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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily K member 18'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel subfamily K member 18


(Homo sapiens)
BDBM50197060
PNG
(CHEMBL1417584)
Show SMILES C1CCc2c(C1)cccc2Nc1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
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PC sid
UniChem

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Article
PubMed
n/an/an/an/a 6.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human TRESK channel relative to control


Bioorg Med Chem Lett 26: 4919-4924 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.020
BindingDB Entry DOI: 10.7270/Q2T72KDN
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 18


(Homo sapiens)
BDBM50197061
PNG
(CHEMBL3965023)
Show SMILES CC(C)(C)c1cccc(Nc2ccccc2-c2nnn[nH]2)c1
Show InChI InChI=1S/C17H19N5/c1-17(2,3)12-7-6-8-13(11-12)18-15-10-5-4-9-14(15)16-19-21-22-20-16/h4-11,18H,1-3H3,(H,19,20,21,22)
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UniChem

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Article
PubMed
n/an/an/an/a 1.88E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human TRESK channel expressed in HEK293 cells assessed as induction of channel current by whole cell patch clamp assay


Bioorg Med Chem Lett 26: 4919-4924 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.020
BindingDB Entry DOI: 10.7270/Q2T72KDN
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 18


(Homo sapiens)
BDBM50197058
PNG
(CHEMBL3970106)
Show SMILES CC(C)(C)c1cccc(Nc2ccccc2C(O)=O)c1
Show InChI InChI=1S/C17H19NO2/c1-17(2,3)12-7-6-8-13(11-12)18-15-10-5-4-9-14(15)16(19)20/h4-11,18H,1-3H3,(H,19,20)
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Article
PubMed
n/an/an/an/a 4.50E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human TRESK channel relative to control


Bioorg Med Chem Lett 26: 4919-4924 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.020
BindingDB Entry DOI: 10.7270/Q2T72KDN
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 18


(Homo sapiens)
BDBM17636
PNG
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
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CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


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Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human TRESK channel relative to control


Bioorg Med Chem Lett 26: 4919-4924 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.020
BindingDB Entry DOI: 10.7270/Q2T72KDN
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 18


(Homo sapiens)
BDBM17636
PNG
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
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KEGG
MMDB
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PC sid
PDB
UniChem

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Article
PubMed
n/an/an/an/a 4.74E+5n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human TRESK channel expressed in HEK293 cells assessed as induction of channel current by whole cell patch clamp assay


Bioorg Med Chem Lett 26: 4919-4924 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.020
BindingDB Entry DOI: 10.7270/Q2T72KDN
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 18


(Homo sapiens)
BDBM50017662
PNG
(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Show SMILES CCN(CC)CC(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
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CHEMBL
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KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Channel blocking activity at human TRESK channel


Bioorg Med Chem Lett 26: 4919-4924 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.020
BindingDB Entry DOI: 10.7270/Q2T72KDN
More data for this
Ligand-Target Pair