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Compile Data Set for Download or QSAR

Found 155 hits Enz. Inhib. hit(s) with Target = 'Parathyroid hormone receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246337
PNG
(CHEMBL4084894)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C174H300N56O49/c1-26-93(20)136(228-165(274)126(80-232)224-141(250)101(39-28-32-56-176)200-129(236)78-195-140(249)100(38-27-31-55-175)201-161(270)123(73-133(243)244)223-160(269)121(71-98-76-190-82-197-98)220-158(267)118(68-90(14)15)216-155(264)114(64-86(6)7)213-148(257)107(45-50-127(180)234)207-159(268)120(70-97-75-189-81-196-97)219-151(260)111(49-54-132(241)242)209-164(273)125(79-231)225-167(276)135(92(18)19)227-139(248)94(21)179)168(277)210-108(46-51-128(181)235)149(258)222-124(74-134(245)246)162(271)217-112(62-84(2)3)152(261)205-105(44-37-61-194-173(187)188)143(252)203-103(42-35-59-192-171(183)184)142(251)204-104(43-36-60-193-172(185)186)144(253)206-110(48-53-131(239)240)150(259)214-115(65-87(8)9)154(263)215-113(63-85(4)5)153(262)208-109(47-52-130(237)238)147(256)202-102(40-29-33-57-177)145(254)211-116(66-88(10)11)156(265)218-119(69-91(16)17)166(275)230-174(24,25)170(279)226-106(41-30-34-58-178)146(255)212-117(67-89(12)13)157(266)221-122(72-99-77-191-83-198-99)163(272)229-137(96(23)233)169(278)199-95(22)138(182)247/h75-77,81-96,100-126,135-137,231-233H,26-74,78-80,175-179H2,1-25H3,(H2,180,234)(H2,181,235)(H2,182,247)(H,189,196)(H,190,197)(H,191,198)(H,195,249)(H,199,278)(H,200,236)(H,201,270)(H,202,256)(H,203,252)(H,204,251)(H,205,261)(H,206,253)(H,207,268)(H,208,262)(H,209,273)(H,210,277)(H,211,254)(H,212,255)(H,213,257)(H,214,259)(H,215,263)(H,216,264)(H,217,271)(H,218,265)(H,219,260)(H,220,267)(H,221,266)(H,222,258)(H,223,269)(H,224,250)(H,225,276)(H,226,279)(H,227,248)(H,228,274)(H,229,272)(H,230,275)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H4,183,184,192)(H4,185,186,193)(H4,187,188,194)/t93-,94-,95-,96+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,135-,136-,137-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.0200n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246318
PNG
(CHEMBL4098420)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C182H294N56O50S2/c1-21-97(18)148(238-162(270)115(48-53-143(253)254)214-176(284)133(85-241)234-177(285)145(94(12)13)235-139(247)70-100(186)83-239)180(288)218-112(45-50-135(188)243)157(265)222-121(65-91(6)7)165(273)215-117(55-62-290-20)160(268)227-126(72-102-80-198-87-205-102)169(277)230-129(75-137(190)245)172(280)220-119(63-89(2)3)150(258)203-82-140(248)207-106(39-27-30-56-183)151(259)226-125(71-101-79-197-86-204-101)168(276)224-123(67-93(10)11)166(274)228-130(76-138(191)246)173(281)233-132(84-240)175(283)216-116(54-61-289-19)159(267)212-113(46-51-141(249)250)155(263)210-110(43-34-60-201-182(195)196)161(269)236-146(95(14)15)178(286)217-114(47-52-142(251)252)158(266)225-124(69-99-78-202-105-38-26-25-37-104(99)105)167(275)223-122(66-92(8)9)163(271)211-109(42-33-59-200-181(193)194)153(261)208-107(40-28-31-57-184)152(260)209-108(41-29-32-58-185)154(262)221-120(64-90(4)5)164(272)213-111(44-49-134(187)242)156(264)231-131(77-144(255)256)174(282)237-147(96(16)17)179(287)232-127(73-103-81-199-88-206-103)170(278)229-128(74-136(189)244)171(279)219-118(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,100,106-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,258)(H,207,248)(H,208,261)(H,209,260)(H,210,263)(H,211,271)(H,212,267)(H,213,272)(H,214,284)(H,215,273)(H,216,283)(H,217,286)(H,218,288)(H,219,279)(H,220,280)(H,221,262)(H,222,265)(H,223,275)(H,224,276)(H,225,266)(H,226,259)(H,227,268)(H,228,274)(H,229,278)(H,230,277)(H,231,264)(H,232,287)(H,233,281)(H,234,285)(H,235,247)(H,236,269)(H,237,282)(H,238,270)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,100+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.0600n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269975
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C77H129N23O19/c1-13-15-20-47(91-69(114)54(35-40(3)4)95-67(112)51(28-31-57(80)103)93-71(116)60(42(7)14-2)98-68(113)52(29-32-58(104)105)97-74(119)77(11,12)100-72(117)59(41(5)6)99-73(118)76(9,10)84)65(110)96-55(37-45-38-85-39-87-45)70(115)92-50(27-30-56(79)102)66(111)90-48(22-17-19-34-86-75(82)83)63(108)88-43(8)62(107)89-49(21-16-18-33-78)64(109)94-53(61(81)106)36-44-23-25-46(101)26-24-44/h23-26,38-43,47-55,59-60,101H,13-22,27-37,78,84H2,1-12H3,(H2,79,102)(H2,80,103)(H2,81,106)(H,85,87)(H,88,108)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,116)(H,94,109)(H,95,112)(H,96,110)(H,97,119)(H,98,113)(H,99,118)(H,100,117)(H,104,105)(H4,82,83,86)/t42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0600n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246319
PNG
(CHEMBL4080397)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C181H292N56O50S2/c1-21-96(18)146(237-161(269)114(48-53-141(251)252)213-175(283)132(84-240)233-178(286)143(93(12)13)234-148(256)103(185)82-238)179(287)217-111(45-50-134(187)242)156(264)221-120(65-90(6)7)164(272)214-116(55-62-289-20)159(267)226-125(71-100-79-197-86-204-100)168(276)229-128(74-136(189)244)171(279)219-118(63-88(2)3)149(257)202-81-138(246)206-105(39-27-30-56-182)150(258)225-124(70-99-78-196-85-203-99)167(275)223-122(67-92(10)11)165(273)227-129(75-137(190)245)172(280)232-131(83-239)174(282)215-115(54-61-288-19)158(266)211-112(46-51-139(247)248)154(262)209-109(43-34-60-200-181(194)195)160(268)235-144(94(14)15)176(284)216-113(47-52-140(249)250)157(265)224-123(69-98-77-201-104-38-26-25-37-102(98)104)166(274)222-121(66-91(8)9)162(270)210-108(42-33-59-199-180(192)193)152(260)207-106(40-28-31-57-183)151(259)208-107(41-29-32-58-184)153(261)220-119(64-89(4)5)163(271)212-110(44-49-133(186)241)155(263)230-130(76-142(253)254)173(281)236-145(95(16)17)177(285)231-126(72-101-80-198-87-205-101)169(277)228-127(73-135(188)243)170(278)218-117(147(191)255)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,201,238-240H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,255)(H,196,203)(H,197,204)(H,198,205)(H,202,257)(H,206,246)(H,207,260)(H,208,259)(H,209,262)(H,210,270)(H,211,266)(H,212,271)(H,213,283)(H,214,272)(H,215,282)(H,216,284)(H,217,287)(H,218,278)(H,219,279)(H,220,261)(H,221,264)(H,222,274)(H,223,275)(H,224,265)(H,225,258)(H,226,267)(H,227,273)(H,228,277)(H,229,276)(H,230,263)(H,231,285)(H,232,280)(H,233,286)(H,234,256)(H,235,268)(H,236,281)(H,237,269)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,192,193,199)(H4,194,195,200)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.0700n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246362
PNG
(CHEMBL4060034)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C180H288N58O47/c1-23-94(16)141(174(282)208-99(21)147(255)210-116(51-55-137(247)248)156(264)235-143(96(18)25-3)176(284)231-128(72-107-79-197-87-206-107)170(278)238-144(100(22)241)177(285)207-98(20)145(186)253)236-169(277)121(65-92(12)13)222-164(272)125(69-104-76-194-84-203-104)228-165(273)126(70-105-77-195-85-204-105)226-160(268)120(64-91(10)11)220-161(269)123(67-102-41-30-27-31-42-102)224-162(270)122(66-101-39-28-26-29-40-101)223-152(260)112(47-38-60-200-180(191)192)213-150(258)110(45-36-58-198-178(187)188)212-151(259)111(46-37-59-199-179(189)190)214-157(265)117(61-88(4)5)221-168(276)130(74-139(251)252)229-154(262)114(49-53-134(185)243)217-175(283)142(95(17)24-2)237-172(280)132(82-240)232-149(257)109(44-33-35-57-182)209-135(244)80-201-148(256)108(43-32-34-56-181)211-167(275)129(73-138(249)250)230-166(274)127(71-106-78-196-86-205-106)227-159(267)119(63-90(8)9)219-158(266)118(62-89(6)7)218-153(261)113(48-52-133(184)242)215-163(271)124(68-103-75-193-83-202-103)225-155(263)115(50-54-136(245)246)216-171(279)131(81-239)233-173(281)140(93(14)15)234-146(254)97(19)183/h26-31,39-42,75-79,83-100,108-132,140-144,239-241H,23-25,32-38,43-74,80-82,181-183H2,1-22H3,(H2,184,242)(H2,185,243)(H2,186,253)(H,193,202)(H,194,203)(H,195,204)(H,196,205)(H,197,206)(H,201,256)(H,207,285)(H,208,282)(H,209,244)(H,210,255)(H,211,275)(H,212,259)(H,213,258)(H,214,265)(H,215,271)(H,216,279)(H,217,283)(H,218,261)(H,219,266)(H,220,269)(H,221,276)(H,222,272)(H,223,260)(H,224,270)(H,225,263)(H,226,268)(H,227,267)(H,228,273)(H,229,262)(H,230,274)(H,231,284)(H,232,257)(H,233,281)(H,234,254)(H,235,264)(H,236,277)(H,237,280)(H,238,278)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H4,187,188,198)(H4,189,190,199)(H4,191,192,200)/t94-,95-,96-,97-,98-,99-,100+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,140-,141-,142-,143-,144-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0800n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246387
PNG
(CHEMBL4090619)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C181H290N56O50S2/c1-19-95(16)146(237-162(270)115(49-54-141(251)252)215-175(283)132(84-240)233-178(286)143(92(10)11)234-149(257)103(185)82-238)179(287)218-112(46-51-134(187)242)155(263)207-105-42-31-37-102(105)148(256)208-116(55-62-288-17)160(268)226-125(71-99-79-197-86-204-99)168(276)229-128(74-136(189)244)171(279)220-119(64-88(2)3)150(258)202-81-138(246)206-106(39-25-28-57-182)151(259)225-124(70-98-78-196-85-203-98)167(275)223-122(67-91(8)9)165(273)227-129(75-137(190)245)172(280)232-131(83-239)174(282)216-117(56-63-289-18)159(267)213-113(47-52-139(247)248)156(264)211-110(44-33-61-200-181(194)195)161(269)235-144(93(12)13)176(284)217-114(48-53-140(249)250)158(266)224-123(69-97-77-201-104-38-24-23-36-101(97)104)166(274)222-121(66-90(6)7)163(271)212-109(43-32-60-199-180(192)193)153(261)209-107(40-26-29-58-183)152(260)210-108(41-27-30-59-184)154(262)221-120(65-89(4)5)164(272)214-111(45-50-133(186)241)157(265)230-130(76-142(253)254)173(281)236-145(94(14)15)177(285)231-126(72-100-80-198-87-205-100)169(277)228-127(73-135(188)243)170(278)219-118(147(191)255)68-96-34-21-20-22-35-96/h20-24,34-36,38,77-80,85-95,102-103,105-132,143-146,201,238-240H,19,25-33,37,39-76,81-84,182-185H2,1-18H3,(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,255)(H,196,203)(H,197,204)(H,198,205)(H,202,258)(H,206,246)(H,207,263)(H,208,256)(H,209,261)(H,210,260)(H,211,264)(H,212,271)(H,213,267)(H,214,272)(H,215,283)(H,216,282)(H,217,284)(H,218,287)(H,219,278)(H,220,279)(H,221,262)(H,222,274)(H,223,275)(H,224,266)(H,225,259)(H,226,268)(H,227,273)(H,228,277)(H,229,276)(H,230,265)(H,231,285)(H,232,280)(H,233,286)(H,234,257)(H,235,269)(H,236,281)(H,237,270)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,192,193,199)(H4,194,195,200)/t95-,102-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.120n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246250
PNG
(CHEMBL4106296)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C192H307N55O50S2/c1-21-105(18)163(247-174(281)129(52-57-158(267)268)230-186(293)143(94-250)243-189(296)162(104(16)17)245-164(271)119(196)92-248)190(297)232-128(50-54-145(198)252)171(278)235-134(70-100(8)9)179(286)231-130(59-66-299-20)172(279)237-137(75-115-89-207-95-214-115)181(288)240-140(85-148(201)255)183(290)233-131(67-97(2)3)165(272)213-91-155(262)224-122(44-30-33-61-194)166(273)220-113(73-107-87-211-120-42-27-25-40-117(107)120)81-153(260)225-132(68-98(4)5)176(283)239-141(86-149(202)256)184(291)242-142(93-249)185(292)217-111(58-65-298-19)80-151(258)223-126(51-56-157(265)266)170(277)227-125(47-36-64-210-192(205)206)173(280)246-161(103(14)15)187(294)218-110(48-55-156(263)264)79-152(259)226-136(74-108-88-212-121-43-28-26-41-118(108)121)180(287)236-135(71-101(10)11)177(284)228-124(46-35-63-209-191(203)204)167(274)216-109(39-29-32-60-193)78-150(257)222-123(45-31-34-62-195)169(276)234-133(69-99(6)7)178(285)229-127(49-53-144(197)251)168(275)221-114(83-159(269)270)82-154(261)244-160(102(12)13)188(295)241-138(76-116-90-208-96-215-116)182(289)238-139(84-147(200)254)175(282)219-112(77-146(199)253)72-106-37-23-22-24-38-106/h22-28,37-38,40-43,87-90,95-105,109-114,119,122-143,160-163,211-212,248-250H,21,29-36,39,44-86,91-94,193-196H2,1-20H3,(H2,197,251)(H2,198,252)(H2,199,253)(H2,200,254)(H2,201,255)(H2,202,256)(H,207,214)(H,208,215)(H,213,272)(H,216,274)(H,217,292)(H,218,294)(H,219,282)(H,220,273)(H,221,275)(H,222,257)(H,223,258)(H,224,262)(H,225,260)(H,226,259)(H,227,277)(H,228,284)(H,229,285)(H,230,293)(H,231,286)(H,232,297)(H,233,290)(H,234,276)(H,235,278)(H,236,287)(H,237,279)(H,238,289)(H,239,283)(H,240,288)(H,241,295)(H,242,291)(H,243,296)(H,244,261)(H,245,271)(H,246,280)(H,247,281)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H4,203,204,209)(H4,205,206,210)/t105-,109-,110-,111-,112-,113-,114+,119-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.130n/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Agonist activity at PTH1 receptor (unknown origin) assessed as induction of cAMP


J Med Chem 61: 9004-9029 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00378
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246270
PNG
(CHEMBL4088173)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C184H294N56O49S2/c1-19-97(16)149(240-165(272)118(52-57-144(253)254)218-178(285)135(86-242)236-181(288)146(94(10)11)237-151(258)104-38-31-40-106(104)188)182(289)221-115(49-54-137(190)244)158(265)210-108-45-32-39-105(108)152(259)211-119(58-65-290-17)163(270)229-128(74-101-82-200-88-207-101)171(278)232-131(77-139(192)246)174(281)223-122(67-90(2)3)153(260)205-84-141(248)209-109(42-25-28-60-185)154(261)228-127(73-100-81-199-87-206-100)170(277)226-125(70-93(8)9)168(275)230-132(78-140(193)247)175(282)235-134(85-241)177(284)219-120(59-66-291-18)162(269)216-116(50-55-142(249)250)159(266)214-113(47-34-64-203-184(197)198)164(271)238-147(95(12)13)179(286)220-117(51-56-143(251)252)161(268)227-126(72-99-80-204-107-41-24-23-37-103(99)107)169(276)225-124(69-92(6)7)166(273)215-112(46-33-63-202-183(195)196)156(263)212-110(43-26-29-61-186)155(262)213-111(44-27-30-62-187)157(264)224-123(68-91(4)5)167(274)217-114(48-53-136(189)243)160(267)233-133(79-145(255)256)176(283)239-148(96(14)15)180(287)234-129(75-102-83-201-89-208-102)172(279)231-130(76-138(191)245)173(280)222-121(150(194)257)71-98-35-21-20-22-36-98/h20-24,35-37,41,80-83,87-97,104-106,108-135,146-149,204,241-242H,19,25-34,38-40,42-79,84-86,185-188H2,1-18H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,260)(H,209,248)(H,210,265)(H,211,259)(H,212,263)(H,213,262)(H,214,266)(H,215,273)(H,216,269)(H,217,274)(H,218,285)(H,219,284)(H,220,286)(H,221,289)(H,222,280)(H,223,281)(H,224,264)(H,225,276)(H,226,277)(H,227,268)(H,228,261)(H,229,270)(H,230,275)(H,231,279)(H,232,278)(H,233,267)(H,234,287)(H,235,282)(H,236,288)(H,237,258)(H,238,271)(H,239,283)(H,240,272)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t97-,104-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,146-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.140n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246293
PNG
(CHEMBL4061182)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C184H296N56O49S2/c1-21-98(18)149(240-164(271)117(51-56-144(253)254)216-178(285)135(86-242)236-181(288)146(95(12)13)237-151(258)105-39-33-40-106(105)188)182(289)220-114(48-53-137(190)244)159(266)224-123(68-92(6)7)167(274)217-119(58-65-291-20)162(269)229-128(74-102-82-200-88-207-102)171(278)232-131(77-139(192)246)174(281)222-121(66-90(2)3)152(259)205-84-141(248)209-108(42-27-30-59-185)153(260)228-127(73-101-81-199-87-206-101)170(277)226-125(70-94(10)11)168(275)230-132(78-140(193)247)175(282)235-134(85-241)177(284)218-118(57-64-290-19)161(268)214-115(49-54-142(249)250)157(264)212-112(46-35-63-203-184(197)198)163(270)238-147(96(14)15)179(286)219-116(50-55-143(251)252)160(267)227-126(72-100-80-204-107-41-26-25-38-104(100)107)169(276)225-124(69-93(8)9)165(272)213-111(45-34-62-202-183(195)196)155(262)210-109(43-28-31-60-186)154(261)211-110(44-29-32-61-187)156(263)223-122(67-91(4)5)166(273)215-113(47-52-136(189)243)158(265)233-133(79-145(255)256)176(283)239-148(97(16)17)180(287)234-129(75-103-83-201-89-208-103)172(279)231-130(76-138(191)245)173(280)221-120(150(194)257)71-99-36-23-22-24-37-99/h22-26,36-38,41,80-83,87-98,105-106,108-135,146-149,204,241-242H,21,27-35,39-40,42-79,84-86,185-188H2,1-20H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,259)(H,209,248)(H,210,262)(H,211,261)(H,212,264)(H,213,272)(H,214,268)(H,215,273)(H,216,285)(H,217,274)(H,218,284)(H,219,286)(H,220,289)(H,221,280)(H,222,281)(H,223,263)(H,224,266)(H,225,276)(H,226,277)(H,227,267)(H,228,260)(H,229,269)(H,230,275)(H,231,279)(H,232,278)(H,233,265)(H,234,287)(H,235,282)(H,236,288)(H,237,258)(H,238,270)(H,239,283)(H,240,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t98-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,146-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246291
PNG
(CHEMBL4098344)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C181H290N56O50S2/c1-88(2)63-119(220-172(280)129(74-137(189)244)230-169(277)126(71-99-79-197-86-204-99)227-161(269)117(55-62-289-18)216-165(273)121(65-90(5)6)222-157(265)111(44-49-134(186)241)208-148(256)102-36-30-41-105(102)207-155(263)113(46-51-140(247)248)215-176(284)133(84-240)234-179(287)144(93(11)12)235-149(257)103(185)82-238)150(258)202-81-139(246)206-106(38-24-27-56-182)151(259)226-125(70-98-78-196-85-203-98)168(276)224-123(67-92(9)10)166(274)228-130(75-138(190)245)173(281)233-132(83-239)175(283)217-116(54-61-288-17)160(268)213-114(47-52-141(249)250)156(264)211-110(43-32-60-200-181(194)195)162(270)236-145(94(13)14)177(285)218-115(48-53-142(251)252)159(267)225-124(69-97-77-201-104-37-23-22-35-101(97)104)167(275)223-122(66-91(7)8)163(271)212-109(42-31-59-199-180(192)193)153(261)209-107(39-25-28-57-183)152(260)210-108(40-26-29-58-184)154(262)221-120(64-89(3)4)164(272)214-112(45-50-135(187)242)158(266)231-131(76-143(253)254)174(282)237-146(95(15)16)178(286)232-127(72-100-80-198-87-205-100)170(278)229-128(73-136(188)243)171(279)219-118(147(191)255)68-96-33-20-19-21-34-96/h19-23,33-35,37,77-80,85-95,102-103,105-133,144-146,201,238-240H,24-32,36,38-76,81-84,182-185H2,1-18H3,(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,255)(H,196,203)(H,197,204)(H,198,205)(H,202,258)(H,206,246)(H,207,263)(H,208,256)(H,209,261)(H,210,260)(H,211,264)(H,212,271)(H,213,268)(H,214,272)(H,215,284)(H,216,273)(H,217,283)(H,218,285)(H,219,279)(H,220,280)(H,221,262)(H,222,265)(H,223,275)(H,224,276)(H,225,267)(H,226,259)(H,227,269)(H,228,274)(H,229,278)(H,230,277)(H,231,266)(H,232,286)(H,233,281)(H,234,287)(H,235,257)(H,236,270)(H,237,282)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,192,193,199)(H4,194,195,200)/t102-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246250
PNG
(CHEMBL4106296)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C192H307N55O50S2/c1-21-105(18)163(247-174(281)129(52-57-158(267)268)230-186(293)143(94-250)243-189(296)162(104(16)17)245-164(271)119(196)92-248)190(297)232-128(50-54-145(198)252)171(278)235-134(70-100(8)9)179(286)231-130(59-66-299-20)172(279)237-137(75-115-89-207-95-214-115)181(288)240-140(85-148(201)255)183(290)233-131(67-97(2)3)165(272)213-91-155(262)224-122(44-30-33-61-194)166(273)220-113(73-107-87-211-120-42-27-25-40-117(107)120)81-153(260)225-132(68-98(4)5)176(283)239-141(86-149(202)256)184(291)242-142(93-249)185(292)217-111(58-65-298-19)80-151(258)223-126(51-56-157(265)266)170(277)227-125(47-36-64-210-192(205)206)173(280)246-161(103(14)15)187(294)218-110(48-55-156(263)264)79-152(259)226-136(74-108-88-212-121-43-28-26-41-118(108)121)180(287)236-135(71-101(10)11)177(284)228-124(46-35-63-209-191(203)204)167(274)216-109(39-29-32-60-193)78-150(257)222-123(45-31-34-62-195)169(276)234-133(69-99(6)7)178(285)229-127(49-53-144(197)251)168(275)221-114(83-159(269)270)82-154(261)244-160(102(12)13)188(295)241-138(76-116-90-208-96-215-116)182(289)238-139(84-147(200)254)175(282)219-112(77-146(199)253)72-106-37-23-22-24-38-106/h22-28,37-38,40-43,87-90,95-105,109-114,119,122-143,160-163,211-212,248-250H,21,29-36,39,44-86,91-94,193-196H2,1-20H3,(H2,197,251)(H2,198,252)(H2,199,253)(H2,200,254)(H2,201,255)(H2,202,256)(H,207,214)(H,208,215)(H,213,272)(H,216,274)(H,217,292)(H,218,294)(H,219,282)(H,220,273)(H,221,275)(H,222,257)(H,223,258)(H,224,262)(H,225,260)(H,226,259)(H,227,277)(H,228,284)(H,229,285)(H,230,293)(H,231,286)(H,232,297)(H,233,290)(H,234,276)(H,235,278)(H,236,287)(H,237,279)(H,238,289)(H,239,283)(H,240,288)(H,241,295)(H,242,291)(H,243,296)(H,244,261)(H,245,271)(H,246,280)(H,247,281)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H4,203,204,209)(H4,205,206,210)/t105-,109-,110-,111-,112-,113-,114+,119-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246419
PNG
(CHEMBL4074628)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C179H300N56O46/c1-23-93(18)141(233-147(253)101-37-30-43-107(101)205-151(257)110(40-25-27-57-181)204-135(240)80-200-150(256)109(39-24-26-56-180)209-168(274)129(72-139(247)248)227-166(272)126(69-97-74-195-83-202-97)224-164(270)123(66-90(12)13)221-163(269)122(65-89(10)11)219-155(261)114(48-52-133(183)238)212-165(271)125(68-96-73-194-82-201-96)223-157(263)116(50-54-136(241)242)214-170(276)132(81-236)230-172(278)140(92(16)17)232-144(250)94(19)182)173(279)215-115(49-53-134(184)239)156(262)226-128(71-138(245)246)167(273)206-106-42-29-36-100(106)145(251)208-111(45-32-58-197-176(186)187)152(258)210-112(46-33-59-198-177(188)189)153(259)211-113(47-34-60-199-178(190)191)154(260)228-130-78-192-76-103(130)148(254)217-119(62-86(4)5)160(266)220-121(64-88(8)9)159(265)213-117(51-55-137(243)244)158(264)229-131-79-193-77-104(131)149(255)218-120(63-87(6)7)161(267)222-124(67-91(14)15)171(277)235-179(21,22)175(281)231-108-44-31-38-102(108)146(252)216-118(61-85(2)3)162(268)225-127(70-98-75-196-84-203-98)169(275)234-142(95(20)237)174(280)207-105-41-28-35-99(105)143(185)249/h73-75,82-95,99-132,140-142,192-193,236-237H,23-72,76-81,180-182H2,1-22H3,(H2,183,238)(H2,184,239)(H2,185,249)(H,194,201)(H,195,202)(H,196,203)(H,200,256)(H,204,240)(H,205,257)(H,206,273)(H,207,280)(H,208,251)(H,209,274)(H,210,258)(H,211,259)(H,212,271)(H,213,265)(H,214,276)(H,215,279)(H,216,252)(H,217,254)(H,218,255)(H,219,261)(H,220,266)(H,221,269)(H,222,267)(H,223,263)(H,224,270)(H,225,268)(H,226,262)(H,227,272)(H,228,260)(H,229,264)(H,230,278)(H,231,281)(H,232,250)(H,233,253)(H,234,275)(H,235,277)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H4,186,187,197)(H4,188,189,198)(H4,190,191,199)/t93-,94-,95+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,140-,141-,142-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.180n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50331021
PNG
((S)-5-((2S,3S)-1-((3S,6S,9S,12S,15S)-6-((1H-imidaz...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](COC(=O)CCCCC(=O)OC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC
Show InChI InChI=1S/C61H103N17O17/c1-12-14-19-37-49(84)72-40(27-35-28-66-31-68-35)52(87)73-41(53(88)69-36(48(62)83)20-17-18-25-67-59(63)64)29-94-44(81)21-15-16-22-45(82)95-30-42(54(89)71-39(26-32(3)4)51(86)70-37)74-55(90)47(34(7)13-2)76-50(85)38(23-24-43(79)80)75-58(93)61(10,11)78-56(91)46(33(5)6)77-57(92)60(8,9)65/h28,31-34,36-42,46-47H,12-27,29-30,65H2,1-11H3,(H2,62,83)(H,66,68)(H,69,88)(H,70,86)(H,71,89)(H,72,84)(H,73,87)(H,74,90)(H,75,93)(H,76,85)(H,77,92)(H,78,91)(H,79,80)(H4,63,64,67)/t34-,36-,37-,38-,39-,40-,41-,42-,46-,47-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)


Article DOI: 10.1021/jm1008264
BindingDB Entry DOI: 10.7270/Q2GM87KQ
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246249
PNG
(CHEMBL4063722)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C180H295N55O46S/c1-20-93(18)145(235-162(265)117(50-54-141(247)248)214-174(277)133(82-238)231-177(280)143(91(14)15)233-152(255)104(183)80-236)178(281)216-115(48-52-135(185)240)159(262)221-122(64-88(8)9)165(268)215-118(55-60-282-19)160(263)223-125(67-95-73-196-83-202-95)168(271)226-128(70-137(187)242)171(274)219-119(61-85(2)3)153(256)201-79-139(244)204-110(39-23-25-56-181)154(257)206-107-42-29-36-100(107)148(251)217-120(62-86(4)5)166(269)224-129(71-138(188)243)172(275)230-132(81-237)173(276)208-108-43-28-35-99(108)147(250)210-116(49-53-140(245)246)158(261)211-113(46-32-59-199-180(192)193)161(264)234-144(92(16)17)176(279)229-131-78-195-76-103(131)151(254)218-124(66-94-72-200-105-38-22-21-33-97(94)105)167(270)222-123(65-89(10)11)163(266)212-112(45-31-58-198-179(190)191)156(259)228-130-77-194-75-102(130)150(253)209-111(40-24-26-57-182)155(258)220-121(63-87(6)7)164(267)213-114(47-51-134(184)239)157(260)207-109-44-30-37-101(109)149(252)232-142(90(12)13)175(278)227-126(68-96-74-197-84-203-96)169(272)225-127(69-136(186)241)170(273)205-106-41-27-34-98(106)146(189)249/h21-22,33,38,72-74,83-93,98-104,106-133,142-145,194-195,200,236-238H,20,23-32,34-37,39-71,75-82,181-183H2,1-19H3,(H2,184,239)(H2,185,240)(H2,186,241)(H2,187,242)(H2,188,243)(H2,189,249)(H,196,202)(H,197,203)(H,201,256)(H,204,244)(H,205,273)(H,206,257)(H,207,260)(H,208,276)(H,209,253)(H,210,250)(H,211,261)(H,212,266)(H,213,267)(H,214,277)(H,215,268)(H,216,281)(H,217,251)(H,218,254)(H,219,274)(H,220,258)(H,221,262)(H,222,270)(H,223,263)(H,224,269)(H,225,272)(H,226,271)(H,227,278)(H,228,259)(H,229,279)(H,230,275)(H,231,280)(H,232,252)(H,233,255)(H,234,264)(H,235,265)(H,245,246)(H,247,248)(H4,190,191,198)(H4,192,193,199)/t93-,98-,99-,100-,101-,102-,103-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,142-,143-,144-,145-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 0.260n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246388
PNG
(CHEMBL4097998)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C182H292N56O50S2/c1-19-96(16)147(238-163(271)116(49-54-143(252)253)215-176(284)133(84-240)234-149(257)103-37-31-42-106(103)208-150(258)104(186)83-239)180(288)219-113(46-51-136(188)243)158(266)223-122(66-91(6)7)166(274)216-118(56-63-290-18)161(269)228-127(72-100-80-198-87-205-100)170(278)231-130(75-138(190)245)173(281)221-120(64-89(2)3)151(259)203-82-140(247)207-107(39-25-28-57-183)152(260)227-126(71-99-79-197-86-204-99)169(277)225-124(68-93(10)11)167(275)229-131(76-139(191)246)174(282)235-134(85-241)177(285)217-117(55-62-289-17)160(268)213-114(47-52-141(248)249)156(264)211-111(44-33-61-201-182(195)196)162(270)236-145(94(12)13)178(286)218-115(48-53-142(250)251)159(267)226-125(70-98-78-202-105-38-24-23-36-102(98)105)168(276)224-123(67-92(8)9)164(272)212-110(43-32-60-200-181(193)194)154(262)209-108(40-26-29-58-184)153(261)210-109(41-27-30-59-185)155(263)222-121(65-90(4)5)165(273)214-112(45-50-135(187)242)157(265)232-132(77-144(254)255)175(283)237-146(95(14)15)179(287)233-128(73-101-81-199-88-206-101)171(279)230-129(74-137(189)244)172(280)220-119(148(192)256)69-97-34-21-20-22-35-97/h20-24,34-36,38,78-81,86-96,103-104,106-134,145-147,202,239-241H,19,25-33,37,39-77,82-85,183-186H2,1-18H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,256)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,247)(H,208,258)(H,209,262)(H,210,261)(H,211,264)(H,212,272)(H,213,268)(H,214,273)(H,215,284)(H,216,274)(H,217,285)(H,218,286)(H,219,288)(H,220,280)(H,221,281)(H,222,263)(H,223,266)(H,224,276)(H,225,277)(H,226,267)(H,227,260)(H,228,269)(H,229,275)(H,230,279)(H,231,278)(H,232,265)(H,233,287)(H,234,257)(H,235,282)(H,236,270)(H,237,283)(H,238,271)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,193,194,200)(H4,195,196,201)/t96-,103-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,145-,146-,147-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.270n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246317
PNG
(CHEMBL4063322)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)C[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C182H294N56O50S2/c1-21-97(18)148(238-163(271)115(48-53-144(253)254)215-176(284)133(84-240)208-140(247)76-118(94(12)13)220-150(258)104(186)83-239)180(288)219-112(45-50-136(188)243)158(266)224-122(65-91(6)7)166(274)216-117(55-62-290-20)161(269)229-127(71-101-80-198-87-205-101)170(278)232-130(74-138(190)245)173(281)222-120(63-89(2)3)151(259)203-82-141(248)207-106(39-27-30-56-183)152(260)228-126(70-100-79-197-86-204-100)169(277)226-124(67-93(10)11)167(275)230-131(75-139(191)246)174(282)235-134(85-241)177(285)217-116(54-61-289-19)160(268)213-113(46-51-142(249)250)156(264)211-110(43-34-60-201-182(195)196)162(270)236-146(95(14)15)178(286)218-114(47-52-143(251)252)159(267)227-125(69-99-78-202-105-38-26-25-37-103(99)105)168(276)225-123(66-92(8)9)164(272)212-109(42-33-59-200-181(193)194)154(262)209-107(40-28-31-57-184)153(261)210-108(41-29-32-58-185)155(263)223-121(64-90(4)5)165(273)214-111(44-49-135(187)242)157(265)233-132(77-145(255)256)175(283)237-147(96(16)17)179(287)234-128(72-102-81-199-88-206-102)171(279)231-129(73-137(189)244)172(280)221-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,104,106-134,146-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,248)(H,208,247)(H,209,262)(H,210,261)(H,211,264)(H,212,272)(H,213,268)(H,214,273)(H,215,284)(H,216,274)(H,217,285)(H,218,286)(H,219,288)(H,220,258)(H,221,280)(H,222,281)(H,223,263)(H,224,266)(H,225,276)(H,226,277)(H,227,267)(H,228,260)(H,229,269)(H,230,275)(H,231,279)(H,232,278)(H,233,265)(H,234,287)(H,235,282)(H,236,270)(H,237,283)(H,238,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,146-,147-,148-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.290n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.300n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP production


J Med Chem 53: 4332-53 (2010)


Article DOI: 10.1021/jm9018756
BindingDB Entry DOI: 10.7270/Q21R6QPF
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246339
PNG
(CHEMBL4106303)
Show SMILES CC[C@H](C)[C@H](NC(=O)C[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)CC(N)=O)Cc1ccccc1
Show InChI InChI=1S/C186H305N57O47/c1-23-101(16)153(240-146(254)81-118(89-244)218-160(267)120(47-34-37-61-189)220-147(255)88-207-159(266)119(46-33-36-60-188)223-175(282)137(83-151(262)263)236-174(281)134(75-116-86-202-93-210-116)234-171(278)129(68-98(10)11)230-169(276)128(67-97(8)9)229-164(271)124(52-55-139(191)247)226-173(280)133(74-115-85-201-92-209-115)232-166(273)126(54-58-149(258)259)227-178(285)138(90-245)238-179(286)152(100(14)15)241-157(264)105(20)190)181(288)228-125(53-56-140(192)248)165(272)235-136(82-150(260)261)168(275)216-112(65-95(4)5)79-143(251)219-121(48-38-62-204-184(194)195)162(269)225-123(50-40-64-206-186(198)199)163(270)224-122(49-39-63-205-185(196)197)161(268)217-113(71-108-41-28-26-29-42-108)80-144(252)222-131(72-109-43-30-27-31-44-109)172(279)231-130(69-99(12)13)170(277)233-132(73-114-84-200-91-208-114)167(274)215-110(45-32-35-59-187)77-142(250)221-127(66-96(6)7)176(283)242-155(103(18)25-3)180(287)213-106(21)158(265)214-111(51-57-148(256)257)78-145(253)239-154(102(17)24-2)182(289)237-135(76-117-87-203-94-211-117)177(284)243-156(107(22)246)183(290)212-104(19)70-141(193)249/h26-31,41-44,84-87,91-107,110-113,118-138,152-156,244-246H,23-25,32-40,45-83,88-90,187-190H2,1-22H3,(H2,191,247)(H2,192,248)(H2,193,249)(H,200,208)(H,201,209)(H,202,210)(H,203,211)(H,207,266)(H,212,290)(H,213,287)(H,214,265)(H,215,274)(H,216,275)(H,217,268)(H,218,267)(H,219,251)(H,220,255)(H,221,250)(H,222,252)(H,223,282)(H,224,270)(H,225,269)(H,226,280)(H,227,285)(H,228,288)(H,229,271)(H,230,276)(H,231,279)(H,232,273)(H,233,277)(H,234,278)(H,235,272)(H,236,281)(H,237,289)(H,238,286)(H,239,253)(H,240,254)(H,241,264)(H,242,283)(H,243,284)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H4,194,195,204)(H4,196,197,205)(H4,198,199,206)/t101-,102-,103-,104-,105-,106-,107+,110-,111-,112-,113-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,152-,153-,154-,155-,156-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.320n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246245
PNG
(CHEMBL4089035)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C190H307N61O46S2/c1-22-101(16)152(251-170(281)125(58-63-147(260)261)222-156(267)104(19)220-183(294)149(98(10)11)248-154(265)102(17)194)186(297)234-123(56-61-143(197)255)165(276)237-130(76-95(4)5)173(284)231-127(65-74-299-21)168(279)242-135(82-108-89-209-92-217-108)177(288)230-121(54-59-141(195)253)163(274)223-114(50-33-37-69-211-187(201)202)157(268)219-103(18)155(266)221-115(47-30-34-66-191)161(272)240-133(80-106-87-215-112-45-28-26-43-110(106)112)175(286)239-132(78-97(8)9)174(285)243-138(85-145(199)257)180(291)247-140(91-252)182(293)232-126(64-73-298-20)167(278)226-118(51-38-70-212-188(203)204)159(270)227-120(53-40-72-214-190(207)208)169(280)249-150(99(12)13)184(295)233-124(57-62-146(258)259)166(277)241-134(81-107-88-216-113-46-29-27-44-111(107)113)176(287)238-131(77-96(6)7)171(282)228-119(52-39-71-213-189(205)206)160(271)224-116(48-31-35-67-192)158(269)225-117(49-32-36-68-193)162(273)236-129(75-94(2)3)172(283)229-122(55-60-142(196)254)164(275)245-139(86-148(262)263)181(292)250-151(100(14)15)185(296)246-136(83-109-90-210-93-218-109)178(289)244-137(84-144(198)256)179(290)235-128(153(200)264)79-105-41-24-23-25-42-105/h23-29,41-46,87-90,92-104,114-140,149-152,215-216,252H,22,30-40,47-86,91,191-194H2,1-21H3,(H2,195,253)(H2,196,254)(H2,197,255)(H2,198,256)(H2,199,257)(H2,200,264)(H,209,217)(H,210,218)(H,219,268)(H,220,294)(H,221,266)(H,222,267)(H,223,274)(H,224,271)(H,225,269)(H,226,278)(H,227,270)(H,228,282)(H,229,283)(H,230,288)(H,231,284)(H,232,293)(H,233,295)(H,234,297)(H,235,290)(H,236,273)(H,237,276)(H,238,287)(H,239,286)(H,240,272)(H,241,277)(H,242,279)(H,243,285)(H,244,289)(H,245,275)(H,246,296)(H,247,291)(H,248,265)(H,249,280)(H,250,292)(H,251,281)(H,258,259)(H,260,261)(H,262,263)(H4,201,202,211)(H4,203,204,212)(H4,205,206,213)(H4,207,208,214)/t101-,102-,103-,104-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,149-,150-,151-,152-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.340n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246275
PNG
(CHEMBL4073243)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C182H293N55O49S2/c1-21-97(18)147(237-162(268)116(50-54-142(250)251)214-176(282)134(85-240)233-179(285)144(94(12)13)234-150(256)105(186)83-238)180(286)207-107-44-33-39-104(107)149(255)219-121(65-90(4)5)163(269)215-118(56-63-288-20)160(266)226-127(72-101-80-197-87-204-101)169(275)229-130(75-137(189)243)172(278)220-120(64-89(2)3)151(257)202-82-139(245)206-108(41-27-30-57-183)152(258)225-126(71-100-79-196-86-203-100)168(274)223-124(68-93(10)11)166(272)227-131(76-138(190)244)173(279)232-133(84-239)175(281)216-117(55-62-287-19)159(265)212-114(48-52-140(246)247)156(262)210-112(46-35-61-200-182(194)195)161(267)235-145(95(14)15)177(283)217-115(49-53-141(248)249)158(264)224-125(70-99-78-201-106-40-26-25-38-103(99)106)167(273)222-123(67-92(8)9)164(270)211-111(45-34-60-199-181(192)193)154(260)208-109(42-28-31-58-184)153(259)209-110(43-29-32-59-185)155(261)221-122(66-91(6)7)165(271)213-113(47-51-135(187)241)157(263)230-132(77-143(252)253)174(280)236-146(96(16)17)178(284)231-128(73-102-81-198-88-205-102)170(276)228-129(74-136(188)242)171(277)218-119(148(191)254)69-98-36-23-22-24-37-98/h22-26,36-38,40,78-81,86-97,104-105,107-134,144-147,201,238-240H,21,27-35,39,41-77,82-85,183-186H2,1-20H3,(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H2,191,254)(H,196,203)(H,197,204)(H,198,205)(H,202,257)(H,206,245)(H,207,286)(H,208,260)(H,209,259)(H,210,262)(H,211,270)(H,212,265)(H,213,271)(H,214,282)(H,215,269)(H,216,281)(H,217,283)(H,218,277)(H,219,255)(H,220,278)(H,221,261)(H,222,273)(H,223,274)(H,224,264)(H,225,258)(H,226,266)(H,227,272)(H,228,276)(H,229,275)(H,230,263)(H,231,284)(H,232,279)(H,233,285)(H,234,256)(H,235,267)(H,236,280)(H,237,268)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H4,192,193,199)(H4,194,195,200)/t97-,104-,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,144-,145-,146-,147-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.340n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246335
PNG
(CHEMBL4093590)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C182H304N54O46/c1-20-94(16)144(234-152(256)103-40-30-49-112(103)206-156(260)115(44-22-24-63-184)205-138(241)83-202-155(259)114(43-21-23-62-183)213-171(275)132(76-142(248)249)228-169(273)129(73-96-77-197-85-203-96)225-167(271)123(67-87(2)3)219-150(254)102-39-29-47-110(102)207-160(264)119(54-58-136(186)239)212-149(253)100-37-27-46-109(100)208-161(265)121(56-60-139(242)243)217-173(277)135(84-237)231-175(279)143(93(14)15)233-147(251)98-35-25-42-107(98)185)176(280)218-120(55-59-137(187)240)162(266)227-131(75-141(246)247)170(274)209-111-48-28-38-101(111)148(252)211-116(51-32-64-199-179(189)190)157(261)214-117(52-33-65-200-180(191)192)158(262)215-118(53-34-66-201-181(193)194)159(263)229-133-81-195-79-105(133)153(257)221-125(69-89(6)7)165(269)223-127(71-91(10)11)164(268)216-122(57-61-140(244)245)163(267)230-134-82-196-80-106(134)154(258)222-126(70-90(8)9)166(270)224-128(72-92(12)13)174(278)236-182(18,19)178(282)232-113-50-31-41-104(113)151(255)220-124(68-88(4)5)168(272)226-130(74-97-78-198-86-204-97)172(276)235-145(95(17)238)177(281)210-108-45-26-36-99(108)146(188)250/h77-78,85-95,98-135,143-145,195-196,237-238H,20-76,79-84,183-185H2,1-19H3,(H2,186,239)(H2,187,240)(H2,188,250)(H,197,203)(H,198,204)(H,202,259)(H,205,241)(H,206,260)(H,207,264)(H,208,265)(H,209,274)(H,210,281)(H,211,252)(H,212,253)(H,213,275)(H,214,261)(H,215,262)(H,216,268)(H,217,277)(H,218,280)(H,219,254)(H,220,255)(H,221,257)(H,222,258)(H,223,269)(H,224,270)(H,225,271)(H,226,272)(H,227,266)(H,228,273)(H,229,263)(H,230,267)(H,231,279)(H,232,282)(H,233,251)(H,234,256)(H,235,276)(H,236,278)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H4,189,190,199)(H4,191,192,200)(H4,193,194,201)/t94-,95+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,143-,144-,145-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.360n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246206
PNG
(CHEMBL4090894)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C194H309N61O46S2/c1-97(2)79-134(176(288)235-128(60-65-147(201)259)169(281)248-143(89-152(266)267)184(296)254-154(101(9)10)187(299)249-140(86-108-93-214-96-222-108)181(293)247-141(87-148(202)260)182(294)239-133(156(204)268)82-104-39-19-18-20-40-104)240-166(278)122(51-27-31-72-197)231-162(274)121(50-26-30-71-196)230-164(276)124(56-37-75-217-192(209)210)234-175(287)135(80-98(3)4)241-179(291)138(84-106-91-220-116-48-24-22-42-110(106)116)244-170(282)129(61-66-150(262)263)238-186(298)153(100(7)8)253-174(286)125(57-38-76-218-193(211)212)233-163(275)123(55-36-74-216-191(207)208)232-172(284)132(69-78-303-17)237-185(297)144(94-256)250-183(295)142(88-149(203)261)246-177(289)136(81-99(5)6)242-178(290)137(83-105-90-219-115-47-23-21-41-109(105)115)243-165(277)120(49-25-29-70-195)226-157(269)103(13)223-161(273)119(52-28-32-73-215-190(205)206)229-168(280)127(59-64-146(200)258)236-180(292)139(85-107-92-213-95-221-107)245-173(285)131(68-77-302-16)228-160(272)113-45-35-53-117(113)224-167(279)126(58-63-145(199)257)227-159(271)112-44-34-54-118(112)225-171(283)130(62-67-151(264)265)251-189(301)194(14,15)255-188(300)155(102(11)12)252-158(270)111-43-33-46-114(111)198/h18-24,39-42,47-48,90-93,95-103,111-114,117-144,153-155,219-220,256H,25-38,43-46,49-89,94,195-198H2,1-17H3,(H2,199,257)(H2,200,258)(H2,201,259)(H2,202,260)(H2,203,261)(H2,204,268)(H,213,221)(H,214,222)(H,223,273)(H,224,279)(H,225,283)(H,226,269)(H,227,271)(H,228,272)(H,229,280)(H,230,276)(H,231,274)(H,232,284)(H,233,275)(H,234,287)(H,235,288)(H,236,292)(H,237,297)(H,238,298)(H,239,294)(H,240,278)(H,241,291)(H,242,290)(H,243,277)(H,244,282)(H,245,285)(H,246,289)(H,247,293)(H,248,281)(H,249,299)(H,250,295)(H,251,301)(H,252,270)(H,253,286)(H,254,296)(H,255,300)(H,262,263)(H,264,265)(H,266,267)(H4,205,206,215)(H4,207,208,216)(H4,209,210,217)(H4,211,212,218)/t103-,111-,112-,113-,114-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,153-,154-,155-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246205
PNG
(CHEMBL4106300)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C196H319N61O46S2/c1-22-107(16)164(257-178(289)135(58-63-159(272)273)238-167(278)110(19)226-189(300)162(105(12)13)255-165(276)108(17)200)192(303)245-134(57-61-149(203)261)175(286)247-139(77-102(6)7)183(294)244-136(65-74-305-21)176(287)249-142(82-120-95-215-98-223-120)185(296)243-133(56-60-148(202)260)174(285)239-128(50-33-37-69-217-193(207)208)168(279)225-109(18)166(277)237-129(49-32-36-68-199)170(281)231-118(80-112-93-221-124-46-28-26-44-122(112)124)88-156(268)235-137(75-100(2)3)180(291)251-145(92-152(206)264)187(298)253-146(97-258)188(299)228-116(64-73-304-20)87-154(266)234-127(51-38-70-218-194(209)210)172(283)240-131(53-40-72-220-196(213)214)177(288)256-163(106(14)15)190(301)229-115(54-62-158(270)271)86-155(267)236-141(81-113-94-222-125-47-29-27-45-123(113)125)184(295)248-140(78-103(8)9)181(292)241-130(52-39-71-219-195(211)212)169(280)227-114(43-30-34-66-197)85-153(265)233-126(48-31-35-67-198)173(284)246-138(76-101(4)5)182(293)242-132(55-59-147(201)259)171(282)232-119(90-160(274)275)89-157(269)254-161(104(10)11)191(302)252-143(83-121-96-216-99-224-121)186(297)250-144(91-151(205)263)179(290)230-117(84-150(204)262)79-111-41-24-23-25-42-111/h23-29,41-42,44-47,93-96,98-110,114-119,126-146,161-164,221-222,258H,22,30-40,43,48-92,97,197-200H2,1-21H3,(H2,201,259)(H2,202,260)(H2,203,261)(H2,204,262)(H2,205,263)(H2,206,264)(H,215,223)(H,216,224)(H,225,279)(H,226,300)(H,227,280)(H,228,299)(H,229,301)(H,230,290)(H,231,281)(H,232,282)(H,233,265)(H,234,266)(H,235,268)(H,236,267)(H,237,277)(H,238,278)(H,239,285)(H,240,283)(H,241,292)(H,242,293)(H,243,296)(H,244,294)(H,245,303)(H,246,284)(H,247,286)(H,248,295)(H,249,287)(H,250,297)(H,251,291)(H,252,302)(H,253,298)(H,254,269)(H,255,276)(H,256,288)(H,257,289)(H,270,271)(H,272,273)(H,274,275)(H4,207,208,217)(H4,209,210,218)(H4,211,212,219)(H4,213,214,220)/t107-,108-,109-,110-,114-,115-,116-,117-,118-,119+,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.440n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246363
PNG
(CHEMBL4097878)
Show SMILES CSCC[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C188H309N61O42S/c1-91(2)73-130(234-156(264)107-41-30-51-116(107)219-161(269)120(45-19-22-66-189)224-151(259)97(13)217-160(268)119(47-21-24-68-210-184(198)199)229-167(275)127(59-63-143(194)253)233-175(283)134(77-99-82-208-89-215-99)238-169(277)129(65-72-292-16)228-155(263)105-39-28-49-114(105)220-165(273)125(57-61-141(192)251)227-154(262)104-38-27-50-115(104)222-168(276)128(60-64-146(256)257)245-183(291)188(14,15)249-182(290)149(96(11)12)247-152(260)102-36-25-43-111(102)191)173(281)239-137(80-145(196)255)178(286)244-140(88-250)179(287)223-117-52-29-40-106(117)153(261)225-122(54-32-69-211-185(200)201)162(270)230-124(56-34-71-213-187(204)205)170(278)248-148(95(9)10)181(289)243-139-87-207-85-110(139)159(267)235-133(76-98-81-214-112-44-18-17-35-101(98)112)174(282)237-132(75-93(5)6)171(279)231-123(55-33-70-212-186(202)203)164(272)242-138-86-206-84-109(138)158(266)226-121(46-20-23-67-190)163(271)236-131(74-92(3)4)172(280)232-126(58-62-142(193)252)166(274)221-118-53-31-42-108(118)157(265)246-147(94(7)8)180(288)241-135(78-100-83-209-90-216-100)176(284)240-136(79-144(195)254)177(285)218-113-48-26-37-103(113)150(197)258/h17-18,35,44,81-83,89-97,102-111,113-140,147-149,206-207,214,250H,19-34,36-43,45-80,84-88,189-191H2,1-16H3,(H2,192,251)(H2,193,252)(H2,194,253)(H2,195,254)(H2,196,255)(H2,197,258)(H,208,215)(H,209,216)(H,217,268)(H,218,285)(H,219,269)(H,220,273)(H,221,274)(H,222,276)(H,223,287)(H,224,259)(H,225,261)(H,226,266)(H,227,262)(H,228,263)(H,229,275)(H,230,270)(H,231,279)(H,232,280)(H,233,283)(H,234,264)(H,235,267)(H,236,271)(H,237,282)(H,238,277)(H,239,281)(H,240,284)(H,241,288)(H,242,272)(H,243,289)(H,244,286)(H,245,291)(H,246,265)(H,247,260)(H,248,278)(H,249,290)(H,256,257)(H4,198,199,210)(H4,200,201,211)(H4,202,203,212)(H4,204,205,213)/t97-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.480n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246370
PNG
(CHEMBL4059512)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C184H307N61O42S/c1-21-95(16)146(245-166(273)123(56-60-142(252)253)220-150(257)98(19)214-177(284)143(92(10)11)242-148(255)96(17)187)180(287)229-122(55-59-139(190)249)163(270)233-127(71-90(6)7)169(276)228-124(61-68-288-20)164(271)235-130(74-100-79-204-86-211-100)172(279)227-121(54-58-138(189)248)162(269)223-114(45-26-29-64-206-181(194)195)156(263)213-97(18)149(256)219-115(43-24-27-62-185)157(264)216-111-47-32-40-105(111)152(259)230-125(69-88(2)3)170(277)236-133(77-141(192)251)175(282)241-136(85-246)176(283)218-112-48-31-39-104(112)151(258)221-117(50-34-65-207-182(196)197)158(265)224-119(52-36-67-209-184(200)201)165(272)244-145(94(14)15)179(286)240-135-84-203-82-108(135)155(262)231-129(73-99-78-210-109-42-23-22-37-102(99)109)171(278)234-128(72-91(8)9)167(274)225-118(51-35-66-208-183(198)199)160(267)239-134-83-202-81-107(134)154(261)222-116(44-25-28-63-186)159(266)232-126(70-89(4)5)168(275)226-120(53-57-137(188)247)161(268)217-113-49-33-41-106(113)153(260)243-144(93(12)13)178(285)238-131(75-101-80-205-87-212-101)173(280)237-132(76-140(191)250)174(281)215-110-46-30-38-103(110)147(193)254/h22-23,37,42,78-80,86-98,103-108,110-136,143-146,202-203,210,246H,21,24-36,38-41,43-77,81-85,185-187H2,1-20H3,(H2,188,247)(H2,189,248)(H2,190,249)(H2,191,250)(H2,192,251)(H2,193,254)(H,204,211)(H,205,212)(H,213,263)(H,214,284)(H,215,281)(H,216,264)(H,217,268)(H,218,283)(H,219,256)(H,220,257)(H,221,258)(H,222,261)(H,223,269)(H,224,265)(H,225,274)(H,226,275)(H,227,279)(H,228,276)(H,229,287)(H,230,259)(H,231,262)(H,232,266)(H,233,270)(H,234,278)(H,235,271)(H,236,277)(H,237,280)(H,238,285)(H,239,267)(H,240,286)(H,241,282)(H,242,255)(H,243,260)(H,244,272)(H,245,273)(H,252,253)(H4,194,195,206)(H4,196,197,207)(H4,198,199,208)(H4,200,201,209)/t95-,96-,97-,98-,103-,104-,105-,106-,107-,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.510n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246338
PNG
(CHEMBL4063242)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C185H300N56O44/c1-17-94(12)146(179(282)210-97(15)151(254)212-114-50-32-44-108(114)156(259)239-148(96(14)19-3)181(284)233-133(75-102-80-202-89-209-102)176(279)241-149(98(16)243)182(285)217-113-49-28-40-104(113)150(191)253)240-175(278)129(71-92(8)9)226-158(261)111-82-199-84-137(111)235-172(275)132(74-101-79-201-88-208-101)230-169(272)128(70-91(6)7)228-170(273)130(72-99-37-21-20-22-38-99)227-159(262)110-81-198-83-136(110)234-164(267)123(57-36-68-205-185(196)197)222-163(266)122(56-35-67-204-184(194)195)221-162(265)121(55-34-66-203-183(192)193)218-153(256)106-42-30-53-117(106)216-173(276)134(76-143(249)250)231-167(270)125(59-62-140(190)245)224-180(283)147(95(13)18-2)238-157(260)109-45-33-54-118(109)213-161(264)120(48-24-26-65-187)211-141(246)85-206-160(263)119(47-23-25-64-186)220-174(277)135(77-144(251)252)232-171(274)131(73-100-78-200-87-207-100)229-168(271)127(69-90(4)5)225-155(258)107-43-31-52-116(107)214-165(268)124(58-61-139(189)244)219-154(257)105-41-29-51-115(105)215-166(269)126(60-63-142(247)248)223-177(280)138(86-242)236-178(281)145(93(10)11)237-152(255)103-39-27-46-112(103)188/h20-22,37-38,78-80,87-98,103-138,145-149,198-199,242-243H,17-19,23-36,39-77,81-86,186-188H2,1-16H3,(H2,189,244)(H2,190,245)(H2,191,253)(H,200,207)(H,201,208)(H,202,209)(H,206,263)(H,210,282)(H,211,246)(H,212,254)(H,213,264)(H,214,268)(H,215,269)(H,216,276)(H,217,285)(H,218,256)(H,219,257)(H,220,277)(H,221,265)(H,222,266)(H,223,280)(H,224,283)(H,225,258)(H,226,261)(H,227,262)(H,228,273)(H,229,271)(H,230,272)(H,231,270)(H,232,274)(H,233,284)(H,234,267)(H,235,275)(H,236,281)(H,237,255)(H,238,260)(H,239,259)(H,240,278)(H,241,279)(H,247,248)(H,249,250)(H,251,252)(H4,192,193,203)(H4,194,195,204)(H4,196,197,205)/t94-,95-,96-,97-,98+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,145-,146-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.510n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246384
PNG
(CHEMBL4069902)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C194H311N61O46S2/c1-20-103(14)155(254-173(285)129(62-67-150(264)265)250-189(301)194(16,17)255-188(300)154(102(12)13)251-158(270)112-45-36-47-114(112)198)187(299)237-127(60-65-146(201)259)166(278)224-117-54-37-46-113(117)159(271)226-130(68-77-302-18)171(283)244-138(85-108-92-213-95-221-108)179(291)234-125(58-63-144(199)257)167(279)227-118(53-31-35-73-215-190(205)206)160(272)223-104(15)157(269)225-119(50-28-32-70-195)164(276)242-136(83-106-90-219-115-48-26-24-43-110(106)115)177(289)241-135(81-99(6)7)176(288)245-141(88-148(203)261)182(294)249-143(94-256)184(296)235-131(69-78-303-19)170(282)230-122(55-38-74-216-191(207)208)162(274)231-124(57-40-76-218-193(211)212)172(284)252-152(100(8)9)185(297)236-128(61-66-149(262)263)169(281)243-137(84-107-91-220-116-49-27-25-44-111(107)116)178(290)240-134(80-98(4)5)174(286)232-123(56-39-75-217-192(209)210)163(275)228-120(51-29-33-71-196)161(273)229-121(52-30-34-72-197)165(277)239-133(79-97(2)3)175(287)233-126(59-64-145(200)258)168(280)247-142(89-151(266)267)183(295)253-153(101(10)11)186(298)248-139(86-109-93-214-96-222-109)180(292)246-140(87-147(202)260)181(293)238-132(156(204)268)82-105-41-22-21-23-42-105/h21-27,41-44,48-49,90-93,95-104,112-114,117-143,152-155,219-220,256H,20,28-40,45-47,50-89,94,195-198H2,1-19H3,(H2,199,257)(H2,200,258)(H2,201,259)(H2,202,260)(H2,203,261)(H2,204,268)(H,213,221)(H,214,222)(H,223,272)(H,224,278)(H,225,269)(H,226,271)(H,227,279)(H,228,275)(H,229,273)(H,230,282)(H,231,274)(H,232,286)(H,233,287)(H,234,291)(H,235,296)(H,236,297)(H,237,299)(H,238,293)(H,239,277)(H,240,290)(H,241,289)(H,242,276)(H,243,281)(H,244,283)(H,245,288)(H,246,292)(H,247,280)(H,248,298)(H,249,294)(H,250,301)(H,251,270)(H,252,284)(H,253,295)(H,254,285)(H,255,300)(H,262,263)(H,264,265)(H,266,267)(H4,205,206,215)(H4,207,208,216)(H4,209,210,217)(H4,211,212,218)/t103-,104-,112-,113-,114-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,152-,153-,154-,155-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.520n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246420
PNG
(CHEMBL4106304)
Show SMILES CC[C@H](C)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C182H296N58O44/c1-20-93(14)143(176(281)209-97(18)149(254)211-111-46-32-41-106(111)151(256)238-145(95(16)22-3)178(283)232-130(71-103-77-200-87-208-103)173(278)240-146(98(19)242)179(284)214-110-45-30-39-104(110)147(188)252)239-172(277)125(66-91(10)11)222-153(258)109-79-196-81-134(109)234-169(274)129(70-102-76-199-86-207-102)229-165(270)124(65-90(8)9)226-166(271)126(67-99-37-24-23-25-38-99)223-154(259)108-78-195-80-133(108)233-159(264)118(51-36-62-203-182(193)194)218-158(263)117(50-35-61-202-181(191)192)217-157(262)116(49-34-60-201-180(189)190)215-150(255)105-40-31-47-112(105)213-170(275)131(72-140(248)249)230-161(266)120(53-56-137(187)244)221-177(282)144(94(15)21-2)237-152(257)107-42-33-48-113(107)212-156(261)115(44-27-29-59-184)210-138(245)82-204-155(260)114(43-26-28-58-183)216-171(276)132(73-141(250)251)231-168(273)128(69-101-75-198-85-206-101)228-164(269)123(64-89(6)7)225-163(268)122(63-88(4)5)224-160(265)119(52-55-136(186)243)219-167(272)127(68-100-74-197-84-205-100)227-162(267)121(54-57-139(246)247)220-174(279)135(83-241)235-175(280)142(92(12)13)236-148(253)96(17)185/h23-25,37-38,74-77,84-98,104-135,142-146,195-196,241-242H,20-22,26-36,39-73,78-83,183-185H2,1-19H3,(H2,186,243)(H2,187,244)(H2,188,252)(H,197,205)(H,198,206)(H,199,207)(H,200,208)(H,204,260)(H,209,281)(H,210,245)(H,211,254)(H,212,261)(H,213,275)(H,214,284)(H,215,255)(H,216,276)(H,217,262)(H,218,263)(H,219,272)(H,220,279)(H,221,282)(H,222,258)(H,223,259)(H,224,265)(H,225,268)(H,226,271)(H,227,267)(H,228,269)(H,229,270)(H,230,266)(H,231,273)(H,232,283)(H,233,264)(H,234,274)(H,235,280)(H,236,253)(H,237,257)(H,238,256)(H,239,277)(H,240,278)(H,246,247)(H,248,249)(H,250,251)(H4,189,190,201)(H4,191,192,202)(H4,193,194,203)/t93-,94-,95-,96-,97-,98+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,142-,143+,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.650n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246385
PNG
(CHEMBL4083799)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C183H297N55O45S/c1-18-94(16)148(238-166(268)121(54-58-144(249)250)219-177(279)136(84-240)234-180(282)146(92(12)13)235-150(252)99-34-25-40-107(99)186)181(283)220-119(52-56-138(188)242)162(264)210-110-45-27-36-101(110)152(254)215-122(59-64-284-17)164(266)226-128(70-96-76-199-85-205-96)171(273)229-131(73-140(190)244)174(276)223-123(65-87(2)3)157(259)204-82-142(246)207-114(42-21-23-60-184)158(260)209-111-46-29-38-103(111)153(255)221-124(66-88(4)5)169(271)227-132(74-141(191)245)175(277)233-135(83-239)176(278)212-112-47-28-37-102(112)151(253)214-120(53-57-143(247)248)163(265)216-117(50-32-63-202-183(195)196)165(267)237-147(93(14)15)179(281)232-134-81-198-79-106(134)156(258)222-127(69-95-75-203-108-41-20-19-33-98(95)108)170(272)225-126(68-90(8)9)167(269)217-116(49-31-62-201-182(193)194)160(262)231-133-80-197-78-105(133)155(257)213-115(43-22-24-61-185)159(261)224-125(67-89(6)7)168(270)218-118(51-55-137(187)241)161(263)211-113-48-30-39-104(113)154(256)236-145(91(10)11)178(280)230-129(71-97-77-200-86-206-97)172(274)228-130(72-139(189)243)173(275)208-109-44-26-35-100(109)149(192)251/h19-20,33,41,75-77,85-94,99-107,109-136,145-148,197-198,203,239-240H,18,21-32,34-40,42-74,78-84,184-186H2,1-17H3,(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,251)(H,199,205)(H,200,206)(H,204,259)(H,207,246)(H,208,275)(H,209,260)(H,210,264)(H,211,263)(H,212,278)(H,213,257)(H,214,253)(H,215,254)(H,216,265)(H,217,269)(H,218,270)(H,219,279)(H,220,283)(H,221,255)(H,222,258)(H,223,276)(H,224,261)(H,225,272)(H,226,266)(H,227,271)(H,228,274)(H,229,273)(H,230,280)(H,231,262)(H,232,281)(H,233,277)(H,234,282)(H,235,252)(H,236,256)(H,237,267)(H,238,268)(H,247,248)(H,249,250)(H4,193,194,201)(H4,195,196,202)/t94-,99-,100-,101-,102-,103-,104-,105-,106-,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,145-,146-,147-,148-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.710n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246425
PNG
(CHEMBL4106302)
Show SMILES CSCC[C@@H](CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C
Show InChI InChI=1S/C200H321N61O46S2/c1-103(2)79-142(238-160(272)91-117(83-111-96-225-127-48-23-21-42-121(111)127)234-174(286)134(51-27-31-72-203)242-168(280)109(13)229-172(284)133(52-28-32-73-221-196(211)212)245-179(291)139(61-65-153(207)265)249-188(300)146(85-119-98-219-101-227-119)252-181(293)141(69-78-309-17)244-171(283)125-46-35-53-129(125)240-178(290)138(60-64-152(206)264)243-170(282)124-45-34-54-130(124)241-180(292)140(62-67-163(276)277)257-195(307)200(14,15)261-194(306)167(108(11)12)259-169(281)123-44-33-47-126(123)204)184(296)254-149(95-156(210)268)190(302)256-150(100-262)191(303)231-115(68-77-308-16)90-158(270)237-132(55-36-74-222-197(213)214)176(288)246-136(57-38-76-224-199(217)218)182(294)260-166(107(9)10)192(304)232-114(58-66-162(274)275)89-159(271)239-145(84-112-97-226-128-49-24-22-43-122(112)128)187(299)251-144(81-105(5)6)185(297)247-135(56-37-75-223-198(215)216)173(285)230-113(41-25-29-70-201)88-157(269)236-131(50-26-30-71-202)177(289)250-143(80-104(3)4)186(298)248-137(59-63-151(205)263)175(287)235-118(93-164(278)279)92-161(273)258-165(106(7)8)193(305)255-147(86-120-99-220-102-228-120)189(301)253-148(94-155(209)267)183(295)233-116(87-154(208)266)82-110-39-19-18-20-40-110/h18-24,39-40,42-43,48-49,96-99,101-109,113-118,123-126,129-150,165-167,225-226,262H,25-38,41,44-47,50-95,100,201-204H2,1-17H3,(H2,205,263)(H2,206,264)(H2,207,265)(H2,208,266)(H2,209,267)(H2,210,268)(H,219,227)(H,220,228)(H,229,284)(H,230,285)(H,231,303)(H,232,304)(H,233,295)(H,234,286)(H,235,287)(H,236,269)(H,237,270)(H,238,272)(H,239,271)(H,240,290)(H,241,292)(H,242,280)(H,243,282)(H,244,283)(H,245,291)(H,246,288)(H,247,297)(H,248,298)(H,249,300)(H,250,289)(H,251,299)(H,252,293)(H,253,301)(H,254,296)(H,255,305)(H,256,302)(H,257,307)(H,258,273)(H,259,281)(H,260,294)(H,261,306)(H,274,275)(H,276,277)(H,278,279)(H4,211,212,221)(H4,213,214,222)(H4,215,216,223)(H4,217,218,224)/t109-,113-,114-,115-,116-,117-,118+,123-,124-,125-,126-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,165-,166-,167-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.790n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246369
PNG
(CHEMBL4106301)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C200H323N61O46S2/c1-20-109(14)167(260-181(293)139(62-67-162(276)277)256-195(307)200(16,17)261-194(306)166(108(12)13)258-169(281)124-46-36-48-126(124)204)193(305)248-138(61-65-152(207)265)177(289)240-129-54-37-47-125(129)170(282)242-140(69-78-309-19)179(291)251-145(85-120-98-219-101-227-120)187(299)247-137(60-64-151(206)264)178(290)243-132(53-31-35-73-221-196(211)212)171(283)229-110(15)168(280)241-133(52-30-34-72-203)173(285)234-118(83-112-96-225-127-49-26-24-44-122(112)127)91-159(272)238-141(79-103(2)3)183(295)253-148(95-155(210)268)189(301)255-149(100-262)190(302)231-116(68-77-308-18)90-157(270)237-131(55-38-74-222-197(213)214)175(287)244-135(57-40-76-224-199(217)218)180(292)259-165(107(10)11)191(303)232-115(58-66-161(274)275)89-158(271)239-144(84-113-97-226-128-50-27-25-45-123(113)128)186(298)250-143(81-105(6)7)184(296)245-134(56-39-75-223-198(215)216)172(284)230-114(43-28-32-70-201)88-156(269)236-130(51-29-33-71-202)176(288)249-142(80-104(4)5)185(297)246-136(59-63-150(205)263)174(286)235-119(93-163(278)279)92-160(273)257-164(106(8)9)192(304)254-146(86-121-99-220-102-228-121)188(300)252-147(94-154(209)267)182(294)233-117(87-153(208)266)82-111-41-22-21-23-42-111/h21-27,41-42,44-45,49-50,96-99,101-110,114-119,124-126,129-149,164-167,225-226,262H,20,28-40,43,46-48,51-95,100,201-204H2,1-19H3,(H2,205,263)(H2,206,264)(H2,207,265)(H2,208,266)(H2,209,267)(H2,210,268)(H,219,227)(H,220,228)(H,229,283)(H,230,284)(H,231,302)(H,232,303)(H,233,294)(H,234,285)(H,235,286)(H,236,269)(H,237,270)(H,238,272)(H,239,271)(H,240,289)(H,241,280)(H,242,282)(H,243,290)(H,244,287)(H,245,296)(H,246,297)(H,247,299)(H,248,305)(H,249,288)(H,250,298)(H,251,291)(H,252,300)(H,253,295)(H,254,304)(H,255,301)(H,256,307)(H,257,273)(H,258,281)(H,259,292)(H,260,293)(H,261,306)(H,274,275)(H,276,277)(H,278,279)(H4,211,212,221)(H4,213,214,222)(H4,215,216,223)(H4,217,218,224)/t109-,110-,114-,115-,116-,117-,118-,119+,124-,125-,126-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,164-,165-,166-,167-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.830n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269978
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.920n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization


J Med Chem 53: 4332-53 (2010)


Article DOI: 10.1021/jm9018756
BindingDB Entry DOI: 10.7270/Q21R6QPF
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246295
PNG
(CHEMBL4060554)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)CC(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C182H294N56O50S2/c1-21-97(18)148(238-163(271)116(48-53-143(253)254)216-176(284)133(85-241)234-179(287)145(94(12)13)235-150(258)105(186)83-239)180(288)219-112(44-49-134(187)242)152(260)207-100(63-89(2)3)73-139(247)208-117(54-61-289-19)160(268)227-126(71-102-80-198-87-205-102)169(277)230-129(75-137(190)245)172(280)221-120(64-90(4)5)151(259)203-82-140(248)209-107(39-27-30-56-183)153(261)226-125(70-101-79-197-86-204-101)168(276)224-123(67-93(10)11)166(274)228-130(76-138(191)246)173(281)233-132(84-240)175(283)217-118(55-62-290-20)161(269)214-114(46-51-141(249)250)157(265)212-111(43-34-60-201-182(195)196)162(270)236-146(95(14)15)177(285)218-115(47-52-142(251)252)159(267)225-124(69-99-78-202-106-38-26-25-37-104(99)106)167(275)223-122(66-92(8)9)164(272)213-110(42-33-59-200-181(193)194)155(263)210-108(40-28-31-57-184)154(262)211-109(41-29-32-58-185)156(264)222-121(65-91(6)7)165(273)215-113(45-50-135(188)243)158(266)231-131(77-144(255)256)174(282)237-147(96(16)17)178(286)232-127(72-103-81-199-88-206-103)170(278)229-128(74-136(189)244)171(279)220-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,100,105,107-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,260)(H,208,247)(H,209,248)(H,210,263)(H,211,262)(H,212,265)(H,213,272)(H,214,269)(H,215,273)(H,216,284)(H,217,283)(H,218,285)(H,219,288)(H,220,279)(H,221,280)(H,222,264)(H,223,275)(H,224,276)(H,225,267)(H,226,261)(H,227,268)(H,228,274)(H,229,278)(H,230,277)(H,231,266)(H,232,286)(H,233,281)(H,234,287)(H,235,258)(H,236,270)(H,237,282)(H,238,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,100-,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269977
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246364
PNG
(CHEMBL4090161)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(N)=O
Show InChI InChI=1S/C188H311N61O42S/c1-19-97(14)149(248-169(277)127(60-64-145(256)257)244-183(291)188(16,17)249-182(290)148(96(12)13)246-152(260)103-38-28-44-111(103)191)181(289)232-126(59-63-142(194)253)165(273)220-114-50-30-40-105(114)154(262)226-128(65-72-292-18)167(275)237-133(77-100-82-208-89-215-100)174(282)231-125(58-62-141(193)252)166(274)227-118(48-24-27-68-210-184(198)199)159(267)217-98(15)151(259)223-119(46-22-25-66-189)160(268)219-115-51-32-42-107(115)155(263)233-129(73-91(2)3)172(280)238-136(80-144(196)255)177(285)243-139(88-250)178(286)222-116-52-31-41-106(116)153(261)224-121(54-34-69-211-185(200)201)161(269)228-123(56-36-71-213-187(204)205)168(276)247-147(95(10)11)180(288)242-138-87-207-85-110(138)158(266)234-132(76-99-81-214-112-45-21-20-37-102(99)112)173(281)236-131(75-93(6)7)170(278)229-122(55-35-70-212-186(202)203)163(271)241-137-86-206-84-109(137)157(265)225-120(47-23-26-67-190)162(270)235-130(74-92(4)5)171(279)230-124(57-61-140(192)251)164(272)221-117-53-33-43-108(117)156(264)245-146(94(8)9)179(287)240-134(78-101-83-209-90-216-101)175(283)239-135(79-143(195)254)176(284)218-113-49-29-39-104(113)150(197)258/h20-21,37,45,81-83,89-98,103-111,113-139,146-149,206-207,214,250H,19,22-36,38-44,46-80,84-88,189-191H2,1-18H3,(H2,192,251)(H2,193,252)(H2,194,253)(H2,195,254)(H2,196,255)(H2,197,258)(H,208,215)(H,209,216)(H,217,267)(H,218,284)(H,219,268)(H,220,273)(H,221,272)(H,222,286)(H,223,259)(H,224,261)(H,225,265)(H,226,262)(H,227,274)(H,228,269)(H,229,278)(H,230,279)(H,231,282)(H,232,289)(H,233,263)(H,234,266)(H,235,270)(H,236,281)(H,237,275)(H,238,280)(H,239,283)(H,240,287)(H,241,271)(H,242,288)(H,243,285)(H,244,291)(H,245,264)(H,246,260)(H,247,276)(H,248,277)(H,249,290)(H,256,257)(H4,198,199,210)(H4,200,201,211)(H4,202,203,212)(H4,204,205,213)/t97-,98-,103-,104-,105-,106-,107-,108-,109-,110-,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,146-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.80n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246248
PNG
(CHEMBL4106298)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C195H309N55O49S2/c1-19-106(16)166(250-178(284)133(56-61-161(269)270)235-189(295)146(96-252)246-192(298)165(105(14)15)248-167(273)120-42-33-44-122(120)199)193(299)236-132(54-58-148(201)254)175(281)230-125-49-34-43-121(125)168(274)231-134(63-70-301-18)176(282)240-140(78-116-92-210-97-217-116)184(290)243-143(88-151(204)257)186(292)237-135(71-99(2)3)169(275)216-94-158(264)227-126(47-28-31-65-197)170(276)223-114(76-108-90-214-123-45-25-23-40-118(108)123)84-156(262)228-136(72-100(4)5)180(286)242-144(89-152(205)258)187(293)245-145(95-251)188(294)220-112(62-69-300-17)83-154(260)226-130(55-60-160(267)268)174(280)232-129(51-36-68-213-195(208)209)177(283)249-164(104(12)13)190(296)221-111(52-59-159(265)266)82-155(261)229-139(77-109-91-215-124-46-26-24-41-119(109)124)183(289)239-138(74-102(8)9)181(287)233-128(50-35-67-212-194(206)207)171(277)219-110(39-27-30-64-196)81-153(259)225-127(48-29-32-66-198)173(279)238-137(73-101(6)7)182(288)234-131(53-57-147(200)253)172(278)224-115(86-162(271)272)85-157(263)247-163(103(10)11)191(297)244-141(79-117-93-211-98-218-117)185(291)241-142(87-150(203)256)179(285)222-113(80-149(202)255)75-107-37-21-20-22-38-107/h20-26,37-38,40-41,45-46,90-93,97-106,110-115,120-122,125-146,163-166,214-215,251-252H,19,27-36,39,42-44,47-89,94-96,196-199H2,1-18H3,(H2,200,253)(H2,201,254)(H2,202,255)(H2,203,256)(H2,204,257)(H2,205,258)(H,210,217)(H,211,218)(H,216,275)(H,219,277)(H,220,294)(H,221,296)(H,222,285)(H,223,276)(H,224,278)(H,225,259)(H,226,260)(H,227,264)(H,228,262)(H,229,261)(H,230,281)(H,231,274)(H,232,280)(H,233,287)(H,234,288)(H,235,295)(H,236,299)(H,237,292)(H,238,279)(H,239,289)(H,240,282)(H,241,291)(H,242,286)(H,243,290)(H,244,297)(H,245,293)(H,246,298)(H,247,263)(H,248,273)(H,249,283)(H,250,284)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H4,206,207,212)(H4,208,209,213)/t106-,110-,111-,112-,113-,114-,115+,120-,121-,122-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,163-,164-,165-,166-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.80n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50331022
PNG
((7S,10S,13S,16S,19S,22S,25S,28S)-13-((1H-imidazol-...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C59H103N19O15/c1-12-14-17-35(47(84)74-40(27-33-28-66-29-68-33)52(89)71-36(19-22-41(60)79)48(85)69-34(46(62)83)18-15-16-25-67-57(63)64)70-51(88)39(26-30(3)4)73-49(86)37(20-23-42(61)80)72-53(90)45(32(7)13-2)76-50(87)38(21-24-43(81)82)75-56(93)59(10,11)78-54(91)44(31(5)6)77-55(92)58(8,9)65/h28-32,34-40,44-45H,12-27,65H2,1-11H3,(H2,60,79)(H2,61,80)(H2,62,83)(H,66,68)(H,69,85)(H,70,88)(H,71,89)(H,72,90)(H,73,86)(H,74,84)(H,75,93)(H,76,87)(H,77,92)(H,78,91)(H,81,82)(H4,63,64,67)/t32-,34-,35-,36-,37-,38-,39-,40-,44-,45-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.40n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)


Article DOI: 10.1021/jm1008264
BindingDB Entry DOI: 10.7270/Q2GM87KQ
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human PTHR1 expressed in HKRKB7 cells assessed as accumulation of intracellular cAMP after 20 mins by enzyme immunoassay


J Med Chem 61: 5949-5962 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00182
BindingDB Entry DOI: 10.7270/Q2ZC85GG
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50511178
PNG
(CHEMBL4473665)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NC(Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)NC(CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIA


J Med Chem 63: 5089-5099 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01743
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246296
PNG
(CHEMBL4098506)
Show SMILES CC[C@H](C)[C@@H](CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C
Show InChI InChI=1S/C182H294N56O50S2/c1-21-97(18)118(219-158(266)114(47-52-143(251)252)215-177(285)134(85-241)235-180(288)146(94(12)13)236-150(258)104(186)83-239)76-140(247)207-111(44-49-135(187)242)156(264)223-122(65-91(6)7)166(274)216-117(55-62-290-20)162(270)228-127(71-101-80-198-87-205-101)170(278)231-130(74-138(190)245)173(281)221-120(63-89(2)3)151(259)203-82-141(248)208-106(39-27-30-56-183)152(260)227-126(70-100-79-197-86-204-100)169(277)225-124(67-93(10)11)167(275)229-131(75-139(191)246)174(282)234-133(84-240)176(284)217-116(54-61-289-19)161(269)213-113(46-51-142(249)250)157(265)211-110(43-34-60-201-182(195)196)163(271)237-147(95(14)15)178(286)218-115(48-53-144(253)254)160(268)226-125(69-99-78-202-105-38-26-25-37-103(99)105)168(276)224-123(66-92(8)9)164(272)212-109(42-33-59-200-181(193)194)154(262)209-107(40-28-31-57-184)153(261)210-108(41-29-32-58-185)155(263)222-121(64-90(4)5)165(273)214-112(45-50-136(188)243)159(267)232-132(77-145(255)256)175(283)238-148(96(16)17)179(287)233-128(72-102-81-199-88-206-102)171(279)230-129(73-137(189)244)172(280)220-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,104,106-134,146-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,247)(H,208,248)(H,209,262)(H,210,261)(H,211,265)(H,212,272)(H,213,269)(H,214,273)(H,215,285)(H,216,274)(H,217,284)(H,218,286)(H,219,266)(H,220,280)(H,221,281)(H,222,263)(H,223,264)(H,224,276)(H,225,277)(H,226,268)(H,227,260)(H,228,270)(H,229,275)(H,230,279)(H,231,278)(H,232,267)(H,233,287)(H,234,282)(H,235,288)(H,236,258)(H,237,271)(H,238,283)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,146-,147-,148-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.60n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246386
PNG
(CHEMBL4059923)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCC[C@@H]1N)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C184H292N56O49S2/c1-90(2)67-123(224-175(282)132(77-140(192)246)233-172(279)129(74-100-82-200-88-207-100)230-165(272)120(58-65-290-15)213-153(260)105-38-30-45-109(105)210-159(266)115(48-53-137(189)243)212-152(259)104-37-29-44-108(104)211-160(267)117(50-55-143(249)250)220-179(286)136(86-242)237-182(289)147(94(9)10)238-151(258)103-36-28-39-106(103)188)154(261)205-84-142(248)209-110(41-22-25-60-185)155(262)229-128(73-99-81-199-87-206-99)171(278)227-126(70-93(7)8)169(276)231-133(78-141(193)247)176(283)236-135(85-241)178(285)221-121(59-66-291-16)164(271)218-118(51-56-144(251)252)161(268)216-114(47-32-64-203-184(197)198)166(273)239-148(95(11)12)180(287)222-119(52-57-145(253)254)163(270)228-127(72-98-80-204-107-40-21-20-35-102(98)107)170(277)226-125(69-92(5)6)167(274)217-113(46-31-63-202-183(195)196)157(264)214-111(42-23-26-61-186)156(263)215-112(43-24-27-62-187)158(265)225-124(68-91(3)4)168(275)219-116(49-54-138(190)244)162(269)234-134(79-146(255)256)177(284)240-149(96(13)14)181(288)235-130(75-101-83-201-89-208-101)173(280)232-131(76-139(191)245)174(281)223-122(150(194)257)71-97-33-18-17-19-34-97/h17-21,33-35,40,80-83,87-96,103-106,108-136,147-149,204,241-242H,22-32,36-39,41-79,84-86,185-188H2,1-16H3,(H2,189,243)(H2,190,244)(H2,191,245)(H2,192,246)(H2,193,247)(H2,194,257)(H,199,206)(H,200,207)(H,201,208)(H,205,261)(H,209,248)(H,210,266)(H,211,267)(H,212,259)(H,213,260)(H,214,264)(H,215,263)(H,216,268)(H,217,274)(H,218,271)(H,219,275)(H,220,286)(H,221,285)(H,222,287)(H,223,281)(H,224,282)(H,225,265)(H,226,277)(H,227,278)(H,228,270)(H,229,262)(H,230,272)(H,231,276)(H,232,280)(H,233,279)(H,234,269)(H,235,288)(H,236,283)(H,237,289)(H,238,258)(H,239,273)(H,240,284)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,202)(H4,197,198,203)/t103-,104-,105-,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246336
PNG
(CHEMBL4106305)
Show SMILES CC[C@H](C)[C@H](NC(=O)C[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)CC(N)=O
Show InChI InChI=1S/C180H312N56O49/c1-26-99(20)148(233-140(247)78-110(85-237)209-152(261)112(41-30-34-58-184)212-141(248)84-201-151(260)111(40-29-33-57-183)216-169(278)131(80-146(257)258)231-168(277)128(72-108-82-196-88-203-108)228-166(275)125(68-96(14)15)225-165(274)124(67-95(12)13)223-157(266)116(46-50-133(186)240)219-167(276)127(71-107-81-195-87-202-107)227-159(268)119(49-54-144(253)254)221-171(280)132(86-238)232-173(282)147(98(18)19)234-150(259)101(22)185)174(283)222-117(47-51-134(187)241)158(267)230-130(79-145(255)256)160(269)208-106(62-90(2)3)77-139(246)211-113(42-35-59-198-177(189)190)155(264)218-115(44-37-61-200-179(193)194)156(265)217-114(43-36-60-199-178(191)192)153(262)207-105(45-52-142(249)250)76-138(245)215-120(63-91(4)5)161(270)224-123(66-94(10)11)164(273)220-118(48-53-143(251)252)154(263)206-103(38-27-31-55-181)74-136(243)213-121(64-92(6)7)162(271)226-126(69-97(16)17)172(281)236-180(24,25)176(285)210-104(39-28-32-56-182)75-137(244)214-122(65-93(8)9)163(272)229-129(73-109-83-197-89-204-109)170(279)235-149(102(23)239)175(284)205-100(21)70-135(188)242/h81-83,87-106,110-132,147-149,237-239H,26-80,84-86,181-185H2,1-25H3,(H2,186,240)(H2,187,241)(H2,188,242)(H,195,202)(H,196,203)(H,197,204)(H,201,260)(H,205,284)(H,206,263)(H,207,262)(H,208,269)(H,209,261)(H,210,285)(H,211,246)(H,212,248)(H,213,243)(H,214,244)(H,215,245)(H,216,278)(H,217,265)(H,218,264)(H,219,276)(H,220,273)(H,221,280)(H,222,283)(H,223,266)(H,224,270)(H,225,274)(H,226,271)(H,227,268)(H,228,275)(H,229,272)(H,230,267)(H,231,277)(H,232,282)(H,233,247)(H,234,259)(H,235,279)(H,236,281)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H4,189,190,198)(H4,191,192,199)(H4,193,194,200)/t99-,100-,101-,102+,103-,104-,105-,106-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,147-,148-,149-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 4.10n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50517884
PNG
(CHEMBL439458)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](\C=C(/F)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C190H306FN57O50S2/c1-25-101(20)154(248-169(279)122(52-57-149(261)262)224-183(293)139(87-249)243-156(266)110(97(12)13)77-111(191)102(21)195)188(298)228-119(49-54-142(197)252)164(274)231-127(69-94(6)7)172(282)225-124(59-66-300-24)167(277)237-133(75-107-84-207-90-214-107)176(286)239-135(78-143(198)253)178(288)229-125(67-92(2)3)157(267)212-86-146(256)217-113(43-31-34-60-192)158(268)236-132(74-106-83-206-89-213-106)175(285)233-129(71-96(10)11)173(283)238-137(80-145(200)255)180(290)244-140(88-250)184(294)226-123(58-65-299-23)166(276)222-120(50-55-147(257)258)162(272)220-117(47-38-64-210-190(204)205)168(278)245-152(99(16)17)186(296)227-121(51-56-148(259)260)165(275)235-131(73-105-82-211-112-42-30-29-41-109(105)112)174(284)232-128(70-95(8)9)170(280)221-116(46-37-63-209-189(202)203)160(270)218-114(44-32-35-61-193)159(269)219-115(45-33-36-62-194)161(271)230-126(68-93(4)5)171(281)223-118(48-53-141(196)251)163(273)241-138(81-150(263)264)182(292)247-153(100(18)19)187(297)242-134(76-108-85-208-91-215-108)177(287)240-136(79-144(199)254)179(289)234-130(72-104-39-27-26-28-40-104)181(291)246-151(98(14)15)185(295)216-103(22)155(201)265/h26-30,39-42,77,82-85,89-103,110,113-140,151-154,211,249-250H,25,31-38,43-76,78-81,86-88,192-195H2,1-24H3,(H2,196,251)(H2,197,252)(H2,198,253)(H2,199,254)(H2,200,255)(H2,201,265)(H,206,213)(H,207,214)(H,208,215)(H,212,267)(H,216,295)(H,217,256)(H,218,270)(H,219,269)(H,220,272)(H,221,280)(H,222,276)(H,223,281)(H,224,293)(H,225,282)(H,226,294)(H,227,296)(H,228,298)(H,229,288)(H,230,271)(H,231,274)(H,232,284)(H,233,285)(H,234,289)(H,235,275)(H,236,268)(H,237,277)(H,238,283)(H,239,286)(H,240,287)(H,241,273)(H,242,297)(H,243,266)(H,244,290)(H,245,278)(H,246,291)(H,247,292)(H,248,279)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H4,202,203,209)(H4,204,205,210)/b111-77-/t101-,102-,103-,110-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,151-,152-,153-,154-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.40n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP production


J Med Chem 61: 5822-5880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01788
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50246418
PNG
(CHEMBL4091191)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C182H294N56O50S2/c1-21-97(18)148(238-163(271)112(46-51-141(249)250)208-139(247)73-103(83-239)207-177(285)145(94(12)13)235-150(258)105(186)84-240)180(288)219-114(45-50-135(188)243)158(266)223-122(65-91(6)7)166(274)216-118(55-62-290-20)161(269)228-127(71-101-80-198-87-205-101)170(278)231-130(75-137(190)245)173(281)221-120(63-89(2)3)151(259)203-82-140(248)209-107(39-27-30-56-183)152(260)227-126(70-100-79-197-86-204-100)169(277)225-124(67-93(10)11)167(275)229-131(76-138(191)246)174(282)234-133(85-241)176(284)217-117(54-61-289-19)160(268)214-115(47-52-142(251)252)156(264)212-111(43-34-60-201-182(195)196)162(270)236-146(95(14)15)178(286)218-116(48-53-143(253)254)159(267)226-125(69-99-78-202-106-38-26-25-37-104(99)106)168(276)224-123(66-92(8)9)164(272)213-110(42-33-59-200-181(193)194)154(262)210-108(40-28-31-57-184)153(261)211-109(41-29-32-58-185)155(263)222-121(64-90(4)5)165(273)215-113(44-49-134(187)242)157(265)232-132(77-144(255)256)175(283)237-147(96(16)17)179(287)233-128(72-102-81-199-88-206-102)171(279)230-129(74-136(189)244)172(280)220-119(149(192)257)68-98-35-23-22-24-36-98/h22-26,35-38,78-81,86-97,103,105,107-133,145-148,202,239-241H,21,27-34,39-77,82-85,183-186H2,1-20H3,(H2,187,242)(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,257)(H,197,204)(H,198,205)(H,199,206)(H,203,259)(H,207,285)(H,208,247)(H,209,248)(H,210,262)(H,211,261)(H,212,264)(H,213,272)(H,214,268)(H,215,273)(H,216,274)(H,217,284)(H,218,286)(H,219,288)(H,220,280)(H,221,281)(H,222,263)(H,223,266)(H,224,276)(H,225,277)(H,226,267)(H,227,260)(H,228,269)(H,229,275)(H,230,279)(H,231,278)(H,232,265)(H,233,287)(H,234,282)(H,235,258)(H,236,270)(H,237,283)(H,238,271)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,200)(H4,195,196,201)/t97-,103+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEBI
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP after 12 to 20 mins by luciferase reporter gene ...


J Med Chem 60: 8816-8833 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00876
BindingDB Entry DOI: 10.7270/Q2FX7CWT
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50517885
PNG
(CHEMBL424859)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)\C=C(/Cl)[C@H](C)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C188H302ClN57O50S2/c1-24-99(18)152(246-167(277)120(51-56-147(259)260)222-181(291)137(86-247)241-154(264)100(19)71-109(189)101(20)193)186(296)226-117(48-53-140(195)250)162(272)229-125(68-93(6)7)170(280)223-122(58-65-298-23)165(275)235-131(75-106-83-205-89-212-106)174(284)237-133(77-141(196)251)176(286)227-123(66-91(2)3)155(265)210-85-144(254)215-111(42-30-33-59-190)156(266)234-130(74-105-82-204-88-211-105)173(283)231-127(70-95(10)11)171(281)236-135(79-143(198)253)178(288)242-138(87-248)182(292)224-121(57-64-297-22)164(274)220-118(49-54-145(255)256)160(270)218-115(46-37-63-208-188(202)203)166(276)243-150(97(14)15)184(294)225-119(50-55-146(257)258)163(273)233-129(73-104-81-209-110-41-29-28-40-108(104)110)172(282)230-126(69-94(8)9)168(278)219-114(45-36-62-207-187(200)201)158(268)216-112(43-31-34-60-191)157(267)217-113(44-32-35-61-192)159(269)228-124(67-92(4)5)169(279)221-116(47-52-139(194)249)161(271)239-136(80-148(261)262)180(290)245-151(98(16)17)185(295)240-132(76-107-84-206-90-213-107)175(285)238-134(78-142(197)252)177(287)232-128(72-103-38-26-25-27-39-103)179(289)244-149(96(12)13)183(293)214-102(21)153(199)263/h25-29,38-41,71,81-84,88-102,111-138,149-152,209,247-248H,24,30-37,42-70,72-80,85-87,190-193H2,1-23H3,(H2,194,249)(H2,195,250)(H2,196,251)(H2,197,252)(H2,198,253)(H2,199,263)(H,204,211)(H,205,212)(H,206,213)(H,210,265)(H,214,293)(H,215,254)(H,216,268)(H,217,267)(H,218,270)(H,219,278)(H,220,274)(H,221,279)(H,222,291)(H,223,280)(H,224,292)(H,225,294)(H,226,296)(H,227,286)(H,228,269)(H,229,272)(H,230,282)(H,231,283)(H,232,287)(H,233,273)(H,234,266)(H,235,275)(H,236,281)(H,237,284)(H,238,285)(H,239,271)(H,240,295)(H,241,264)(H,242,288)(H,243,276)(H,244,289)(H,245,290)(H,246,277)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H4,200,201,207)(H4,202,203,208)/b109-71-/t99-,100+,101-,102-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,149-,150-,151-,152-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP production


J Med Chem 61: 5822-5880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01788
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50269978
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)


Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V
More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(Homo sapiens (Human))
BDBM50517918
PNG
(CHEMBL276472)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](\C=C(/Cl)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C190H306ClN57O50S2/c1-25-101(20)154(248-169(279)122(52-57-149(261)262)224-183(293)139(87-249)243-156(266)110(97(12)13)77-111(191)102(21)195)188(298)228-119(49-54-142(197)252)164(274)231-127(69-94(6)7)172(282)225-124(59-66-300-24)167(277)237-133(75-107-84-207-90-214-107)176(286)239-135(78-143(198)253)178(288)229-125(67-92(2)3)157(267)212-86-146(256)217-113(43-31-34-60-192)158(268)236-132(74-106-83-206-89-213-106)175(285)233-129(71-96(10)11)173(283)238-137(80-145(200)255)180(290)244-140(88-250)184(294)226-123(58-65-299-23)166(276)222-120(50-55-147(257)258)162(272)220-117(47-38-64-210-190(204)205)168(278)245-152(99(16)17)186(296)227-121(51-56-148(259)260)165(275)235-131(73-105-82-211-112-42-30-29-41-109(105)112)174(284)232-128(70-95(8)9)170(280)221-116(46-37-63-209-189(202)203)160(270)218-114(44-32-35-61-193)159(269)219-115(45-33-36-62-194)161(271)230-126(68-93(4)5)171(281)223-118(48-53-141(196)251)163(273)241-138(81-150(263)264)182(292)247-153(100(18)19)187(297)242-134(76-108-85-208-91-215-108)177(287)240-136(79-144(199)254)179(289)234-130(72-104-39-27-26-28-40-104)181(291)246-151(98(14)15)185(295)216-103(22)155(201)265/h26-30,39-42,77,82-85,89-103,110,113-140,151-154,211,249-250H,25,31-38,43-76,78-81,86-88,192-195H2,1-24H3,(H2,196,251)(H2,197,252)(H2,198,253)(H2,199,254)(H2,200,255)(H2,201,265)(H,206,213)(H,207,214)(H,208,215)(H,212,267)(H,216,295)(H,217,256)(H,218,270)(H,219,269)(H,220,272)(H,221,280)(H,222,276)(H,223,281)(H,224,293)(H,225,282)(H,226,294)(H,227,296)(H,228,298)(H,229,288)(H,230,271)(H,231,274)(H,232,284)(H,233,285)(H,234,289)(H,235,275)(H,236,268)(H,237,277)(H,238,283)(H,239,286)(H,240,287)(H,241,273)(H,242,297)(H,243,266)(H,244,290)(H,245,278)(H,246,291)(H,247,292)(H,248,279)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H4,202,203,209)(H4,204,205,210)/b111-77-/t101-,102-,103-,110-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,151-,152-,153-,154-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 7.90n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP production


J Med Chem 61: 5822-5880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01788
More data for this
Ligand-Target Pair
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