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Compile Data Set for Download or QSAR

Found 2280 hits Enz. Inhib. hit(s) with Target = 'Peroxisome proliferator-activated receptor delta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50213701
PNG
((R)-2-(2-methyl-4-(2-((4-(trifluoromethyl)phenoxy)...)
Show SMILES CC[C@H](COc1ccc(cc1)C(F)(F)F)CSc1ccc(OCC(O)=O)c(C)c1
Show InChI InChI=1S/C21H23F3O4S/c1-3-15(11-27-17-6-4-16(5-7-17)21(22,23)24)13-29-18-8-9-19(14(2)10-18)28-12-20(25)26/h4-10,15H,3,11-13H2,1-2H3,(H,25,26)/t15-/m1/s1
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n/an/an/an/a 0.0300n/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta receptor by cell based transactivation assay


Bioorg Med Chem Lett 17: 3855-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.007
BindingDB Entry DOI: 10.7270/Q28W3D05
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50213715
PNG
(2-(2-methyl-4-(2-((4-(trifluoromethyl)phenoxy)meth...)
Show SMILES CCC(COc1ccc(cc1)C(F)(F)F)CSc1ccc(OCC(O)=O)c(C)c1
Show InChI InChI=1S/C21H23F3O4S/c1-3-15(11-27-17-6-4-16(5-7-17)21(22,23)24)13-29-18-8-9-19(14(2)10-18)28-12-20(25)26/h4-10,15H,3,11-13H2,1-2H3,(H,25,26)
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n/an/an/an/a 0.0600n/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta receptor by cell based transactivation assay


Bioorg Med Chem Lett 17: 3855-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.007
BindingDB Entry DOI: 10.7270/Q28W3D05
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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n/an/an/an/a 0.180n/an/an/an/a



Phenex Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Agonist activity at human PPARbeta expressed in HEK293 cells by luciferase reporter gene assay


Bioorg Med Chem Lett 24: 5265-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.09.053
BindingDB Entry DOI: 10.7270/Q2S46TKZ
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50334843
PNG
((R)-2-(4-((3-(2,4-dichlorophenylcarbamoyl)-3,4-dih...)
Show SMILES Cc1cc(CN2Cc3ccccc3C[C@@H]2C(=O)Nc2ccc(Cl)cc2Cl)ccc1OCC(O)=O
Show InChI InChI=1S/C26H24Cl2N2O4/c1-16-10-17(6-9-24(16)34-15-25(31)32)13-30-14-19-5-3-2-4-18(19)11-23(30)26(33)29-22-8-7-20(27)12-21(22)28/h2-10,12,23H,11,13-15H2,1H3,(H,29,33)(H,31,32)/t23-/m1/s1
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n/an/an/an/a 0.5n/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Agonist activity at GAL4-fused human PPARdelta DNA binding domain expressed in HEK293 cells by luciferase reporter gene assay


Bioorg Med Chem Lett 21: 492-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.117
BindingDB Entry DOI: 10.7270/Q2ST7Q3Q
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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University of Oslo

Curated by ChEMBL


Assay Description
Agonist activity at pSG5-Gal4-tagged human PPAR-beta/delta ligand binding domain expressed in COS1 cells assessed as receptor activation incubated fo...


Eur J Med Chem 94: 229-36 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.006
BindingDB Entry DOI: 10.7270/Q25H7HZR
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21787
PNG
(2-[(1S)-5-{3-[2-methoxy-4-(1,3-thiazol-2-yl)phenox...)
Show SMILES COc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1nccs1
Show InChI InChI=1S/C24H25NO5S/c1-28-22-14-18(24-25-9-12-31-24)5-8-21(22)30-11-2-10-29-19-6-7-20-16(13-19)3-4-17(20)15-23(26)27/h5-9,12-14,17H,2-4,10-11,15H2,1H3,(H,26,27)/t17-/m0/s1
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n/an/an/an/a 0.580n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50214207
PNG
((2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl...)
Show SMILES CCCCOc1ccc(C[C@H](CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C24H27F4NO4/c1-3-5-10-33-21-9-6-15(11-16(4-2)23(31)32)12-17(21)14-29-22(30)19-8-7-18(13-20(19)25)24(26,27)28/h6-9,12-13,16H,3-5,10-11,14H2,1-2H3,(H,29,30)(H,31,32)/t16-/m0/s1
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n/an/an/an/a 0.720n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at PPARdelta receptor expressed in HEK293 cells cotransfected with GAL4 by transactivation assay


Bioorg Med Chem Lett 19: 6595-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.021
BindingDB Entry DOI: 10.7270/Q2736R23
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50214207
PNG
((2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl...)
Show SMILES CCCCOc1ccc(C[C@H](CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C24H27F4NO4/c1-3-5-10-33-21-9-6-15(11-16(4-2)23(31)32)12-17(21)14-29-22(30)19-8-7-18(13-20(19)25)24(26,27)28/h6-9,12-13,16H,3-5,10-11,14H2,1-2H3,(H,29,30)(H,31,32)/t16-/m0/s1
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n/an/an/an/a 0.720n/an/an/an/a



Okayama University

Curated by ChEMBL


Assay Description
Transactivation of Gal4-fused human PPARdelta expressed in HEK293 cells after 16 to 20 hrs by luciferase reporter gene assay


J Med Chem 54: 331-41 (2011)


Article DOI: 10.1021/jm101233f
BindingDB Entry DOI: 10.7270/Q2TM7C3T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50332462
PNG
(2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phe...)
Show SMILES Cc1nc(sc1C[Se]c1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3SSe/c1-12-9-16(7-8-17(12)28-10-19(26)27)30-11-18-13(2)25-20(29-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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n/an/an/an/a 0.900n/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Agonist activity at human PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 7239-42 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.103
BindingDB Entry DOI: 10.7270/Q2SN0975
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50214207
PNG
((2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl...)
Show SMILES CCCCOc1ccc(C[C@H](CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C24H27F4NO4/c1-3-5-10-33-21-9-6-15(11-16(4-2)23(31)32)12-17(21)14-29-22(30)19-8-7-18(13-20(19)25)24(26,27)28/h6-9,12-13,16H,3-5,10-11,14H2,1-2H3,(H,29,30)(H,31,32)/t16-/m0/s1
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n/an/an/an/a 0.910n/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Effect on PPARdelta transactivation activity in HEK293 cells


Bioorg Med Chem 15: 5177-90 (2007)


Article DOI: 10.1016/j.bmc.2007.05.023
BindingDB Entry DOI: 10.7270/Q2QZ29P7
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21785
PNG
(2-[(1S)-5-(3-{4-[5-(trifluoromethyl)pyridin-2-yl]p...)
Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-c3ccc(cn3)C(F)(F)F)ccc12
Show InChI InChI=1S/C26H24F3NO4/c27-26(28,29)20-6-11-24(30-16-20)17-4-7-21(8-5-17)33-12-1-13-34-22-9-10-23-18(14-22)2-3-19(23)15-25(31)32/h4-11,14,16,19H,1-3,12-13,15H2,(H,31,32)/t19-/m0/s1
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n/an/an/an/a 0.950n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50332466
PNG
(2-(4-((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-me...)
Show SMILES Cc1nc(sc1C[Se]c1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C21H17F4NO3SSe/c1-11-7-14(4-6-17(11)29-9-19(27)28)31-10-18-12(2)26-20(30-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
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Seoul National University

Curated by ChEMBL


Assay Description
Agonist activity at human PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 7239-42 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.103
BindingDB Entry DOI: 10.7270/Q2SN0975
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50312480
PNG
(2-(4-((4-(2-Isopropoxypyrimidin-5-yl)-5-(4-(triflu...)
Show SMILES CC(C)Oc1ncc(cn1)-c1nc(COc2ccc(OCC(O)=O)c(C)c2)oc1-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C27H24F3N3O7/c1-15(2)38-26-31-11-18(12-32-26)24-25(17-4-6-19(7-5-17)40-27(28,29)30)39-22(33-24)13-36-20-8-9-21(16(3)10-20)37-14-23(34)35/h4-12,15H,13-14H2,1-3H3,(H,34,35)
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The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50172358
PNG
(Biphenyl-4-carboxylic acid (2,2-dimethyl-2H-chrome...)
Show SMILES CC(C)N(Cc1cccc2C=CC(C)(C)Oc12)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H29NO2/c1-20(2)29(19-25-12-8-11-23-17-18-28(3,4)31-26(23)25)27(30)24-15-13-22(14-16-24)21-9-6-5-7-10-21/h5-18,20H,19H2,1-4H3
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Effective concentration against PPAR delta receptor


J Med Chem 48: 5613-38 (2005)


Article DOI: 10.1021/jm050524f
BindingDB Entry DOI: 10.7270/Q2V988V1
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50312419
PNG
(2-(4-((4-(4-(N-Isopropyl-N-methyl)benzamide)-5-(4-...)
Show SMILES CC(C)N(C)C(=O)c1ccc(cc1)-c1nc(COc2ccc(OCC(O)=O)c(C)c2)oc1-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H29F3N2O7/c1-18(2)36(4)30(39)22-7-5-20(6-8-22)28-29(21-9-11-23(12-10-21)43-31(32,33)34)42-26(35-28)16-40-24-13-14-25(19(3)15-24)41-17-27(37)38/h5-15,18H,16-17H2,1-4H3,(H,37,38)
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The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50312481
PNG
(2-(4-((4-(2-Morpholinopyrimidin-5-yl)-5-(4-(triflu...)
Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2cnc(nc2)N2CCOCC2)ccc1OCC(O)=O
Show InChI InChI=1S/C28H25F3N4O7/c1-17-12-21(6-7-22(17)40-16-24(36)37)39-15-23-34-25(19-13-32-27(33-14-19)35-8-10-38-11-9-35)26(41-23)18-2-4-20(5-3-18)42-28(29,30)31/h2-7,12-14H,8-11,15-16H2,1H3,(H,36,37)
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The Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...


J Med Chem 53: 77-105 (2010)


Article DOI: 10.1021/jm9007399
BindingDB Entry DOI: 10.7270/Q28052RP
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50227763
PNG
((R)-3-(4-(3-(1-(5-chloro-1,3-dimethyl-1H-indole-2-...)
Show SMILES CCc1cc(Oc2cc(F)cc(c2)[C@@H](C)NC(=O)c2c(C)c3cc(Cl)ccc3n2C)ccc1CCC(O)=O
Show InChI InChI=1S/C30H30ClFN2O4/c1-5-19-13-24(9-6-20(19)7-11-28(35)36)38-25-14-21(12-23(32)16-25)18(3)33-30(37)29-17(2)26-15-22(31)8-10-27(26)34(29)4/h6,8-10,12-16,18H,5,7,11H2,1-4H3,(H,33,37)(H,35,36)/t18-/m1/s1
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta expressed in CV1 cells by receptor transactivation assay


Bioorg Med Chem Lett 17: 6744-9 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.047
BindingDB Entry DOI: 10.7270/Q2VT1RTW
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50160404
PNG
(CHEMBL3786533)
Show SMILES Cc1cc(SCc2cnc(s2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H15F4NO3S2/c1-11-6-13(3-5-17(11)28-9-18(26)27)29-10-14-8-25-19(30-14)12-2-4-15(16(21)7-12)20(22,23)24/h2-8H,9-10H2,1H3,(H,26,27)
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Texas Tech University Health Sciences Center

Curated by ChEMBL


Assay Description
Agonist activity at PPAR delta (unknown origin) transfected in HEK293 cells after 24 hrs by dual-luciferase reporter gene assay


Bioorg Med Chem Lett 26: 1889-93 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.028
BindingDB Entry DOI: 10.7270/Q2NK3GZV
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50160404
PNG
(CHEMBL3786533)
Show SMILES Cc1cc(SCc2cnc(s2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H15F4NO3S2/c1-11-6-13(3-5-17(11)28-9-18(26)27)29-10-14-8-25-19(30-14)12-2-4-15(16(21)7-12)20(22,23)24/h2-8H,9-10H2,1H3,(H,26,27)
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Texas Tech University Health Sciences Center

Curated by ChEMBL


Assay Description
Agonist activity at human PPAR delta by cell based reporter assay


Bioorg Med Chem Lett 26: 1889-93 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.028
BindingDB Entry DOI: 10.7270/Q2NK3GZV
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM232290
PNG
(US9346770, 3)
Show SMILES CCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)C(F)(F)F)ccc1CCC(O)=O
Show InChI InChI=1S/C24H24F3NO4/c1-3-16-14-20(10-6-17(16)7-11-22(29)30)31-13-12-21-15(2)32-23(28-21)18-4-8-19(9-5-18)24(25,26)27/h4-6,8-10,14H,3,7,11-13H2,1-2H3,(H,29,30)
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n/an/an/an/a<1n/an/an/an/a



ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...


US Patent US9346770 (2016)


BindingDB Entry DOI: 10.7270/Q21Z438X
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM232289
PNG
(US9346770, 2)
Show SMILES CCc1cc(OCCc2coc(n2)-c2ccc(cc2)C(F)(F)F)ccc1CCC(O)=O
Show InChI InChI=1S/C23H22F3NO4/c1-2-15-13-20(9-5-16(15)6-10-21(28)29)30-12-11-19-14-31-22(27-19)17-3-7-18(8-4-17)23(24,25)26/h3-5,7-9,13-14H,2,6,10-12H2,1H3,(H,28,29)
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ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...


US Patent US9346770 (2016)


BindingDB Entry DOI: 10.7270/Q21Z438X
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50384971
PNG
(CHEMBL2035069)
Show SMILES CCCC(Sc1ccc(OCC(O)=O)c(C)c1)c1sc(nc1C)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H24F3NO3S2/c1-4-5-20(32-18-10-11-19(14(2)12-18)31-13-21(29)30)22-15(3)28-23(33-22)16-6-8-17(9-7-16)24(25,26)27/h6-12,20H,4-5,13H2,1-3H3,(H,29,30)
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Seoul National University

Curated by ChEMBL


Assay Description
Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


Eur J Med Chem 53: 190-202 (2012)


Article DOI: 10.1016/j.ejmech.2012.03.055
BindingDB Entry DOI: 10.7270/Q2JW8FX2
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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n/an/an/an/a 1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Maximum transcriptional activation of human PPAR delta receptor


Bioorg Med Chem Lett 13: 1517-21 (2003)


Article DOI: 10.1016/s0960-894x(03)00207-5
BindingDB Entry DOI: 10.7270/Q2VQ322G
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50127222
PNG
(CHEMBL38508 | {4-[2-(3-Fluoro-4-trifluoromethyl-ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
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n/an/an/an/a 1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Maximum transcriptional activation of human PPAR delta receptor


Bioorg Med Chem Lett 13: 1517-21 (2003)


Article DOI: 10.1016/s0960-894x(03)00207-5
BindingDB Entry DOI: 10.7270/Q2VQ322G
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50194628
PNG
((R)-3-{2-methyl-4-[3-(2-phenoxy-4-trifluoromethyl-...)
Show SMILES C[C@H](CCOc1ccc(CCC(O)=O)c(C)c1)Oc1ccc(cc1Oc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3O5/c1-18-16-23(11-8-20(18)9-13-26(31)32)33-15-14-19(2)34-24-12-10-21(27(28,29)30)17-25(24)35-22-6-4-3-5-7-22/h3-8,10-12,16-17,19H,9,13-15H2,1-2H3,(H,31,32)/t19-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Transactivation of human PPARdelta in CV1 cells by luciferase reporter gene assay


J Med Chem 49: 5649-52 (2006)


Article DOI: 10.1021/jm060617c
BindingDB Entry DOI: 10.7270/Q2K073WF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50194627
PNG
((R)-3-(4-(3-(2-benzoyl-4-ethylphenoxy)butoxy)-2-me...)
Show SMILES CCc1ccc(O[C@H](C)CCOc2ccc(CCC(O)=O)c(C)c2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H32O5/c1-4-22-10-14-27(26(19-22)29(32)24-8-6-5-7-9-24)34-21(3)16-17-33-25-13-11-23(20(2)18-25)12-15-28(30)31/h5-11,13-14,18-19,21H,4,12,15-17H2,1-3H3,(H,30,31)/t21-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human Gal4-PPARdelta expressed in CV1 cells by transactivation assay


Bioorg Med Chem Lett 17: 1052-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.029
BindingDB Entry DOI: 10.7270/Q2BP02F8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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n/an/an/an/a 1n/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells


Bioorg Med Chem Lett 16: 4528-32 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.028
BindingDB Entry DOI: 10.7270/Q28915HC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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Johnson & Johnson Pharmaceutical



Assay Description
The confluent HEK293 cells were co-transfected with DNA construct containing PPARdelta-Gal4 chimeric receptor and Gal4-luciferase reporter. The lucif...


J Med Chem 50: 3954-63 (2007)


Article DOI: 10.1021/jm070511x
BindingDB Entry DOI: 10.7270/Q2H41PR5
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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GSK



Assay Description
The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...


J Med Chem 50: 685-95 (2007)


Article DOI: 10.1021/jm058056x
BindingDB Entry DOI: 10.7270/Q2RN3669
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50384973
PNG
(CHEMBL2035057)
Show SMILES Cc1nc(sc1C(CC1CC1)Sc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H24F3NO3S2/c1-14-11-19(9-10-20(14)32-13-22(30)31)33-21(12-16-3-4-16)23-15(2)29-24(34-23)17-5-7-18(8-6-17)25(26,27)28/h5-11,16,21H,3-4,12-13H2,1-2H3,(H,30,31)
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n/an/an/an/a 1.10n/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


Eur J Med Chem 53: 190-202 (2012)


Article DOI: 10.1016/j.ejmech.2012.03.055
BindingDB Entry DOI: 10.7270/Q2JW8FX2
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50160403
PNG
(CHEMBL3786754)
Show SMILES Cc1cc(SCc2cnc(s2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-15(6-7-17(12)27-10-18(25)26)28-11-16-9-24-19(29-16)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 1.10n/an/an/an/a



Texas Tech University Health Sciences Center

Curated by ChEMBL


Assay Description
Agonist activity at human PPAR delta by cell based reporter assay


Bioorg Med Chem Lett 26: 1889-93 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.028
BindingDB Entry DOI: 10.7270/Q2NK3GZV
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50384972
PNG
(CHEMBL2035071)
Show SMILES CC(C)CC(Sc1ccc(OCC(O)=O)c(C)c1)c1sc(nc1C)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H26F3NO3S2/c1-14(2)11-21(33-19-9-10-20(15(3)12-19)32-13-22(30)31)23-16(4)29-24(34-23)17-5-7-18(8-6-17)25(26,27)28/h5-10,12,14,21H,11,13H2,1-4H3,(H,30,31)
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Seoul National University

Curated by ChEMBL


Assay Description
Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


Eur J Med Chem 53: 190-202 (2012)


Article DOI: 10.1016/j.ejmech.2012.03.055
BindingDB Entry DOI: 10.7270/Q2JW8FX2
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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n/an/an/an/a 1.20n/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Transactivation of human PPARdelta expressed in african green monkey CV1 cells by luciferase reporter gene assay


Bioorg Med Chem Lett 22: 4122-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.062
BindingDB Entry DOI: 10.7270/Q2TM7C5Q
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM28661
PNG
(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
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Zydus Research Centre

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta expressed in HepG2 cells cotransfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 h...


Bioorg Med Chem 19: 771-82 (2011)


Article DOI: 10.1016/j.bmc.2010.12.023
BindingDB Entry DOI: 10.7270/Q2PC32MN
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21818
PNG
(2-[(1S)-5-{3-[4-(4-ethoxy-1,3-thiazol-2-yl)phenoxy...)
Show SMILES CCOc1csc(n1)-c1ccc(OCCCOc2ccc3[C@H](CC(O)=O)CCc3c2)cc1
Show InChI InChI=1S/C25H27NO5S/c1-2-29-23-16-32-25(26-23)17-6-8-20(9-7-17)30-12-3-13-31-21-10-11-22-18(14-21)4-5-19(22)15-24(27)28/h6-11,14,16,19H,2-5,12-13,15H2,1H3,(H,27,28)/t19-/m0/s1
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Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50384975
PNG
(CHEMBL2035058)
Show SMILES Cc1nc(sc1C(Cc1c(F)cccc1C(F)(F)F)Sc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H22F7NO3S2/c1-15-12-19(10-11-23(15)40-14-25(38)39)41-24(13-20-21(29(34,35)36)4-3-5-22(20)30)26-16(2)37-27(42-26)17-6-8-18(9-7-17)28(31,32)33/h3-12,24H,13-14H2,1-2H3,(H,38,39)
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Seoul National University

Curated by ChEMBL


Assay Description
Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


Eur J Med Chem 53: 190-202 (2012)


Article DOI: 10.1016/j.ejmech.2012.03.055
BindingDB Entry DOI: 10.7270/Q2JW8FX2
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50384974
PNG
(CHEMBL2037587)
Show SMILES Cc1nc(sc1C(Cc1c(F)cccc1Cl)Sc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H22ClF4NO3S2/c1-15-12-19(10-11-23(15)37-14-25(35)36)38-24(13-20-21(29)4-3-5-22(20)30)26-16(2)34-27(39-26)17-6-8-18(9-7-17)28(31,32)33/h3-12,24H,13-14H2,1-2H3,(H,35,36)
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Seoul National University

Curated by ChEMBL


Assay Description
Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


Eur J Med Chem 53: 190-202 (2012)


Article DOI: 10.1016/j.ejmech.2012.03.055
BindingDB Entry DOI: 10.7270/Q2JW8FX2
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21797
PNG
(2-[(1S)-5-[3-(4-{4H,5H,6H-cyclopenta[d][1,3]thiazo...)
Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-c3nc4CCCc4s3)ccc12
Show InChI InChI=1S/C26H27NO4S/c28-25(29)16-19-6-5-18-15-21(11-12-22(18)19)31-14-2-13-30-20-9-7-17(8-10-20)26-27-23-3-1-4-24(23)32-26/h7-12,15,19H,1-6,13-14,16H2,(H,28,29)/t19-/m0/s1
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n/an/an/an/a 1.30n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21816
PNG
(2-[(1S)-5-{3-[4-(4-methoxy-1,3-thiazol-2-yl)phenox...)
Show SMILES COc1csc(n1)-c1ccc(OCCCOc2ccc3[C@H](CC(O)=O)CCc3c2)cc1
Show InChI InChI=1S/C24H25NO5S/c1-28-22-15-31-24(25-22)16-5-7-19(8-6-16)29-11-2-12-30-20-9-10-21-17(13-20)3-4-18(21)14-23(26)27/h5-10,13,15,18H,2-4,11-12,14H2,1H3,(H,26,27)/t18-/m0/s1
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n/an/an/an/a 1.30n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21804
PNG
(2-[(1S)-5-[3-(2-methoxy-4-{5H,6H,7H-pyrano[2,3-d][...)
Show SMILES COc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1nc2OCCCc2s1
Show InChI InChI=1S/C27H29NO6S/c1-31-23-15-19(27-28-26-24(35-27)4-2-11-34-26)7-10-22(23)33-13-3-12-32-20-8-9-21-17(14-20)5-6-18(21)16-25(29)30/h7-10,14-15,18H,2-6,11-13,16H2,1H3,(H,29,30)/t18-/m0/s1
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n/an/an/an/a 1.30n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50160402
PNG
(CHEMBL3787155)
Show SMILES C[C@H]1CN(C[C@@H](C)N1S(=O)(=O)c1cccc2C[C@@H](Cc12)C(O)=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N2O5S/c1-14-12-27(18-6-8-19(9-7-18)33-23(24,25)26)13-15(2)28(14)34(31,32)21-5-3-4-16-10-17(22(29)30)11-20(16)21/h3-9,14-15,17H,10-13H2,1-2H3,(H,29,30)/t14-,15+,17-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



Texas Tech University Health Sciences Center

Curated by ChEMBL


Assay Description
Agonist activity at PPAR delta (unknown origin)


Bioorg Med Chem Lett 26: 1889-93 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.028
BindingDB Entry DOI: 10.7270/Q2NK3GZV
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21780
PNG
(2-[(1S)-5-{3-[4-(1H-indol-6-yl)phenoxy]propoxy}-2,...)
Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-c3ccc4cc[nH]c4c3)ccc12
Show InChI InChI=1S/C28H27NO4/c30-28(31)18-23-5-4-22-16-25(10-11-26(22)23)33-15-1-14-32-24-8-6-19(7-9-24)21-3-2-20-12-13-29-27(20)17-21/h2-3,6-13,16-17,23,29H,1,4-5,14-15,18H2,(H,30,31)/t23-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21786
PNG
(2-[(1S)-5-{3-[2-propyl-4-(1,3-thiazol-2-yl)phenoxy...)
Show SMILES CCCc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1nccs1
Show InChI InChI=1S/C26H29NO4S/c1-2-4-20-15-21(26-27-11-14-32-26)7-10-24(20)31-13-3-12-30-22-8-9-23-18(16-22)5-6-19(23)17-25(28)29/h7-11,14-16,19H,2-6,12-13,17H2,1H3,(H,28,29)/t19-/m0/s1
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n/an/an/an/a 1.60n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM21767
PNG
(2-[(1S)-5-{3-[2-propyl-4-(trifluoromethyl)phenoxy]...)
Show SMILES CCCc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)C(F)(F)F
Show InChI InChI=1S/C24H27F3O4/c1-2-4-18-13-19(24(25,26)27)7-10-22(18)31-12-3-11-30-20-8-9-21-16(14-20)5-6-17(21)15-23(28)29/h7-10,13-14,17H,2-6,11-12,15H2,1H3,(H,28,29)/t17-/m0/s1
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n/an/an/an/a 1.60n/an/an/an/a



Bayer HealthCare Pharmaceuticals Corporation



Assay Description
Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...


J Med Chem 50: 984-1000 (2007)


Article DOI: 10.1021/jm061299k
BindingDB Entry DOI: 10.7270/Q2NK3C93
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50311788
PNG
(4'-butoxy-3'-((2-fluoro-4-(trifluoromethyl)benzami...)
Show SMILES CCCCOc1ccc(cc1CNC(=O)c1ccc(cc1F)C(F)(F)F)-c1cccc(C(O)=O)c1C
Show InChI InChI=1S/C27H25F4NO4/c1-3-4-12-36-24-11-8-17(20-6-5-7-21(16(20)2)26(34)35)13-18(24)15-32-25(33)22-10-9-19(14-23(22)28)27(29,30)31/h5-11,13-14H,3-4,12,15H2,1-2H3,(H,32,33)(H,34,35)
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n/an/an/an/a 1.60n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Partial agonist activity at human recombinant PPARdelta LBD expressed in HEK293 cells cotransfected with Gal4 assessed as beta-galactosidase activity...


Bioorg Med Chem 18: 7164-73 (2010)


Article DOI: 10.1016/j.bmc.2010.08.041
BindingDB Entry DOI: 10.7270/Q2862GN7
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50311788
PNG
(4'-butoxy-3'-((2-fluoro-4-(trifluoromethyl)benzami...)
Show SMILES CCCCOc1ccc(cc1CNC(=O)c1ccc(cc1F)C(F)(F)F)-c1cccc(C(O)=O)c1C
Show InChI InChI=1S/C27H25F4NO4/c1-3-4-12-36-24-11-8-17(20-6-5-7-21(16(20)2)26(34)35)13-18(24)15-32-25(33)22-10-9-19(14-23(22)28)27(29,30)31/h5-11,13-14H,3-4,12,15H2,1-2H3,(H,32,33)(H,34,35)
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n/an/an/an/a 1.60n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Partial agonist activity at PPARdelta


J Med Chem 54: 1539-54 (2011)


Article DOI: 10.1021/jm101356p
BindingDB Entry DOI: 10.7270/Q27S7P30
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50384976
PNG
(CHEMBL2037577)
Show SMILES Cc1nc(sc1C(Cc1ccccc1)Sc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H24F3NO3S2/c1-17-14-22(12-13-23(17)35-16-25(33)34)36-24(15-19-6-4-3-5-7-19)26-18(2)32-27(37-26)20-8-10-21(11-9-20)28(29,30)31/h3-14,24H,15-16H2,1-2H3,(H,33,34)
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n/an/an/an/a 1.60n/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


Eur J Med Chem 53: 190-202 (2012)


Article DOI: 10.1016/j.ejmech.2012.03.055
BindingDB Entry DOI: 10.7270/Q2JW8FX2
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50192837
PNG
(CHEMBL3964816)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(Cl)c1
Show InChI InChI=1S/C26H26ClNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 1.60n/an/an/an/a



Temple University

Curated by ChEMBL


Assay Description
Transactivation of ProLink tagged human PPARdelta transfected in CHO-K1 cells assessed as interaction with EA labelled SRCP after 3 to 16 hrs by beta...


ACS Med Chem Lett 7: 824-5 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00301
BindingDB Entry DOI: 10.7270/Q2WH2RZ8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50311788
PNG
(4'-butoxy-3'-((2-fluoro-4-(trifluoromethyl)benzami...)
Show SMILES CCCCOc1ccc(cc1CNC(=O)c1ccc(cc1F)C(F)(F)F)-c1cccc(C(O)=O)c1C
Show InChI InChI=1S/C27H25F4NO4/c1-3-4-12-36-24-11-8-17(20-6-5-7-21(16(20)2)26(34)35)13-18(24)15-32-25(33)22-10-9-19(14-23(22)28)27(29,30)31/h5-11,13-14H,3-4,12,15H2,1-2H3,(H,32,33)(H,34,35)
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n/an/an/an/a 1.60n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at PPARdelta receptor expressed in HEK293 cells cotransfected with GAL4 by transactivation assay


Bioorg Med Chem Lett 19: 6595-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.021
BindingDB Entry DOI: 10.7270/Q2736R23
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (PPAR delta)


(Homo sapiens (Human))
BDBM50214195
PNG
(2-{3-[(2-fluoro-4-trifluoromethylbenzoylamino)-met...)
Show SMILES CCCOc1ccc(CC(CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C23H25F4NO4/c1-3-9-32-20-8-5-14(10-15(4-2)22(30)31)11-16(20)13-28-21(29)18-7-6-17(12-19(18)24)23(25,26)27/h5-8,11-12,15H,3-4,9-10,13H2,1-2H3,(H,28,29)(H,30,31)
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n/an/an/an/a 1.70n/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Effect on PPARdelta transactivation activity in HEK293 cells


Bioorg Med Chem 15: 5177-90 (2007)


Article DOI: 10.1016/j.bmc.2007.05.023
BindingDB Entry DOI: 10.7270/Q2QZ29P7
More data for this
Ligand-Target Pair
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