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Compile Data Set for Download or QSAR

Found 20 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily KQT member 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50465773
PNG
(CHEMBL4277250)
Show SMILES OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H22F5NO2/c23-21(24)10-9-17(14-5-2-1-3-6-14)18(12-21)20(30)28-19(13-29)15-7-4-8-16(11-15)22(25,26)27/h1-8,11,17-19,29H,9-10,12-13H2,(H,28,30)/t17-,18+,19+/m1/s1
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n/an/an/an/a 20n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50526876
PNG
(CHEMBL4457044)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1
Show InChI InChI=1S/C22H23F3N2O/c1-21(2,3)13-20(28)26-18-8-9-19-16(12-18)10-11-27(19)14-15-4-6-17(7-5-15)22(23,24)25/h4-12H,13-14H2,1-3H3,(H,26,28)
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n/an/an/an/a 80n/an/an/an/a



University Federico II of Naples

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay


J Med Chem 63: 163-185 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00796
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50526877
PNG
(CHEMBL4545892)
Show SMILES CCCCCCC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1
Show InChI InChI=1S/C23H25F3N2O/c1-2-3-4-5-6-22(29)27-20-11-12-21-18(15-20)13-14-28(21)16-17-7-9-19(10-8-17)23(24,25)26/h7-15H,2-6,16H2,1H3,(H,27,29)
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n/an/an/an/a 100n/an/an/an/a



University Federico II of Naples

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay


J Med Chem 63: 163-185 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00796
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50465774
PNG
(CHEMBL4287894)
Show SMILES OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H22ClF2NO2/c22-16-8-4-7-15(11-16)19(13-26)25-20(27)18-12-21(23,24)10-9-17(18)14-5-2-1-3-6-14/h1-8,11,17-19,26H,9-10,12-13H2,(H,25,27)/t17-,18+,19+/m1/s1
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50465777
PNG
(CHEMBL4288707)
Show SMILES C[C@H](NC(=O)c1cc(F)c(F)cc1Oc1ccccc1)c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C22H19F2NO4S/c1-14(15-7-6-10-17(11-15)30(2,27)28)25-22(26)18-12-19(23)20(24)13-21(18)29-16-8-4-3-5-9-16/h3-14H,1-2H3,(H,25,26)/t14-/m0/s1
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n/an/an/an/a 160n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4


(Rattus norvegicus)
BDBM50121051
PNG
(CHEMBL3621437)
Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23)
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n/an/an/an/a 376n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Activation of rat Kv7.4 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50121051
PNG
(CHEMBL3621437)
Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23)
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n/an/an/an/a 625n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50521289
PNG
(CHEMBL4588394)
Show SMILES CCOC(=O)Nc1ccc(cc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1
Show InChI InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-22(29)31-7-2)21(15-19)27-23(30)32-24(3,4)5/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,29)(H,27,30)
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n/an/an/an/a 780n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay


ACS Med Chem Lett 10: 27-33 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00315
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50521287
PNG
(CHEMBL4448132)
Show SMILES CCOC(=O)Nc1ccc(cc1NC(=O)OCC)N(CC#C)Cc1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4/c1-4-13-26(15-16-7-9-17(23)10-8-16)18-11-12-19(24-21(27)29-5-2)20(14-18)25-22(28)30-6-3/h1,7-12,14H,5-6,13,15H2,2-3H3,(H,24,27)(H,25,28)
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n/an/an/an/a 890n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Activation of human homomeric KCNQ4 expressed in CHOK1 cells at -10 mV by whole cell patch clamp assay


ACS Med Chem Lett 10: 27-33 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00315
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50521288
PNG
(CHEMBL4438770)
Show SMILES CCOC(=O)Nc1cc(ccc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1
Show InChI InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-23(30)32-24(3,4)5)21(15-19)27-22(29)31-7-2/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,30)(H,27,29)
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n/an/an/an/a 1.42E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay


ACS Med Chem Lett 10: 27-33 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00315
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50465775
PNG
(CHEMBL1703636)
Show SMILES Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1
Show InChI InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19)
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n/an/an/an/a 1.60E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50143558
PNG
(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Show SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N
Show InChI InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
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n/an/an/an/a 1.98E+3n/an/an/an/a



University Federico II of Naples

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay


J Med Chem 63: 163-185 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00796
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50521286
PNG
(CHEMBL4450214)
Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1
Show InChI InChI=1S/C26H32FN3O4/c1-8-15-30(17-18-9-11-19(27)12-10-18)20-13-14-21(28-23(31)33-25(2,3)4)22(16-20)29-24(32)34-26(5,6)7/h1,9-14,16H,15,17H2,2-7H3,(H,28,31)(H,29,32)
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n/an/an/an/a 2.03E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay


ACS Med Chem Lett 10: 27-33 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00315
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50426567
PNG
(BMS-204352 | FLINDOKALNER | MaxiPost)
Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50465778
PNG
(CHEMBL4287478)
Show SMILES C[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H23F2NO/c1-15(16-8-4-2-5-9-16)24-20(25)19-14-21(22,23)13-12-18(19)17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,24,25)/t15-,18+,19-/m0/s1
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n/an/an/an/a 4.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50143558
PNG
(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Show SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N
Show InChI InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
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n/an/an/an/a 5.90E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay


ACS Med Chem Lett 10: 27-33 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00315
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50420049
PNG
(CHEMBL402146)
Show SMILES Fc1ccc(cc1F)C(=O)Nc1ccc(Cl)nc1
Show InChI InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50465779
PNG
(CHEMBL4278049)
Show SMILES CS(=O)(=O)c1cccc(c1)[C@H](CO)NC(=O)c1cc(ccc1Oc1ccccc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C22H20F5NO5S2/c1-34(31,32)17-9-5-6-15(12-17)20(14-29)28-22(30)19-13-18(35(23,24,25,26)27)10-11-21(19)33-16-7-3-2-4-8-16/h2-13,20,29H,14H2,1H3,(H,28,30)/t20-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 by patch clamp method


Bioorg Med Chem Lett 28: 3793-3797 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390916
PNG
(CHEMBL2070953)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to c...


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ4 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair