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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily K member 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel subfamily K member 4


(Homo sapiens (Human))
BDBM50514764
PNG
(CHEMBL4552751)
Show SMILES Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](C2)C(O)=O)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-12-2-9-17-18(10-12)27-20(23-17)13-5-7-16(8-6-13)22-19(24)14-3-4-15(11-14)21(25)26/h2,5-10,14-15H,3-4,11H2,1H3,(H,22,24)(H,25,26)/t14-,15+/m1/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.53E+4n/an/an/an/a



East China Normal University

Curated by ChEMBL


Assay Description
Activation of recombinant human TRAAK expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clamp electrophys...


J Med Chem 63: 3665-3677 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02163
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 4


(Homo sapiens (Human))
BDBM50180656
PNG
(CHEMBL3818503)
Show SMILES CC1(C)c2cc(Cl)ccc2N(CCc2nnn[nH]2)c2ccc(Cl)cc12
Show InChI InChI=1S/C18H17Cl2N5/c1-18(2)13-9-11(19)3-5-15(13)25(8-7-17-21-23-24-22-17)16-6-4-12(20)10-14(16)18/h3-6,9-10H,7-8H2,1-2H3,(H,21,22,23,24)
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Similars

Article
PubMed
n/an/an/an/a 2.70E+4n/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Activation of TRAAK (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents


J Med Chem 59: 5149-57 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00671
BindingDB Entry DOI: 10.7270/Q2319XSS
More data for this
Ligand-Target Pair