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Compile Data Set for Download or QSAR

Found 143 hits Enz. Inhib. hit(s) with Target = 'Norovirus Polymerase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Norovirus Polymerase


(Murine norovirus 1)
BDBM263074
PNG
(US9708359, 3)
Show SMILES C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C16H22N6O6/c1-5(17)16(26)27-4-8-10(23)11(24)15(28-8)22-3-7(13(19)25)9-12(18)20-6(2)21-14(9)22/h3,5,8,10-11,15,23-24H,4,17H2,1-2H3,(H2,19,25)(H2,18,20,21)/t5-,8+,10+,11+,15+/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263076
PNG
(US9708359, 5)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COC(=O)[C@@H](N)Cc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C22H26N6O6/c1-10-26-18(24)15-12(19(25)31)8-28(20(15)27-10)21-17(30)16(29)14(34-21)9-33-22(32)13(23)7-11-5-3-2-4-6-11/h2-6,8,13-14,16-17,21,29-30H,7,9,23H2,1H3,(H2,25,31)(H2,24,26,27)/t13-,14+,16+,17+,21+/m0/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263086
PNG
(US9708359, 139)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C41H65N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-24-53-25-21-26-54-41(51)29(2)46-58(52,57-31-22-18-17-19-23-31)55-28-33-35(48)36(49)40(56-33)47-27-32(38(43)50)34-37(42)44-30(3)45-39(34)47/h17-19,22-23,27,29,33,35-36,40,48-49H,4-16,20-21,24-26,28H2,1-3H3,(H2,43,50)(H,46,52)(H2,42,44,45)/t29-,33+,35+,36+,40+,58?/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 2.65E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263073
PNG
(US9708359, 2)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C18H26N6O6/c1-6(2)11(19)18(28)29-5-9-12(25)13(26)17(30-9)24-4-8(15(21)27)10-14(20)22-7(3)23-16(10)24/h4,6,9,11-13,17,25-26H,5,19H2,1-3H3,(H2,21,27)(H2,20,22,23)/t9-,11+,12-,13-,17-/m1/s1
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n/an/an/an/a 3.03E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 3.08E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263078
PNG
(US9708359, 71)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N5O8P/c1-4-16-10(14)7-5(11(15)21)2-18(12(7)17-4)13-9(20)8(19)6(26-13)3-25-27(22,23)24/h2,6,8-9,13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 3.15E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263087
PNG
(US9708359, 141)
Show SMILES CC(C)OC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H29N6O9P/c1-7(2)33-19(29)8(3)24-35(30,31)32-6-11-13(26)14(27)18(34-11)25-5-10(16(21)28)12-15(20)22-9(4)23-17(12)25/h5,7-8,11,13-14,18,26-27H,6H2,1-4H3,(H2,21,28)(H2,20,22,23)(H2,24,30,31)/t8-,11+,13+,14+,18+/m0/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263075
PNG
(US9708359, 4)
Show SMILES CCCCCCCCCCCCCCCCOCCC(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C32H53N5O7/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-42-19-17-25(38)43-21-24-27(39)28(40)32(44-24)37-20-23(30(34)41)26-29(33)35-22(2)36-31(26)37/h20,24,27-28,32,39-40H,3-19,21H2,1-2H3,(H2,34,41)(H2,33,35,36)/t24-,27-,28-,32-/m1/s1
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n/an/an/an/a 3.50E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263079
PNG
(US9708359, 77)
Show SMILES CC(C)C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H28N6O6/c1-7(2)4-10(20)19(29)30-6-11-13(26)14(27)18(31-11)25-5-9(16(22)28)12-15(21)23-8(3)24-17(12)25/h5,7,10-11,13-14,18,26-27H,4,6,20H2,1-3H3,(H2,22,28)(H2,21,23,24)/t10-,11+,13+,14+,18+/m0/s1
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n/an/an/an/a 4.40E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263212
PNG
(US9708359, 127)
Show SMILES CN(C)\C=N\c1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C16H22N6O5/c1-7-19-14(18-6-21(2)3)10-8(13(17)26)4-22(15(10)20-7)16-12(25)11(24)9(5-23)27-16/h4,6,9,11-12,16,23-25H,5H2,1-3H3,(H2,17,26)/b18-6+/t9-,11-,12-,16-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263089
PNG
(US9708359, 145)
Show SMILES CCCCCCCCC(=O)Oc1ccc(COP(=O)(OCc2ccc(OC(=O)CCCCCCCC)cc2)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cc(C(N)=O)c3c(N)nc(C)nc23)cc1
Show InChI InChI=1S/C45H63N5O15P2/c1-4-6-8-10-12-14-16-37(51)62-33-22-18-31(19-23-33)27-60-67(58,61-28-32-20-24-34(25-21-32)63-38(52)17-15-13-11-9-7-5-2)65-66(56,57)59-29-36-40(53)41(54)45(64-36)50-26-35(43(47)55)39-42(46)48-30(3)49-44(39)50/h18-26,36,40-41,45,53-54H,4-17,27-29H2,1-3H3,(H2,47,55)(H,56,57)(H2,46,48,49)/t36-,40-,41-,45-/m1/s1
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n/an/an/an/a 7.40E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263080
PNG
(US9708359, 76)
Show SMILES CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C34H38N6O8/c1-16(2)12-24(39-34(45)47-14-23-20-10-6-4-8-18(20)19-9-5-7-11-21(19)23)33(44)46-15-25-27(41)28(42)32(48-25)40-13-22(30(36)43)26-29(35)37-17(3)38-31(26)40/h4-11,13,16,23-25,27-28,32,41-42H,12,14-15H2,1-3H3,(H2,36,43)(H,39,45)(H2,35,37,38)/t24-,25+,27+,28+,32+/m0/s1
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n/an/an/an/a 1.64E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263081
PNG
(US9708359, 107)
Show SMILES C[C@H](NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H33N6O9P/c1-16(29(39)41-14-18-9-5-3-6-10-18)34-45(40,44-19-11-7-4-8-12-19)42-15-21-23(36)24(37)28(43-21)35-13-20(26(31)38)22-25(30)32-17(2)33-27(22)35/h3-13,16,21,23-24,28,36-37H,14-15H2,1-2H3,(H2,31,38)(H,34,40)(H2,30,32,33)/t16-,21+,23+,24+,28+,45?/m0/s1
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n/an/an/an/a 1.81E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263085
PNG
(US9708359, 137)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCc1ccccc1C
Show InChI InChI=1S/C27H37N6O9P/c1-13(2)41-27(37)15(4)32-43(38,39-11-17-9-7-6-8-14(17)3)40-12-19-21(34)22(35)26(42-19)33-10-18(24(29)36)20-23(28)30-16(5)31-25(20)33/h6-10,13,15,19,21-22,26,34-35H,11-12H2,1-5H3,(H2,29,36)(H,32,38)(H2,28,30,31)/t15-,19+,21+,22+,26+,43?/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263179
PNG
(US9708359, 24)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C33H58N5O9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-44-19-17-20-46-48(42,43)23-45-22-26-28(39)29(40)33(47-26)38-21-25(31(35)41)27-30(34)36-24(2)37-32(27)38/h21,26,28-29,33,39-40H,3-20,22-23H2,1-2H3,(H2,35,41)(H,42,43)(H2,34,36,37)/t26-,28-,29-,33-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263099
PNG
(US9708359, 20)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@H]4OC(C)(C)O[C@@H]34)c2n1)C(N)=O
Show InChI InChI=1S/C16H21N5O5/c1-6-19-12(17)9-7(13(18)23)4-21(14(9)20-6)15-11-10(8(5-22)24-15)25-16(2,3)26-11/h4,8,10-11,15,22H,5H2,1-3H3,(H2,18,23)(H2,17,19,20)/t8-,10-,11-,15-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263130
PNG
(US9708359, 66)
Show SMILES COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C27H29N5O7/c1-12(14-4-5-16-9-17(37-3)7-6-15(16)8-14)27(36)38-11-19-21(33)22(34)26(39-19)32-10-18(24(29)35)20-23(28)30-13(2)31-25(20)32/h4-10,12,19,21-22,26,33-34H,11H2,1-3H3,(H2,29,35)(H2,28,30,31)/t12-,19-,21-,22-,26-/m1/s1
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n/an/an/an/a 2.02E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263082
PNG
(US9708359, 111)
Show SMILES COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C23H29N6O9P/c1-11(23(33)35-3)28-39(34,38-13-7-5-4-6-8-13)36-10-15-17(30)18(31)22(37-15)29-9-14(20(25)32)16-19(24)26-12(2)27-21(16)29/h4-9,11,15,17-18,22,30-31H,10H2,1-3H3,(H2,25,32)(H,28,34)(H2,24,26,27)/t11-,15+,17+,18+,22+,39?/m0/s1
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n/an/an/an/a 2.10E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263091
PNG
(US9708359, 8)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2[n+]1[O-])C(N)=O
Show InChI InChI=1S/C13H17N5O6/c1-4-16-10(14)7-5(11(15)22)2-17(12(7)18(4)23)13-9(21)8(20)6(3-19)24-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,14,16)(H2,15,22)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 2.36E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263084
PNG
(US9708359, 133)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C33H45N6O11P/c1-16(2)31(41)48-25-23(15-45-51(44,50-21-12-10-9-11-13-21)38-19(7)33(43)46-18(5)6)47-30(26(25)49-32(42)17(3)4)39-14-22(28(35)40)24-27(34)36-20(8)37-29(24)39/h9-14,16-19,23,25-26,30H,15H2,1-8H3,(H2,35,40)(H,38,44)(H2,34,36,37)/t19-,23+,25+,26+,30+,51?/m0/s1
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n/an/an/an/a 2.57E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263088
PNG
(US9708359, 143)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C35H61N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-48-20-18-21-49-35(45)24(2)40-52(46,47)50-23-27-29(42)30(43)34(51-27)41-22-26(32(37)44)28-31(36)38-25(3)39-33(28)41/h22,24,27,29-30,34,42-43H,4-21,23H2,1-3H3,(H2,37,44)(H2,36,38,39)(H2,40,46,47)/t24-,27+,29+,30+,34+/m0/s1
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n/an/an/an/a 2.63E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/m1/s1
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n/an/an/an/a 3.36E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/m1/s1
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n/an/an/an/a 3.89E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263166
PNG
(US9708359, 130)
Show SMILES CCCCCCCCCCCCCCCCOCCCC(=O)Nc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C33H55N5O7/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-44-20-17-18-26(40)37-31-27-24(30(34)43)21-38(32(27)36-23(2)35-31)33-29(42)28(41)25(22-39)45-33/h21,25,28-29,33,39,41-42H,3-20,22H2,1-2H3,(H2,34,43)(H,35,36,37,40)/t25-,28-,29-,33-/m1/s1
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n/an/an/an/a 4.27E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263175
PNG
(US9708359, 9)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9+,13-/m1/s1
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n/an/an/an/a 5.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263090
PNG
(US9708359, 7)
Show SMILES Cc1nc(O)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N4O6/c1-4-15-11-7(12(22)16-4)5(10(14)21)2-17(11)13-9(20)8(19)6(3-18)23-13/h2,6,8-9,13,18-20H,3H2,1H3,(H2,14,21)(H,15,16,22)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 5.38E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263092
PNG
(US9708359, 10)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)-c1nn[nH]n1
Show InChI InChI=1S/C13H16N8O4/c1-4-15-10(14)7-5(11-17-19-20-18-11)2-21(12(7)16-4)13-9(24)8(23)6(3-22)25-13/h2,6,8-9,13,22-24H,3H2,1H3,(H2,14,15,16)(H,17,18,19,20)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 6.15E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263170
PNG
(US9708359, 136)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(=O)(NCc4ccccc4)NCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C27H32N7O6P/c1-16-32-24(28)21-19(25(29)37)14-34(26(21)33-16)27-23(36)22(35)20(40-27)15-39-41(38,30-12-17-8-4-2-5-9-17)31-13-18-10-6-3-7-11-18/h2-11,14,20,22-23,27,35-36H,12-13,15H2,1H3,(H2,29,37)(H2,28,32,33)(H2,30,31,38)/t20-,22-,23-,27-/m1/s1
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n/an/an/an/a 6.45E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263169
PNG
(US9708359, 134)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@@H]2OC(=O)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C26H31N6O10P/c1-12(2)38-25(34)13(3)31-43(36,42-15-8-6-5-7-9-15)37-11-17-19-20(41-26(35)40-19)24(39-17)32-10-16(22(28)33)18-21(27)29-14(4)30-23(18)32/h5-10,12-13,17,19-20,24H,11H2,1-4H3,(H2,28,33)(H,31,36)(H2,27,29,30)/t13-,17+,19+,20+,24+,43?/m0/s1
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n/an/an/an/a 6.84E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263130
PNG
(US9708359, 66)
Show SMILES COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C27H29N5O7/c1-12(14-4-5-16-9-17(37-3)7-6-15(16)8-14)27(36)38-11-19-21(33)22(34)26(39-19)32-10-18(24(29)35)20-23(28)30-13(2)31-25(20)32/h4-10,12,19,21-22,26,33-34H,11H2,1-3H3,(H2,29,35)(H2,28,30,31)/t12-,19-,21-,22-,26-/m1/s1
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n/an/an/an/a 7.18E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263185
PNG
(US9708359, 56)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](CO)Cn1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C31H56N5O7P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-41-19-17-20-43-44(39,40)24-42-26(23-37)21-36-22-27(30(33)38)28-29(32)34-25(2)35-31(28)36/h22,26,37H,3-21,23-24H2,1-2H3,(H2,33,38)(H,39,40)(H2,32,34,35)/t26-/m0/s1
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n/an/an/an/a 7.53E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263165
PNG
(US9708359, 129)
Show SMILES CC(=O)OC[C@H]1O[C@H]([C@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H23N5O8/c1-7-22-16(20)13-11(17(21)28)5-24(18(13)23-7)19-15(31-10(4)27)14(30-9(3)26)12(32-19)6-29-8(2)25/h5,12,14-15,19H,6H2,1-4H3,(H2,21,28)(H2,20,22,23)/t12-,14-,15-,19-/m1/s1
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n/an/an/an/a 8.87E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263161
PNG
(US9708359, 123)
Show SMILES CCOP(=O)(CCO[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#N)c2c(Cl)nc(C)nc12)OCC
Show InChI InChI=1S/C18H24ClN4O7P/c1-4-28-31(26,29-5-2)7-6-27-18-14(25)13(24)17(30-18)23-9-11(8-20)12-15(19)21-10(3)22-16(12)23/h9,13-14,17-18,24-25H,4-7H2,1-3H3/t13-,14+,17-,18+/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263162
PNG
(US9708359, 124)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](O)C=C3)c2n1)C(N)=O
Show InChI InChI=1S/C12H13N5O3/c1-5-15-10(13)9-6(11(14)19)4-17(12(9)16-5)7-2-3-8(18)20-7/h2-4,7-8,18H,1H3,(H2,14,19)(H2,13,15,16)/t7-,8+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263163
PNG
(US9708359, 125)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](OCCP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H20N5O8P/c1-5-17-10(15)7-6(11(16)22)4-19(12(7)18-5)13-8(20)9(21)14(27-13)26-2-3-28(23,24)25/h4,8-9,13-14,20-21H,2-3H2,1H3,(H2,16,22)(H2,15,17,18)(H2,23,24,25)/t8-,9+,13-,14+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263164
PNG
(US9708359, 128)
Show SMILES CC(=O)Nc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
Show InChI InChI=1S/C21H25N5O9/c1-8-23-19(25-9(2)27)15-13(18(22)31)6-26(20(15)24-8)21-17(34-12(5)30)16(33-11(4)29)14(35-21)7-32-10(3)28/h6,14,16-17,21H,7H2,1-5H3,(H2,22,31)(H,23,24,25,27)/t14-,16-,17-,21-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263167
PNG
(US9708359, 131)
Show SMILES CCCC(CCC)C(=O)Nc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H31N5O6/c1-4-6-11(7-5-2)20(31)25-18-14-12(17(22)30)8-26(19(14)24-10(3)23-18)21-16(29)15(28)13(9-27)32-21/h8,11,13,15-16,21,27-29H,4-7,9H2,1-3H3,(H2,22,30)(H,23,24,25,31)/t13-,15-,16-,21-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263168
PNG
(US9708359, 132)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C25H33N6O9P/c1-12(2)38-25(35)13(3)30-41(36,40-15-8-6-5-7-9-15)37-11-17-19(32)20(33)24(39-17)31-10-16(22(27)34)18-21(26)28-14(4)29-23(18)31/h5-10,12-13,17,19-20,24,32-33H,11H2,1-4H3,(H2,27,34)(H,30,36)(H2,26,28,29)/t13-,17+,19+,20+,24+,41?/m0/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263171
PNG
(US9708359, 138)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@@H]4CCP(O)(=O)O[C@H]4[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H18N5O6P/c1-5-17-11(15)8-6(12(16)21)4-19(13(8)18-5)14-9(20)10-7(24-14)2-3-26(22,23)25-10/h4,7,9-10,14,20H,2-3H2,1H3,(H2,16,21)(H,22,23)(H2,15,17,18)/t7-,9-,10-,14-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263172
PNG
(US9708359, 140)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(=O)(N[C@@H](C)C(=O)OC(C)C)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C38H67N6O10P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-50-22-20-23-51-55(49,43-27(4)38(48)53-26(2)3)52-25-30-32(45)33(46)37(54-30)44-24-29(35(40)47)31-34(39)41-28(5)42-36(31)44/h24,26-27,30,32-33,37,45-46H,6-23,25H2,1-5H3,(H2,40,47)(H,43,49)(H2,39,41,42)/t27-,30+,32+,33+,37+,55?/m0/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263173
PNG
(US9708359, 142)
Show SMILES CCCCCCCCCCCCCCCOCCCOC(=O)C(C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCc1ccccc1C
Show InChI InChI=1S/C42H67N6O10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-19-23-54-24-20-25-55-42(52)30(3)47-59(53,56-27-32-22-18-17-21-29(32)2)57-28-34-36(49)37(50)41(58-34)48-26-33(39(44)51)35-38(43)45-31(4)46-40(35)48/h17-18,21-22,26,30,34,36-37,41,49-50H,5-16,19-20,23-25,27-28H2,1-4H3,(H2,44,51)(H,47,53)(H2,43,45,46)/t30?,34-,36-,37-,41-,59?/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263174
PNG
(US9708359, 144)
Show SMILES Cc1nc(N)c2c(C(N)=O)c(C=C)n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H19N5O5/c1-3-6-8(13(17)24)9-12(16)18-5(2)19-14(9)20(6)15-11(23)10(22)7(4-21)25-15/h3,7,10-11,15,21-23H,1,4H2,2H3,(H2,17,24)(H2,16,18,19)/t7-,10-,11-,15-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263177
PNG
(US9708359, 15)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C18H19N5O5/c19-14-11-9(15(20)27)6-23(18-13(26)12(25)10(7-24)28-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,27)(H2,19,21,22)/t10-,12-,13-,18-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263178
PNG
(US9708359, 23)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C14H20N5O8P/c1-5-17-11(15)8-6(12(16)22)2-19(13(8)18-5)14-10(21)9(20)7(27-14)3-26-4-28(23,24)25/h2,7,9-10,14,20-21H,3-4H2,1H3,(H2,16,22)(H2,15,17,18)(H2,23,24,25)/t7-,9-,10-,14-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263180
PNG
(US9708359, 25)
Show SMILES CCOP(=O)(COC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C18H28N5O8P/c1-4-29-32(27,30-5-2)8-28-7-11-13(24)14(25)18(31-11)23-6-10(16(20)26)12-15(19)21-9(3)22-17(12)23/h6,11,13-14,18,24-25H,4-5,7-8H2,1-3H3,(H2,20,26)(H2,19,21,22)/t11-,13-,14-,18-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263181
PNG
(US9708359, 26 | US9708359, 80)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)C(F)(F)F
Show InChI InChI=1S/C13H14F3N5O5/c14-13(15,16)12-19-8(17)5-3(9(18)25)1-21(10(5)20-12)11-7(24)6(23)4(2-22)26-11/h1,4,6-7,11,22-24H,2H2,(H2,18,25)(H2,17,19,20)/t4-,6-,7-,11-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263182
PNG
(US9708359, 40)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)C3(F)F)c2n1)C(N)=O
Show InChI InChI=1S/C13H15F2N5O4/c1-4-18-9(16)7-5(10(17)23)2-20(11(7)19-4)12-13(14,15)8(22)6(3-21)24-12/h2,6,8,12,21-22H,3H2,1H3,(H2,17,23)(H2,16,18,19)/t6-,8-,12-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263183
PNG
(US9708359, 52)
Show SMILES Cc1nc(N)c2c(cn(C[C@@H](CO)OCP(O)(O)=O)c2n1)C(N)=O
Show InChI InChI=1S/C12H18N5O6P/c1-6-15-10(13)9-8(11(14)19)3-17(12(9)16-6)2-7(4-18)23-5-24(20,21)22/h3,7,18H,2,4-5H2,1H3,(H2,14,19)(H2,13,15,16)(H2,20,21,22)/t7-/m0/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)

More data for this
Ligand-Target Pair
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