Found 225 hits Enz. Inhib. hit(s) with Target = 'Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476002
 (CHEMBL217511)Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,21H,4-6H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 0.676 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475970
 (CHEMBL426334)Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 0.912 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475995
 (CHEMBL218564)Show SMILES CCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475999
 (CHEMBL214561)Show SMILES CC[C@@H]1CC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO3/c1-2-9-6-14(23)18-16(10-3-4-12(21)11(20)5-10)17-13(22-19(9)18)7-25-8-15(17)24/h3-5,9,16,23H,2,6-8H2,1H3/t9-,16-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475981
 (CHEMBL413532)Show SMILES C[C@H]1OCC(=O)C2=C1N=C1COC(O)=C1[C@@H]2c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(12(21)6-23-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-24-17(14)22/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475993
 (CHEMBL217810)Show SMILES C[C@@H]1N(C)C(=O)C2=C1NC1COCC(=O)C1[C@H]2c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H18BrFN2O3/c1-8-17-16(18(24)22(8)2)14(9-3-4-11(20)10(19)5-9)15-12(21-17)6-25-7-13(15)23/h3-5,8,12,14-15,21H,6-7H2,1-2H3/t8-,12?,14+,15?/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475995
 (CHEMBL218564)Show SMILES CCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475953
 (CHEMBL384564)Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475995
 (CHEMBL218564)Show SMILES CCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475970
 (CHEMBL426334)Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476020
 (CHEMBL217847)Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-2-11-15-14(17(22)24-11)12(7-3-4-9(19)8(18)5-7)13-10(20-15)6-23-16(13)21/h3-5,11-12,22H,2,6H2,1H3/t11-,12+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475971
 (CHEMBL386363)Show SMILES COC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO5/c1-24-7-13-17-16(18(23)26-13)14(8-2-3-10(20)9(19)4-8)15-11(21-17)5-25-6-12(15)22/h2-4,13-14,23H,5-7H2,1H3/t13-,14+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475997
 (CHEMBL386119)Show SMILES CC[C@@H]1OCC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-11(21)10(20)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475973
 (CHEMBL265269)Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COC(C)(C)C3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C20H19BrFNO4/c1-4-13-17-16(19(25)27-13)14(9-5-6-11(22)10(21)7-9)15-12(23-17)8-26-20(2,3)18(15)24/h5-7,13-14,25H,4,8H2,1-3H3/t13-,14+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475983
 (CHEMBL216766)Show SMILES CC1(C)OCC2=NC3=C(C(C2=C1O)c1ccc(F)c(Br)c1)C(=O)COC3 Show InChI InChI=1S/C19H17BrFNO4/c1-19(2)18(24)17-13(7-26-19)22-12-6-25-8-14(23)16(12)15(17)9-3-4-11(21)10(20)5-9/h3-5,15,24H,6-8H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476011
 (CHEMBL216284)Show SMILES CC[C@H]1OCC(=O)C2=C1N=C1COC(O)=C1[C@@H]2c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(12(22)7-24-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-25-18(15)23/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475982
 (CHEMBL215375)Show SMILES CC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475997
 (CHEMBL386119)Show SMILES CC[C@@H]1OCC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-11(21)10(20)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50062397
 (3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475972
 (CHEMBL216546)Show SMILES COC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO5/c1-24-7-13-17-16(18(23)26-13)14(8-2-3-10(20)9(19)4-8)15-11(21-17)5-25-6-12(15)22/h2-4,13-14,23H,5-7H2,1H3/t13-,14-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475972
 (CHEMBL216546)Show SMILES COC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO5/c1-24-7-13-17-16(18(23)26-13)14(8-2-3-10(20)9(19)4-8)15-11(21-17)5-25-6-12(15)22/h2-4,13-14,23H,5-7H2,1H3/t13-,14-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475977
 (CHEMBL386582)Show SMILES CC1(C)OCC2=C(C(C3=C(O)OCC3=N2)c2ccc(F)c(Br)c2)C1=O Show InChI InChI=1S/C18H15BrFNO4/c1-18(2)16(22)14-12(7-25-18)21-11-6-24-17(23)15(11)13(14)8-3-4-10(20)9(19)5-8/h3-5,13,23H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475977
 (CHEMBL386582)Show SMILES CC1(C)OCC2=C(C(C3=C(O)OCC3=N2)c2ccc(F)c(Br)c2)C1=O Show InChI InChI=1S/C18H15BrFNO4/c1-18(2)16(22)14-12(7-25-18)21-11-6-24-17(23)15(11)13(14)8-3-4-10(20)9(19)5-8/h3-5,13,23H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476013
 (CHEMBL261996)Show SMILES CC1(C)OC(O)=C2C(C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO4/c1-18(2)16-15(17(23)25-18)13(8-3-4-10(20)9(19)5-8)14-11(21-16)6-24-7-12(14)22/h3-5,13,23H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476003
 (CHEMBL426160)Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(I)c1 Show InChI InChI=1S/C19H17FINO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-10(20)11(21)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475961
 (CHEMBL214841)Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475966
 (CHEMBL384576)Show SMILES CC(C)C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C20H19BrFNO4/c1-9(2)5-15-19-18(20(25)27-15)16(10-3-4-12(22)11(21)6-10)17-13(23-19)7-26-8-14(17)24/h3-4,6,9,15-16,25H,5,7-8H2,1-2H3/t15-,16+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475991
 (CHEMBL320983)Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2COC1)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c18-9-3-8(1-2-10(9)19)15-16-11(4-23-6-13(16)21)20-12-5-24-7-14(22)17(12)15/h1-3,15,21H,4-7H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475961
 (CHEMBL214841)Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476004
 (CHEMBL386323)Show SMILES CCCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C20H19BrFNO4/c1-2-3-4-15-19-18(20(25)27-15)16(10-5-6-12(22)11(21)7-10)17-13(23-19)8-26-9-14(17)24/h5-7,15-16,25H,2-4,8-9H2,1H3/t15-,16+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475970
 (CHEMBL426334)Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusor |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50044253
 ((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475953
 (CHEMBL384564)Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476002
 (CHEMBL217511)Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,21H,4-6H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476002
 (CHEMBL217511)Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,21H,4-6H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475970
 (CHEMBL426334)Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 51 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50062397
 (3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475954
 (CHEMBL216256)Show SMILES CC[C@H]1OCC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H17Cl2NO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-10(20)11(21)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476014
 (CHEMBL3138600)Show SMILES C[C@@H]1OC(=O)C2=C1NC1=C([C@H]2c2ccc(F)c(Br)c2)S(=O)(=O)CCC1 Show InChI InChI=1S/C17H15BrFNO4S/c1-8-15-14(17(21)24-8)13(9-4-5-11(19)10(18)7-9)16-12(20-15)3-2-6-25(16,22)23/h4-5,7-8,13,20H,2-3,6H2,1H3/t8-,13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476010
 (CHEMBL412838)Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(CCCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C19H17BrFNO3/c1-2-14-18-17(19(24)25-14)15(9-6-7-11(21)10(20)8-9)16-12(22-18)4-3-5-13(16)23/h6-8,14-15,24H,2-5H2,1H3/t14-,15+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475992
 (CHEMBL2112487)Show SMILES Fc1ccc(cc1Br)[C@H]1C2=C(COC2=O)NC2=C1C(=O)COC2 Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,19H,4-6H2/t13-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476000
 (CHEMBL215996)Show SMILES C[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475959
 (CHEMBL214566)Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H17ClFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 68 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475987
 (CHEMBL386126)Show SMILES C[C@@H]1OCC2=C([C@@H](C3=C(O)OCC3=N2)c2ccc(F)c(Br)c2)C1=O Show InChI InChI=1S/C17H13BrFNO4/c1-7-16(21)14-11(5-23-7)20-12-6-24-17(22)15(12)13(14)8-2-3-10(19)9(18)4-8/h2-4,7,13,22H,5-6H2,1H3/t7-,13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 72 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475958
 (CHEMBL424726)Show SMILES CC[C@H]1OC(O)=C2[C@@H](C3=C(COC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-2-11-15-14(17(22)24-11)12(7-3-4-9(19)8(18)5-7)13-10(20-15)6-23-16(13)21/h3-5,11-12,22H,2,6H2,1H3/t11-,12-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 72 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476003
 (CHEMBL426160)Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(I)c1 Show InChI InChI=1S/C19H17FINO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-10(20)11(21)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 76 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50062397
 (3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 85 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusor |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475959
 (CHEMBL214566)Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H17ClFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 91 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50475982
 (CHEMBL215375)Show SMILES CC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 95 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2
(Homo sapiens (Human)) | BDBM50476005
 (CHEMBL385908)Show SMILES C[C@@H]1OCC(=O)C2=C1N=C1COC(O)=C1[C@@H]2c1ccc(F)c(Br)c1 Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(12(21)6-23-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-24-17(14)22/h2-4,7,13,22H,5-6H2,1H3/t7-,13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 102 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay |
J Med Chem 49: 6869-87 (2006)
Article DOI: 10.1021/jm060549u BindingDB Entry DOI: 10.7270/Q2X069S9 |
More data for this Ligand-Target Pair | |