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Compile Data Set for Download or QSAR

Found 254 hits Enz. Inhib. hit(s) with Target = 'Non-structural protein 5A (NS5A)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243436
PNG
(US9427428, 17 | US9427428, 21)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34-,35-,36-,37-/m0/s1
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UniChem
US Patent
n/an/an/an/a 0.00300n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245924
PNG
(US9433609, 17)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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US Patent
n/an/an/an/a 0.00300n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243437
PNG
(US9427428, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34+,35-,36-,37-/m0/s1
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US Patent
n/an/an/an/a 0.00300n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245925
PNG
(US9433609, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2cc(ccc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 0.00300n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245924
PNG
(US9433609, 17)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 0.00500n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245925
PNG
(US9433609, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2cc(ccc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 0.00500n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243437
PNG
(US9427428, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34+,35-,36-,37-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 0.00500n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243436
PNG
(US9427428, 17 | US9427428, 21)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34-,35-,36-,37-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 0.00500n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241839
PNG
(US9416139, 17)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1C[C@@H](C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc(cc1)C1=C[N](=CN1)[C@@H]1C[C@H](C)CN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C54H67N8O7/c1-30(2)46(57-52(66)68-7)50(64)61-26-32(5)21-44(61)48-56-42-18-15-36(23-39(42)49(63)59-48)38-17-16-37(40-24-54(25-41(38)40)19-9-10-20-54)34-11-13-35(14-12-34)43-28-60(29-55-43)45-22-33(6)27-62(45)51(65)47(31(3)4)58-53(67)69-8/h11-18,23,28-33,44-47,55H,9-10,19-22,24-27H2,1-8H3,(H,57,66)(H,58,67)(H,56,59,63)/t32-,33-,44-,45-,46-,47-/m0/s1
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n/an/an/an/a 0.00600n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241851
PNG
(US9416139, 29)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ncc(c2CC3(CCCC3)Cc12)-c1ccc2c(c1)N=C(NS2(=O)=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C50H61N9O8S/c1-28(2)41(55-48(62)66-5)46(60)58-21-9-11-38(58)44-52-27-37(54-44)30-13-15-31(16-14-30)43-34-25-50(19-7-8-20-50)24-33(34)35(26-51-43)32-17-18-40-36(23-32)53-45(57-68(40,64)65)39-12-10-22-59(39)47(61)42(29(3)4)56-49(63)67-6/h13-18,23,26-29,38-39,41-42H,7-12,19-22,24-25H2,1-6H3,(H,52,54)(H,53,57)(H,55,62)(H,56,63)/t38-,39-,41-,42-/m0/s1
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n/an/an/an/a 0.00900n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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US Patent
n/an/an/an/a 0.0120n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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n/an/an/an/a 0.0120n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245918
PNG
(US9433609, 2 | US9433609, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C38H46N8O7/c1-21(2)31(43-37(49)52-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)51-4)44-38(50)53-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t22-,29+,30+,31+,32+/m1/s1
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n/an/an/an/a 0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241836
PNG
(US9416139, 14)
Show SMILES COC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)OC
Show InChI InChI=1S/C48H52N8O7/c1-27(50-46(60)62-3)44(58)55-21-7-9-39(55)41-49-26-38(53-41)30-13-11-29(12-14-30)32-16-17-33(36-25-48(24-35(32)36)19-5-6-20-48)31-15-18-37-34(23-31)43(57)54-42(52-37)40-10-8-22-56(40)45(59)28(2)51-47(61)63-4/h11-18,23,26-28,39-40H,5-10,19-22,24-25H2,1-4H3,(H,50,60)(H,51,61)/b32-29-,33-31+,38-30-/t27-,28-,39-,40-/m0/s1
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n/an/an/an/a 0.0130n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243438
PNG
(US9427428, 11)
Show SMILES CO[C@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33-,34+,35-,36-/m1/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243435
PNG
(US9427428, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C42H48N8O8/c1-23(55-3)35(47-41(53)57-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(2)56-4)48-42(54)58-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t23-,24-,33+,34+,35+,36+/m1/s1
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n/an/an/an/a 0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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n/an/an/an/a 0.0160n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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n/an/an/an/a 0.0160n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241826
PNG
(US9416139, 4)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2c(c1)N=C(NC21COC1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C54H66N8O7/c1-31(2)45(58-51(65)67-5)49(63)61-23-9-11-43(61)47-55-28-42(57-47)34-15-13-33(14-16-34)36-18-19-37(39-27-53(26-38(36)39)21-7-8-22-53)35-17-20-40-41(25-35)56-48(60-54(40)29-69-30-54)44-12-10-24-62(44)50(64)46(32(3)4)59-52(66)68-6/h13-20,25,28,31-32,43-46H,7-12,21-24,26-27,29-30H2,1-6H3,(H,55,57)(H,56,60)(H,58,65)(H,59,66)/t43-,44-,45-,46-/m0/s1
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n/an/an/an/a 0.0160n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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n/an/an/an/a<0.0170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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n/an/an/an/a<0.0170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243435
PNG
(US9427428, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C42H48N8O8/c1-23(55-3)35(47-41(53)57-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(2)56-4)48-42(54)58-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t23-,24-,33+,34+,35+,36+/m1/s1
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n/an/an/an/a 0.0200n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245918
PNG
(US9433609, 2 | US9433609, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C38H46N8O7/c1-21(2)31(43-37(49)52-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)51-4)44-38(50)53-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t22-,29+,30+,31+,32+/m1/s1
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n/an/an/an/a 0.0200n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
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n/an/an/an/a 0.0210n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243438
PNG
(US9427428, 11)
Show SMILES CO[C@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33-,34+,35-,36-/m1/s1
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n/an/an/an/a 0.0210n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241855
PNG
(US9416139, 33)
Show SMILES COC(=O)NC(C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(nc1)-c1cc(F)c(c2CC3(CCCC3)Cc12)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C51H58FN9O7/c1-27(2)42(57-49(65)67-5)47(63)60-19-9-11-39(60)44-54-26-38(56-44)30-14-15-36(53-25-30)31-22-35(52)41(34-24-51(23-33(31)34)17-7-8-18-51)29-13-16-37-32(21-29)46(62)59-45(55-37)40-12-10-20-61(40)48(64)43(28(3)4)58-50(66)68-6/h13-16,21-22,25-28,39-40,42-43H,7-12,17-20,23-24H2,1-6H3,(H,57,65)(H,58,66)/b36-31-,38-30+,41-29-/t39-,40-,42?,43-/m0/s1
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n/an/an/an/a 0.0220n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1a (HCV))
BDBM241839
PNG
(US9416139, 17)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1C[C@@H](C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc(cc1)C1=C[N](=CN1)[C@@H]1C[C@H](C)CN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C54H67N8O7/c1-30(2)46(57-52(66)68-7)50(64)61-26-32(5)21-44(61)48-56-42-18-15-36(23-39(42)49(63)59-48)38-17-16-37(40-24-54(25-41(38)40)19-9-10-20-54)34-11-13-35(14-12-34)43-28-60(29-55-43)45-22-33(6)27-62(45)51(65)47(31(3)4)58-53(67)69-8/h11-18,23,28-33,44-47,55H,9-10,19-22,24-27H2,1-8H3,(H,57,66)(H,58,67)(H,56,59,63)/t32-,33-,44-,45-,46-,47-/m0/s1
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n/an/an/an/a 0.0230n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241827
PNG
(US9416139, 5)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2c(c1)N=C(NS2(=O)=O)C1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C51H62N8O8S/c1-29(2)43(55-49(62)66-5)47(60)58-23-9-11-40(58)45-52-28-39(54-45)32-15-13-31(14-16-32)34-18-19-35(37-27-51(26-36(34)37)21-7-8-22-51)33-17-20-42-38(25-33)53-46(57-68(42,64)65)41-12-10-24-59(41)48(61)44(30(3)4)56-50(63)67-6/h13-20,25,28-30,40-41,43-44H,7-12,21-24,26-27H2,1-6H3,(H,52,54)(H,53,57)(H,55,62)(H,56,63)/t40-,41?,43-,44-/m0/s1
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n/an/an/an/a 0.0230n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Serine protease NS5A (L31M)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243436
PNG
(US9427428, 17 | US9427428, 21)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0250n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31M)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245924
PNG
(US9433609, 17)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0250n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (R30H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0270n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (R30H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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PC sid
UniChem
US Patent
n/an/an/an/a 0.0270n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241843
PNG
(US9416139, 21)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CC2(CC2)CN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C56H64N8O7/c1-31(2)45(60-52(68)70-5)50(66)63-29-55(19-20-55)26-43(63)47-57-28-42(59-47)34-11-9-33(10-12-34)36-14-15-37(40-25-54(24-39(36)40)17-7-8-18-54)35-13-16-41-38(23-35)49(65)62-48(58-41)44-27-56(21-22-56)30-64(44)51(67)46(32(3)4)61-53(69)71-6/h9-16,23,28,31-32,43-46H,7-8,17-22,24-27,29-30H2,1-6H3,(H,60,68)(H,61,69)/b36-33-,37-35-,42-34+/t43-,44-,45-,46-/m0/s1
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UniChem
US Patent
n/an/an/an/a 0.0290n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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US Patent
n/an/an/an/a 0.0320n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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PC sid
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US Patent
n/an/an/an/a 0.0320n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Non-structural protein 5A (NS5A)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM241832
PNG
(US9416139, 10 | US9416139, 11)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(Cc12)CCN(C)CC3)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CC2CC2N1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C54H63N9O7/c1-29(2)45(58-52(67)69-6)50(65)62-20-8-9-42(62)47-55-28-41(57-47)32-12-10-31(11-13-32)35-15-16-36(39-27-54(26-38(35)39)18-21-61(5)22-19-54)33-14-17-40-37(23-33)49(64)60-48(56-40)44-25-34-24-43(34)63(44)51(66)46(30(3)4)59-53(68)70-7/h10-17,23,28-30,34,42-46H,8-9,18-22,24-27H2,1-7H3,(H,58,67)(H,59,68)/b35-31-,36-33-,41-32-/t34?,42-,43?,44-,45-,46-/m0/s1
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US Patent
n/an/an/an/a 0.0320n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The Huh-7 cells transfected with HCV replicons system were seeded into 96-well plates (8,000 cells in 125 μL/well) respectively; each test compoun...


US Patent US9416139 (2016)


BindingDB Entry DOI: 10.7270/Q2Q81C0T
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243436
PNG
(US9427428, 17 | US9427428, 21)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34-,35-,36-,37-/m0/s1
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US Patent
n/an/an/an/a 0.0340n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
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