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Compile Data Set for Download or QSAR

Found 400 hits Enz. Inhib. hit(s) with Target = 'Monocarboxylate transporter 1'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180647
PNG
(CHEMBL3818777)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cnc(NCCCCCNC(=O)[C@@H](N)CCC(N)=O)c4ccccc34)cc12
Show InChI InChI=1S/C34H48N8O4S/c1-22(2)18-28-26-21-42(34(47-17-9-16-43)30(26)33(46)41(3)40-28)20-23-19-39-31(25-11-6-5-10-24(23)25)37-14-7-4-8-15-38-32(45)27(35)12-13-29(36)44/h5-6,10-11,19,21-22,27,43H,4,7-9,12-18,20,35H2,1-3H3,(H2,36,44)(H,37,39)(H,38,45)/t27-/m0/s1
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n/an/an/an/a 0.160n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180648
PNG
(CHEMBL3818150)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccc(C#CCCCOc4ccc(C[C@H](N)C(O)=O)cc4)c4ccccc34)cc12
Show InChI InChI=1S/C39H44N4O5S/c1-26(2)22-35-33-25-43(38(49-21-9-19-44)36(33)37(45)42(3)41-35)24-29-16-15-28(31-11-6-7-12-32(29)31)10-5-4-8-20-48-30-17-13-27(14-18-30)23-34(40)39(46)47/h6-7,11-18,25-26,34,44H,4,8-9,19-24,40H2,1-3H3,(H,46,47)/t34-/m0/s1
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n/an/an/an/a 0.800n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180643
PNG
(CHEMBL3818311)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cnc(NCCCCCN)c4ccccc34)cc12
Show InChI InChI=1S/C29H40N6O2S/c1-20(2)16-25-24-19-35(29(38-15-9-14-36)26(24)28(37)34(3)33-25)18-21-17-32-27(31-13-8-4-7-12-30)23-11-6-5-10-22(21)23/h5-6,10-11,17,19-20,36H,4,7-9,12-16,18,30H2,1-3H3,(H,31,32)
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n/an/an/an/a 0.800n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180645
PNG
(CHEMBL3817951)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cc(NCCCCCNC(=O)[C@@H](N)CCC(N)=O)nc4ccccc34)cc12
Show InChI InChI=1S/C34H48N8O4S/c1-22(2)18-28-25-21-42(34(47-17-9-16-43)31(25)33(46)41(3)40-28)20-23-19-30(39-27-11-6-5-10-24(23)27)37-14-7-4-8-15-38-32(45)26(35)12-13-29(36)44/h5-6,10-11,19,21-22,26,43H,4,7-9,12-18,20,35H2,1-3H3,(H2,36,44)(H,37,39)(H,38,45)/t26-/m0/s1
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n/an/an/an/a 0.800n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180649
PNG
(CHEMBL3818851)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccc(C#CCCCNC(=O)[C@@H](N)CCC(N)=O)c4ccccc34)cc12
Show InChI InChI=1S/C35H44N6O4S/c1-23(2)20-30-28-22-41(35(46-19-9-18-42)32(28)34(45)40(3)39-30)21-25-14-13-24(26-11-6-7-12-27(25)26)10-5-4-8-17-38-33(44)29(36)15-16-31(37)43/h6-7,11-14,22-23,29,42H,4,8-9,15-21,36H2,1-3H3,(H2,37,43)(H,38,44)/t29-/m0/s1
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n/an/an/an/a 4n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22000
PNG
(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12
Show InChI InChI=1S/C25H29N3O2S/c1-17(2)14-22-21-16-28(15-19-10-6-9-18-8-4-5-11-20(18)19)25(31-13-7-12-29)23(21)24(30)27(3)26-22/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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n/an/an/an/a 5n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180650
PNG
(CHEMBL3817902)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccc(Br)c4ccccc34)cc12
Show InChI InChI=1S/C25H28BrN3O2S/c1-16(2)13-22-20-15-29(14-17-9-10-21(26)19-8-5-4-7-18(17)19)25(32-12-6-11-30)23(20)24(31)28(3)27-22/h4-5,7-10,15-16,30H,6,11-14H2,1-3H3
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n/an/an/an/a 11n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180641
PNG
(CHEMBL3818095)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cc(NCCCCCN)nc4ccccc34)cc12
Show InChI InChI=1S/C29H40N6O2S/c1-20(2)16-25-23-19-35(29(38-15-9-14-36)27(23)28(37)34(3)33-25)18-21-17-26(31-13-8-4-7-12-30)32-24-11-6-5-10-22(21)24/h5-6,10-11,17,19-20,36H,4,7-9,12-16,18,30H2,1-3H3,(H,31,32)
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n/an/an/an/a 24n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180638
PNG
(CHEMBL3818980)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cnc(Cl)c4ccccc34)cc12
Show InChI InChI=1S/C24H27ClN4O2S/c1-15(2)11-20-19-14-29(13-16-12-26-22(25)18-8-5-4-7-17(16)18)24(32-10-6-9-30)21(19)23(31)28(3)27-20/h4-5,7-8,12,14-15,30H,6,9-11,13H2,1-3H3
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n/an/an/an/a 55n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180639
PNG
(CHEMBL3818923)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cc(Cl)nc4ccccc34)cc12
Show InChI InChI=1S/C24H27ClN4O2S/c1-15(2)11-20-18-14-29(13-16-12-21(25)26-19-8-5-4-7-17(16)19)24(32-10-6-9-30)22(18)23(31)28(3)27-20/h4-5,7-8,12,14-15,30H,6,9-11,13H2,1-3H3
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n/an/an/an/a 60n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180646
PNG
(CHEMBL3819279)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccc(NCCCCCNC(=O)[C@@H](N)CCC(N)=O)nc3)cc12
Show InChI InChI=1S/C30H46N8O4S/c1-20(2)16-24-22-19-38(30(43-15-7-14-39)27(22)29(42)37(3)36-24)18-21-8-11-26(35-17-21)33-12-5-4-6-13-34-28(41)23(31)9-10-25(32)40/h8,11,17,19-20,23,39H,4-7,9-10,12-16,18,31H2,1-3H3,(H2,32,40)(H,33,35)(H,34,41)/t23-/m0/s1
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n/an/an/an/a 100n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180642
PNG
(CHEMBL3818476)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccc(NCCCCCN)nc3)cc12
Show InChI InChI=1S/C25H38N6O2S/c1-18(2)14-21-20-17-31(25(34-13-7-12-32)23(20)24(33)30(3)29-21)16-19-8-9-22(28-15-19)27-11-6-4-5-10-26/h8-9,15,17-18,32H,4-7,10-14,16,26H2,1-3H3,(H,27,28)
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n/an/an/an/a 420n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180644
PNG
(CHEMBL3818991)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccnc(NCCCCCNC(=O)[C@@H](N)CCC(N)=O)c3)cc12
Show InChI InChI=1S/C30H46N8O4S/c1-20(2)16-24-22-19-38(30(43-15-7-14-39)27(22)29(42)37(3)36-24)18-21-10-13-34-26(17-21)33-11-5-4-6-12-35-28(41)23(31)8-9-25(32)40/h10,13,17,19-20,23,39H,4-9,11-12,14-16,18,31H2,1-3H3,(H2,32,40)(H,33,34)(H,35,41)/t23-/m0/s1
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n/an/an/an/a 500n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180640
PNG
(CHEMBL3819278)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccnc(NCCCCCN)c3)cc12
Show InChI InChI=1S/C25H38N6O2S/c1-18(2)14-21-20-17-31(25(34-13-7-12-32)23(20)24(33)30(3)29-21)16-19-8-11-28-22(15-19)27-10-6-4-5-9-26/h8,11,15,17-18,32H,4-7,9-10,12-14,16,26H2,1-3H3,(H,27,28)
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n/an/an/an/a 520n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180651
PNG
(CHEMBL3819158)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccc(Cl)nc3)cc12
Show InChI InChI=1S/C20H25ClN4O2S/c1-13(2)9-16-15-12-25(11-14-5-6-17(21)22-10-14)20(28-8-4-7-26)18(15)19(27)24(3)23-16/h5-6,10,12-13,26H,4,7-9,11H2,1-3H3
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n/an/an/an/a 690n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50180637
PNG
(CHEMBL3818005)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3ccnc(Cl)c3)cc12
Show InChI InChI=1S/C20H25ClN4O2S/c1-13(2)9-16-15-12-25(11-14-5-6-22-17(21)10-14)20(28-8-4-7-26)18(15)19(27)24(3)23-16/h5-6,10,12-13,26H,4,7-9,11H2,1-3H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assay

Medchemcomm 7: 900-905 (2016)


Article DOI: 10.1039/c5md00579e
BindingDB Entry DOI: 10.7270/Q2GB260N
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21995
PNG
(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C23H24F3N3O5S/c1-12(2)9-28-21-18(19(31)27(3)22(28)33)17(20(32)29-10-14(30)11-34-29)16(35-21)8-13-6-4-5-7-15(13)23(24,25)26/h4-7,12,14,30H,8-11H2,1-3H3/t14-/m0/s1
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 0.0900 -56.8n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22000
PNG
(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12
Show InChI InChI=1S/C25H29N3O2S/c1-17(2)14-22-21-16-28(15-19-10-6-9-18-8-4-5-11-20(18)19)25(31-13-7-12-29)23(21)24(30)27(3)26-22/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.0955n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22000
PNG
(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12
Show InChI InChI=1S/C25H29N3O2S/c1-17(2)14-22-21-16-28(15-19-10-6-9-18-8-4-5-11-20(18)19)25(31-13-7-12-29)23(21)24(30)27(3)26-22/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.100 -56.5n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22001
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2sc(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H28N2O3S2/c1-16(2)15-27-24-21(23(29)26(3)25(27)30)22(31-13-7-12-28)20(32-24)14-18-10-6-9-17-8-4-5-11-19(17)18/h4-6,8-11,16,28H,7,12-15H2,1-3H3
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 0.275n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22001
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2sc(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H28N2O3S2/c1-16(2)15-27-24-21(23(29)26(3)25(27)30)22(31-13-7-12-28)20(32-24)14-18-10-6-9-17-8-4-5-11-19(17)18/h4-6,8-11,16,28H,7,12-15H2,1-3H3
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 0.280 -54.0n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22009
PNG
(5-{[(1R,3R)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(S[C@@H]3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H27F3N2O3S2/c1-13(2)12-29-22-19(21(31)28(3)23(29)32)20(33-16-9-8-15(30)11-16)18(34-22)10-14-6-4-5-7-17(14)24(25,26)27/h4-7,13,15-16,30H,8-12H2,1-3H3/t15-,16-/m1/s1
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 0.290 -53.9n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22001
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2sc(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H28N2O3S2/c1-16(2)15-27-24-21(23(29)26(3)25(27)30)22(31-13-7-12-28)20(32-24)14-18-10-6-9-17-8-4-5-11-19(17)18/h4-6,8-11,16,28H,7,12-15H2,1-3H3
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 0.302n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21992
PNG
(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Show SMILES CC(C)Cn1c2sc(Oc3cccc4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C26H27N3O5S/c1-15(2)13-29-24-20(22(31)27(3)26(29)33)21(23(32)28-12-11-17(30)14-28)25(35-24)34-19-10-6-8-16-7-4-5-9-18(16)19/h4-10,15,17,30H,11-14H2,1-3H3/t17-/m1/s1
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 0.310 -53.7n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM21986
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2cn(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H29N3O3S/c1-17(2)14-28-21-16-27(15-19-10-6-9-18-8-4-5-11-20(18)19)24(32-13-7-12-29)22(21)23(30)26(3)25(28)31/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.330n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21986
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2cn(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H29N3O3S/c1-17(2)14-28-21-16-27(15-19-10-6-9-18-8-4-5-11-20(18)19)24(32-13-7-12-29)22(21)23(30)26(3)25(28)31/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.330 -53.6n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM21986
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2cn(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H29N3O3S/c1-17(2)14-28-21-16-27(15-19-10-6-9-18-8-4-5-11-20(18)19)24(32-13-7-12-29)22(21)23(30)26(3)25(28)31/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.330n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM21986
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2cn(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H29N3O3S/c1-17(2)14-28-21-16-27(15-19-10-6-9-18-8-4-5-11-20(18)19)24(32-13-7-12-29)22(21)23(30)26(3)25(28)31/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.331n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22002
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C22H25F3N2O3S2/c1-13(2)12-27-20-17(19(29)26(3)21(27)30)18(31-10-6-9-28)16(32-20)11-14-7-4-5-8-15(14)22(23,24)25/h4-5,7-8,13,28H,6,9-12H2,1-3H3
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 0.350 -53.4n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22002
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C22H25F3N2O3S2/c1-13(2)12-27-20-17(19(29)26(3)21(27)30)18(31-10-6-9-28)16(32-20)11-14-7-4-5-8-15(14)22(23,24)25/h4-5,7-8,13,28H,6,9-12H2,1-3H3
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 0.355n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22010
PNG
(5-{[(1R,3S)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(S[C@@H]3CC[C@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H27F3N2O3S2/c1-13(2)12-29-22-19(21(31)28(3)23(29)32)20(33-16-9-8-15(30)11-16)18(34-22)10-14-6-4-5-7-17(14)24(25,26)27/h4-7,13,15-16,30H,8-12H2,1-3H3/t15-,16+/m0/s1
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 0.420 -53.0n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21996
PNG
(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Show SMILES CC(C)Cn1c2sc(Cc3c[nH]c4ncccc34)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C23H25N5O5S/c1-12(2)9-27-22-18(20(30)26(3)23(27)32)17(21(31)28-10-14(29)11-33-28)16(34-22)7-13-8-25-19-15(13)5-4-6-24-19/h4-6,8,12,14,29H,7,9-11H2,1-3H3,(H,24,25)/t14-/m0/s1
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 0.430 -52.9n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22002
PNG
(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SCCCO)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C22H25F3N2O3S2/c1-13(2)12-27-20-17(19(29)26(3)21(27)30)18(31-10-6-9-28)16(32-20)11-14-7-4-5-8-15(14)22(23,24)25/h4-5,7-8,13,28H,6,9-12H2,1-3H3
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 0.501n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21994
PNG
(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Show SMILES CC(C)Cn1c2sc(Cc3ccnc4ccccc34)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H26N4O5S/c1-14(2)11-28-24-21(22(31)27(3)25(28)33)20(23(32)29-12-16(30)13-34-29)19(35-24)10-15-8-9-26-18-7-5-4-6-17(15)18/h4-9,14,16,30H,10-13H2,1-3H3/t16-/m0/s1
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 0.520 -52.5n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22011
PNG
(5-{[(1S,3R,4S)-3,4-dihydroxycyclopentyl]sulfanyl}-...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(S[C@H]3C[C@H](O)[C@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H27F3N2O4S2/c1-12(2)11-29-22-19(21(32)28(3)23(29)33)20(34-14-9-16(30)17(31)10-14)18(35-22)8-13-6-4-5-7-15(13)24(25,26)27/h4-7,12,14,16-17,30-31H,8-11H2,1-3H3/t14-,16-,17+
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 0.680 -51.8n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22000
PNG
(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Show SMILES CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12
Show InChI InChI=1S/C25H29N3O2S/c1-17(2)14-22-21-16-28(15-19-10-6-9-18-8-4-5-11-20(18)19)25(31-13-7-12-29)23(21)24(30)27(3)26-22/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3
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 0.708n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22025
PNG
(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Show SMILES CC(C)Cn1c2sc(Cc3c[nH]c4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H28N4O4S/c1-14(2)12-29-24-21(22(31)27(3)25(29)33)20(23(32)28-9-8-16(30)13-28)19(34-24)10-15-11-26-18-7-5-4-6-17(15)18/h4-7,11,14,16,26,30H,8-10,12-13H2,1-3H3/t16-/m1/s1
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 0.790 -51.4n/an/an/an/an/a7.422



AstraZeneca



Assay Description
A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21987
PNG
(6-[(6-fluoroquinolin-4-yl)methyl]-5-{[(3R)-3-hydro...)
Show SMILES CC(C)Cn1c2sc(Cc3ccnc4ccc(F)cc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C26H27FN4O4S/c1-14(2)12-31-25-22(23(33)29(3)26(31)35)21(24(34)30-9-7-17(32)13-30)20(36-25)10-15-6-8-28-19-5-4-16(27)11-18(15)19/h4-6,8,11,14,17,32H,7,9-10,12-13H2,1-3H3/t17-/m1/s1
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 0.810 -51.4n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22014
PNG
(5-{[(3R)-3-hydroxypyrrolidine-1-]sulfonyl}-3-methy...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(c2c(=O)n(C)c1=O)S(=O)(=O)N1CC[C@@H](O)C1
Show InChI InChI=1S/C23H26F3N3O5S2/c1-13(2)11-29-21-18(20(31)27(3)22(29)32)19(36(33,34)28-9-8-15(30)12-28)17(35-21)10-14-6-4-5-7-16(14)23(24,25)26/h4-7,13,15,30H,8-12H2,1-3H3/t15-/m1/s1
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 1.10 -50.6n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21998
PNG
(6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{[(4S)-...)
Show SMILES CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H27N5O5S/c1-10(2)7-25-20-17(18(28)24(5)21(25)30)16(19(29)26-8-13(27)9-31-26)15(32-20)6-14-11(3)22-23-12(14)4/h10,13,27H,6-9H2,1-5H3,(H,22,23)/t13-/m0/s1
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 1.20 -50.4n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21997
PNG
(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Show SMILES CNc1nc2ccccc2n1Cc1sc2n(CC(C)C)c(=O)n(C)c(=O)c2c1C(=O)N1C[C@H](O)CO1
Show InChI InChI=1S/C24H28N6O5S/c1-13(2)9-29-22-19(20(32)27(4)24(29)34)18(21(33)30-10-14(31)12-35-30)17(36-22)11-28-16-8-6-5-7-15(16)26-23(28)25-3/h5-8,13-14,31H,9-12H2,1-4H3,(H,25,26)/t14-/m0/s1
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 1.70 -49.6n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22004
PNG
(3-methyl-1-(2-methylpropyl)-5-(propan-2-ylsulfanyl...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SC(C)C)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C22H25F3N2O2S2/c1-12(2)11-27-20-17(19(28)26(5)21(27)29)18(30-13(3)4)16(31-20)10-14-8-6-7-9-15(14)22(23,24)25/h6-9,12-13H,10-11H2,1-5H3
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 2.20 -48.9n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22008
PNG
(5-{[(1R,2R)-2-hydroxycyclopentyl]sulfanyl}-3-methy...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(S[C@@H]3CCC[C@H]3O)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H27F3N2O3S2/c1-13(2)12-29-22-19(21(31)28(3)23(29)32)20(33-17-10-6-9-16(17)30)18(34-22)11-14-7-4-5-8-15(14)24(25,26)27/h4-5,7-8,13,16-17,30H,6,9-12H2,1-3H3/t16-,17-/m1/s1
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 2.70 -48.4n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM21993
PNG
(6-[(4,5-dichloro-2-methyl-1H-imidazol-1-yl)methyl]...)
Show SMILES CON(C)C(=O)c1c(Cn2c(C)nc(Cl)c2Cl)sc2n(CC(C)C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C19H23Cl2N5O4S/c1-9(2)7-26-18-13(16(27)23(4)19(26)29)12(17(28)24(5)30-6)11(31-18)8-25-10(3)22-14(20)15(25)21/h9H,7-8H2,1-6H3
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 3.20 -48.0n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

J Med Chem 50: 254-63 (2007)


Article DOI: 10.1021/jm060995h
BindingDB Entry DOI: 10.7270/Q2GT5KGF
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22006
PNG
(5-(cyclopentylsulfanyl)-3-methyl-1-(2-methylpropyl...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SC3CCCC3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H27F3N2O2S2/c1-14(2)13-29-22-19(21(30)28(3)23(29)31)20(32-16-9-5-6-10-16)18(33-22)12-15-8-4-7-11-17(15)24(25,26)27/h4,7-8,11,14,16H,5-6,9-10,12-13H2,1-3H3
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 3.20 -48.0n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM22025
PNG
(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Show SMILES CC(C)Cn1c2sc(Cc3c[nH]c4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H28N4O4S/c1-14(2)12-29-24-21(22(31)27(3)25(29)33)20(23(32)28-9-8-16(30)13-28)19(34-24)10-15-11-26-18-7-5-4-6-17(15)18/h4-7,11,14,16,26,30H,8-10,12-13H2,1-3H3/t16-/m1/s1
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 3.20n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM21985
PNG
(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Show SMILES CC(C)Cn1c2sc(Cc3ccnc4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C26H28N4O4S/c1-15(2)13-30-25-22(23(32)28(3)26(30)34)21(24(33)29-11-9-17(31)14-29)20(35-25)12-16-8-10-27-19-7-5-4-6-18(16)19/h4-8,10,15,17,31H,9,11-14H2,1-3H3/t17-/m1/s1
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 3.30n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Homo sapiens (Human))		BDBM50416571
PNG
(CHEMBL1221551)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(C(=O)N3CC=CC3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H24F3N3O3S/c1-14(2)13-30-22-19(20(31)28(3)23(30)33)18(21(32)29-10-6-7-11-29)17(34-22)12-15-8-4-5-9-16(15)24(25,26)27/h4-9,14H,10-13H2,1-3H3
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 3.40n/an/an/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...

Nat Chem Biol 1: 371-6 (2005)


Article DOI: 10.1038/nchembio744
BindingDB Entry DOI: 10.7270/Q2MC9063
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22020
PNG
(5-[(3-hydroxy-3-methylazetidin-1-yl)carbonyl]-3-me...)
Show SMILES CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(C(=O)N3CC(C)(O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C24H26F3N3O4S/c1-13(2)10-30-21-18(19(31)28(4)22(30)33)17(20(32)29-11-23(3,34)12-29)16(35-21)9-14-7-5-6-8-15(14)24(25,26)27/h5-8,13,34H,9-12H2,1-4H3
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 3.5 -47.8n/an/an/an/an/a7.822



AstraZeneca



Assay Description
Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
Monocarboxylate Transporter 1


(Homo sapiens (Human))		BDBM22024
PNG
(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(iso...)
Show SMILES CC(C)Cn1c2sc(Cc3cncc4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C26H28N4O4S/c1-15(2)13-30-25-22(23(32)28(3)26(30)34)21(24(33)29-9-8-18(31)14-29)20(35-25)10-17-12-27-11-16-6-4-5-7-19(16)17/h4-7,11-12,15,18,31H,8-10,13-14H2,1-3H3/t18-/m1/s1
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 3.90 -47.5n/an/an/an/an/a7.422



AstraZeneca



Assay Description
A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...

Bioorg Med Chem Lett 16: 2260-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.024
BindingDB Entry DOI: 10.7270/Q2C24TQK
More data for this
Ligand-Target Pair
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