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Compile Data Set for Download or QSAR

Found 207 hits Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 142'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437420
PNG
(CHEMBL2409014)
Show SMILES CCCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1cncn1CC(O)=O
Show InChI InChI=1S/C23H25N7O3S/c1-3-4-6-18-17(22(33)25-11-16-10-24-14-29(16)13-20(31)32)12-27-30(18)23-26-9-15(2)21(28-23)19-7-5-8-34-19/h5,7-10,12,14H,3-4,6,11,13H2,1-2H3,(H,25,33)(H,31,32)
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n/an/an/an/a 0.200n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437419
PNG
(CHEMBL2409009)
Show SMILES CCCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1cncn1C
Show InChI InChI=1S/C22H25N7OS/c1-4-5-7-18-17(21(30)24-12-16-11-23-14-28(16)3)13-26-29(18)22-25-10-15(2)20(27-22)19-8-6-9-31-19/h6,8-11,13-14H,4-5,7,12H2,1-3H3,(H,24,30)
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n/an/an/an/a 1n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437418
PNG
(CHEMBL2409011)
Show SMILES CCCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1c(C)ncn1C
Show InChI InChI=1S/C23H27N7OS/c1-5-6-8-18-17(22(31)24-13-19-16(3)26-14-29(19)4)12-27-30(18)23-25-11-15(2)21(28-23)20-9-7-10-32-20/h7,9-12,14H,5-6,8,13H2,1-4H3,(H,24,31)
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n/an/an/an/a 1n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437417
PNG
(CHEMBL2409019)
Show SMILES CCOCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1cncn1C
Show InChI InChI=1S/C21H23N7O2S/c1-4-30-12-17-16(20(29)23-10-15-9-22-13-27(15)3)11-25-28(17)21-24-8-14(2)19(26-21)18-6-5-7-31-18/h5-9,11,13H,4,10,12H2,1-3H3,(H,23,29)
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n/an/an/an/a 1.30n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50395776
PNG
(CHEMBL2164850)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC1(CC1)c1ccccn1
Show InChI InChI=1S/C27H25N5O2/c33-25-22(17-21(18-30-25)20-9-14-28-15-10-20)31-26(34)23(16-19-6-2-1-3-7-19)32-27(11-12-27)24-8-4-5-13-29-24/h1-10,13-15,17-18,23,32H,11-12,16H2,(H,30,33)(H,31,34)/t23-/m0/s1
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n/an/an/an/a 1.80n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay


Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201572
PNG
(CHEMBL3965469)
Show SMILES Cc1nccn1-c1ccc(cn1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C19H15Cl2N7O/c1-12-22-7-8-28(12)17-6-5-13(9-23-17)16-10-27(26-25-16)11-18(29)24-15-4-2-3-14(20)19(15)21/h2-10H,11H2,1H3,(H,24,29)
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n/an/an/an/a 2n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201607
PNG
(CHEMBL3905835)
Show SMILES Cc1nccn1-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-23-9-10-28(13)15-7-5-14(6-8-15)18-11-27(26-25-18)12-19(29)24-17-4-2-3-16(21)20(17)22/h2-11H,12H2,1H3,(H,24,29)
KEGG

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n/an/an/an/a 3n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201604
PNG
(CHEMBL3976574)
Show SMILES Clc1cccc(NC(=O)Cn2cc(nn2)-c2ccc(cc2)-n2ccnc2)c1Cl
Show InChI InChI=1S/C19H14Cl2N6O/c20-15-2-1-3-16(19(15)21)23-18(28)11-27-10-17(24-25-27)13-4-6-14(7-5-13)26-9-8-22-12-26/h1-10,12H,11H2,(H,23,28)
KEGG

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n/an/an/an/a 3n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437416
PNG
(CHEMBL2409031)
Show SMILES CCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NC(C)(C)c1ccncc1
Show InChI InChI=1S/C24H26N6OS/c1-5-7-19-18(22(31)29-24(3,4)17-9-11-25-12-10-17)15-27-30(19)23-26-14-16(2)21(28-23)20-8-6-13-32-20/h6,8-15H,5,7H2,1-4H3,(H,29,31)
KEGG

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n/an/an/an/a 5n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437415
PNG
(CHEMBL2409027)
Show SMILES CCCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1ccncc1
Show InChI InChI=1S/C23H24N6OS/c1-3-4-6-19-18(22(30)25-14-17-8-10-24-11-9-17)15-27-29(19)23-26-13-16(2)21(28-23)20-7-5-12-31-20/h5,7-13,15H,3-4,6,14H2,1-2H3,(H,25,30)
KEGG

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n/an/an/an/a 7n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201572
PNG
(CHEMBL3965469)
Show SMILES Cc1nccn1-c1ccc(cn1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C19H15Cl2N7O/c1-12-22-7-8-28(12)17-6-5-13(9-23-17)16-10-27(26-25-16)11-18(29)24-15-4-2-3-14(20)19(15)21/h2-10H,11H2,1H3,(H,24,29)
KEGG

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n/an/an/an/a 8n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201575
PNG
(CHEMBL3903475)
Show SMILES Cc1cn(cn1)-c1ccc(cc1F)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)18-6-5-13(7-15(18)23)17-9-29(27-26-17)10-19(30)25-16-4-2-3-14(21)20(16)22/h2-9,11H,10H2,1H3,(H,25,30)
KEGG

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n/an/an/an/a 9n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544800
PNG
(CHEMBL4647745)
Show SMILES CN([C@@H]1CCC[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(c1)C(F)(F)F
KEGG

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n/an/an/an/a 11n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201577
PNG
(CHEMBL3967871)
Show SMILES Cc1cn(cn1)-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-9-27(12-23-13)15-7-5-14(6-8-15)18-10-28(26-25-18)11-19(29)24-17-4-2-3-16(21)20(17)22/h2-10,12H,11H2,1H3,(H,24,29)
KEGG

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n/an/an/an/a 12n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201607
PNG
(CHEMBL3905835)
Show SMILES Cc1nccn1-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-23-9-10-28(13)15-7-5-14(6-8-15)18-11-27(26-25-18)12-19(29)24-17-4-2-3-16(21)20(17)22/h2-11H,12H2,1H3,(H,24,29)
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n/an/an/an/a 12n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437414
PNG
(CHEMBL2409023)
Show SMILES CCOCc1c(cnn1-c1ncc(C)c(n1)N1CCCC1)C(=O)NCc1cncn1C
Show InChI InChI=1S/C21H28N8O2/c1-4-31-13-18-17(20(30)23-11-16-10-22-14-27(16)3)12-25-29(18)21-24-9-15(2)19(26-21)28-7-5-6-8-28/h9-10,12,14H,4-8,11,13H2,1-3H3,(H,23,30)
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n/an/an/an/a 14n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544805
PNG
(CHEMBL4646017)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1CC1CC1)C(=O)c1cccc(c1)C(F)(F)F
KEGG

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n/an/an/an/a 14n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544801
PNG
(CHEMBL4647456)
Show SMILES CN([C@@H]1CCC[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(Cl)c1
KEGG

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n/an/an/an/a 14n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201577
PNG
(CHEMBL3967871)
Show SMILES Cc1cn(cn1)-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-9-27(12-23-13)15-7-5-14(6-8-15)18-10-28(26-25-18)11-19(29)24-17-4-2-3-16(21)20(17)22/h2-10,12H,11H2,1H3,(H,24,29)
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n/an/an/an/a 14n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201604
PNG
(CHEMBL3976574)
Show SMILES Clc1cccc(NC(=O)Cn2cc(nn2)-c2ccc(cc2)-n2ccnc2)c1Cl
Show InChI InChI=1S/C19H14Cl2N6O/c20-15-2-1-3-16(19(15)21)23-18(28)11-27-10-17(24-25-27)13-4-6-14(7-5-13)26-9-8-22-12-26/h1-10,12H,11H2,(H,23,28)
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n/an/an/an/a 16n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544804
PNG
(CHEMBL4637374)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C1CCC1)C(=O)c1cccc(c1)C(F)(F)F
KEGG

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n/an/an/an/a 16n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201604
PNG
(CHEMBL3976574)
Show SMILES Clc1cccc(NC(=O)Cn2cc(nn2)-c2ccc(cc2)-n2ccnc2)c1Cl
Show InChI InChI=1S/C19H14Cl2N6O/c20-15-2-1-3-16(19(15)21)23-18(28)11-27-10-17(24-25-27)13-4-6-14(7-5-13)26-9-8-22-12-26/h1-10,12H,11H2,(H,23,28)
KEGG

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n/an/an/an/a 18n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201577
PNG
(CHEMBL3967871)
Show SMILES Cc1cn(cn1)-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-9-27(12-23-13)15-7-5-14(6-8-15)18-10-28(26-25-18)11-19(29)24-17-4-2-3-16(21)20(17)22/h2-10,12H,11H2,1H3,(H,24,29)
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n/an/an/an/a 19n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201606
PNG
(CHEMBL3896713)
Show SMILES Cc1cn(cn1)-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)c(F)c1
Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)13-5-6-14(16(23)7-13)18-9-29(27-26-18)10-19(30)25-17-4-2-3-15(21)20(17)22/h2-9,11H,10H2,1H3,(H,25,30)
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n/an/an/an/a 19n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437413
PNG
(CHEMBL2409007)
Show SMILES CCOCc1c(cnn1-c1ncc(C)c(n1)N1CCCCC1)C(=O)NCc1cncn1C
Show InChI InChI=1S/C22H30N8O2/c1-4-32-14-19-18(21(31)24-12-17-11-23-15-28(17)3)13-26-30(19)22-25-10-16(2)20(27-22)29-8-6-5-7-9-29/h10-11,13,15H,4-9,12,14H2,1-3H3,(H,24,31)
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n/an/an/an/a 22n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50381477
PNG
(CHEMBL2017410)
Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1
Show InChI InChI=1S/C25H22N6O2/c1-17-13-30(16-26-17)23-11-10-19(12-24(23)33-2)22-14-31(29-28-22)15-25(32)27-21-9-5-7-18-6-3-4-8-20(18)21/h3-14,16H,15H2,1-2H3,(H,27,32)
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n/an/an/an/a 23n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201572
PNG
(CHEMBL3965469)
Show SMILES Cc1nccn1-c1ccc(cn1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C19H15Cl2N7O/c1-12-22-7-8-28(12)17-6-5-13(9-23-17)16-10-27(26-25-16)11-18(29)24-15-4-2-3-14(20)19(15)21/h2-10H,11H2,1H3,(H,24,29)
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n/an/an/an/a 24n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201572
PNG
(CHEMBL3965469)
Show SMILES Cc1nccn1-c1ccc(cn1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C19H15Cl2N7O/c1-12-22-7-8-28(12)17-6-5-13(9-23-17)16-10-27(26-25-16)11-18(29)24-15-4-2-3-14(20)19(15)21/h2-10H,11H2,1H3,(H,24,29)
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Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437412
PNG
(CHEMBL2409021)
Show SMILES CCOCc1c(cnn1-c1ncc(C)c(NC2CCC2)n1)C(=O)NCc1cncn1C
Show InChI InChI=1S/C21H28N8O2/c1-4-31-12-18-17(20(30)23-10-16-9-22-13-28(16)3)11-25-29(18)21-24-8-14(2)19(27-21)26-15-6-5-7-15/h8-9,11,13,15H,4-7,10,12H2,1-3H3,(H,23,30)(H,24,26,27)
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n/an/an/an/a 25n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201607
PNG
(CHEMBL3905835)
Show SMILES Cc1nccn1-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-23-9-10-28(13)15-7-5-14(6-8-15)18-11-27(26-25-18)12-19(29)24-17-4-2-3-16(21)20(17)22/h2-11H,12H2,1H3,(H,24,29)
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n/an/an/an/a 25n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50440696
PNG
(CHEMBL2430979)
Show SMILES CNc1cc(ccn1)-c1cc(NC(=O)[C@H](Cc2ccc(F)cc2)NCc2cnn[nH]2)n(C)n1
Show InChI InChI=1S/C22H24FN9O/c1-24-20-10-15(7-8-25-20)18-11-21(32(2)30-18)28-22(33)19(26-12-17-13-27-31-29-17)9-14-3-5-16(23)6-4-14/h3-8,10-11,13,19,26H,9,12H2,1-2H3,(H,24,25)(H,28,33)(H,27,29,31)/t19-/m0/s1
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n/an/an/an/a 26n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...


ACS Med Chem Lett 4: 829-34 (2013)


Article DOI: 10.1021/ml4000854
BindingDB Entry DOI: 10.7270/Q2JM2C20
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201604
PNG
(CHEMBL3976574)
Show SMILES Clc1cccc(NC(=O)Cn2cc(nn2)-c2ccc(cc2)-n2ccnc2)c1Cl
Show InChI InChI=1S/C19H14Cl2N6O/c20-15-2-1-3-16(19(15)21)23-18(28)11-27-10-17(24-25-27)13-4-6-14(7-5-13)26-9-8-22-12-26/h1-10,12H,11H2,(H,23,28)
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n/an/an/an/a 26n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM332764
PNG
(Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- i...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(Cl)c1
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n/an/an/an/a 27n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201607
PNG
(CHEMBL3905835)
Show SMILES Cc1nccn1-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-23-9-10-28(13)15-7-5-14(6-8-15)18-11-27(26-25-18)12-19(29)24-17-4-2-3-16(21)20(17)22/h2-11H,12H2,1H3,(H,24,29)
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n/an/an/an/a 27n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM332764
PNG
(Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- i...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(Cl)c1
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n/an/an/an/a 27.2n/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37 C. and 5% CO2. The c...


US Patent US10196385 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2JVR
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437411
PNG
(CHEMBL2409022)
Show SMILES CCOCc1c(cnn1-c1ncc(C)c(n1)N1CCC1)C(=O)NCc1cncn1C
Show InChI InChI=1S/C20H26N8O2/c1-4-30-12-17-16(19(29)22-10-15-9-21-13-26(15)3)11-24-28(17)20-23-8-14(2)18(25-20)27-6-5-7-27/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,22,29)
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n/an/an/an/a 28n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437410
PNG
(CHEMBL2409030)
Show SMILES CCOCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1ccncc1
Show InChI InChI=1S/C22H22N6O2S/c1-3-30-14-18-17(21(29)24-12-16-6-8-23-9-7-16)13-26-28(18)22-25-11-15(2)20(27-22)19-5-4-10-31-19/h4-11,13H,3,12,14H2,1-2H3,(H,24,29)
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n/an/an/an/a 30n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50437409
PNG
(CHEMBL2409012)
Show SMILES CCCCc1c(cnn1-c1ncc(C)c(n1)-c1cccs1)C(=O)NCc1cnc(C)n1C
Show InChI InChI=1S/C23H27N7OS/c1-5-6-8-19-18(22(31)25-13-17-12-24-16(3)29(17)4)14-27-30(19)23-26-11-15(2)21(28-23)20-9-7-10-32-20/h7,9-12,14H,5-6,8,13H2,1-4H3,(H,25,31)
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n/an/an/an/a 30n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay


ACS Med Chem Lett 4: 790-4 (2013)


Article DOI: 10.1021/ml400186z
BindingDB Entry DOI: 10.7270/Q24J0GHW
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM332763
PNG
(Cis-(chiral)-N-[2-[5-(1,4- Dimethyl-1H-imidazol-5-...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(OC(F)(F)F)c1
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n/an/an/an/a 30n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544789
PNG
(CHEMBL4647315)
Show SMILES CN([C@@H]1CCC[C@@H](C1)C(=O)Nc1c(C)ncn1C)C(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H25F3N4O2/c1-13-18(27(2)12-25-13)26-19(29)14-6-5-9-17(11-14)28(3)20(30)15-7-4-8-16(10-15)21(22,23)24/h4,7-8,10,12,14,17H,5-6,9,11H2,1-3H3,(H,26,29)/t14-,17+/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM332763
PNG
(Cis-(chiral)-N-[2-[5-(1,4- Dimethyl-1H-imidazol-5-...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(OC(F)(F)F)c1
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n/an/an/an/a 30.1n/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37 C. and 5% CO2. The c...


US Patent US10196385 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2JVR
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50440693
PNG
(CHEMBL2430983)
Show SMILES Cn1nc(cc1NC(=O)[C@H](Cc1ccccc1)NCC(O)=O)-c1ccncc1
Show InChI InChI=1S/C20H21N5O3/c1-25-18(12-16(24-25)15-7-9-21-10-8-15)23-20(28)17(22-13-19(26)27)11-14-5-3-2-4-6-14/h2-10,12,17,22H,11,13H2,1H3,(H,23,28)(H,26,27)/t17-/m0/s1
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n/an/an/an/a 31n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142


ACS Med Chem Lett 4: 829-34 (2013)


Article DOI: 10.1021/ml4000854
BindingDB Entry DOI: 10.7270/Q2JM2C20
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201575
PNG
(CHEMBL3903475)
Show SMILES Cc1cn(cn1)-c1ccc(cc1F)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)18-6-5-13(7-15(18)23)17-9-29(27-26-17)10-19(30)25-16-4-2-3-14(21)20(16)22/h2-9,11H,10H2,1H3,(H,25,30)
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n/an/an/an/a 32n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544807
PNG
(CHEMBL4641575)
Show SMILES CN([C@@H]1CCC[C@@H](C1)c1nnc([nH]1)-c1cnc2COCCn12)C(=O)c1cccc(c1)C(F)(F)F
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n/an/an/an/a 32n/an/an/an/a



Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50201577
PNG
(CHEMBL3967871)
Show SMILES Cc1cn(cn1)-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C20H16Cl2N6O/c1-13-9-27(12-23-13)15-7-5-14(6-8-15)18-10-28(26-25-18)11-19(29)24-17-4-2-3-16(21)20(17)22/h2-10,12H,11H2,1H3,(H,24,29)
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n/an/an/an/a 34n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50544810
PNG
(CHEMBL4641984)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1cnc2ccccn12)C(=O)c1cccc(Cl)c1
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Lilly China Research and Development Center (LCRDC)

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50201573
PNG
(CHEMBL3908606)
Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1
Show InChI InChI=1S/C21H18Cl2N6O2/c1-13-9-28(12-24-13)18-7-6-14(8-19(18)31-2)17-10-29(27-26-17)11-20(30)25-16-5-3-4-15(22)21(16)23/h3-10,12H,11H2,1-2H3,(H,25,30)
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n/an/an/an/a 36n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50395775
PNG
(CHEMBL2164857)
Show SMILES CNc1cc(ccn1)-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1
Show InChI InChI=1S/C21H21N7OS2/c1-22-18-10-15(7-8-23-18)20-27-28-21(31-20)26-19(29)17(9-14-5-3-2-4-6-14)24-11-16-12-30-13-25-16/h2-8,10,12-13,17,24H,9,11H2,1H3,(H,22,23)(H,26,28,29)/t17-/m0/s1
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n/an/an/an/a 36n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting


Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50381477
PNG
(CHEMBL2017410)
Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1
Show InChI InChI=1S/C25H22N6O2/c1-17-13-30(16-26-17)23-11-10-19(12-24(23)33-2)22-14-31(29-28-22)15-25(32)27-21-9-5-7-18-6-3-4-8-20(18)21/h3-14,16H,15H2,1-2H3,(H,27,32)
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n/an/an/an/a 37n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay


ACS Med Chem Lett 7: 1107-1111 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))
BDBM50440714
PNG
(CHEMBL2431062)
Show SMILES Cn1nc(cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1)-c1ccncc1
Show InChI InChI=1S/C22H22N6OS/c1-28-21(12-19(27-28)17-7-9-23-10-8-17)26-22(29)20(11-16-5-3-2-4-6-16)25-14-18-13-24-15-30-18/h2-10,12-13,15,20,25H,11,14H2,1H3,(H,26,29)/t20-/m0/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...


ACS Med Chem Lett 4: 829-34 (2013)


Article DOI: 10.1021/ml4000854
BindingDB Entry DOI: 10.7270/Q2JM2C20
More data for this
Ligand-Target Pair
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