BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1583 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50240829
PNG
(CHEMBL3559801)
Show SMILES CC(C)(C)c1ccc(OC2CCCCC2O)cc1
Show InChI InChI=1S/C16H24O2/c1-16(2,3)12-8-10-13(11-9-12)18-15-7-5-4-6-14(15)17/h8-11,14-15,17H,4-7H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0398n/an/an/an/a



Leipzig University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Gal...


J Med Chem 60: 7605-7612 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00976
BindingDB Entry DOI: 10.7270/Q22B915R
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466532
PNG
(CHEMBL4281479)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C194H294N54O58/c1-17-99(12)154(243-182(297)143-36-25-73-246(143)187(302)115(196)80-104-37-47-110(252)48-38-104)184(299)227-125(28-18-19-67-195)188(303)247-74-26-34-141(247)180(295)224-122(59-64-149(263)264)158(273)217-102(15)186(301)245-72-24-33-140(245)179(294)213-90-147(260)218-120(58-63-148(261)262)163(278)238-136(88-152(269)270)168(283)216-101(14)157(272)241-139(92-250)189(304)248-75-27-35-142(248)181(296)225-124(61-66-151(267)268)165(280)223-123(60-65-150(265)266)166(281)228-127(77-95(4)5)170(285)236-134(86-145(198)258)175(290)221-116(29-20-68-209-191(200)201)160(275)232-131(82-106-41-51-112(254)52-42-106)173(288)233-130(81-105-39-49-111(253)50-40-105)167(282)215-100(13)156(271)240-138(91-249)178(293)231-126(76-94(2)3)169(284)220-117(30-21-69-210-192(202)203)161(276)235-133(85-109-89-208-93-214-109)174(289)234-132(83-107-43-53-113(255)54-44-107)172(287)229-128(78-96(6)7)171(286)237-135(87-146(199)259)176(291)230-129(79-97(8)9)177(292)242-153(98(10)11)183(298)244-155(103(16)251)185(300)226-119(32-23-71-212-194(206)207)159(274)222-121(57-62-144(197)257)164(279)219-118(31-22-70-211-193(204)205)162(277)239-137(190(305)306)84-108-45-55-114(256)56-46-108/h37-56,89,93-103,115-143,153-155,249-256H,17-36,57-88,90-92,195-196H2,1-16H3,(H2,197,257)(H2,198,258)(H2,199,259)(H,208,214)(H,213,294)(H,215,282)(H,216,283)(H,217,273)(H,218,260)(H,219,279)(H,220,284)(H,221,290)(H,222,274)(H,223,280)(H,224,295)(H,225,296)(H,226,300)(H,227,299)(H,228,281)(H,229,287)(H,230,291)(H,231,293)(H,232,275)(H,233,288)(H,234,289)(H,235,276)(H,236,285)(H,237,286)(H,238,278)(H,239,277)(H,240,271)(H,241,272)(H,242,292)(H,243,297)(H,244,298)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,305,306)(H4,200,201,209)(H4,202,203,210)(H4,204,205,211)(H4,206,207,212)/t99-,100-,101-,102-,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,153-,154-,155-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466532
PNG
(CHEMBL4281479)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C194H294N54O58/c1-17-99(12)154(243-182(297)143-36-25-73-246(143)187(302)115(196)80-104-37-47-110(252)48-38-104)184(299)227-125(28-18-19-67-195)188(303)247-74-26-34-141(247)180(295)224-122(59-64-149(263)264)158(273)217-102(15)186(301)245-72-24-33-140(245)179(294)213-90-147(260)218-120(58-63-148(261)262)163(278)238-136(88-152(269)270)168(283)216-101(14)157(272)241-139(92-250)189(304)248-75-27-35-142(248)181(296)225-124(61-66-151(267)268)165(280)223-123(60-65-150(265)266)166(281)228-127(77-95(4)5)170(285)236-134(86-145(198)258)175(290)221-116(29-20-68-209-191(200)201)160(275)232-131(82-106-41-51-112(254)52-42-106)173(288)233-130(81-105-39-49-111(253)50-40-105)167(282)215-100(13)156(271)240-138(91-249)178(293)231-126(76-94(2)3)169(284)220-117(30-21-69-210-192(202)203)161(276)235-133(85-109-89-208-93-214-109)174(289)234-132(83-107-43-53-113(255)54-44-107)172(287)229-128(78-96(6)7)171(286)237-135(87-146(199)259)176(291)230-129(79-97(8)9)177(292)242-153(98(10)11)183(298)244-155(103(16)251)185(300)226-119(32-23-71-212-194(206)207)159(274)222-121(57-62-144(197)257)164(279)219-118(31-22-70-211-193(204)205)162(277)239-137(190(305)306)84-108-45-55-114(256)56-46-108/h37-56,89,93-103,115-143,153-155,249-256H,17-36,57-88,90-92,195-196H2,1-16H3,(H2,197,257)(H2,198,258)(H2,199,259)(H,208,214)(H,213,294)(H,215,282)(H,216,283)(H,217,273)(H,218,260)(H,219,279)(H,220,284)(H,221,290)(H,222,274)(H,223,280)(H,224,295)(H,225,296)(H,226,300)(H,227,299)(H,228,281)(H,229,287)(H,230,291)(H,231,293)(H,232,275)(H,233,288)(H,234,289)(H,235,276)(H,236,285)(H,237,286)(H,238,278)(H,239,277)(H,240,271)(H,241,272)(H,242,292)(H,243,297)(H,244,298)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,305,306)(H4,200,201,209)(H4,202,203,210)(H4,204,205,211)(H4,206,207,212)/t99-,100-,101-,102-,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,153-,154-,155-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466538
PNG
(CHEMBL4284905)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C189H284N54O58S/c1-15-93(7)148(178(293)232-127(81-140(193)253)167(282)223-122(74-92(5)6)170(285)238-149(94(8)16-2)179(294)239-150(99(13)246)180(295)221-115(31-22-67-207-189(201)202)155(270)219-117(56-59-139(192)252)160(275)217-114(30-21-66-206-188(199)200)158(273)234-132(185(300)301)79-104-44-54-110(251)55-45-104)237-171(286)125(78-103-42-52-109(250)53-43-103)227-166(281)126(80-105-86-203-90-209-105)228-157(272)113(29-20-65-205-187(197)198)218-164(279)121(73-91(3)4)224-173(288)133(88-244)235-153(268)96(10)211-162(277)123(76-101-38-48-107(248)49-39-101)226-165(280)124(77-102-40-50-108(249)51-41-102)225-156(271)112(28-19-64-204-186(195)196)215-151(266)95(9)210-154(269)119(62-72-302-14)220-168(283)129(84-146(262)263)230-161(276)118(58-61-144(258)259)216-152(267)97(11)212-175(290)136-33-24-68-240(136)181(296)98(12)213-163(278)128(83-145(260)261)229-159(274)116(57-60-143(256)257)214-142(255)87-208-174(289)135-32-23-70-242(135)184(299)131(82-141(194)254)233-169(284)130(85-147(264)265)231-176(291)138-35-26-71-243(138)183(298)120(27-17-18-63-190)222-172(287)134(89-245)236-177(292)137-34-25-69-241(137)182(297)111(191)75-100-36-46-106(247)47-37-100/h36-55,86,90-99,111-138,148-150,244-251H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,252)(H2,193,253)(H2,194,254)(H,203,209)(H,208,289)(H,210,269)(H,211,277)(H,212,290)(H,213,278)(H,214,255)(H,215,266)(H,216,267)(H,217,275)(H,218,279)(H,219,270)(H,220,283)(H,221,295)(H,222,287)(H,223,282)(H,224,288)(H,225,271)(H,226,280)(H,227,281)(H,228,272)(H,229,274)(H,230,276)(H,231,291)(H,232,293)(H,233,284)(H,234,273)(H,235,268)(H,236,292)(H,237,286)(H,238,285)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466554
PNG
(CHEMBL4286615)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C187H291N53O56S2/c1-21-93(10)147(176(288)229-126(85-139(193)251)166(278)218-117(65-75-298-20)161(273)223-122(78-91(6)7)169(281)234-148(99(16)241)177(289)221-118(33-25-69-205-187(200)201)179(291)236(18)105(46-59-135(189)247)83-140(252)211-110(30-22-66-202-184(194)195)155(267)231-130(183(295)296)82-104-44-53-109(246)54-45-104)233-170(282)124(80-102-40-49-107(244)50-41-102)226-157(269)112(32-24-68-204-186(198)199)214-156(268)111(31-23-67-203-185(196)197)215-164(276)120(76-89(2)3)224-168(280)128(87-145(260)261)222-152(264)96(13)207-150(262)95(12)209-162(274)123(79-101-38-47-106(243)48-39-101)225-160(272)113(55-60-136(190)248)213-151(263)97(14)208-154(266)116(64-74-297-19)217-158(270)114(56-61-137(191)249)216-159(271)115(57-62-142(254)255)219-172(284)133-36-29-73-240(133)182(294)149(100(17)242)235-153(265)98(15)210-163(275)125(84-138(192)250)227-167(279)127(86-144(258)259)212-141(253)88-206-171(283)131-34-26-71-238(131)181(293)129(81-103-42-51-108(245)52-43-103)230-175(287)146(92(8)9)232-174(286)134-37-28-72-239(134)180(292)119(58-63-143(256)257)220-165(277)121(77-90(4)5)228-173(285)132-35-27-70-237(132)178(290)94(11)188/h38-45,47-54,89-100,105,110-134,146-149,241-246H,21-37,46,55-88,188H2,1-20H3,(H2,189,247)(H2,190,248)(H2,191,249)(H2,192,250)(H2,193,251)(H,206,283)(H,207,262)(H,208,266)(H,209,274)(H,210,275)(H,211,252)(H,212,253)(H,213,263)(H,214,268)(H,215,276)(H,216,271)(H,217,270)(H,218,278)(H,219,284)(H,220,277)(H,221,289)(H,222,264)(H,223,273)(H,224,280)(H,225,272)(H,226,269)(H,227,279)(H,228,285)(H,229,288)(H,230,287)(H,231,267)(H,232,286)(H,233,282)(H,234,281)(H,235,265)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,295,296)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)(H4,200,201,205)/t93-,94-,95-,96-,97-,98-,99+,100+,105-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,146-,147-,148-,149-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466536
PNG
(CHEMBL4279973)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-18-92(12)142(186)170(280)212-114(28-19-20-62-182)175(285)232-68-26-34-131(232)168(278)210-110(53-59-138(247)248)147(257)204-95(15)173(283)231-67-25-33-130(231)166(276)200-83-136(244)205-109(52-58-137(245)246)151(261)224-125(81-141(253)254)155(265)203-94(14)146(256)227-128(85-235)176(286)233-69-27-35-132(233)169(279)211-112(55-61-140(251)252)152(262)208-111(54-60-139(249)250)153(263)214-116(71-88(4)5)157(267)222-123(79-134(184)242)162(272)207-106(29-21-63-196-178(187)188)148(258)218-120(75-98-38-46-103(238)47-39-98)160(270)219-119(74-97-36-44-102(237)45-37-97)154(264)202-93(13)145(255)226-127(84-234)165(275)217-115(70-87(2)3)156(266)206-107(30-22-64-197-179(189)190)149(259)221-122(78-101-82-195-86-201-101)161(271)220-121(76-99-40-48-104(239)49-41-99)159(269)215-117(72-89(6)7)158(268)223-124(80-135(185)243)163(273)216-118(73-90(8)9)164(274)228-143(91(10)11)171(281)229-144(96(16)236)172(282)213-113(32-24-66-199-181(193)194)174(284)230(17)129(56-57-133(183)241)167(277)209-108(31-23-65-198-180(191)192)150(260)225-126(177(287)288)77-100-42-50-105(240)51-43-100/h36-51,82,86-96,106-132,142-144,234-240H,18-35,52-81,83-85,182,186H2,1-17H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,276)(H,202,264)(H,203,265)(H,204,257)(H,205,244)(H,206,266)(H,207,272)(H,208,262)(H,209,277)(H,210,278)(H,211,279)(H,212,280)(H,213,282)(H,214,263)(H,215,269)(H,216,273)(H,217,275)(H,218,258)(H,219,270)(H,220,271)(H,221,259)(H,222,267)(H,223,268)(H,224,261)(H,225,260)(H,226,255)(H,227,256)(H,228,274)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466536
PNG
(CHEMBL4279973)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-18-92(12)142(186)170(280)212-114(28-19-20-62-182)175(285)232-68-26-34-131(232)168(278)210-110(53-59-138(247)248)147(257)204-95(15)173(283)231-67-25-33-130(231)166(276)200-83-136(244)205-109(52-58-137(245)246)151(261)224-125(81-141(253)254)155(265)203-94(14)146(256)227-128(85-235)176(286)233-69-27-35-132(233)169(279)211-112(55-61-140(251)252)152(262)208-111(54-60-139(249)250)153(263)214-116(71-88(4)5)157(267)222-123(79-134(184)242)162(272)207-106(29-21-63-196-178(187)188)148(258)218-120(75-98-38-46-103(238)47-39-98)160(270)219-119(74-97-36-44-102(237)45-37-97)154(264)202-93(13)145(255)226-127(84-234)165(275)217-115(70-87(2)3)156(266)206-107(30-22-64-197-179(189)190)149(259)221-122(78-101-82-195-86-201-101)161(271)220-121(76-99-40-48-104(239)49-41-99)159(269)215-117(72-89(6)7)158(268)223-124(80-135(185)243)163(273)216-118(73-90(8)9)164(274)228-143(91(10)11)171(281)229-144(96(16)236)172(282)213-113(32-24-66-199-181(193)194)174(284)230(17)129(56-57-133(183)241)167(277)209-108(31-23-65-198-180(191)192)150(260)225-126(177(287)288)77-100-42-50-105(240)51-43-100/h36-51,82,86-96,106-132,142-144,234-240H,18-35,52-81,83-85,182,186H2,1-17H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,276)(H,202,264)(H,203,265)(H,204,257)(H,205,244)(H,206,266)(H,207,272)(H,208,262)(H,209,277)(H,210,278)(H,211,279)(H,212,280)(H,213,282)(H,214,263)(H,215,269)(H,216,273)(H,217,275)(H,218,258)(H,219,270)(H,220,271)(H,221,259)(H,222,267)(H,223,268)(H,224,261)(H,225,260)(H,226,255)(H,227,256)(H,228,274)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466538
PNG
(CHEMBL4284905)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C189H284N54O58S/c1-15-93(7)148(178(293)232-127(81-140(193)253)167(282)223-122(74-92(5)6)170(285)238-149(94(8)16-2)179(294)239-150(99(13)246)180(295)221-115(31-22-67-207-189(201)202)155(270)219-117(56-59-139(192)252)160(275)217-114(30-21-66-206-188(199)200)158(273)234-132(185(300)301)79-104-44-54-110(251)55-45-104)237-171(286)125(78-103-42-52-109(250)53-43-103)227-166(281)126(80-105-86-203-90-209-105)228-157(272)113(29-20-65-205-187(197)198)218-164(279)121(73-91(3)4)224-173(288)133(88-244)235-153(268)96(10)211-162(277)123(76-101-38-48-107(248)49-39-101)226-165(280)124(77-102-40-50-108(249)51-41-102)225-156(271)112(28-19-64-204-186(195)196)215-151(266)95(9)210-154(269)119(62-72-302-14)220-168(283)129(84-146(262)263)230-161(276)118(58-61-144(258)259)216-152(267)97(11)212-175(290)136-33-24-68-240(136)181(296)98(12)213-163(278)128(83-145(260)261)229-159(274)116(57-60-143(256)257)214-142(255)87-208-174(289)135-32-23-70-242(135)184(299)131(82-141(194)254)233-169(284)130(85-147(264)265)231-176(291)138-35-26-71-243(138)183(298)120(27-17-18-63-190)222-172(287)134(89-245)236-177(292)137-34-25-69-241(137)182(297)111(191)75-100-36-46-106(247)47-37-100/h36-55,86,90-99,111-138,148-150,244-251H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,252)(H2,193,253)(H2,194,254)(H,203,209)(H,208,289)(H,210,269)(H,211,277)(H,212,290)(H,213,278)(H,214,255)(H,215,266)(H,216,267)(H,217,275)(H,218,279)(H,219,270)(H,220,283)(H,221,295)(H,222,287)(H,223,282)(H,224,288)(H,225,271)(H,226,280)(H,227,281)(H,228,272)(H,229,274)(H,230,276)(H,231,291)(H,232,293)(H,233,284)(H,234,273)(H,235,268)(H,236,292)(H,237,286)(H,238,285)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466554
PNG
(CHEMBL4286615)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C187H291N53O56S2/c1-21-93(10)147(176(288)229-126(85-139(193)251)166(278)218-117(65-75-298-20)161(273)223-122(78-91(6)7)169(281)234-148(99(16)241)177(289)221-118(33-25-69-205-187(200)201)179(291)236(18)105(46-59-135(189)247)83-140(252)211-110(30-22-66-202-184(194)195)155(267)231-130(183(295)296)82-104-44-53-109(246)54-45-104)233-170(282)124(80-102-40-49-107(244)50-41-102)226-157(269)112(32-24-68-204-186(198)199)214-156(268)111(31-23-67-203-185(196)197)215-164(276)120(76-89(2)3)224-168(280)128(87-145(260)261)222-152(264)96(13)207-150(262)95(12)209-162(274)123(79-101-38-47-106(243)48-39-101)225-160(272)113(55-60-136(190)248)213-151(263)97(14)208-154(266)116(64-74-297-19)217-158(270)114(56-61-137(191)249)216-159(271)115(57-62-142(254)255)219-172(284)133-36-29-73-240(133)182(294)149(100(17)242)235-153(265)98(15)210-163(275)125(84-138(192)250)227-167(279)127(86-144(258)259)212-141(253)88-206-171(283)131-34-26-71-238(131)181(293)129(81-103-42-51-108(245)52-43-103)230-175(287)146(92(8)9)232-174(286)134-37-28-72-239(134)180(292)119(58-63-143(256)257)220-165(277)121(77-90(4)5)228-173(285)132-35-27-70-237(132)178(290)94(11)188/h38-45,47-54,89-100,105,110-134,146-149,241-246H,21-37,46,55-88,188H2,1-20H3,(H2,189,247)(H2,190,248)(H2,191,249)(H2,192,250)(H2,193,251)(H,206,283)(H,207,262)(H,208,266)(H,209,274)(H,210,275)(H,211,252)(H,212,253)(H,213,263)(H,214,268)(H,215,276)(H,216,271)(H,217,270)(H,218,278)(H,219,284)(H,220,277)(H,221,289)(H,222,264)(H,223,273)(H,224,280)(H,225,272)(H,226,269)(H,227,279)(H,228,285)(H,229,288)(H,230,287)(H,231,267)(H,232,286)(H,233,282)(H,234,281)(H,235,265)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,295,296)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)(H4,200,201,205)/t93-,94-,95-,96-,97-,98-,99+,100+,105-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,146-,147-,148-,149-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50197025
PNG
(CHEMBL439904 | PYY(3-36))
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C180H279N53O54/c1-17-91(12)141(185)171(282)214-114(27-18-19-61-181)175(286)232-67-25-33-130(232)169(280)211-111(53-58-137(247)248)147(258)204-94(15)174(285)231-66-24-32-129(231)168(279)200-82-135(244)205-109(52-57-136(245)246)152(263)226-126(80-140(253)254)157(268)203-93(14)146(257)228-128(84-235)176(287)233-68-26-34-131(233)170(281)212-113(55-60-139(251)252)154(265)210-112(54-59-138(249)250)155(266)216-117(70-87(4)5)159(270)224-124(78-133(183)242)164(275)208-106(29-21-63-197-178(189)190)150(261)220-121(75-98-39-47-103(239)48-40-98)162(273)221-120(74-97-37-45-102(238)46-38-97)156(267)202-92(13)145(256)227-127(83-234)167(278)219-116(69-86(2)3)158(269)207-107(30-22-64-198-179(191)192)151(262)223-123(77-100-81-195-85-201-100)163(274)222-122(76-99-41-49-104(240)50-42-99)161(272)217-118(71-88(6)7)160(271)225-125(79-134(184)243)165(276)218-119(72-89(8)9)166(277)229-142(90(10)11)172(283)230-143(95(16)236)173(284)213-108(31-23-65-199-180(193)194)148(259)209-110(51-56-132(182)241)153(264)206-105(28-20-62-196-177(187)188)149(260)215-115(144(186)255)73-96-35-43-101(237)44-36-96/h35-50,81,85-95,105-131,141-143,234-240H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,241)(H2,183,242)(H2,184,243)(H2,186,255)(H,195,201)(H,200,279)(H,202,267)(H,203,268)(H,204,258)(H,205,244)(H,206,264)(H,207,269)(H,208,275)(H,209,259)(H,210,265)(H,211,280)(H,212,281)(H,213,284)(H,214,282)(H,215,260)(H,216,266)(H,217,272)(H,218,276)(H,219,278)(H,220,261)(H,221,273)(H,222,274)(H,223,262)(H,224,270)(H,225,271)(H,226,263)(H,227,256)(H,228,257)(H,229,277)(H,230,283)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5.60n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466533
PNG
(CHEMBL4292105)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C180H278N52O55/c1-17-91(12)141(185)170(280)213-114(27-18-19-61-181)174(284)231-67-25-33-130(231)168(278)210-111(53-58-137(246)247)146(256)203-94(15)173(283)230-66-24-32-129(230)167(277)199-82-135(243)204-109(52-57-136(244)245)151(261)224-125(80-140(252)253)156(266)202-93(14)145(255)227-128(84-234)175(285)232-68-26-34-131(232)169(279)211-113(55-60-139(250)251)153(263)209-112(54-59-138(248)249)154(264)214-116(70-87(4)5)158(268)222-123(78-133(183)241)163(273)207-105(28-20-62-195-177(186)187)148(258)218-120(74-97-37-45-102(237)46-38-97)161(271)219-119(73-96-35-43-101(236)44-36-96)155(265)201-92(13)144(254)226-127(83-233)166(276)217-115(69-86(2)3)157(267)206-106(29-21-63-196-178(188)189)149(259)221-122(77-100-81-194-85-200-100)162(272)220-121(75-98-39-47-103(238)48-40-98)160(270)215-117(71-88(6)7)159(269)223-124(79-134(184)242)164(274)216-118(72-89(8)9)165(275)228-142(90(10)11)171(281)229-143(95(16)235)172(282)212-108(31-23-65-198-180(192)193)147(257)208-110(51-56-132(182)240)152(262)205-107(30-22-64-197-179(190)191)150(260)225-126(176(286)287)76-99-41-49-104(239)50-42-99/h35-50,81,85-95,105-131,141-143,233-239H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,240)(H2,183,241)(H2,184,242)(H,194,200)(H,199,277)(H,201,265)(H,202,266)(H,203,256)(H,204,243)(H,205,262)(H,206,267)(H,207,273)(H,208,257)(H,209,263)(H,210,278)(H,211,279)(H,212,282)(H,213,280)(H,214,264)(H,215,270)(H,216,274)(H,217,276)(H,218,258)(H,219,271)(H,220,272)(H,221,259)(H,222,268)(H,223,269)(H,224,261)(H,225,260)(H,226,254)(H,227,255)(H,228,275)(H,229,281)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)(H4,192,193,198)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 16n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466547
PNG
(CHEMBL4278700)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C185H287N53O56S2/c1-20-91(10)144(175(287)228-124(83-137(191)249)165(277)217-116(64-74-296-19)160(272)222-120(77-89(6)7)168(280)233-145(97(16)239)176(288)219-110(32-24-68-203-185(198)199)153(265)214-112(54-59-134(188)246)156(268)212-109(31-23-67-202-184(196)197)155(267)230-128(181(293)294)81-102-43-51-106(244)52-44-102)232-169(281)122(79-100-39-47-104(242)48-40-100)225-154(266)108(30-22-66-201-183(194)195)211-152(264)107(29-21-65-200-182(192)193)213-163(275)118(75-87(2)3)223-167(279)126(85-142(257)258)221-149(261)94(13)205-147(259)93(12)207-161(273)121(78-99-37-45-103(241)46-38-99)224-159(271)111(53-58-133(187)245)210-148(260)95(14)206-151(263)115(63-73-295-18)216-157(269)113(55-60-135(189)247)215-158(270)114(56-61-139(251)252)218-171(283)131-35-28-72-238(131)180(292)146(98(17)240)234-150(262)96(15)208-162(274)123(82-136(190)248)226-166(278)125(84-141(255)256)209-138(250)86-204-170(282)129-33-25-70-236(129)179(291)127(80-101-41-49-105(243)50-42-101)229-174(286)143(90(8)9)231-173(285)132-36-27-71-237(132)178(290)117(57-62-140(253)254)220-164(276)119(76-88(4)5)227-172(284)130-34-26-69-235(130)177(289)92(11)186/h37-52,87-98,107-132,143-146,239-244H,20-36,53-86,186H2,1-19H3,(H2,187,245)(H2,188,246)(H2,189,247)(H2,190,248)(H2,191,249)(H,204,282)(H,205,259)(H,206,263)(H,207,273)(H,208,274)(H,209,250)(H,210,260)(H,211,264)(H,212,268)(H,213,275)(H,214,265)(H,215,270)(H,216,269)(H,217,277)(H,218,283)(H,219,288)(H,220,276)(H,221,261)(H,222,272)(H,223,279)(H,224,271)(H,225,266)(H,226,278)(H,227,284)(H,228,287)(H,229,286)(H,230,267)(H,231,285)(H,232,281)(H,233,280)(H,234,262)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,293,294)(H4,192,193,200)(H4,194,195,201)(H4,196,197,202)(H4,198,199,203)/t91-,92-,93-,94-,95-,96-,97+,98+,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 16n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466547
PNG
(CHEMBL4278700)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C185H287N53O56S2/c1-20-91(10)144(175(287)228-124(83-137(191)249)165(277)217-116(64-74-296-19)160(272)222-120(77-89(6)7)168(280)233-145(97(16)239)176(288)219-110(32-24-68-203-185(198)199)153(265)214-112(54-59-134(188)246)156(268)212-109(31-23-67-202-184(196)197)155(267)230-128(181(293)294)81-102-43-51-106(244)52-44-102)232-169(281)122(79-100-39-47-104(242)48-40-100)225-154(266)108(30-22-66-201-183(194)195)211-152(264)107(29-21-65-200-182(192)193)213-163(275)118(75-87(2)3)223-167(279)126(85-142(257)258)221-149(261)94(13)205-147(259)93(12)207-161(273)121(78-99-37-45-103(241)46-38-99)224-159(271)111(53-58-133(187)245)210-148(260)95(14)206-151(263)115(63-73-295-18)216-157(269)113(55-60-135(189)247)215-158(270)114(56-61-139(251)252)218-171(283)131-35-28-72-238(131)180(292)146(98(17)240)234-150(262)96(15)208-162(274)123(82-136(190)248)226-166(278)125(84-141(255)256)209-138(250)86-204-170(282)129-33-25-70-236(129)179(291)127(80-101-41-49-105(243)50-42-101)229-174(286)143(90(8)9)231-173(285)132-36-27-71-237(132)178(290)117(57-62-140(253)254)220-164(276)119(76-88(4)5)227-172(284)130-34-26-69-235(130)177(289)92(11)186/h37-52,87-98,107-132,143-146,239-244H,20-36,53-86,186H2,1-19H3,(H2,187,245)(H2,188,246)(H2,189,247)(H2,190,248)(H2,191,249)(H,204,282)(H,205,259)(H,206,263)(H,207,273)(H,208,274)(H,209,250)(H,210,260)(H,211,264)(H,212,268)(H,213,275)(H,214,265)(H,215,270)(H,216,269)(H,217,277)(H,218,283)(H,219,288)(H,220,276)(H,221,261)(H,222,272)(H,223,279)(H,224,271)(H,225,266)(H,226,278)(H,227,284)(H,228,287)(H,229,286)(H,230,267)(H,231,285)(H,232,281)(H,233,280)(H,234,262)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,293,294)(H4,192,193,200)(H4,194,195,201)(H4,196,197,202)(H4,198,199,203)/t91-,92-,93-,94-,95-,96-,97+,98+,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 16n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466533
PNG
(CHEMBL4292105)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C180H278N52O55/c1-17-91(12)141(185)170(280)213-114(27-18-19-61-181)174(284)231-67-25-33-130(231)168(278)210-111(53-58-137(246)247)146(256)203-94(15)173(283)230-66-24-32-129(230)167(277)199-82-135(243)204-109(52-57-136(244)245)151(261)224-125(80-140(252)253)156(266)202-93(14)145(255)227-128(84-234)175(285)232-68-26-34-131(232)169(279)211-113(55-60-139(250)251)153(263)209-112(54-59-138(248)249)154(264)214-116(70-87(4)5)158(268)222-123(78-133(183)241)163(273)207-105(28-20-62-195-177(186)187)148(258)218-120(74-97-37-45-102(237)46-38-97)161(271)219-119(73-96-35-43-101(236)44-36-96)155(265)201-92(13)144(254)226-127(83-233)166(276)217-115(69-86(2)3)157(267)206-106(29-21-63-196-178(188)189)149(259)221-122(77-100-81-194-85-200-100)162(272)220-121(75-98-39-47-103(238)48-40-98)160(270)215-117(71-88(6)7)159(269)223-124(79-134(184)242)164(274)216-118(72-89(8)9)165(275)228-142(90(10)11)171(281)229-143(95(16)235)172(282)212-108(31-23-65-198-180(192)193)147(257)208-110(51-56-132(182)240)152(262)205-107(30-22-64-197-179(190)191)150(260)225-126(176(286)287)76-99-41-49-104(239)50-42-99/h35-50,81,85-95,105-131,141-143,233-239H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,240)(H2,183,241)(H2,184,242)(H,194,200)(H,199,277)(H,201,265)(H,202,266)(H,203,256)(H,204,243)(H,205,262)(H,206,267)(H,207,273)(H,208,257)(H,209,263)(H,210,278)(H,211,279)(H,212,282)(H,213,280)(H,214,264)(H,215,270)(H,216,274)(H,217,276)(H,218,258)(H,219,271)(H,220,272)(H,221,259)(H,222,268)(H,223,269)(H,224,261)(H,225,260)(H,226,254)(H,227,255)(H,228,275)(H,229,281)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)(H4,192,193,198)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 16n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466543
PNG
(CHEMBL4276961)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C185H286N52O55S2/c1-20-92(10)144(174(284)226-124(84-137(190)247)163(273)214-115(64-75-294-19)158(268)220-120(78-90(6)7)166(276)231-145(98(16)238)175(285)218-116(33-24-68-202-185(197)198)177(287)235-71-27-36-131(235)169(279)215-110(32-23-67-201-184(195)196)154(264)228-128(181(291)292)82-103-45-53-107(243)54-46-103)230-167(277)122(80-101-41-49-105(241)50-42-101)223-153(263)109(31-22-66-200-183(193)194)210-152(262)108(30-21-65-199-182(191)192)211-161(271)118(76-88(2)3)221-165(275)126(86-142(255)256)219-149(259)95(13)204-147(257)94(12)206-159(269)121(79-100-39-47-104(240)48-40-100)222-157(267)111(55-59-134(187)244)209-148(258)96(14)205-151(261)114(63-74-293-18)213-155(265)112(56-60-135(188)245)212-156(266)113(57-61-139(249)250)216-170(280)132-37-29-73-237(132)180(290)146(99(17)239)232-150(260)97(15)207-160(270)123(83-136(189)246)224-164(274)125(85-141(253)254)208-138(248)87-203-168(278)129-34-25-70-234(129)179(289)127(81-102-43-51-106(242)52-44-102)227-173(283)143(91(8)9)229-172(282)133-38-28-72-236(133)178(288)117(58-62-140(251)252)217-162(272)119(77-89(4)5)225-171(281)130-35-26-69-233(130)176(286)93(11)186/h39-54,88-99,108-133,143-146,238-243H,20-38,55-87,186H2,1-19H3,(H2,187,244)(H2,188,245)(H2,189,246)(H2,190,247)(H,203,278)(H,204,257)(H,205,261)(H,206,269)(H,207,270)(H,208,248)(H,209,258)(H,210,262)(H,211,271)(H,212,266)(H,213,265)(H,214,273)(H,215,279)(H,216,280)(H,217,272)(H,218,285)(H,219,259)(H,220,268)(H,221,275)(H,222,267)(H,223,263)(H,224,274)(H,225,281)(H,226,284)(H,227,283)(H,228,264)(H,229,282)(H,230,277)(H,231,276)(H,232,260)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,291,292)(H4,191,192,199)(H4,193,194,200)(H4,195,196,201)(H4,197,198,202)/t92-,93-,94-,95-,96-,97-,98+,99+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,143-,144-,145-,146-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>30n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466543
PNG
(CHEMBL4276961)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C185H286N52O55S2/c1-20-92(10)144(174(284)226-124(84-137(190)247)163(273)214-115(64-75-294-19)158(268)220-120(78-90(6)7)166(276)231-145(98(16)238)175(285)218-116(33-24-68-202-185(197)198)177(287)235-71-27-36-131(235)169(279)215-110(32-23-67-201-184(195)196)154(264)228-128(181(291)292)82-103-45-53-107(243)54-46-103)230-167(277)122(80-101-41-49-105(241)50-42-101)223-153(263)109(31-22-66-200-183(193)194)210-152(262)108(30-21-65-199-182(191)192)211-161(271)118(76-88(2)3)221-165(275)126(86-142(255)256)219-149(259)95(13)204-147(257)94(12)206-159(269)121(79-100-39-47-104(240)48-40-100)222-157(267)111(55-59-134(187)244)209-148(258)96(14)205-151(261)114(63-74-293-18)213-155(265)112(56-60-135(188)245)212-156(266)113(57-61-139(249)250)216-170(280)132-37-29-73-237(132)180(290)146(99(17)239)232-150(260)97(15)207-160(270)123(83-136(189)246)224-164(274)125(85-141(253)254)208-138(248)87-203-168(278)129-34-25-70-234(129)179(289)127(81-102-43-51-106(242)52-44-102)227-173(283)143(91(8)9)229-172(282)133-38-28-72-236(133)178(288)117(58-62-140(251)252)217-162(272)119(77-89(4)5)225-171(281)130-35-26-69-233(130)176(286)93(11)186/h39-54,88-99,108-133,143-146,238-243H,20-38,55-87,186H2,1-19H3,(H2,187,244)(H2,188,245)(H2,189,246)(H2,190,247)(H,203,278)(H,204,257)(H,205,261)(H,206,269)(H,207,270)(H,208,248)(H,209,258)(H,210,262)(H,211,271)(H,212,266)(H,213,265)(H,214,273)(H,215,279)(H,216,280)(H,217,272)(H,218,285)(H,219,259)(H,220,268)(H,221,275)(H,222,267)(H,223,263)(H,224,274)(H,225,281)(H,226,284)(H,227,283)(H,228,264)(H,229,282)(H,230,277)(H,231,276)(H,232,260)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,291,292)(H4,191,192,199)(H4,193,194,200)(H4,195,196,201)(H4,197,198,202)/t92-,93-,94-,95-,96-,97-,98+,99+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,143-,144-,145-,146-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<32n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466531
PNG
(CHEMBL4277590)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C180H277FN52O54/c1-17-91(12)141(186)170(280)214-114(27-18-19-61-182)174(284)232-67-25-33-130(232)168(278)211-111(53-58-137(246)247)146(256)204-94(15)173(283)231-66-24-32-129(231)167(277)200-82-135(243)205-109(52-57-136(244)245)151(261)225-125(80-140(252)253)156(266)203-93(14)145(255)228-128(84-235)175(285)233-68-26-34-131(233)169(279)212-113(55-60-139(250)251)153(263)210-112(54-59-138(248)249)154(264)215-116(70-87(4)5)158(268)223-123(78-133(184)241)163(273)208-105(28-20-62-196-177(187)188)148(258)219-120(74-98-39-47-103(238)48-40-98)161(271)220-119(73-97-37-45-102(237)46-38-97)155(265)202-92(13)144(254)227-127(83-234)166(276)218-115(69-86(2)3)157(267)207-106(29-21-63-197-178(189)190)149(259)222-122(77-101-81-195-85-201-101)162(272)221-121(75-99-41-49-104(239)50-42-99)160(270)216-117(71-88(6)7)159(269)224-124(79-134(185)242)164(274)217-118(72-89(8)9)165(275)229-142(90(10)11)171(281)230-143(95(16)236)172(282)213-108(31-23-65-199-180(193)194)147(257)209-110(51-56-132(183)240)152(262)206-107(30-22-64-198-179(191)192)150(260)226-126(176(286)287)76-96-35-43-100(181)44-36-96/h35-50,81,85-95,105-131,141-143,234-239H,17-34,51-80,82-84,182,186H2,1-16H3,(H2,183,240)(H2,184,241)(H2,185,242)(H,195,201)(H,200,277)(H,202,265)(H,203,266)(H,204,256)(H,205,243)(H,206,262)(H,207,267)(H,208,273)(H,209,257)(H,210,263)(H,211,278)(H,212,279)(H,213,282)(H,214,280)(H,215,264)(H,216,270)(H,217,274)(H,218,276)(H,219,258)(H,220,271)(H,221,272)(H,222,259)(H,223,268)(H,224,269)(H,225,261)(H,226,260)(H,227,254)(H,228,255)(H,229,275)(H,230,281)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 79n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466531
PNG
(CHEMBL4277590)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C180H277FN52O54/c1-17-91(12)141(186)170(280)214-114(27-18-19-61-182)174(284)232-67-25-33-130(232)168(278)211-111(53-58-137(246)247)146(256)204-94(15)173(283)231-66-24-32-129(231)167(277)200-82-135(243)205-109(52-57-136(244)245)151(261)225-125(80-140(252)253)156(266)203-93(14)145(255)228-128(84-235)175(285)233-68-26-34-131(233)169(279)212-113(55-60-139(250)251)153(263)210-112(54-59-138(248)249)154(264)215-116(70-87(4)5)158(268)223-123(78-133(184)241)163(273)208-105(28-20-62-196-177(187)188)148(258)219-120(74-98-39-47-103(238)48-40-98)161(271)220-119(73-97-37-45-102(237)46-38-97)155(265)202-92(13)144(254)227-127(83-234)166(276)218-115(69-86(2)3)157(267)207-106(29-21-63-197-178(189)190)149(259)222-122(77-101-81-195-85-201-101)162(272)221-121(75-99-41-49-104(239)50-42-99)160(270)216-117(71-88(6)7)159(269)224-124(79-134(185)242)164(274)217-118(72-89(8)9)165(275)229-142(90(10)11)171(281)230-143(95(16)236)172(282)213-108(31-23-65-199-180(193)194)147(257)209-110(51-56-132(183)240)152(262)206-107(30-22-64-198-179(191)192)150(260)226-126(176(286)287)76-96-35-43-100(181)44-36-96/h35-50,81,85-95,105-131,141-143,234-239H,17-34,51-80,82-84,182,186H2,1-16H3,(H2,183,240)(H2,184,241)(H2,185,242)(H,195,201)(H,200,277)(H,202,265)(H,203,266)(H,204,256)(H,205,243)(H,206,262)(H,207,267)(H,208,273)(H,209,257)(H,210,263)(H,211,278)(H,212,279)(H,213,282)(H,214,280)(H,215,264)(H,216,270)(H,217,274)(H,218,276)(H,219,258)(H,220,271)(H,221,272)(H,222,259)(H,223,268)(H,224,269)(H,225,261)(H,226,260)(H,227,254)(H,228,255)(H,229,275)(H,230,281)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 79n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466544
PNG
(CHEMBL4294277)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-17-92(12)143(186)171(281)214-115(27-18-19-61-182)175(285)232-67-25-33-131(232)169(279)211-112(53-58-139(248)249)148(258)204-95(15)174(284)231-66-24-32-130(231)168(278)200-83-137(245)207-111(52-57-138(246)247)153(263)225-126(81-142(254)255)157(267)203-94(14)147(257)228-129(85-235)176(286)233-68-26-34-132(233)170(280)212-114(55-60-141(252)253)154(264)210-113(54-59-140(250)251)155(265)215-117(70-88(4)5)159(269)223-124(79-134(184)242)164(274)209-109(30-22-64-198-180(191)192)151(261)219-121(74-98-37-46-104(238)47-38-98)162(272)220-120(73-97-35-44-103(237)45-36-97)156(266)202-93(13)146(256)227-128(84-234)167(277)218-116(69-87(2)3)158(268)208-110(31-23-65-199-181(193)194)152(262)222-123(77-102-82-195-86-201-102)163(273)221-122(75-99-39-48-105(239)49-40-99)161(271)216-118(71-89(6)7)160(270)224-125(80-135(185)243)165(275)217-119(72-90(8)9)166(276)229-144(91(10)11)172(282)230-145(96(16)236)173(283)213-108(29-21-63-197-179(189)190)149(259)205-101(43-56-133(183)241)78-136(244)206-107(28-20-62-196-178(187)188)150(260)226-127(177(287)288)76-100-41-50-106(240)51-42-100/h35-42,44-51,82,86-96,101,107-132,143-145,234-240H,17-34,43,52-81,83-85,182,186H2,1-16H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,278)(H,202,266)(H,203,267)(H,204,258)(H,205,259)(H,206,244)(H,207,245)(H,208,268)(H,209,274)(H,210,264)(H,211,279)(H,212,280)(H,213,283)(H,214,281)(H,215,265)(H,216,271)(H,217,275)(H,218,277)(H,219,261)(H,220,272)(H,221,273)(H,222,262)(H,223,269)(H,224,270)(H,225,263)(H,226,260)(H,227,256)(H,228,257)(H,229,276)(H,230,282)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,101-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 126n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466544
PNG
(CHEMBL4294277)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-17-92(12)143(186)171(281)214-115(27-18-19-61-182)175(285)232-67-25-33-131(232)169(279)211-112(53-58-139(248)249)148(258)204-95(15)174(284)231-66-24-32-130(231)168(278)200-83-137(245)207-111(52-57-138(246)247)153(263)225-126(81-142(254)255)157(267)203-94(14)147(257)228-129(85-235)176(286)233-68-26-34-132(233)170(280)212-114(55-60-141(252)253)154(264)210-113(54-59-140(250)251)155(265)215-117(70-88(4)5)159(269)223-124(79-134(184)242)164(274)209-109(30-22-64-198-180(191)192)151(261)219-121(74-98-37-46-104(238)47-38-98)162(272)220-120(73-97-35-44-103(237)45-36-97)156(266)202-93(13)146(256)227-128(84-234)167(277)218-116(69-87(2)3)158(268)208-110(31-23-65-199-181(193)194)152(262)222-123(77-102-82-195-86-201-102)163(273)221-122(75-99-39-48-105(239)49-40-99)161(271)216-118(71-89(6)7)160(270)224-125(80-135(185)243)165(275)217-119(72-90(8)9)166(276)229-144(91(10)11)172(282)230-145(96(16)236)173(283)213-108(29-21-63-197-179(189)190)149(259)205-101(43-56-133(183)241)78-136(244)206-107(28-20-62-196-178(187)188)150(260)226-127(177(287)288)76-100-41-50-106(240)51-42-100/h35-42,44-51,82,86-96,101,107-132,143-145,234-240H,17-34,43,52-81,83-85,182,186H2,1-16H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,278)(H,202,266)(H,203,267)(H,204,258)(H,205,259)(H,206,244)(H,207,245)(H,208,268)(H,209,274)(H,210,264)(H,211,279)(H,212,280)(H,213,283)(H,214,281)(H,215,265)(H,216,271)(H,217,275)(H,218,277)(H,219,261)(H,220,272)(H,221,273)(H,222,262)(H,223,269)(H,224,270)(H,225,263)(H,226,260)(H,227,256)(H,228,257)(H,229,276)(H,230,282)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,101-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 130n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444587
PNG
(CHEMBL3099724)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H273N53O54/c1-16-88(10)138(182)168(279)212-112(26-17-18-60-178)172(283)229-66-24-32-127(229)166(277)209-109(52-57-134(244)245)145(256)202-92(14)171(282)228-65-23-31-126(228)165(276)197-80-132(241)203-107(51-56-133(242)243)150(261)223-123(78-137(250)251)156(267)200-90(12)143(254)225-125(82-232)173(284)230-67-25-33-128(230)167(278)210-111(54-59-136(248)249)152(263)208-110(53-58-135(246)247)153(264)214-115(69-85(4)5)158(269)222-122(77-131(181)240)163(274)206-104(28-20-62-194-175(186)187)148(259)217-118(73-96-38-46-101(236)47-39-96)161(272)218-117(72-95-36-44-100(235)45-37-95)154(265)199-89(11)142(253)224-124(81-231)164(275)216-114(68-84(2)3)157(268)205-105(29-21-63-195-176(188)189)149(260)220-120(75-98-79-192-83-198-98)162(273)219-119(74-97-40-48-102(237)49-41-97)160(271)215-116(70-86(6)7)159(270)221-121(76-130(180)239)155(266)201-91(13)144(255)226-139(87(8)9)169(280)227-140(93(15)233)170(281)211-106(30-22-64-196-177(190)191)146(257)207-108(50-55-129(179)238)151(262)204-103(27-19-61-193-174(184)185)147(258)213-113(141(183)252)71-94-34-42-99(234)43-35-94/h34-49,79,83-93,103-128,138-140,231-237H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,238)(H2,180,239)(H2,181,240)(H2,183,252)(H,192,198)(H,197,276)(H,199,265)(H,200,267)(H,201,266)(H,202,256)(H,203,241)(H,204,262)(H,205,268)(H,206,274)(H,207,257)(H,208,263)(H,209,277)(H,210,278)(H,211,281)(H,212,279)(H,213,258)(H,214,264)(H,215,271)(H,216,275)(H,217,259)(H,218,272)(H,219,273)(H,220,260)(H,221,270)(H,222,269)(H,223,261)(H,224,253)(H,225,254)(H,226,255)(H,227,280)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 135n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444589
PNG
(CHEMBL3099723)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)O[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)210-110(26-17-18-60-178)171(281)228-66-24-32-126(228)164(274)207-107(51-57-134(243)244)145(255)202-92(14)170(280)227-65-23-31-125(227)163(273)197-80-132(240)203-106(50-56-133(241)242)149(259)222-122(78-137(249)250)154(264)200-90(12)143(253)224-124(82-231)172(282)229-67-25-33-127(229)165(275)208-109(53-59-136(247)248)150(260)206-108(52-58-135(245)246)151(261)213-114(69-85(4)5)156(266)221-121(77-131(181)239)161(271)205-103(27-19-61-193-174(184)185)147(257)216-117(73-96-38-46-101(235)47-39-96)159(269)217-116(72-95-36-44-100(234)45-37-95)152(262)199-89(11)142(252)223-123(81-230)162(272)215-113(68-84(2)3)155(265)204-104(28-20-62-194-175(186)187)148(258)219-119(75-98-79-192-83-198-98)160(270)218-118(74-97-40-48-102(236)49-41-97)158(268)214-115(70-86(6)7)157(267)220-120(76-130(180)238)153(263)201-91(13)144(254)225-139(87(8)9)168(278)226-140(93(15)232)169(279)211-111(30-22-64-196-177(190)191)173(283)284-128(54-55-129(179)237)166(276)209-105(29-21-63-195-176(188)189)146(256)212-112(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,273)(H,199,262)(H,200,264)(H,201,263)(H,202,255)(H,203,240)(H,204,265)(H,205,271)(H,206,260)(H,207,274)(H,208,275)(H,209,276)(H,210,277)(H,211,279)(H,212,256)(H,213,261)(H,214,268)(H,215,272)(H,216,257)(H,217,269)(H,218,270)(H,219,258)(H,220,267)(H,221,266)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,278)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 144n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444587
PNG
(CHEMBL3099724)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H273N53O54/c1-16-88(10)138(182)168(279)212-112(26-17-18-60-178)172(283)229-66-24-32-127(229)166(277)209-109(52-57-134(244)245)145(256)202-92(14)171(282)228-65-23-31-126(228)165(276)197-80-132(241)203-107(51-56-133(242)243)150(261)223-123(78-137(250)251)156(267)200-90(12)143(254)225-125(82-232)173(284)230-67-25-33-128(230)167(278)210-111(54-59-136(248)249)152(263)208-110(53-58-135(246)247)153(264)214-115(69-85(4)5)158(269)222-122(77-131(181)240)163(274)206-104(28-20-62-194-175(186)187)148(259)217-118(73-96-38-46-101(236)47-39-96)161(272)218-117(72-95-36-44-100(235)45-37-95)154(265)199-89(11)142(253)224-124(81-231)164(275)216-114(68-84(2)3)157(268)205-105(29-21-63-195-176(188)189)149(260)220-120(75-98-79-192-83-198-98)162(273)219-119(74-97-40-48-102(237)49-41-97)160(271)215-116(70-86(6)7)159(270)221-121(76-130(180)239)155(266)201-91(13)144(255)226-139(87(8)9)169(280)227-140(93(15)233)170(281)211-106(30-22-64-196-177(190)191)146(257)207-108(50-55-129(179)238)151(262)204-103(27-19-61-193-174(184)185)147(258)213-113(141(183)252)71-94-34-42-99(234)43-35-94/h34-49,79,83-93,103-128,138-140,231-237H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,238)(H2,180,239)(H2,181,240)(H2,183,252)(H,192,198)(H,197,276)(H,199,265)(H,200,267)(H,201,266)(H,202,256)(H,203,241)(H,204,262)(H,205,268)(H,206,274)(H,207,257)(H,208,263)(H,209,277)(H,210,278)(H,211,281)(H,212,279)(H,213,258)(H,214,264)(H,215,271)(H,216,275)(H,217,259)(H,218,272)(H,219,273)(H,220,260)(H,221,270)(H,222,269)(H,223,261)(H,224,253)(H,225,254)(H,226,255)(H,227,280)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 164n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444592
PNG
(CHEMBL3099721)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)O[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)211-111(26-17-18-60-178)171(281)228-66-24-32-126(228)165(275)208-108(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-31-125(227)164(274)197-80-132(240)203-106(51-56-133(241)242)149(259)222-122(78-137(249)250)155(265)200-90(12)143(253)224-124(82-231)172(282)229-67-25-33-127(229)166(276)209-110(54-59-136(247)248)150(260)207-109(53-58-135(245)246)152(262)213-114(69-85(4)5)157(267)221-121(77-131(181)239)162(272)205-103(27-19-61-193-174(184)185)147(257)216-117(72-95-36-44-100(234)45-37-95)160(270)217-116(71-94-34-42-99(233)43-35-94)153(263)199-89(11)142(252)223-123(81-230)163(273)215-113(68-84(2)3)156(266)204-104(28-20-62-194-175(186)187)148(258)219-119(75-98-79-192-83-198-98)161(271)218-118(73-96-38-46-101(235)47-39-96)159(269)214-115(70-86(6)7)158(268)220-120(76-130(180)238)154(264)201-91(13)144(254)225-139(87(8)9)168(278)226-140(93(15)232)169(279)210-105(29-21-63-195-176(188)189)146(256)206-107(50-55-129(179)237)151(261)212-112(30-22-64-196-177(190)191)173(283)284-128(141(183)251)74-97-40-48-102(236)49-41-97/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,274)(H,199,263)(H,200,265)(H,201,264)(H,202,255)(H,203,240)(H,204,266)(H,205,272)(H,206,256)(H,207,260)(H,208,275)(H,209,276)(H,210,279)(H,211,277)(H,212,261)(H,213,262)(H,214,269)(H,215,273)(H,216,257)(H,217,270)(H,218,271)(H,219,258)(H,220,268)(H,221,267)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,278)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 222n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50185364
PNG
(CHEMBL2371908 | CHEMBL415187 | Sub[-Tyr-Arg-Leu-Ar...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C80H122N24O18/c1-43(2)37-59(71(115)95-57(15-9-35-93-79(87)88)69(113)103-63(75(119)120)41-47-21-29-51(107)30-22-47)101-67(111)55(13-7-33-91-77(83)84)97-73(117)61(39-45-17-25-49(105)26-18-45)99-65(109)53(81)11-5-6-12-54(82)66(110)100-62(40-46-19-27-50(106)28-20-46)74(118)98-56(14-8-34-92-78(85)86)68(112)102-60(38-44(3)4)72(116)96-58(16-10-36-94-80(89)90)70(114)104-64(76(121)122)42-48-23-31-52(108)32-24-48/h17-32,43-44,53-64,105-108H,5-16,33-42,81-82H2,1-4H3,(H,95,115)(H,96,116)(H,97,117)(H,98,118)(H,99,109)(H,100,110)(H,101,111)(H,102,112)(H,103,113)(H,104,114)(H,119,120)(H,121,122)(H4,83,84,91)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t53?,54?,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 240n/an/an/an/a



University of Cincinnati

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Factor Xa


J Med Chem 49: 2661-5 (2006)


Article DOI: 10.1021/jm050907d
BindingDB Entry DOI: 10.7270/Q2XS5TZ9
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466535
PNG
(CHEMBL4280392)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-18-92(12)142(186)170(280)213-113(28-19-20-62-182)175(285)232-68-26-34-131(232)168(278)209-110(54-59-138(247)248)147(257)204-95(15)173(283)231-67-25-33-130(231)166(276)200-83-136(244)205-109(53-58-137(245)246)151(261)224-125(81-141(253)254)155(265)203-94(14)146(256)227-128(85-235)176(286)233-69-27-35-132(233)169(279)210-112(56-61-140(251)252)152(262)208-111(55-60-139(249)250)153(263)214-116(71-88(4)5)157(267)222-123(79-134(184)242)162(272)207-106(29-21-63-196-178(187)188)149(259)218-120(75-98-38-46-103(238)47-39-98)160(270)219-119(74-97-36-44-102(237)45-37-97)154(264)202-93(13)145(255)226-127(84-234)165(275)217-115(70-87(2)3)156(266)206-107(30-22-64-197-179(189)190)150(260)221-122(78-101-82-195-86-201-101)161(271)220-121(76-99-40-48-104(239)49-41-99)159(269)215-117(72-89(6)7)158(268)223-124(80-135(185)243)163(273)216-118(73-90(8)9)164(274)228-143(91(10)11)171(281)229-144(96(16)236)172(282)211-108(31-23-65-198-180(191)192)148(258)212-114(52-57-133(183)241)174(284)230(17)129(32-24-66-199-181(193)194)167(277)225-126(177(287)288)77-100-42-50-105(240)51-43-100/h36-51,82,86-96,106-132,142-144,234-240H,18-35,52-81,83-85,182,186H2,1-17H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,276)(H,202,264)(H,203,265)(H,204,257)(H,205,244)(H,206,266)(H,207,272)(H,208,262)(H,209,278)(H,210,279)(H,211,282)(H,212,258)(H,213,280)(H,214,263)(H,215,269)(H,216,273)(H,217,275)(H,218,259)(H,219,270)(H,220,271)(H,221,260)(H,222,267)(H,223,268)(H,224,261)(H,225,277)(H,226,255)(H,227,256)(H,228,274)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 316n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466524
PNG
(CHEMBL4277676)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-17-92(12)143(186)171(281)216-116(27-18-19-61-182)175(285)232-67-25-33-131(232)169(279)213-113(53-58-139(248)249)148(258)204-95(15)174(284)231-66-24-32-130(231)168(278)200-83-137(245)206-111(52-57-138(246)247)153(263)225-126(81-142(254)255)158(268)203-94(14)147(257)228-129(85-235)176(286)233-68-26-34-132(233)170(280)214-115(55-60-141(252)253)155(265)212-114(54-59-140(250)251)156(266)217-120(72-90(8)9)161(271)224-125(80-135(185)243)165(275)210-107(28-20-62-196-178(187)188)150(260)220-122(74-98-37-45-104(238)46-38-98)163(273)221-121(73-97-35-43-103(237)44-36-97)157(267)202-93(13)146(256)227-128(84-234)167(277)219-119(71-89(6)7)160(270)209-108(29-21-63-197-179(189)190)151(261)223-124(77-102-82-195-86-201-102)164(274)222-123(75-99-39-47-105(239)48-40-99)162(272)218-118(70-88(4)5)159(269)205-101(78-134(184)242)79-136(244)207-117(69-87(2)3)166(276)229-144(91(10)11)172(282)230-145(96(16)236)173(283)215-110(31-23-65-199-181(193)194)149(259)211-112(51-56-133(183)241)154(264)208-109(30-22-64-198-180(191)192)152(262)226-127(177(287)288)76-100-41-49-106(240)50-42-100/h35-50,82,86-96,101,107-132,143-145,234-240H,17-34,51-81,83-85,182,186H2,1-16H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,278)(H,202,267)(H,203,268)(H,204,258)(H,205,269)(H,206,245)(H,207,244)(H,208,264)(H,209,270)(H,210,275)(H,211,259)(H,212,265)(H,213,279)(H,214,280)(H,215,283)(H,216,281)(H,217,266)(H,218,272)(H,219,277)(H,220,260)(H,221,273)(H,222,274)(H,223,261)(H,224,271)(H,225,263)(H,226,262)(H,227,256)(H,228,257)(H,229,276)(H,230,282)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,101-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 316n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466535
PNG
(CHEMBL4280392)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-18-92(12)142(186)170(280)213-113(28-19-20-62-182)175(285)232-68-26-34-131(232)168(278)209-110(54-59-138(247)248)147(257)204-95(15)173(283)231-67-25-33-130(231)166(276)200-83-136(244)205-109(53-58-137(245)246)151(261)224-125(81-141(253)254)155(265)203-94(14)146(256)227-128(85-235)176(286)233-69-27-35-132(233)169(279)210-112(56-61-140(251)252)152(262)208-111(55-60-139(249)250)153(263)214-116(71-88(4)5)157(267)222-123(79-134(184)242)162(272)207-106(29-21-63-196-178(187)188)149(259)218-120(75-98-38-46-103(238)47-39-98)160(270)219-119(74-97-36-44-102(237)45-37-97)154(264)202-93(13)145(255)226-127(84-234)165(275)217-115(70-87(2)3)156(266)206-107(30-22-64-197-179(189)190)150(260)221-122(78-101-82-195-86-201-101)161(271)220-121(76-99-40-48-104(239)49-41-99)159(269)215-117(72-89(6)7)158(268)223-124(80-135(185)243)163(273)216-118(73-90(8)9)164(274)228-143(91(10)11)171(281)229-144(96(16)236)172(282)211-108(31-23-65-198-180(191)192)148(258)212-114(52-57-133(183)241)174(284)230(17)129(32-24-66-199-181(193)194)167(277)225-126(177(287)288)77-100-42-50-105(240)51-43-100/h36-51,82,86-96,106-132,142-144,234-240H,18-35,52-81,83-85,182,186H2,1-17H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,276)(H,202,264)(H,203,265)(H,204,257)(H,205,244)(H,206,266)(H,207,272)(H,208,262)(H,209,278)(H,210,279)(H,211,282)(H,212,258)(H,213,280)(H,214,263)(H,215,269)(H,216,273)(H,217,275)(H,218,259)(H,219,270)(H,220,271)(H,221,260)(H,222,267)(H,223,268)(H,224,261)(H,225,277)(H,226,255)(H,227,256)(H,228,274)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 320n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466524
PNG
(CHEMBL4277676)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-17-92(12)143(186)171(281)216-116(27-18-19-61-182)175(285)232-67-25-33-131(232)169(279)213-113(53-58-139(248)249)148(258)204-95(15)174(284)231-66-24-32-130(231)168(278)200-83-137(245)206-111(52-57-138(246)247)153(263)225-126(81-142(254)255)158(268)203-94(14)147(257)228-129(85-235)176(286)233-68-26-34-132(233)170(280)214-115(55-60-141(252)253)155(265)212-114(54-59-140(250)251)156(266)217-120(72-90(8)9)161(271)224-125(80-135(185)243)165(275)210-107(28-20-62-196-178(187)188)150(260)220-122(74-98-37-45-104(238)46-38-98)163(273)221-121(73-97-35-43-103(237)44-36-97)157(267)202-93(13)146(256)227-128(84-234)167(277)219-119(71-89(6)7)160(270)209-108(29-21-63-197-179(189)190)151(261)223-124(77-102-82-195-86-201-102)164(274)222-123(75-99-39-47-105(239)48-40-99)162(272)218-118(70-88(4)5)159(269)205-101(78-134(184)242)79-136(244)207-117(69-87(2)3)166(276)229-144(91(10)11)172(282)230-145(96(16)236)173(283)215-110(31-23-65-199-181(193)194)149(259)211-112(51-56-133(183)241)154(264)208-109(30-22-64-198-180(191)192)152(262)226-127(177(287)288)76-100-41-49-106(240)50-42-100/h35-50,82,86-96,101,107-132,143-145,234-240H,17-34,51-81,83-85,182,186H2,1-16H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,278)(H,202,267)(H,203,268)(H,204,258)(H,205,269)(H,206,245)(H,207,244)(H,208,264)(H,209,270)(H,210,275)(H,211,259)(H,212,265)(H,213,279)(H,214,280)(H,215,283)(H,216,281)(H,217,266)(H,218,272)(H,219,277)(H,220,260)(H,221,273)(H,222,274)(H,223,261)(H,224,271)(H,225,263)(H,226,262)(H,227,256)(H,228,257)(H,229,276)(H,230,282)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,101-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 320n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444588
PNG
(CHEMBL3099722)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)210-110(26-17-18-60-178)171(281)228-66-24-31-126(228)164(274)207-107(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-30-125(227)163(273)197-80-132(240)203-106(51-56-133(241)242)149(259)222-122(78-137(249)250)154(264)200-90(12)143(253)224-124(82-231)172(282)229-67-25-32-127(229)165(275)208-109(54-59-136(247)248)150(260)206-108(53-58-135(245)246)151(261)213-114(69-85(4)5)156(266)221-121(77-131(181)239)161(271)205-103(27-19-61-193-174(184)185)147(257)216-117(73-96-38-46-101(235)47-39-96)159(269)217-116(72-95-36-44-100(234)45-37-95)152(262)199-89(11)142(252)223-123(81-230)162(272)215-113(68-84(2)3)155(265)204-104(28-20-62-194-175(186)187)148(258)219-119(75-98-79-192-83-198-98)160(270)218-118(74-97-40-48-102(236)49-41-97)158(268)214-115(70-86(6)7)157(267)220-120(76-130(180)238)153(263)201-91(13)144(254)225-139(87(8)9)168(278)226-140(93(15)232)169(279)209-105(29-21-63-195-176(188)189)146(256)211-111(50-55-129(179)237)173(283)284-128(33-22-64-196-177(190)191)166(276)212-112(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,273)(H,199,262)(H,200,264)(H,201,263)(H,202,255)(H,203,240)(H,204,265)(H,205,271)(H,206,260)(H,207,274)(H,208,275)(H,209,279)(H,210,277)(H,211,256)(H,212,276)(H,213,261)(H,214,268)(H,215,272)(H,216,257)(H,217,269)(H,218,270)(H,219,258)(H,220,267)(H,221,266)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,278)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 380n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444591
PNG
(CHEMBL3099726)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)168(278)212-112(26-17-18-60-178)171(281)228-66-24-32-127(228)166(276)209-109(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-31-126(227)165(275)197-80-132(240)203-107(51-56-133(241)242)150(260)223-123(78-137(249)250)156(266)200-90(12)143(253)225-125(82-231)172(282)229-67-25-33-128(229)167(277)210-111(54-59-136(247)248)152(262)208-110(53-58-135(245)246)153(263)214-115(69-85(4)5)158(268)222-122(77-131(181)239)163(273)206-104(28-20-62-194-175(186)187)148(258)217-118(73-96-38-46-101(235)47-39-96)161(271)218-117(72-95-36-44-100(234)45-37-95)154(264)199-89(11)142(252)224-124(81-230)164(274)216-114(68-84(2)3)157(267)205-105(29-21-63-195-176(188)189)149(259)220-120(75-98-79-192-83-198-98)162(272)219-119(74-97-40-48-102(236)49-41-97)160(270)215-116(70-86(6)7)159(269)221-121(76-130(180)238)155(265)201-91(13)144(254)226-139(87(8)9)173(283)284-140(93(15)232)169(279)211-106(30-22-64-196-177(190)191)146(256)207-108(50-55-129(179)237)151(261)204-103(27-19-61-193-174(184)185)147(257)213-113(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,275)(H,199,264)(H,200,266)(H,201,265)(H,202,255)(H,203,240)(H,204,261)(H,205,267)(H,206,273)(H,207,256)(H,208,262)(H,209,276)(H,210,277)(H,211,279)(H,212,278)(H,213,257)(H,214,263)(H,215,270)(H,216,274)(H,217,258)(H,218,271)(H,219,272)(H,220,259)(H,221,269)(H,222,268)(H,223,260)(H,224,252)(H,225,253)(H,226,254)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>500n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444590
PNG
(CHEMBL3099727)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)168(278)211-111(26-17-18-60-178)171(281)228-66-24-31-126(228)165(275)208-108(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-30-125(227)164(274)197-80-132(240)203-106(51-56-133(241)242)149(259)222-122(78-137(249)250)155(265)200-90(12)143(253)224-124(82-231)172(282)229-67-25-32-127(229)166(276)209-110(54-59-136(247)248)151(261)207-109(53-58-135(245)246)152(262)213-114(69-85(4)5)157(267)221-121(77-131(181)239)162(272)206-104(28-20-62-194-175(186)187)147(257)216-117(73-96-38-46-101(235)47-39-96)160(270)217-116(72-95-36-44-100(234)45-37-95)153(263)199-89(11)142(252)223-123(81-230)163(273)215-113(68-84(2)3)156(266)205-105(29-21-63-195-176(188)189)148(258)219-119(75-98-79-192-83-198-98)161(271)218-118(74-97-40-48-102(236)49-41-97)159(269)214-115(70-86(6)7)158(268)220-120(76-130(180)238)154(264)201-91(13)144(254)225-139(87(8)9)169(279)226-140(93(15)232)173(283)284-128(33-22-64-196-177(190)191)167(277)210-107(50-55-129(179)237)150(260)204-103(27-19-61-193-174(184)185)146(256)212-112(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,274)(H,199,263)(H,200,265)(H,201,264)(H,202,255)(H,203,240)(H,204,260)(H,205,266)(H,206,272)(H,207,261)(H,208,275)(H,209,276)(H,210,277)(H,211,278)(H,212,256)(H,213,262)(H,214,269)(H,215,273)(H,216,257)(H,217,270)(H,218,271)(H,219,258)(H,220,268)(H,221,267)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,279)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>500n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50444586
PNG
(CHEMBL3099725)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)O[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)212-112(26-17-18-60-178)171(281)228-66-24-32-127(228)165(275)209-109(52-57-134(243)244)144(254)201-91(13)170(280)227-65-23-31-126(227)164(274)197-80-132(240)203-107(51-56-133(241)242)149(259)223-123(78-137(249)250)155(265)200-90(12)143(253)225-125(82-231)172(282)229-67-25-33-128(229)166(276)210-111(54-59-136(247)248)151(261)208-110(53-58-135(245)246)152(262)214-115(69-85(4)5)157(267)222-122(77-131(181)239)162(272)206-104(28-20-62-194-175(186)187)147(257)217-118(73-96-38-46-101(235)47-39-96)160(270)218-117(72-95-36-44-100(234)45-37-95)153(263)199-89(11)142(252)224-124(81-230)163(273)216-114(68-84(2)3)156(266)205-105(29-21-63-195-176(188)189)148(258)220-120(75-98-79-192-83-198-98)161(271)219-119(74-97-40-48-102(236)49-41-97)159(269)215-116(70-86(6)7)158(268)221-121(76-130(180)238)154(264)202-92(14)173(283)284-140(87(8)9)169(279)226-139(93(15)232)168(278)211-106(30-22-64-196-177(190)191)145(255)207-108(50-55-129(179)237)150(260)204-103(27-19-61-193-174(184)185)146(256)213-113(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,274)(H,199,263)(H,200,265)(H,201,254)(H,202,264)(H,203,240)(H,204,260)(H,205,266)(H,206,272)(H,207,255)(H,208,261)(H,209,275)(H,210,276)(H,211,278)(H,212,277)(H,213,256)(H,214,262)(H,215,269)(H,216,273)(H,217,257)(H,218,270)(H,219,271)(H,220,258)(H,221,268)(H,222,267)(H,223,259)(H,224,252)(H,225,253)(H,226,279)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>500n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


ACS Med Chem Lett 4: 1228-32 (2013)


Article DOI: 10.1021/ml400335g
BindingDB Entry DOI: 10.7270/Q28S4RD1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466553
PNG
(CHEMBL4279794)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 790n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466553
PNG
(CHEMBL4279794)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 794n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466563
PNG
(CHEMBL4294418)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C104H164N32O25/c1-8-57(6)84-99(158)127-67(19-11-13-41-105)87(146)117-43-14-9-10-24-82(144)122-68(21-16-44-118-102(109)110)88(147)131-76(51-62-53-115-54-121-62)96(155)130-75(49-60-27-33-64(139)34-28-60)95(154)129-74(47-55(2)3)94(153)132-77(52-80(108)142)97(156)125-69(20-12-15-42-116-81(143)40-38-73(93(152)135-84)123-86(145)66(106)48-59-25-31-63(138)32-26-59)92(151)134-83(56(4)5)98(157)136-85(58(7)137)100(159)128-71(23-18-46-120-104(113)114)89(148)126-72(37-39-79(107)141)91(150)124-70(22-17-45-119-103(111)112)90(149)133-78(101(160)161)50-61-29-35-65(140)36-30-61/h25-36,53-58,66-78,83-85,137-140H,8-24,37-52,105-106H2,1-7H3,(H2,107,141)(H2,108,142)(H,115,121)(H,116,143)(H,117,146)(H,122,144)(H,123,145)(H,124,150)(H,125,156)(H,126,148)(H,127,158)(H,128,159)(H,129,154)(H,130,155)(H,131,147)(H,132,153)(H,133,149)(H,134,151)(H,135,152)(H,136,157)(H,160,161)(H4,109,110,118)(H4,111,112,119)(H4,113,114,120)/t57-,58+,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-,85-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466549
PNG
(CHEMBL4282168)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccccc1N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C79H120N26O19/c1-39(2)31-54(98-70(117)56(33-43-18-22-46(107)23-19-43)100-71(118)57(35-45-37-89-38-93-45)101-66(113)50(15-10-28-90-77(83)84)94-64(111)48-13-8-9-14-49(48)80)69(116)102-58(36-61(82)110)72(119)99-55(32-40(3)4)73(120)104-62(41(5)6)74(121)105-63(42(7)106)75(122)97-52(17-12-30-92-79(87)88)65(112)96-53(26-27-60(81)109)68(115)95-51(16-11-29-91-78(85)86)67(114)103-59(76(123)124)34-44-20-24-47(108)25-21-44/h8-9,13-14,18-25,37-42,50-59,62-63,106-108H,10-12,15-17,26-36,80H2,1-7H3,(H2,81,109)(H2,82,110)(H,89,93)(H,94,111)(H,95,115)(H,96,112)(H,97,122)(H,98,117)(H,99,119)(H,100,118)(H,101,113)(H,102,116)(H,103,114)(H,104,120)(H,105,121)(H,123,124)(H4,83,84,90)(H4,85,86,91)(H4,87,88,92)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466529
PNG
(CHEMBL4283257)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C186H279N53O55/c1-15-94(10)148(191)176(287)221-120(30-18-19-63-187)180(291)238-69-25-35-136(238)174(285)218-117(55-60-144(254)255)153(264)210-97(13)179(290)237-68-24-34-135(237)173(284)206-86-142(251)212-115(54-59-143(252)253)158(269)232-131(83-147(260)261)162(273)209-96(12)152(263)234-134(88-241)181(292)239-70-26-36-137(239)175(286)219-119(57-62-146(258)259)159(270)217-118(56-61-145(256)257)160(271)222-122(72-91(4)5)164(275)230-129(81-139(189)248)169(280)215-112(31-21-65-202-184(194)195)156(267)225-125(75-100-39-47-107(244)48-40-100)167(278)226-124(74-99-37-45-106(243)46-38-99)161(272)208-95(11)151(262)233-133(87-240)172(283)224-121(71-90(2)3)163(274)214-113(32-22-66-203-185(196)197)157(268)229-128(79-105-85-200-89-207-105)168(279)227-126(76-101-41-49-108(245)50-42-101)166(277)223-123(73-92(6)7)165(276)231-130(82-140(190)249)170(281)228-127(78-103-84-205-111-29-17-16-28-110(103)111)171(282)235-149(93(8)9)177(288)236-150(98(14)242)178(289)220-114(33-23-67-204-186(198)199)155(266)216-116(53-58-138(188)247)154(265)211-104(27-20-64-201-183(192)193)80-141(250)213-132(182(293)294)77-102-43-51-109(246)52-44-102/h16-17,28-29,37-52,84-85,89-98,104,112-137,148-150,205,240-246H,15,18-27,30-36,53-83,86-88,187,191H2,1-14H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,284)(H,208,272)(H,209,273)(H,210,264)(H,211,265)(H,212,251)(H,213,250)(H,214,274)(H,215,280)(H,216,266)(H,217,270)(H,218,285)(H,219,286)(H,220,289)(H,221,287)(H,222,271)(H,223,277)(H,224,283)(H,225,267)(H,226,278)(H,227,279)(H,228,281)(H,229,268)(H,230,275)(H,231,276)(H,232,269)(H,233,262)(H,234,263)(H,235,282)(H,236,288)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,104-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,148-,149-,150-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466542
PNG
(CHEMBL4290445)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466525
PNG
(CHEMBL4285633)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCNC(N)=N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C180H278N52O55/c1-17-91(12)142(185)170(280)214-114(26-18-19-60-181)174(284)231-66-24-31-130(231)168(278)211-111(51-56-138(247)248)147(257)203-94(15)173(283)230-65-23-30-129(230)167(277)199-82-136(244)205-109(50-55-137(245)246)152(262)225-125(80-141(253)254)156(266)202-93(14)146(256)227-128(84-234)175(285)232-67-25-32-131(232)169(279)212-113(53-58-140(251)252)153(263)210-112(52-57-139(249)250)154(264)215-116(69-87(4)5)158(268)223-123(78-133(183)241)163(273)208-106(27-20-61-195-177(186)187)150(260)219-120(73-97-35-43-103(237)44-36-97)161(271)220-119(72-96-33-41-102(236)42-34-96)155(265)201-92(13)145(255)226-127(83-233)166(276)218-115(68-86(2)3)157(267)207-107(28-21-62-196-178(188)189)151(261)222-122(76-101-81-194-85-200-101)162(272)221-121(74-98-37-45-104(238)46-38-98)160(270)216-117(70-88(6)7)159(269)224-124(79-134(184)242)164(274)217-118(71-89(8)9)165(275)228-143(90(10)11)171(281)229-144(95(16)235)172(282)213-108(29-22-63-197-179(190)191)149(259)209-110(49-54-132(182)240)148(258)204-100(59-64-198-180(192)193)77-135(243)206-126(176(286)287)75-99-39-47-105(239)48-40-99/h33-48,81,85-95,100,106-131,142-144,233-239H,17-32,49-80,82-84,181,185H2,1-16H3,(H2,182,240)(H2,183,241)(H2,184,242)(H,194,200)(H,199,277)(H,201,265)(H,202,266)(H,203,257)(H,204,258)(H,205,244)(H,206,243)(H,207,267)(H,208,273)(H,209,259)(H,210,263)(H,211,278)(H,212,279)(H,213,282)(H,214,280)(H,215,264)(H,216,270)(H,217,274)(H,218,276)(H,219,260)(H,220,271)(H,221,272)(H,222,261)(H,223,268)(H,224,269)(H,225,262)(H,226,255)(H,227,256)(H,228,275)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,286,287)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)(H4,192,193,198)/t91-,92-,93-,94-,95+,100-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466534
PNG
(CHEMBL4288294)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-18-92(12)142(186)170(280)214-115(28-19-20-62-182)175(285)232-68-26-34-130(232)168(278)210-111(54-59-138(247)248)147(257)204-95(15)173(283)231-67-25-33-129(231)167(277)200-83-136(244)205-109(53-58-137(245)246)151(261)225-126(81-141(253)254)156(266)203-94(14)146(256)227-128(85-235)176(286)233-69-27-35-131(233)169(279)211-113(56-61-140(251)252)152(262)209-112(55-60-139(249)250)154(264)215-117(71-88(4)5)158(268)223-124(79-134(184)242)163(273)207-106(29-21-63-196-178(187)188)149(259)219-121(75-98-38-46-103(238)47-39-98)161(271)220-120(74-97-36-44-102(237)45-37-97)155(265)202-93(13)145(255)226-127(84-234)166(276)218-116(70-87(2)3)157(267)206-107(30-22-64-197-179(189)190)150(260)222-123(78-101-82-195-86-201-101)162(272)221-122(76-99-40-48-104(239)49-41-99)160(270)216-118(72-89(6)7)159(269)224-125(80-135(185)243)164(274)217-119(73-90(8)9)165(275)228-143(91(10)11)171(281)229-144(96(16)236)172(282)212-108(31-23-65-198-180(191)192)148(258)208-110(52-57-133(183)241)153(263)213-114(32-24-66-199-181(193)194)174(284)230(17)132(177(287)288)77-100-42-50-105(240)51-43-100/h36-51,82,86-96,106-132,142-144,234-240H,18-35,52-81,83-85,182,186H2,1-17H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,277)(H,202,265)(H,203,266)(H,204,257)(H,205,244)(H,206,267)(H,207,273)(H,208,258)(H,209,262)(H,210,278)(H,211,279)(H,212,282)(H,213,263)(H,214,280)(H,215,264)(H,216,270)(H,217,274)(H,218,276)(H,219,259)(H,220,271)(H,221,272)(H,222,260)(H,223,268)(H,224,269)(H,225,261)(H,226,255)(H,227,256)(H,228,275)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466534
PNG
(CHEMBL4288294)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-18-92(12)142(186)170(280)214-115(28-19-20-62-182)175(285)232-68-26-34-130(232)168(278)210-111(54-59-138(247)248)147(257)204-95(15)173(283)231-67-25-33-129(231)167(277)200-83-136(244)205-109(53-58-137(245)246)151(261)225-126(81-141(253)254)156(266)203-94(14)146(256)227-128(85-235)176(286)233-69-27-35-131(233)169(279)211-113(56-61-140(251)252)152(262)209-112(55-60-139(249)250)154(264)215-117(71-88(4)5)158(268)223-124(79-134(184)242)163(273)207-106(29-21-63-196-178(187)188)149(259)219-121(75-98-38-46-103(238)47-39-98)161(271)220-120(74-97-36-44-102(237)45-37-97)155(265)202-93(13)145(255)226-127(84-234)166(276)218-116(70-87(2)3)157(267)206-107(30-22-64-197-179(189)190)150(260)222-123(78-101-82-195-86-201-101)162(272)221-122(76-99-40-48-104(239)49-41-99)160(270)216-118(72-89(6)7)159(269)224-125(80-135(185)243)164(274)217-119(73-90(8)9)165(275)228-143(91(10)11)171(281)229-144(96(16)236)172(282)212-108(31-23-65-198-180(191)192)148(258)208-110(52-57-133(183)241)153(263)213-114(32-24-66-199-181(193)194)174(284)230(17)132(177(287)288)77-100-42-50-105(240)51-43-100/h36-51,82,86-96,106-132,142-144,234-240H,18-35,52-81,83-85,182,186H2,1-17H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,277)(H,202,265)(H,203,266)(H,204,257)(H,205,244)(H,206,267)(H,207,273)(H,208,258)(H,209,262)(H,210,278)(H,211,279)(H,212,282)(H,213,263)(H,214,280)(H,215,264)(H,216,270)(H,217,274)(H,218,276)(H,219,259)(H,220,271)(H,221,272)(H,222,260)(H,223,268)(H,224,269)(H,225,261)(H,226,255)(H,227,256)(H,228,275)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466540
PNG
(CHEMBL4287058)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-17-92(12)143(186)171(281)215-115(28-18-19-61-182)175(285)232-67-25-33-131(232)169(279)212-112(53-58-139(248)249)148(258)204-95(15)174(284)231-66-24-32-130(231)168(278)200-83-137(245)206-110(52-57-138(246)247)153(263)226-126(81-142(254)255)157(267)203-94(14)147(257)228-129(85-235)176(286)233-68-26-34-132(233)170(280)213-114(55-60-141(252)253)154(264)211-113(54-59-140(250)251)155(265)216-117(70-88(4)5)159(269)224-124(79-134(184)242)164(274)209-107(29-21-63-197-179(189)190)151(261)220-121(74-98-37-45-104(238)46-38-98)162(272)221-120(73-97-35-43-103(237)44-36-97)156(266)202-93(13)146(256)227-128(84-234)167(277)219-116(69-87(2)3)158(268)208-108(30-22-64-198-180(191)192)152(262)223-123(77-102-82-195-86-201-102)163(273)222-122(75-99-39-47-105(239)48-40-99)161(271)217-118(71-89(6)7)160(270)225-125(80-135(185)243)165(275)218-119(72-90(8)9)166(276)229-144(91(10)11)172(282)230-145(96(16)236)173(283)214-109(31-23-65-199-181(193)194)150(260)210-111(51-56-133(183)241)149(259)205-101(27-20-62-196-178(187)188)78-136(244)207-127(177(287)288)76-100-41-49-106(240)50-42-100/h35-50,82,86-96,101,107-132,143-145,234-240H,17-34,51-81,83-85,182,186H2,1-16H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,278)(H,202,266)(H,203,267)(H,204,258)(H,205,259)(H,206,245)(H,207,244)(H,208,268)(H,209,274)(H,210,260)(H,211,264)(H,212,279)(H,213,280)(H,214,283)(H,215,281)(H,216,265)(H,217,271)(H,218,275)(H,219,277)(H,220,261)(H,221,272)(H,222,273)(H,223,262)(H,224,269)(H,225,270)(H,226,263)(H,227,256)(H,228,257)(H,229,276)(H,230,282)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,101-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466549
PNG
(CHEMBL4282168)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccccc1N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C79H120N26O19/c1-39(2)31-54(98-70(117)56(33-43-18-22-46(107)23-19-43)100-71(118)57(35-45-37-89-38-93-45)101-66(113)50(15-10-28-90-77(83)84)94-64(111)48-13-8-9-14-49(48)80)69(116)102-58(36-61(82)110)72(119)99-55(32-40(3)4)73(120)104-62(41(5)6)74(121)105-63(42(7)106)75(122)97-52(17-12-30-92-79(87)88)65(112)96-53(26-27-60(81)109)68(115)95-51(16-11-29-91-78(85)86)67(114)103-59(76(123)124)34-44-20-24-47(108)25-21-44/h8-9,13-14,18-25,37-42,50-59,62-63,106-108H,10-12,15-17,26-36,80H2,1-7H3,(H2,81,109)(H2,82,110)(H,89,93)(H,94,111)(H,95,115)(H,96,112)(H,97,122)(H,98,117)(H,99,119)(H,100,118)(H,101,113)(H,102,116)(H,103,114)(H,104,120)(H,105,121)(H,123,124)(H4,83,84,90)(H4,85,86,91)(H4,87,88,92)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466542
PNG
(CHEMBL4290445)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466529
PNG
(CHEMBL4283257)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C186H279N53O55/c1-15-94(10)148(191)176(287)221-120(30-18-19-63-187)180(291)238-69-25-35-136(238)174(285)218-117(55-60-144(254)255)153(264)210-97(13)179(290)237-68-24-34-135(237)173(284)206-86-142(251)212-115(54-59-143(252)253)158(269)232-131(83-147(260)261)162(273)209-96(12)152(263)234-134(88-241)181(292)239-70-26-36-137(239)175(286)219-119(57-62-146(258)259)159(270)217-118(56-61-145(256)257)160(271)222-122(72-91(4)5)164(275)230-129(81-139(189)248)169(280)215-112(31-21-65-202-184(194)195)156(267)225-125(75-100-39-47-107(244)48-40-100)167(278)226-124(74-99-37-45-106(243)46-38-99)161(272)208-95(11)151(262)233-133(87-240)172(283)224-121(71-90(2)3)163(274)214-113(32-22-66-203-185(196)197)157(268)229-128(79-105-85-200-89-207-105)168(279)227-126(76-101-41-49-108(245)50-42-101)166(277)223-123(73-92(6)7)165(276)231-130(82-140(190)249)170(281)228-127(78-103-84-205-111-29-17-16-28-110(103)111)171(282)235-149(93(8)9)177(288)236-150(98(14)242)178(289)220-114(33-23-67-204-186(198)199)155(266)216-116(53-58-138(188)247)154(265)211-104(27-20-64-201-183(192)193)80-141(250)213-132(182(293)294)77-102-43-51-109(246)52-44-102/h16-17,28-29,37-52,84-85,89-98,104,112-137,148-150,205,240-246H,15,18-27,30-36,53-83,86-88,187,191H2,1-14H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,284)(H,208,272)(H,209,273)(H,210,264)(H,211,265)(H,212,251)(H,213,250)(H,214,274)(H,215,280)(H,216,266)(H,217,270)(H,218,285)(H,219,286)(H,220,289)(H,221,287)(H,222,271)(H,223,277)(H,224,283)(H,225,267)(H,226,278)(H,227,279)(H,228,281)(H,229,268)(H,230,275)(H,231,276)(H,232,269)(H,233,262)(H,234,263)(H,235,282)(H,236,288)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,104-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,148-,149-,150-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466525
PNG
(CHEMBL4285633)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCNC(N)=N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C180H278N52O55/c1-17-91(12)142(185)170(280)214-114(26-18-19-60-181)174(284)231-66-24-31-130(231)168(278)211-111(51-56-138(247)248)147(257)203-94(15)173(283)230-65-23-30-129(230)167(277)199-82-136(244)205-109(50-55-137(245)246)152(262)225-125(80-141(253)254)156(266)202-93(14)146(256)227-128(84-234)175(285)232-67-25-32-131(232)169(279)212-113(53-58-140(251)252)153(263)210-112(52-57-139(249)250)154(264)215-116(69-87(4)5)158(268)223-123(78-133(183)241)163(273)208-106(27-20-61-195-177(186)187)150(260)219-120(73-97-35-43-103(237)44-36-97)161(271)220-119(72-96-33-41-102(236)42-34-96)155(265)201-92(13)145(255)226-127(83-233)166(276)218-115(68-86(2)3)157(267)207-107(28-21-62-196-178(188)189)151(261)222-122(76-101-81-194-85-200-101)162(272)221-121(74-98-37-45-104(238)46-38-98)160(270)216-117(70-88(6)7)159(269)224-124(79-134(184)242)164(274)217-118(71-89(8)9)165(275)228-143(90(10)11)171(281)229-144(95(16)235)172(282)213-108(29-22-63-197-179(190)191)149(259)209-110(49-54-132(182)240)148(258)204-100(59-64-198-180(192)193)77-135(243)206-126(176(286)287)75-99-39-47-105(239)48-40-99/h33-48,81,85-95,100,106-131,142-144,233-239H,17-32,49-80,82-84,181,185H2,1-16H3,(H2,182,240)(H2,183,241)(H2,184,242)(H,194,200)(H,199,277)(H,201,265)(H,202,266)(H,203,257)(H,204,258)(H,205,244)(H,206,243)(H,207,267)(H,208,273)(H,209,259)(H,210,263)(H,211,278)(H,212,279)(H,213,282)(H,214,280)(H,215,264)(H,216,270)(H,217,274)(H,218,276)(H,219,260)(H,220,271)(H,221,272)(H,222,261)(H,223,268)(H,224,269)(H,225,262)(H,226,255)(H,227,256)(H,228,275)(H,229,281)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,286,287)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)(H4,192,193,198)/t91-,92-,93-,94-,95+,100-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,142-,143-,144-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466540
PNG
(CHEMBL4287058)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C181H280N52O55/c1-17-92(12)143(186)171(281)215-115(28-18-19-61-182)175(285)232-67-25-33-131(232)169(279)212-112(53-58-139(248)249)148(258)204-95(15)174(284)231-66-24-32-130(231)168(278)200-83-137(245)206-110(52-57-138(246)247)153(263)226-126(81-142(254)255)157(267)203-94(14)147(257)228-129(85-235)176(286)233-68-26-34-132(233)170(280)213-114(55-60-141(252)253)154(264)211-113(54-59-140(250)251)155(265)216-117(70-88(4)5)159(269)224-124(79-134(184)242)164(274)209-107(29-21-63-197-179(189)190)151(261)220-121(74-98-37-45-104(238)46-38-98)162(272)221-120(73-97-35-43-103(237)44-36-97)156(266)202-93(13)146(256)227-128(84-234)167(277)219-116(69-87(2)3)158(268)208-108(30-22-64-198-180(191)192)152(262)223-123(77-102-82-195-86-201-102)163(273)222-122(75-99-39-47-105(239)48-40-99)161(271)217-118(71-89(6)7)160(270)225-125(80-135(185)243)165(275)218-119(72-90(8)9)166(276)229-144(91(10)11)172(282)230-145(96(16)236)173(283)214-109(31-23-65-199-181(193)194)150(260)210-111(51-56-133(183)241)149(259)205-101(27-20-62-196-178(187)188)78-136(244)207-127(177(287)288)76-100-41-49-106(240)50-42-100/h35-50,82,86-96,101,107-132,143-145,234-240H,17-34,51-81,83-85,182,186H2,1-16H3,(H2,183,241)(H2,184,242)(H2,185,243)(H,195,201)(H,200,278)(H,202,266)(H,203,267)(H,204,258)(H,205,259)(H,206,245)(H,207,244)(H,208,268)(H,209,274)(H,210,260)(H,211,264)(H,212,279)(H,213,280)(H,214,283)(H,215,281)(H,216,265)(H,217,271)(H,218,275)(H,219,277)(H,220,261)(H,221,272)(H,222,273)(H,223,262)(H,224,269)(H,225,270)(H,226,263)(H,227,256)(H,228,257)(H,229,276)(H,230,282)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,287,288)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t92-,93-,94-,95-,96+,101-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466563
PNG
(CHEMBL4294418)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C104H164N32O25/c1-8-57(6)84-99(158)127-67(19-11-13-41-105)87(146)117-43-14-9-10-24-82(144)122-68(21-16-44-118-102(109)110)88(147)131-76(51-62-53-115-54-121-62)96(155)130-75(49-60-27-33-64(139)34-28-60)95(154)129-74(47-55(2)3)94(153)132-77(52-80(108)142)97(156)125-69(20-12-15-42-116-81(143)40-38-73(93(152)135-84)123-86(145)66(106)48-59-25-31-63(138)32-26-59)92(151)134-83(56(4)5)98(157)136-85(58(7)137)100(159)128-71(23-18-46-120-104(113)114)89(148)126-72(37-39-79(107)141)91(150)124-70(22-17-45-119-103(111)112)90(149)133-78(101(160)161)50-61-29-35-65(140)36-30-61/h25-36,53-58,66-78,83-85,137-140H,8-24,37-52,105-106H2,1-7H3,(H2,107,141)(H2,108,142)(H,115,121)(H,116,143)(H,117,146)(H,122,144)(H,123,145)(H,124,150)(H,125,156)(H,126,148)(H,127,158)(H,128,159)(H,129,154)(H,130,155)(H,131,147)(H,132,153)(H,133,149)(H,134,151)(H,135,152)(H,136,157)(H,160,161)(H4,109,110,118)(H4,111,112,119)(H4,113,114,120)/t57-,58+,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-,85-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50466530
PNG
(CHEMBL4281010)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCCCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C102H160N32O26/c1-6-54(3)81-96(156)129-74(50-78(106)141)93(153)124-67(91(151)132-82(55(4)7-2)97(157)134-83(56(5)136)98(158)126-69(22-17-45-118-102(111)112)87(147)125-70(36-38-77(105)140)89(149)123-68(21-16-44-117-101(109)110)88(148)130-75(99(159)160)48-59-28-34-63(139)35-29-59)19-11-14-41-114-79(142)39-37-71(121-84(144)64(104)46-57-24-30-61(137)31-25-57)90(150)131-76(52-135)95(155)122-65(18-10-12-40-103)85(145)115-42-13-8-9-23-80(143)120-66(20-15-43-116-100(107)108)86(146)128-73(49-60-51-113-53-119-60)92(152)127-72(94(154)133-81)47-58-26-32-62(138)33-27-58/h24-35,51,53-56,64-76,81-83,135-139H,6-23,36-50,52,103-104H2,1-5H3,(H2,105,140)(H2,106,141)(H,113,119)(H,114,142)(H,115,145)(H,120,143)(H,121,144)(H,122,155)(H,123,149)(H,124,153)(H,125,147)(H,126,158)(H,127,152)(H,128,146)(H,129,156)(H,130,148)(H,131,150)(H,132,151)(H,133,154)(H,134,157)(H,159,160)(H4,107,108,116)(H4,109,110,117)(H4,111,112,118)/t54-,55-,56+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,81-,82-,83-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a<1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...


J Med Chem 61: 10519-10530 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1583 total )  |  Next  |  Last  >>
Jump to: