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Found 38 hits Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 52'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252102
PNG
(CHEMBL4059658)
Show SMILES Cc1nc(Cc2cc(F)cc(c2)C(F)(F)F)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C20H16F4N2OS/c1-10-5-13(3-4-16(10)19(25)27)18-11(2)26-17(28-18)8-12-6-14(20(22,23)24)9-15(21)7-12/h3-7,9H,8H2,1-2H3,(H2,25,27)
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n/an/an/an/a 11n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252099
PNG
(CHEMBL4087237)
Show SMILES Cc1cc(ccc1C(N)=O)-c1cc(Cc2cc(F)cc(c2)C(F)(F)F)nn1C
Show InChI InChI=1S/C20H17F4N3O/c1-11-5-13(3-4-17(11)19(25)28)18-10-16(26-27(18)2)8-12-6-14(20(22,23)24)9-15(21)7-12/h3-7,9-10H,8H2,1-2H3,(H2,25,28)
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n/an/an/an/a 23n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252191
PNG
(CHEMBL4075971)
Show SMILES Cc1nc(Cc2cc(F)cc(Cl)c2)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C19H16ClFN2OS/c1-10-5-13(3-4-16(10)19(22)24)18-11(2)23-17(25-18)8-12-6-14(20)9-15(21)7-12/h3-7,9H,8H2,1-2H3,(H2,22,24)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022153
PNG
(CHEMBL3299119)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2oc(Cc3cccc(c3)C(F)(F)F)cc12
Show InChI InChI=1S/C25H20F3NO3/c26-25(27,28)19-7-1-4-16(12-19)13-20-15-22-21(8-3-9-23(22)32-20)17-5-2-6-18(14-17)24(31)29-10-11-30/h1-9,12,14-15,30H,10-11,13H2,(H,29,31)
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n/an/an/an/a 28n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022190
PNG
(CHEMBL3298233)
Show SMILES COCCNC(=O)c1cccc(c1)-c1cccc2cc(Cc3cc(F)cc(Cl)c3)sc12
Show InChI InChI=1S/C25H21ClFNO2S/c1-30-9-8-28-25(29)19-6-2-4-17(13-19)23-7-3-5-18-14-22(31-24(18)23)12-16-10-20(26)15-21(27)11-16/h2-7,10-11,13-15H,8-9,12H2,1H3,(H,28,29)
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n/an/an/an/a 30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022156
PNG
(CHEMBL3299120)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2cc(Cc3cccc(c3)C(F)(F)F)oc12
Show InChI InChI=1S/C25H20F3NO3/c26-25(27,28)20-8-1-4-16(12-20)13-21-15-18-6-3-9-22(23(18)32-21)17-5-2-7-19(14-17)24(31)29-10-11-30/h1-9,12,14-15,30H,10-11,13H2,(H,29,31)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022158
PNG
(CHEMBL3299122)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2cc(Cc3cccc(c3)C(F)(F)F)sc12
Show InChI InChI=1S/C25H20F3NO2S/c26-25(27,28)20-8-1-4-16(12-20)13-21-15-18-6-3-9-22(23(18)32-21)17-5-2-7-19(14-17)24(31)29-10-11-30/h1-9,12,14-15,30H,10-11,13H2,(H,29,31)
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n/an/an/an/a 37n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022157
PNG
(CHEMBL3299121)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2sc(Cc3cccc(c3)C(F)(F)F)cc12
Show InChI InChI=1S/C25H20F3NO2S/c26-25(27,28)19-7-1-4-16(12-19)13-20-15-22-21(8-3-9-23(22)32-20)17-5-2-6-18(14-17)24(31)29-10-11-30/h1-9,12,14-15,30H,10-11,13H2,(H,29,31)
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n/an/an/an/a 38n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022159
PNG
(CHEMBL3299123)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2nn(Cc3cccc(c3)C(F)(F)F)cc12
Show InChI InChI=1S/C24H20F3N3O2/c25-24(26,27)19-7-1-4-16(12-19)14-30-15-21-20(8-3-9-22(21)29-30)17-5-2-6-18(13-17)23(32)28-10-11-31/h1-9,12-13,15,31H,10-11,14H2,(H,28,32)
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n/an/an/an/a 39n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022189
PNG
(CHEMBL3297811)
Show SMILES COCCNC(=O)c1cccc(c1)-c1cccc2cc(Cc3cccc(c3)C(F)(F)F)sc12
Show InChI InChI=1S/C26H22F3NO2S/c1-32-12-11-30-25(31)20-8-3-6-18(15-20)23-10-4-7-19-16-22(33-24(19)23)14-17-5-2-9-21(13-17)26(27,28)29/h2-10,13,15-16H,11-12,14H2,1H3,(H,30,31)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022170
PNG
(CHEMBL3297810)
Show SMILES NC(=O)CNC(=O)c1cccc(c1)-c1cccc2cc(Cc3cccc(c3)C(F)(F)F)sc12
Show InChI InChI=1S/C25H19F3N2O2S/c26-25(27,28)19-8-1-4-15(10-19)11-20-13-17-6-3-9-21(23(17)33-20)16-5-2-7-18(12-16)24(32)30-14-22(29)31/h1-10,12-13H,11,14H2,(H2,29,31)(H,30,32)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252190
PNG
(CHEMBL4101517)
Show SMILES Cc1nc(Cc2cc(F)cc(c2)C(F)(F)F)cn1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C20H17F4N3O/c1-11-5-17(3-4-18(11)19(25)28)27-10-16(26-12(27)2)8-13-6-14(20(22,23)24)9-15(21)7-13/h3-7,9-10H,8H2,1-2H3,(H2,25,28)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022162
PNG
(CHEMBL3299124)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2cn(Cc3cccc(c3)C(F)(F)F)nc12
Show InChI InChI=1S/C24H20F3N3O2/c25-24(26,27)20-8-1-4-16(12-20)14-30-15-19-7-3-9-21(22(19)29-30)17-5-2-6-18(13-17)23(32)28-10-11-31/h1-9,12-13,15,31H,10-11,14H2,(H,28,32)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252214
PNG
(CHEMBL4080724)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C20H17F3N2OS/c1-11-8-14(6-7-16(11)19(24)26)18-12(2)25-17(27-18)10-13-4-3-5-15(9-13)20(21,22)23/h3-9H,10H2,1-2H3,(H2,24,26)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252092
PNG
(CHEMBL4082756)
Show SMILES Cc1nc(Cc2cc(F)cc(c2)C(F)(F)F)nn1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C19H16F4N4O/c1-10-5-15(3-4-16(10)18(24)28)27-11(2)25-17(26-27)8-12-6-13(19(21,22)23)9-14(20)7-12/h3-7,9H,8H2,1-2H3,(H2,24,28)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022169
PNG
(CHEMBL3297809)
Show SMILES Cc1c(Cc2cccc(c2)C(F)(F)F)oc2c(cccc12)-c1cccc(c1)C(=O)NCCO
Show InChI InChI=1S/C26H22F3NO3/c1-16-21-9-4-10-22(18-6-3-7-19(15-18)25(32)30-11-12-31)24(21)33-23(16)14-17-5-2-8-20(13-17)26(27,28)29/h2-10,13,15,31H,11-12,14H2,1H3,(H,30,32)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022254
PNG
(CHEMBL3298234)
Show SMILES NC(=O)CNC(=O)c1cccc(c1)-c1ccc(F)c2cc(Cc3cccc(c3)C(F)(F)F)sc12
Show InChI InChI=1S/C25H18F4N2O2S/c26-21-8-7-19(15-4-2-5-16(11-15)24(33)31-13-22(30)32)23-20(21)12-18(34-23)10-14-3-1-6-17(9-14)25(27,28)29/h1-9,11-12H,10,13H2,(H2,30,32)(H,31,33)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252187
PNG
(CHEMBL4099668)
Show SMILES CCc1cc(ccc1C(N)=O)-c1sc(Cc2cccc(c2)C(F)(F)F)nc1C
Show InChI InChI=1S/C21H19F3N2OS/c1-3-14-11-15(7-8-17(14)20(25)27)19-12(2)26-18(28-19)10-13-5-4-6-16(9-13)21(22,23)24/h4-9,11H,3,10H2,1-2H3,(H2,25,27)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252151
PNG
(CHEMBL4073584)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(C(N)=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H14F6N2OS/c1-10-17(12-5-6-14(18(27)29)15(9-12)20(24,25)26)30-16(28-10)8-11-3-2-4-13(7-11)19(21,22)23/h2-7,9H,8H2,1H3,(H2,27,29)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252138
PNG
(CHEMBL4095110)
Show SMILES Cc1nc(Cc2cccc(Cl)c2)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C19H17ClN2OS/c1-11-8-14(6-7-16(11)19(21)23)18-12(2)22-17(24-18)10-13-4-3-5-15(20)9-13/h3-9H,10H2,1-2H3,(H2,21,23)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252140
PNG
(CHEMBL4081439)
Show SMILES COc1cccc(Cc2nc(C)c(s2)-c2ccc(C(N)=O)c(C)c2)c1
Show InChI InChI=1S/C20H20N2O2S/c1-12-9-15(7-8-17(12)20(21)23)19-13(2)22-18(25-19)11-14-5-4-6-16(10-14)24-3/h4-10H,11H2,1-3H3,(H2,21,23)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252152
PNG
(CHEMBL4062229)
Show SMILES COc1cc(ccc1C(N)=O)-c1sc(Cc2cccc(c2)C(F)(F)F)nc1C
Show InChI InChI=1S/C20H17F3N2O2S/c1-11-18(13-6-7-15(19(24)26)16(10-13)27-2)28-17(25-11)9-12-4-3-5-14(8-12)20(21,22)23/h3-8,10H,9H2,1-2H3,(H2,24,26)
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n/an/an/an/a 170n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022165
PNG
(CHEMBL3297807)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2CC(Cc3cccc(c3)C(F)(F)F)Oc12
Show InChI InChI=1/C25H22F3NO3/c26-25(27,28)20-8-1-4-16(12-20)13-21-15-18-6-3-9-22(23(18)32-21)17-5-2-7-19(14-17)24(31)29-10-11-30/h1-9,12,14,21,30H,10-11,13,15H2,(H,29,31)
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n/an/an/an/a 209n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252136
PNG
(CHEMBL4064577)
Show SMILES Cc1nc(Cc2ccc(Cl)cc2)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C19H17ClN2OS/c1-11-9-14(5-8-16(11)19(21)23)18-12(2)22-17(24-18)10-13-3-6-15(20)7-4-13/h3-9H,10H2,1-2H3,(H2,21,23)
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n/an/an/an/a 210n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252189
PNG
(CHEMBL4091030)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C19H15F3N2OS/c1-11-17(13-5-7-14(8-6-13)18(23)25)26-16(24-11)10-12-3-2-4-15(9-12)19(20,21)22/h2-9H,10H2,1H3,(H2,23,25)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252192
PNG
(CHEMBL4070849)
Show SMILES Cc1nc(Cc2cccc(F)c2)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C19H17FN2OS/c1-11-8-14(6-7-16(11)19(21)23)18-12(2)22-17(24-18)10-13-4-3-5-15(20)9-13/h3-9H,10H2,1-2H3,(H2,21,23)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022151
PNG
(CHEMBL3299118)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc(OCCc2cc(F)cc(Cl)c2)n1
Show InChI InChI=1S/C22H20ClFN2O3/c23-18-11-15(12-19(24)14-18)7-10-29-21-6-2-5-20(26-21)16-3-1-4-17(13-16)22(28)25-8-9-27/h1-6,11-14,27H,7-10H2,(H,25,28)
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n/an/an/an/a 347n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at GPR52 (unknown origin)


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252186
PNG
(CHEMBL4072782)
Show SMILES CC(C)c1cc(ccc1C(N)=O)-c1sc(Cc2cccc(c2)C(F)(F)F)nc1C
Show InChI InChI=1S/C22H21F3N2OS/c1-12(2)18-11-15(7-8-17(18)21(26)28)20-13(3)27-19(29-20)10-14-5-4-6-16(9-14)22(23,24)25/h4-9,11-12H,10H2,1-3H3,(H2,26,28)
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n/an/an/an/a 370n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252213
PNG
(CHEMBL4083957)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(C(N)=O)c(F)c1
Show InChI InChI=1S/C19H14F4N2OS/c1-10-17(12-5-6-14(18(24)26)15(20)9-12)27-16(25-10)8-11-3-2-4-13(7-11)19(21,22)23/h2-7,9H,8H2,1H3,(H2,24,26)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252141
PNG
(CHEMBL4099457)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(cn1)C(N)=O
Show InChI InChI=1S/C18H14F3N3OS/c1-10-16(14-6-5-12(9-23-14)17(22)25)26-15(24-10)8-11-3-2-4-13(7-11)18(19,20)21/h2-7,9H,8H2,1H3,(H2,22,25)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022164
PNG
(CHEMBL3299125)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc2OC(Cc3cccc(c3)C(F)(F)F)Cc12
Show InChI InChI=1/C25H22F3NO3/c26-25(27,28)19-7-1-4-16(12-19)13-20-15-22-21(8-3-9-23(22)32-20)17-5-2-6-18(14-17)24(31)29-10-11-30/h1-9,12,14,20,30H,10-11,13,15H2,(H,29,31)
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n/an/an/an/a 646n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022147
PNG
(CHEMBL3299117)
Show SMILES OCCNC(=O)c1cccc(c1)-c1cccc(OCCc2cccc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C23H21F3N2O3/c24-23(25,26)19-7-1-4-16(14-19)10-13-31-21-9-3-8-20(28-21)17-5-2-6-18(15-17)22(30)27-11-12-29/h1-9,14-15,29H,10-13H2,(H,27,30)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at GPR52 (unknown origin)


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252139
PNG
(CHEMBL4091718)
Show SMILES CN(C)c1cccc(Cc2nc(C)c(s2)-c2ccc(C(N)=O)c(C)c2)c1
Show InChI InChI=1S/C21H23N3OS/c1-13-10-16(8-9-18(13)21(22)25)20-14(2)23-19(26-20)12-15-6-5-7-17(11-15)24(3)4/h5-11H,12H2,1-4H3,(H2,22,25)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252212
PNG
(CHEMBL4100408)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C18H14F3N3OS/c1-10-16(12-5-6-14(17(22)25)23-9-12)26-15(24-10)8-11-3-2-4-13(7-11)18(19,20)21/h2-7,9H,8H2,1H3,(H2,22,25)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252188
PNG
(CHEMBL4098770)
Show SMILES Cc1nc(Cc2cccc(c2)C(F)(F)F)sc1-c1ccc(cc1C)C(N)=O
Show InChI InChI=1S/C20H17F3N2OS/c1-11-8-14(19(24)26)6-7-16(11)18-12(2)25-17(27-18)10-13-4-3-5-15(9-13)20(21,22)23/h3-9H,10H2,1-2H3,(H2,24,26)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50252137
PNG
(CHEMBL4074656)
Show SMILES Cc1nc(Cc2ccccc2Cl)sc1-c1ccc(C(N)=O)c(C)c1
Show InChI InChI=1S/C19H17ClN2OS/c1-11-9-14(7-8-15(11)19(21)23)18-12(2)22-17(24-18)10-13-5-3-4-6-16(13)20/h3-9H,10H2,1-2H3,(H2,21,23)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay


Bioorg Med Chem 25: 3098-3115 (2017)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022152
PNG
(CHEMBL3299018)
Show SMILES COc1ccc(cc1)-c1ccnc(NCCc2ccc(OC)c(OC)c2C)n1
Show InChI InChI=1S/C22H25N3O3/c1-15-16(7-10-20(27-3)21(15)28-4)11-13-23-22-24-14-12-19(25-22)17-5-8-18(26-2)9-6-17/h5-10,12,14H,11,13H2,1-4H3,(H,23,24,25)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 52


(Homo sapiens (Human))
BDBM50022166
PNG
(CHEMBL3297808)
Show SMILES Cc1c(Cc2cccc(c2)C(F)(F)F)oc2cccc(-c3cccc(c3)C(=O)NCCO)c12
Show InChI InChI=1S/C26H22F3NO3/c1-16-23(14-17-5-2-8-20(13-17)26(27,28)29)33-22-10-4-9-21(24(16)22)18-6-3-7-19(15-18)25(32)30-11-12-31/h2-10,13,15,31H,11-12,14H2,1H3,(H,30,32)
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Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay


J Med Chem 57: 5226-37 (2014)


Article DOI: 10.1021/jm5002919
BindingDB Entry DOI: 10.7270/Q2CR5VZD
More data for this
Ligand-Target Pair