BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3823 hits Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446453
PNG
((R)-1-((7-cyano-2-(3′-(7-(((R)-3-hydroxypyrr...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@H](C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@H](O)C3)cc2n1
Show InChI InChI=1S/C41H40N8O4/c1-23-31(6-4-8-33(23)40-47-36-15-26(14-29(17-42)38(36)53-40)19-48-12-10-28(21-48)41(51)52)32-7-5-9-34(24(32)2)46-39-37-35(44-25(3)45-39)16-27(18-43-37)20-49-13-11-30(50)22-49/h4-9,14-16,18,28,30,50H,10-13,19-22H2,1-3H3,(H,51,52)(H,44,45,46)/t28-,30-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446473
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES CNC(=O)C1CCN(Cc2cc(C#N)c3oc(nc3c2)-c2cccc(c2C)-c2cccc(Nc3nc(nc4cc(CN5CC[C@@H](O)C5)cnc34)C(F)F)c2C)CC1
Show InChI InChI=1S/C43H43F2N9O3/c1-24-31(6-4-8-33(24)43-51-36-17-26(16-29(19-46)38(36)57-43)21-53-13-10-28(11-14-53)42(56)47-3)32-7-5-9-34(25(32)2)49-40-37-35(50-41(52-40)39(44)45)18-27(20-48-37)22-54-15-12-30(55)23-54/h4-9,16-18,20,28,30,39,55H,10-15,21-23H2,1-3H3,(H,47,56)(H,49,50,52)/t30-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446478
PNG
((S)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@](C)(O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-29(19-46)37(35)57-41)21-52-13-10-28(11-14-52)42(54)55)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-15-12-43(3,56)23-53/h4-9,16-18,20,28,38,56H,10-15,21-23H2,1-3H3,(H,54,55)(H,48,49,51)/t43-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446477
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@](C)(O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-29(19-46)37(35)57-41)21-52-13-10-28(11-14-52)42(54)55)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-15-12-43(3,56)23-53/h4-9,16-18,20,28,38,56H,10-15,21-23H2,1-3H3,(H,54,55)(H,48,49,51)/t43-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446463
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C42H40F2N8O4/c1-23-30(5-3-7-32(23)41-49-35-16-25(15-28(18-45)37(35)56-41)20-51-12-9-27(10-13-51)42(54)55)31-6-4-8-33(24(31)2)47-39-36-34(48-40(50-39)38(43)44)17-26(19-46-36)21-52-14-11-29(53)22-52/h3-8,15-17,19,27,29,38,53H,9-14,20-22H2,1-2H3,(H,54,55)(H,47,48,50)/t29-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446481
PNG
((R)-1-((7-cyano-2-(3′-(6-(difluoromethyl)-3-...)
Show SMILES Cc1c(Nc2nc(cc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C43H41F2N7O4/c1-24-31(6-4-8-33(24)41-50-35-16-26(14-29(18-46)38(35)56-41)20-52-13-11-43(3,23-52)42(54)55)32-7-5-9-34(25(32)2)48-40-37-28(17-36(49-40)39(44)45)15-27(19-47-37)21-51-12-10-30(53)22-51/h4-9,14-17,19,30,39,53H,10-13,20-23H2,1-3H3,(H,48,49)(H,54,55)/t30-,43-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446470
PNG
((S)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C42H40F2N8O4/c1-23-29(6-4-8-31(23)40-49-34-15-25(14-27(17-45)36(34)56-40)19-52-13-11-42(3,22-52)41(54)55)30-7-5-9-32(24(30)2)47-38-35-33(48-39(50-38)37(43)44)16-26(18-46-35)20-51-12-10-28(53)21-51/h4-9,14-16,18,28,37,53H,10-13,19-22H2,1-3H3,(H,54,55)(H,47,48,50)/t28-,42+/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446465
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C42H40F2N8O4/c1-23-29(6-4-8-31(23)40-49-34-15-25(14-27(17-45)36(34)56-40)19-52-13-11-42(3,22-52)41(54)55)30-7-5-9-32(24(30)2)47-38-35-33(48-39(50-38)37(43)44)16-26(18-46-35)20-51-12-10-28(53)21-51/h4-9,14-16,18,28,37,53H,10-13,19-22H2,1-3H3,(H,54,55)(H,47,48,50)/t28-,42-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446463
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C42H40F2N8O4/c1-23-30(5-3-7-32(23)41-49-35-16-25(15-28(18-45)37(35)56-41)20-51-12-9-27(10-13-51)42(54)55)31-6-4-8-33(24(31)2)47-39-36-34(48-40(50-39)38(43)44)17-26(19-46-36)21-52-14-11-29(53)22-52/h3-8,15-17,19,27,29,38,53H,9-14,20-22H2,1-2H3,(H,54,55)(H,47,48,50)/t29-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446464
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C41H38F2N8O4/c1-22-29(5-3-7-31(22)40-48-34-14-24(13-27(16-44)36(34)55-40)18-50-11-9-26(20-50)41(53)54)30-6-4-8-32(23(30)2)46-38-35-33(47-39(49-38)37(42)43)15-25(17-45-35)19-51-12-10-28(52)21-51/h3-8,13-15,17,26,28,37,52H,9-12,18-21H2,1-2H3,(H,53,54)(H,46,47,49)/t26-,28-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446465
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C42H40F2N8O4/c1-23-29(6-4-8-31(23)40-49-34-15-25(14-27(17-45)36(34)56-40)19-52-13-11-42(3,22-52)41(54)55)30-7-5-9-32(24(30)2)47-38-35-33(48-39(50-38)37(43)44)16-26(18-46-35)20-51-12-10-28(53)21-51/h4-9,14-16,18,28,37,53H,10-13,19-22H2,1-3H3,(H,54,55)(H,47,48,50)/t28-,42-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446469
PNG
((S)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@@H](C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C41H38F2N8O4/c1-22-29(5-3-7-31(22)40-48-34-14-24(13-27(16-44)36(34)55-40)18-50-11-9-26(20-50)41(53)54)30-6-4-8-32(23(30)2)46-38-35-33(47-39(49-38)37(42)43)15-25(17-45-35)19-51-12-10-28(52)21-51/h3-8,13-15,17,26,28,37,52H,9-12,18-21H2,1-2H3,(H,53,54)(H,46,47,49)/t26-,28+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446471
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(C)(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-28(19-46)37(35)57-41)21-52-14-11-43(3,12-15-52)42(55)56)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-13-10-29(54)23-53/h4-9,16-18,20,29,38,54H,10-15,21-23H2,1-3H3,(H,55,56)(H,48,49,51)/t29-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446472
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES CN(C)C(=O)C1CCN(Cc2cc(C#N)c3oc(nc3c2)-c2cccc(c2C)-c2cccc(Nc3nc(nc4cc(CN5CC[C@@H](O)C5)cnc34)C(F)F)c2C)CC1
Show InChI InChI=1S/C44H45F2N9O3/c1-25-32(7-5-9-34(25)43-51-37-18-27(17-30(20-47)39(37)58-43)22-54-14-11-29(12-15-54)44(57)53(3)4)33-8-6-10-35(26(33)2)49-41-38-36(50-42(52-41)40(45)46)19-28(21-48-38)23-55-16-13-31(56)24-55/h5-10,17-19,21,29,31,40,56H,11-16,22-24H2,1-4H3,(H,49,50,52)/t31-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446474
PNG
((R)-3-(1-((7-cyano-2-(3′-(2-(difluoromethyl)...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(=O)NCCC(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C45H45F2N9O5/c1-25-32(33-6-4-8-35(26(33)2)51-42-39-36(52-43(54-42)41(46)47)19-28(21-50-39)23-56-16-12-31(57)24-56)5-3-7-34(25)45-53-37-18-27(17-30(20-48)40(37)61-45)22-55-14-10-29(11-15-55)44(60)49-13-9-38(58)59/h3-8,17-19,21,29,31,41,57H,9-16,22-24H2,1-2H3,(H,49,60)(H,58,59)(H,51,52,54)/t31-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446475
PNG
((R)-1-((7-cyano-2-(3′-(2-cyclopropyl-7-(((R)...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C2CC2)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C43H42N8O4/c1-24-32(5-3-7-34(24)42-48-37-16-26(15-30(18-44)39(37)55-42)20-50-13-11-29(22-50)43(53)54)33-6-4-8-35(25(33)2)46-41-38-36(47-40(49-41)28-9-10-28)17-27(19-45-38)21-51-14-12-31(52)23-51/h3-8,15-17,19,28-29,31,52H,9-14,20-23H2,1-2H3,(H,53,54)(H,46,47,49)/t29-,31-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446476
PNG
((R)-1-((2-(3′-(2-amino-7-((3-hydroxypyrrolid...)
Show SMILES Cc1c(Nc2nc(N)nc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C41H41N9O4/c1-23-30(5-3-7-32(23)39-46-35-16-25(15-28(18-42)37(35)54-39)20-49-12-9-27(10-13-49)40(52)53)31-6-4-8-33(24(31)2)45-38-36-34(47-41(43)48-38)17-26(19-44-36)21-50-14-11-29(51)22-50/h3-8,15-17,19,27,29,51H,9-14,20-22H2,1-2H3,(H,52,53)(H3,43,45,47,48)/t29-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446479
PNG
((R)-1-((7-cyano-2-(3′-(2-(hydroxymethyl)-7-(...)
Show SMILES Cc1c(Nc2nc(CO)nc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C42H42N8O5/c1-24-31(5-3-7-33(24)41-47-36-16-26(15-29(18-43)39(36)55-41)20-49-12-9-28(10-13-49)42(53)54)32-6-4-8-34(25(32)2)46-40-38-35(45-37(23-51)48-40)17-27(19-44-38)21-50-14-11-30(52)22-50/h3-8,15-17,19,28,30,51-52H,9-14,20-23H2,1-2H3,(H,53,54)(H,45,46,48)/t30-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446464
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C
Show InChI InChI=1S/C41H38F2N8O4/c1-22-29(5-3-7-31(22)40-48-34-14-24(13-27(16-44)36(34)55-40)18-50-11-9-26(20-50)41(53)54)30-6-4-8-32(23(30)2)46-38-35-33(47-39(49-38)37(42)43)15-25(17-45-35)19-51-12-10-28(52)21-51/h3-8,13-15,17,26,28,37,52H,9-12,18-21H2,1-2H3,(H,53,54)(H,46,47,49)/t26-,28-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446462
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-2-hydroxyprop...)
Show SMILES C[C@H](O)CNCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CC[C@](C)(C6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1
Show InChI InChI=1S/C41H42N8O4/c1-23(50)18-43-19-28-16-34-36(44-20-28)38(46-26(4)45-34)47-33-11-7-9-31(25(33)3)30-8-6-10-32(24(30)2)39-48-35-15-27(14-29(17-42)37(35)53-39)21-49-13-12-41(5,22-49)40(51)52/h6-11,14-16,20,23,43,50H,12-13,18-19,21-22H2,1-5H3,(H,51,52)(H,45,46,47)/t23-,41+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446461
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-1-hydroxyprop...)
Show SMILES C[C@@H](CO)NCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CC[C@](C)(C6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1
Show InChI InChI=1S/C41H42N8O4/c1-23(21-50)43-18-28-16-34-36(44-19-28)38(46-26(4)45-34)47-33-11-7-9-31(25(33)3)30-8-6-10-32(24(30)2)39-48-35-15-27(14-29(17-42)37(35)53-39)20-49-13-12-41(5,22-49)40(51)52/h6-11,14-16,19,23,43,50H,12-13,18,20-22H2,1-5H3,(H,51,52)(H,45,46,47)/t23-,41+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446460
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-3-hydroxy-3-m...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@](C)(C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@](C)(O)C3)cc2n1
Show InChI InChI=1S/C43H44N8O4/c1-25-31(8-6-10-33(25)40-49-36-17-28(16-30(19-44)38(36)55-40)21-50-14-12-42(4,23-50)41(52)53)32-9-7-11-34(26(32)2)48-39-37-35(46-27(3)47-39)18-29(20-45-37)22-51-15-13-43(5,54)24-51/h6-11,16-18,20,54H,12-15,21-24H2,1-5H3,(H,52,53)(H,46,47,48)/t42-,43+/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446459
PNG
((R)-1-((7-cyano-2-(3′-(7-(((R)-3-hydroxy-3-m...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@](C)(C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@](C)(O)C3)cc2n1
Show InChI InChI=1S/C43H44N8O4/c1-25-31(8-6-10-33(25)40-49-36-17-28(16-30(19-44)38(36)55-40)21-50-14-12-42(4,23-50)41(52)53)32-9-7-11-34(26(32)2)48-39-37-35(46-27(3)47-39)18-29(20-45-37)22-51-15-13-43(5,54)24-51/h6-11,16-18,20,54H,12-15,21-24H2,1-5H3,(H,52,53)(H,46,47,48)/t42-,43-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446458
PNG
((R)-1-((7-cyano-2-(3′-(7-(((R)-3-hydroxypyrr...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@](C)(C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@H](O)C3)cc2n1
Show InChI InChI=1S/C42H42N8O4/c1-24-31(7-5-9-33(24)40-48-36-16-27(15-29(18-43)38(36)54-40)20-50-14-12-42(4,23-50)41(52)53)32-8-6-10-34(25(32)2)47-39-37-35(45-26(3)46-39)17-28(19-44-37)21-49-13-11-30(51)22-49/h5-10,15-17,19,30,51H,11-14,20-23H2,1-4H3,(H,52,53)(H,45,46,47)/t30-,42-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446456
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-1-hydroxyprop...)
Show SMILES C[C@@H](CO)NCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CC[C@H](C6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1
Show InChI InChI=1S/C40H40N8O4/c1-22(21-49)42-17-27-15-34-36(43-18-27)38(45-25(4)44-34)46-33-10-6-8-31(24(33)3)30-7-5-9-32(23(30)2)39-47-35-14-26(13-29(16-41)37(35)52-39)19-48-12-11-28(20-48)40(50)51/h5-10,13-15,18,22,28,42,49H,11-12,17,19-21H2,1-4H3,(H,50,51)(H,44,45,46)/t22-,28+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446457
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-2-hydroxyprop...)
Show SMILES C[C@H](O)CNCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CC[C@H](C6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1
Show InChI InChI=1S/C40H40N8O4/c1-22(49)17-42-18-27-15-34-36(43-19-27)38(45-25(4)44-34)46-33-10-6-8-31(24(33)3)30-7-5-9-32(23(30)2)39-47-35-14-26(13-29(16-41)37(35)52-39)20-48-12-11-28(21-48)40(50)51/h5-10,13-15,19,22,28,42,49H,11-12,17-18,20-21H2,1-4H3,(H,50,51)(H,44,45,46)/t22-,28+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446455
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-3-hydroxy-3-m...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@H](C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@](C)(O)C3)cc2n1
Show InChI InChI=1S/C42H42N8O4/c1-24-31(7-5-9-33(24)40-48-36-16-27(15-30(18-43)38(36)54-40)20-49-13-11-29(22-49)41(51)52)32-8-6-10-34(25(32)2)47-39-37-35(45-26(3)46-39)17-28(19-44-37)21-50-14-12-42(4,53)23-50/h5-10,15-17,19,29,53H,11-14,20-23H2,1-4H3,(H,51,52)(H,45,46,47)/t29-,42+/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446454
PNG
((R)-1-((7-cyano-2-(3′-(7-(((R)-3-hydroxy-3-m...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@H](C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@](C)(O)C3)cc2n1
Show InChI InChI=1S/C42H42N8O4/c1-24-31(7-5-9-33(24)40-48-36-16-27(15-30(18-43)38(36)54-40)20-49-13-11-29(22-49)41(51)52)32-8-6-10-34(25(32)2)47-39-37-35(45-26(3)46-39)17-28(19-44-37)21-50-14-12-42(4,53)23-50/h5-10,15-17,19,29,53H,11-14,20-23H2,1-4H3,(H,51,52)(H,45,46,47)/t29-,42-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446453
PNG
((R)-1-((7-cyano-2-(3′-(7-(((R)-3-hydroxypyrr...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@H](C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@H](O)C3)cc2n1
Show InChI InChI=1S/C41H40N8O4/c1-23-31(6-4-8-33(23)40-47-36-15-26(14-29(17-42)38(36)53-40)19-48-12-10-28(21-48)41(51)52)32-7-5-9-34(24(32)2)46-39-37-35(44-25(3)45-39)16-27(18-43-37)20-49-13-11-30(50)22-49/h4-9,14-16,18,28,30,50H,10-13,19-22H2,1-3H3,(H,51,52)(H,44,45,46)/t28-,30-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446452
PNG
((S)-1-((7-cyano-2-(3′-(7-((2-hydroxypropylam...)
Show SMILES C[C@H](O)CNCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CCC(CC6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1
Show InChI InChI=1S/C41H42N8O4/c1-23(50)19-43-20-28-17-35-37(44-21-28)39(46-26(4)45-35)47-34-10-6-8-32(25(34)3)31-7-5-9-33(24(31)2)40-48-36-16-27(15-30(18-42)38(36)53-40)22-49-13-11-29(12-14-49)41(51)52/h5-10,15-17,21,23,29,43,50H,11-14,19-20,22H2,1-4H3,(H,51,52)(H,45,46,47)/t23-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446451
PNG
((S)-1-((7-cyano-2-(3′-(7-((1-hydroxypropan-2...)
Show SMILES C[C@@H](CO)NCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CCC(CC6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1
Show InChI InChI=1S/C41H42N8O4/c1-23(22-50)43-19-28-17-35-37(44-20-28)39(46-26(4)45-35)47-34-10-6-8-32(25(34)3)31-7-5-9-33(24(31)2)40-48-36-16-27(15-30(18-42)38(36)53-40)21-49-13-11-29(12-14-49)41(51)52/h5-10,15-17,20,23,29,43,50H,11-14,19,21-22H2,1-4H3,(H,51,52)(H,45,46,47)/t23-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446450
PNG
((S)-1-((7-cyano-2-(3′-(7-((3-hydroxy-3-methy...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CCC(CC5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@](C)(O)C3)cc2n1
Show InChI InChI=1S/C43H44N8O4/c1-25-32(7-5-9-34(25)41-49-37-18-28(17-31(20-44)39(37)55-41)22-50-14-11-30(12-15-50)42(52)53)33-8-6-10-35(26(33)2)48-40-38-36(46-27(3)47-40)19-29(21-45-38)23-51-16-13-43(4,54)24-51/h5-10,17-19,21,30,54H,11-16,22-24H2,1-4H3,(H,52,53)(H,46,47,48)/t43-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446448
PNG
((R)-1-((7-cyano-2-(3′-(7-((3-hydroxypyrrolid...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CCC(CC5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@H](O)C3)cc2n1
Show InChI InChI=1S/C42H42N8O4/c1-24-32(6-4-8-34(24)41-48-37-17-27(16-30(19-43)39(37)54-41)21-49-13-10-29(11-14-49)42(52)53)33-7-5-9-35(25(33)2)47-40-38-36(45-26(3)46-40)18-28(20-44-38)22-50-15-12-31(51)23-50/h4-9,16-18,20,29,31,51H,10-15,21-23H2,1-3H3,(H,52,53)(H,45,46,47)/t31-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM446449
PNG
((R)-1-((7-cyano-2-(3′-(7-((3-hydroxy-3-methy...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CCC(CC5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@](C)(O)C3)cc2n1
Show InChI InChI=1S/C43H44N8O4/c1-25-32(7-5-9-34(25)41-49-37-18-28(17-31(20-44)39(37)55-41)22-50-14-11-30(12-15-50)42(52)53)33-8-6-10-35(26(33)2)48-40-38-36(46-27(3)47-40)19-29(21-45-38)23-51-16-13-43(4,54)24-51/h5-10,17-19,21,30,54H,11-16,22-24H2,1-4H3,(H,52,53)(H,46,47,48)/t43-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...


US Patent US10669271 (2020)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49488
PNG
((E)-3-amino-2-[2-[[5-(1,3-benzodioxol-5-yl)-1,3,4-...)
Show SMILES CC(=N)C(C#N)C(=O)CSc1nnc(o1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C15H12N4O4S/c1-8(17)10(5-16)11(20)6-24-15-19-18-14(23-15)9-2-3-12-13(4-9)22-7-21-12/h2-4,10,17H,6-7H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEBI
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 59n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49853
PNG
(2-(4-propoxyphenyl)imidazo[1,2-a]pyridine | MLS000...)
Show SMILES CCCOc1ccc(cc1)-c1cn2ccccc2n1
Show InChI InChI=1S/C16H16N2O/c1-2-11-19-14-8-6-13(7-9-14)15-12-18-10-4-3-5-16(18)17-15/h3-10,12H,2,11H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 59n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49476
PNG
((E)-1-phenyl-3-phenylazanyl-prop-2-en-1-one | (E)-...)
Show SMILES O=C(CC=Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H13NO/c17-15(13-7-3-1-4-8-13)11-12-16-14-9-5-2-6-10-14/h1-10,12H,11H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 59n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM43368
PNG
((1-acetamido-2,2,2-trichloroethyl) N,N-dimethylcar...)
Show SMILES CN(C)C(=S)SC(NC(C)=O)C(Cl)(Cl)Cl
Show InChI InChI=1S/C7H11Cl3N2OS2/c1-4(13)11-5(7(8,9)10)15-6(14)12(2)3/h5H,1-3H3,(H,11,13)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PCBioAssay
n/an/an/an/a 59n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49606
PNG
(6-Bromo-2-(3,4-dichloro-phenyl)-imidazo[1,2-a]pyri...)
Show SMILES Clc1ccc(cc1Cl)-c1cn2cc(Br)ccc2n1
Show InChI InChI=1S/C13H7BrCl2N2/c14-9-2-4-13-17-12(7-18(13)6-9)8-1-3-10(15)11(16)5-8/h1-7H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
PCBioAssay
n/an/an/an/a 62n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49493
PNG
(2-(5-bromanylthiophen-2-yl)imidazo[1,2-a]pyridine ...)
Show SMILES Brc1ccc(s1)-c1cn2ccccc2n1
Show InChI InChI=1S/C11H7BrN2S/c12-10-5-4-9(15-10)8-7-14-6-2-1-3-11(14)13-8/h1-7H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 94n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49856
PNG
((Z)-1-(1,3-benzodioxol-5-yl)-3-(2-bromoanilino)-2-...)
Show SMILES Brc1ccccc1N=CCC(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C16H12BrNO3/c17-12-3-1-2-4-13(12)18-8-7-14(19)11-5-6-15-16(9-11)21-10-20-15/h1-6,8-9H,7,10H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 96n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49857
PNG
(7-(2-oxidanylidenepropylsulfanyl)-2,3-dihydro-[1,4...)
Show SMILES CC(=O)CSc1nc2cc3OCCOc3cc2cc1C#N
Show InChI InChI=1S/C15H12N2O3S/c1-9(18)8-21-15-11(7-16)4-10-5-13-14(6-12(10)17-15)20-3-2-19-13/h4-6H,2-3,8H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 104n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49427
PNG
((4-heptoxyphenyl) pyridine-4-carboxylate | 4-pyrid...)
Show SMILES CCCCCCCOc1ccc(OC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C19H23NO3/c1-2-3-4-5-6-15-22-17-7-9-18(10-8-17)23-19(21)16-11-13-20-14-12-16/h7-14H,2-6,15H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
PCBioAssay
n/an/an/an/a 107n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49777
PNG
(1-(1,3-benzodioxol-5-yl)-3-(2,3-dihydro-1,4-benzod...)
Show SMILES O=C(Nc1ccc2OCOc2c1)Nc1ccc2OCCOc2c1
Show InChI InChI=1S/C16H14N2O5/c19-16(18-11-2-4-13-15(8-11)23-9-22-13)17-10-1-3-12-14(7-10)21-6-5-20-12/h1-4,7-8H,5-6,9H2,(H2,17,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
PCBioAssay
n/an/an/an/a 114n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49255
PNG
(2-(4-fluorophenyl)-5H-[1,2,4]triazol[5,1-a]isoindo...)
Show SMILES Fc1ccc(cc1)-c1nc2-c3ccccc3Cn2n1
Show InChI InChI=1S/C15H10FN3/c16-12-7-5-10(6-8-12)14-17-15-13-4-2-1-3-11(13)9-19(15)18-14/h1-8H,9H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 125n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49217
PNG
(3-(1,3-benzodioxol-5-ylmethylideneamino)-N,4-dimet...)
Show SMILES C\N=c1/scc(C)n1N=Cc1ccc2OCOc2c1
Show InChI InChI=1S/C13H13N3O2S/c1-9-7-19-13(14-2)16(9)15-6-10-3-4-11-12(5-10)18-8-17-11/h3-7H,8H2,1-2H3/b14-13-,15-6?
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 129n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49842
PNG
(3-(7-methyl-2-imidazo[1,2-a]pyridinyl)-1-benzopyra...)
Show SMILES Cc1ccn2cc(nc2c1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C17H12N2O2/c1-11-6-7-19-10-14(18-16(19)8-11)13-9-12-4-2-3-5-15(12)21-17(13)20/h2-10H,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

PCBioAssay
n/an/an/an/a 137n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49591
PNG
(Benzo[1,3]dioxole-5-carboxylic acid benzothiazol-2...)
Show SMILES O=C(Nc1nc2ccccc2s1)c1ccc2OCOc2c1
Show InChI InChI=1S/C15H10N2O3S/c18-14(9-5-6-11-12(7-9)20-8-19-11)17-15-16-10-3-1-2-4-13(10)21-15/h1-7H,8H2,(H,16,17,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 138n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49179
PNG
((3-Cyano-7-methoxy-quinolin-2-ylsulfanyl)-acetic a...)
Show SMILES CCOC(=O)CSc1nc2cc(OC)ccc2cc1C#N
Show InChI InChI=1S/C15H14N2O3S/c1-3-20-14(18)9-21-15-11(8-16)6-10-4-5-12(19-2)7-13(10)17-15/h4-7H,3,9H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 144n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49576
PNG
(2-(4-aminophenyl)-1,3-benzothiazole-6-carboxylic a...)
Show SMILES Nc1ccc(cc1)-c1nc2ccc(cc2s1)C(O)=O
Show InChI InChI=1S/C14H10N2O2S/c15-10-4-1-8(2-5-10)13-16-11-6-3-9(14(17)18)7-12(11)19-13/h1-7H,15H2,(H,17,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

PCBioAssay
n/an/an/an/a 146n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 3823 total )  |  Next  |  Last  >>
Jump to: