Compile Data Set for Download or QSAR

Found 3577 hits Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Forma Therapeutics Inc Curated by ChEMBL					Assay Description Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50011266 (CHEMBL3260358) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
Forma Therapeutics Inc Curated by ChEMBL					Assay Description Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Mus musculus)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Forma Therapeutics Inc Curated by ChEMBL					Assay Description Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Mus musculus)	BDBM50011266 (CHEMBL3260358) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Forma Therapeutics Inc Curated by ChEMBL					Assay Description Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81395 (APO-866) Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 Show InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL					Assay Description Noncompetitive inhibition of NAMPT (unknown origin)				J Med Chem 56: 6279-96 (2013) Article DOI: 10.1021/jm4001049 BindingDB Entry DOI: 10.7270/Q25Q4XJ8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217112 (US9302989, 407) Show SMILES O=C(Nc1ccc(cc1)C1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C27H27N3O2/c31-26(22-6-2-1-3-7-22)29-16-14-21(15-17-29)20-10-12-25(13-11-20)28-27(32)30-18-23-8-4-5-9-24(23)19-30/h1-13,21H,14-19H2,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254198 (CHEMBL4060799) Show SMILES CN1CCN(CC1)C(C)(C)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C29H39N5O2/c1-29(2,34-18-16-31(3)17-19-34)27(35)32-14-12-23(13-15-32)22-8-10-26(11-9-22)30-28(36)33-20-24-6-4-5-7-25(24)21-33/h4-11,23H,12-21H2,1-3H3,(H,30,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217057 (US9302989, 349) Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C25H31N3O2/c29-24(21-9-2-1-3-10-21)27-16-13-20(14-17-27)8-6-7-15-26-25(30)28-18-22-11-4-5-12-23(22)19-28/h1-5,9-12,20H,6-8,13-19H2,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254199 (CHEMBL4083505) Show SMILES Clc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C1CCN(CC1)C(=O)[C@@H]1CCCO1 Show InChI InChI=1/C25H28ClN3O3/c26-21-6-3-19-15-29(16-20(19)14-21)25(31)27-22-7-4-17(5-8-22)18-9-11-28(12-10-18)24(30)23-2-1-13-32-23/h3-8,14,18,23H,1-2,9-13,15-16H2,(H,27,31)/t23-/s2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254216 (CHEMBL4096471) Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C1CN(C1)C(=O)c1ccccc1 Show InChI InChI=1S/C25H22FN3O2/c26-22-9-6-19-13-29(14-20(19)12-22)25(31)27-23-10-7-17(8-11-23)21-15-28(16-21)24(30)18-4-2-1-3-5-18/h1-12,21H,13-16H2,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254215 (CHEMBL4089003) Show SMILES CC(C)(O)CC(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 Show InChI InChI=1S/C25H30FN3O3/c1-25(2,32)14-23(30)28-11-9-18(10-12-28)17-4-7-22(8-5-17)27-24(31)29-15-19-3-6-21(26)13-20(19)16-29/h3-8,13,18,32H,9-12,14-16H2,1-2H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81395 (APO-866) Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 Show InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217040 (US9302989, 332) Show SMILES O=C(Nc1ccc(cc1)C1=CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C27H25N3O2/c31-26(22-6-2-1-3-7-22)29-16-14-21(15-17-29)20-10-12-25(13-11-20)28-27(32)30-18-23-8-4-5-9-24(23)19-30/h1-14H,15-19H2,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50435350 (CHEMBL17289) Show SMILES Clc1ccc(OCCCCCCNC(Nc2ccncc2)=NC#N)cc1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254212 (CHEMBL4076064) Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C1CCN(CC1)S(=O)(=O)C1CC1 Show InChI InChI=1S/C23H26FN3O3S/c24-20-4-1-18-14-26(15-19(18)13-20)23(28)25-21-5-2-16(3-6-21)17-9-11-27(12-10-17)31(29,30)22-7-8-22/h1-6,13,17,22H,7-12,14-15H2,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254192 (CHEMBL4105475) Show SMILES CC1(CC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C25H29N3O2/c1-25(12-13-25)23(29)27-14-10-19(11-15-27)18-6-8-22(9-7-18)26-24(30)28-16-20-4-2-3-5-21(20)17-28/h2-9,19H,10-17H2,1H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215830 (US9302989, 25) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(cc3C2)C#N)cc1 Show InChI InChI=1S/C22H24N4O2/c1-15(2)9-10-24-21(27)17-5-7-20(8-6-17)25-22(28)26-13-18-4-3-16(12-23)11-19(18)14-26/h3-8,11,15H,9-10,13-14H2,1-2H3,(H,24,27)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217170 (US9302989, 608) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(CO)cc3C2)cc1 Show InChI InChI=1S/C22H27N3O3/c1-15(2)9-10-23-21(27)17-5-7-20(8-6-17)24-22(28)25-12-18-4-3-16(14-26)11-19(18)13-25/h3-8,11,15,26H,9-10,12-14H2,1-2H3,(H,23,27)(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254214 (CHEMBL4086819) Show SMILES CC1(COC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C25H29N3O3/c1-25(16-31-17-25)23(29)27-12-10-19(11-13-27)18-6-8-22(9-7-18)26-24(30)28-14-20-4-2-3-5-21(20)15-28/h2-9,19H,10-17H2,1H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217078 (US9302989, 370) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)nc1 Show InChI InChI=1S/C20H24N4O2/c1-14(2)9-10-21-19(25)15-7-8-18(22-11-15)23-20(26)24-12-16-5-3-4-6-17(16)13-24/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,21,25)(H,22,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254184 (CHEMBL4082366) Show SMILES CC(C)(O)CC(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C25H31N3O3/c1-25(2,31)15-23(29)27-13-11-19(12-14-27)18-7-9-22(10-8-18)26-24(30)28-16-20-5-3-4-6-21(20)17-28/h3-10,19,31H,11-17H2,1-2H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM216345 (US9302989, 290) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 Show InChI InChI=1S/C20H24N4O2/c1-14(2)7-10-22-19(25)15-3-5-18(6-4-15)23-20(26)24-12-16-8-9-21-11-17(16)13-24/h3-6,8-9,11,14H,7,10,12-13H2,1-2H3,(H,22,25)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215825 (US9302989, 20) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 Show InChI InChI=1S/C21H24FN3O2/c1-14(2)9-10-23-20(26)15-4-7-19(8-5-15)24-21(27)25-12-16-3-6-18(22)11-17(16)13-25/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,23,26)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215806 (US9302989, 1) Show SMILES O=C(Nc1ccc(cc1)C(=O)NCCCc1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C25H25N3O2/c29-24(26-16-6-9-19-7-2-1-3-8-19)20-12-14-23(15-13-20)27-25(30)28-17-21-10-4-5-11-22(21)18-28/h1-5,7-8,10-15H,6,9,16-18H2,(H,26,29)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254197 (CHEMBL4077485) Show SMILES CN1CCC(CC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccc(F)cc3C2)cc1 Show InChI InChI=1S/C27H33FN4O2/c1-30-12-8-21(9-13-30)26(33)31-14-10-20(11-15-31)19-3-6-25(7-4-19)29-27(34)32-17-22-2-5-24(28)16-23(22)18-32/h2-7,16,20-21H,8-15,17-18H2,1H3,(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215841 (US9302989, 36) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C21H25N3O2/c1-15(2)11-12-22-20(25)16-7-9-19(10-8-16)23-21(26)24-13-17-5-3-4-6-18(17)14-24/h3-10,15H,11-14H2,1-2H3,(H,22,25)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215848 (US9302989, 43) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(C)cc3C2)cc1 Show InChI InChI=1S/C22H27N3O2/c1-15(2)10-11-23-21(26)17-6-8-20(9-7-17)24-22(27)25-13-18-5-4-16(3)12-19(18)14-25/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,23,26)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM216082 (US9302989, 420) Show SMILES O=C(Nc1ccc(cc1)C(=O)NCC1CCCOC1)N1Cc2ccccc2C1 Show InChI InChI=1/C22H25N3O3/c26-21(23-12-16-4-3-11-28-15-16)17-7-9-20(10-8-17)24-22(27)25-13-18-5-1-2-6-19(18)14-25/h1-2,5-10,16H,3-4,11-15H2,(H,23,26)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215857 (US9302989, 53) Show SMILES CC(C)(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C22H27N3O2/c1-22(2,3)12-13-23-20(26)16-8-10-19(11-9-16)24-21(27)25-14-17-6-4-5-7-18(17)15-25/h4-11H,12-15H2,1-3H3,(H,23,26)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254187 (CHEMBL4062838) Show SMILES O=C(Nc1ccc(cc1)C(=O)N1CCN(CC1)c1ccccn1)N1Cc2ccccc2C1 Show InChI InChI=1S/C25H25N5O2/c31-24(29-15-13-28(14-16-29)23-7-3-4-12-26-23)19-8-10-22(11-9-19)27-25(32)30-17-20-5-1-2-6-21(20)18-30/h1-12H,13-18H2,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217111 (US9302989, 406) Show SMILES CC(C)C(=O)N1CCC(CC1)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C24H29N3O2/c1-17(2)23(28)26-13-11-19(12-14-26)18-7-9-22(10-8-18)25-24(29)27-15-20-5-3-4-6-21(20)16-27/h3-10,17,19H,11-16H2,1-2H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215863 (US9302989, 59) Show SMILES COc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)C(=O)NCCC(C)C Show InChI InChI=1S/C22H27N3O3/c1-15(2)10-11-23-21(26)16-4-7-19(8-5-16)24-22(27)25-13-17-6-9-20(28-3)12-18(17)14-25/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,23,26)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215871 (US9302989, 67) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3cccc(Cl)c3C2)cc1 Show InChI InChI=1S/C21H24ClN3O2/c1-14(2)10-11-23-20(26)15-6-8-17(9-7-15)24-21(27)25-12-16-4-3-5-19(22)18(16)13-25/h3-9,14H,10-13H2,1-2H3,(H,23,26)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM216948 (US9302989, 1028) Show SMILES CCC(C)C(=O)N1CCC(CC1)Oc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1/C25H31N3O3/c1-3-18(2)24(29)27-14-12-23(13-15-27)31-22-10-8-21(9-11-22)26-25(30)28-16-19-6-4-5-7-20(19)17-28/h4-11,18,23H,3,12-17H2,1-2H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217044 (US9302989, 336) Show SMILES O=C(Nc1ccc(cc1)N1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C26H26N4O2/c31-25(20-6-2-1-3-7-20)29-16-14-28(15-17-29)24-12-10-23(11-13-24)27-26(32)30-18-21-8-4-5-9-22(21)19-30/h1-13H,14-19H2,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215877 (US9302989, 73) Show SMILES O=C(Nc1ccc(cc1)C(=O)NCc1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C23H21N3O2/c27-22(24-14-17-6-2-1-3-7-17)18-10-12-21(13-11-18)25-23(28)26-15-19-8-4-5-9-20(19)16-26/h1-13H,14-16H2,(H,24,27)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM216052 (US9302989, 252) Show SMILES CC(C)C[C@@H](CO)NC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C22H27N3O3/c1-15(2)11-20(14-26)23-21(27)16-7-9-19(10-8-16)24-22(28)25-12-17-5-3-4-6-18(17)13-25/h3-10,15,20,26H,11-14H2,1-2H3,(H,23,27)(H,24,28)/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254213 (CHEMBL4076641) Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C21H18N2O3S/c24-21(23-14-16-6-4-5-7-17(16)15-23)22-18-10-12-20(13-11-18)27(25,26)19-8-2-1-3-9-19/h1-13H,14-15H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215890 (US9302989, 86) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccc(cc3C2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H24F3N3O2/c1-14(2)9-10-26-20(29)15-4-7-19(8-5-15)27-21(30)28-12-16-3-6-18(22(23,24)25)11-17(16)13-28/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,26,29)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217027 (US9302989, 319) Show SMILES CC(C)CCn1cc(cn1)-c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C23H26N4O/c1-17(2)11-12-27-16-21(13-24-27)18-7-9-22(10-8-18)25-23(28)26-14-19-5-3-4-6-20(19)15-26/h3-10,13,16-17H,11-12,14-15H2,1-2H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM215895 (US9302989, 91) Show SMILES O=C(Nc1ccc(cc1)C(=O)NCC1CCOC1)N1Cc2ccccc2C1 Show InChI InChI=1/C21H23N3O3/c25-20(22-11-15-9-10-27-14-15)16-5-7-19(8-6-16)23-21(26)24-12-17-3-1-2-4-18(17)13-24/h1-8,15H,9-14H2,(H,22,25)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid PDB UniChem	PDB PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217157 (US9302989, 574) Show SMILES CC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cn1 Show InChI InChI=1S/C20H24N4O2/c1-14(2)9-10-21-19(25)18-8-7-17(11-22-18)23-20(26)24-12-15-5-3-4-6-16(15)13-24/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,21,25)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254189 (CHEMBL4077254) Show SMILES CC(C)CCC(=O)Nc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C21H25N3O2/c1-15(2)7-12-20(25)22-18-8-10-19(11-9-18)23-21(26)24-13-16-5-3-4-6-17(16)14-24/h3-6,8-11,15H,7,12-14H2,1-2H3,(H,22,25)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM216009 (US9302989, 209) Show SMILES CCCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C19H21N3O2/c1-2-11-20-18(23)14-7-9-17(10-8-14)21-19(24)22-12-15-5-3-4-6-16(15)13-22/h3-10H,2,11-13H2,1H3,(H,20,23)(H,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	104	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254185 (CHEMBL4081887) Show SMILES COC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C17H16N2O3/c1-22-16(20)12-6-8-15(9-7-12)18-17(21)19-10-13-4-2-3-5-14(13)11-19/h2-9H,10-11H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50254186 (CHEMBL4099778) Show SMILES CN(CCC(C)(C)C)C(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C23H29N3O2/c1-23(2,3)13-14-25(4)21(27)17-9-11-20(12-10-17)24-22(28)26-15-18-7-5-6-8-19(18)16-26/h5-12H,13-16H2,1-4H3,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem Similars	PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM217207 (US9302989, 808) Show SMILES CC(C)CCNS(=O)(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C20H25N3O3S/c1-15(2)11-12-21-27(25,26)19-9-7-18(8-10-19)22-20(24)23-13-16-5-3-4-6-17(16)14-23/h3-10,15,21H,11-14H2,1-2H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50439314 (CHEMBL2419508) Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)N1Cc2ccccc2C1 Show InChI InChI=1S/C22H20N2O3S/c25-22(24-15-18-6-4-5-7-19(18)16-24)23-14-17-10-12-21(13-11-17)28(26,27)20-8-2-1-3-9-20/h1-13H,14-16H2,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	PubMed	487	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM216050 (US9302989, 250) Show SMILES NC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C16H15N3O2/c17-15(20)11-5-7-14(8-6-11)18-16(21)19-9-12-3-1-2-4-13(12)10-19/h1-8H,9-10H2,(H2,17,20)(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM253899 (US9459250, E104) Show SMILES Cc1ccc(NC(=O)N2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C16H16N2O/c1-12-6-8-15(9-7-12)17-16(19)18-10-13-4-2-3-5-14(13)11-18/h2-9H,10-11H2,1H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc Curated by ChEMBL					Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...				Bioorg Med Chem Lett 27: 3317-3325 (2017)
					More data for this Ligand-Target Pair

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