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Compile Data Set for Download or QSAR

Found 2557 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 5A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50100662
PNG
(CHEMBL553371 | CHEMBL77971 | methyl 2-(4-aminophen...)
Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1
Show InChI InChI=1S/C32H29N3O7/c1-38-26-15-19(16-27(39-2)30(26)40-3)28-24-13-12-23(42-18-21-7-5-6-14-34-21)17-25(24)31(36)35(29(28)32(37)41-4)22-10-8-20(33)9-11-22/h5-17H,18,33H2,1-4H3
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n/an/an/an/a 7.90n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/an/an/a 8.70n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50100659
PNG
(CHEMBL544289 | methyl 2-(4-aminophenyl)-1-oxo-7-(3...)
Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3cccnc3)cc2c(=O)n1-c1ccc(N)cc1
Show InChI InChI=1S/C32H29N3O7/c1-38-26-14-20(15-27(39-2)30(26)40-3)28-24-12-11-23(42-18-19-6-5-13-34-17-19)16-25(24)31(36)35(29(28)32(37)41-4)22-9-7-21(33)8-10-22/h5-17H,18,33H2,1-4H3
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n/an/an/an/a 9.5n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50100670
PNG
(CHEMBL553786 | methyl 2-(4-aminophenyl)-1-oxo-7-(4...)
Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccncc3)cc2c(=O)n1-c1ccc(N)cc1
Show InChI InChI=1S/C32H29N3O7/c1-38-26-15-20(16-27(39-2)30(26)40-3)28-24-10-9-23(42-18-19-11-13-34-14-12-19)17-25(24)31(36)35(29(28)32(37)41-4)22-7-5-21(33)6-8-22/h5-17H,18,33H2,1-4H3
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n/an/an/an/a 12n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050617
PNG
(6-(5-Amino-2-propoxy-phenyl)-1-ethyl-3-methyl-1,5-...)
Show SMILES CCCOc1ccc(N)cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C17H21N5O2/c1-4-8-24-13-7-6-11(18)9-12(13)15-19-16-14(17(23)20-15)10(3)21-22(16)5-2/h6-7,9H,4-5,8,18H2,1-3H3,(H,19,20,23)
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n/an/an/an/a 20n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050580
PNG
(CHEMBL416267 | N-[3-(1-Ethyl-3-methyl-4-oxo-4,5-di...)
Show SMILES CCCOc1ccc(NC(C)=O)cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C19H23N5O3/c1-5-9-27-15-8-7-13(20-12(4)25)10-14(15)17-21-18-16(19(26)22-17)11(3)23-24(18)6-2/h7-8,10H,5-6,9H2,1-4H3,(H,20,25)(H,21,22,26)
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n/an/an/an/a 30n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50100674
PNG
(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Show SMILES COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1
Show InChI InChI=1S/C32H29N3O6/c1-19-27(38-2)15-20(16-28(19)39-3)29-25-13-12-24(41-18-22-7-5-6-14-34-22)17-26(25)31(36)35(30(29)32(37)40-4)23-10-8-21(33)9-11-23/h5-17H,18,33H2,1-4H3
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n/an/an/an/a 37n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050603
PNG
(1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydr o-1H-pyrazolo[...)
Show SMILES CCCOc1ccc(NC(=S)NC(=O)OCC)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C20H24N6O4S/c1-5-9-30-14-8-7-12(21-19(31)24-20(28)29-6-2)10-13(14)16-22-17-15(18(27)23-16)11(3)25-26(17)4/h7-8,10H,5-6,9H2,1-4H3,(H,22,23,27)(H2,21,24,28,31)
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n/an/an/an/a 40n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050584
PNG
(1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3...)
Show SMILES CCCOc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C23H23FN6O3/c1-4-11-33-18-10-9-16(26-23(32)25-15-7-5-14(24)6-8-15)12-17(18)20-27-21-19(22(31)28-20)13(2)29-30(21)3/h5-10,12H,4,11H2,1-3H3,(H2,25,26,32)(H,27,28,31)
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n/an/an/an/a 40n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050582
PNG
(CHEMBL43443 | N-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro...)
Show SMILES CCCOc1ccc(NC(C)=O)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C18H21N5O3/c1-5-8-26-14-7-6-12(19-11(3)24)9-13(14)16-20-17-15(18(25)21-16)10(2)22-23(17)4/h6-7,9H,5,8H2,1-4H3,(H,19,24)(H,20,21,25)
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n/an/an/an/a 40n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/an/an/a 42n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Relaxant effect on rabbit corpus cavernosal tissue strips


J Med Chem 44: 1025-7 (2001)


Article DOI: 10.1021/jm0155042
BindingDB Entry DOI: 10.7270/Q2154G8J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50100673
PNG
(CHEMBL538498 | methyl 2-(4-aminophenyl)-4-(4-bromo...)
Show SMILES COC(=O)c1c(-c2cc(OC)c(Br)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1
Show InChI InChI=1S/C31H26BrN3O6/c1-38-25-14-18(15-26(39-2)28(25)32)27-23-12-11-22(41-17-20-6-4-5-13-34-20)16-24(23)30(36)35(29(27)31(37)40-3)21-9-7-19(33)8-10-21/h4-16H,17,33H2,1-3H3
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n/an/an/an/a 44n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50098220
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-1-ethyl-1H-pyra...)
Show SMILES CCn1ncc2c(NCc3ccc(OC)c(Cl)c3)c(cnc12)C(=O)NCc1ccncc1
Show InChI InChI=1S/C23H23ClN6O2/c1-3-30-22-17(14-29-30)21(26-12-16-4-5-20(32-2)19(24)10-16)18(13-27-22)23(31)28-11-15-6-8-25-9-7-15/h4-10,13-14H,3,11-12H2,1-2H3,(H,26,27)(H,28,31)
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n/an/an/an/a 44n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Relaxant effect on rabbit corpus cavernosal tissue strips


J Med Chem 44: 1025-7 (2001)


Article DOI: 10.1021/jm0155042
BindingDB Entry DOI: 10.7270/Q2154G8J
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050597
PNG
(1-Ethyl-3-methyl-6-(5-nitro-2-propoxy-phenyl)-1,5-...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1)[N+]([O-])=O
Show InChI InChI=1S/C17H19N5O4/c1-4-8-26-13-7-6-11(22(24)25)9-12(13)15-18-16-14(17(23)19-15)10(3)20-21(16)5-2/h6-7,9H,4-5,8H2,1-3H3,(H,18,19,23)
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n/an/an/an/a 50n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050596
PNG
(1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3...)
Show SMILES CCCOc1ccc(NC(=O)NCC)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C19H24N6O3/c1-5-9-28-14-8-7-12(21-19(27)20-6-2)10-13(14)16-22-17-15(18(26)23-16)11(3)24-25(17)4/h7-8,10H,5-6,9H2,1-4H3,(H2,20,21,27)(H,22,23,26)
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n/an/an/an/a 50n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050585
PNG
(1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3...)
Show SMILES CCCOc1ccc(NC(=S)NCC)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C19H24N6O2S/c1-5-9-27-14-8-7-12(21-19(28)20-6-2)10-13(14)16-22-17-15(18(26)23-16)11(3)24-25(17)4/h7-8,10H,5-6,9H2,1-4H3,(H2,20,21,28)(H,22,23,26)
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n/an/an/an/a 60n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050575
PNG
(1,3-Dimethyl-6-(5-nitro-2-propoxy-phenyl)-1,5-dihy...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)[N+]([O-])=O
Show InChI InChI=1S/C16H17N5O4/c1-4-7-25-12-6-5-10(21(23)24)8-11(12)14-17-15-13(16(22)18-14)9(2)19-20(15)3/h5-6,8H,4,7H2,1-3H3,(H,17,18,22)
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n/an/an/an/a 100n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050618
PNG
(CHEMBL291178 | [3-(1,3-Dimethyl-4-oxo-4,5-dihydro-...)
Show SMILES CCCOc1ccc(NC(=O)OC)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C18H21N5O4/c1-5-8-27-13-7-6-11(19-18(25)26-4)9-12(13)15-20-16-14(17(24)21-15)10(2)22-23(16)3/h6-7,9H,5,8H2,1-4H3,(H,19,25)(H,20,21,24)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50100656
PNG
(2-(4-Amino-phenyl)-7-benzyloxy-1-oxo-4-(3,4,5-trim...)
Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccc3)cc2c(=O)n1-c1ccc(N)cc1
Show InChI InChI=1S/C33H30N2O7/c1-38-27-16-21(17-28(39-2)31(27)40-3)29-25-15-14-24(42-19-20-8-6-5-7-9-20)18-26(25)32(36)35(30(29)33(37)41-4)23-12-10-22(34)11-13-23/h5-18H,19,34H2,1-4H3
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n/an/an/an/a 130n/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Relaxant effect on isolated rabbit corpus cavernosum


J Med Chem 44: 2204-18 (2001)


Article DOI: 10.1021/jm000558h
BindingDB Entry DOI: 10.7270/Q2QR4XT5
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050619
PNG
(3-Methyl-6-(2-propoxy-phenyl)-1-propyl-1,5-dihydro...)
Show SMILES CCCOc1ccccc1-c1nc2n(CCC)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C18H22N4O2/c1-4-10-22-17-15(12(3)21-22)18(23)20-16(19-17)13-8-6-7-9-14(13)24-11-5-2/h6-9H,4-5,10-11H2,1-3H3,(H,19,20,23)
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n/an/an/an/a 150n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050588
PNG
(1-tert-Butyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dih...)
Show SMILES CCCOc1ccccc1-c1nc2n(nc(C)c2c(=O)[nH]1)C(C)(C)C
Show InChI InChI=1S/C19H24N4O2/c1-6-11-25-14-10-8-7-9-13(14)16-20-17-15(18(24)21-16)12(2)22-23(17)19(3,4)5/h7-10H,6,11H2,1-5H3,(H,20,21,24)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050614
PNG
(1-Ethyl-3-methyl-6-[5-(2-phenyl-thiazol-4-yl)-2-pr...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C26H25N5O2S/c1-4-13-33-21-12-11-18(20-15-34-26(27-20)17-9-7-6-8-10-17)14-19(21)23-28-24-22(25(32)29-23)16(3)30-31(24)5-2/h6-12,14-15H,4-5,13H2,1-3H3,(H,28,29,32)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050607
PNG
(1,3-Dimethyl-6-(2-propoxy-phenyl)-1,5-dihydro-pyra...)
Show SMILES CCCOc1ccccc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C16H18N4O2/c1-4-9-22-12-8-6-5-7-11(12)14-17-15-13(16(21)18-14)10(2)19-20(15)3/h5-8H,4,9H2,1-3H3,(H,17,18,21)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050611
PNG
(1,3-Dimethyl-6-[5-(2-methyl-thiazol-4-yl)-2-propox...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)-c1csc(C)n1
Show InChI InChI=1S/C20H21N5O2S/c1-5-8-27-16-7-6-13(15-10-28-12(3)21-15)9-14(16)18-22-19-17(20(26)23-18)11(2)24-25(19)4/h6-7,9-10H,5,8H2,1-4H3,(H,22,23,26)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050593
PNG
(1,3-Dimethyl-6-[5-(2-phenyl-thiazol-4-yl)-2-propox...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C25H23N5O2S/c1-4-12-32-20-11-10-17(19-14-33-25(26-19)16-8-6-5-7-9-16)13-18(20)22-27-23-21(24(31)28-22)15(2)29-30(23)3/h5-11,13-14H,4,12H2,1-3H3,(H,27,28,31)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050600
PNG
(CHEMBL298294 | N-[3-(1-Ethyl-3-methyl-4-oxo-4,5-di...)
Show SMILES CCCOc1ccc(NS(C)(=O)=O)cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C18H23N5O4S/c1-5-9-27-14-8-7-12(22-28(4,25)26)10-13(14)16-19-17-15(18(24)20-16)11(3)21-23(17)6-2/h7-8,10,22H,5-6,9H2,1-4H3,(H,19,20,24)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050581
PNG
(1,3-Dimethyl-6-(2-propoxy-5-thiophen-2-yl-phenyl)-...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)-c1cccs1
Show InChI InChI=1S/C20H20N4O2S/c1-4-9-26-15-8-7-13(16-6-5-10-27-16)11-14(15)18-21-19-17(20(25)22-18)12(2)23-24(19)3/h5-8,10-11H,4,9H2,1-3H3,(H,21,22,25)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050621
PNG
(1,3-Dimethyl-6-[5-(2-morpholin-4-yl-acetyl)-2-prop...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)C(=O)CN1CCOCC1
Show InChI InChI=1S/C22H27N5O4/c1-4-9-31-18-6-5-15(17(28)13-27-7-10-30-11-8-27)12-16(18)20-23-21-19(22(29)24-20)14(2)25-26(21)3/h5-6,12H,4,7-11,13H2,1-3H3,(H,23,24,29)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050615
PNG
(6-(5-Dimethylamino-2-propoxy-phenyl)-1,3-dimethyl-...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)N(C)C
Show InChI InChI=1S/C18H23N5O2/c1-6-9-25-14-8-7-12(22(3)4)10-13(14)16-19-17-15(18(24)20-16)11(2)21-23(17)5/h7-8,10H,6,9H2,1-5H3,(H,19,20,24)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050606
PNG
(6-(5-Amino-2-propoxy-phenyl)-1,3-dimethyl-1,5-dihy...)
Show SMILES CCCOc1ccc(N)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C16H19N5O2/c1-4-7-23-12-6-5-10(17)8-11(12)14-18-15-13(16(22)19-14)9(2)20-21(15)3/h5-6,8H,4,7,17H2,1-3H3,(H,18,19,22)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050598
PNG
(CHEMBL45367 | N-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro...)
Show SMILES CCCOc1ccc(NS(C)(=O)=O)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C17H21N5O4S/c1-5-8-26-13-7-6-11(21-27(4,24)25)9-12(13)15-18-16-14(17(23)19-15)10(2)20-22(16)3/h6-7,9,21H,5,8H2,1-4H3,(H,18,19,23)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050609
PNG
(1-Benzyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dihydro...)
Show SMILES CCCOc1ccccc1-c1nc2n(Cc3ccccc3)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C22H22N4O2/c1-3-13-28-18-12-8-7-11-17(18)20-23-21-19(22(27)24-20)15(2)25-26(21)14-16-9-5-4-6-10-16/h4-12H,3,13-14H2,1-2H3,(H,23,24,27)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050592
PNG
(CHEMBL46621 | N-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro...)
Show SMILES CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C23H31N7O3/c1-5-12-33-18-7-6-16(24-19(31)14-30-10-8-28(3)9-11-30)13-17(18)21-25-22-20(23(32)26-21)15(2)27-29(22)4/h6-7,13H,5,8-12,14H2,1-4H3,(H,24,31)(H,25,26,32)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050590
PNG
(1,3-Dimethyl-6-[5-(4-methyl-thiazol-2-yl)-2-propox...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)-c1nc(C)cs1
Show InChI InChI=1S/C20H21N5O2S/c1-5-8-27-15-7-6-13(20-21-11(2)10-28-20)9-14(15)17-22-18-16(19(26)23-17)12(3)24-25(18)4/h6-7,9-10H,5,8H2,1-4H3,(H,22,23,26)
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n/an/an/an/a 450n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050578
PNG
(5-Methyl-2-(2-propoxy-phenyl)-3H-thieno[2,3-d]pyri...)
Show SMILES CCCOc1ccccc1-c1nc2scc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C16H16N2O2S/c1-3-8-20-12-7-5-4-6-11(12)14-17-15(19)13-10(2)9-21-16(13)18-14/h4-7,9H,3,8H2,1-2H3,(H,17,18,19)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050616
PNG
(1-Butyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dihydro-...)
Show SMILES CCCCn1nc(C)c2c1nc([nH]c2=O)-c1ccccc1OCCC
Show InChI InChI=1S/C19H24N4O2/c1-4-6-11-23-18-16(13(3)22-23)19(24)21-17(20-18)14-9-7-8-10-15(14)25-12-5-2/h7-10H,4-6,11-12H2,1-3H3,(H,20,21,24)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050579
PNG
(CHEMBL42886 | [3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1...)
Show SMILES CCCOc1ccc(NC(N)=O)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C17H20N6O3/c1-4-7-26-12-6-5-10(19-17(18)25)8-11(12)14-20-15-13(16(24)21-14)9(2)22-23(15)3/h5-6,8H,4,7H2,1-3H3,(H3,18,19,25)(H,20,21,24)
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Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050605
PNG
(CHEMBL297864 | [3-(1,3-Dimethyl-4-oxo-4,5-dihydro-...)
Show SMILES CCCOc1ccc(NC(N)=S)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C17H20N6O2S/c1-4-7-25-12-6-5-10(19-17(18)26)8-11(12)14-20-15-13(16(24)21-14)9(2)22-23(15)3/h5-6,8H,4,7H2,1-3H3,(H3,18,19,26)(H,20,21,24)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050612
PNG
(6-(2-Isopropoxy-phenyl)-1,3-dimethyl-1,5-dihydro-p...)
Show SMILES CC(C)Oc1ccccc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C16H18N4O2/c1-9(2)22-12-8-6-5-7-11(12)14-17-15-13(16(21)18-14)10(3)19-20(15)4/h5-9H,1-4H3,(H,17,18,21)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050587
PNG
(2-(2-Propoxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-o...)
Show SMILES CCCOc1ccccc1-c1nc2ccsc2c(=O)[nH]1
Show InChI InChI=1S/C15H14N2O2S/c1-2-8-19-12-6-4-3-5-10(12)14-16-11-7-9-20-13(11)15(18)17-14/h3-7,9H,2,8H2,1H3,(H,16,17,18)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050624
PNG
(6-(5-Dimethylamino-2-propoxy-phenyl)-1-ethyl-3-met...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1)N(C)C
Show InChI InChI=1S/C19H25N5O2/c1-6-10-26-15-9-8-13(23(4)5)11-14(15)17-20-18-16(19(25)21-17)12(3)22-24(18)7-2/h8-9,11H,6-7,10H2,1-5H3,(H,20,21,25)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050574
PNG
(3-Methyl-6-(2-propoxy-phenyl)-1-(2,2,2-trifluoro-e...)
Show SMILES CCCOc1ccccc1-c1nc2n(CC(F)(F)F)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C17H17F3N4O2/c1-3-8-26-12-7-5-4-6-11(12)14-21-15-13(16(25)22-14)10(2)23-24(15)9-17(18,19)20/h4-7H,3,8-9H2,1-2H3,(H,21,22,25)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050583
PNG
(3-Methyl-6-(2-propoxy-phenyl)-5H-isothiazolo[3,4-d...)
Show SMILES CCCOc1ccccc1-c1nc2nsc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C15H15N3O2S/c1-3-8-20-11-7-5-4-6-10(11)13-16-14-12(15(19)17-13)9(2)21-18-14/h4-7H,3,8H2,1-2H3,(H,16,17,18,19)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050591
PNG
(7-Methyl-2-(2-propoxy-phenyl)-3H-thieno[3,2-d]pyri...)
Show SMILES CCCOc1ccccc1-c1nc2c(C)csc2c(=O)[nH]1
Show InChI InChI=1S/C16H16N2O2S/c1-3-8-20-12-7-5-4-6-11(12)15-17-13-10(2)9-21-14(13)16(19)18-15/h4-7,9H,3,8H2,1-2H3,(H,17,18,19)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050594
PNG
(2-(2-Propoxy-phenyl)-3H-pyrido[3,4-d]pyrimidin-4-o...)
Show SMILES CCCOc1ccccc1-c1nc2cnccc2c(=O)[nH]1
Show InChI InChI=1S/C16H15N3O2/c1-2-9-21-14-6-4-3-5-12(14)15-18-13-10-17-8-7-11(13)16(20)19-15/h3-8,10H,2,9H2,1H3,(H,18,19,20)
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n/an/an/an/a 2.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050608
PNG
(6-(2-Ethoxy-phenyl)-1,3-dimethyl-1,5-dihydro-pyraz...)
Show SMILES CCOc1ccccc1-c1nc2n(C)nc(C)c2c(=O)[nH]1
Show InChI InChI=1S/C15H16N4O2/c1-4-21-11-8-6-5-7-10(11)13-16-14-12(15(20)17-13)9(2)18-19(14)3/h5-8H,4H2,1-3H3,(H,16,17,20)
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n/an/an/an/a 2.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50040377
PNG
(2-(2-Propoxy-phenyl)-1,7-dihydro-purin-6-one | 2-(...)
Show SMILES CCCOc1ccccc1-c1nc2nc[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C14H14N4O2/c1-2-7-20-10-6-4-3-5-9(10)12-17-13-11(14(19)18-12)15-8-16-13/h3-6,8H,2,7H2,1H3,(H2,15,16,17,18,19)
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n/an/an/an/a 2.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050604
PNG
(2-(2-Propoxy-phenyl)-3H-thieno[2,3-d]pyrimidin-4-o...)
Show SMILES CCCOc1ccccc1-c1nc2sccc2c(=O)[nH]1
Show InChI InChI=1S/C15H14N2O2S/c1-2-8-19-12-6-4-3-5-10(12)13-16-14(18)11-7-9-20-15(11)17-13/h3-7,9H,2,8H2,1H3,(H,16,17,18)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM50050625
PNG
(2-(2-Propoxy-phenyl)-3H-pyrimido[4,5-d]pyrimidin-4...)
Show SMILES CCCOc1ccccc1-c1nc2ncncc2c(=O)[nH]1
Show InChI InChI=1S/C15H14N4O2/c1-2-7-21-12-6-4-3-5-10(12)14-18-13-11(15(20)19-14)8-16-9-17-13/h3-6,8-9H,2,7H2,1H3,(H,16,17,18,19,20)
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n/an/an/an/a 7.50E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Rattus norvegicus)
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/an/an/a 9.00E+3n/an/an/an/a



Laboratories Glaxo Wellcome Centre de Recherches

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)


J Med Chem 39: 1635-44 (1996)


Article DOI: 10.1021/jm950812j
BindingDB Entry DOI: 10.7270/Q2057F1T
More data for this
Ligand-Target Pair
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