1-2-15)20(10-25-17)31-5-7-35-8-6-31/h9-16H,1-8H2,(H,28,34)
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n/an/an/an/a 13.2n/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212256
PNG
(CHEMBL3966978)
Show SMILES COCCOc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C21H23N5O3/c1-14(2)26-13-22-24-20(26)18-5-4-6-19(23-18)25-12-15-7-8-16(29-10-9-28-3)11-17(15)21(25)27/h4-8,11,13-14H,9-10,12H2,1-3H3
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n/an/an/an/a 16n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
BindingDB Entry DOI: 10.7270/Q2BC41QV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50212262
PNG
(CHEMBL3937245)
Show SMILES CC(C)Oc1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C21H23N5O2/c1-13(2)26-12-22-24-20(26)18-6-5-7-19(23-18)25-11-15-8-9-16(28-14(3)4)10-17(15)21(25)27/h5-10,12-14H,11H2,1-4H3
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n/an/an/an/a 32n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...


ACS Med Chem Lett 8: 316-320 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00481
BindingDB Entry DOI: 10.7270/Q2BC41QV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50237288
PNG
(CHEMBL4073198)
Show SMILES COCCn1cc(NC(=O)c2csc(n2)-c2nncn2C(C)C)cn1
Show InChI InChI=1S/C15H19N7O2S/c1-10(2)22-9-16-20-13(22)15-19-12(8-25-15)14(23)18-11-6-17-21(7-11)4-5-24-3/h6-10H,4-5H2,1-3H3,(H,18,23)
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n/an/an/an/a 60n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase II.


Bioorg Med Chem Lett 27: 1709-1713 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.079
BindingDB Entry DOI: 10.7270/Q2J38VV6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50237293
PNG
(CHEMBL4093878)
Show SMILES COCCCn1cc(NC(=O)c2csc(n2)-c2nncn2C(C)C)cn1
Show InChI InChI=1S/C16H21N7O2S/c1-11(2)23-10-17-21-14(23)16-20-13(9-26-16)15(24)19-12-7-18-22(8-12)5-4-6-25-3/h7-11H,4-6H2,1-3H3,(H,19,24)
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n/an/an/an/a 65n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assay


Bioorg Med Chem Lett 27: 1709-1713 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.079
BindingDB Entry DOI: 10.7270/Q2J38VV6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50237289
PNG
(CHEMBL4086119)
Show SMILES COCCNc1ccnc(NC(=O)c2csc(n2)-c2nncn2C(C)C)c1
Show InChI InChI=1S/C17H21N7O2S/c1-11(2)24-10-20-23-15(24)17-21-13(9-27-17)16(25)22-14-8-12(4-5-19-14)18-6-7-26-3/h4-5,8-11H,6-7H2,1-3H3,(H2,18,19,22,25)
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n/an/an/an/a 99n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assay


Bioorg Med Chem Lett 27: 1709-1713 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.079
BindingDB Entry DOI: 10.7270/Q2J38VV6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50237295
PNG
(CHEMBL4081134)
Show SMILES CC(C)n1cnnc1-c1nc(cs1)C(=O)Nc1cnn(c1)C1COC1
Show InChI InChI=1S/C15H17N7O2S/c1-9(2)21-8-16-20-13(21)15-19-12(7-25-15)14(23)18-10-3-17-22(4-10)11-5-24-6-11/h3-4,7-9,11H,5-6H2,1-2H3,(H,18,23)
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n/an/an/an/a 130n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assay


Bioorg Med Chem Lett 27: 1709-1713 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.079
BindingDB Entry DOI: 10.7270/Q2J38VV6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50237294
PNG
(CHEMBL4064613)
Show SMILES COCCOc1ccnc(NC(=O)c2csc(n2)-c2nncn2C(C)C)c1
Show InChI InChI=1S/C17H20N6O3S/c1-11(2)23-10-19-22-15(23)17-20-13(9-27-17)16(24)21-14-8-12(4-5-18-14)26-7-6-25-3/h4-5,8-11H,6-7H2,1-3H3,(H,18,21,24)
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n/an/an/an/a 140n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assay


Bioorg Med Chem Lett 27: 1709-1713 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.079
BindingDB Entry DOI: 10.7270/Q2J38VV6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50237290
PNG
(CHEMBL4084596)
Show SMILES CCn1cc(NC(=O)c2csc(n2)-c2nncn2C(C)C)cn1
Show InChI InChI=1S/C14H17N7OS/c1-4-20-6-10(5-16-20)17-13(22)11-7-23-14(18-11)12-19-15-8-21(12)9(2)3/h5-9H,4H2,1-3H3,(H,17,22)
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n/an/an/an/a 600n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assay


Bioorg Med Chem Lett 27: 1709-1713 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.079
BindingDB Entry DOI: 10.7270/Q2J38VV6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307636
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2cc(ccc12)-c1cc[nH]n1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C21H17N7O/c29-21-16-7-4-13(17-8-9-22-25-17)10-14(16)11-27(21)19-3-1-2-18(24-19)20-26-23-12-28(20)15-5-6-15/h1-4,7-10,12,15H,5-6,11H2,(H,22,25)
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307637
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cn1nccc1-c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-19(9-10-24-27)14-5-8-17-15(11-14)12-28(22(17)30)20-4-2-3-18(25-20)21-26-23-13-29(21)16-6-7-16/h2-5,8-11,13,16H,6-7,12H2,1H3
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307638
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cn1cnc(c1)-c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-11-19(23-12-27)14-5-8-17-15(9-14)10-28(22(17)30)20-4-2-3-18(25-20)21-26-24-13-29(21)16-6-7-16/h2-5,8-9,11-13,16H,6-7,10H2,1H3
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307639
PNG
(5-amino-2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)...)
Show SMILES Nc1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C18H16N6O/c19-12-4-7-14-11(8-12)9-23(18(14)25)16-3-1-2-15(21-16)17-22-20-10-24(17)13-5-6-13/h1-4,7-8,10,13H,5-6,9,19H2
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307642
PNG
(N-(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyrid...)
Show SMILES CN(C)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C20H20N6O/c1-24(2)15-8-9-16-13(10-15)11-25(20(16)27)18-5-3-4-17(22-18)19-23-21-12-26(19)14-6-7-14/h3-5,8-10,12,14H,6-7,11H2,1-2H3
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307643
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES CCNc1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C20H20N6O/c1-2-21-14-6-9-16-13(10-14)11-25(20(16)27)18-5-3-4-17(23-18)19-24-22-12-26(19)15-7-8-15/h3-6,9-10,12,15,21H,2,7-8,11H2,1H3
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307644
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Cn1cncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-12-23-10-19(27)14-5-6-15-11-28(22(30)17(15)9-14)20-4-2-3-18(25-20)21-26-24-13-29(21)16-7-8-16/h2-6,9-10,12-13,16H,7-8,11H2,1H3
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307645
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES O=C1N(Cc2ccc(cc12)-n1ccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C21H17N7O/c29-21-17-10-16(26-9-8-22-12-26)5-4-14(17)11-27(21)19-3-1-2-18(24-19)20-25-23-13-28(20)15-6-7-15/h1-5,8-10,12-13,15H,6-7,11H2
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307646
PNG
(US10150755, Compound 38)
Show SMILES O=C1N(Cc2ccc(cc12)-n1cnc2ccccc12)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H19N7O/c33-25-19-12-18(31-14-26-20-4-1-2-6-22(20)31)9-8-16(19)13-30(25)23-7-3-5-21(28-23)24-29-27-15-32(24)17-10-11-17/h1-9,12,14-15,17H,10-11,13H2
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SEAL ROCK THERAPEUTICS, INC.

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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307647
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Cn1ccc(n1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-10-9-18(26-27)14-5-6-15-12-28(22(30)17(15)11-14)20-4-2-3-19(24-20)21-25-23-13-29(21)16-7-8-16/h2-6,9-11,13,16H,7-8,12H2,1H3
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307648
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H18N6O/c30-23-19-11-15(16-3-2-10-24-12-16)6-7-17(19)13-28(23)21-5-1-4-20(26-21)22-27-25-14-29(22)18-8-9-18/h1-7,10-12,14,18H,8-9,13H2
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307649
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ccncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-9-10-25-12-20(15)16-5-6-17-13-29(24(31)19(17)11-16)22-4-2-3-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307650
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ccc(cn1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-5-6-17(12-25-15)16-7-8-18-13-29(24(31)20(18)11-16)22-4-2-3-21(27-22)23-28-26-14-30(23)19-9-10-19/h2-8,11-12,14,19H,9-10,13H2,1H3
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307651
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cncnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H17N7O/c30-22-18-8-14(16-9-23-12-24-10-16)4-5-15(18)11-28(22)20-3-1-2-19(26-20)21-27-25-13-29(21)17-6-7-17/h1-5,8-10,12-13,17H,6-7,11H2
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307652
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ncc(cn1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H19N7O/c1-14-24-10-17(11-25-14)15-5-6-16-12-29(23(31)19(16)9-15)21-4-2-3-20(27-21)22-28-26-13-30(22)18-7-8-18/h2-6,9-11,13,18H,7-8,12H2,1H3
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307653
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES COc1ccc(cn1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O2/c1-32-22-10-7-16(12-25-22)15-5-6-17-13-29(24(31)19(17)11-15)21-4-2-3-20(27-21)23-28-26-14-30(23)18-8-9-18/h2-7,10-12,14,18H,8-9,13H2,1H3
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SEAL ROCK THERAPEUTICS, INC.

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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307654
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1ccc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H22N6O/c33-26-21-12-17(18-8-11-22(27-13-18)16-4-5-16)6-7-19(21)14-31(26)24-3-1-2-23(29-24)25-30-28-15-32(25)20-9-10-20/h1-3,6-8,11-13,15-16,20H,4-5,9-10,14H2
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307655
PNG
(6-(1-cyclopropyl- 1H-pyrazol-4-yl)-2- (6-(4-cyclop...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnn(c1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H21N7O/c32-24-20-10-15(17-11-26-31(13-17)19-8-9-19)4-5-16(20)12-29(24)22-3-1-2-21(27-22)23-28-25-14-30(23)18-6-7-18/h1-5,10-11,13-14,18-19H,6-9,12H2
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307656
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Fc1ccncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17FN6O/c24-19-8-9-25-11-18(19)14-4-5-15-12-29(23(31)17(15)10-14)21-3-1-2-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307657
PNG
(6-(4-chloropyridin- 3-yl)-2-(6-(4- cyclopropyl-4H-...)
Show SMILES Clc1ccncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17ClN6O/c24-19-8-9-25-11-18(19)14-4-5-15-12-29(23(31)17(15)10-14)21-3-1-2-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307658
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1ccncc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H18N6O/c30-23-19-12-16(15-8-10-24-11-9-15)4-5-17(19)13-28(23)21-3-1-2-20(26-21)22-27-25-14-29(22)18-6-7-18/h1-5,8-12,14,18H,6-7,13H2
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307659
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ncc(s1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H18N6OS/c1-13-23-10-19(30-13)14-5-6-15-11-27(22(29)17(15)9-14)20-4-2-3-18(25-20)21-26-24-12-28(21)16-7-8-16/h2-6,9-10,12,16H,7-8,11H2,1H3
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307660
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ncccc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-19(4-3-11-25-15)16-7-8-17-13-29(24(31)20(17)12-16)22-6-2-5-21(27-22)23-28-26-14-30(23)18-9-10-18/h2-8,11-12,14,18H,9-10,13H2,1H3
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307661
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Fc1ncccc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17FN6O/c24-21-17(3-2-10-25-21)14-6-7-15-12-29(23(31)18(15)11-14)20-5-1-4-19(27-20)22-28-26-13-30(22)16-8-9-16/h1-7,10-11,13,16H,8-9,12H2
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307662
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1cncc(c1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-9-18(12-25-11-15)16-5-6-17-13-29(24(31)20(17)10-16)22-4-2-3-21(27-22)23-28-26-14-30(23)19-7-8-19/h2-6,9-12,14,19H,7-8,13H2,1H3
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307664
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H21N7O/c33-25-20-10-16(18-11-26-23(27-12-18)15-4-5-15)6-7-17(20)13-31(25)22-3-1-2-21(29-22)24-30-28-14-32(24)19-8-9-19/h1-3,6-7,10-12,14-15,19H,4-5,8-9,13H2
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307665
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Cn1ccnc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-10-9-23-20(27)14-5-6-15-12-28(22(30)17(15)11-14)19-4-2-3-18(25-19)21-26-24-13-29(21)16-7-8-16/h2-6,9-11,13,16H,7-8,12H2,1H3
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307666
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1ccccn1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H18N6O/c30-23-18-12-15(19-4-1-2-11-24-19)7-8-16(18)13-28(23)21-6-3-5-20(26-21)22-27-25-14-29(22)17-9-10-17/h1-8,11-12,14,17H,9-10,13H2
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Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307667
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cccnn1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H17N7O/c30-22-17-11-14(18-4-2-10-23-26-18)6-7-15(17)12-28(22)20-5-1-3-19(25-20)21-27-24-13-29(21)16-8-9-16/h1-7,10-11,13,16H,8-9,12H2
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307668
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnc(cn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H21N7O/c33-25-19-10-16(22-12-26-21(11-27-22)15-4-5-15)6-7-17(19)13-31(25)23-3-1-2-20(29-23)24-30-28-14-32(24)18-8-9-18/h1-3,6-7,10-12,14-15,18H,4-5,8-9,13H2
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307654
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1ccc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H22N6O/c33-26-21-12-17(18-8-11-22(27-13-18)16-4-5-16)6-7-19(21)14-31(26)24-3-1-2-23(29-24)25-30-28-15-32(25)20-9-10-20/h1-3,6-8,11-13,15-16,20H,4-5,9-10,14H2
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307670
PNG
(6-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-2-(6-(4-cy...)
Show SMILES O=C1N(Cc2ccc(cc12)-n1cc(nn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H20N8O/c32-23-18-10-17(31-12-20(26-28-31)14-4-5-14)7-6-15(18)11-29(23)21-3-1-2-19(25-21)22-27-24-13-30(22)16-8-9-16/h1-3,6-7,10,12-14,16H,4-5,8-9,11H2
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307671
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Fc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17FN6O/c24-19-9-15-12-29(23(31)18(15)10-17(19)14-3-2-8-25-11-14)21-5-1-4-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
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US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307672
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Cc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-10-17-13-29(24(31)20(17)11-19(15)16-4-3-9-25-12-16)22-6-2-5-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
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SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
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