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Compile Data Set for Download or QSAR

Found 93 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide FF receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM86143
PNG
(L-Val-L-Pro-L-Asn-L-Leu-L-Pro-L-Gln-L-Arg-L-Phe-NH...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
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n/an/an/an/a 1.70n/an/an/an/a



Leipzig University

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation ...


J Med Chem 55: 6124-36 (2012)


Article DOI: 10.1021/jm300535s
BindingDB Entry DOI: 10.7270/Q26974PV
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50414854
PNG
(CHEMBL574565)
Show SMILES NC(N)=NN=Cc1ccc(o1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C13H11F3N4O/c14-13(15,16)10-4-2-1-3-9(10)11-6-5-8(21-11)7-19-20-12(17)18/h1-7H,(H4,17,18,20)
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n/an/an/an/a 39.8n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029138
PNG
(CHEMBL3360830)
Show SMILES CC(C)C[C@@H](N(C)C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)/t37-,38+,39+,40+,41+,42+,43+,44-/m1/s1
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n/an/an/an/a 71n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50336912
PNG
(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
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n/an/an/an/a 71n/an/an/an/a



Leipzig University

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation ...


J Med Chem 55: 6124-36 (2012)


Article DOI: 10.1021/jm300535s
BindingDB Entry DOI: 10.7270/Q26974PV
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50414852
PNG
(CHEMBL573738)
Show SMILES Cc1ccccc1-c1ccc(C=NN=C(N)N)o1
Show InChI InChI=1S/C13H14N4O/c1-9-4-2-3-5-11(9)12-7-6-10(18-12)8-16-17-13(14)15/h2-8H,1H3,(H4,14,15,17)
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n/an/an/an/a 79.4n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50414855
PNG
(CHEMBL573518)
Show SMILES NC(N)=NN=Cc1ccc(s1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C13H11F3N4S/c14-13(15,16)10-4-2-1-3-9(10)11-6-5-8(21-11)7-19-20-12(17)18/h1-7H,(H4,17,18,20)
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n/an/an/an/a 126n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50414853
PNG
(CHEMBL572825)
Show SMILES CC(C)c1ccccc1-c1ccc(C=NN=C(N)N)o1
Show InChI InChI=1S/C15H18N4O/c1-10(2)12-5-3-4-6-13(12)14-8-7-11(20-14)9-18-19-15(16)17/h3-10H,1-2H3,(H4,16,17,19)
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n/an/an/an/a 158n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50082065
PNG
(CHEMBL3422516)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1cn(nn1)[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(O)=O
Show InChI InChI=1S/C89H128N20O18/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-32-78(116)99-68(88(126)127)41-42-77(115)94-43-24-23-30-66(100-83(121)71(98-56(4)111)48-59-35-39-63(113)40-36-59)82(120)104-72(49-60-51-96-65-29-22-21-28-64(60)65)84(122)105-73(50-76(90)114)85(123)106-74(54-110)86(124)103-70(47-57-26-18-17-19-27-57)80(118)97-52-61-53-109(108-107-61)75(45-55(2)3)87(125)101-67(31-25-44-95-89(92)93)81(119)102-69(79(91)117)46-58-33-37-62(112)38-34-58/h17-19,21-22,26-29,33-40,51,53,55,66-75,96,110,112-113H,5-16,20,23-25,30-32,41-50,52,54H2,1-4H3,(H2,90,114)(H2,91,117)(H,94,115)(H,97,118)(H,98,111)(H,99,116)(H,100,121)(H,101,125)(H,102,119)(H,103,124)(H,104,120)(H,105,122)(H,106,123)(H,126,127)(H4,92,93,95)/t66-,67-,68-,69-,70-,71-,72-,73-,74-,75-/m0/s1
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n/an/an/an/a 222n/an/an/an/a



UMR7247; Universit£ Fran£ois Rabelais Tours; IFCE)

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based...


J Med Chem 58: 3459-70 (2015)


Article DOI: 10.1021/jm5019675
BindingDB Entry DOI: 10.7270/Q2JD4ZHJ
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50414856
PNG
(CHEMBL573519)
Show SMILES Cn1c(C=NN=C(N)N)ccc1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C14H14F3N5/c1-22-9(8-20-21-13(18)19)6-7-12(22)10-4-2-3-5-11(10)14(15,16)17/h2-8H,1H3,(H4,18,19,21)
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n/an/an/an/a 316n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50394978
PNG
(CHEMBL573297)
Show SMILES NC(N)=NN=Cc1ccc(Br)c(Br)c1
Show InChI InChI=1S/C8H8Br2N4/c9-6-2-1-5(3-7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)
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n/an/an/an/a 527n/an/an/an/a



Leipzig University

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation ...


J Med Chem 55: 6124-36 (2012)


Article DOI: 10.1021/jm300535s
BindingDB Entry DOI: 10.7270/Q26974PV
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50414850
PNG
(CHEMBL575058)
Show SMILES NC(N)=NN=C(c1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H12Cl2N4/c15-11-7-6-10(8-12(11)16)13(19-20-14(17)18)9-4-2-1-3-5-9/h1-8H,(H4,17,18,20)
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n/an/an/an/a 794n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50394977
PNG
(CHEMBL583068)
Show SMILES NC(N)=NN=Cc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C9H8ClF3N4/c10-7-2-1-5(4-16-17-8(14)15)3-6(7)9(11,12)13/h1-4H,(H4,14,15,17)
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n/an/an/an/a 2.37E+3n/an/an/an/a



Leipzig University

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation ...


J Med Chem 55: 6124-36 (2012)


Article DOI: 10.1021/jm300535s
BindingDB Entry DOI: 10.7270/Q26974PV
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029097
PNG
(CHEMBL3361433)
Show SMILES NC(=N)NCC(=O)NCC1(Cc2cccc3ccccc23)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H33N5O/c28-26(29)30-18-25(33)31-20-27(17-23-11-6-10-22-9-4-5-12-24(22)23)13-15-32(16-14-27)19-21-7-2-1-3-8-21/h1-12H,13-20H2,(H,31,33)(H4,28,29,30)
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n/an/an/an/a 2.60E+3n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation...


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50394977
PNG
(CHEMBL583068)
Show SMILES NC(N)=NN=Cc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C9H8ClF3N4/c10-7-2-1-5(4-16-17-8(14)15)3-6(7)9(11,12)13/h1-4H,(H4,14,15,17)
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n/an/an/an/a>3.16E+3n/an/an/an/a



ACADIA Pharmaceuticals AB

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days


J Med Chem 52: 6511-4 (2009)


Article DOI: 10.1021/jm9011998
BindingDB Entry DOI: 10.7270/Q2G73FZF
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029096
PNG
(CHEMBL3361425)
Show SMILES NC(=N)NCCNC(=O)C1(CCN(Cc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H30N6O/c23-21(24)26-14-13-25-20(29)22(27-19-9-5-2-6-10-19)11-15-28(16-12-22)17-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,25,29)(H4,23,24,26)
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n/an/an/an/a 3.52E+3n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation...


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029111
PNG
(CHEMBL3360829)
Show SMILES CC(=N)NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H39N5O3/c1-17(28)30-9-5-8-22(25(34)31-23(24(29)33)13-18-6-3-2-4-7-18)32-26(35)27-14-19-10-20(15-27)12-21(11-19)16-27/h2-4,6-7,19-23H,5,8-16H2,1H3,(H2,28,30)(H2,29,33)(H,31,34)(H,32,35)/t19?,20?,21?,22-,23-,27?/m0/s1
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n/an/an/an/a 4.70E+3n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced intracellular cAMP accumulation relati...


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50082073
PNG
(CHEMBL3422407)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C65H85N17O16/c1-34(2)24-46(59(93)76-44(14-9-23-71-65(69)70)58(92)77-45(56(68)90)25-37-15-19-40(85)20-16-37)75-55(89)32-73-57(91)47(26-36-10-5-4-6-11-36)78-64(98)52(33-83)82-63(97)51(30-54(67)88)81-61(95)49(28-39-31-72-43-13-8-7-12-42(39)43)79-62(96)50(29-53(66)87)80-60(94)48(74-35(3)84)27-38-17-21-41(86)22-18-38/h4-8,10-13,15-22,31,34,44-52,72,83,85-86H,9,14,23-30,32-33H2,1-3H3,(H2,66,87)(H2,67,88)(H2,68,90)(H,73,91)(H,74,84)(H,75,89)(H,76,93)(H,77,92)(H,78,98)(H,79,96)(H,80,94)(H,81,95)(H,82,97)(H4,69,70,71)/t44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1
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n/an/an/an/a>5.00E+3n/an/an/an/a



UMR7247; Universit£ Fran£ois Rabelais Tours; IFCE)

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based...


J Med Chem 58: 3459-70 (2015)


Article DOI: 10.1021/jm5019675
BindingDB Entry DOI: 10.7270/Q2JD4ZHJ
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50082074
PNG
(CHEMBL3422408)
Show SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)n1cc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)nn1
Show InChI InChI=1S/C66H85N19O15/c1-35(2)24-54(65(100)76-46(14-9-23-72-66(70)71)59(94)77-47(57(69)92)25-38-15-19-42(88)20-16-38)85-33-41(83-84-85)32-74-58(93)48(26-37-10-5-4-6-11-37)78-64(99)53(34-86)82-63(98)52(30-56(68)91)81-61(96)50(28-40-31-73-45-13-8-7-12-44(40)45)79-62(97)51(29-55(67)90)80-60(95)49(75-36(3)87)27-39-17-21-43(89)22-18-39/h4-8,10-13,15-22,31,33,35,46-54,73,86,88-89H,9,14,23-30,32,34H2,1-3H3,(H2,67,90)(H2,68,91)(H2,69,92)(H,74,93)(H,75,87)(H,76,100)(H,77,94)(H,78,99)(H,79,97)(H,80,95)(H,81,96)(H,82,98)(H4,70,71,72)/t46-,47-,48-,49-,50-,51-,52-,53-,54-/m0/s1
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n/an/an/an/a>5.00E+3n/an/an/an/a



UMR7247; Universit£ Fran£ois Rabelais Tours; IFCE)

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based...


J Med Chem 58: 3459-70 (2015)


Article DOI: 10.1021/jm5019675
BindingDB Entry DOI: 10.7270/Q2JD4ZHJ
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50394975
PNG
(CHEMBL2165921)
Show SMILES NC(=N)NN=Cc1ccc(o1)-c1ccc(Br)cc1C(F)(F)F
Show InChI InChI=1S/C13H10BrF3N4O/c14-7-1-3-9(10(5-7)13(15,16)17)11-4-2-8(22-11)6-20-21-12(18)19/h1-6H,(H4,18,19,21)
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n/an/an/an/a 5.62E+3n/an/an/an/a



Leipzig University

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation ...


J Med Chem 55: 6124-36 (2012)


Article DOI: 10.1021/jm300535s
BindingDB Entry DOI: 10.7270/Q26974PV
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029098
PNG
(CHEMBL3361418)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccccc2)CC1)Nc1cccc2ccccc12
Show InChI InChI=1S/C26H32N6O/c27-25(28)29-17-24(33)30-19-26(31-23-12-6-10-21-9-4-5-11-22(21)23)13-15-32(16-14-26)18-20-7-2-1-3-8-20/h1-12,31H,13-19H2,(H,30,33)(H4,27,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced intracellular cAMP accumulation by liquid...


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029109
PNG
(CHEMBL3361419)
Show SMILES COc1cc(NC2(CNC(=O)CNC(N)=N)CCN(Cc3ccccc3)CC2)cc(OC)c1
Show InChI InChI=1S/C24H34N6O3/c1-32-20-12-19(13-21(14-20)33-2)29-24(17-28-22(31)15-27-23(25)26)8-10-30(11-9-24)16-18-6-4-3-5-7-18/h3-7,12-14,29H,8-11,15-17H2,1-2H3,(H,28,31)(H4,25,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Agonist activity at human NPFF1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced intracellular cAMP accumulation by liquid...


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029336
PNG
(CHEMBL3361416)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H30N6O/c23-21(24)25-15-20(29)26-17-22(27-19-9-5-2-6-10-19)11-13-28(14-12-22)16-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,26,29)(H4,23,24,25)
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n/an/an/an/a 2.20E+4n/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation...


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402454
PNG
(CHEMBL2208337)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-10-3-1-4-11-19)34-27(37)23(16-9-17-32-28(30)31)33-26(36)22-15-8-7-14-21(22)20-12-5-2-6-13-20/h1-8,10-15,23-24H,9,16-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402442
PNG
(CHEMBL2208303)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C=Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C24H30N6O3/c25-22(32)20(16-18-10-5-2-6-11-18)30-23(33)19(12-7-15-28-24(26)27)29-21(31)14-13-17-8-3-1-4-9-17/h1-6,8-11,13-14,19-20H,7,12,15-16H2,(H2,25,32)(H,29,31)(H,30,33)(H4,26,27,28)/t19-,20+/m1/s1
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0.800n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402459
PNG
(CHEMBL2208301)
Show SMILES NC(N)=NCCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H35N7O3S/c31-28(39)22(19-20-9-2-1-3-10-20)36-29(40)21(11-8-17-34-30(32)33)35-27(38)16-18-37-23-12-4-6-14-25(23)41-26-15-7-5-13-24(26)37/h1-7,9-10,12-15,21-22H,8,11,16-19H2,(H2,31,39)(H,35,38)(H,36,40)(H4,32,33,34)/t21-,22-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402453
PNG
(CHEMBL2208338)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-10-3-1-4-11-19)34-27(37)23(16-9-17-32-28(30)31)33-26(36)22-15-8-7-14-21(22)20-12-5-2-6-13-20/h1-8,10-15,23-24H,9,16-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24+/m1/s1
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2n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402449
PNG
(CHEMBL2208325)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-8-3-1-4-9-19)34-27(37)23(12-7-17-32-28(30)31)33-26(36)22-15-13-21(14-16-22)20-10-5-2-6-11-20/h1-6,8-11,13-16,23-24H,7,12,17-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24+/m1/s1
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2n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029188
PNG
(CHEMBL2165920)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
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3.70n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029138
PNG
(CHEMBL3360830)
Show SMILES CC(C)C[C@@H](N(C)C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)/t37-,38+,39+,40+,41+,42+,43+,44-/m1/s1
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3.90n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029138
PNG
(CHEMBL3360830)
Show SMILES CC(C)C[C@@H](N(C)C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)/t37-,38+,39+,40+,41+,42+,43+,44-/m1/s1
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4n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [125I]YVP from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402452
PNG
(CHEMBL2208320)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-10-3-1-4-11-19)34-27(37)23(16-9-17-32-28(30)31)33-26(36)22-15-8-7-14-21(22)20-12-5-2-6-13-20/h1-8,10-15,23-24H,9,16-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24-/m1/s1
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5n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402451
PNG
(CHEMBL2208322)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1cccc(c1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(17-19-9-3-1-4-10-19)34-27(37)23(15-8-16-32-28(30)31)33-26(36)22-14-7-13-21(18-22)20-11-5-2-6-12-20/h1-7,9-14,18,23-24H,8,15-17H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24+/m1/s1
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6n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402444
PNG
(CHEMBL2208319)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H34N6O3/c30-26(36)24(19-20-11-4-1-5-12-20)35-27(37)23(17-10-18-33-29(31)32)34-28(38)25(21-13-6-2-7-14-21)22-15-8-3-9-16-22/h1-9,11-16,23-25H,10,17-19H2,(H2,30,36)(H,34,38)(H,35,37)(H4,31,32,33)/t23-,24+/m1/s1
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10n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402457
PNG
(CHEMBL2208340)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C22H28N6O3/c23-19(29)18(14-15-8-3-1-4-9-15)28-21(31)17(12-7-13-26-22(24)25)27-20(30)16-10-5-2-6-11-16/h1-6,8-11,17-18H,7,12-14H2,(H2,23,29)(H,27,30)(H,28,31)(H4,24,25,26)/t17-,18+/m1/s1
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11n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402443
PNG
(CHEMBL2208299)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H34N6O3/c30-26(36)24(19-20-11-4-1-5-12-20)35-27(37)23(17-10-18-33-29(31)32)34-28(38)25(21-13-6-2-7-14-21)22-15-8-3-9-16-22/h1-9,11-16,23-25H,10,17-19H2,(H2,30,36)(H,34,38)(H,35,37)(H4,31,32,33)/t23-,24-/m1/s1
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15n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50336912
PNG
(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
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22n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402458
PNG
(CHEMBL2208339)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C22H28N6O3/c23-19(29)18(14-15-8-3-1-4-9-15)28-21(31)17(12-7-13-26-22(24)25)27-20(30)16-10-5-2-6-11-16/h1-6,8-11,17-18H,7,12-14H2,(H2,23,29)(H,27,30)(H,28,31)(H4,24,25,26)/t17-,18-/m0/s1
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23n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402440
PNG
(CHEMBL2208305)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21+,26?/m1/s1
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29n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402446
PNG
(CHEMBL2208316)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C23H30N6O3/c24-21(31)19(14-16-8-3-1-4-9-16)29-22(32)18(12-7-13-27-23(25)26)28-20(30)15-17-10-5-2-6-11-17/h1-6,8-11,18-19H,7,12-15H2,(H2,24,31)(H,28,30)(H,29,32)(H4,25,26,27)/t18-,19+/m1/s1
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35n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402438
PNG
(CHEMBL2208307)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m1/s1
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51n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029111
PNG
(CHEMBL3360829)
Show SMILES CC(=N)NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H39N5O3/c1-17(28)30-9-5-8-22(25(34)31-23(24(29)33)13-18-6-3-2-4-7-18)32-26(35)27-14-19-10-20(15-27)12-21(11-19)16-27/h2-4,6-7,19-23H,5,8-16H2,1H3,(H2,28,30)(H2,29,33)(H,31,34)(H,32,35)/t19?,20?,21?,22-,23-,27?/m0/s1
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58n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Antagonist activity at human NPFF1 receptor expressed in CHO cells


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029096
PNG
(CHEMBL3361425)
Show SMILES NC(=N)NCCNC(=O)C1(CCN(Cc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H30N6O/c23-21(24)26-14-13-25-20(29)22(27-19-9-5-2-6-10-19)11-15-28(16-12-22)17-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,25,29)(H4,23,24,26)
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81n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402441
PNG
(CHEMBL2208304)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C=Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C24H30N6O3/c25-22(32)20(16-18-10-5-2-6-11-18)30-23(33)19(12-7-15-28-24(26)27)29-21(31)14-13-17-8-3-1-4-9-17/h1-6,8-11,13-14,19-20H,7,12,15-16H2,(H2,25,32)(H,29,31)(H,30,33)(H4,26,27,28)/t19-,20-/m1/s1
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84n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402437
PNG
(CHEMBL2208294)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H30N6O3/c27-23(33)22(16-17-8-2-1-3-9-17)32-25(35)21(14-7-15-30-26(28)29)31-24(34)20-13-6-11-18-10-4-5-12-19(18)20/h1-6,8-13,21-22H,7,14-16H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t21-,22-/m0/s1
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87n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029098
PNG
(CHEMBL3361418)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccccc2)CC1)Nc1cccc2ccccc12
Show InChI InChI=1S/C26H32N6O/c27-25(28)29-17-24(33)30-19-26(31-23-12-6-10-21-9-4-5-11-22(21)23)13-15-32(16-14-26)18-20-7-2-1-3-8-20/h1-12,31H,13-19H2,(H,30,33)(H4,27,28,29)
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94n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402455
PNG
(CHEMBL2208334)
Show SMILES COc1cccc(c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C23H30N6O4/c1-33-17-10-5-9-16(14-17)21(31)28-18(11-6-12-27-23(25)26)22(32)29-19(20(24)30)13-15-7-3-2-4-8-15/h2-5,7-10,14,18-19H,6,11-13H2,1H3,(H2,24,30)(H,28,31)(H,29,32)(H4,25,26,27)/t18-,19-/m0/s1
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106n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402450
PNG
(CHEMBL2208323)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1cccc(c1)-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(17-19-9-3-1-4-10-19)34-27(37)23(15-8-16-32-28(30)31)33-26(36)22-14-7-13-21(18-22)20-11-5-2-6-12-20/h1-7,9-14,18,23-24H,8,15-17H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24-/m1/s1
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110n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029097
PNG
(CHEMBL3361433)
Show SMILES NC(=N)NCC(=O)NCC1(Cc2cccc3ccccc23)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H33N5O/c28-26(29)30-18-25(33)31-20-27(17-23-11-6-10-22-9-4-5-12-24(22)23)13-15-32(16-14-27)19-21-7-2-1-3-8-21/h1-12H,13-20H2,(H,31,33)(H4,28,29,30)
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112n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50029128
PNG
(CHEMBL3361431)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccc(Br)cc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H29BrN6O/c23-18-8-6-17(7-9-18)15-29-12-10-22(11-13-29,28-19-4-2-1-3-5-19)16-27-20(30)14-26-21(24)25/h1-9,28H,10-16H2,(H,27,30)(H4,24,25,26)
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112n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)


Article DOI: 10.1021/jm500989n
BindingDB Entry DOI: 10.7270/Q2C24Z18
More data for this
Ligand-Target Pair
Neuropeptide FF receptor 1


(Homo sapiens)
BDBM50402439
PNG
(CHEMBL2208306)
Show SMILES NC(N)=NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21+,26?/m0/s1
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114n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.049
BindingDB Entry DOI: 10.7270/Q2FF3THX
More data for this
Ligand-Target Pair
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