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Compile Data Set for Download or QSAR

Found 76 hits Enz. Inhib. hit(s) with Target = 'Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139706
PNG
(3-(2,4-Dinitro-phenyl)-4-nitro-5-trifluoromethyl-1...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4F3N5O6/c11-10(12,13)9-8(18(23)24)7(14-15-9)5-2-1-4(16(19)20)3-6(5)17(21)22/h1-3H,(H,14,15)
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n/an/an/an/a 70n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50378565
PNG
(CHEMBL568795)
Show SMILES Clc1ccc2c(c1)N=C(NC1CCC1)NS2(=O)=O
Show InChI InChI=1S/C11H12ClN3O2S/c12-7-4-5-10-9(6-7)14-11(15-18(10,16)17)13-8-2-1-3-8/h4-6,8H,1-3H2,(H2,13,14,15)
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n/an/an/an/a 80n/an/an/an/a



Universite de Liege

Curated by ChEMBL


Assay Description
Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assay


J Med Chem 53: 147-54 (2010)


Article DOI: 10.1021/jm9010093
BindingDB Entry DOI: 10.7270/Q2C82B7T
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190502
PNG
(6-bromo-3-(1-methylcyclopropyl)amino-4H-thieno[3,2...)
Show SMILES CC1(CC1)NC1=Nc2cc(Br)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10BrN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/an/an/a 160n/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190500
PNG
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1
Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18)
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n/an/an/an/a 180n/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/an/an/a 190n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/an/an/a 190n/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119272
PNG
((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Show SMILES Clc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H12ClN3O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3H2,(H2,13,14,15)
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n/an/an/an/a 196n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119272
PNG
((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Show SMILES Clc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H12ClN3O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3H2,(H2,13,14,15)
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n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50130735
PNG
((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Show SMILES CC(C)NC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O2S/c1-6(2)12-10-13-8-4-3-7(11)5-9(8)17(15,16)14-10/h3-6H,1-2H3,(H2,12,13,14)
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n/an/an/an/a 250n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119269
PNG
(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Show SMILES Fc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H12FN3O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3H2,(H2,13,14,15)
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n/an/an/an/a 356n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119269
PNG
(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Show SMILES Fc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H12FN3O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3H2,(H2,13,14,15)
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n/an/an/an/a 400n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/an/an/a 450n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190501
PNG
(6-chloro-3-{[1-(trifluoromethyl)cyclopropyl]-amino...)
Show SMILES FC(F)(F)C1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H7ClF3N3O2S2/c10-5-3-4-6(19-5)20(17,18)16-7(14-4)15-8(1-2-8)9(11,12)13/h3H,1-2H2,(H2,14,15,16)
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n/an/an/an/a 530n/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119274
PNG
(CHEMBL100793 | Cyclobutyl-(7-nitro-1,1-dioxo-1,4-d...)
Show SMILES [O-][N+](=O)c1ccc2[N-]\C(NS(=O)(=O)c2c1)=[NH+]\C1CCC1
Show InChI InChI=1S/C11H11N4O4S/c16-15(17)8-4-5-9-10(6-8)20(18,19)14-11(13-9)12-7-2-1-3-7/h4-7H,1-3H2,(H-,12,13,14)/q-1/p+1
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n/an/an/an/a 530n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139709
PNG
(3-(2,4-Bis-trifluoromethyl-phenyl)-4-nitro-5-trifl...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(cc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H4F9N3O2/c13-10(14,15)4-1-2-5(6(3-4)11(16,17)18)7-8(24(25)26)9(23-22-7)12(19,20)21/h1-3H,(H,22,23)
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n/an/an/an/a 540n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139705
PNG
(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-1H-py...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H5F3N4O4/c11-10(12,13)9-8(17(20)21)7(14-15-9)5-1-3-6(4-2-5)16(18)19/h1-4H,(H,14,15)
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n/an/an/an/a 700n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190496
PNG
(6-chloro-3-(1-phenylcyclopropyl)amino-4H-thieno[3,...)
Show SMILES Clc1cc2N=C(NC3(CC3)c3ccccc3)NS(=O)(=O)c2s1
Show InChI InChI=1S/C14H12ClN3O2S2/c15-11-8-10-12(21-11)22(19,20)18-13(16-10)17-14(6-7-14)9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H2,16,17,18)
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n/an/an/an/a 810n/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139704
PNG
(3-(2,4-Difluoro-phenyl)-4-nitro-5-trifluoromethyl-...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(F)cc1F
Show InChI InChI=1S/C10H4F5N3O2/c11-4-1-2-5(6(12)3-4)7-8(18(19)20)9(17-16-7)10(13,14)15/h1-3H,(H,16,17)
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n/an/an/an/a 1.15E+3n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119270
PNG
(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Show SMILES O=S1(=O)NC(NC2CCC2)=Nc2ccccc12
Show InChI InChI=1S/C11H13N3O2S/c15-17(16)10-7-2-1-6-9(10)13-11(14-17)12-8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,12,13,14)
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n/an/an/an/a 1.96E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119270
PNG
(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Show SMILES O=S1(=O)NC(NC2CCC2)=Nc2ccccc12
Show InChI InChI=1S/C11H13N3O2S/c15-17(16)10-7-2-1-6-9(10)13-11(14-17)12-8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,12,13,14)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119271
PNG
(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Show SMILES COc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C12H15N3O3S/c1-18-9-5-6-10-11(7-9)19(16,17)15-12(14-10)13-8-3-2-4-8/h5-8H,2-4H2,1H3,(H2,13,14,15)
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n/an/an/an/a 3.87E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119271
PNG
(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Show SMILES COc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C12H15N3O3S/c1-18-9-5-6-10-11(7-9)19(16,17)15-12(14-10)13-8-3-2-4-8/h5-8H,2-4H2,1H3,(H2,13,14,15)
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n/an/an/an/a 4.00E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 8.80E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 8.80E+3n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210319
PNG
(4-amino-6-methoxy-2-(trifluoromethyl)quinoline-3-c...)
Show SMILES COc1ccc2nc(c(C#N)c(N)c2c1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3O/c1-19-6-2-3-9-7(4-6)10(17)8(5-16)11(18-9)12(13,14)15/h2-4H,1H3,(H2,17,18)
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n/an/an/an/a 1.50E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210320
PNG
(CHEMBL226918 | [(2Z)-4-(4-fluorophenyl)-2-[(4-fluo...)
Show SMILES OCCn1c(cs\c1=N/c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H14F2N2OS/c18-13-3-1-12(2-4-13)16-11-23-17(21(16)9-10-22)20-15-7-5-14(19)6-8-15/h1-8,11,22H,9-10H2/b20-17-
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n/an/an/an/a 2.10E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 2.35E+4n/an/an/an/a



Universite de Liege

Curated by ChEMBL


Assay Description
Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assay


J Med Chem 53: 147-54 (2010)


Article DOI: 10.1021/jm9010093
BindingDB Entry DOI: 10.7270/Q2C82B7T
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM56470
PNG
(2-(2-Imino-3-methyl-2,3-dihydro-benzoimidazol-1-yl...)
Show SMILES Cn1c2ccccc2n(CC(=O)c2cccs2)c1=N
Show InChI InChI=1S/C14H13N3OS/c1-16-10-5-2-3-6-11(10)17(14(16)15)9-12(18)13-7-4-8-19-13/h2-8,15H,9H2,1H3
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210325
PNG
(3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboni...)
Show SMILES O=c1[nH]nc(-c2ccccc2)c(-c2ccccc2)c1C#N
Show InChI InChI=1S/C17H11N3O/c18-11-14-15(12-7-3-1-4-8-12)16(19-20-17(14)21)13-9-5-2-6-10-13/h1-10H,(H,20,21)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210323
PNG
(2-{[(4-chlorophenyl)sulfonyl]amino}benzamide | CHE...)
Show SMILES NC(=O)c1ccccc1NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O3S/c14-9-5-7-10(8-6-9)20(18,19)16-12-4-2-1-3-11(12)13(15)17/h1-8,16H,(H2,15,17)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210324
PNG
(6-phenylpteridin-4(3H)-one | CHEMBL228035)
Show SMILES O=c1[nH]cnc2ncc(nc12)-c1ccccc1
Show InChI InChI=1S/C12H8N4O/c17-12-10-11(14-7-15-12)13-6-9(16-10)8-4-2-1-3-5-8/h1-7H,(H,13,14,15,17)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210322
PNG
(CHEMBL374743 | N-[1-(2-pyrrolidin-1-ylethyl)-1H-be...)
Show SMILES CC(=O)Nc1nc2ccccc2n1CCN1CCCC1
Show InChI InChI=1S/C15H20N4O/c1-12(20)16-15-17-13-6-2-3-7-14(13)19(15)11-10-18-8-4-5-9-18/h2-3,6-7H,4-5,8-11H2,1H3,(H,16,17,20)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210321
PNG
(5-methoxy-2-piperidin-1-yl-1H-benzimidazole | CHEM...)
Show SMILES COc1ccc2nc([nH]c2c1)N1CCCCC1
Show InChI InChI=1S/C13H17N3O/c1-17-10-5-6-11-12(9-10)15-13(14-11)16-7-3-2-4-8-16/h5-6,9H,2-4,7-8H2,1H3,(H,14,15)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50210318
PNG
(6-chloro-4-hydroxy-2-oxo-N-1,3-thiazol-2-yl-2H-chr...)
Show SMILES Oc1c(C(=O)Nc2nccs2)c(=O)oc2ccc(Cl)cc12
Show InChI InChI=1S/C13H7ClN2O4S/c14-6-1-2-8-7(5-6)10(17)9(12(19)20-8)11(18)16-13-15-3-4-21-13/h1-5,17H,(H,15,16,18)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139707
PNG
(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-isoxa...)
Show SMILES [O-][N+](=O)c1c([n-][o+]c1C(F)(F)F)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H4F3N3O5/c11-10(12,13)9-8(16(19)20)7(14-21-9)5-1-3-6(4-2-5)15(17)18/h1-4H
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n/an/an/an/a>3.00E+4n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139710
PNG
(4-Nitro-3-phenyl-5-trifluoromethyl-1H-pyrazole | C...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C10H6F3N3O2/c11-10(12,13)9-8(16(17)18)7(14-15-9)6-4-2-1-3-5-6/h1-5H,(H,14,15)
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n/an/an/an/a 3.00E+4n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139708
PNG
(3-(4-Nitro-phenyl)-5-trifluoromethyl-1H-pyrazole |...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc([nH]n1)C(F)(F)F
Show InChI InChI=1S/C10H6F3N3O2/c11-10(12,13)9-5-8(14-15-9)6-1-3-7(4-2-6)16(17)18/h1-5H,(H,14,15)
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n/an/an/an/a>3.00E+4n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.066
BindingDB Entry DOI: 10.7270/Q29P312R
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 3.10E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119273
PNG
(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Show SMILES Nc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H14N4O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3,12H2,(H2,13,14,15)
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n/an/an/an/a 3.10E+4n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119273
PNG
(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Show SMILES Nc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H14N4O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3,12H2,(H2,13,14,15)
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n/an/an/an/a 3.20E+4n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)


Article DOI: 10.1016/s0960-894x(02)00617-0
BindingDB Entry DOI: 10.7270/Q20V8C4M
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 3.30E+4n/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 3.30E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)


Article DOI: 10.1021/jm061440p
BindingDB Entry DOI: 10.7270/Q2PK0FTT
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 6.96E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 286n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 7.40E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 1.94E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190500
PNG
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1
Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18)
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n/an/a 3.60E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190500
PNG
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1
Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18)
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n/an/a 81n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP


J Med Chem 49: 4127-39 (2006)


Article DOI: 10.1021/jm060042j
BindingDB Entry DOI: 10.7270/Q2B27TWN
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 320n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 1.65E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
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