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Found 426 hits Enz. Inhib. hit(s) with Target = 'Period circadian protein homolog 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410826
PNG
(US10383880, Example 38)
Show SMILES O[C@H](CN1CCCCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H22N2O3S/c22-15(13-20-11-5-6-12-25(20,23)24)14-21-18-9-3-1-7-16(18)17-8-2-4-10-19(17)21/h1-4,7-10,15,22H,5-6,11-14H2/t15-/m1/s1
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n/an/an/an/a 11n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410874
PNG
(US10383880, Example 87)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H18F2N2O3S/c19-12-2-4-17-15(8-12)16-9-13(20)3-5-18(16)22(17)11-14(23)10-21-6-1-7-26(21,24)25/h2-5,8-9,14,23H,1,6-7,10-11H2
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n/an/an/an/a 20n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410827
PNG
(US10383880, Example 39)
Show SMILES O[C@H](CN1CCCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C18H20N2O3S/c21-14(12-19-10-5-11-24(19,22)23)13-20-17-8-3-1-6-15(17)16-7-2-4-9-18(16)20/h1-4,6-9,14,21H,5,10-13H2/t14-/m1/s1
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n/an/an/an/a 21n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410907
PNG
(US10383880, Example 120)
Show SMILES OC(CN1CCC(F)S1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C18H19FN2O3S/c19-18-9-10-20(25(18,23)24)11-13(22)12-21-16-7-3-1-5-14(16)15-6-2-4-8-17(15)21/h1-8,13,18,22H,9-12H2
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n/an/an/an/a 23n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410959
PNG
(US10383880, Example 171)
Show SMILES OC(CN1CCCNS1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H19F2N3O3S/c19-12-2-4-17-15(8-12)16-9-13(20)3-5-18(16)23(17)11-14(24)10-22-7-1-6-21-27(22,25)26/h2-5,8-9,14,21,24H,1,6-7,10-11H2
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n/an/an/an/a 25n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410931
PNG
(US10383880, Example 143)
Show SMILES CC1(CCCC1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C22H28N2O3S/c1-22(13-7-8-14-22)24(28(2,26)27)16-17(25)15-23-20-11-5-3-9-18(20)19-10-4-6-12-21(19)23/h3-6,9-12,17,25H,7-8,13-16H2,1-2H3
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n/an/an/an/a 28n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140888
PNG
(CHEMBL3753839 | US10383880, Example 20)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H20N2O3S/c21-14(12-19-10-5-11-24(19,22)23)13-20-17-8-3-1-6-15(17)16-7-2-4-9-18(16)20/h1-4,6-9,14,21H,5,10-13H2
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n/an/an/an/a 29n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410822
PNG
(US10383880, Example 34)
Show SMILES OC(CN1Cc2ccccc2S1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C22H20N2O3S/c25-17(14-23-13-16-7-1-6-12-22(16)28(23,26)27)15-24-20-10-4-2-8-18(20)19-9-3-5-11-21(19)24/h1-12,17,25H,13-15H2
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n/an/an/an/a 31n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410883
PNG
(US10383880, Example 100 | US10383880, Example 96)
Show SMILES OC(CN1CCCCS1(=O)=O)Cn1c2cc(F)ccc2c2c(F)cccc12
Show InChI InChI=1S/C19H20F2N2O3S/c20-13-6-7-15-18(10-13)23(17-5-3-4-16(21)19(15)17)12-14(24)11-22-8-1-2-9-27(22,25)26/h3-7,10,14,24H,1-2,8-9,11-12H2
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n/an/an/an/a 32n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140893
PNG
(CHEMBL3753932 | US10383880, Example 123)
Show SMILES OC(CN1CCCNS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H21N3O3S/c22-14(12-20-11-5-10-19-25(20,23)24)13-21-17-8-3-1-6-15(17)16-7-2-4-9-18(16)21/h1-4,6-9,14,19,22H,5,10-13H2
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n/an/an/an/a 33n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410825
PNG
(US10383880, Example 37)
Show SMILES OC(CN1c2ccccc2CCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C23H22N2O3S/c26-18(16-25-21-10-4-1-7-17(21)13-14-29(25,27)28)15-24-22-11-5-2-8-19(22)20-9-3-6-12-23(20)24/h1-12,18,26H,13-16H2
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n/an/an/an/a 34n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410963
PNG
(US10383880, Example 175)
Show SMILES OC(CN1CCNCS1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H19F2N3O3S/c19-12-1-3-17-15(7-12)16-8-13(20)2-4-18(16)23(17)10-14(24)9-22-6-5-21-11-27(22,25)26/h1-4,7-8,14,21,24H,5-6,9-11H2
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a 35n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140922
PNG
(CHEMBL3752819 | US10383880, Example 57)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCC1
Show InChI InChI=1/C20H24N2O3S/c1-26(24,25)22(15-7-6-8-15)14-16(23)13-21-19-11-4-2-9-17(19)18-10-3-5-12-20(18)21/h2-5,9-12,15-16,23H,6-8,13-14H2,1H3
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n/an/an/an/a 35n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140889
PNG
(CHEMBL3752502 | US10383880, Example 33)
Show SMILES OC(CN1CCCCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C19H22N2O3S/c22-15(13-20-11-5-6-12-25(20,23)24)14-21-18-9-3-1-7-16(18)17-8-2-4-10-19(17)21/h1-4,7-10,15,22H,5-6,11-14H2
PDB

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n/an/an/an/a 35n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410906
PNG
(US10383880, Example 119)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)C1CCC1
Show InChI InChI=1S/C20H22F2N2O3S/c1-28(26,27)24(15-3-2-4-15)12-16(25)11-23-19-7-5-13(21)9-17(19)18-10-14(22)6-8-20(18)23/h5-10,15-16,25H,2-4,11-12H2,1H3
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n/an/an/an/a 37n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410879
PNG
(US10383880, Example 92)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2cc(F)ccc2c2ccc(F)cc12
Show InChI InChI=1S/C18H18F2N2O3S/c19-12-2-4-15-16-5-3-13(20)9-18(16)22(17(15)8-12)11-14(23)10-21-6-1-7-26(21,24)25/h2-5,8-9,14,23H,1,6-7,10-11H2
PDB

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n/an/an/an/a 40n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410925
PNG
(US10383880, Example 138)
Show SMILES CC1(CCC1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H26N2O3S/c1-21(12-7-13-21)23(27(2,25)26)15-16(24)14-22-19-10-5-3-8-17(19)18-9-4-6-11-20(18)22/h3-6,8-11,16,24H,7,12-15H2,1-2H3
PDB

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n/an/an/an/a 41n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140891
PNG
(CHEMBL3753487)
Show SMILES OC(CN1CCNS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C17H19N3O3S/c21-13(11-19-10-9-18-24(19,22)23)12-20-16-7-3-1-5-14(16)15-6-2-4-8-17(15)20/h1-8,13,18,21H,9-12H2
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PubMed
n/an/an/an/a 42n/an/an/an/a



Reset Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.102
BindingDB Entry DOI: 10.7270/Q2DR2XCS
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM411033
PNG
(US10383880, Example 243)
Show SMILES CC(C)(C(O)Cn1c2ccccc2c2ccccc12)N1CCCS1(=O)=O
Show InChI InChI=1S/C20H24N2O3S/c1-20(2,22-12-7-13-26(22,24)25)19(23)14-21-17-10-5-3-8-15(17)16-9-4-6-11-18(16)21/h3-6,8-11,19,23H,7,12-14H2,1-2H3
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US Patent
n/an/an/an/a 42n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410899
PNG
(US10383880, Example 112)
Show SMILES COC1CCS(=O)(=O)N(CC(O)Cn2c3ccccc3c3ccccc23)C1
Show InChI InChI=1S/C20H24N2O4S/c1-26-16-10-11-27(24,25)21(14-16)12-15(23)13-22-19-8-4-2-6-17(19)18-7-3-5-9-20(18)22/h2-9,15-16,23H,10-14H2,1H3
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n/an/an/an/a 44n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410973
PNG
(US10383880, Example 185)
Show SMILES OC(CN1CCC(F)(F)S1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H16F4N2O3S/c19-11-1-3-16-14(7-11)15-8-12(20)2-4-17(15)24(16)10-13(25)9-23-6-5-18(21,22)28(23,26)27/h1-4,7-8,13,25H,5-6,9-10H2
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n/an/an/an/a 45n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410873
PNG
(US10383880, Example 86)
Show SMILES OC(CN1CCCCS1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C19H20F2N2O3S/c20-13-3-5-18-16(9-13)17-10-14(21)4-6-19(17)23(18)12-15(24)11-22-7-1-2-8-27(22,25)26/h3-6,9-10,15,24H,1-2,7-8,11-12H2
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n/an/an/an/a 46n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410888
PNG
(US10383880, Example 101)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2ccc(F)cc2c2ccc(F)cc12
Show InChI InChI=1S/C18H18F2N2O3S/c19-12-3-5-17-16(8-12)15-4-2-13(20)9-18(15)22(17)11-14(23)10-21-6-1-7-26(21,24)25/h2-5,8-9,14,23H,1,6-7,10-11H2
PDB

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n/an/an/an/a 50n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410908
PNG
(US10383880, Example 121)
Show SMILES OC(CN1CCCC(F)S1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1S/C19H21FN2O3S/c20-19-10-5-11-21(26(19,24)25)12-14(23)13-22-17-8-3-1-6-15(17)16-7-2-4-9-18(16)22/h1-4,6-9,14,19,23H,5,10-13H2
PDB

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n/an/an/an/a 51n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356927
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CCC1CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C(=O)C1
Show InChI InChI=1/C21H22F2N2O2/c1-2-13-7-21(27)24(10-13)11-16(26)12-25-19-5-3-14(22)8-17(19)18-9-15(23)4-6-20(18)25/h3-6,8-9,13,16,26H,2,7,10-12H2,1H3
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US Patent
n/an/an/an/a 52n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410971
PNG
(US10383880, Example 183)
Show SMILES OC(CN1CCC(F)S1(=O)=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1S/C18H17F3N2O3S/c19-11-1-3-16-14(7-11)15-8-12(20)2-4-17(15)23(16)10-13(24)9-22-6-5-18(21)27(22,25)26/h1-4,7-8,13,18,24H,5-6,9-10H2
PDB

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n/an/an/an/a 53n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356720
PNG
((1R,4S)-2-((R)-3- (3,6-difluoro-9H- carbazol-9-yl)...)
Show SMILES O[C@@H](CN1[C@@H]2CC[C@@H](C2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1/C21H20F2N2O2/c22-13-2-5-19-17(8-13)18-9-14(23)3-6-20(18)25(19)11-16(26)10-24-15-4-1-12(7-15)21(24)27/h2-3,5-6,8-9,12,15-16,26H,1,4,7,10-11H2/t12-,15+,16-/s2
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n/an/an/an/a 54n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM411034
PNG
(US10383880, Example 244)
Show SMILES CC(C)(C(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)N1CCCS1(=O)=O
Show InChI InChI=1S/C20H22F2N2O3S/c1-20(2,24-8-3-9-28(24,26)27)19(25)12-23-17-6-4-13(21)10-15(17)16-11-14(22)5-7-18(16)23/h4-7,10-11,19,25H,3,8-9,12H2,1-2H3
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n/an/an/an/a 57n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM411014
PNG
(US10383880, Example 224)
Show SMILES CC(C)N1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S(=O)(=O)C1
Show InChI InChI=1S/C21H25F2N3O3S/c1-14(2)24-7-8-25(30(28,29)13-24)11-17(27)12-26-20-5-3-15(22)9-18(20)19-10-16(23)4-6-21(19)26/h3-6,9-10,14,17,27H,7-8,11-13H2,1-2H3
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n/an/an/an/a 59n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356634
PNG
(1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- fluo...)
Show SMILES OC(CN1CCCC(F)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C20H21FN2O2/c21-17-8-5-11-22(20(17)25)12-14(24)13-23-18-9-3-1-6-15(18)16-7-2-4-10-19(16)23/h1-4,6-7,9-10,14,17,24H,5,8,11-13H2
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n/an/an/an/a 61n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140890
PNG
(CHEMBL3754594)
Show SMILES OC(CN1CCOCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H20N2O4S/c21-14(11-19-9-10-24-13-25(19,22)23)12-20-17-7-3-1-5-15(17)16-6-2-4-8-18(16)20/h1-8,14,21H,9-13H2
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n/an/an/an/a 73n/an/an/an/a



Reset Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.102
BindingDB Entry DOI: 10.7270/Q2DR2XCS
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410966
PNG
(US10383880, Example 178)
Show SMILES CC1(C)CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S1(=O)=O
Show InChI InChI=1S/C20H22F2N2O3S/c1-20(2)7-8-23(28(20,26)27)11-15(25)12-24-18-5-3-13(21)9-16(18)17-10-14(22)4-6-19(17)24/h3-6,9-10,15,25H,7-8,11-12H2,1-2H3
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n/an/an/an/a 73n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410924
PNG
(US10383880, Example 137)
Show SMILES CC1(CC1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H24N2O3S/c1-20(11-12-20)22(26(2,24)25)14-15(23)13-21-18-9-5-3-7-16(18)17-8-4-6-10-19(17)21/h3-10,15,23H,11-14H2,1-2H3
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n/an/an/an/a 76n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410984
PNG
(US10383880, Example 194)
Show SMILES CC1CN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S(=O)(=O)C1
Show InChI InChI=1S/C19H20F2N2O3S/c1-12-8-22(27(25,26)11-12)9-15(24)10-23-18-4-2-13(20)6-16(18)17-7-14(21)3-5-19(17)23/h2-7,12,15,24H,8-11H2,1H3
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n/an/an/an/a 78n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356696
PNG
(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Show SMILES CC(C)C1CCCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1=O
Show InChI InChI=1/C23H26F2N2O2/c1-14(2)18-4-3-9-26(23(18)29)12-17(28)13-27-21-7-5-15(24)10-19(21)20-11-16(25)6-8-22(20)27/h5-8,10-11,14,17-18,28H,3-4,9,12-13H2,1-2H3
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n/an/an/an/a 79n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410918
PNG
(US10383880, Example 131)
Show SMILES CC1CC(C1)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H26N2O3S/c1-15-11-16(12-15)23(27(2,25)26)14-17(24)13-22-20-9-5-3-7-18(20)19-8-4-6-10-21(19)22/h3-10,15-17,24H,11-14H2,1-2H3
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n/an/an/an/a 79n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410962
PNG
(US10383880, Example 174)
Show SMILES CN1CCN(CC(C)(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S(=O)(=O)C1
Show InChI InChI=1S/C20H23F2N3O3S/c1-20(26,11-24-8-7-23(2)13-29(24,27)28)12-25-18-5-3-14(21)9-16(18)17-10-15(22)4-6-19(17)25/h3-6,9-10,26H,7-8,11-13H2,1-2H3
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n/an/an/an/a 80n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410905
PNG
(US10383880, Example 118)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)C1CC1
Show InChI InChI=1S/C19H20F2N2O3S/c1-27(25,26)23(14-4-5-14)11-15(24)10-22-18-6-2-12(20)8-16(18)17-9-13(21)3-7-19(17)22/h2-3,6-9,14-15,24H,4-5,10-11H2,1H3
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n/an/an/an/a 81n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410974
PNG
(US10383880, Example 186)
Show SMILES CC1(CCC1)N(CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H24F2N2O3S/c1-21(8-3-9-21)25(29(2,27)28)13-16(26)12-24-19-6-4-14(22)10-17(19)18-11-15(23)5-7-20(18)24/h4-7,10-11,16,26H,3,8-9,12-13H2,1-2H3
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n/an/an/an/a 83n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410898
PNG
(US10383880, Example 111)
Show SMILES CC1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)S1(=O)=O
Show InChI InChI=1S/C20H24N2O3S/c1-15-7-6-12-21(26(15,24)25)13-16(23)14-22-19-10-4-2-8-17(19)18-9-3-5-11-20(18)22/h2-5,8-11,15-16,23H,6-7,12-14H2,1H3
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n/an/an/an/a 84n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410961
PNG
(US10383880, Example 173)
Show SMILES CN1CCN(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)S(=O)(=O)C1
Show InChI InChI=1S/C19H21F2N3O3S/c1-22-6-7-23(28(26,27)12-22)10-15(25)11-24-18-4-2-13(20)8-16(18)17-9-14(21)3-5-19(17)24/h2-5,8-9,15,25H,6-7,10-12H2,1H3
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n/an/an/an/a 86n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356724
PNG
((1R,4S)-2-((R)-3- (9H-carbazol-9-yl)- 2-hydroxypro...)
Show SMILES O[C@@H](CN1[C@@H]2CC[C@@H](C2)C1=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C21H22N2O2/c24-16(12-22-15-10-9-14(11-15)21(22)25)13-23-19-7-3-1-5-17(19)18-6-2-4-8-20(18)23/h1-8,14-16,24H,9-13H2/t14-,15+,16-/s2
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n/an/an/an/a 89n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140765
PNG
(CHEMBL1446115 | US10383880, Example 23)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccccc1
Show InChI InChI=1/C22H22N2O3S/c1-28(26,27)24(17-9-3-2-4-10-17)16-18(25)15-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h2-14,18,25H,15-16H2,1H3
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n/an/an/an/a 90n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410953
PNG
(US10383880, Example 165)
Show SMILES CC(C)N(CC(O)Cn1c2ccc(F)cc2c2ccc(F)cc12)S(C)(=O)=O
Show InChI InChI=1S/C19H22F2N2O3S/c1-12(2)23(27(3,25)26)11-15(24)10-22-18-7-5-13(20)8-17(18)16-6-4-14(21)9-19(16)22/h4-9,12,15,24H,10-11H2,1-3H3
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n/an/an/an/a 95n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356922
PNG
((R)-1-((R)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@@H]1CCC(=O)N1C[C@H](O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C20H22N2O2/c1-14-10-11-20(24)21(14)12-15(23)13-22-18-8-4-2-6-16(18)17-7-3-5-9-19(17)22/h2-9,14-15,23H,10-13H2,1H3/t14-,15+/s2
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n/an/an/an/a 95n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140907
PNG
(CHEMBL1487843 | US10383880, Example 32)
Show SMILES CN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C17H20N2O3S/c1-18(23(2,21)22)11-13(20)12-19-16-9-5-3-7-14(16)15-8-4-6-10-17(15)19/h3-10,13,20H,11-12H2,1-2H3
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n/an/an/an/a 100n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140920
PNG
(CHEMBL3752323 | US10383880, Example 49)
Show SMILES CC(C)CN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C20H26N2O3S/c1-15(2)12-21(26(3,24)25)13-16(23)14-22-19-10-6-4-8-17(19)18-9-5-7-11-20(18)22/h4-11,15-16,23H,12-14H2,1-3H3
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n/an/an/an/a 100n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM50140919
PNG
(CHEMBL3753078 | US10383880, Example 46)
Show SMILES CC(C)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C19H24N2O3S/c1-14(2)21(25(3,23)24)13-15(22)12-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,14-15,22H,12-13H2,1-3H3
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n/an/an/an/a 100n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM410923
PNG
(US10383880, Example 136)
Show SMILES CC1CCCC1N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C22H28N2O3S/c1-16-8-7-13-20(16)24(28(2,26)27)15-17(25)14-23-21-11-5-3-9-18(21)19-10-4-6-12-22(19)23/h3-6,9-12,16-17,20,25H,7-8,13-15H2,1-2H3
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n/an/an/an/a 113n/an/an/an/a



Synchronicity

US Patent


Assay Description
Per2 Assay for Evaluating the Potency of Test Compounds.


US Patent US10383880 (2019)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356717
PNG
(US10214507, Compound 104)
Show SMILES O[C@@H](CN1[C@H]2CC[C@H](C2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Show InChI InChI=1/C21H20F2N2O2/c22-13-2-5-19-17(8-13)18-9-14(23)3-6-20(18)25(19)11-16(26)10-24-15-4-1-12(7-15)21(24)27/h2-3,5-6,8-9,12,15-16,26H,1,4,7,10-11H2/t12-,15+,16+/s2
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n/an/an/an/a 115n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


Article DOI: 10.1021/jm060435i
More data for this
Ligand-Target Pair
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