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Compile Data Set for Download or QSAR

Found 188 hits Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 34'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 34


(Mus musculus)
BDBM50238935
PNG
(CHEMBL4062945)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C38H44NO10P/c1-38(2,3)31-17-12-28(13-18-31)29-14-19-32(20-15-29)49-33-10-6-8-27(24-33)25-46-35-11-5-4-9-30(35)16-21-36(40)45-22-7-23-47-50(43,44)48-26-34(39)37(41)42/h4-6,8-15,17-20,24,34H,7,16,21-23,25-26,39H2,1-3H3,(H,41,42)(H,43,44)/t34-/s2
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n/an/an/an/a 7.90n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238935
PNG
(CHEMBL4062945)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C38H44NO10P/c1-38(2,3)31-17-12-28(13-18-31)29-14-19-32(20-15-29)49-33-10-6-8-27(24-33)25-46-35-11-5-4-9-30(35)16-21-36(40)45-22-7-23-47-50(43,44)48-26-34(39)37(41)42/h4-6,8-15,17-20,24,34H,7,16,21-23,25-26,39H2,1-3H3,(H,41,42)(H,43,44)/t34-/s2
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n/an/an/an/a 7.90n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238938
PNG
(CHEMBL4095241)
Show SMILES CC(C)(C)c1cccc(c1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C38H44NO10P/c1-38(2,3)31-12-7-11-30(24-31)28-15-18-32(19-16-28)49-33-13-6-9-27(23-33)25-46-35-14-5-4-10-29(35)17-20-36(40)45-21-8-22-47-50(43,44)48-26-34(39)37(41)42/h4-7,9-16,18-19,23-24,34H,8,17,20-22,25-26,39H2,1-3H3,(H,41,42)(H,43,44)/t34-/s2
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n/an/an/an/a 14n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human plasma renin


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238938
PNG
(CHEMBL4095241)
Show SMILES CC(C)(C)c1cccc(c1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C38H44NO10P/c1-38(2,3)31-12-7-11-30(24-31)28-15-18-32(19-16-28)49-33-13-6-9-27(23-33)25-46-35-14-5-4-10-29(35)17-20-36(40)45-21-8-22-47-50(43,44)48-26-34(39)37(41)42/h4-7,9-16,18-19,23-24,34H,8,17,20-22,25-26,39H2,1-3H3,(H,41,42)(H,43,44)/t34-/s2
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n/an/an/an/a 14n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238938
PNG
(CHEMBL4095241)
Show SMILES CC(C)(C)c1cccc(c1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C38H44NO10P/c1-38(2,3)31-12-7-11-30(24-31)28-15-18-32(19-16-28)49-33-13-6-9-27(23-33)25-46-35-14-5-4-10-29(35)17-20-36(40)45-21-8-22-47-50(43,44)48-26-34(39)37(41)42/h4-7,9-16,18-19,23-24,34H,8,17,20-22,25-26,39H2,1-3H3,(H,41,42)(H,43,44)/t34-/s2
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n/an/an/an/a 15n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238938
PNG
(CHEMBL4095241)
Show SMILES CC(C)(C)c1cccc(c1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C38H44NO10P/c1-38(2,3)31-12-7-11-30(24-31)28-15-18-32(19-16-28)49-33-13-6-9-27(23-33)25-46-35-14-5-4-10-29(35)17-20-36(40)45-21-8-22-47-50(43,44)48-26-34(39)37(41)42/h4-7,9-16,18-19,23-24,34H,8,17,20-22,25-26,39H2,1-3H3,(H,41,42)(H,43,44)/t34-/s2
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n/an/an/an/a 15n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238936
PNG
(CHEMBL4098603)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C40H40NO10P/c41-37(40(43)44)28-50-52(45,46)49-25-7-24-47-39(42)23-20-34-11-4-5-13-38(34)48-27-29-8-6-12-36(26-29)51-35-21-18-33(19-22-35)32-16-14-31(15-17-32)30-9-2-1-3-10-30/h1-6,8-19,21-22,26,37H,7,20,23-25,27-28,41H2,(H,43,44)(H,45,46)/t37-/s2
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n/an/an/an/a 18n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238936
PNG
(CHEMBL4098603)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C40H40NO10P/c41-37(40(43)44)28-50-52(45,46)49-25-7-24-47-39(42)23-20-34-11-4-5-13-38(34)48-27-29-8-6-12-36(26-29)51-35-21-18-33(19-22-35)32-16-14-31(15-17-32)30-9-2-1-3-10-30/h1-6,8-19,21-22,26,37H,7,20,23-25,27-28,41H2,(H,43,44)(H,45,46)/t37-/s2
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n/an/an/an/a 18n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238940
PNG
(CHEMBL4096239)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C29H34NO10P/c1-21-10-13-24(14-11-21)40-25-8-4-6-22(18-25)19-37-27-9-3-2-7-23(27)12-15-28(31)36-16-5-17-38-41(34,35)39-20-26(30)29(32)33/h2-4,6-11,13-14,18,26H,5,12,15-17,19-20,30H2,1H3,(H,32,33)(H,34,35)/t26-/s2
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n/an/an/an/a 27n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238940
PNG
(CHEMBL4096239)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C29H34NO10P/c1-21-10-13-24(14-11-21)40-25-8-4-6-22(18-25)19-37-27-9-3-2-7-23(27)12-15-28(31)36-16-5-17-38-41(34,35)39-20-26(30)29(32)33/h2-4,6-11,13-14,18,26H,5,12,15-17,19-20,30H2,1H3,(H,32,33)(H,34,35)/t26-/s2
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n/an/an/an/a 27n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177130
PNG
(CHEMBL3815069)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)OC[C@H]3OCCC[C@H]3OP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C32H38NO11P/c1-22-11-14-25(15-12-22)43-26-8-4-6-23(18-26)19-40-28-9-3-2-7-24(28)13-16-31(34)41-21-30-29(10-5-17-39-30)44-45(37,38)42-20-27(33)32(35)36/h2-4,6-9,11-12,14-15,18,27,29-30H,5,10,13,16-17,19-21,33H2,1H3,(H,35,36)(H,37,38)/t27-,29+,30+/s2
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n/an/an/an/a 35n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177140
PNG
(CHEMBL3814525)
Show SMILES N[C@@H](COP(O)(=O)O[C@@H]1CCCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(O)=O
Show InChI InChI=1/C31H35ClNO11P/c32-23-11-13-24(14-12-23)43-25-7-3-5-21(17-25)18-40-27-8-2-1-6-22(27)10-15-30(34)41-20-29-28(9-4-16-39-29)44-45(37,38)42-19-26(33)31(35)36/h1-3,5-8,11-14,17,26,28-29H,4,9-10,15-16,18-20,33H2,(H,35,36)(H,37,38)/t26-,28+,29+/s2
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n/an/an/an/a 36n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177130
PNG
(CHEMBL3815069)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)OC[C@H]3OCCC[C@H]3OP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C32H38NO11P/c1-22-11-14-25(15-12-22)43-26-8-4-6-23(18-26)19-40-28-9-3-2-7-24(28)13-16-31(34)41-21-30-29(10-5-17-39-30)44-45(37,38)42-20-27(33)32(35)36/h2-4,6-9,11-12,14-15,18,27,29-30H,5,10,13,16-17,19-21,33H2,1H3,(H,35,36)(H,37,38)/t27-,29+,30+/s2
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n/an/an/an/a 36n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177140
PNG
(CHEMBL3814525)
Show SMILES N[C@@H](COP(O)(=O)O[C@@H]1CCCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(O)=O
Show InChI InChI=1/C31H35ClNO11P/c32-23-11-13-24(14-12-23)43-25-7-3-5-21(17-25)18-40-27-8-2-1-6-22(27)10-15-30(34)41-20-29-28(9-4-16-39-29)44-45(37,38)42-19-26(33)31(35)36/h1-3,5-8,11-14,17,26,28-29H,4,9-10,15-16,18-20,33H2,(H,35,36)(H,37,38)/t26-,28+,29+/s2
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n/an/an/an/a 37n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238940
PNG
(CHEMBL4096239)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C29H34NO10P/c1-21-10-13-24(14-11-21)40-25-8-4-6-22(18-25)19-37-27-9-3-2-7-23(27)12-15-28(31)36-16-5-17-38-41(34,35)39-20-26(30)29(32)33/h2-4,6-11,13-14,18,26H,5,12,15-17,19-20,30H2,1H3,(H,32,33)(H,34,35)/t26-/s2
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n/an/an/an/a 39n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238940
PNG
(CHEMBL4096239)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C29H34NO10P/c1-21-10-13-24(14-11-21)40-25-8-4-6-22(18-25)19-37-27-9-3-2-7-23(27)12-15-28(31)36-16-5-17-38-41(34,35)39-20-26(30)29(32)33/h2-4,6-11,13-14,18,26H,5,12,15-17,19-20,30H2,1H3,(H,32,33)(H,34,35)/t26-/s2
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n/an/an/an/a 39n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238936
PNG
(CHEMBL4098603)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C40H40NO10P/c41-37(40(43)44)28-50-52(45,46)49-25-7-24-47-39(42)23-20-34-11-4-5-13-38(34)48-27-29-8-6-12-36(26-29)51-35-21-18-33(19-22-35)32-16-14-31(15-17-32)30-9-2-1-3-10-30/h1-6,8-19,21-22,26,37H,7,20,23-25,27-28,41H2,(H,43,44)(H,45,46)/t37-/s2
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n/an/an/an/a 41n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238936
PNG
(CHEMBL4098603)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C40H40NO10P/c41-37(40(43)44)28-50-52(45,46)49-25-7-24-47-39(42)23-20-34-11-4-5-13-38(34)48-27-29-8-6-12-36(26-29)51-35-21-18-33(19-22-35)32-16-14-31(15-17-32)30-9-2-1-3-10-30/h1-6,8-19,21-22,26,37H,7,20,23-25,27-28,41H2,(H,43,44)(H,45,46)/t37-/s2
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n/an/an/an/a 41n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238934
PNG
(CHEMBL4090880)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C34H36NO10P/c35-31(34(37)38)24-44-46(39,40)43-21-7-20-41-33(36)19-16-28-11-4-5-13-32(28)42-23-25-8-6-12-30(22-25)45-29-17-14-27(15-18-29)26-9-2-1-3-10-26/h1-6,8-15,17-18,22,31H,7,16,19-21,23-24,35H2,(H,37,38)(H,39,40)/t31-/s2
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n/an/an/an/a 45n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238934
PNG
(CHEMBL4090880)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C34H36NO10P/c35-31(34(37)38)24-44-46(39,40)43-21-7-20-41-33(36)19-16-28-11-4-5-13-32(28)42-23-25-8-6-12-30(22-25)45-29-17-14-27(15-18-29)26-9-2-1-3-10-26/h1-6,8-15,17-18,22,31H,7,16,19-21,23-24,35H2,(H,37,38)(H,39,40)/t31-/s2
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n/an/an/an/a 46n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238937
PNG
(CHEMBL4071570)
Show SMILES CCCCCCOc1ccc(cc1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C40H48NO11P/c1-2-3-4-7-24-47-34-19-14-31(15-20-34)32-16-21-35(22-17-32)52-36-12-8-10-30(27-36)28-49-38-13-6-5-11-33(38)18-23-39(42)48-25-9-26-50-53(45,46)51-29-37(41)40(43)44/h5-6,8,10-17,19-22,27,37H,2-4,7,9,18,23-26,28-29,41H2,1H3,(H,43,44)(H,45,46)/t37-/s2
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n/an/an/an/a 49n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238937
PNG
(CHEMBL4071570)
Show SMILES CCCCCCOc1ccc(cc1)-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C40H48NO11P/c1-2-3-4-7-24-47-34-19-14-31(15-20-34)32-16-21-35(22-17-32)52-36-12-8-10-30(27-36)28-49-38-13-6-5-11-33(38)18-23-39(42)48-25-9-26-50-53(45,46)51-29-37(41)40(43)44/h5-6,8,10-17,19-22,27,37H,2-4,7,9,18,23-26,28-29,41H2,1H3,(H,43,44)(H,45,46)/t37-/s2
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n/an/an/an/a 49n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177132
PNG
(CHEMBL3814818)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)O[C@@H]3CCCO[C@@H]3COP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C32H38NO11P/c1-22-11-14-25(15-12-22)43-26-8-4-6-23(18-26)19-40-28-9-3-2-7-24(28)13-16-31(34)44-29-10-5-17-39-30(29)21-42-45(37,38)41-20-27(33)32(35)36/h2-4,6-9,11-12,14-15,18,27,29-30H,5,10,13,16-17,19-21,33H2,1H3,(H,35,36)(H,37,38)/t27-,29+,30+/s2
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n/an/an/an/a 76n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177132
PNG
(CHEMBL3814818)
Show SMILES Cc1ccc(Oc2cccc(COc3ccccc3CCC(=O)O[C@@H]3CCCO[C@@H]3COP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C32H38NO11P/c1-22-11-14-25(15-12-22)43-26-8-4-6-23(18-26)19-40-28-9-3-2-7-24(28)13-16-31(34)44-29-10-5-17-39-30(29)21-42-45(37,38)41-20-27(33)32(35)36/h2-4,6-9,11-12,14-15,18,27,29-30H,5,10,13,16-17,19-21,33H2,1H3,(H,35,36)(H,37,38)/t27-,29+,30+/s2
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n/an/an/an/a 77n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238939
PNG
(CHEMBL4067822)
Show SMILES Cc1ccccc1-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C35H38NO10P/c1-25-8-2-4-12-31(25)27-14-17-29(18-15-27)46-30-11-6-9-26(22-30)23-43-33-13-5-3-10-28(33)16-19-34(37)42-20-7-21-44-47(40,41)45-24-32(36)35(38)39/h2-6,8-15,17-18,22,32H,7,16,19-21,23-24,36H2,1H3,(H,38,39)(H,40,41)/t32-/s2
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n/an/an/an/a 78n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238934
PNG
(CHEMBL4090880)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C34H36NO10P/c35-31(34(37)38)24-44-46(39,40)43-21-7-20-41-33(36)19-16-28-11-4-5-13-32(28)42-23-25-8-6-12-30(22-25)45-29-17-14-27(15-18-29)26-9-2-1-3-10-26/h1-6,8-15,17-18,22,31H,7,16,19-21,23-24,35H2,(H,37,38)(H,39,40)/t31-/s2
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n/an/an/an/a 78n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238934
PNG
(CHEMBL4090880)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(cc2)-c2ccccc2)c1)C(O)=O
Show InChI InChI=1/C34H36NO10P/c35-31(34(37)38)24-44-46(39,40)43-21-7-20-41-33(36)19-16-28-11-4-5-13-32(28)42-23-25-8-6-12-30(22-25)45-29-17-14-27(15-18-29)26-9-2-1-3-10-26/h1-6,8-15,17-18,22,31H,7,16,19-21,23-24,35H2,(H,37,38)(H,39,40)/t31-/s2
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n/an/an/an/a 78n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238939
PNG
(CHEMBL4067822)
Show SMILES Cc1ccccc1-c1ccc(Oc2cccc(COc3ccccc3CCC(=O)OCCCOP(O)(=O)OC[C@H](N)C(O)=O)c2)cc1
Show InChI InChI=1/C35H38NO10P/c1-25-8-2-4-12-31(25)27-14-17-29(18-15-27)46-30-11-6-9-26(22-30)23-43-33-13-5-3-10-28(33)16-19-34(37)42-20-7-21-44-47(40,41)45-24-32(36)35(38)39/h2-6,8-15,17-18,22,32H,7,16,19-21,23-24,36H2,1H3,(H,38,39)(H,40,41)/t32-/s2
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n/an/an/an/a 78n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238955
PNG
(CHEMBL4090455)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Br)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31BrNO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 81n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238955
PNG
(CHEMBL4090455)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Br)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31BrNO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 82n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238947
PNG
(CHEMBL4072692)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(O)=O
Show InChI InChI=1/C28H32NO10P/c29-25(28(31)32)20-38-40(33,34)37-17-7-16-35-27(30)15-14-22-9-4-5-13-26(22)36-19-21-8-6-12-24(18-21)39-23-10-2-1-3-11-23/h1-6,8-13,18,25H,7,14-17,19-20,29H2,(H,31,32)(H,33,34)/t25-/s2
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n/an/an/an/a 90n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50238947
PNG
(CHEMBL4072692)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(O)=O
Show InChI InChI=1/C28H32NO10P/c29-25(28(31)32)20-38-40(33,34)37-17-7-16-35-27(30)15-14-22-9-4-5-13-26(22)36-19-21-8-6-12-24(18-21)39-23-10-2-1-3-11-23/h1-6,8-13,18,25H,7,14-17,19-20,29H2,(H,31,32)(H,33,34)/t25-/s2
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n/an/an/an/a 95n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human plasma renin


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238954
PNG
(CHEMBL4100630)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(I)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31INO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 100n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177122
PNG
(CHEMBL3814362)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)OCC1OCCCC1OP(O)(=O)OCC(N)C(O)=O
Show InChI InChI=1/C27H50NO9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-26(29)35-22-25-24(18-17-20-34-25)37-38(32,33)36-21-23(28)27(30)31/h9-10,23-25H,2-8,11-22,28H2,1H3,(H,30,31)(H,32,33)/b10-9-
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n/an/an/an/a 100n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238954
PNG
(CHEMBL4100630)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(I)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31INO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 102n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238957
PNG
(CHEMBL4098171)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(O)=O
Show InChI InChI=1/C28H30Cl2NO10P/c29-23-11-10-22(16-24(23)30)41-21-7-3-5-19(15-21)17-38-26-8-2-1-6-20(26)9-12-27(32)37-13-4-14-39-42(35,36)40-18-25(31)28(33)34/h1-3,5-8,10-11,15-16,25H,4,9,12-14,17-18,31H2,(H,33,34)(H,35,36)/t25-/s2
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n/an/an/an/a 105n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238957
PNG
(CHEMBL4098171)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(O)=O
Show InChI InChI=1/C28H30Cl2NO10P/c29-23-11-10-22(16-24(23)30)41-21-7-3-5-19(15-21)17-38-26-8-2-1-6-20(26)9-12-27(32)37-13-4-14-39-42(35,36)40-18-25(31)28(33)34/h1-3,5-8,10-11,15-16,25H,4,9,12-14,17-18,31H2,(H,33,34)(H,35,36)/t25-/s2
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n/an/an/an/a 110n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177118
PNG
(CHEMBL3814763)
Show SMILES CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(O)(=O)OC[C@H](N)C(O)=O
Show InChI InChI=1/C29H48NO10P/c1-2-3-4-5-6-7-8-9-12-19-36-25-15-11-10-14-23(25)17-18-28(31)38-22-27-26(16-13-20-37-27)40-41(34,35)39-21-24(30)29(32)33/h10-11,14-15,24,26-27H,2-9,12-13,16-22,30H2,1H3,(H,32,33)(H,34,35)/t24-,26+,27+/s2
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n/an/an/an/a 110n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177118
PNG
(CHEMBL3814763)
Show SMILES CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(O)(=O)OC[C@H](N)C(O)=O
Show InChI InChI=1/C29H48NO10P/c1-2-3-4-5-6-7-8-9-12-19-36-25-15-11-10-14-23(25)17-18-28(31)38-22-27-26(16-13-20-37-27)40-41(34,35)39-21-24(30)29(32)33/h10-11,14-15,24,26-27H,2-9,12-13,16-22,30H2,1H3,(H,32,33)(H,34,35)/t24-,26+,27+/s2
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n/an/an/an/a 110n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238958
PNG
(CHEMBL4071116)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31ClNO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 115n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238956
PNG
(CHEMBL4062480)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(F)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31FNO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 117n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177131
PNG
(CHEMBL3815141)
Show SMILES N[C@@H](COP(O)(=O)OC[C@H]1OCCC[C@H]1OC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(O)=O
Show InChI InChI=1/C31H35ClNO11P/c32-23-11-13-24(14-12-23)43-25-7-3-5-21(17-25)18-40-27-8-2-1-6-22(27)10-15-30(34)44-28-9-4-16-39-29(28)20-42-45(37,38)41-19-26(33)31(35)36/h1-3,5-8,11-14,17,26,28-29H,4,9-10,15-16,18-20,33H2,(H,35,36)(H,37,38)/t26-,28+,29+/s2
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n/an/an/an/a 117n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177131
PNG
(CHEMBL3815141)
Show SMILES N[C@@H](COP(O)(=O)OC[C@H]1OCCC[C@H]1OC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(O)=O
Show InChI InChI=1/C31H35ClNO11P/c32-23-11-13-24(14-12-23)43-25-7-3-5-21(17-25)18-40-27-8-2-1-6-22(27)10-15-30(34)44-28-9-4-16-39-29(28)20-42-45(37,38)41-19-26(33)31(35)36/h1-3,5-8,11-14,17,26,28-29H,4,9-10,15-16,18-20,33H2,(H,35,36)(H,37,38)/t26-,28+,29+/s2
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n/an/an/an/a 120n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238958
PNG
(CHEMBL4071116)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31ClNO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 120n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50238956
PNG
(CHEMBL4062480)
Show SMILES N[C@@H](COP(O)(=O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(F)cc2)c1)C(O)=O
Show InChI InChI=1/C28H31FNO10P/c29-22-10-12-23(13-11-22)40-24-7-3-5-20(17-24)18-37-26-8-2-1-6-21(26)9-14-27(31)36-15-4-16-38-41(34,35)39-19-25(30)28(32)33/h1-3,5-8,10-13,17,25H,4,9,14-16,18-19,30H2,(H,32,33)(H,34,35)/t25-/s2
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n/an/an/an/a 120n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177117
PNG
(CHEMBL3814092)
Show SMILES N[C@@H](COP(O)(=O)O[C@@H]1CCCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(O)=O
Show InChI InChI=1/C31H36NO11P/c32-26(31(34)35)20-41-44(36,37)43-28-14-7-17-38-29(28)21-40-30(33)16-15-23-9-4-5-13-27(23)39-19-22-8-6-12-25(18-22)42-24-10-2-1-3-11-24/h1-6,8-13,18,26,28-29H,7,14-17,19-21,32H2,(H,34,35)(H,36,37)/t26-,28+,29+/s2
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n/an/an/an/a 138n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
G protein-coupled receptor 34


(Mus musculus)
BDBM50177117
PNG
(CHEMBL3814092)
Show SMILES N[C@@H](COP(O)(=O)O[C@@H]1CCCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(O)=O
Show InChI InChI=1/C31H36NO11P/c32-26(31(34)35)20-41-44(36,37)43-28-14-7-17-38-29(28)21-40-30(33)16-15-23-9-4-5-13-27(23)39-19-22-8-6-12-25(18-22)42-24-10-2-1-3-11-24/h1-6,8-13,18,26,28-29H,7,14-17,19-21,32H2,(H,34,35)(H,36,37)/t26-,28+,29+/s2
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n/an/an/an/a 140n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalp...


J Med Chem 59: 3750-76 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01925
BindingDB Entry DOI: 10.7270/Q2542QHQ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50177117
PNG
(CHEMBL3814092)
Show SMILES N[C@@H](COP(O)(=O)O[C@@H]1CCCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(O)=O
Show InChI InChI=1/C31H36NO11P/c32-26(31(34)35)20-41-44(36,37)43-28-14-7-17-38-29(28)21-40-30(33)16-15-23-9-4-5-13-27(23)39-19-22-8-6-12-25(18-22)42-24-10-2-1-3-11-24/h1-6,8-13,18,26,28-29H,7,14-17,19-21,32H2,(H,34,35)(H,36,37)/t26-,28+,29+/s2
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n/an/an/an/a 150n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50177117
PNG
(CHEMBL3814092)
Show SMILES N[C@@H](COP(O)(=O)O[C@@H]1CCCO[C@@H]1COC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(O)=O
Show InChI InChI=1/C31H36NO11P/c32-26(31(34)35)20-41-44(36,37)43-28-14-7-17-38-29(28)21-40-30(33)16-15-23-9-4-5-13-27(23)39-19-22-8-6-12-25(18-22)42-24-10-2-1-3-11-24/h1-6,8-13,18,26,28-29H,7,14-17,19-21,32H2,(H,34,35)(H,36,37)/t26-,28+,29+/s2
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n/an/an/an/a 151n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha re...


J Med Chem 60: 6384-6399 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00693
BindingDB Entry DOI: 10.7270/Q2FX7CR1
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 34


(Homo sapiens (Human))
BDBM50096361
PNG
(CHEMBL3577175)
Show SMILES CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(O)(=O)OC[C@H](N)C(O)=O)c1
Show InChI InChI=1/C30H52NO10P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-20-38-27-17-15-16-25(21-27)18-19-29(33)39-22-26(32)23-40-42(36,37)41-24-28(31)30(34)35/h15-17,21,26,28,32H,2-14,18-20,22-24,31H2,1H3,(H,34,35)(H,36,37)/t26-,28+/s2
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n/an/an/an/a 158n/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Agonist activity at GPR34 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay


J Med Chem 58: 4204-19 (2015)


Article DOI: 10.1021/jm5020082
BindingDB Entry DOI: 10.7270/Q2Q81FTD
More data for this
Ligand-Target Pair
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