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Compile Data Set for Download or QSAR

Found 104 hits Enz. Inhib. hit(s) with Target = 'Parathyroid hormone receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246337
PNG
(CHEMBL4084894)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1/C174H300N56O49/c1-26-93(20)136(228-165(274)126(80-232)224-141(250)101(39-28-32-56-176)200-129(236)78-195-140(249)100(38-27-31-55-175)201-161(270)123(73-133(243)244)223-160(269)121(71-98-76-190-82-197-98)220-158(267)118(68-90(14)15)216-155(264)114(64-86(6)7)213-148(257)107(45-50-127(180)234)207-159(268)120(70-97-75-189-81-196-97)219-151(260)111(49-54-132(241)242)209-164(273)125(79-231)225-167(276)135(92(18)19)227-139(248)94(21)179)168(277)210-108(46-51-128(181)235)149(258)222-124(74-134(245)246)162(271)217-112(62-84(2)3)152(261)205-105(44-37-61-194-173(187)188)143(252)203-103(42-35-59-192-171(183)184)142(251)204-104(43-36-60-193-172(185)186)144(253)206-110(48-53-131(239)240)150(259)214-115(65-87(8)9)154(263)215-113(63-85(4)5)153(262)208-109(47-52-130(237)238)147(256)202-102(40-29-33-57-177)145(254)211-116(66-88(10)11)156(265)218-119(69-91(16)17)166(275)230-174(24,25)170(279)226-106(41-30-34-58-178)146(255)212-117(67-89(12)13)157(266)221-122(72-99-77-191-83-198-99)163(272)229-137(96(23)233)169(278)199-95(22)138(182)247/h75-77,81-96,100-126,135-137,231-233H,26-74,78-80,175-179H2,1-25H3,(H2,180,234)(H2,181,235)(H2,182,247)(H,189,196)(H,190,197)(H,191,198)(H,195,249)(H,199,278)(H,200,236)(H,201,270)(H,202,256)(H,203,252)(H,204,251)(H,205,261)(H,206,253)(H,207,268)(H,208,262)(H,209,273)(H,210,277)(H,211,254)(H,212,255)(H,213,257)(H,214,259)(H,215,263)(H,216,264)(H,217,271)(H,218,265)(H,219,260)(H,220,267)(H,221,266)(H,222,258)(H,223,269)(H,224,250)(H,225,276)(H,226,279)(H,227,248)(H,228,274)(H,229,272)(H,230,275)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H4,183,184,192)(H4,185,186,193)(H4,187,188,194)/t93-,94-,95-,96+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,135-,136-,137-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.0200n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246318
PNG
(CHEMBL4098420)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)148(238-162(270)115(48-53-143(253)254)214-176(284)133(85-241)234-177(285)145(94(12)13)235-139(247)70-100(186)83-239)180(288)218-112(45-50-135(188)243)157(265)222-121(65-91(6)7)165(273)215-117(55-62-290-20)160(268)227-126(72-102-80-198-87-205-102)169(277)230-129(75-137(190)245)172(280)220-119(63-89(2)3)150(258)203-82-140(248)207-106(39-27-30-56-183)151(259)226-125(71-101-79-197-86-204-101)168(276)224-123(67-93(10)11)166(274)228-130(76-138(191)246)173(281)233-132(84-240)175(283)216-116(54-61-289-19)159(267)212-113(46-51-141(249)250)155(263)210-110(43-34-60-201-182(195)196)161(269)236-146(95(14)15)178(286)217-114(47-52-142(251)252)158(266)225-124(69-99-78-202-105-38-26-25-37-104(99)105)167(275)223-122(66-92(8)9)163(271)211-109(42-33-59-200-181(193)194)153(261)208-107(40-28-31-57-184)152(260)209-108(41-29-32-58-185)154(262)221-120(64-90(4)5)164(272)213-111(44-49-134(187)242)156(264)231-131(77-144(255)256)174(282)237-147(96(16)17)179(287)232-127(73-103-81-199-88-206-103)170(278)229-128(74-136(189)244)171(279)219-118(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,100,106-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,258)(H,207,248)(H,208,261)(H,209,260)(H,210,263)(H,211,271)(H,212,267)(H,213,272)(H,214,284)(H,215,273)(H,216,283)(H,217,286)(H,218,288)(H,219,279)(H,220,280)(H,221,262)(H,222,265)(H,223,275)(H,224,276)(H,225,266)(H,226,259)(H,227,268)(H,228,274)(H,229,278)(H,230,277)(H,231,264)(H,232,287)(H,233,281)(H,234,285)(H,235,247)(H,236,269)(H,237,282)(H,238,270)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,100+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.0600n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269975
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C77H129N23O19/c1-13-15-20-47(91-69(114)54(35-40(3)4)95-67(112)51(28-31-57(80)103)93-71(116)60(42(7)14-2)98-68(113)52(29-32-58(104)105)97-74(119)77(11,12)100-72(117)59(41(5)6)99-73(118)76(9,10)84)65(110)96-55(37-45-38-85-39-87-45)70(115)92-50(27-30-56(79)102)66(111)90-48(22-17-19-34-86-75(82)83)63(108)88-43(8)62(107)89-49(21-16-18-33-78)64(109)94-53(61(81)106)36-44-23-25-46(101)26-24-44/h23-26,38-43,47-55,59-60,101H,13-22,27-37,78,84H2,1-12H3,(H2,79,102)(H2,80,103)(H2,81,106)(H,85,87)(H,88,108)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,116)(H,94,109)(H,95,112)(H,96,110)(H,97,119)(H,98,113)(H,99,118)(H,100,117)(H,104,105)(H4,82,83,86)/t42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0600n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246319
PNG
(CHEMBL4080397)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C181H292N56O50S2/c1-21-96(18)146(237-161(269)114(48-53-141(251)252)213-175(283)132(84-240)233-178(286)143(93(12)13)234-148(256)103(185)82-238)179(287)217-111(45-50-134(187)242)156(264)221-120(65-90(6)7)164(272)214-116(55-62-289-20)159(267)226-125(71-100-79-197-86-204-100)168(276)229-128(74-136(189)244)171(279)219-118(63-88(2)3)149(257)202-81-138(246)206-105(39-27-30-56-182)150(258)225-124(70-99-78-196-85-203-99)167(275)223-122(67-92(10)11)165(273)227-129(75-137(190)245)172(280)232-131(83-239)174(282)215-115(54-61-288-19)158(266)211-112(46-51-139(247)248)154(262)209-109(43-34-60-200-181(194)195)160(268)235-144(94(14)15)176(284)216-113(47-52-140(249)250)157(265)224-123(69-98-77-201-104-38-26-25-37-102(98)104)166(274)222-121(66-91(8)9)162(270)210-108(42-33-59-199-180(192)193)152(260)207-106(40-28-31-57-183)151(259)208-107(41-29-32-58-184)153(261)220-119(64-89(4)5)163(271)212-110(44-49-133(186)241)155(263)230-130(76-142(253)254)173(281)236-145(95(16)17)177(285)231-126(72-101-80-198-87-205-101)169(277)228-127(73-135(188)243)170(278)218-117(147(191)255)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,201,238-240H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,255)(H,196,203)(H,197,204)(H,198,205)(H,202,257)(H,206,246)(H,207,260)(H,208,259)(H,209,262)(H,210,270)(H,211,266)(H,212,271)(H,213,283)(H,214,272)(H,215,282)(H,216,284)(H,217,287)(H,218,278)(H,219,279)(H,220,261)(H,221,264)(H,222,274)(H,223,275)(H,224,265)(H,225,258)(H,226,267)(H,227,273)(H,228,277)(H,229,276)(H,230,263)(H,231,285)(H,232,280)(H,233,286)(H,234,256)(H,235,268)(H,236,281)(H,237,269)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,192,193,199)(H4,194,195,200)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.0700n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246362
PNG
(CHEMBL4060034)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1/C180H288N58O47/c1-23-94(16)141(174(282)208-99(21)147(255)210-116(51-55-137(247)248)156(264)235-143(96(18)25-3)176(284)231-128(72-107-79-197-87-206-107)170(278)238-144(100(22)241)177(285)207-98(20)145(186)253)236-169(277)121(65-92(12)13)222-164(272)125(69-104-76-194-84-203-104)228-165(273)126(70-105-77-195-85-204-105)226-160(268)120(64-91(10)11)220-161(269)123(67-102-41-30-27-31-42-102)224-162(270)122(66-101-39-28-26-29-40-101)223-152(260)112(47-38-60-200-180(191)192)213-150(258)110(45-36-58-198-178(187)188)212-151(259)111(46-37-59-199-179(189)190)214-157(265)117(61-88(4)5)221-168(276)130(74-139(251)252)229-154(262)114(49-53-134(185)243)217-175(283)142(95(17)24-2)237-172(280)132(82-240)232-149(257)109(44-33-35-57-182)209-135(244)80-201-148(256)108(43-32-34-56-181)211-167(275)129(73-138(249)250)230-166(274)127(71-106-78-196-86-205-106)227-159(267)119(63-90(8)9)219-158(266)118(62-89(6)7)218-153(261)113(48-52-133(184)242)215-163(271)124(68-103-75-193-83-202-103)225-155(263)115(50-54-136(245)246)216-171(279)131(81-239)233-173(281)140(93(14)15)234-146(254)97(19)183/h26-31,39-42,75-79,83-100,108-132,140-144,239-241H,23-25,32-38,43-74,80-82,181-183H2,1-22H3,(H2,184,242)(H2,185,243)(H2,186,253)(H,193,202)(H,194,203)(H,195,204)(H,196,205)(H,197,206)(H,201,256)(H,207,285)(H,208,282)(H,209,244)(H,210,255)(H,211,275)(H,212,259)(H,213,258)(H,214,265)(H,215,271)(H,216,279)(H,217,283)(H,218,261)(H,219,266)(H,220,269)(H,221,276)(H,222,272)(H,223,260)(H,224,270)(H,225,263)(H,226,268)(H,227,267)(H,228,273)(H,229,262)(H,230,274)(H,231,284)(H,232,257)(H,233,281)(H,234,254)(H,235,264)(H,236,277)(H,237,280)(H,238,278)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H4,187,188,198)(H4,189,190,199)(H4,191,192,200)/t94-,95-,96-,97-,98-,99-,100+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,140-,141-,142-,143-,144-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0800n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246387
PNG
(CHEMBL4090619)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C181H290N56O50S2/c1-19-95(16)146(237-162(270)115(49-54-141(251)252)215-175(283)132(84-240)233-178(286)143(92(10)11)234-149(257)103(185)82-238)179(287)218-112(46-51-134(187)242)155(263)207-105-42-31-37-102(105)148(256)208-116(55-62-288-17)160(268)226-125(71-99-79-197-86-204-99)168(276)229-128(74-136(189)244)171(279)220-119(64-88(2)3)150(258)202-81-138(246)206-106(39-25-28-57-182)151(259)225-124(70-98-78-196-85-203-98)167(275)223-122(67-91(8)9)165(273)227-129(75-137(190)245)172(280)232-131(83-239)174(282)216-117(56-63-289-18)159(267)213-113(47-52-139(247)248)156(264)211-110(44-33-61-200-181(194)195)161(269)235-144(93(12)13)176(284)217-114(48-53-140(249)250)158(266)224-123(69-97-77-201-104-38-24-23-36-101(97)104)166(274)222-121(66-90(6)7)163(271)212-109(43-32-60-199-180(192)193)153(261)209-107(40-26-29-58-183)152(260)210-108(41-27-30-59-184)154(262)221-120(65-89(4)5)164(272)214-111(45-50-133(186)241)157(265)230-130(76-142(253)254)173(281)236-145(94(14)15)177(285)231-126(72-100-80-198-87-205-100)169(277)228-127(73-135(188)243)170(278)219-118(147(191)255)68-96-34-21-20-22-35-96/h20-24,34-36,38,77-80,85-95,102-103,105-132,143-146,201,238-240H,19,25-33,37,39-76,81-84,182-185H2,1-18H3,(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,255)(H,196,203)(H,197,204)(H,198,205)(H,202,258)(H,206,246)(H,207,263)(H,208,256)(H,209,261)(H,210,260)(H,211,264)(H,212,271)(H,213,267)(H,214,272)(H,215,283)(H,216,282)(H,217,284)(H,218,287)(H,219,278)(H,220,279)(H,221,262)(H,222,274)(H,223,275)(H,224,266)(H,225,259)(H,226,268)(H,227,273)(H,228,277)(H,229,276)(H,230,265)(H,231,285)(H,232,280)(H,233,286)(H,234,257)(H,235,269)(H,236,281)(H,237,270)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,192,193,199)(H4,194,195,200)/t95-,102-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.120n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246270
PNG
(CHEMBL4088173)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C184H294N56O49S2/c1-19-97(16)149(240-165(272)118(52-57-144(253)254)218-178(285)135(86-242)236-181(288)146(94(10)11)237-151(258)104-38-31-40-106(104)188)182(289)221-115(49-54-137(190)244)158(265)210-108-45-32-39-105(108)152(259)211-119(58-65-290-17)163(270)229-128(74-101-82-200-88-207-101)171(278)232-131(77-139(192)246)174(281)223-122(67-90(2)3)153(260)205-84-141(248)209-109(42-25-28-60-185)154(261)228-127(73-100-81-199-87-206-100)170(277)226-125(70-93(8)9)168(275)230-132(78-140(193)247)175(282)235-134(85-241)177(284)219-120(59-66-291-18)162(269)216-116(50-55-142(249)250)159(266)214-113(47-34-64-203-184(197)198)164(271)238-147(95(12)13)179(286)220-117(51-56-143(251)252)161(268)227-126(72-99-80-204-107-41-24-23-37-103(99)107)169(276)225-124(69-92(6)7)166(273)215-112(46-33-63-202-183(195)196)156(263)212-110(43-26-29-61-186)155(262)213-111(44-27-30-62-187)157(264)224-123(68-91(4)5)167(274)217-114(48-53-136(189)243)160(267)233-133(79-145(255)256)176(283)239-148(96(14)15)180(287)234-129(75-102-83-201-89-208-102)172(279)231-130(76-138(191)245)173(280)222-121(150(194)257)71-98-35-21-20-22-36-98/h20-24,35-37,41,80-83,87-97,104-106,108-135,146-149,204,241-242H,19,25-34,38-40,42-79,84-86,185-188H2,1-18H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,260)(H,209,248)(H,210,265)(H,211,259)(H,212,263)(H,213,262)(H,214,266)(H,215,273)(H,216,269)(H,217,274)(H,218,285)(H,219,284)(H,220,286)(H,221,289)(H,222,280)(H,223,281)(H,224,264)(H,225,276)(H,226,277)(H,227,268)(H,228,261)(H,229,270)(H,230,275)(H,231,279)(H,232,278)(H,233,267)(H,234,287)(H,235,282)(H,236,288)(H,237,258)(H,238,271)(H,239,283)(H,240,272)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t97-,104-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,146-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.140n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246293
PNG
(CHEMBL4061182)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C184H296N56O49S2/c1-21-98(18)149(240-164(271)117(51-56-144(253)254)216-178(285)135(86-242)236-181(288)146(95(12)13)237-151(258)105-39-33-40-106(105)188)182(289)220-114(48-53-137(190)244)159(266)224-123(68-92(6)7)167(274)217-119(58-65-291-20)162(269)229-128(74-102-82-200-88-207-102)171(278)232-131(77-139(192)246)174(281)222-121(66-90(2)3)152(259)205-84-141(248)209-108(42-27-30-59-185)153(260)228-127(73-101-81-199-87-206-101)170(277)226-125(70-94(10)11)168(275)230-132(78-140(193)247)175(282)235-134(85-241)177(284)218-118(57-64-290-19)161(268)214-115(49-54-142(249)250)157(264)212-112(46-35-63-203-184(197)198)163(270)238-147(96(14)15)179(286)219-116(50-55-143(251)252)160(267)227-126(72-100-80-204-107-41-26-25-38-104(100)107)169(276)225-124(69-93(8)9)165(272)213-111(45-34-62-202-183(195)196)155(262)210-109(43-28-31-60-186)154(261)211-110(44-29-32-61-187)156(263)223-122(67-91(4)5)166(273)215-113(47-52-136(189)243)158(265)233-133(79-145(255)256)176(283)239-148(97(16)17)180(287)234-129(75-103-83-201-89-208-103)172(279)231-130(76-138(191)245)173(280)221-120(150(194)257)71-99-36-23-22-24-37-99/h22-26,36-38,41,80-83,87-98,105-106,108-135,146-149,204,241-242H,21,27-35,39-40,42-79,84-86,185-188H2,1-20H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,259)(H,209,248)(H,210,262)(H,211,261)(H,212,264)(H,213,272)(H,214,268)(H,215,273)(H,216,285)(H,217,274)(H,218,284)(H,219,286)(H,220,289)(H,221,280)(H,222,281)(H,223,263)(H,224,266)(H,225,276)(H,226,277)(H,227,267)(H,228,260)(H,229,269)(H,230,275)(H,231,279)(H,232,278)(H,233,265)(H,234,287)(H,235,282)(H,236,288)(H,237,258)(H,238,270)(H,239,283)(H,240,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t98-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,146-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246291
PNG
(CHEMBL4098344)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C181H290N56O50S2/c1-88(2)63-119(220-172(280)129(74-137(189)244)230-169(277)126(71-99-79-197-86-204-99)227-161(269)117(55-62-289-18)216-165(273)121(65-90(5)6)222-157(265)111(44-49-134(186)241)208-148(256)102-36-30-41-105(102)207-155(263)113(46-51-140(247)248)215-176(284)133(84-240)234-179(287)144(93(11)12)235-149(257)103(185)82-238)150(258)202-81-139(246)206-106(38-24-27-56-182)151(259)226-125(70-98-78-196-85-203-98)168(276)224-123(67-92(9)10)166(274)228-130(75-138(190)245)173(281)233-132(83-239)175(283)217-116(54-61-288-17)160(268)213-114(47-52-141(249)250)156(264)211-110(43-32-60-200-181(194)195)162(270)236-145(94(13)14)177(285)218-115(48-53-142(251)252)159(267)225-124(69-97-77-201-104-37-23-22-35-101(97)104)167(275)223-122(66-91(7)8)163(271)212-109(42-31-59-199-180(192)193)153(261)209-107(39-25-28-57-183)152(260)210-108(40-26-29-58-184)154(262)221-120(64-89(3)4)164(272)214-112(45-50-135(187)242)158(266)231-131(76-143(253)254)174(282)237-146(95(15)16)178(286)232-127(72-100-80-198-87-205-100)170(278)229-128(73-136(188)243)171(279)219-118(147(191)255)68-96-33-20-19-21-34-96/h19-23,33-35,37,77-80,85-95,102-103,105-133,144-146,201,238-240H,24-32,36,38-76,81-84,182-185H2,1-18H3,(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,255)(H,196,203)(H,197,204)(H,198,205)(H,202,258)(H,206,246)(H,207,263)(H,208,256)(H,209,261)(H,210,260)(H,211,264)(H,212,271)(H,213,268)(H,214,272)(H,215,284)(H,216,273)(H,217,283)(H,218,285)(H,219,279)(H,220,280)(H,221,262)(H,222,265)(H,223,275)(H,224,276)(H,225,267)(H,226,259)(H,227,269)(H,228,274)(H,229,278)(H,230,277)(H,231,266)(H,232,286)(H,233,281)(H,234,287)(H,235,257)(H,236,270)(H,237,282)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,192,193,199)(H4,194,195,200)/t102-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246250
PNG
(CHEMBL4106296)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1/C192H307N55O50S2/c1-21-105(18)163(247-174(281)129(52-57-158(267)268)230-186(293)143(94-250)243-189(296)162(104(16)17)245-164(271)119(196)92-248)190(297)232-128(50-54-145(198)252)171(278)235-134(70-100(8)9)179(286)231-130(59-66-299-20)172(279)237-137(75-115-89-207-95-214-115)181(288)240-140(85-148(201)255)183(290)233-131(67-97(2)3)165(272)213-91-155(262)224-122(44-30-33-61-194)166(273)220-113(73-107-87-211-120-42-27-25-40-117(107)120)81-153(260)225-132(68-98(4)5)176(283)239-141(86-149(202)256)184(291)242-142(93-249)185(292)217-111(58-65-298-19)80-151(258)223-126(51-56-157(265)266)170(277)227-125(47-36-64-210-192(205)206)173(280)246-161(103(14)15)187(294)218-110(48-55-156(263)264)79-152(259)226-136(74-108-88-212-121-43-28-26-41-118(108)121)180(287)236-135(71-101(10)11)177(284)228-124(46-35-63-209-191(203)204)167(274)216-109(39-29-32-60-193)78-150(257)222-123(45-31-34-62-195)169(276)234-133(69-99(6)7)178(285)229-127(49-53-144(197)251)168(275)221-114(83-159(269)270)82-154(261)244-160(102(12)13)188(295)241-138(76-116-90-208-96-215-116)182(289)238-139(84-147(200)254)175(282)219-112(77-146(199)253)72-106-37-23-22-24-38-106/h22-28,37-38,40-43,87-90,95-105,109-114,119,122-143,160-163,211-212,248-250H,21,29-36,39,44-86,91-94,193-196H2,1-20H3,(H2,197,251)(H2,198,252)(H2,199,253)(H2,200,254)(H2,201,255)(H2,202,256)(H,207,214)(H,208,215)(H,213,272)(H,216,274)(H,217,292)(H,218,294)(H,219,282)(H,220,273)(H,221,275)(H,222,257)(H,223,258)(H,224,262)(H,225,260)(H,226,259)(H,227,277)(H,228,284)(H,229,285)(H,230,293)(H,231,286)(H,232,297)(H,233,290)(H,234,276)(H,235,278)(H,236,287)(H,237,279)(H,238,289)(H,239,283)(H,240,288)(H,241,295)(H,242,291)(H,243,296)(H,244,261)(H,245,271)(H,246,280)(H,247,281)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H4,203,204,209)(H4,205,206,210)/t105-,109-,110-,111-,112-,113-,114+,119-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,160-,161-,162-,163-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246419
PNG
(CHEMBL4074628)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C179H300N56O46/c1-23-93(18)141(233-147(253)101-37-30-43-107(101)205-151(257)110(40-25-27-57-181)204-135(240)80-200-150(256)109(39-24-26-56-180)209-168(274)129(72-139(247)248)227-166(272)126(69-97-74-195-83-202-97)224-164(270)123(66-90(12)13)221-163(269)122(65-89(10)11)219-155(261)114(48-52-133(183)238)212-165(271)125(68-96-73-194-82-201-96)223-157(263)116(50-54-136(241)242)214-170(276)132(81-236)230-172(278)140(92(16)17)232-144(250)94(19)182)173(279)215-115(49-53-134(184)239)156(262)226-128(71-138(245)246)167(273)206-106-42-29-36-100(106)145(251)208-111(45-32-58-197-176(186)187)152(258)210-112(46-33-59-198-177(188)189)153(259)211-113(47-34-60-199-178(190)191)154(260)228-130-78-192-76-103(130)148(254)217-119(62-86(4)5)160(266)220-121(64-88(8)9)159(265)213-117(51-55-137(243)244)158(264)229-131-79-193-77-104(131)149(255)218-120(63-87(6)7)161(267)222-124(67-91(14)15)171(277)235-179(21,22)175(281)231-108-44-31-38-102(108)146(252)216-118(61-85(2)3)162(268)225-127(70-98-75-196-84-203-98)169(275)234-142(95(20)237)174(280)207-105-41-28-35-99(105)143(185)249/h73-75,82-95,99-132,140-142,192-193,236-237H,23-72,76-81,180-182H2,1-22H3,(H2,183,238)(H2,184,239)(H2,185,249)(H,194,201)(H,195,202)(H,196,203)(H,200,256)(H,204,240)(H,205,257)(H,206,273)(H,207,280)(H,208,251)(H,209,274)(H,210,258)(H,211,259)(H,212,271)(H,213,265)(H,214,276)(H,215,279)(H,216,252)(H,217,254)(H,218,255)(H,219,261)(H,220,266)(H,221,269)(H,222,267)(H,223,263)(H,224,270)(H,225,268)(H,226,262)(H,227,272)(H,228,260)(H,229,264)(H,230,278)(H,231,281)(H,232,250)(H,233,253)(H,234,275)(H,235,277)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H4,186,187,197)(H4,188,189,198)(H4,190,191,199)/t93-,94-,95+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,140-,141-,142-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.180n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50331021
PNG
((S)-5-((2S,3S)-1-((3S,6S,9S,12S,15S)-6-((1H-imidaz...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](COC(=O)CCCCC(=O)OC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC
Show InChI InChI=1/C61H103N17O17/c1-12-14-19-37-49(84)72-40(27-35-28-66-31-68-35)52(87)73-41(53(88)69-36(48(62)83)20-17-18-25-67-59(63)64)29-94-44(81)21-15-16-22-45(82)95-30-42(54(89)71-39(26-32(3)4)51(86)70-37)74-55(90)47(34(7)13-2)76-50(85)38(23-24-43(79)80)75-58(93)61(10,11)78-56(91)46(33(5)6)77-57(92)60(8,9)65/h28,31-34,36-42,46-47H,12-27,29-30,65H2,1-11H3,(H2,62,83)(H,66,68)(H,69,88)(H,70,86)(H,71,89)(H,72,84)(H,73,87)(H,74,90)(H,75,93)(H,76,85)(H,77,92)(H,78,91)(H,79,80)(H4,63,64,67)/t34-,36-,37-,38-,39-,40-,41-,42-,46-,47-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)


Article DOI: 10.1021/jm1008264
BindingDB Entry DOI: 10.7270/Q2GM87KQ
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246249
PNG
(CHEMBL4063722)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C180H295N55O46S/c1-20-93(18)145(235-162(265)117(50-54-141(247)248)214-174(277)133(82-238)231-177(280)143(91(14)15)233-152(255)104(183)80-236)178(281)216-115(48-52-135(185)240)159(262)221-122(64-88(8)9)165(268)215-118(55-60-282-19)160(263)223-125(67-95-73-196-83-202-95)168(271)226-128(70-137(187)242)171(274)219-119(61-85(2)3)153(256)201-79-139(244)204-110(39-23-25-56-181)154(257)206-107-42-29-36-100(107)148(251)217-120(62-86(4)5)166(269)224-129(71-138(188)243)172(275)230-132(81-237)173(276)208-108-43-28-35-99(108)147(250)210-116(49-53-140(245)246)158(261)211-113(46-32-59-199-180(192)193)161(264)234-144(92(16)17)176(279)229-131-78-195-76-103(131)151(254)218-124(66-94-72-200-105-38-22-21-33-97(94)105)167(270)222-123(65-89(10)11)163(266)212-112(45-31-58-198-179(190)191)156(259)228-130-77-194-75-102(130)150(253)209-111(40-24-26-57-182)155(258)220-121(63-87(6)7)164(267)213-114(47-51-134(184)239)157(260)207-109-44-30-37-101(109)149(252)232-142(90(12)13)175(278)227-126(68-96-74-197-84-203-96)169(272)225-127(69-136(186)241)170(273)205-106-41-27-34-98(106)146(189)249/h21-22,33,38,72-74,83-93,98-104,106-133,142-145,194-195,200,236-238H,20,23-32,34-37,39-71,75-82,181-183H2,1-19H3,(H2,184,239)(H2,185,240)(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,249)(H,196,202)(H,197,203)(H,201,256)(H,204,244)(H,205,273)(H,206,257)(H,207,260)(H,208,276)(H,209,253)(H,210,250)(H,211,261)(H,212,266)(H,213,267)(H,214,277)(H,215,268)(H,216,281)(H,217,251)(H,218,254)(H,219,274)(H,220,258)(H,221,262)(H,222,270)(H,223,263)(H,224,269)(H,225,272)(H,226,271)(H,227,278)(H,228,259)(H,229,279)(H,230,275)(H,231,280)(H,232,252)(H,233,255)(H,234,264)(H,235,265)(H,245,246)(H,247,248)(H4,190,191,198)(H4,192,193,199)/t93-,98-,99-,100-,101-,102-,103-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,142-,143-,144-,145-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 0.260n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246388
PNG
(CHEMBL4097998)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H292N56O50S2/c1-19-96(16)147(238-163(271)116(49-54-143(252)253)215-176(284)133(84-240)234-149(257)103-37-31-42-106(103)208-150(258)104(186)83-239)180(288)219-113(46-51-136(188)243)158(266)223-122(66-91(6)7)166(274)216-118(56-63-290-18)161(269)228-127(72-100-80-198-87-205-100)170(278)231-130(75-138(190)245)173(281)221-120(64-89(2)3)151(259)203-82-140(247)207-107(39-25-28-57-183)152(260)227-126(71-99-79-197-86-204-99)169(277)225-124(68-93(10)11)167(275)229-131(76-139(191)246)174(282)235-134(85-241)177(285)217-117(55-62-289-17)160(268)213-114(47-52-141(248)249)156(264)211-111(44-33-61-201-182(195)196)162(270)236-145(94(12)13)178(286)218-115(48-53-142(250)251)159(267)226-125(70-98-78-202-105-38-24-23-36-102(98)105)168(276)224-123(67-92(8)9)164(272)212-110(43-32-60-200-181(193)194)154(262)209-108(40-26-29-58-184)153(261)210-109(41-27-30-59-185)155(263)222-121(65-90(4)5)165(273)214-112(45-50-135(187)242)157(265)232-132(77-144(254)255)175(283)237-146(95(14)15)179(287)233-128(73-101-81-199-88-206-101)171(279)230-129(74-137(189)244)172(280)220-119(148(192)256)69-97-34-21-20-22-35-97/h20-24,34-36,38,78-81,86-96,103-104,106-134,145-147,202,239-241H,19,25-33,37,39-77,82-85,183-186H2,1-18H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,256)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,247)(H,208,258)(H,209,262)(H,210,261)(H,211,264)(H,212,272)(H,213,268)(H,214,273)(H,215,284)(H,216,274)(H,217,285)(H,218,286)(H,219,288)(H,220,280)(H,221,281)(H,222,263)(H,223,266)(H,224,276)(H,225,277)(H,226,267)(H,227,260)(H,228,269)(H,229,275)(H,230,279)(H,231,278)(H,232,265)(H,233,287)(H,234,257)(H,235,282)(H,236,270)(H,237,283)(H,238,271)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,193,194,200)(H4,195,196,201)/t96-,103-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,145-,146-,147-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.270n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246317
PNG
(CHEMBL4063322)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)C[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)148(238-163(271)115(48-53-144(253)254)215-176(284)133(84-240)208-140(247)76-118(94(12)13)220-150(258)104(186)83-239)180(288)219-112(45-50-136(188)243)158(266)224-122(65-91(6)7)166(274)216-117(55-62-290-20)161(269)229-127(71-101-80-198-87-205-101)170(278)232-130(74-138(190)245)173(281)222-120(63-89(2)3)151(259)203-82-141(248)207-106(39-27-30-56-183)152(260)228-126(70-100-79-197-86-204-100)169(277)226-124(67-93(10)11)167(275)230-131(75-139(191)246)174(282)235-134(85-241)177(285)217-116(54-61-289-19)160(268)213-113(46-51-142(249)250)156(264)211-110(43-34-60-201-182(195)196)162(270)236-146(95(14)15)178(286)218-114(47-52-143(251)252)159(267)227-125(69-99-78-202-105-38-26-25-37-103(99)105)168(276)225-123(66-92(8)9)164(272)212-109(42-33-59-200-181(193)194)154(262)209-107(40-28-31-57-184)153(261)210-108(41-29-32-58-185)155(263)223-121(64-90(4)5)165(273)214-111(44-49-135(187)242)157(265)233-132(77-145(255)256)175(283)237-147(96(16)17)179(287)234-128(72-102-81-199-88-206-102)171(279)231-129(73-137(189)244)172(280)221-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,104,106-134,146-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,248)(H,208,247)(H,209,262)(H,210,261)(H,211,264)(H,212,272)(H,213,268)(H,214,273)(H,215,284)(H,216,274)(H,217,285)(H,218,286)(H,219,288)(H,220,258)(H,221,280)(H,222,281)(H,223,263)(H,224,266)(H,225,276)(H,226,277)(H,227,267)(H,228,260)(H,229,269)(H,230,275)(H,231,279)(H,232,278)(H,233,265)(H,234,287)(H,235,282)(H,236,270)(H,237,283)(H,238,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.290n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.300n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP production


J Med Chem 53: 4332-53 (2010)


Article DOI: 10.1021/jm9018756
BindingDB Entry DOI: 10.7270/Q21R6QPF
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246339
PNG
(CHEMBL4106303)
Show SMILES CC[C@H](C)[C@H](NC(=O)C[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)CC(N)=O)Cc1ccccc1
Show InChI InChI=1/C186H305N57O47/c1-23-101(16)153(240-146(254)81-118(89-244)218-160(267)120(47-34-37-61-189)220-147(255)88-207-159(266)119(46-33-36-60-188)223-175(282)137(83-151(262)263)236-174(281)134(75-116-86-202-93-210-116)234-171(278)129(68-98(10)11)230-169(276)128(67-97(8)9)229-164(271)124(52-55-139(191)247)226-173(280)133(74-115-85-201-92-209-115)232-166(273)126(54-58-149(258)259)227-178(285)138(90-245)238-179(286)152(100(14)15)241-157(264)105(20)190)181(288)228-125(53-56-140(192)248)165(272)235-136(82-150(260)261)168(275)216-112(65-95(4)5)79-143(251)219-121(48-38-62-204-184(194)195)162(269)225-123(50-40-64-206-186(198)199)163(270)224-122(49-39-63-205-185(196)197)161(268)217-113(71-108-41-28-26-29-42-108)80-144(252)222-131(72-109-43-30-27-31-44-109)172(279)231-130(69-99(12)13)170(277)233-132(73-114-84-200-91-208-114)167(274)215-110(45-32-35-59-187)77-142(250)221-127(66-96(6)7)176(283)242-155(103(18)25-3)180(287)213-106(21)158(265)214-111(51-57-148(256)257)78-145(253)239-154(102(17)24-2)182(289)237-135(76-117-87-203-94-211-117)177(284)243-156(107(22)246)183(290)212-104(19)70-141(193)249/h26-31,41-44,84-87,91-107,110-113,118-138,152-156,244-246H,23-25,32-40,45-83,88-90,187-190H2,1-22H3,(H2,191,247)(H2,192,248)(H2,193,249)(H,200,208)(H,201,209)(H,202,210)(H,203,211)(H,207,266)(H,212,290)(H,213,287)(H,214,265)(H,215,274)(H,216,275)(H,217,268)(H,218,267)(H,219,251)(H,220,255)(H,221,250)(H,222,252)(H,223,282)(H,224,270)(H,225,269)(H,226,280)(H,227,285)(H,228,288)(H,229,271)(H,230,276)(H,231,279)(H,232,273)(H,233,277)(H,234,278)(H,235,272)(H,236,281)(H,237,289)(H,238,286)(H,239,253)(H,240,254)(H,241,264)(H,242,283)(H,243,284)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H4,194,195,204)(H4,196,197,205)(H4,198,199,206)/t101-,102-,103-,104-,105-,106-,107+,110-,111-,112-,113-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,152-,153-,154-,155-,156-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.320n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246275
PNG
(CHEMBL4073243)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H293N55O49S2/c1-21-97(18)147(237-162(268)116(50-54-142(250)251)214-176(282)134(85-240)233-179(285)144(94(12)13)234-150(256)105(186)83-238)180(286)207-107-44-33-39-104(107)149(255)219-121(65-90(4)5)163(269)215-118(56-63-288-20)160(266)226-127(72-101-80-197-87-204-101)169(275)229-130(75-137(189)243)172(278)220-120(64-89(2)3)151(257)202-82-139(245)206-108(41-27-30-57-183)152(258)225-126(71-100-79-196-86-203-100)168(274)223-124(68-93(10)11)166(272)227-131(76-138(190)244)173(279)232-133(84-239)175(281)216-117(55-62-287-19)159(265)212-114(48-52-140(246)247)156(262)210-112(46-35-61-200-182(194)195)161(267)235-145(95(14)15)177(283)217-115(49-53-141(248)249)158(264)224-125(70-99-78-201-106-40-26-25-38-103(99)106)167(273)222-123(67-92(8)9)164(270)211-111(45-34-60-199-181(192)193)154(260)208-109(42-28-31-58-184)153(259)209-110(43-29-32-59-185)155(261)221-122(66-91(6)7)165(271)213-113(47-51-135(187)241)157(263)230-132(77-143(252)253)174(280)236-146(96(16)17)178(284)231-128(73-102-81-198-88-205-102)170(276)228-129(74-136(188)242)171(277)218-119(148(191)254)69-98-36-23-22-24-37-98/h22-26,36-38,40,78-81,86-97,104-105,107-134,144-147,201,238-240H,21,27-35,39,41-77,82-85,183-186H2,1-20H3,(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H2,191,254)(H,196,203)(H,197,204)(H,198,205)(H,202,257)(H,206,245)(H,207,286)(H,208,260)(H,209,259)(H,210,262)(H,211,270)(H,212,265)(H,213,271)(H,214,282)(H,215,269)(H,216,281)(H,217,283)(H,218,277)(H,219,255)(H,220,278)(H,221,261)(H,222,273)(H,223,274)(H,224,264)(H,225,258)(H,226,266)(H,227,272)(H,228,276)(H,229,275)(H,230,263)(H,231,284)(H,232,279)(H,233,285)(H,234,256)(H,235,267)(H,236,280)(H,237,268)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H4,192,193,199)(H4,194,195,200)/t97-,104-,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,144-,145-,146-,147-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.340n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246245
PNG
(CHEMBL4089035)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C190H307N61O46S2/c1-22-101(16)152(251-170(281)125(58-63-147(260)261)222-156(267)104(19)220-183(294)149(98(10)11)248-154(265)102(17)194)186(297)234-123(56-61-143(197)255)165(276)237-130(76-95(4)5)173(284)231-127(65-74-299-21)168(279)242-135(82-108-89-209-92-217-108)177(288)230-121(54-59-141(195)253)163(274)223-114(50-33-37-69-211-187(201)202)157(268)219-103(18)155(266)221-115(47-30-34-66-191)161(272)240-133(80-106-87-215-112-45-28-26-43-110(106)112)175(286)239-132(78-97(8)9)174(285)243-138(85-145(199)257)180(291)247-140(91-252)182(293)232-126(64-73-298-20)167(278)226-118(51-38-70-212-188(203)204)159(270)227-120(53-40-72-214-190(207)208)169(280)249-150(99(12)13)184(295)233-124(57-62-146(258)259)166(277)241-134(81-107-88-216-113-46-29-27-44-111(107)113)176(287)238-131(77-96(6)7)171(282)228-119(52-39-71-213-189(205)206)160(271)224-116(48-31-35-67-192)158(269)225-117(49-32-36-68-193)162(273)236-129(75-94(2)3)172(283)229-122(55-60-142(196)254)164(275)245-139(86-148(262)263)181(292)250-151(100(14)15)185(296)246-136(83-109-90-210-93-218-109)178(289)244-137(84-144(198)256)179(290)235-128(153(200)264)79-105-41-24-23-25-42-105/h23-29,41-46,87-90,92-104,114-140,149-152,215-216,252H,22,30-40,47-86,91,191-194H2,1-21H3,(H2,195,253)(H2,196,254)(H2,197,255)(H2,198,256)(H2,199,257)(H2,200,264)(H,209,217)(H,210,218)(H,219,268)(H,220,294)(H,221,266)(H,222,267)(H,223,274)(H,224,271)(H,225,269)(H,226,278)(H,227,270)(H,228,282)(H,229,283)(H,230,288)(H,231,284)(H,232,293)(H,233,295)(H,234,297)(H,235,290)(H,236,273)(H,237,276)(H,238,287)(H,239,286)(H,240,272)(H,241,277)(H,242,279)(H,243,285)(H,244,289)(H,245,275)(H,246,296)(H,247,291)(H,248,265)(H,249,280)(H,250,292)(H,251,281)(H,258,259)(H,260,261)(H,262,263)(H4,201,202,211)(H4,203,204,212)(H4,205,206,213)(H4,207,208,214)/t101-,102-,103-,104-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,149-,150-,151-,152-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.340n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246335
PNG
(CHEMBL4093590)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C182H304N54O46/c1-20-94(16)144(234-152(256)103-40-30-49-112(103)206-156(260)115(44-22-24-63-184)205-138(241)83-202-155(259)114(43-21-23-62-183)213-171(275)132(76-142(248)249)228-169(273)129(73-96-77-197-85-203-96)225-167(271)123(67-87(2)3)219-150(254)102-39-29-47-110(102)207-160(264)119(54-58-136(186)239)212-149(253)100-37-27-46-109(100)208-161(265)121(56-60-139(242)243)217-173(277)135(84-237)231-175(279)143(93(14)15)233-147(251)98-35-25-42-107(98)185)176(280)218-120(55-59-137(187)240)162(266)227-131(75-141(246)247)170(274)209-111-48-28-38-101(111)148(252)211-116(51-32-64-199-179(189)190)157(261)214-117(52-33-65-200-180(191)192)158(262)215-118(53-34-66-201-181(193)194)159(263)229-133-81-195-79-105(133)153(257)221-125(69-89(6)7)165(269)223-127(71-91(10)11)164(268)216-122(57-61-140(244)245)163(267)230-134-82-196-80-106(134)154(258)222-126(70-90(8)9)166(270)224-128(72-92(12)13)174(278)236-182(18,19)178(282)232-113-50-31-41-104(113)151(255)220-124(68-88(4)5)168(272)226-130(74-97-78-198-86-204-97)172(276)235-145(95(17)238)177(281)210-108-45-26-36-99(108)146(188)250/h77-78,85-95,98-135,143-145,195-196,237-238H,20-76,79-84,183-185H2,1-19H3,(H2,186,239)(H2,187,240)(H2,188,250)(H,197,203)(H,198,204)(H,202,259)(H,205,241)(H,206,260)(H,207,264)(H,208,265)(H,209,274)(H,210,281)(H,211,252)(H,212,253)(H,213,275)(H,214,261)(H,215,262)(H,216,268)(H,217,277)(H,218,280)(H,219,254)(H,220,255)(H,221,257)(H,222,258)(H,223,269)(H,224,270)(H,225,271)(H,226,272)(H,227,266)(H,228,273)(H,229,263)(H,230,267)(H,231,279)(H,232,282)(H,233,251)(H,234,256)(H,235,276)(H,236,278)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H4,189,190,199)(H4,191,192,200)(H4,193,194,201)/t94-,95+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,143-,144-,145-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.360n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246206
PNG
(CHEMBL4090894)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C194H309N61O46S2/c1-97(2)79-134(176(288)235-128(60-65-147(201)259)169(281)248-143(89-152(266)267)184(296)254-154(101(9)10)187(299)249-140(86-108-93-214-96-222-108)181(293)247-141(87-148(202)260)182(294)239-133(156(204)268)82-104-39-19-18-20-40-104)240-166(278)122(51-27-31-72-197)231-162(274)121(50-26-30-71-196)230-164(276)124(56-37-75-217-192(209)210)234-175(287)135(80-98(3)4)241-179(291)138(84-106-91-220-116-48-24-22-42-110(106)116)244-170(282)129(61-66-150(262)263)238-186(298)153(100(7)8)253-174(286)125(57-38-76-218-193(211)212)233-163(275)123(55-36-74-216-191(207)208)232-172(284)132(69-78-303-17)237-185(297)144(94-256)250-183(295)142(88-149(203)261)246-177(289)136(81-99(5)6)242-178(290)137(83-105-90-219-115-47-23-21-41-109(105)115)243-165(277)120(49-25-29-70-195)226-157(269)103(13)223-161(273)119(52-28-32-73-215-190(205)206)229-168(280)127(59-64-146(200)258)236-180(292)139(85-107-92-213-95-221-107)245-173(285)131(68-77-302-16)228-160(272)113-45-35-53-117(113)224-167(279)126(58-63-145(199)257)227-159(271)112-44-34-54-118(112)225-171(283)130(62-67-151(264)265)251-189(301)194(14,15)255-188(300)155(102(11)12)252-158(270)111-43-33-46-114(111)198/h18-24,39-42,47-48,90-93,95-103,111-114,117-144,153-155,219-220,256H,25-38,43-46,49-89,94,195-198H2,1-17H3,(H2,199,257)(H2,200,258)(H2,201,259)(H2,202,260)(H2,203,261)(H2,204,268)(H,213,221)(H,214,222)(H,223,273)(H,224,279)(H,225,283)(H,226,269)(H,227,271)(H,228,272)(H,229,280)(H,230,276)(H,231,274)(H,232,284)(H,233,275)(H,234,287)(H,235,288)(H,236,292)(H,237,297)(H,238,298)(H,239,294)(H,240,278)(H,241,291)(H,242,290)(H,243,277)(H,244,282)(H,245,285)(H,246,289)(H,247,293)(H,248,281)(H,249,299)(H,250,295)(H,251,301)(H,252,270)(H,253,286)(H,254,296)(H,255,300)(H,262,263)(H,264,265)(H,266,267)(H4,205,206,215)(H4,207,208,216)(H4,209,210,217)(H4,211,212,218)/t103-,111-,112-,113-,114-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,153-,154-,155-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246205
PNG
(CHEMBL4106300)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1/C196H319N61O46S2/c1-22-107(16)164(257-178(289)135(58-63-159(272)273)238-167(278)110(19)226-189(300)162(105(12)13)255-165(276)108(17)200)192(303)245-134(57-61-149(203)261)175(286)247-139(77-102(6)7)183(294)244-136(65-74-305-21)176(287)249-142(82-120-95-215-98-223-120)185(296)243-133(56-60-148(202)260)174(285)239-128(50-33-37-69-217-193(207)208)168(279)225-109(18)166(277)237-129(49-32-36-68-199)170(281)231-118(80-112-93-221-124-46-28-26-44-122(112)124)88-156(268)235-137(75-100(2)3)180(291)251-145(92-152(206)264)187(298)253-146(97-258)188(299)228-116(64-73-304-20)87-154(266)234-127(51-38-70-218-194(209)210)172(283)240-131(53-40-72-220-196(213)214)177(288)256-163(106(14)15)190(301)229-115(54-62-158(270)271)86-155(267)236-141(81-113-94-222-125-47-29-27-45-123(113)125)184(295)248-140(78-103(8)9)181(292)241-130(52-39-71-219-195(211)212)169(280)227-114(43-30-34-66-197)85-153(265)233-126(48-31-35-67-198)173(284)246-138(76-101(4)5)182(293)242-132(55-59-147(201)259)171(282)232-119(90-160(274)275)89-157(269)254-161(104(10)11)191(302)252-143(83-121-96-216-99-224-121)186(297)250-144(91-151(205)263)179(290)230-117(84-150(204)262)79-111-41-24-23-25-42-111/h23-29,41-42,44-47,93-96,98-110,114-119,126-146,161-164,221-222,258H,22,30-40,43,48-92,97,197-200H2,1-21H3,(H2,201,259)(H2,202,260)(H2,203,261)(H2,204,262)(H2,205,263)(H2,206,264)(H,215,223)(H,216,224)(H,225,279)(H,226,300)(H,227,280)(H,228,299)(H,229,301)(H,230,290)(H,231,281)(H,232,282)(H,233,265)(H,234,266)(H,235,268)(H,236,267)(H,237,277)(H,238,278)(H,239,285)(H,240,283)(H,241,292)(H,242,293)(H,243,296)(H,244,294)(H,245,303)(H,246,284)(H,247,286)(H,248,295)(H,249,287)(H,250,297)(H,251,291)(H,252,302)(H,253,298)(H,254,269)(H,255,276)(H,256,288)(H,257,289)(H,270,271)(H,272,273)(H,274,275)(H4,207,208,217)(H4,209,210,218)(H4,211,212,219)(H4,213,214,220)/t107-,108-,109-,110-,114-,115-,116-,117-,118-,119+,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,161-,162-,163-,164-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.440n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246363
PNG
(CHEMBL4097878)
Show SMILES CSCC[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C188H309N61O42S/c1-91(2)73-130(234-156(264)107-41-30-51-116(107)219-161(269)120(45-19-22-66-189)224-151(259)97(13)217-160(268)119(47-21-24-68-210-184(198)199)229-167(275)127(59-63-143(194)253)233-175(283)134(77-99-82-208-89-215-99)238-169(277)129(65-72-292-16)228-155(263)105-39-28-49-114(105)220-165(273)125(57-61-141(192)251)227-154(262)104-38-27-50-115(104)222-168(276)128(60-64-146(256)257)245-183(291)188(14,15)249-182(290)149(96(11)12)247-152(260)102-36-25-43-111(102)191)173(281)239-137(80-145(196)255)178(286)244-140(88-250)179(287)223-117-52-29-40-106(117)153(261)225-122(54-32-69-211-185(200)201)162(270)230-124(56-34-71-213-187(204)205)170(278)248-148(95(9)10)181(289)243-139-87-207-85-110(139)159(267)235-133(76-98-81-214-112-44-18-17-35-101(98)112)174(282)237-132(75-93(5)6)171(279)231-123(55-33-70-212-186(202)203)164(272)242-138-86-206-84-109(138)158(266)226-121(46-20-23-67-190)163(271)236-131(74-92(3)4)172(280)232-126(58-62-142(193)252)166(274)221-118-53-31-42-108(118)157(265)246-147(94(7)8)180(288)241-135(78-100-83-209-90-216-100)176(284)240-136(79-144(195)254)177(285)218-113-48-26-37-103(113)150(197)258/h17-18,35,44,81-83,89-97,102-111,113-140,147-149,206-207,214,250H,19-34,36-43,45-80,84-88,189-191H2,1-16H3,(H2,192,251)(H2,193,252)(H2,194,253)(H2,195,254)(H2,196,255)(H2,197,258)(H,208,215)(H,209,216)(H,217,268)(H,218,285)(H,219,269)(H,220,273)(H,221,274)(H,222,276)(H,223,287)(H,224,259)(H,225,261)(H,226,266)(H,227,262)(H,228,263)(H,229,275)(H,230,270)(H,231,279)(H,232,280)(H,233,283)(H,234,264)(H,235,267)(H,236,271)(H,237,282)(H,238,277)(H,239,281)(H,240,284)(H,241,288)(H,242,272)(H,243,289)(H,244,286)(H,245,291)(H,246,265)(H,247,260)(H,248,278)(H,249,290)(H,256,257)(H4,198,199,210)(H4,200,201,211)(H4,202,203,212)(H4,204,205,213)/t97-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.480n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246370
PNG
(CHEMBL4059512)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C184H307N61O42S/c1-21-95(16)146(245-166(273)123(56-60-142(252)253)220-150(257)98(19)214-177(284)143(92(10)11)242-148(255)96(17)187)180(287)229-122(55-59-139(190)249)163(270)233-127(71-90(6)7)169(276)228-124(61-68-288-20)164(271)235-130(74-100-79-204-86-211-100)172(279)227-121(54-58-138(189)248)162(269)223-114(45-26-29-64-206-181(194)195)156(263)213-97(18)149(256)219-115(43-24-27-62-185)157(264)216-111-47-32-40-105(111)152(259)230-125(69-88(2)3)170(277)236-133(77-141(192)251)175(282)241-136(85-246)176(283)218-112-48-31-39-104(112)151(258)221-117(50-34-65-207-182(196)197)158(265)224-119(52-36-67-209-184(200)201)165(272)244-145(94(14)15)179(286)240-135-84-203-82-108(135)155(262)231-129(73-99-78-210-109-42-23-22-37-102(99)109)171(278)234-128(72-91(8)9)167(274)225-118(51-35-66-208-183(198)199)160(267)239-134-83-202-81-107(134)154(261)222-116(44-25-28-63-186)159(266)232-126(70-89(4)5)168(275)226-120(53-57-137(188)247)161(268)217-113-49-33-41-106(113)153(260)243-144(93(12)13)178(285)238-131(75-101-80-205-87-212-101)173(280)237-132(76-140(191)250)174(281)215-110-46-30-38-103(110)147(193)254/h22-23,37,42,78-80,86-98,103-108,110-136,143-146,202-203,210,246H,21,24-36,38-41,43-77,81-85,185-187H2,1-20H3,(H2,188,247)(H2,189,248)(H2,190,249)(H2,191,250)(H2,192,251)(H2,193,254)(H,204,211)(H,205,212)(H,213,263)(H,214,284)(H,215,281)(H,216,264)(H,217,268)(H,218,283)(H,219,256)(H,220,257)(H,221,258)(H,222,261)(H,223,269)(H,224,265)(H,225,274)(H,226,275)(H,227,279)(H,228,276)(H,229,287)(H,230,259)(H,231,262)(H,232,266)(H,233,270)(H,234,278)(H,235,271)(H,236,277)(H,237,280)(H,238,285)(H,239,267)(H,240,286)(H,241,282)(H,242,255)(H,243,260)(H,244,272)(H,245,273)(H,252,253)(H4,194,195,206)(H4,196,197,207)(H4,198,199,208)(H4,200,201,209)/t95-,96-,97-,98-,103-,104-,105-,106-,107-,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,143-,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.510n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246338
PNG
(CHEMBL4063242)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C185H300N56O44/c1-17-94(12)146(179(282)210-97(15)151(254)212-114-50-32-44-108(114)156(259)239-148(96(14)19-3)181(284)233-133(75-102-80-202-89-209-102)176(279)241-149(98(16)243)182(285)217-113-49-28-40-104(113)150(191)253)240-175(278)129(71-92(8)9)226-158(261)111-82-199-84-137(111)235-172(275)132(74-101-79-201-88-208-101)230-169(272)128(70-91(6)7)228-170(273)130(72-99-37-21-20-22-38-99)227-159(262)110-81-198-83-136(110)234-164(267)123(57-36-68-205-185(196)197)222-163(266)122(56-35-67-204-184(194)195)221-162(265)121(55-34-66-203-183(192)193)218-153(256)106-42-30-53-117(106)216-173(276)134(76-143(249)250)231-167(270)125(59-62-140(190)245)224-180(283)147(95(13)18-2)238-157(260)109-45-33-54-118(109)213-161(264)120(48-24-26-65-187)211-141(246)85-206-160(263)119(47-23-25-64-186)220-174(277)135(77-144(251)252)232-171(274)131(73-100-78-200-87-207-100)229-168(271)127(69-90(4)5)225-155(258)107-43-31-52-116(107)214-165(268)124(58-61-139(189)244)219-154(257)105-41-29-51-115(105)215-166(269)126(60-63-142(247)248)223-177(280)138(86-242)236-178(281)145(93(10)11)237-152(255)103-39-27-46-112(103)188/h20-22,37-38,78-80,87-98,103-138,145-149,198-199,242-243H,17-19,23-36,39-77,81-86,186-188H2,1-16H3,(H2,189,244)(H2,190,245)(H2,191,253)(H,200,207)(H,201,208)(H,202,209)(H,206,263)(H,210,282)(H,211,246)(H,212,254)(H,213,264)(H,214,268)(H,215,269)(H,216,276)(H,217,285)(H,218,256)(H,219,257)(H,220,277)(H,221,265)(H,222,266)(H,223,280)(H,224,283)(H,225,258)(H,226,261)(H,227,262)(H,228,273)(H,229,271)(H,230,272)(H,231,270)(H,232,274)(H,233,284)(H,234,267)(H,235,275)(H,236,281)(H,237,255)(H,238,260)(H,239,259)(H,240,278)(H,241,279)(H,247,248)(H,249,250)(H,251,252)(H4,192,193,203)(H4,194,195,204)(H4,196,197,205)/t94-,95-,96-,97-,98+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,145-,146-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.510n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246384
PNG
(CHEMBL4069902)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C194H311N61O46S2/c1-20-103(14)155(254-173(285)129(62-67-150(264)265)250-189(301)194(16,17)255-188(300)154(102(12)13)251-158(270)112-45-36-47-114(112)198)187(299)237-127(60-65-146(201)259)166(278)224-117-54-37-46-113(117)159(271)226-130(68-77-302-18)171(283)244-138(85-108-92-213-95-221-108)179(291)234-125(58-63-144(199)257)167(279)227-118(53-31-35-73-215-190(205)206)160(272)223-104(15)157(269)225-119(50-28-32-70-195)164(276)242-136(83-106-90-219-115-48-26-24-43-110(106)115)177(289)241-135(81-99(6)7)176(288)245-141(88-148(203)261)182(294)249-143(94-256)184(296)235-131(69-78-303-19)170(282)230-122(55-38-74-216-191(207)208)162(274)231-124(57-40-76-218-193(211)212)172(284)252-152(100(8)9)185(297)236-128(61-66-149(262)263)169(281)243-137(84-107-91-220-116-49-27-25-44-111(107)116)178(290)240-134(80-98(4)5)174(286)232-123(56-39-75-217-192(209)210)163(275)228-120(51-29-33-71-196)161(273)229-121(52-30-34-72-197)165(277)239-133(79-97(2)3)175(287)233-126(59-64-145(200)258)168(280)247-142(89-151(266)267)183(295)253-153(101(10)11)186(298)248-139(86-109-93-214-96-222-109)180(292)246-140(87-147(202)260)181(293)238-132(156(204)268)82-105-41-22-21-23-42-105/h21-27,41-44,48-49,90-93,95-104,112-114,117-143,152-155,219-220,256H,20,28-40,45-47,50-89,94,195-198H2,1-19H3,(H2,199,257)(H2,200,258)(H2,201,259)(H2,202,260)(H2,203,261)(H2,204,268)(H,213,221)(H,214,222)(H,223,272)(H,224,278)(H,225,269)(H,226,271)(H,227,279)(H,228,275)(H,229,273)(H,230,282)(H,231,274)(H,232,286)(H,233,287)(H,234,291)(H,235,296)(H,236,297)(H,237,299)(H,238,293)(H,239,277)(H,240,290)(H,241,289)(H,242,276)(H,243,281)(H,244,283)(H,245,288)(H,246,292)(H,247,280)(H,248,298)(H,249,294)(H,250,301)(H,251,270)(H,252,284)(H,253,295)(H,254,285)(H,255,300)(H,262,263)(H,264,265)(H,266,267)(H4,205,206,215)(H4,207,208,216)(H4,209,210,217)(H4,211,212,218)/t103-,104-,112-,113-,114-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,152-,153-,154-,155-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.520n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246420
PNG
(CHEMBL4106304)
Show SMILES CC[C@H](C)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C182H296N58O44/c1-20-93(14)143(176(281)209-97(18)149(254)211-111-46-32-41-106(111)151(256)238-145(95(16)22-3)178(283)232-130(71-103-77-200-87-208-103)173(278)240-146(98(19)242)179(284)214-110-45-30-39-104(110)147(188)252)239-172(277)125(66-91(10)11)222-153(258)109-79-196-81-134(109)234-169(274)129(70-102-76-199-86-207-102)229-165(270)124(65-90(8)9)226-166(271)126(67-99-37-24-23-25-38-99)223-154(259)108-78-195-80-133(108)233-159(264)118(51-36-62-203-182(193)194)218-158(263)117(50-35-61-202-181(191)192)217-157(262)116(49-34-60-201-180(189)190)215-150(255)105-40-31-47-112(105)213-170(275)131(72-140(248)249)230-161(266)120(53-56-137(187)244)221-177(282)144(94(15)21-2)237-152(257)107-42-33-48-113(107)212-156(261)115(44-27-29-59-184)210-138(245)82-204-155(260)114(43-26-28-58-183)216-171(276)132(73-141(250)251)231-168(273)128(69-101-75-198-85-206-101)228-164(269)123(64-89(6)7)225-163(268)122(63-88(4)5)224-160(265)119(52-55-136(186)243)219-167(272)127(68-100-74-197-84-205-100)227-162(267)121(54-57-139(246)247)220-174(279)135(83-241)235-175(280)142(92(12)13)236-148(253)96(17)185/h23-25,37-38,74-77,84-98,104-135,142-146,195-196,241-242H,20-22,26-36,39-73,78-83,183-185H2,1-19H3,(H2,186,243)(H2,187,244)(H2,188,252)(H,197,205)(H,198,206)(H,199,207)(H,200,208)(H,204,260)(H,209,281)(H,210,245)(H,211,254)(H,212,261)(H,213,275)(H,214,284)(H,215,255)(H,216,276)(H,217,262)(H,218,263)(H,219,272)(H,220,279)(H,221,282)(H,222,258)(H,223,259)(H,224,265)(H,225,268)(H,226,271)(H,227,267)(H,228,269)(H,229,270)(H,230,266)(H,231,273)(H,232,283)(H,233,264)(H,234,274)(H,235,280)(H,236,253)(H,237,257)(H,238,256)(H,239,277)(H,240,278)(H,246,247)(H,248,249)(H,250,251)(H4,189,190,201)(H4,191,192,202)(H4,193,194,203)/t93-,94-,95-,96-,97-,98+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,142-,143+,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.650n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246385
PNG
(CHEMBL4083799)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C183H297N55O45S/c1-18-94(16)148(238-166(268)121(54-58-144(249)250)219-177(279)136(84-240)234-180(282)146(92(12)13)235-150(252)99-34-25-40-107(99)186)181(283)220-119(52-56-138(188)242)162(264)210-110-45-27-36-101(110)152(254)215-122(59-64-284-17)164(266)226-128(70-96-76-199-85-205-96)171(273)229-131(73-140(190)244)174(276)223-123(65-87(2)3)157(259)204-82-142(246)207-114(42-21-23-60-184)158(260)209-111-46-29-38-103(111)153(255)221-124(66-88(4)5)169(271)227-132(74-141(191)245)175(277)233-135(83-239)176(278)212-112-47-28-37-102(112)151(253)214-120(53-57-143(247)248)163(265)216-117(50-32-63-202-183(195)196)165(267)237-147(93(14)15)179(281)232-134-81-198-79-106(134)156(258)222-127(69-95-75-203-108-41-20-19-33-98(95)108)170(272)225-126(68-90(8)9)167(269)217-116(49-31-62-201-182(193)194)160(262)231-133-80-197-78-105(133)155(257)213-115(43-22-24-61-185)159(261)224-125(67-89(6)7)168(270)218-118(51-55-137(187)241)161(263)211-113-48-30-39-104(113)154(256)236-145(91(10)11)178(280)230-129(71-97-77-200-86-206-97)172(274)228-130(72-139(189)243)173(275)208-109-44-26-35-100(109)149(192)251/h19-20,33,41,75-77,85-94,99-107,109-136,145-148,197-198,203,239-240H,18,21-32,34-40,42-74,78-84,184-186H2,1-17H3,(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,251)(H,199,205)(H,200,206)(H,204,259)(H,207,246)(H,208,275)(H,209,260)(H,210,264)(H,211,263)(H,212,278)(H,213,257)(H,214,253)(H,215,254)(H,216,265)(H,217,269)(H,218,270)(H,219,279)(H,220,283)(H,221,255)(H,222,258)(H,223,276)(H,224,261)(H,225,272)(H,226,266)(H,227,271)(H,228,274)(H,229,273)(H,230,280)(H,231,262)(H,232,281)(H,233,277)(H,234,282)(H,235,252)(H,236,256)(H,237,267)(H,238,268)(H,247,248)(H,249,250)(H4,193,194,201)(H4,195,196,202)/t94-,99-,100-,101-,102-,103-,104-,105-,106-,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,145-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.710n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246425
PNG
(CHEMBL4106302)
Show SMILES CSCC[C@@H](CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C
Show InChI InChI=1/C200H321N61O46S2/c1-103(2)79-142(238-160(272)91-117(83-111-96-225-127-48-23-21-42-121(111)127)234-174(286)134(51-27-31-72-203)242-168(280)109(13)229-172(284)133(52-28-32-73-221-196(211)212)245-179(291)139(61-65-153(207)265)249-188(300)146(85-119-98-219-101-227-119)252-181(293)141(69-78-309-17)244-171(283)125-46-35-53-129(125)240-178(290)138(60-64-152(206)264)243-170(282)124-45-34-54-130(124)241-180(292)140(62-67-163(276)277)257-195(307)200(14,15)261-194(306)167(108(11)12)259-169(281)123-44-33-47-126(123)204)184(296)254-149(95-156(210)268)190(302)256-150(100-262)191(303)231-115(68-77-308-16)90-158(270)237-132(55-36-74-222-197(213)214)176(288)246-136(57-38-76-224-199(217)218)182(294)260-166(107(9)10)192(304)232-114(58-66-162(274)275)89-159(271)239-145(84-112-97-226-128-49-24-22-43-122(112)128)187(299)251-144(81-105(5)6)185(297)247-135(56-37-75-223-198(215)216)173(285)230-113(41-25-29-70-201)88-157(269)236-131(50-26-30-71-202)177(289)250-143(80-104(3)4)186(298)248-137(59-63-151(205)263)175(287)235-118(93-164(278)279)92-161(273)258-165(106(7)8)193(305)255-147(86-120-99-220-102-228-120)189(301)253-148(94-155(209)267)183(295)233-116(87-154(208)266)82-110-39-19-18-20-40-110/h18-24,39-40,42-43,48-49,96-99,101-109,113-118,123-126,129-150,165-167,225-226,262H,25-38,41,44-47,50-95,100,201-204H2,1-17H3,(H2,205,263)(H2,206,264)(H2,207,265)(H2,208,266)(H2,209,267)(H2,210,268)(H,219,227)(H,220,228)(H,229,284)(H,230,285)(H,231,303)(H,232,304)(H,233,295)(H,234,286)(H,235,287)(H,236,269)(H,237,270)(H,238,272)(H,239,271)(H,240,290)(H,241,292)(H,242,280)(H,243,282)(H,244,283)(H,245,291)(H,246,288)(H,247,297)(H,248,298)(H,249,300)(H,250,289)(H,251,299)(H,252,293)(H,253,301)(H,254,296)(H,255,305)(H,256,302)(H,257,307)(H,258,273)(H,259,281)(H,260,294)(H,261,306)(H,274,275)(H,276,277)(H,278,279)(H4,211,212,221)(H4,213,214,222)(H4,215,216,223)(H4,217,218,224)/t109-,113-,114-,115-,116-,117-,118+,123-,124-,125-,126-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,165-,166-,167-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.790n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246369
PNG
(CHEMBL4106301)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1/C200H323N61O46S2/c1-20-109(14)167(260-181(293)139(62-67-162(276)277)256-195(307)200(16,17)261-194(306)166(108(12)13)258-169(281)124-46-36-48-126(124)204)193(305)248-138(61-65-152(207)265)177(289)240-129-54-37-47-125(129)170(282)242-140(69-78-309-19)179(291)251-145(85-120-98-219-101-227-120)187(299)247-137(60-64-151(206)264)178(290)243-132(53-31-35-73-221-196(211)212)171(283)229-110(15)168(280)241-133(52-30-34-72-203)173(285)234-118(83-112-96-225-127-49-26-24-44-122(112)127)91-159(272)238-141(79-103(2)3)183(295)253-148(95-155(210)268)189(301)255-149(100-262)190(302)231-116(68-77-308-18)90-157(270)237-131(55-38-74-222-197(213)214)175(287)244-135(57-40-76-224-199(217)218)180(292)259-165(107(10)11)191(303)232-115(58-66-161(274)275)89-158(271)239-144(84-113-97-226-128-50-27-25-45-123(113)128)186(298)250-143(81-105(6)7)184(296)245-134(56-39-75-223-198(215)216)172(284)230-114(43-28-32-70-201)88-156(269)236-130(51-29-33-71-202)176(288)249-142(80-104(4)5)185(297)246-136(59-63-150(205)263)174(286)235-119(93-163(278)279)92-160(273)257-164(106(8)9)192(304)254-146(86-121-99-220-102-228-121)188(300)252-147(94-154(209)267)182(294)233-117(87-153(208)266)82-111-41-22-21-23-42-111/h21-27,41-42,44-45,49-50,96-99,101-110,114-119,124-126,129-149,164-167,225-226,262H,20,28-40,43,46-48,51-95,100,201-204H2,1-19H3,(H2,205,263)(H2,206,264)(H2,207,265)(H2,208,266)(H2,209,267)(H2,210,268)(H,219,227)(H,220,228)(H,229,283)(H,230,284)(H,231,302)(H,232,303)(H,233,294)(H,234,285)(H,235,286)(H,236,269)(H,237,270)(H,238,272)(H,239,271)(H,240,289)(H,241,280)(H,242,282)(H,243,290)(H,244,287)(H,245,296)(H,246,297)(H,247,299)(H,248,305)(H,249,288)(H,250,298)(H,251,291)(H,252,300)(H,253,295)(H,254,304)(H,255,301)(H,256,307)(H,257,273)(H,258,281)(H,259,292)(H,260,293)(H,261,306)(H,274,275)(H,276,277)(H,278,279)(H4,211,212,221)(H4,213,214,222)(H4,215,216,223)(H4,217,218,224)/t109-,110-,114-,115-,116-,117-,118-,119+,124-,125-,126-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,164-,165-,166-,167-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.830n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269978
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.920n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization


J Med Chem 53: 4332-53 (2010)


Article DOI: 10.1021/jm9018756
BindingDB Entry DOI: 10.7270/Q21R6QPF
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246295
PNG
(CHEMBL4060554)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)CC(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)148(238-163(271)116(48-53-143(253)254)216-176(284)133(85-241)234-179(287)145(94(12)13)235-150(258)105(186)83-239)180(288)219-112(44-49-134(187)242)152(260)207-100(63-89(2)3)73-139(247)208-117(54-61-289-19)160(268)227-126(71-102-80-198-87-205-102)169(277)230-129(75-137(190)245)172(280)221-120(64-90(4)5)151(259)203-82-140(248)209-107(39-27-30-56-183)153(261)226-125(70-101-79-197-86-204-101)168(276)224-123(67-93(10)11)166(274)228-130(76-138(191)246)173(281)233-132(84-240)175(283)217-118(55-62-290-20)161(269)214-114(46-51-141(249)250)157(265)212-111(43-34-60-201-182(195)196)162(270)236-146(95(14)15)177(285)218-115(47-52-142(251)252)159(267)225-124(69-99-78-202-106-38-26-25-37-104(99)106)167(275)223-122(66-92(8)9)164(272)213-110(42-33-59-200-181(193)194)155(263)210-108(40-28-31-57-184)154(262)211-109(41-29-32-58-185)156(264)222-121(65-91(6)7)165(273)215-113(45-50-135(188)243)158(266)231-131(77-144(255)256)174(282)237-147(96(16)17)178(286)232-127(72-103-81-199-88-206-103)170(278)229-128(74-136(189)244)171(279)220-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,100,105,107-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,260)(H,208,247)(H,209,248)(H,210,263)(H,211,262)(H,212,265)(H,213,272)(H,214,269)(H,215,273)(H,216,284)(H,217,283)(H,218,285)(H,219,288)(H,220,279)(H,221,280)(H,222,264)(H,223,275)(H,224,276)(H,225,267)(H,226,261)(H,227,268)(H,228,274)(H,229,278)(H,230,277)(H,231,266)(H,232,286)(H,233,281)(H,234,287)(H,235,258)(H,236,270)(H,237,282)(H,238,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,100-,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269977
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246364
PNG
(CHEMBL4090161)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C188H311N61O42S/c1-19-97(14)149(248-169(277)127(60-64-145(256)257)244-183(291)188(16,17)249-182(290)148(96(12)13)246-152(260)103-38-28-44-111(103)191)181(289)232-126(59-63-142(194)253)165(273)220-114-50-30-40-105(114)154(262)226-128(65-72-292-18)167(275)237-133(77-100-82-208-89-215-100)174(282)231-125(58-62-141(193)252)166(274)227-118(48-24-27-68-210-184(198)199)159(267)217-98(15)151(259)223-119(46-22-25-66-189)160(268)219-115-51-32-42-107(115)155(263)233-129(73-91(2)3)172(280)238-136(80-144(196)255)177(285)243-139(88-250)178(286)222-116-52-31-41-106(116)153(261)224-121(54-34-69-211-185(200)201)161(269)228-123(56-36-71-213-187(204)205)168(276)247-147(95(10)11)180(288)242-138-87-207-85-110(138)158(266)234-132(76-99-81-214-112-45-21-20-37-102(99)112)173(281)236-131(75-93(6)7)170(278)229-122(55-35-70-212-186(202)203)163(271)241-137-86-206-84-109(137)157(265)225-120(47-23-26-67-190)162(270)235-130(74-92(4)5)171(279)230-124(57-61-140(192)251)164(272)221-117-53-33-43-108(117)156(264)245-146(94(8)9)179(287)240-134(78-101-83-209-90-216-101)175(283)239-135(79-143(195)254)176(284)218-113-49-29-39-104(113)150(197)258/h20-21,37,45,81-83,89-98,103-111,113-139,146-149,206-207,214,250H,19,22-36,38-44,46-80,84-88,189-191H2,1-18H3,(H2,192,251)(H2,193,252)(H2,194,253)(H2,195,254)(H2,196,255)(H2,197,258)(H,208,215)(H,209,216)(H,217,267)(H,218,284)(H,219,268)(H,220,273)(H,221,272)(H,222,286)(H,223,259)(H,224,261)(H,225,265)(H,226,262)(H,227,274)(H,228,269)(H,229,278)(H,230,279)(H,231,282)(H,232,289)(H,233,263)(H,234,266)(H,235,270)(H,236,281)(H,237,275)(H,238,280)(H,239,283)(H,240,287)(H,241,271)(H,242,288)(H,243,285)(H,244,291)(H,245,264)(H,246,260)(H,247,276)(H,248,277)(H,249,290)(H,256,257)(H4,198,199,210)(H4,200,201,211)(H4,202,203,212)(H4,204,205,213)/t97-,98-,103-,104-,105-,106-,107-,108-,109-,110-,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,146-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.80n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246248
PNG
(CHEMBL4106298)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1/C195H309N55O49S2/c1-19-106(16)166(250-178(284)133(56-61-161(269)270)235-189(295)146(96-252)246-192(298)165(105(14)15)248-167(273)120-42-33-44-122(120)199)193(299)236-132(54-58-148(201)254)175(281)230-125-49-34-43-121(125)168(274)231-134(63-70-301-18)176(282)240-140(78-116-92-210-97-217-116)184(290)243-143(88-151(204)257)186(292)237-135(71-99(2)3)169(275)216-94-158(264)227-126(47-28-31-65-197)170(276)223-114(76-108-90-214-123-45-25-23-40-118(108)123)84-156(262)228-136(72-100(4)5)180(286)242-144(89-152(205)258)187(293)245-145(95-251)188(294)220-112(62-69-300-17)83-154(260)226-130(55-60-160(267)268)174(280)232-129(51-36-68-213-195(208)209)177(283)249-164(104(12)13)190(296)221-111(52-59-159(265)266)82-155(261)229-139(77-109-91-215-124-46-26-24-41-119(109)124)183(289)239-138(74-102(8)9)181(287)233-128(50-35-67-212-194(206)207)171(277)219-110(39-27-30-64-196)81-153(259)225-127(48-29-32-66-198)173(279)238-137(73-101(6)7)182(288)234-131(53-57-147(200)253)172(278)224-115(86-162(271)272)85-157(263)247-163(103(10)11)191(297)244-141(79-117-93-211-98-218-117)185(291)241-142(87-150(203)256)179(285)222-113(80-149(202)255)75-107-37-21-20-22-38-107/h20-26,37-38,40-41,45-46,90-93,97-106,110-115,120-122,125-146,163-166,214-215,251-252H,19,27-36,39,42-44,47-89,94-96,196-199H2,1-18H3,(H2,200,253)(H2,201,254)(H2,202,255)(H2,203,256)(H2,204,257)(H2,205,258)(H,210,217)(H,211,218)(H,216,275)(H,219,277)(H,220,294)(H,221,296)(H,222,285)(H,223,276)(H,224,278)(H,225,259)(H,226,260)(H,227,264)(H,228,262)(H,229,261)(H,230,281)(H,231,274)(H,232,280)(H,233,287)(H,234,288)(H,235,295)(H,236,299)(H,237,292)(H,238,279)(H,239,289)(H,240,282)(H,241,291)(H,242,286)(H,243,290)(H,244,297)(H,245,293)(H,246,298)(H,247,263)(H,248,273)(H,249,283)(H,250,284)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H4,206,207,212)(H4,208,209,213)/t106-,110-,111-,112-,113-,114-,115+,120-,121-,122-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,163-,164-,165-,166-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.80n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50331022
PNG
((7S,10S,13S,16S,19S,22S,25S,28S)-13-((1H-imidazol-...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O
Show InChI InChI=1/C59H103N19O15/c1-12-14-17-35(47(84)74-40(27-33-28-66-29-68-33)52(89)71-36(19-22-41(60)79)48(85)69-34(46(62)83)18-15-16-25-67-57(63)64)70-51(88)39(26-30(3)4)73-49(86)37(20-23-42(61)80)72-53(90)45(32(7)13-2)76-50(87)38(21-24-43(81)82)75-56(93)59(10,11)78-54(91)44(31(5)6)77-55(92)58(8,9)65/h28-32,34-40,44-45H,12-27,65H2,1-11H3,(H2,60,79)(H2,61,80)(H2,62,83)(H,66,68)(H,69,85)(H,70,88)(H,71,89)(H,72,90)(H,73,86)(H,74,84)(H,75,93)(H,76,87)(H,77,92)(H,78,91)(H,81,82)(H4,63,64,67)/t32-,34-,35-,36-,37-,38-,39-,40-,44-,45-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.40n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)


Article DOI: 10.1021/jm1008264
BindingDB Entry DOI: 10.7270/Q2GM87KQ
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246296
PNG
(CHEMBL4098506)
Show SMILES CC[C@H](C)[C@@H](CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)118(219-158(266)114(47-52-143(251)252)215-177(285)134(85-241)235-180(288)146(94(12)13)236-150(258)104(186)83-239)76-140(247)207-111(44-49-135(187)242)156(264)223-122(65-91(6)7)166(274)216-117(55-62-290-20)162(270)228-127(71-101-80-198-87-205-101)170(278)231-130(74-138(190)245)173(281)221-120(63-89(2)3)151(259)203-82-141(248)208-106(39-27-30-56-183)152(260)227-126(70-100-79-197-86-204-100)169(277)225-124(67-93(10)11)167(275)229-131(75-139(191)246)174(282)234-133(84-240)176(284)217-116(54-61-289-19)161(269)213-113(46-51-142(249)250)157(265)211-110(43-34-60-201-182(195)196)163(271)237-147(95(14)15)178(286)218-115(48-53-144(253)254)160(268)226-125(69-99-78-202-105-38-26-25-37-103(99)105)168(276)224-123(66-92(8)9)164(272)212-109(42-33-59-200-181(193)194)154(262)209-107(40-28-31-57-184)153(261)210-108(41-29-32-58-185)155(263)222-121(64-90(4)5)165(273)214-112(45-50-136(188)243)159(267)232-132(77-145(255)256)175(283)238-148(96(16)17)179(287)233-128(72-102-81-199-88-206-102)171(279)230-129(73-137(189)244)172(280)220-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,104,106-134,146-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,247)(H,208,248)(H,209,262)(H,210,261)(H,211,265)(H,212,272)(H,213,269)(H,214,273)(H,215,285)(H,216,274)(H,217,284)(H,218,286)(H,219,266)(H,220,280)(H,221,281)(H,222,263)(H,223,264)(H,224,276)(H,225,277)(H,226,268)(H,227,260)(H,228,270)(H,229,275)(H,230,279)(H,231,278)(H,232,267)(H,233,287)(H,234,282)(H,235,288)(H,236,258)(H,237,271)(H,238,283)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.60n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246386
PNG
(CHEMBL4059923)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C184H292N56O49S2/c1-90(2)67-123(224-175(282)132(77-140(192)246)233-172(279)129(74-100-82-200-88-207-100)230-165(272)120(58-65-290-15)213-153(260)105-38-30-45-109(105)210-159(266)115(48-53-137(189)243)212-152(259)104-37-29-44-108(104)211-160(267)117(50-55-143(249)250)220-179(286)136(86-242)237-182(289)147(94(9)10)238-151(258)103-36-28-39-106(103)188)154(261)205-84-142(248)209-110(41-22-25-60-185)155(262)229-128(73-99-81-199-87-206-99)171(278)227-126(70-93(7)8)169(276)231-133(78-141(193)247)176(283)236-135(85-241)178(285)221-121(59-66-291-16)164(271)218-118(51-56-144(251)252)161(268)216-114(47-32-64-203-184(197)198)166(273)239-148(95(11)12)180(287)222-119(52-57-145(253)254)163(270)228-127(72-98-80-204-107-40-21-20-35-102(98)107)170(277)226-125(69-92(5)6)167(274)217-113(46-31-63-202-183(195)196)157(264)214-111(42-23-26-61-186)156(263)215-112(43-24-27-62-187)158(265)225-124(68-91(3)4)168(275)219-116(49-54-138(190)244)162(269)234-134(79-146(255)256)177(284)240-149(96(13)14)181(288)235-130(75-101-83-201-89-208-101)173(280)232-131(76-139(191)245)174(281)223-122(150(194)257)71-97-33-18-17-19-34-97/h17-21,33-35,40,80-83,87-96,103-106,108-136,147-149,204,241-242H,22-32,36-39,41-79,84-86,185-188H2,1-16H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,261)(H,209,248)(H,210,266)(H,211,267)(H,212,259)(H,213,260)(H,214,264)(H,215,263)(H,216,268)(H,217,274)(H,218,271)(H,219,275)(H,220,286)(H,221,285)(H,222,287)(H,223,281)(H,224,282)(H,225,265)(H,226,277)(H,227,278)(H,228,270)(H,229,262)(H,230,272)(H,231,276)(H,232,280)(H,233,279)(H,234,269)(H,235,288)(H,236,283)(H,237,289)(H,238,258)(H,239,273)(H,240,284)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t103-,104-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246336
PNG
(CHEMBL4106305)
Show SMILES CC[C@H](C)[C@H](NC(=O)C[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)CC(N)=O
Show InChI InChI=1/C180H312N56O49/c1-26-99(20)148(233-140(247)78-110(85-237)209-152(261)112(41-30-34-58-184)212-141(248)84-201-151(260)111(40-29-33-57-183)216-169(278)131(80-146(257)258)231-168(277)128(72-108-82-196-88-203-108)228-166(275)125(68-96(14)15)225-165(274)124(67-95(12)13)223-157(266)116(46-50-133(186)240)219-167(276)127(71-107-81-195-87-202-107)227-159(268)119(49-54-144(253)254)221-171(280)132(86-238)232-173(282)147(98(18)19)234-150(259)101(22)185)174(283)222-117(47-51-134(187)241)158(267)230-130(79-145(255)256)160(269)208-106(62-90(2)3)77-139(246)211-113(42-35-59-198-177(189)190)155(264)218-115(44-37-61-200-179(193)194)156(265)217-114(43-36-60-199-178(191)192)153(262)207-105(45-52-142(249)250)76-138(245)215-120(63-91(4)5)161(270)224-123(66-94(10)11)164(273)220-118(48-53-143(251)252)154(263)206-103(38-27-31-55-181)74-136(243)213-121(64-92(6)7)162(271)226-126(69-97(16)17)172(281)236-180(24,25)176(285)210-104(39-28-32-56-182)75-137(244)214-122(65-93(8)9)163(272)229-129(73-109-83-197-89-204-109)170(279)235-149(102(23)239)175(284)205-100(21)70-135(188)242/h81-83,87-106,110-132,147-149,237-239H,26-80,84-86,181-185H2,1-25H3,(H2,186,240)(H2,187,241)(H2,188,242)(H,195,202)(H,196,203)(H,197,204)(H,201,260)(H,205,284)(H,206,263)(H,207,262)(H,208,269)(H,209,261)(H,210,285)(H,211,246)(H,212,248)(H,213,243)(H,214,244)(H,215,245)(H,216,278)(H,217,265)(H,218,264)(H,219,276)(H,220,273)(H,221,280)(H,222,283)(H,223,266)(H,224,270)(H,225,274)(H,226,271)(H,227,268)(H,228,275)(H,229,272)(H,230,267)(H,231,277)(H,232,282)(H,233,247)(H,234,259)(H,235,279)(H,236,281)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H4,189,190,198)(H4,191,192,199)(H4,193,194,200)/t99-,100-,101-,102+,103-,104-,105-,106-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 4.10n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246418
PNG
(CHEMBL4091191)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)148(238-163(271)112(46-51-141(249)250)208-139(247)73-103(83-239)207-177(285)145(94(12)13)235-150(258)105(186)84-240)180(288)219-114(45-50-135(188)243)158(266)223-122(65-91(6)7)166(274)216-118(55-62-290-20)161(269)228-127(71-101-80-198-87-205-101)170(278)231-130(75-137(190)245)173(281)221-120(63-89(2)3)151(259)203-82-140(248)209-107(39-27-30-56-183)152(260)227-126(70-100-79-197-86-204-100)169(277)225-124(67-93(10)11)167(275)229-131(76-138(191)246)174(282)234-133(85-241)176(284)217-117(54-61-289-19)160(268)214-115(47-52-142(251)252)156(264)212-111(43-34-60-201-182(195)196)162(270)236-146(95(14)15)178(286)218-116(48-53-143(253)254)159(267)226-125(69-99-78-202-106-38-26-25-37-104(99)106)168(276)224-123(66-92(8)9)164(272)213-110(42-33-59-200-181(193)194)154(262)210-108(40-28-31-57-184)153(261)211-109(41-29-32-58-185)155(263)222-121(64-90(4)5)165(273)215-113(44-49-134(187)242)157(265)232-132(77-144(255)256)175(283)237-147(96(16)17)179(287)233-128(72-102-81-199-88-206-102)171(279)230-129(74-136(189)244)172(280)220-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,103,105,107-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,285)(H,208,247)(H,209,248)(H,210,262)(H,211,261)(H,212,264)(H,213,272)(H,214,268)(H,215,273)(H,216,274)(H,217,284)(H,218,286)(H,219,288)(H,220,280)(H,221,281)(H,222,263)(H,223,266)(H,224,276)(H,225,277)(H,226,267)(H,227,260)(H,228,269)(H,229,275)(H,230,279)(H,231,278)(H,232,265)(H,233,287)(H,234,282)(H,235,258)(H,236,270)(H,237,283)(H,238,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,103+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEBI
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269978
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246274
PNG
(CHEMBL4095903)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H292N56O50S/c1-20-96(18)147(238-162(270)116(50-55-142(252)253)215-176(284)133(84-241)234-179(287)144(93(12)13)235-150(258)104(186)82-239)180(288)218-113(47-52-135(188)243)158(266)223-120(64-89(4)5)163(271)208-106-43-32-38-103(106)149(257)220-125(70-99-78-197-85-204-99)168(276)230-129(74-137(190)245)172(280)221-119(63-88(2)3)151(259)203-81-139(247)207-107(40-26-29-57-183)152(260)227-126(71-100-79-198-86-205-100)169(277)225-123(67-92(10)11)166(274)228-130(75-138(191)246)173(281)233-132(83-240)175(283)216-117(56-62-289-19)160(268)213-114(48-53-140(248)249)156(264)211-111(45-34-61-201-182(195)196)161(269)236-145(94(14)15)177(285)217-115(49-54-141(250)251)159(267)226-124(69-98-77-202-105-39-25-24-37-102(98)105)167(275)224-122(66-91(8)9)164(272)212-110(44-33-60-200-181(193)194)154(262)209-108(41-27-30-58-184)153(261)210-109(42-28-31-59-185)155(263)222-121(65-90(6)7)165(273)214-112(46-51-134(187)242)157(265)231-131(76-143(254)255)174(282)237-146(95(16)17)178(286)232-127(72-101-80-199-87-206-101)170(278)229-128(73-136(189)244)171(279)219-118(148(192)256)68-97-35-22-21-23-36-97/h21-25,35-37,39,77-80,85-96,103-104,106-133,144-147,202,239-241H,20,26-34,38,40-76,81-84,183-186H2,1-19H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,256)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,247)(H,208,271)(H,209,262)(H,210,261)(H,211,264)(H,212,272)(H,213,268)(H,214,273)(H,215,284)(H,216,283)(H,217,285)(H,218,288)(H,219,279)(H,220,257)(H,221,280)(H,222,263)(H,223,266)(H,224,275)(H,225,277)(H,226,267)(H,227,260)(H,228,274)(H,229,278)(H,230,276)(H,231,265)(H,232,286)(H,233,281)(H,234,287)(H,235,258)(H,236,269)(H,237,282)(H,238,270)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,193,194,200)(H4,195,196,201)/t96-,103-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,144-,145-,146-,147-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.70n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246316
PNG
(CHEMBL4101396)
Show SMILES CC[C@H](C)[C@H](NC(=O)C[C@@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)148(235-139(247)73-100(44-51-141(249)250)207-175(283)132(84-240)234-179(287)145(94(12)13)236-150(258)105(186)83-239)180(288)218-113(46-50-135(188)243)158(266)222-121(65-91(6)7)165(273)215-117(55-62-290-20)161(269)227-126(71-102-80-198-87-205-102)169(277)230-129(75-137(190)245)172(280)220-119(63-89(2)3)151(259)203-82-140(248)208-107(39-27-30-56-183)152(260)226-125(70-101-79-197-86-204-101)168(276)224-123(67-93(10)11)166(274)228-130(76-138(191)246)173(281)233-133(85-241)176(284)216-116(54-61-289-19)160(268)213-114(47-52-142(251)252)156(264)211-111(43-34-60-201-182(195)196)162(270)237-146(95(14)15)177(285)217-115(48-53-143(253)254)159(267)225-124(69-99-78-202-106-38-26-25-37-104(99)106)167(275)223-122(66-92(8)9)163(271)212-110(42-33-59-200-181(193)194)154(262)209-108(40-28-31-57-184)153(261)210-109(41-29-32-58-185)155(263)221-120(64-90(4)5)164(272)214-112(45-49-134(187)242)157(265)231-131(77-144(255)256)174(282)238-147(96(16)17)178(286)232-127(72-103-81-199-88-206-103)170(278)229-128(74-136(189)244)171(279)219-118(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,100,105,107-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,283)(H,208,248)(H,209,262)(H,210,261)(H,211,264)(H,212,271)(H,213,268)(H,214,272)(H,215,273)(H,216,284)(H,217,285)(H,218,288)(H,219,279)(H,220,280)(H,221,263)(H,222,266)(H,223,275)(H,224,276)(H,225,267)(H,226,260)(H,227,269)(H,228,274)(H,229,278)(H,230,277)(H,231,265)(H,232,286)(H,233,281)(H,234,287)(H,235,247)(H,236,258)(H,237,270)(H,238,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,100+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 9.80n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246292
PNG
(CHEMBL4078125)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C184H296N56O49S2/c1-21-98(18)149(240-165(272)118(51-56-144(253)254)211-151(258)105-39-33-44-108(105)210-179(286)146(95(12)13)237-152(259)106(188)85-241)182(289)221-115(48-53-137(190)244)160(267)225-124(68-92(6)7)168(275)218-120(58-65-291-20)163(270)230-129(74-102-82-200-88-207-102)172(279)233-132(77-139(192)246)175(282)223-122(66-90(2)3)153(260)205-84-141(248)209-109(41-27-30-59-185)154(261)229-128(73-101-81-199-87-206-101)171(278)227-126(70-94(10)11)169(276)231-133(78-140(193)247)176(283)236-135(86-242)178(285)219-119(57-64-290-19)162(269)216-116(49-54-142(249)250)158(265)214-113(46-35-63-203-184(197)198)164(271)238-147(96(14)15)180(287)220-117(50-55-143(251)252)161(268)228-127(72-100-80-204-107-40-26-25-38-104(100)107)170(277)226-125(69-93(8)9)166(273)215-112(45-34-62-202-183(195)196)156(263)212-110(42-28-31-60-186)155(262)213-111(43-29-32-61-187)157(264)224-123(67-91(4)5)167(274)217-114(47-52-136(189)243)159(266)234-134(79-145(255)256)177(284)239-148(97(16)17)181(288)235-130(75-103-83-201-89-208-103)173(280)232-131(76-138(191)245)174(281)222-121(150(194)257)71-99-36-23-22-24-37-99/h22-26,36-38,40,80-83,87-98,105-106,108-135,146-149,204,241-242H,21,27-35,39,41-79,84-86,185-188H2,1-20H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,260)(H,209,248)(H,210,286)(H,211,258)(H,212,263)(H,213,262)(H,214,265)(H,215,273)(H,216,269)(H,217,274)(H,218,275)(H,219,285)(H,220,287)(H,221,289)(H,222,281)(H,223,282)(H,224,264)(H,225,267)(H,226,277)(H,227,278)(H,228,268)(H,229,261)(H,230,270)(H,231,276)(H,232,280)(H,233,279)(H,234,266)(H,235,288)(H,236,283)(H,237,259)(H,238,271)(H,239,284)(H,240,272)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t98-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,146-,147-,148-,149-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 12n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269974
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246417
PNG
(CHEMBL4106295)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C182H294N56O50S2/c1-21-97(18)148(238-162(270)115(48-53-143(253)254)216-176(284)133(85-241)234-179(287)145(94(12)13)235-150(258)105(186)83-239)180(288)207-100(44-49-134(187)242)73-139(247)209-120(64-90(4)5)163(271)217-117(55-62-290-20)160(268)227-126(71-102-80-198-87-205-102)169(277)230-129(75-137(190)245)172(280)221-119(63-89(2)3)151(259)203-82-140(248)208-107(39-27-30-56-183)152(260)226-125(70-101-79-197-86-204-101)168(276)224-123(67-93(10)11)166(274)228-130(76-138(191)246)173(281)233-132(84-240)175(283)218-116(54-61-289-19)159(267)214-113(46-51-141(249)250)156(264)212-111(43-34-60-201-182(195)196)161(269)236-146(95(14)15)177(285)219-114(47-52-142(251)252)158(266)225-124(69-99-78-202-106-38-26-25-37-104(99)106)167(275)223-122(66-92(8)9)164(272)213-110(42-33-59-200-181(193)194)154(262)210-108(40-28-31-57-184)153(261)211-109(41-29-32-58-185)155(263)222-121(65-91(6)7)165(273)215-112(45-50-135(188)243)157(265)231-131(77-144(255)256)174(282)237-147(96(16)17)178(286)232-127(72-103-81-199-88-206-103)170(278)229-128(74-136(189)244)171(279)220-118(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,100,105,107-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,288)(H,208,248)(H,209,247)(H,210,262)(H,211,261)(H,212,264)(H,213,272)(H,214,267)(H,215,273)(H,216,284)(H,217,271)(H,218,283)(H,219,285)(H,220,279)(H,221,280)(H,222,263)(H,223,275)(H,224,276)(H,225,266)(H,226,260)(H,227,268)(H,228,274)(H,229,278)(H,230,277)(H,231,265)(H,232,286)(H,233,281)(H,234,287)(H,235,258)(H,236,269)(H,237,282)(H,238,270)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,100-,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246246
PNG
(CHEMBL4067009)
Show SMILES CSCC[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1/C183H295N55O45S/c1-87(2)65-124(224-175(277)132(73-141(190)244)230-172(274)129(70-95-76-199-85-205-95)227-166(268)123(59-64-284-15)217-153(255)101-35-25-45-111(101)210-162(264)119(51-55-138(187)241)215-151(253)100-34-24-44-110(100)211-164(266)122(54-58-145(249)250)221-178(280)137(84-240)235-181(283)147(92(11)12)236-150(252)98-32-22-39-107(98)186)158(260)204-82-143(246)207-115(41-18-20-60-184)159(261)209-112-46-27-37-103(112)154(256)222-125(66-88(3)4)170(272)228-133(74-142(191)245)176(278)234-136(83-239)177(279)213-113-47-26-36-102(113)152(254)216-121(53-57-144(247)248)165(267)218-118(50-30-63-202-183(195)196)167(269)238-148(93(13)14)180(282)233-135-81-198-79-106(135)157(259)223-128(69-94-75-203-108-40-17-16-31-97(94)108)171(273)226-127(68-90(7)8)168(270)219-117(49-29-62-201-182(193)194)161(263)232-134-80-197-78-105(134)156(258)214-116(42-19-21-61-185)160(262)225-126(67-89(5)6)169(271)220-120(52-56-139(188)242)163(265)212-114-48-28-38-104(114)155(257)237-146(91(9)10)179(281)231-130(71-96-77-200-86-206-96)173(275)229-131(72-140(189)243)174(276)208-109-43-23-33-99(109)149(192)251/h16-17,31,40,75-77,85-93,98-107,109-137,146-148,197-198,203,239-240H,18-30,32-39,41-74,78-84,184-186H2,1-15H3,(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,251)(H,199,205)(H,200,206)(H,204,260)(H,207,246)(H,208,276)(H,209,261)(H,210,264)(H,211,266)(H,212,265)(H,213,279)(H,214,258)(H,215,253)(H,216,254)(H,217,255)(H,218,267)(H,219,270)(H,220,271)(H,221,280)(H,222,256)(H,223,259)(H,224,277)(H,225,262)(H,226,273)(H,227,268)(H,228,272)(H,229,275)(H,230,274)(H,231,281)(H,232,263)(H,233,282)(H,234,278)(H,235,283)(H,236,252)(H,237,257)(H,238,269)(H,247,248)(H,249,250)(H4,193,194,201)(H4,195,196,202)/t98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,146-,147-,148-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 19n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
More data for this
Ligand-Target Pair
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