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Compile Data Set for Download or QSAR

Found 14 hits Enz. Inhib. hit(s) with Target = 'Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50526578
PNG
(CHEMBL4468490)
Show SMILES [Na+].Nc1ncnc2n(ccc12)[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C11H13N4O6P.Na/c12-9-5-1-2-15(10(5)14-4-13-9)11-7(16)8-6(20-11)3-19-22(17,18)21-8;/h1-2,4,6-8,11,16H,3H2,(H,17,18)(H2,12,13,14);/q;+1/p-1/t6-,7-,8-,11-;/m1./s1
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n/an/an/an/a 15n/an/an/an/a



University Hospital Jena

Curated by ChEMBL


Assay Description
Activation of recombinant mouse HCN2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude at -30 mV holding potential by patc...


Bioorg Med Chem 27: 1704-1713 (2019)


Article DOI: 10.1016/j.bmc.2019.03.024
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326989
PNG
(3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(meth...)
Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326992
PNG
(CHEMBL471737 | ivabradine)
Show SMILES COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC
Show InChI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1
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n/an/an/an/a 4.52E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326988
PNG
(3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...)
Show SMILES COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3
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n/an/an/an/a 5.45E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326991
PNG
(3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Show SMILES COc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6+
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n/an/an/an/a 1.72E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326990
PNG
(3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)pr...)
Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m0/s1
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n/an/an/an/a 1.83E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50535442
PNG
(CHEMBL4453882)
Show SMILES COc1ccc(CCN(C)[C@@H]2CCC[C@@H](C2)N2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C29H40N2O5/c1-30(13-11-20-9-10-25(33-2)26(15-20)34-3)23-7-6-8-24(19-23)31-14-12-21-16-27(35-4)28(36-5)17-22(21)18-29(31)32/h9-10,15-17,23-24H,6-8,11-14,18-19H2,1-5H3/t23-,24+/m1/s1
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n/an/an/an/a 1.94E+4n/an/an/an/a



University of Florence

Curated by ChEMBL


Assay Description
Inhibition of mouse HCN2 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by pat...


ACS Med Chem Lett 10: 584-589 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00587
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326993
PNG
(3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Show SMILES COc1ccc(CCN(C)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6-
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n/an/an/an/a 2.46E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326987
PNG
(3-((Z)-4-(((S)-2-(3,4-dimethoxyphenyl)propyl)(meth...)
Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m1/s1
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n/an/an/an/a 2.55E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326986
PNG
(3,3'-((2Z,2'Z)-4,4'-((S)-2-(3,4-dimethoxyphenyl)pr...)
Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m1/s1
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n/an/an/an/a 5.01E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Mus musculus)
BDBM50326985
PNG
(3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...)
Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8-
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n/an/an/an/a 1.47E+5n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


J Med Chem 53: 6773-7 (2010)


Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Homo sapiens (Human))
BDBM50258216
PNG
(CHEMBL4105630)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc(cn1)C#N
Show InChI InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Sage Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Inhibition of HCN2 (unknown origin) by patch clamp assay


J Med Chem 60: 7810-7819 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00846
BindingDB Entry DOI: 10.7270/Q2ZK5K4W
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Homo sapiens (Human))
BDBM50419083
PNG
(CHEMBL1823882)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1
Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24)
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n/an/a 5.01E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN2 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


(Homo sapiens (Human))
BDBM50257064
PNG
(CHEMBL2386850)
Show SMILES Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C16H12FN5O2/c1-10-4-12(24-13-7-18-9-19-8-13)5-14(21-10)16(23)22-15-3-2-11(17)6-20-15/h2-9H,1H3,(H,20,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science

Curated by ChEMBL


Assay Description
Inhibition of human HCN2 expressed in CHO cells by automated patch clamp assay


J Med Chem 60: 5072-5085 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00410
BindingDB Entry DOI: 10.7270/Q2JH3PM7
More data for this
Ligand-Target Pair