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Compile Data Set for Download or QSAR

Found 72 hits Enz. Inhib. hit(s) with Target = 'Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50238419
PNG
(CHEMBL4060134)
Show SMILES Cn1cnc(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1
Show InChI InChI=1S/C24H22N10O2/c1-31-14-19(25-15-31)24(36)33-12-10-32(11-13-33)23(35)16-6-8-17(9-7-16)26-21-22-28-29-30-34(22)20-5-3-2-4-18(20)27-21/h2-9,14-15H,10-13H2,1H3,(H,26,27)
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n/an/an/an/a 2.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human alpha1 nAChR


J Med Chem 60: 5455-5471 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00137
BindingDB Entry DOI: 10.7270/Q2X350RS
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50049756
PNG
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Show SMILES CN1CCC[C@H]1COc1cccnc1
Show InChI InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1
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n/an/an/an/a 3.40E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for functional activity against alpha1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflu...


Bioorg Med Chem Lett 7: 2703-2708 (1997)


Article DOI: 10.1016/S0960-894X(97)10080-4
BindingDB Entry DOI: 10.7270/Q2Z60P30
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232596
PNG
(CHEMBL4064914)
Show SMILES C1N=C(Nc2ccncn2)OC11CN2CCC1CC2
Show InChI InChI=1/C13H17N5O/c1-4-14-9-16-11(1)17-12-15-7-13(19-12)8-18-5-2-10(13)3-6-18/h1,4,9-10H,2-3,5-8H2,(H,14,15,16,17)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Rattus norvegicus-RAT)
BDBM50206243
PNG
(CHEMBL3918431)
Show SMILES C1N=C(Nc2cc3ccccc3cn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C18H20N4O/c1-2-4-14-10-19-16(9-13(14)3-1)21-17-20-11-18(23-17)12-22-7-5-15(18)6-8-22/h1-4,9-10,15H,5-8,11-12H2,(H,19,20,21)/t18-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at rat alpha1beta1delta1epsilon nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay


ACS Med Chem Lett 8: 366-371 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00032
BindingDB Entry DOI: 10.7270/Q2S46V8B
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Rattus norvegicus-RAT)
BDBM50235306
PNG
(CHEMBL4084621)
Show SMILES C1N=C(Nc2cc(ncn2)-n2ccnc2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C16H19N7O/c1-4-22-5-2-12(1)16(9-22)8-18-15(24-16)21-13-7-14(20-10-19-13)23-6-3-17-11-23/h3,6-7,10-12H,1-2,4-5,8-9H2,(H,18,19,20,21)/t16-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at rat alpha1beta1delta1epsilon nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay


ACS Med Chem Lett 8: 366-371 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00032
BindingDB Entry DOI: 10.7270/Q2S46V8B
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232610
PNG
(CHEMBL4089244)
Show SMILES COc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1
Show InChI InChI=1/C14H19N5O2/c1-20-11-6-15-12(16-7-11)18-13-17-8-14(21-13)9-19-4-2-10(14)3-5-19/h6-7,10H,2-5,8-9H2,1H3,(H,15,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50290628
PNG
(2-((S)-1-Methyl-pyrrolidin-2-yl)-furo[3,2-b]pyridi...)
Show SMILES CN1CCC[C@H]1c1cc2ncccc2o1
Show InChI InChI=1S/C12H14N2O/c1-14-7-3-4-10(14)12-8-9-11(15-12)5-2-6-13-9/h2,5-6,8,10H,3-4,7H2,1H3/t10-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for functional activity against alpha1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflu...


Bioorg Med Chem Lett 7: 2703-2708 (1997)


Article DOI: 10.1016/S0960-894X(97)10080-4
BindingDB Entry DOI: 10.7270/Q2Z60P30
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Rattus norvegicus-RAT)
BDBM50206243
PNG
(CHEMBL3918431)
Show SMILES C1N=C(Nc2cc3ccccc3cn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C18H20N4O/c1-2-4-14-10-19-16(9-13(14)3-1)21-17-20-11-18(23-17)12-22-7-5-15(18)6-8-22/h1-4,9-10,15H,5-8,11-12H2,(H,19,20,21)/t18-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at rat alpha1beta1deltaepsilon nAChR expressed in HEK293 cells for 2 mins by FLIPR assay


J Med Chem 59: 11171-11181 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01506
BindingDB Entry DOI: 10.7270/Q2NS0X2H
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232602
PNG
(CHEMBL4097654)
Show SMILES Clc1cc(NC2=NC[C@@]3(CN4CCC3CC4)O2)ncn1
Show InChI InChI=1/C13H16ClN5O/c14-10-5-11(17-8-16-10)18-12-15-6-13(20-12)7-19-3-1-9(13)2-4-19/h5,8-9H,1-4,6-7H2,(H,15,16,17,18)/t13-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232600
PNG
(CHEMBL4074583)
Show SMILES COc1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1
Show InChI InChI=1/C14H19N5O2/c1-20-11-2-5-15-12(17-11)18-13-16-8-14(21-13)9-19-6-3-10(14)4-7-19/h2,5,10H,3-4,6-9H2,1H3,(H,15,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232594
PNG
(CHEMBL4102566)
Show SMILES C1N=C(Nc2cc(ncn2)-c2ccccc2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C19H21N5O/c1-2-4-14(5-3-1)16-10-17(22-13-21-16)23-18-20-11-19(25-18)12-24-8-6-15(19)7-9-24/h1-5,10,13,15H,6-9,11-12H2,(H,20,21,22,23)/t19-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232595
PNG
(CHEMBL4100355)
Show SMILES C1N=C(Nc2ncccn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C13H17N5O/c1-4-14-11(15-5-1)17-12-16-8-13(19-12)9-18-6-2-10(13)3-7-18/h1,4-5,10H,2-3,6-9H2,(H,14,15,16,17)/t13-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232598
PNG
(CHEMBL4084852)
Show SMILES Cc1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1
Show InChI InChI=1/C14H19N5O/c1-10-2-5-15-12(17-10)18-13-16-8-14(20-13)9-19-6-3-11(14)4-7-19/h2,5,11H,3-4,6-9H2,1H3,(H,15,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232616
PNG
(CHEMBL4101249)
Show SMILES COc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)cn1
Show InChI InChI=1/C14H19N5O2/c1-20-12-7-15-11(6-16-12)18-13-17-8-14(21-13)9-19-4-2-10(14)3-5-19/h6-7,10H,2-5,8-9H2,1H3,(H,15,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232601
PNG
(CHEMBL4079623)
Show SMILES COc1cc(NC2=NC[C@@]3(CN4CCC3CC4)O2)ncn1
Show InChI InChI=1/C14H19N5O2/c1-20-12-6-11(16-9-17-12)18-13-15-7-14(21-13)8-19-4-2-10(14)3-5-19/h6,9-10H,2-5,7-8H2,1H3,(H,15,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232617
PNG
(CHEMBL4066807)
Show SMILES CC(C)c1cc(NC2=NC[C@@]3(CN4CCC3CC4)O2)ncn1
Show InChI InChI=1/C16H23N5O/c1-11(2)13-7-14(19-10-18-13)20-15-17-8-16(22-15)9-21-5-3-12(16)4-6-21/h7,10-12H,3-6,8-9H2,1-2H3,(H,17,18,19,20)/t16-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232611
PNG
(CHEMBL4071859)
Show SMILES C1N=C(Nc2ncc3ccccc3n2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C17H19N5O/c1-2-4-14-12(3-1)9-18-15(20-14)21-16-19-10-17(23-16)11-22-7-5-13(17)6-8-22/h1-4,9,13H,5-8,10-11H2,(H,18,19,20,21)/t17-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232606
PNG
(CHEMBL4083246)
Show SMILES Cc1cncc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1
Show InChI InChI=1/C14H19N5O/c1-10-6-15-7-12(17-10)18-13-16-8-14(20-13)9-19-4-2-11(14)3-5-19/h6-7,11H,2-5,8-9H2,1H3,(H,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232599
PNG
(CHEMBL4095046)
Show SMILES CC(C)c1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1
Show InChI InChI=1/C16H23N5O/c1-11(2)13-3-6-17-14(19-13)20-15-18-9-16(22-15)10-21-7-4-12(16)5-8-21/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,17,18,19,20)/t16-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232612
PNG
(CHEMBL4098850)
Show SMILES C1N=C(Nc2cc3cccnc3cn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C17H19N5O/c1-2-12-8-15(19-9-14(12)18-5-1)21-16-20-10-17(23-16)11-22-6-3-13(17)4-7-22/h1-2,5,8-9,13H,3-4,6-7,10-11H2,(H,19,20,21)/t17-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232609
PNG
(CHEMBL4098776)
Show SMILES C1N=C(Nc2nccc(n2)-c2ccccc2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C19H21N5O/c1-2-4-14(5-3-1)16-6-9-20-17(22-16)23-18-21-12-19(25-18)13-24-10-7-15(19)8-11-24/h1-6,9,15H,7-8,10-13H2,(H,20,21,22,23)/t19-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232615
PNG
(CHEMBL4091037)
Show SMILES Cc1nccnc1NC1=NC[C@@]2(CN3CCC2CC3)O1
Show InChI InChI=1/C14H19N5O/c1-10-12(16-5-4-15-10)18-13-17-8-14(20-13)9-19-6-2-11(14)3-7-19/h4-5,11H,2-3,6-9H2,1H3,(H,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232593
PNG
(CHEMBL4087500)
Show SMILES C1N=C(Nc2cnccn2)OC11CN2CCC1CC2
Show InChI InChI=1/C13H17N5O/c1-5-18-6-2-10(1)13(9-18)8-16-12(19-13)17-11-7-14-3-4-15-11/h3-4,7,10H,1-2,5-6,8-9H2,(H,15,16,17)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232613
PNG
(CHEMBL4061082)
Show SMILES Cc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1
Show InChI InChI=1/C14H19N5O/c1-10-6-15-12(16-7-10)18-13-17-8-14(20-13)9-19-4-2-11(14)3-5-19/h6-7,11H,2-5,8-9H2,1H3,(H,15,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50211215
PNG
(CHEMBL3898922)
Show SMILES C1N=C(Nc2ccccn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C14H18N4O/c1-2-6-15-12(3-1)17-13-16-9-14(19-13)10-18-7-4-11(14)5-8-18/h1-3,6,11H,4-5,7-10H2,(H,15,16,17)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232597
PNG
(CHEMBL4092614)
Show SMILES C1N=C(Nc2cncnc2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C13H17N5O/c1-3-18-4-2-10(1)13(8-18)7-16-12(19-13)17-11-5-14-9-15-6-11/h5-6,9-10H,1-4,7-8H2,(H,16,17)/t13-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50206243
PNG
(CHEMBL3918431)
Show SMILES C1N=C(Nc2cc3ccccc3cn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C18H20N4O/c1-2-4-14-10-19-16(9-13(14)3-1)21-17-20-11-18(23-17)12-22-7-5-15(18)6-8-22/h1-4,9-10,15H,5-8,11-12H2,(H,19,20,21)/t18-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232604
PNG
(CHEMBL4093500)
Show SMILES C1N=C(Nc2cnc(cn2)-c2ccccc2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C19H21N5O/c1-2-4-14(5-3-1)16-10-21-17(11-20-16)23-18-22-12-19(25-18)13-24-8-6-15(19)7-9-24/h1-5,10-11,15H,6-9,12-13H2,(H,21,22,23)/t19-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232603
PNG
(CHEMBL4075880)
Show SMILES Cc1cc(NC2=NC[C@@]3(CN4CCC3CC4)O2)ncn1
Show InChI InChI=1/C14H19N5O/c1-10-6-12(17-9-16-10)18-13-15-7-14(20-13)8-19-4-2-11(14)3-5-19/h6,9,11H,2-5,7-8H2,1H3,(H,15,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232605
PNG
(CHEMBL4077222)
Show SMILES Clc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)cn1
Show InChI InChI=1/C13H16ClN5O/c14-10-5-16-11(6-15-10)18-12-17-7-13(20-12)8-19-3-1-9(13)2-4-19/h5-6,9H,1-4,7-8H2,(H,16,17,18)/t13-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232614
PNG
(CHEMBL4102804)
Show SMILES C1N=C(Nc2cnccn2)O[C@]11CN2CCC1CC2
Show InChI InChI=1/C13H17N5O/c1-5-18-6-2-10(1)13(9-18)8-16-12(19-13)17-11-7-14-3-4-15-11/h3-4,7,10H,1-2,5-6,8-9H2,(H,15,16,17)/t13-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232608
PNG
(CHEMBL4071766)
Show SMILES Cc1cccc(c1)-c1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1
Show InChI InChI=1/C20H23N5O/c1-14-3-2-4-15(9-14)16-10-21-18(22-11-16)24-19-23-12-20(26-19)13-25-7-5-17(20)6-8-25/h2-4,9-11,17H,5-8,12-13H2,1H3,(H,21,22,23,24)/t20-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50232607
PNG
(CHEMBL4063152)
Show SMILES Cc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)cn1
Show InChI InChI=1/C14H19N5O/c1-10-6-16-12(7-15-10)18-13-17-8-14(20-13)9-19-4-2-11(14)3-5-19/h6-7,11H,2-5,8-9H2,1H3,(H,16,17,18)/t14-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based ...


Bioorg Med Chem Lett 27: 1261-1266 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.058
BindingDB Entry DOI: 10.7270/Q2FJ2K1D
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/s2
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n/an/an/an/a 1.80E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for functional activity against alpha1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflu...


Bioorg Med Chem Lett 7: 2703-2708 (1997)


Article DOI: 10.1016/S0960-894X(97)10080-4
BindingDB Entry DOI: 10.7270/Q2Z60P30
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50035398
PNG
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Show SMILES CN1CCC[C@H]1c1cc(C)no1
Show InChI InChI=1/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/s2
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n/an/an/an/a 4.11E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for functional activity against alpha1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflu...


Bioorg Med Chem Lett 7: 2703-2708 (1997)


Article DOI: 10.1016/S0960-894X(97)10080-4
BindingDB Entry DOI: 10.7270/Q2Z60P30
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50290629
PNG
((S)-2-Pyrrolidin-2-yl-furo[3,2-b]pyridine | CHEMBL...)
Show SMILES C1CN[C@@H](C1)c1cc2ncccc2o1
Show InChI InChI=1S/C11H12N2O/c1-3-8(12-5-1)11-7-9-10(14-11)4-2-6-13-9/h2,4,6-8,12H,1,3,5H2/t8-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in K177 cells using isotopic rubidium efflux assay.


Bioorg Med Chem Lett 7: 2703-2708 (1997)


Article DOI: 10.1016/S0960-894X(97)10080-4
BindingDB Entry DOI: 10.7270/Q2Z60P30
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50045044
PNG
(CHEMBL3341967)
Show SMILES Clc1cncc(c1)N1CCCNCC1
Show InChI InChI=1S/C10H14ClN3/c11-9-6-10(8-13-7-9)14-4-1-2-12-3-5-14/h6-8,12H,1-5H2
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944n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Partial agonist activity at alpha1 nAChR (unknown origin)


J Med Chem 57: 8204-23 (2014)


Article DOI: 10.1021/jm401937a
BindingDB Entry DOI: 10.7270/Q2KW5HPX
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50022784
PNG
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Show SMILES CNCCC(Oc1ccccc1C)c1ccccc1
Show InChI InChI=1/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
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1.00E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Neuropsychopharmacology 27: 699-711 (2002)


Article DOI: 10.1016/S0893-133X(02)00346-9
BindingDB Entry DOI: 10.7270/Q2GQ6W98
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50170601
PNG
((1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.0^{1,10...)
Show SMILES C1C[C@@]23CN1CC[C@@H]2Oc1cccnc1C3
Show InChI InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1
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6.00E+3n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 306: 407-20 (2003)


Article DOI: 10.1124/jpet.103.049262
BindingDB Entry DOI: 10.7270/Q2GM85WX
More data for this
Ligand-Target Pair
alpha-1 Nicotinic AChR


(Homo sapiens (Human))
BDBM50010588
PNG
((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Show SMILES CNC(C)Cc1ccc2OCOc2c1
Show InChI InChI=1/C11H15NO2/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10/h3-4,6,8,12H,5,7H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




Mol Pharmacol 63: 1223-9 (2003)


Article DOI: 10.1124/mol.63.6.1223
BindingDB Entry DOI: 10.7270/Q2FN14SJ
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50111638
PNG
(CHEMBL16044 | N-[(S)-1-(11-Amino-undecylcarbamoyl)...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCCCN
Show InChI InChI=1S/C24H41N3O3/c1-2-12-23(29)27-22(19-20-13-15-21(28)16-14-20)24(30)26-18-11-9-7-5-3-4-6-8-10-17-25/h13-16,22,28H,2-12,17-19,25H2,1H3,(H,26,30)(H,27,29)/t22-/m0/s1
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n/an/a 580n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50094299
PNG
(CHEMBL15998 | N-[(S)-1-(12-Amino-dodecylcarbamoyl)...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCCCCN
Show InChI InChI=1S/C25H43N3O3/c1-2-13-24(30)28-23(20-21-14-16-22(29)17-15-21)25(31)27-19-12-10-8-6-4-3-5-7-9-11-18-26/h14-17,23,29H,2-13,18-20,26H2,1H3,(H,27,31)(H,28,30)/t23-/m0/s1
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n/an/a 930n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50111637
PNG
(CHEMBL279418 | N-[(S)-1-(9-Amino-nonylcarbamoyl)-2...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCN
Show InChI InChI=1S/C22H37N3O3/c1-2-10-21(27)25-20(17-18-11-13-19(26)14-12-18)22(28)24-16-9-7-5-3-4-6-8-15-23/h11-14,20,26H,2-10,15-17,23H2,1H3,(H,24,28)(H,25,27)/t20-/m0/s1
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n/an/a 1.51E+4n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50094298
PNG
(CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCNCCCN
Show InChI InChI=1S/C23H41N5O3/c1-2-7-22(30)28-21(18-19-8-10-20(29)11-9-19)23(31)27-17-6-16-26-14-4-3-13-25-15-5-12-24/h8-11,21,25-26,29H,2-7,12-18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50111640
PNG
(CHEMBL16607 | N-[(S)-1-(10-Amino-decylcarbamoyl)-2...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCCN
Show InChI InChI=1S/C23H39N3O3/c1-2-11-22(28)26-21(18-19-12-14-20(27)15-13-19)23(29)25-17-10-8-6-4-3-5-7-9-16-24/h12-15,21,27H,2-11,16-18,24H2,1H3,(H,25,29)(H,26,28)/t21-/m0/s1
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n/an/a 8.66E+3n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50111639
PNG
(CHEMBL16184 | N-[(S)-1-(7-Amino-heptylcarbamoyl)-2...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCN
Show InChI InChI=1S/C20H33N3O3/c1-2-8-19(25)23-18(15-16-9-11-17(24)12-10-16)20(26)22-14-7-5-3-4-6-13-21/h9-12,18,24H,2-8,13-15,21H2,1H3,(H,22,26)(H,23,25)/t18-/m0/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50094299
PNG
(CHEMBL15998 | N-[(S)-1-(12-Amino-dodecylcarbamoyl)...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCCCCN
Show InChI InChI=1S/C25H43N3O3/c1-2-13-24(30)28-23(20-21-14-16-22(29)17-15-21)25(31)27-19-12-10-8-6-4-3-5-7-9-11-18-26/h14-17,23,29H,2-13,18-20,26H2,1H3,(H,27,31)(H,28,30)/t23-/m0/s1
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n/an/a 1.53E+3n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Muscle-type nicotinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50111636
PNG
(CHEMBL16259 | N-[(S)-1-(8-Amino-octylcarbamoyl)-2-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCN
Show InChI InChI=1S/C21H35N3O3/c1-2-9-20(26)24-19(16-17-10-12-18(25)13-11-17)21(27)23-15-8-6-4-3-5-7-14-22/h10-13,19,25H,2-9,14-16,22H2,1H3,(H,23,27)(H,24,26)/t19-/m0/s1
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n/an/a 9.76E+3n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...


Bioorg Med Chem Lett 12: 1159-62 (2002)


Article DOI: 10.1016/s0960-894x(02)00120-8
BindingDB Entry DOI: 10.7270/Q2BC3XWG
More data for this
Ligand-Target Pair
Acetylcholine receptor protein epsilon chain


(Homo sapiens (Human))
BDBM50177174
PNG
(9-amino-5,6,7,8-tetrahydroacridin-4yl)methano | CH...)
Show SMILES Nc1c2CCCCc2nc2c(CO)cccc12
Show InChI InChI=1S/C14H16N2O/c15-13-10-5-1-2-7-12(10)16-14-9(8-17)4-3-6-11(13)14/h3-4,6,17H,1-2,5,7-8H2,(H2,15,16)
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n/an/a 125n/an/an/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase


J Med Chem 48: 7496-9 (2005)


Article DOI: 10.1021/jm058041z
BindingDB Entry DOI: 10.7270/Q20864WZ
More data for this
Ligand-Target Pair
Acetylcholine receptor protein epsilon chain


(Homo sapiens (Human))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 44n/an/an/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase


J Med Chem 48: 7496-9 (2005)


Article DOI: 10.1021/jm058041z
BindingDB Entry DOI: 10.7270/Q20864WZ
More data for this
Ligand-Target Pair
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