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Compile Data Set for Download or QSAR

Found 2492 hits Enz. Inhib. hit(s) with Target = 'Neurotrophic tyrosine kinase receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50446394
PNG
(CHEMBL3109646 | US9181261, 1)
Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C19H19F3N4OS/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)
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n/an/an/an/a 6.5n/an/an/an/a


TBA

Assay Description
Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs


Citation and Details

Article DOI: 10.1021/ml4005073
BindingDB Entry DOI: 10.7270/Q2B56M6V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50446394
PNG
(CHEMBL3109646 | US9181261, 1)
Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C19H19F3N4OS/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)
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n/an/an/an/a 6.5n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50446392
PNG
(CHEMBL3109645 | US9181261, 2)
Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H19F3N4O2/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)
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n/an/an/an/a 11n/an/an/an/a


TBA

Assay Description
Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs


Citation and Details

Article DOI: 10.1021/ml4005073
BindingDB Entry DOI: 10.7270/Q2B56M6V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50446392
PNG
(CHEMBL3109645 | US9181261, 2)
Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H19F3N4O2/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)
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n/an/an/an/a 11.3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM191135
PNG
(US9181261, 5)
Show SMILES CC1(C)CCN(C(=O)N1Cc1c[nH]c2ncccc12)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C21H21F3N4OS/c1-20(2)9-11-27(15-5-7-16(8-6-15)30-21(22,23)24)19(29)28(20)13-14-12-26-18-17(14)4-3-10-25-18/h3-8,10,12H,9,11,13H2,1-2H3,(H,25,26)
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n/an/an/an/a 19.7n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM191136
PNG
(US9181261, 6)
Show SMILES CC(C)N(Cc1n[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H18F3N5OS/c1-11(2)26(10-15-14-4-3-9-22-16(14)25-24-15)17(27)23-12-5-7-13(8-6-12)28-18(19,20)21/h3-9,11H,10H2,1-2H3,(H,23,27)(H,22,24,25)
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n/an/an/an/a 24.9n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 30n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of TrkC by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM191137
PNG
(US9181261, 10)
Show SMILES CC(C#C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H18F3N3O2S/c1-3-15(2)28(14-16-5-4-6-17(13-16)20-26-11-12-31-20)21(29)27-18-7-9-19(10-8-18)30-22(23,24)25/h1,4-13,15H,14H2,2H3,(H,27,29)
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n/an/an/an/a 48n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50073587
PNG
(CHEMBL3408947)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
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n/an/an/an/a 84n/an/an/an/a



Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of TRKA (unknown origin)


Eur J Med Chem 95: 35-40 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.020
BindingDB Entry DOI: 10.7270/Q2NG4SBV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50073587
PNG
(CHEMBL3408947)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
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n/an/an/an/a 84n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TRKA (unknown origin) by cell-based assay


J Med Chem 58: 147-69 (2015)


Article DOI: 10.1021/jm5005336
BindingDB Entry DOI: 10.7270/Q2M0475V
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50073587
PNG
(CHEMBL3408947)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
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n/an/an/an/a 88n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin) by cell-based assay


J Med Chem 58: 147-69 (2015)


Article DOI: 10.1021/jm5005336
BindingDB Entry DOI: 10.7270/Q2M0475V
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50073587
PNG
(CHEMBL3408947)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
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n/an/an/an/a 88n/an/an/an/a



Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin)


Eur J Med Chem 95: 35-40 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.020
BindingDB Entry DOI: 10.7270/Q2NG4SBV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM191138
PNG
(US9181261, 15)
Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1cnc(nc1)C(C)(C)C
Show InChI InChI=1S/C22H27N5OS/c1-15(2)27(14-16-7-6-8-17(11-16)19-23-9-10-29-19)21(28)26-18-12-24-20(25-13-18)22(3,4)5/h6-13,15H,14H2,1-5H3,(H,26,28)
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n/an/an/an/a 102n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50022677
PNG
(CHEMBL3298270 | US9181261, 17)
Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H20F3N3O2S/c1-14(2)27(13-15-4-3-5-16(12-15)19-25-10-11-30-19)20(28)26-17-6-8-18(9-7-17)29-21(22,23)24/h3-12,14H,13H2,1-2H3,(H,26,28)
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n/an/an/an/a 119n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM191139
PNG
(US9181261, 20)
Show SMILES CC(C)N(Cc1n[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H18F3N5O2/c1-11(2)26(10-15-14-4-3-9-22-16(14)25-24-15)17(27)23-12-5-7-13(8-6-12)28-18(19,20)21/h3-9,11H,10H2,1-2H3,(H,23,27)(H,22,24,25)
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n/an/an/an/a 141n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of TrkC by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50446393
PNG
(CHEMBL3109644 | US9181261, 74)
Show SMILES CC1(C)CN(C(=O)N1Cc1cccc(c1)-c1nccs1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H20F3N3O2S/c1-21(2)14-27(17-6-8-18(9-7-17)30-22(23,24)25)20(29)28(21)13-15-4-3-5-16(12-15)19-26-10-11-31-19/h3-12H,13-14H2,1-2H3
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n/an/an/an/a 1.01E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50446393
PNG
(CHEMBL3109644 | US9181261, 74)
Show SMILES CC1(C)CN(C(=O)N1Cc1cccc(c1)-c1nccs1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H20F3N3O2S/c1-21(2)14-27(17-6-8-18(9-7-17)30-22(23,24)25)20(29)28(21)13-15-4-3-5-16(12-15)19-26-10-11-31-19/h3-12H,13-14H2,1-2H3
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n/an/an/an/a 1.01E+3n/an/an/an/a


TBA

Assay Description
Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs


Citation and Details

Article DOI: 10.1021/ml4005073
BindingDB Entry DOI: 10.7270/Q2B56M6V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a>2.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of NTRK1


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM191140
PNG
(US9181261, 152)
Show SMILES CC(C)N(Cc1cc(ccn1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H19F3N4O2S/c1-13(2)27(12-16-11-14(7-8-24-16)18-25-9-10-30-18)19(28)26-15-3-5-17(6-4-15)29-20(21,22)23/h3-11,13H,12H2,1-2H3,(H,26,28)
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n/an/an/an/a 8.08E+3n/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...


US Patent US9181261 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PJ5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Rattus norvegicus)
BDBM50111443
PNG
(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Show SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Show InChI InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2
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n/an/an/an/a 2.20E+4n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based method


J Med Chem 60: 66-88 (2017)


Article DOI: 10.1021/acs.jmedchem.6b00964
BindingDB Entry DOI: 10.7270/Q2C24ZCR
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES CN(C)CCC=C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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n/an/an/an/a 8.60E+4n/an/an/an/a



Southmead Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at full length glycosylated human TrkA expressed in HEKN3S cells cells assessed as reduction in NGF-induced ERK 42/44 phosphoryla...


J Med Chem 58: 767-77 (2015)


Article DOI: 10.1021/jm501307e
BindingDB Entry DOI: 10.7270/Q25B045H
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50018839
PNG
(CHEMBL3286829)
Show SMILES C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2CN(C)C(=O)c2ccc(F)cc12)C1CC1
Show InChI InChI=1S/C23H24FN5O2/c1-12-17-9-15(24)6-7-16(17)23(30)28(2)11-18-20(21(13-4-5-13)27-29(18)3)14-8-19(31-12)22(25)26-10-14/h6-10,12-13H,4-5,11H2,1-3H3,(H2,25,26)/t12-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin) by off-chip mobility shift assay


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50018815
PNG
(CHEMBL3286820)
Show SMILES C[C@H]1Oc2cc(cnc2N)-c2c(C)nn(C)c2CN(C)C(=O)c2ccc(F)cc12
Show InChI InChI=1S/C21H22FN5O2/c1-11-19-13-7-18(20(23)24-9-13)29-12(2)16-8-14(22)5-6-15(16)21(28)26(3)10-17(19)27(4)25-11/h5-9,12H,10H2,1-4H3,(H2,23,24)/t12-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin) by off-chip mobility shift assay


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50018830
PNG
(CHEMBL3286830)
Show SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N
Show InChI InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
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23n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin) by off-chip mobility shift assay


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50018842
PNG
(CHEMBL3286832)
Show SMILES C[C@H]1Oc2nc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nc1ccc(cn21)C#N
Show InChI InChI=1S/C23H18FN7O2/c1-12-16-7-14(24)4-5-15(16)23(32)30(2)11-18-20(17-9-27-21(26)22(29-17)33-12)31-10-13(8-25)3-6-19(31)28-18/h3-7,9-10,12H,11H2,1-2H3,(H2,26,27)/t12-/m1/s1
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65n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin) by off-chip mobility shift assay


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50018841
PNG
(CHEMBL3286831)
Show SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nc1ncc(C)cn21
Show InChI InChI=1S/C23H21FN6O2/c1-12-8-27-23-28-18-11-29(3)22(31)16-5-4-15(24)7-17(16)13(2)32-19-6-14(9-26-21(19)25)20(18)30(23)10-12/h4-10,13H,11H2,1-3H3,(H2,25,26)/t13-/m1/s1
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77n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKB (unknown origin) by off-chip mobility shift assay


J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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>2.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant TRKA after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>2.48E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TRKA


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50093352
PNG
(CHEMBL3586678)
Show SMILES COc1cncc(n1)N1CCc2nc(NC(=O)NCCc3cn(CC(F)F)cn3)sc2C1
Show InChI InChI=1S/C19H22F2N8O2S/c1-31-17-7-22-6-16(26-17)29-5-3-13-14(9-29)32-19(25-13)27-18(30)23-4-2-12-8-28(11-24-12)10-15(20)21/h6-8,11,15H,2-5,9-10H2,1H3,(H2,23,25,27,30)
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3.60E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assay


J Med Chem 58: 5684-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00498
BindingDB Entry DOI: 10.7270/Q2Z89F53
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50093351
PNG
(CHEMBL3585362)
Show SMILES COc1cc(cnc1Cl)N1CCc2nc(NC(=O)NCCc3cn(CC(F)F)cn3)sc2C1
Show InChI InChI=1S/C20H22ClF2N7O2S/c1-32-15-6-13(7-25-18(15)21)30-5-3-14-16(9-30)33-20(27-14)28-19(31)24-4-2-12-8-29(11-26-12)10-17(22)23/h6-8,11,17H,2-5,9-10H2,1H3,(H2,24,27,28,31)
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assay


J Med Chem 58: 5684-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00498
BindingDB Entry DOI: 10.7270/Q2Z89F53
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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>4.50E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant TRKB after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>4.54E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TRKB


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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8.24E+3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24898
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(methylcar...)
Show SMILES CNC(=O)Nc1snc(SCc2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C13H13ClN4O2S2/c1-16-13(20)17-11-9(10(15)19)12(18-22-11)21-6-7-2-4-8(14)5-3-7/h2-5H,6H2,1H3,(H2,15,19)(H2,16,17,20)
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n/an/a 7n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24899
PNG
(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-[(methylca...)
Show SMILES CNC(=O)Nc1snc(SC(C)c2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C14H15ClN4O2S2/c1-7(8-3-5-9(15)6-4-8)22-13-10(11(16)20)12(23-19-13)18-14(21)17-2/h3-7H,1-2H3,(H2,16,20)(H2,17,18,21)
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n/an/a 3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24900
PNG
(3-{[1-(4-chlorophenyl)propyl]sulfanyl}-5-[(methylc...)
Show SMILES CCC(Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN4O2S2/c1-3-10(8-4-6-9(16)7-5-8)23-14-11(12(17)21)13(24-20-14)19-15(22)18-2/h4-7,10H,3H2,1-2H3,(H2,17,21)(H2,18,19,22)
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n/an/a 9n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24901
PNG
(3-{[(1R)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(me...)
Show SMILES CC[C@@H](Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN4O2S2/c1-3-10(8-4-6-9(16)7-5-8)23-14-11(12(17)21)13(24-20-14)19-15(22)18-2/h4-7,10H,3H2,1-2H3,(H2,17,21)(H2,18,19,22)/t10-/m1/s1
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n/an/a 4n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24902
PNG
(3-{[(1S)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(me...)
Show SMILES CC[C@H](Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN4O2S2/c1-3-10(8-4-6-9(16)7-5-8)23-14-11(12(17)21)13(24-20-14)19-15(22)18-2/h4-7,10H,3H2,1-2H3,(H2,17,21)(H2,18,19,22)/t10-/m0/s1
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n/an/a 52n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24903
PNG
(3-{[1-(4-chlorophenyl)-2-methylpropyl]sulfanyl}-5-...)
Show SMILES CNC(=O)Nc1snc(SC(C(C)C)c2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C16H19ClN4O2S2/c1-8(2)12(9-4-6-10(17)7-5-9)24-15-11(13(18)22)14(25-21-15)20-16(23)19-3/h4-8,12H,1-3H3,(H2,18,22)(H2,19,20,23)
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n/an/a 16n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24904
PNG
(3-{[1-(4-chlorophenyl)butyl]sulfanyl}-5-[(methylca...)
Show SMILES CCCC(Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H19ClN4O2S2/c1-3-4-11(9-5-7-10(17)8-6-9)24-15-12(13(18)22)14(25-21-15)20-16(23)19-2/h5-8,11H,3-4H2,1-2H3,(H2,18,22)(H2,19,20,23)
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n/an/a 35n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24905
PNG
(3-{[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]sulfan...)
Show SMILES CNC(=O)Nc1snc(SC(c2ccc(Cl)cc2)C(F)(F)F)c1C(N)=O
Show InChI InChI=1S/C14H12ClF3N4O2S2/c1-20-13(24)21-11-8(10(19)23)12(22-26-11)25-9(14(16,17)18)6-2-4-7(15)5-3-6/h2-5,9H,1H3,(H2,19,23)(H2,20,21,24)
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n/an/a 110n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24906
PNG
(3-{[(4-chlorophenyl)(phenyl)methyl]sulfanyl}-5-[(m...)
Show SMILES CNC(=O)Nc1snc(SC(c2ccccc2)c2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C19H17ClN4O2S2/c1-22-19(26)23-17-14(16(21)25)18(24-28-17)27-15(11-5-3-2-4-6-11)12-7-9-13(20)10-8-12/h2-10,15H,1H3,(H2,21,25)(H2,22,23,26)
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n/an/a 2.60E+3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24907
PNG
(1-(3-{[(4-chlorophenyl)methyl]sulfanyl}-4-cyano-1,...)
Show SMILES CNC(=O)Nc1snc(SCc2ccc(Cl)cc2)c1C#N
Show InChI InChI=1S/C13H11ClN4OS2/c1-16-13(19)17-11-10(6-15)12(18-21-11)20-7-8-2-4-9(14)5-3-8/h2-5H,7H2,1H3,(H2,16,17,19)
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n/an/a>5.00E+3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24908
PNG
(5-amino-3-{[(4-chlorophenyl)methyl]sulfanyl}-1,2-t...)
Show SMILES NC(=O)c1c(N)snc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C11H10ClN3OS2/c12-7-3-1-6(2-4-7)5-17-11-8(9(13)16)10(14)18-15-11/h1-4H,5,14H2,(H2,13,16)
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n/an/a>5.00E+3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24909
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-2-...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1ccccn1
Show InChI InChI=1S/C16H13ClN4OS2/c17-11-6-4-10(5-7-11)9-23-16-13(14(18)22)15(24-21-16)20-12-3-1-2-8-19-12/h1-8H,9H2,(H2,18,22)(H,19,20)
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n/an/a 33n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24910
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-3-...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1cccnc1
Show InChI InChI=1S/C16H13ClN4OS2/c17-11-5-3-10(4-6-11)9-23-16-13(14(18)22)15(24-21-16)20-12-2-1-7-19-8-12/h1-8,20H,9H2,(H2,18,22)
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n/an/a 19n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24911
PNG
(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-(pyridin-3...)
Show SMILES CC(Sc1nsc(Nc2cccnc2)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN4OS2/c1-10(11-4-6-12(18)7-5-11)24-17-14(15(19)23)16(25-22-17)21-13-3-2-8-20-9-13/h2-10,21H,1H3,(H2,19,23)
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n/an/a 29n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24912
PNG
(3-[(cyclohexylmethyl)sulfanyl]-5-(pyridin-3-ylamin...)
Show SMILES NC(=O)c1c(SCC2CCCCC2)nsc1Nc1cccnc1
Show InChI InChI=1S/C16H20N4OS2/c17-14(21)13-15(19-12-7-4-8-18-9-12)23-20-16(13)22-10-11-5-2-1-3-6-11/h4,7-9,11,19H,1-3,5-6,10H2,(H2,17,21)
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n/an/a 610n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
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