Compile Data Set for Download or QSAR

Found 2723 hits Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50011266 (CHEMBL3260358) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Mus musculus)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Mus musculus)	BDBM50011266 (CHEMBL3260358) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry				Bioorg Med Chem Lett 23: 5488-97 (2013) Article DOI: 10.1016/j.bmcl.2013.08.074 BindingDB Entry DOI: 10.7270/Q2DF6SQ1
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81395 (APO-866) Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 Show InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL					Assay Description Noncompetitive inhibition of NAMPT (unknown origin)				J Med Chem 56: 6279-96 (2013) Article DOI: 10.1021/jm4001049 BindingDB Entry DOI: 10.7270/Q25Q4XJ8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50117198 (4-{[7-Chloro-3-methyl-2-(4-methyl-piperazin-1-ylme...) Show SMILES CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4cccnc4)cc3c(=O)n2C)CC1 Show InChI InChI=1S/C32H34ClN7O2/c1-4-12-40(26-9-7-24(8-10-26)31(41)35-20-23-6-5-11-34-19-23)21-25-17-27-29(18-28(25)33)36-30(38(3)32(27)42)22-39-15-13-37(2)14-16-39/h1,5-11,17-19H,12-16,20-22H2,2-3H3,(H,35,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81392 (MPI-0482593) Show SMILES CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4ccccn4)cc3c(=O)n2C)CC1 Show InChI InChI=1S/C32H34ClN7O2/c1-4-13-40(26-10-8-23(9-11-26)31(41)35-20-25-7-5-6-12-34-25)21-24-18-27-29(19-28(24)33)36-30(38(3)32(27)42)22-39-16-14-37(2)15-17-39/h1,5-12,18-19H,13-17,20-22H2,2-3H3,(H,35,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81393 (MPI-0479883) Show SMILES Cn1c(CN2CCN(CCN)CC2)nc2cc(Cl)c(CN(CC#C)c3ccc(cc3)C(=O)NCc3cccnc3)cc2c1=O Show InChI InChI=1S/C33H37ClN8O2/c1-3-12-42(27-8-6-25(7-9-27)32(43)37-21-24-5-4-11-36-20-24)22-26-18-28-30(19-29(26)34)38-31(39(2)33(28)44)23-41-16-14-40(13-10-35)15-17-41/h1,4-9,11,18-20H,10,12-17,21-23,35H2,2H3,(H,37,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81394 (MPI-0482594) Show SMILES Cn1c(CN2CCN(CCN)CC2)nc2cc(Cl)c(CN(CC#C)c3ccc(cc3)C(=O)NCc3ccccn3)cc2c1=O Show InChI InChI=1S/C33H37ClN8O2/c1-3-13-42(27-9-7-24(8-10-27)32(43)37-21-26-6-4-5-12-36-26)22-25-19-28-30(20-29(25)34)38-31(39(2)33(28)44)23-41-17-15-40(14-11-35)16-18-41/h1,4-10,12,19-20H,11,13-18,21-23,35H2,2H3,(H,37,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81395 (APO-866) Show SMILES O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 Show InChI InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81396 (GMX1778) Show SMILES Clc1ccc(OCCCCCCNC(NC#N)=Nc2ccncc2)cc1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).					Assay Description The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...				Chembiochem 15: 1121-30 (2014) Article DOI: 10.1002/cbic.201402023 BindingDB Entry DOI: 10.7270/Q2X065QR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM112625 (GNE-643) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccn3ccnc3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-10-17(23)12-19(11-16)30(28,29)18-3-1-14(2-4-18)13-25-21(27)15-5-7-26-8-6-24-20(26)9-15/h1-12H,13H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).					Assay Description The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...				Chembiochem 15: 1121-30 (2014) Article DOI: 10.1002/cbic.201402023 BindingDB Entry DOI: 10.7270/Q2X065QR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM112626 (GNE-200) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3cccn3c2)cc1 Show InChI InChI=1S/C22H16F2N2O3S/c23-17-10-18(24)12-21(11-17)30(28,29)20-7-3-15(4-8-20)13-25-22(27)16-5-6-19-2-1-9-26(19)14-16/h1-12,14H,13H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).					Assay Description The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...				Chembiochem 15: 1121-30 (2014) Article DOI: 10.1002/cbic.201402023 BindingDB Entry DOI: 10.7270/Q2X065QR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM112627 (GNE-201) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccn3cccc3c2)cc1 Show InChI InChI=1S/C22H16F2N2O3S/c23-17-11-18(24)13-21(12-17)30(28,29)20-5-3-15(4-6-20)14-25-22(27)16-7-9-26-8-1-2-19(26)10-16/h1-13H,14H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).					Assay Description The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...				Chembiochem 15: 1121-30 (2014) Article DOI: 10.1002/cbic.201402023 BindingDB Entry DOI: 10.7270/Q2X065QR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81396 (GMX1778) Show SMILES Clc1ccc(OCCCCCCNC(NC#N)=Nc2ccncc2)cc1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).					Assay Description The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...				Chembiochem 15: 1121-30 (2014) Article DOI: 10.1002/cbic.201402023 BindingDB Entry DOI: 10.7270/Q2X065QR
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM60806 (US9169209, Table 3, Compound 3) Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2)\C=C\c1cccnc1 Show InChI InChI=1S/C20H21N3O4S/c24-20(10-3-15-2-1-11-21-12-15)22-16-4-8-19(9-5-16)28(25,26)23-13-17-6-7-18(14-23)27-17/h1-5,8-12,17-18H,6-7,13-14H2,(H,22,24)/b10-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187025 (US9169209, Table 3, Compound 58) Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2Sc3ccccc3Oc12)\C=C\c1cccnc1 Show InChI InChI=1S/C26H18N2O4S2/c29-25(15-10-18-5-4-16-27-17-18)28-19-11-13-20(14-12-19)34(30,31)24-9-3-8-23-26(24)32-21-6-1-2-7-22(21)33-23/h1-17H,(H,28,29)/b15-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187026 (US9169209, Table 3, Compound 59) Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)\C=C\c1cccnc1 Show InChI InChI=1S/C21H18N2O3S/c24-21(13-10-17-5-4-14-22-15-17)23-16-18-8-11-20(12-9-18)27(25,26)19-6-2-1-3-7-19/h1-15H,16H2,(H,23,24)/b13-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187027 (US9169209, Table 3, Compound 60) Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C20H14Cl2N2O3S/c21-15-4-9-18(22)19(12-15)28(26,27)17-7-5-16(6-8-17)24-20(25)10-3-14-2-1-11-23-13-14/h1-13H,(H,24,25)/b10-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22.4	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187028 (US9169209, Table 3, Compound 61) Show SMILES COc1ccc(C)cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H20N2O4S/c1-16-5-11-20(28-2)21(14-16)29(26,27)19-9-7-18(8-10-19)24-22(25)12-6-17-4-3-13-23-15-17/h3-15H,1-2H3,(H,24,25)/b12-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187029 (US9169209, Table 3, Compound 62) Show SMILES COc1ccccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H18N2O4S/c1-27-19-6-2-3-7-20(19)28(25,26)18-11-9-17(10-12-18)23-21(24)13-8-16-5-4-14-22-15-16/h2-15H,1H3,(H,23,24)/b13-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187030 (US9169209, Table 3, Compound 63) Show SMILES Cc1ccccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H18N2O3S/c1-16-5-2-3-7-20(16)27(25,26)19-11-9-18(10-12-19)23-21(24)13-8-17-6-4-14-22-15-17/h2-15H,1H3,(H,23,24)/b13-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187031 (US9169209, Table 3, Compound 64) Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C20H14Cl2N2O3S/c21-18-9-8-17(12-19(18)22)28(26,27)16-6-4-15(5-7-16)24-20(25)10-3-14-2-1-11-23-13-14/h1-13H,(H,24,25)/b10-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	72.9	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187032 (US9169209, Table 3, Compound 65) Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H20N2O5S/c1-28-20-11-10-19(14-21(20)29-2)30(26,27)18-8-6-17(7-9-18)24-22(25)12-5-16-4-3-13-23-15-16/h3-15H,1-2H3,(H,24,25)/b12-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187033 (US9169209, Table 3, Compound 66) Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C20H14Cl2N2O3S/c21-15-10-16(22)12-19(11-15)28(26,27)18-6-4-17(5-7-18)24-20(25)8-3-14-2-1-9-23-13-14/h1-13H,(H,24,25)/b8-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50.5	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187034 (US9169209, Table 3, Compound 67) Show SMILES COc1cc(OC)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H20N2O5S/c1-28-18-12-19(29-2)14-21(13-18)30(26,27)20-8-6-17(7-9-20)24-22(25)10-5-16-4-3-11-23-15-16/h3-15H,1-2H3,(H,24,25)/b10-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187035 (US9169209, Table 3, Compound 68) Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H20N2O3S/c1-16-12-17(2)14-21(13-16)28(26,27)20-8-6-19(7-9-20)24-22(25)10-5-18-4-3-11-23-15-18/h3-15H,1-2H3,(H,24,25)/b10-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.1	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187036 (US9169209, Table 3, Compound 69) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17ClN2O4S/c1-28-20-10-9-18(13-19(20)22)29(26,27)17-7-5-16(6-8-17)24-21(25)11-4-15-3-2-12-23-14-15/h2-14H,1H3,(H,24,25)/b11-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187037 (US9169209, Table 3, Compound 70) Show SMILES Cc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17ClN2O3S/c1-15-4-8-19(13-20(15)22)28(26,27)18-9-6-17(7-10-18)24-21(25)11-5-16-3-2-12-23-14-16/h2-14H,1H3,(H,24,25)/b11-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187038 (US9169209, Table 3, Compound 71) Show SMILES CCCOc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C23H21ClN2O4S/c1-2-14-30-22-11-10-20(15-21(22)24)31(28,29)19-8-6-18(7-9-19)26-23(27)12-5-17-4-3-13-25-16-17/h3-13,15-16H,2,14H2,1H3,(H,26,27)/b12-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187039 (US9169209, Table 3, Compound 72) Show SMILES Fc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C20H14ClFN2O3S/c21-15-10-16(22)12-19(11-15)28(26,27)18-6-4-17(5-7-18)24-20(25)8-3-14-2-1-9-23-13-14/h1-13H,(H,24,25)/b8-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187040 (US9169209, Table 3, Compound 73) Show SMILES COc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17ClN2O4S/c1-28-18-11-16(22)12-20(13-18)29(26,27)19-7-5-17(6-8-19)24-21(25)9-4-15-3-2-10-23-14-15/h2-14H,1H3,(H,24,25)/b9-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187041 (US9169209, Table 3, Compound 74) Show SMILES Cc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17ClN2O3S/c1-15-11-17(22)13-20(12-15)28(26,27)19-7-5-18(6-8-19)24-21(25)9-4-16-3-2-10-23-14-16/h2-14H,1H3,(H,24,25)/b9-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187042 (US9169209, Table 3, Compound 75) Show SMILES Clc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C20H15ClN2O3S/c21-16-4-1-5-19(13-16)27(25,26)18-9-7-17(8-10-18)23-20(24)11-6-15-3-2-12-22-14-15/h1-14H,(H,23,24)/b11-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187043 (US9169209, Table 3, Compound 76) Show SMILES CCS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H21N3O5S2/c1-2-31(27,28)25-19-6-3-7-21(15-19)32(29,30)20-11-9-18(10-12-20)24-22(26)13-8-17-5-4-14-23-16-17/h3-16,25H,2H2,1H3,(H,24,26)/b13-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187044 (US9169209, Table 3, Compound 77) Show SMILES CCOc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H20N2O4S/c1-2-28-19-6-3-7-21(15-19)29(26,27)20-11-9-18(10-12-20)24-22(25)13-8-17-5-4-14-23-16-17/h3-16H,2H2,1H3,(H,24,25)/b13-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	57.2	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187045 (US9169209, Table 3, Compound 78) Show SMILES CCc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C22H20N2O3S/c1-2-17-5-3-7-21(15-17)28(26,27)20-11-9-19(10-12-20)24-22(25)13-8-18-6-4-14-23-16-18/h3-16H,2H2,1H3,(H,24,25)/b13-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187046 (US9169209, Table 3, Compound 79) Show SMILES COc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17FN2O4S/c1-28-20-10-9-18(13-19(20)22)29(26,27)17-7-5-16(6-8-17)24-21(25)11-4-15-3-2-12-23-14-15/h2-14H,1H3,(H,24,25)/b11-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.5	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187047 (US9169209, Table 3, Compound 80) Show SMILES Cc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17FN2O3S/c1-15-4-8-19(13-20(15)22)28(26,27)18-9-6-17(7-10-18)24-21(25)11-5-16-3-2-12-23-14-16/h2-14H,1H3,(H,24,25)/b11-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27.6	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187048 (US9169209, Table 3, Compound 81) Show SMILES CCCOc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C23H21FN2O4S/c1-2-14-30-22-11-10-20(15-21(22)24)31(28,29)19-8-6-18(7-9-19)26-23(27)12-5-17-4-3-13-25-16-17/h3-13,15-16H,2,14H2,1H3,(H,26,27)/b12-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40.9	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187049 (US9169209, Table 3, Compound 82) Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17FN2O4S/c1-28-18-11-16(22)12-20(13-18)29(26,27)19-7-5-17(6-8-19)24-21(25)9-4-15-3-2-10-23-14-15/h2-14H,1H3,(H,24,25)/b9-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187050 (US9169209, Table 3, Compound 83) Show SMILES Cc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17FN2O3S/c1-15-11-17(22)13-20(12-15)28(26,27)19-7-5-18(6-8-19)24-21(25)9-4-16-3-2-10-23-14-16/h2-14H,1H3,(H,24,25)/b9-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.5	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187051 (US9169209, Table 3, Compound 84) Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C20H15FN2O3S/c21-16-4-1-5-19(13-16)27(25,26)18-9-7-17(8-10-18)23-20(24)11-6-15-3-2-12-22-14-15/h1-14H,(H,23,24)/b11-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	66.4	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187052 (US9169209, Table 3, Compound 85) Show SMILES CS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H19N3O5S2/c1-30(26,27)24-18-5-2-6-20(14-18)31(28,29)19-10-8-17(9-11-19)23-21(25)12-7-16-4-3-13-22-15-16/h2-15,24H,1H3,(H,23,25)/b12-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187053 (US9169209, Table 3, Compound 86) Show SMILES CS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H18N2O5S2/c1-29(25,26)19-5-2-6-20(14-19)30(27,28)18-10-8-17(9-11-18)23-21(24)12-7-16-4-3-13-22-15-16/h2-15H,1H3,(H,23,24)/b12-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187054 (US9169209, Table 3, Compound 87) Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H18N2O4S/c1-27-18-5-2-6-20(14-18)28(25,26)19-10-8-17(9-11-19)23-21(24)12-7-16-4-3-13-22-15-16/h2-15H,1H3,(H,23,24)/b12-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	85.7	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187055 (US9169209, Table 3, Compound 88) Show SMILES Cc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H18N2O3S/c1-16-4-2-6-20(14-16)27(25,26)19-10-8-18(9-11-19)23-21(24)12-7-17-5-3-13-22-15-17/h2-15H,1H3,(H,23,24)/b12-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187056 (US9169209, Table 3, Compound 89) Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc(c1)-c1ccccc1)\C=C\c1cccnc1 Show InChI InChI=1S/C26H20N2O3S/c29-26(16-11-20-6-5-17-27-19-20)28-23-12-14-24(15-13-23)32(30,31)25-10-4-9-22(18-25)21-7-2-1-3-8-21/h1-19H,(H,28,29)/b16-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25.4	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187057 (US9169209, Table 3, Compound 90) Show SMILES CCCOc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C23H22N2O4S/c1-2-15-29-20-6-3-7-22(16-20)30(27,28)21-11-9-19(10-12-21)25-23(26)13-8-18-5-4-14-24-17-18/h3-14,16-17H,2,15H2,1H3,(H,25,26)/b13-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair

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