Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with Target = 'Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50207690 (CHEMBL239512) Show SMILES CC(Cl)(Cl)[C@H](N\C(Nc1cccnc1)=N\C#N)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM86249 (ZD 6169 | ZD-6169) Show SMILES C[C@](O)(C(=O)Nc1ccc(cc1)C(=O)c1ccccc1)C(F)(F)F Show InChI InChI=1S/C17H14F3NO3/c1-16(24,17(18,19)20)15(23)21-13-9-7-12(8-10-13)14(22)11-5-3-2-4-6-11/h2-10,24H,1H3,(H,21,23)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208312 (CHEMBL421903) Show SMILES Clc1ccc(cc1)C(=O)NC(NC(=S)Nc1cccnc1)C(Cl)(Cl)Cl Show InChI InChI=1/C15H12Cl4N4OS/c16-10-5-3-9(4-6-10)12(24)22-13(15(17,18)19)23-14(25)21-11-2-1-7-20-8-11/h1-8,13H,(H,22,24)(H2,21,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	794	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208349 (CHEMBL128096) Show SMILES Clc1ccc(cc1)C(=O)NC(\N=C(/NC#N)Nc1cccnc1)C(Cl)(Cl)Cl Show InChI InChI=1/C16H12Cl4N6O/c17-11-5-3-10(4-6-11)13(27)25-14(16(18,19)20)26-15(23-9-21)24-12-2-1-7-22-8-12/h1-8,14H,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50209793 (CHEMBL335172) Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50211661 (CHEMBL128862) Show SMILES Cc1ccc(cc1)C(=O)NC(\N=C(/NC#N)Nc1cccnc1)C(C)(Cl)Cl Show InChI InChI=1/C18H18Cl2N6O/c1-12-5-7-13(8-6-12)15(27)25-16(18(2,19)20)26-17(23-11-21)24-14-4-3-9-22-10-14/h3-10,16H,1-2H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208313 (CHEMBL131347) Show SMILES CC(C)(C)C(N\C(S)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C18H21ClN4OS/c1-18(2,3)16(22-15(24)12-6-8-13(19)9-7-12)23-17(25)21-14-5-4-10-20-11-14/h4-11,16H,1-3H3,(H,22,24)(H2,21,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208352 (CHEMBL129080) Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1cccc(Cl)c1 Show InChI InChI=1/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-2-5-12(18)8-11)26-16(23-10-21)24-13-6-3-7-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50210172 (CHEMBL340330) Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1cccc(F)c1 Show InChI InChI=1/C17H15Cl2FN6O/c1-17(18,19)15(25-14(27)11-4-2-5-12(20)8-11)26-16(23-10-21)24-13-6-3-7-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208348 (CHEMBL339992) Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1cc(F)cc(F)c1 Show InChI InChI=1/C17H14Cl2F2N6O/c1-17(18,19)15(26-14(28)10-5-11(20)7-12(21)6-10)27-16(24-9-22)25-13-3-2-4-23-8-13/h2-8,15H,1H3,(H,26,28)(H2,24,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50207140 (CHEMBL131352) Show SMILES CCC(CC)(CCC#N)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C23H26ClN7O/c1-3-23(4-2,12-6-13-25)21(30-20(32)17-8-10-18(24)11-9-17)31-22(28-16-26)29-19-7-5-14-27-15-19/h5,7-11,14-15,21H,3-4,6,12H2,1-2H3,(H,30,32)(H2,28,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208350 (CHEMBL128062) Show SMILES Cc1cccc(c1)C(=O)NC(\N=C(/NC#N)Nc1cccnc1)C(C)(Cl)Cl Show InChI InChI=1/C18H18Cl2N6O/c1-12-5-3-6-13(9-12)15(27)25-16(18(2,19)20)26-17(23-11-21)24-14-7-4-8-22-10-14/h3-10,16H,1-2H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208424 (CHEMBL127164) Show SMILES CC(C)(C)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C19H21ClN6O/c1-19(2,3)17(25-16(27)13-6-8-14(20)9-7-13)26-18(23-12-21)24-15-5-4-10-22-11-15/h4-11,17H,1-3H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208316 (CHEMBL1788243) Show SMILES CC(Cl)(Cl)[C@@H](N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)/t15-/s2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50211663 (CHEMBL128831) Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Br)cc1 Show InChI InChI=1/C17H15BrCl2N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50207429 (CHEMBL130849) Show SMILES CC(C)(CC(NC(=O)c1ccc(Cl)cc1)N\C(NC#N)=N\c1cccnc1)C=C Show InChI InChI=1/C21H23ClN6O/c1-4-21(2,3)12-18(27-19(29)15-7-9-16(22)10-8-15)28-20(25-14-23)26-17-6-5-11-24-13-17/h4-11,13,18H,1,12H2,2-3H3,(H,27,29)(H2,25,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50210355 (CHEMBL132277) Show SMILES CC(C)(CC=C)C(NC(=O)c1ccc(Cl)cc1)N\C(NC#N)=N\c1cccnc1 Show InChI InChI=1/C21H23ClN6O/c1-4-11-21(2,3)19(27-18(29)15-7-9-16(22)10-8-15)28-20(25-14-23)26-17-6-5-12-24-13-17/h4-10,12-13,19H,1,11H2,2-3H3,(H,27,29)(H2,25,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50209291 (CHEMBL131453) Show SMILES CC(C)(C)C(N\C(N[N+]([O-])=O)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C18H21ClN6O3/c1-18(2,3)16(22-15(26)12-6-8-13(19)9-7-12)23-17(24-25(27)28)21-14-5-4-10-20-11-14/h4-11,16H,1-3H3,(H,22,26)(H2,21,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50211662 (CHEMBL131993) Show SMILES CC(C)(C)C(N\C(NS(N)(=O)=O)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C18H23ClN6O3S/c1-18(2,3)16(23-15(26)12-6-8-13(19)9-7-12)24-17(25-29(20,27)28)22-14-5-4-10-21-11-14/h4-11,16H,1-3H3,(H,23,26)(H2,20,27,28)(H2,22,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50210168 (CHEMBL130622) Show SMILES CN(C)S(=O)(=O)N\C(Nc1cccnc1)=N/C(NC(=O)c1ccc(Cl)cc1)C(C)(C)C Show InChI InChI=1/C20H27ClN6O3S/c1-20(2,3)18(24-17(28)14-8-10-15(21)11-9-14)25-19(26-31(29,30)27(4)5)23-16-7-6-12-22-13-16/h6-13,18H,1-5H3,(H,24,28)(H2,23,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50208351 (CHEMBL128767) Show SMILES CCCCC(C)(C)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C22H27ClN6O/c1-4-5-12-22(2,3)20(28-19(30)16-8-10-17(23)11-9-16)29-21(26-15-24)27-18-7-6-13-25-14-18/h6-11,13-14,20H,4-5,12H2,1-3H3,(H,28,30)(H2,26,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50210059 (CHEMBL127612) Show SMILES CC(C)(C)C(N\C(Nc1cccnc1)=C\[N+]([O-])=O)NC(=O)c1ccc(Cl)cc1 Show InChI InChI=1/C19H22ClN5O3/c1-19(2,3)18(24-17(26)13-6-8-14(20)9-7-13)23-16(12-25(27)28)22-15-5-4-10-21-11-15/h4-12,18,22-23H,1-3H3,(H,24,26)/b16-12+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B				Bioorg Med Chem Lett 14: 397-400 (2004) Article DOI: 10.1016/j.bmcl.2003.10.063 BindingDB Entry DOI: 10.7270/Q22V2J8T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062397 (3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...) Show SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1 Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062402 (1N-cyanoimino(tert-pentylamino)methyl-3-azido-4-io...) Show SMILES CCC(C)(C)NC(Nc1ccc(I)c(c1)N=[N+]=[N-])=NC#N Show InChI InChI=1S/C13H16IN7/c1-4-13(2,3)19-12(17-8-15)18-9-5-6-10(14)11(7-9)20-21-16/h5-7H,4H2,1-3H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062394 (1N-cyanoimino(tert-pentylamino)methyl-4-iodoanilin...) Show SMILES CCC(C)(C)NC(Nc1ccc(I)cc1)=NC#N Show InChI InChI=1S/C13H17IN4/c1-4-13(2,3)18-12(16-9-15)17-11-7-5-10(14)6-8-11/h5-8H,4H2,1-3H3,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	74	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062396 (4-cyanoimino(1,2,2-trimethylpropylamino)methylamin...) Show SMILES CC(NC(Nc1ccc(cc1)C#N)=NC#N)C(C)(C)C Show InChI InChI=1/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50012957 (1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...) Show SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1 Show InChI InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062398 (4-cyanoimino(tert-pentylamino)methylaminobenzonitr...) Show SMILES CCC(C)(C)NC(Nc1ccc(cc1)C#N)=NC#N Show InChI InChI=1S/C14H17N5/c1-4-14(2,3)19-13(17-10-16)18-12-7-5-11(9-15)6-8-12/h5-8H,4H2,1-3H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50240750 (()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylprop...) Show SMILES CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C Show InChI InChI=1/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062393 (3-cyanoimino(1,2,2-trimethylpropylamino)methylamin...) Show SMILES CC(NC(Nc1cccc(c1)C#N)=NC#N)C(C)(C)C Show InChI InChI=1/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-6-12(8-13)9-16/h5-8,11H,1-4H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062399 (4-[tert-butylamino(cyanoimino)methylamino]benzonit...) Show SMILES CC(C)(C)NC(Nc1ccc(cc1)C#N)=NC#N Show InChI InChI=1S/C13H15N5/c1-13(2,3)18-12(16-9-15)17-11-6-4-10(8-14)5-7-11/h4-7H,1-3H3,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062400 (1N-cyanoimino(1,2,2-trimethylpropylamino)methylani...) Show SMILES CC(NC(Nc1ccccc1)=NC#N)C(C)(C)C Show InChI InChI=1/C14H20N4/c1-11(14(2,3)4)17-13(16-10-15)18-12-8-6-5-7-9-12/h5-9,11H,1-4H3,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50044253 ((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...) Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N Show InChI InChI=1/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/s2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062392 (4-isopropylamino(cyanoimino)methylaminobenzonitril...) Show SMILES CC(C)NC(Nc1ccc(cc1)C#N)=NC#N Show InChI InChI=1S/C12H13N5/c1-9(2)16-12(15-8-14)17-11-5-3-10(7-13)4-6-11/h3-6,9H,1-2H3,(H2,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062395 (1N-cyanoimino(tert-pentylamino)methyl-3-hexahydro-...) Show SMILES CCC(C)(C)NC(Nc1cccc(c1)S(=O)(=O)N1CCCCC1)=NC#N Show InChI InChI=1S/C18H27N5O2S/c1-4-18(2,3)22-17(20-14-19)21-15-9-8-10-16(13-15)26(24,25)23-11-6-5-7-12-23/h8-10,13H,4-7,11-12H2,1-3H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062391 (1N-cyanoimino(tert-pentylamino)methyl-4-hexahydro-...) Show SMILES CCC(C)(C)NC(Nc1ccc(cc1)S(=O)(=O)N1CCCCC1)=NC#N Show InChI InChI=1S/C18H27N5O2S/c1-4-18(2,3)22-17(20-14-19)21-15-8-10-16(11-9-15)26(24,25)23-12-6-5-7-13-23/h8-11H,4-7,12-13H2,1-3H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50062401 (4-methylamino(cyanoimino)methylaminobenzonitrile |...) Show SMILES CNC(Nc1ccc(cc1)C#N)=NC#N Show InChI InChI=1S/C10H9N5/c1-13-10(14-7-12)15-9-4-2-8(6-11)3-5-9/h2-5H,1H3,(H2,13,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50044253 ((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...) Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N Show InChI InChI=1/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/s2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	7.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50099573 (1N-[4-methoxy-3-methylamino(thioxo)methylsulfamoyl...) Show SMILES CNC(=S)NS(=O)(=O)c1cc(CCNC(=O)c2cc(Cl)ccc2OC)ccc1OC Show InChI InChI=1S/C19H22ClN3O5S2/c1-21-19(29)23-30(25,26)17-10-12(4-6-16(17)28-3)8-9-22-18(24)14-11-13(20)5-7-15(14)27-2/h4-7,10-11H,8-9H2,1-3H3,(H,22,24)(H2,21,23,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes				J Med Chem 44: 1627-53 (2001) Article DOI: 10.1021/jm000484+ BindingDB Entry DOI: 10.7270/Q218376D
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50099576 (1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic...) Show SMILES CNC(=S)C1(CCC1)C(=O)c1ccc(cc1)-n1ccnc1 Show InChI InChI=1S/C16H17N3OS/c1-17-15(21)16(7-2-8-16)14(20)12-3-5-13(6-4-12)19-10-9-18-11-19/h3-6,9-11H,2,7-8H2,1H3,(H,17,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of SUR2B/Kir6.2				J Med Chem 44: 1627-53 (2001) Article DOI: 10.1021/jm000484+ BindingDB Entry DOI: 10.7270/Q218376D
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50012957 (1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...) Show SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1 Show InChI InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes				J Med Chem 44: 1627-53 (2001) Article DOI: 10.1021/jm000484+ BindingDB Entry DOI: 10.7270/Q218376D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50357207 (CHEMBL1915364 | CHEMBL1963307) Show SMILES OC(COc1ccc(F)cc1C(=O)CCc1ccccc1)CN1CCN(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1/C35H37FN2O3/c36-30-17-19-34(32(24-30)33(40)18-16-27-10-4-1-5-11-27)41-26-31(39)25-37-20-22-38(23-21-37)35(28-12-6-2-7-13-28)29-14-8-3-9-15-29/h1-15,17,19,24,31,35,39H,16,18,20-23,25-26H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay				J Med Chem 54: 7477-85 (2011) Article DOI: 10.1021/jm2005546 BindingDB Entry DOI: 10.7270/Q2SQ90T5
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50357205 (CHEMBL1914844 | CHEMBL1963594) Show SMILES Cc1ccc(cc1)N1CCN(CC(O)COc2ccccc2C(=O)CCc2ccccc2)CC1 Show InChI InChI=1/C29H34N2O3/c1-23-11-14-25(15-12-23)31-19-17-30(18-20-31)21-26(32)22-34-29-10-6-5-9-27(29)28(33)16-13-24-7-3-2-4-8-24/h2-12,14-15,26,32H,13,16-22H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay				J Med Chem 54: 7477-85 (2011) Article DOI: 10.1021/jm2005546 BindingDB Entry DOI: 10.7270/Q2SQ90T5
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50067133 (1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...) Show SMILES CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1 Show InChI InChI=1/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay				J Med Chem 54: 7477-85 (2011) Article DOI: 10.1021/jm2005546 BindingDB Entry DOI: 10.7270/Q2SQ90T5
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50099576 (1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic...) Show SMILES CNC(=S)C1(CCC1)C(=O)c1ccc(cc1)-n1ccnc1 Show InChI InChI=1S/C16H17N3OS/c1-17-15(21)16(7-2-8-16)14(20)12-3-5-13(6-4-12)19-10-9-18-11-19/h3-6,9-11H,2,7-8H2,1H3,(H,17,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of SUR2B/Kir6.2				J Med Chem 44: 1627-53 (2001) Article DOI: 10.1021/jm000484+ BindingDB Entry DOI: 10.7270/Q218376D
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 (Homo sapiens (Human))	BDBM50357204 (CHEMBL1914835 | CHEMBL1963280) Show SMILES OC(COc1ccccc1C(=O)CCc1ccccc1)CN1CCC(CC1)c1ccccc1 Show InChI InChI=1/C29H33NO3/c31-26(21-30-19-17-25(18-20-30)24-11-5-2-6-12-24)22-33-29-14-8-7-13-27(29)28(32)16-15-23-9-3-1-4-10-23/h1-14,25-26,31H,15-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay				J Med Chem 54: 7477-85 (2011) Article DOI: 10.1021/jm2005546 BindingDB Entry DOI: 10.7270/Q2SQ90T5
					More data for this Ligand-Target Pair