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Compile Data Set for Download or QSAR

Found 225 hits Enz. Inhib. hit(s) with Target = 'Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476002
PNG
(CHEMBL217511)
Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,21H,4-6H2
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n/an/an/an/a 0.676n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475970
PNG
(CHEMBL426334)
Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1
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n/an/an/an/a 0.912n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475995
PNG
(CHEMBL218564)
Show SMILES CCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15+/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475999
PNG
(CHEMBL214561)
Show SMILES CC[C@@H]1CC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO3/c1-2-9-6-14(23)18-16(10-3-4-12(21)11(20)5-10)17-13(22-19(9)18)7-25-8-15(17)24/h3-5,9,16,23H,2,6-8H2,1H3/t9-,16-/m1/s1
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n/an/an/an/a 1.20n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475981
PNG
(CHEMBL413532)
Show SMILES C[C@H]1OCC(=O)C2=C1N=C1COC(O)=C1[C@@H]2c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(12(21)6-23-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-24-17(14)22/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m1/s1
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n/an/an/an/a 1.80n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475993
PNG
(CHEMBL217810)
Show SMILES C[C@@H]1N(C)C(=O)C2=C1NC1COCC(=O)C1[C@H]2c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H18BrFN2O3/c1-8-17-16(18(24)22(8)2)14(9-3-4-11(20)10(19)5-9)15-12(21-17)6-25-7-13(15)23/h3-5,8,12,14-15,21H,6-7H2,1-2H3/t8-,12?,14+,15?/m0/s1
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n/an/an/an/a 2.80n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475995
PNG
(CHEMBL218564)
Show SMILES CCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15+/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475953
PNG
(CHEMBL384564)
Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14+/m0/s1
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n/an/an/an/a 3.90n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475995
PNG
(CHEMBL218564)
Show SMILES CCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15+/m0/s1
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n/an/an/an/a 5.10n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475970
PNG
(CHEMBL426334)
Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1
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n/an/an/an/a 5.5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476020
PNG
(CHEMBL217847)
Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-2-11-15-14(17(22)24-11)12(7-3-4-9(19)8(18)5-7)13-10(20-15)6-23-16(13)21/h3-5,11-12,22H,2,6H2,1H3/t11-,12+/m0/s1
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n/an/an/an/a 6n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475971
PNG
(CHEMBL386363)
Show SMILES COC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO5/c1-24-7-13-17-16(18(23)26-13)14(8-2-3-10(20)9(19)4-8)15-11(21-17)5-25-6-12(15)22/h2-4,13-14,23H,5-7H2,1H3/t13-,14+/m0/s1
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n/an/an/an/a 9.80n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475997
PNG
(CHEMBL386119)
Show SMILES CC[C@@H]1OCC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-11(21)10(20)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16+/m0/s1
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n/an/an/an/a 14n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475973
PNG
(CHEMBL265269)
Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COC(C)(C)C3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C20H19BrFNO4/c1-4-13-17-16(19(25)27-13)14(9-5-6-11(22)10(21)7-9)15-12(23-17)8-26-20(2,3)18(15)24/h5-7,13-14,25H,4,8H2,1-3H3/t13-,14+/m0/s1
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n/an/an/an/a 14n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475983
PNG
(CHEMBL216766)
Show SMILES CC1(C)OCC2=NC3=C(C(C2=C1O)c1ccc(F)c(Br)c1)C(=O)COC3
Show InChI InChI=1S/C19H17BrFNO4/c1-19(2)18(24)17-13(7-26-19)22-12-6-25-8-14(23)16(12)15(17)9-3-4-11(21)10(20)5-9/h3-5,15,24H,6-8H2,1-2H3
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n/an/an/an/a 17n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476011
PNG
(CHEMBL216284)
Show SMILES CC[C@H]1OCC(=O)C2=C1N=C1COC(O)=C1[C@@H]2c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(12(22)7-24-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-25-18(15)23/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14+/m1/s1
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n/an/an/an/a 18n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475982
PNG
(CHEMBL215375)
Show SMILES CC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14-/m1/s1
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n/an/an/an/a 19n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475997
PNG
(CHEMBL386119)
Show SMILES CC[C@@H]1OCC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-11(21)10(20)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16+/m0/s1
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n/an/an/an/a 20n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50062397
PNG
(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Show SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
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PubMed
n/an/an/an/a 22n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475972
PNG
(CHEMBL216546)
Show SMILES COC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO5/c1-24-7-13-17-16(18(23)26-13)14(8-2-3-10(20)9(19)4-8)15-11(21-17)5-25-6-12(15)22/h2-4,13-14,23H,5-7H2,1H3/t13-,14-/m1/s1
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n/an/an/an/a 23n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475972
PNG
(CHEMBL216546)
Show SMILES COC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO5/c1-24-7-13-17-16(18(23)26-13)14(8-2-3-10(20)9(19)4-8)15-11(21-17)5-25-6-12(15)22/h2-4,13-14,23H,5-7H2,1H3/t13-,14-/m1/s1
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n/an/an/an/a 23n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475977
PNG
(CHEMBL386582)
Show SMILES CC1(C)OCC2=C(C(C3=C(O)OCC3=N2)c2ccc(F)c(Br)c2)C1=O
Show InChI InChI=1S/C18H15BrFNO4/c1-18(2)16(22)14-12(7-25-18)21-11-6-24-17(23)15(11)13(14)8-3-4-10(20)9(19)5-8/h3-5,13,23H,6-7H2,1-2H3
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n/an/an/an/a 24n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475977
PNG
(CHEMBL386582)
Show SMILES CC1(C)OCC2=C(C(C3=C(O)OCC3=N2)c2ccc(F)c(Br)c2)C1=O
Show InChI InChI=1S/C18H15BrFNO4/c1-18(2)16(22)14-12(7-25-18)21-11-6-24-17(23)15(11)13(14)8-3-4-10(20)9(19)5-8/h3-5,13,23H,6-7H2,1-2H3
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n/an/an/an/a 27n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476013
PNG
(CHEMBL261996)
Show SMILES CC1(C)OC(O)=C2C(C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO4/c1-18(2)16-15(17(23)25-18)13(8-3-4-10(20)9(19)5-8)14-11(21-16)6-24-7-12(14)22/h3-5,13,23H,6-7H2,1-2H3
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n/an/an/an/a 27n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476003
PNG
(CHEMBL426160)
Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(I)c1
Show InChI InChI=1S/C19H17FINO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-10(20)11(21)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 27n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475961
PNG
(CHEMBL214841)
Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 28n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475966
PNG
(CHEMBL384576)
Show SMILES CC(C)C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C20H19BrFNO4/c1-9(2)5-15-19-18(20(25)27-15)16(10-3-4-12(22)11(21)6-10)17-13(23-19)7-26-8-14(17)24/h3-4,6,9,15-16,25H,5,7-8H2,1-2H3/t15-,16+/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475991
PNG
(CHEMBL320983)
Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2COC1)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c18-9-3-8(1-2-10(9)19)15-16-11(4-23-6-13(16)21)20-12-5-24-7-14(22)17(12)15/h1-3,15,21H,4-7H2
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n/an/an/an/a 28n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475961
PNG
(CHEMBL214841)
Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 29n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476004
PNG
(CHEMBL386323)
Show SMILES CCCC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C20H19BrFNO4/c1-2-3-4-15-19-18(20(25)27-15)16(10-5-6-12(22)11(21)7-10)17-13(23-19)8-26-9-14(17)24/h5-7,15-16,25H,2-4,8-9H2,1H3/t15-,16+/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475970
PNG
(CHEMBL426334)
Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1
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n/an/an/an/a 35n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusor


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50044253
PNG
((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1
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n/an/an/an/a 35n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475953
PNG
(CHEMBL384564)
Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14+/m0/s1
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n/an/an/an/a 35n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476002
PNG
(CHEMBL217511)
Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,21H,4-6H2
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n/an/an/an/a 37n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476002
PNG
(CHEMBL217511)
Show SMILES OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,21H,4-6H2
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n/an/an/an/a 46n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475970
PNG
(CHEMBL426334)
Show SMILES C[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13+/m0/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50062397
PNG
(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Show SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
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n/an/an/an/a 52n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475954
PNG
(CHEMBL216256)
Show SMILES CC[C@H]1OCC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H17Cl2NO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-10(20)11(21)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476014
PNG
(CHEMBL3138600)
Show SMILES C[C@@H]1OC(=O)C2=C1NC1=C([C@H]2c2ccc(F)c(Br)c2)S(=O)(=O)CCC1
Show InChI InChI=1S/C17H15BrFNO4S/c1-8-15-14(17(21)24-8)13(9-4-5-11(19)10(18)7-9)16-12(20-15)3-2-6-25(16,22)23/h4-5,7-8,13,20H,2-3,6H2,1H3/t8-,13-/m0/s1
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n/an/an/an/a 56n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476010
PNG
(CHEMBL412838)
Show SMILES CC[C@@H]1OC(O)=C2[C@@H](C3=C(CCCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C19H17BrFNO3/c1-2-14-18-17(19(24)25-14)15(9-6-7-11(21)10(20)8-9)16-12(22-18)4-3-5-13(16)23/h6-8,14-15,24H,2-5H2,1H3/t14-,15+/m0/s1
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n/an/an/an/a 56n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475992
PNG
(CHEMBL2112487)
Show SMILES Fc1ccc(cc1Br)[C@H]1C2=C(COC2=O)NC2=C1C(=O)COC2
Show InChI InChI=1S/C16H11BrFNO4/c17-8-3-7(1-2-9(8)18)13-14-10(4-22-6-12(14)20)19-11-5-23-16(21)15(11)13/h1-3,13,19H,4-6H2/t13-/m1/s1
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n/an/an/an/a 63n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476000
PNG
(CHEMBL215996)
Show SMILES C[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(17(22)24-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-23-6-12(14)21/h2-4,7,13,22H,5-6H2,1H3/t7-,13-/m1/s1
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n/an/an/an/a 65n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475959
PNG
(CHEMBL214566)
Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C19H17ClFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 68n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475987
PNG
(CHEMBL386126)
Show SMILES C[C@@H]1OCC2=C([C@@H](C3=C(O)OCC3=N2)c2ccc(F)c(Br)c2)C1=O
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16(21)14-11(5-23-7)20-12-6-24-17(22)15(12)13(14)8-2-3-10(19)9(18)4-8/h2-4,7,13,22H,5-6H2,1H3/t7-,13-/m0/s1
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n/an/an/an/a 72n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475958
PNG
(CHEMBL424726)
Show SMILES CC[C@H]1OC(O)=C2[C@@H](C3=C(COC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-2-11-15-14(17(22)24-11)12(7-3-4-9(19)8(18)5-7)13-10(20-15)6-23-16(13)21/h3-5,11-12,22H,2,6H2,1H3/t11-,12-/m1/s1
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n/an/an/an/a 72n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476003
PNG
(CHEMBL426160)
Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(I)c1
Show InChI InChI=1S/C19H17FINO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-10(20)11(21)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 76n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50062397
PNG
(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Show SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
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n/an/an/an/a 85n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusor


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475959
PNG
(CHEMBL214566)
Show SMILES CCC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C19H17ClFNO4/c1-2-3-14-18-17(19(24)26-14)15(9-4-5-11(21)10(20)6-9)16-12(22-18)7-25-8-13(16)23/h4-6,14-15,24H,2-3,7-8H2,1H3/t14-,15-/m1/s1
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n/an/an/an/a 91n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50475982
PNG
(CHEMBL215375)
Show SMILES CC[C@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1
Show InChI InChI=1S/C18H15BrFNO4/c1-2-13-17-16(18(23)25-13)14(8-3-4-10(20)9(19)5-8)15-11(21-17)6-24-7-12(15)22/h3-5,13-14,23H,2,6-7H2,1H3/t13-,14-/m1/s1
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n/an/an/an/a 95n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens (Human))
BDBM50476005
PNG
(CHEMBL385908)
Show SMILES C[C@@H]1OCC(=O)C2=C1N=C1COC(O)=C1[C@@H]2c1ccc(F)c(Br)c1
Show InChI InChI=1S/C17H13BrFNO4/c1-7-16-15(12(21)6-23-7)13(8-2-3-10(19)9(18)4-8)14-11(20-16)5-24-17(14)22/h2-4,7,13,22H,5-6H2,1H3/t7-,13-/m0/s1
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n/an/an/an/a 102n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay


J Med Chem 49: 6869-87 (2006)


Article DOI: 10.1021/jm060549u
BindingDB Entry DOI: 10.7270/Q2X069S9
More data for this
Ligand-Target Pair
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