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Compile Data Set for Download or QSAR

Found 8611 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM50434787
PNG
(CHEMBL2386635 | US10487083, Example C | US10703751...)
Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1
Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1
PDB

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Similars

US Patent
n/an/an/an/a 3.32n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466496
PNG
(US10799507, Example 162 | [3-(Hydroxymethyl)-1,1-D...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CS(=O)(=O)C1
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n/an/an/an/a 3.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466343
PNG
((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1
PDB

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n/an/an/an/a 3.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466494
PNG
(US10799507, Example 160 | [3,3-Difluoro-1-(Hydroxy...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1
PDB

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n/an/an/an/a 3.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50530404
PNG
(CHEMBL4279883)
Show SMILES CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(cnc12)C(=O)NC[C@](C)(O)CO
Show InChI InChI=1S/C19H22F2N6O4/c1-19(30,9-28)8-24-18(29)14-7-23-17-13(22-2)6-15(26-27(14)17)25-12-5-10(20)4-11(21)16(12)31-3/h4-7,22,28,30H,8-9H2,1-3H3,(H,24,29)(H,25,26)/t19-/m0/s1
PDB

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n/an/an/an/a 3.80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay


J Med Chem 62: 8953-8972 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00443
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50530404
PNG
(CHEMBL4279883)
Show SMILES CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(cnc12)C(=O)NC[C@](C)(O)CO
Show InChI InChI=1S/C19H22F2N6O4/c1-19(30,9-28)8-24-18(29)14-7-23-17-13(22-2)6-15(26-27(14)17)25-12-5-10(20)4-11(21)16(12)31-3/h4-7,22,28,30H,8-9H2,1-3H3,(H,24,29)(H,25,26)/t19-/m0/s1
PDB

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n/an/an/an/a 3.80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay


J Med Chem 62: 8953-8972 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00443
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466346
PNG
((8S)-N-[(2S)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

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n/an/an/an/a 4n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466484
PNG
((8S)-N-[(1S,2S)-2- (3,4- difluorophenyl)-2- hydrox...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)c(F)c1
PDB

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n/an/an/an/a 4.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466344
PNG
((8S)-N-(2- cyclohexyl-2- hydroxy-ethyl)-5- (7H-pyr...)
Show SMILES OC(CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

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n/an/an/an/a 4.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466349
PNG
((8S)-N-[(2S)-2-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1
PDB

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n/an/an/an/a 4.90n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466493
PNG
(US10799507, Example 159 | [1-(Hydroxymethyl)Cyclop...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1
PDB

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n/an/an/an/a 5.10n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 6n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466345
PNG
((8S)-N-[(1S,2S)-2- cyclohexyl-2- hydroxy-1- methyl...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCCC1
PDB

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n/an/an/an/a 6.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466347
PNG
((8S)óN-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-E...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCC1
PDB

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n/an/an/an/a 6.30n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466495
PNG
(US10799507, Example 161 | [1-(Hydroxymethyl)Cycloh...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCCC1
PDB

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n/an/an/an/a 6.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50530394
PNG
(CHEMBL4561663)
Show SMILES NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O
Show InChI InChI=1S/C18H15FN6O2/c19-10-5-6-15(22-8-10)25-16-7-14(12(9-23-16)18(21)27)24-13-4-2-1-3-11(13)17(20)26/h1-9H,(H2,20,26)(H2,21,27)(H2,22,23,24,25)
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n/an/an/an/a 6.60n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay


J Med Chem 62: 8953-8972 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00443
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50530394
PNG
(CHEMBL4561663)
Show SMILES NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O
Show InChI InChI=1S/C18H15FN6O2/c19-10-5-6-15(22-8-10)25-16-7-14(12(9-23-16)18(21)27)24-13-4-2-1-3-11(13)17(20)26/h1-9H,(H2,20,26)(H2,21,27)(H2,22,23,24,25)
PDB

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n/an/an/an/a 6.60n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay


J Med Chem 62: 8953-8972 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00443
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466348
PNG
((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1
PDB

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n/an/an/an/a 7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466357
PNG
((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

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n/an/an/an/a 7.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466351
PNG
((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1
PDB

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n/an/an/an/a 7.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466492
PNG
(US10799507, Example 157 | [1-(hydroxymethyl)cyclob...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCC1
PDB

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n/an/an/an/a 9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466352
PNG
((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCOCC1
PDB

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n/an/an/an/a 10.8n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 11n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466367
PNG
((8S)-N-[(2R)-2- cyclobutyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCC1
PDB

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n/an/an/an/a 11.1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 13n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50507816
PNG
(BMS-986165 | Bms-986165 | DEUCRAVACITINIB | Deucra...)
Show SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Show InChI InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)/i1D3
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n/an/an/an/a 13n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of TYK2 in human whole blood assessed as reduction in IFN-alpha stimulated TYK2 phosphorylation


Bioorg Med Chem Lett 29: 2034-2041 (2019)


Article DOI: 10.1016/j.bmcl.2019.06.042
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466354
PNG
((8S)-N-[(2R)-2-(5- fluoro-2-pyridyl)- 2-hydroxy-et...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cn1
PDB

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n/an/an/an/a 13.9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466489
PNG
((3,3-Difluorocyclobutyl)Methyl (8S)-5-(7H-Pyrrolo[...)
Show SMILES FC1(F)CC(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1
PDB

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n/an/an/an/a 15.7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 17n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466350
PNG
((8S)-N-[(2S)-2-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
PDB

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n/an/an/an/a 17.7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466353
PNG
((8S)-N-[(2R)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1
PDB

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n/an/an/an/a 18.2n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466365
PNG
((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...)
Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1
PDB

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n/an/an/an/a 19.8n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466366
PNG
((8S)-N-[(1R)-1- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1
PDB

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n/an/an/an/a 19.9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466359
PNG
((8S)-N-[(1R)-1-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1
PDB

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n/an/an/an/a 20.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466485
PNG
((8S)-N-[(1S,2S)-2- (3-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1cccc(F)c1
PDB

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n/an/an/an/a 21n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466497
PNG
(US10799507, Example 163 | [1- (cyanomethyl) cyclop...)
Show SMILES O=C(OCC1(CC#N)CC1)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 25n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466343
PNG
((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1
PDB

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n/an/an/an/a 25.4n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466356
PNG
((8S)-N-[(1S)-1-(4- cyano-3-fluoro- phenyl)ethyl]-5...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1
PDB

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n/an/an/an/a 26.8n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 27n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466487
PNG
((8S)-N-[(1S,2S)-2- hydroxy-1- methyl-2-phenyl- eth...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccccc1
PDB

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n/an/an/an/a 27.7n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466375
PNG
(5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfa...)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)cc1
PDB

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n/an/an/an/a 28.9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466491
PNG
(US10799507, Example 156 | [1-(Hydroxymethyl)Cyclop...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC1
PDB

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n/an/an/an/a 30n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466372
PNG
((8S)-N-[(1S,2S)-2- (5-fluoro-2- pyridyl)-2- hydrox...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@H](O)c1ccc(F)cn1
PDB

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n/an/an/an/a 30.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM449876
PNG
(US10703751, Example 2 | US10703751, Example 3 | tr...)
Show SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O
Show InChI InChI=1S/C17H23N5O/c1-11(23)17-21-14-10-20-16(19-2)9-15(14)22(17)13-5-3-12(4-6-13)7-8-18/h9-13,23H,3-7H2,1-2H3,(H,19,20)/t11-,12-,13-/m1/s1
PDB

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n/an/an/an/a 32n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466380
PNG
((8S)-N-[2-(5- fluoro-2-pyridyl)- 2-hydroxy-ethyl]-...)
Show SMILES OC(CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cn1
PDB

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n/an/an/an/a 32.1n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466376
PNG
((8S)-N-[(1R)-1- (2,4- difluorophenyl)-2- hydroxy-e...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1F
PDB

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n/an/an/an/a 32.9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466383
PNG
((8S)óN-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cn1
PDB

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n/an/an/an/a 33.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50261269
PNG
(CHEMBL4092191)
Show SMILES Clc1cccc(Cl)c1-c1nc2ccnc(Nc3cc(ccn3)C#N)c2[nH]1
Show InChI InChI=1S/C18H10Cl2N6/c19-11-2-1-3-12(20)15(11)17-24-13-5-7-23-18(16(13)26-17)25-14-8-10(9-21)4-6-22-14/h1-8H,(H,24,26)(H,22,23,25)
PDB

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n/an/an/an/a 35n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISA


Bioorg Med Chem Lett 27: 4370-4376 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.022
BindingDB Entry DOI: 10.7270/Q2RF5XG8
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466387
PNG
((8S)-N-[(1S,2R)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@H](O)c1ccc(F)cc1
PDB

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n/an/an/an/a 37.9n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM466394
PNG
((8S)-N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5...)
Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1
PDB

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n/an/an/an/a 38n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)

More data for this
Ligand-Target Pair
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