BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 177 hits Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 88'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065752
PNG
(CHEMBL3400199)
Show SMILES NC1(CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)c2ccc(cc2)-c2ccccc2)CCCC1
Show InChI InChI=1S/C28H30N2O/c29-28(17-7-8-18-28)20-30(27(31)26-19-25(26)23-11-5-2-6-12-23)24-15-13-22(14-16-24)21-9-3-1-4-10-21/h1-6,9-16,25-26H,7-8,17-20,29H2/t25-,26+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.570n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065770
PNG
(CHEMBL3404056)
Show SMILES N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1)C1CCCCC1
Show InChI InChI=1S/C30H34N2O/c31-29(25-14-8-3-9-15-25)21-32(30(33)28-20-27(28)24-12-6-2-7-13-24)26-18-16-23(17-19-26)22-10-4-1-5-11-22/h1-2,4-7,10-13,16-19,25,27-29H,3,8-9,14-15,20-21,31H2/t27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.660n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065753
PNG
(CHEMBL3400198)
Show SMILES CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H30N2O2/c1-19(31-2)26(28)18-29(27(30)25-17-24(25)22-11-7-4-8-12-22)23-15-13-21(14-16-23)20-9-5-3-6-10-20/h3-16,19,24-26H,17-18,28H2,1-2H3/t19-,24+,25-,26-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.680n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065754
PNG
(CHEMBL3400197)
Show SMILES CC(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H30N2O/c1-19(2)26(28)18-29(27(30)25-17-24(25)22-11-7-4-8-12-22)23-15-13-21(14-16-23)20-9-5-3-6-10-20/h3-16,19,24-26H,17-18,28H2,1-2H3/t24-,25+,26+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065912
PNG
(CHEMBL3404049)
Show SMILES CC(C)C[C@H](N)CN(C(=O)C(C)Cc1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H34N2O/c1-21(2)18-26(29)20-30(28(31)22(3)19-23-10-6-4-7-11-23)27-16-14-25(15-17-27)24-12-8-5-9-13-24/h4-17,21-22,26H,18-20,29H2,1-3H3/t22?,26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.20n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065907
PNG
(CHEMBL3404054)
Show SMILES CC[C@@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H32N2O/c1-3-20(2)27(29)19-30(28(31)26-18-25(26)23-12-8-5-9-13-23)24-16-14-22(15-17-24)21-10-6-4-7-11-21/h4-17,20,25-27H,3,18-19,29H2,1-2H3/t20-,25+,26-,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.40n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065751
PNG
(CHEMBL3400200)
Show SMILES CC(C)(N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H28N2O/c1-26(2,27)18-28(25(29)24-17-23(24)21-11-7-4-8-12-21)22-15-13-20(14-16-22)19-9-5-3-6-10-19/h3-16,23-24H,17-18,27H2,1-2H3/t23-,24+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.40n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065860
PNG
(CHEMBL3404055)
Show SMILES N[C@@H](CC1CCCCC1)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H36N2O/c32-27(20-23-10-4-1-5-11-23)22-33(31(34)30-21-29(30)26-14-8-3-9-15-26)28-18-16-25(17-19-28)24-12-6-2-7-13-24/h2-3,6-9,12-19,23,27,29-30H,1,4-5,10-11,20-22,32H2/t27-,29-,30+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065910
PNG
(CHEMBL3404051)
Show SMILES CC(C)C[C@@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H32N2O/c1-20(2)17-24(29)19-30(28(31)27-18-26(27)23-11-7-4-8-12-23)25-15-13-22(14-16-25)21-9-5-3-6-10-21/h3-16,20,24,26-27H,17-19,29H2,1-2H3/t24-,26+,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.80n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065909
PNG
(CHEMBL3404052)
Show SMILES CN[C@@H](CC(C)C)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H34N2O/c1-21(2)18-25(30-3)20-31(29(32)28-19-27(28)24-12-8-5-9-13-24)26-16-14-23(15-17-26)22-10-6-4-7-11-22/h4-17,21,25,27-28,30H,18-20H2,1-3H3/t25-,27-,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065747
PNG
(CHEMBL3400204)
Show SMILES CCC(CC)C(N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C30H36N2O/c1-3-22(4-2)29(31)19-20-32(30(33)28-21-27(28)25-13-9-6-10-14-25)26-17-15-24(16-18-26)23-11-7-5-8-12-23/h5-18,22,27-29H,3-4,19-21,31H2,1-2H3/t27-,28+,29?/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065743
PNG
(CHEMBL3400208)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C30H34N2O/c33-30(29-21-28(29)26-13-5-2-6-14-26)32(20-19-31-22-23-9-7-8-10-23)27-17-15-25(16-18-27)24-11-3-1-4-12-24/h1-6,11-18,23,28-29,31H,7-10,19-22H2/t28-,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065748
PNG
(CHEMBL3400203)
Show SMILES CC(C)C[C@H](N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H34N2O/c1-21(2)19-25(30)17-18-31(29(32)28-20-27(28)24-11-7-4-8-12-24)26-15-13-23(14-16-26)22-9-5-3-6-10-22/h3-16,21,25,27-28H,17-20,30H2,1-2H3/t25-,27+,28-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065915
PNG
(CHEMBL3401461)
Show SMILES CCCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]1C[C@H]1c1ccccn1
Show InChI InChI=1S/C30H37N3O/c1-4-8-22-10-12-23(13-11-22)24-14-16-25(17-15-24)33(20-28(31)21(3)5-2)30(34)27-19-26(27)29-9-6-7-18-32-29/h6-7,9-18,21,26-28H,4-5,8,19-20,31H2,1-3H3/t21-,26+,27+,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.10n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065916
PNG
(CHEMBL3401460)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(cc1)-c1ccc(OC(C)C)cc1
Show InChI InChI=1S/C30H37N3O2/c1-5-21(4)28(31)19-33(30(34)27-18-26(27)29-8-6-7-17-32-29)24-13-9-22(10-14-24)23-11-15-25(16-12-23)35-20(2)3/h6-17,20-21,26-28H,5,18-19,31H2,1-4H3/t21-,26+,27+,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3.5n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065745
PNG
(CHEMBL3400206)
Show SMILES CCC(C)CNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H34N2O/c1-3-22(2)21-30-18-19-31(29(32)28-20-27(28)25-12-8-5-9-13-25)26-16-14-24(15-17-26)23-10-6-4-7-11-23/h4-17,22,27-28,30H,3,18-21H2,1-2H3/t22?,27-,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.70n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065762
PNG
(CHEMBL3400196)
Show SMILES N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H28N2O/c31-29(25-14-8-3-9-15-25)21-32(30(33)28-20-27(28)24-12-6-2-7-13-24)26-18-16-23(17-19-26)22-10-4-1-5-11-22/h1-19,27-29H,20-21,31H2/t27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.70n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065746
PNG
(CHEMBL3400205)
Show SMILES CC(C)CCNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H34N2O/c1-22(2)17-18-30-19-20-31(29(32)28-21-27(28)25-11-7-4-8-12-25)26-15-13-24(14-16-26)23-9-5-3-6-10-23/h3-16,22,27-28,30H,17-21H2,1-2H3/t27-,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5.10n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065908
PNG
(CHEMBL3404053)
Show SMILES CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1)NC(C)=O
Show InChI InChI=1S/C30H34N2O2/c1-4-21(2)29(31-22(3)33)20-32(30(34)28-19-27(28)25-13-9-6-10-14-25)26-17-15-24(16-18-26)23-11-7-5-8-12-23/h5-18,21,27-29H,4,19-20H2,1-3H3,(H,31,33)/t21-,27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5.80n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065744
PNG
(CHEMBL3400207)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H36N2O/c34-31(30-22-29(30)27-14-8-3-9-15-27)33(21-20-32-23-24-10-4-1-5-11-24)28-18-16-26(17-19-28)25-12-6-2-7-13-25/h2-3,6-9,12-19,24,29-30,32H,1,4-5,10-11,20-23H2/t29-,30+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.60n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065749
PNG
(CHEMBL3400202)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N(CC1CCCNC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H30N2O/c31-28(27-18-26(27)24-11-5-2-6-12-24)30(20-21-8-7-17-29-19-21)25-15-13-23(14-16-25)22-9-3-1-4-10-22/h1-6,9-16,21,26-27,29H,7-8,17-20H2/t21?,26-,27+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065750
PNG
(CHEMBL3400201)
Show SMILES CC(C)(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H32N2O/c1-28(2,3)26(29)19-30(27(31)25-18-24(25)22-12-8-5-9-13-22)23-16-14-21(15-17-23)20-10-6-4-7-11-20/h4-17,24-26H,18-19,29H2,1-3H3/t24-,25+,26+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065917
PNG
(CHEMBL3401459)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(cc1)-c1ccc(COC)cc1
Show InChI InChI=1S/C29H35N3O2/c1-4-20(2)27(30)18-32(29(33)26-17-25(26)28-7-5-6-16-31-28)24-14-12-23(13-15-24)22-10-8-21(9-11-22)19-34-3/h5-16,20,25-27H,4,17-19,30H2,1-3H3/t20-,25+,26+,27+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064752
PNG
(CHEMBL3403781)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CN(C)C)NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C25H36N2O2/c1-6-10-19(2)18-29-23-15-13-22(14-16-23)24(17-27(4)5)26-25(28)20(3)21-11-8-7-9-12-21/h7-9,11-16,19-20,24H,6,10,17-18H2,1-5H3,(H,26,28)/t19?,20-,24-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 29n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065969
PNG
(CHEMBL3400271)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(COC)cc1
Show InChI InChI=1S/C30H36N2O2/c1-4-21(2)29(31)19-32(30(33)28-18-27(28)25-8-6-5-7-9-25)26-16-14-24(15-17-26)23-12-10-22(11-13-23)20-34-3/h5-17,21,27-29H,4,18-20,31H2,1-3H3/t21-,27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 35n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065979
PNG
(CHEMBL3400262)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(CC)cc1
Show InChI InChI=1S/C30H36N2O/c1-4-21(3)29(31)20-32(30(33)28-19-27(28)25-9-7-6-8-10-25)26-17-15-24(16-18-26)23-13-11-22(5-2)12-14-23/h6-18,21,27-29H,4-5,19-20,31H2,1-3H3/t21-,27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 44n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065915
PNG
(CHEMBL3401461)
Show SMILES CCCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]1C[C@H]1c1ccccn1
Show InChI InChI=1S/C30H37N3O/c1-4-8-22-10-12-23(13-11-22)24-14-16-25(17-15-24)33(20-28(31)21(3)5-2)30(34)27-19-26(27)29-9-6-7-18-32-29/h6-7,9-18,21,26-28H,4-5,8,19-20,31H2,1-3H3/t21-,26+,27+,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 3...


Bioorg Med Chem 25: 805-812 (2017)


Article DOI: 10.1016/j.bmc.2016.11.058
BindingDB Entry DOI: 10.7270/Q26T0PNJ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065978
PNG
(CHEMBL3400263)
Show SMILES CCCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C31H38N2O/c1-4-9-23-12-14-24(15-13-23)25-16-18-27(19-17-25)33(21-30(32)22(3)5-2)31(34)29-20-28(29)26-10-7-6-8-11-26/h6-8,10-19,22,28-30H,4-5,9,20-21,32H2,1-3H3/t22-,28-,29+,30+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 61n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065939
PNG
(CHEMBL3400274)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(CC(=O)OC)cc1
Show InChI InChI=1S/C31H36N2O3/c1-4-21(2)29(32)20-33(31(35)28-19-27(28)25-8-6-5-7-9-25)26-16-14-24(15-17-26)23-12-10-22(11-13-23)18-30(34)36-3/h5-17,21,27-29H,4,18-20,32H2,1-3H3/t21-,27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 66n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065975
PNG
(CHEMBL3400266)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(OC(C)C)cc1
Show InChI InChI=1S/C31H38N2O2/c1-5-22(4)30(32)20-33(31(34)29-19-28(29)25-9-7-6-8-10-25)26-15-11-23(12-16-26)24-13-17-27(18-14-24)35-21(2)3/h6-18,21-22,28-30H,5,19-20,32H2,1-4H3/t22-,28-,29+,30+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 72n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064753
PNG
(CHEMBL3403782)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CN1CCN(C)CC1)NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C28H41N3O2/c1-5-9-22(2)21-33-26-14-12-25(13-15-26)27(20-31-18-16-30(4)17-19-31)29-28(32)23(3)24-10-7-6-8-11-24/h6-8,10-15,22-23,27H,5,9,16-21H2,1-4H3,(H,29,32)/t22?,23-,27-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 90n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065974
PNG
(CHEMBL3400267)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C30H36N2O2/c1-4-21(3)29(31)20-32(30(33)28-19-27(28)24-9-7-6-8-10-24)25-15-11-22(12-16-25)23-13-17-26(18-14-23)34-5-2/h6-18,21,27-29H,4-5,19-20,31H2,1-3H3/t21-,27-,28+,29+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 90n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064754
PNG
(CHEMBL3403783)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CN1CCOCC1)NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C27H38N2O3/c1-4-8-21(2)20-32-25-13-11-24(12-14-25)26(19-29-15-17-31-18-16-29)28-27(30)22(3)23-9-6-5-7-10-23/h5-7,9-14,21-22,26H,4,8,15-20H2,1-3H3,(H,28,30)/t21?,22-,26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 91n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064642
PNG
(CHEMBL3403765)
Show SMILES Cc1ccc(cc1)-c1ccc(cc1)[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1
Show InChI InChI=1S/C23H23NO2S/c1-15-4-6-16(7-5-15)17-8-10-18(11-9-17)21(14-25)24-23(26)20-13-19(20)22-3-2-12-27-22/h2-12,19-21,25H,13-14H2,1H3,(H,24,26)/t19-,20-,21-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 93n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065972
PNG
(CHEMBL3400269)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C34H36N2O2/c1-3-24(2)33(35)23-36(34(37)32-22-31(32)27-10-6-4-7-11-27)28-18-14-25(15-19-28)26-16-20-30(21-17-26)38-29-12-8-5-9-13-29/h4-21,24,31-33H,3,22-23,35H2,1-2H3/t24-,31-,32+,33+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 94n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065911
PNG
(CHEMBL3404050)
Show SMILES CC(C)CCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H31NO/c1-21(2)10-9-19-29(28(30)27-20-26(27)24-13-7-4-8-14-24)25-17-15-23(16-18-25)22-11-5-3-6-12-22/h3-8,11-18,21,26-27H,9-10,19-20H2,1-2H3/t26-,27+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064751
PNG
(CHEMBL3403780)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CN)NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C23H32N2O2/c1-4-8-17(2)16-27-21-13-11-20(12-14-21)22(15-24)25-23(26)18(3)19-9-6-5-7-10-19/h5-7,9-14,17-18,22H,4,8,15-16,24H2,1-3H3,(H,25,26)/t17?,18-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065938
PNG
(CHEMBL3400275)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(CCC(=O)OC)cc1
Show InChI InChI=1S/C32H38N2O3/c1-4-22(2)30(33)21-34(32(36)29-20-28(29)26-8-6-5-7-9-26)27-17-15-25(16-18-27)24-13-10-23(11-14-24)12-19-31(35)37-3/h5-11,13-18,22,28-30H,4,12,19-21,33H2,1-3H3/t22-,28-,29+,30+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 110n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064649
PNG
(CHEMBL3403772)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CO)NC(=O)[C@H](C)c1ccccc1
Show InChI InChI=1S/C23H31NO3/c1-4-8-17(2)16-27-21-13-11-20(12-14-21)22(15-25)24-23(26)18(3)19-9-6-5-7-10-19/h5-7,9-14,17-18,22,25H,4,8,15-16H2,1-3H3,(H,24,26)/t17?,18-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064645
PNG
(CHEMBL3403768)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CO)NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C23H31NO3/c1-4-8-17(2)16-27-21-13-11-20(12-14-21)22(15-25)24-23(26)18(3)19-9-6-5-7-10-19/h5-7,9-14,17-18,22,25H,4,8,15-16H2,1-3H3,(H,24,26)/t17?,18-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064747
PNG
(CHEMBL3403776)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CO)NC(=O)[C@@H](OC)c1ccccc1
Show InChI InChI=1S/C23H31NO4/c1-4-8-17(2)16-28-20-13-11-18(12-14-20)21(15-25)24-23(26)22(27-3)19-9-6-5-7-10-19/h5-7,9-14,17,21-22,25H,4,8,15-16H2,1-3H3,(H,24,26)/t17?,21-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 120n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065973
PNG
(CHEMBL3400268)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(OC)cc1
Show InChI InChI=1S/C29H34N2O2/c1-4-20(2)28(30)19-31(29(32)27-18-26(27)23-8-6-5-7-9-23)24-14-10-21(11-15-24)22-12-16-25(33-3)17-13-22/h5-17,20,26-28H,4,18-19,30H2,1-3H3/t20-,26-,27+,28+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 120n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065724
PNG
(CHEMBL3400225)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H31N3O/c1-3-19(2)25(28)18-30(27(31)24-17-23(24)26-11-7-8-16-29-26)22-14-12-21(13-15-22)20-9-5-4-6-10-20/h4-16,19,23-25H,3,17-18,28H2,1-2H3/t19-,23+,24+,25+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 130n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065721
PNG
(CHEMBL3400228)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H30N4O/c1-3-18(2)24(27)17-30(26(31)23-16-22(23)25-28-14-7-15-29-25)21-12-10-20(11-13-21)19-8-5-4-6-9-19/h4-15,18,22-24H,3,16-17,27H2,1-2H3/t18-,22+,23+,24+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 130n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Bioorg Med Chem Lett 25: 1443-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.038
BindingDB Entry DOI: 10.7270/Q2H133PZ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50209625
PNG
(CHEMBL3884002)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C23H30N4O2/c1-4-8-17(2)16-29-21-13-11-20(12-14-21)22(15-25-27-24)26-23(28)18(3)19-9-6-5-7-10-19/h5-7,9-14,17-18,22H,4,8,15-16H2,1-3H3,(H,26,28)/t17?,18-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 134n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measu...


Bioorg Med Chem 25: 805-812 (2017)


Article DOI: 10.1016/j.bmc.2016.11.058
BindingDB Entry DOI: 10.7270/Q26T0PNJ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50209625
PNG
(CHEMBL3884002)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C23H30N4O2/c1-4-8-17(2)16-29-21-13-11-20(12-14-21)22(15-25-27-24)26-23(28)18(3)19-9-6-5-7-10-19/h5-7,9-14,17-18,22H,4,8,15-16H2,1-3H3,(H,26,28)/t17?,18-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 135n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measu...


Bioorg Med Chem 25: 805-812 (2017)


Article DOI: 10.1016/j.bmc.2016.11.058
BindingDB Entry DOI: 10.7270/Q26T0PNJ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50209615
PNG
(CHEMBL3716055)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CO)NC(=O)[C@@H](CC)c1ccccc1
Show InChI InChI=1S/C24H33NO3/c1-4-9-18(3)17-28-21-14-12-20(13-15-21)23(16-26)25-24(27)22(5-2)19-10-7-6-8-11-19/h6-8,10-15,18,22-23,26H,4-5,9,16-17H2,1-3H3,(H,25,27)/t18?,22-,23-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 145n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measu...


Bioorg Med Chem 25: 805-812 (2017)


Article DOI: 10.1016/j.bmc.2016.11.058
BindingDB Entry DOI: 10.7270/Q26T0PNJ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50209615
PNG
(CHEMBL3716055)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CO)NC(=O)[C@@H](CC)c1ccccc1
Show InChI InChI=1S/C24H33NO3/c1-4-9-18(3)17-28-21-14-12-20(13-15-21)23(16-26)25-24(27)22(5-2)19-10-7-6-8-11-19/h6-8,10-15,18,22-23,26H,4-5,9,16-17H2,1-3H3,(H,25,27)/t18?,22-,23-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 145n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measu...


Bioorg Med Chem 25: 805-812 (2017)


Article DOI: 10.1016/j.bmc.2016.11.058
BindingDB Entry DOI: 10.7270/Q26T0PNJ
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064756
PNG
(CHEMBL3403785)
Show SMILES CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1
Show InChI InChI=1S/C23H31NO3/c1-5-16(2)15-27-20-11-12-21(17(3)13-20)22(14-25)24-23(26)18(4)19-9-7-6-8-10-19/h6-13,16,18,22,25H,5,14-15H2,1-4H3,(H,24,26)/t16-,18-,22-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 160n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50064744
PNG
(CHEMBL3403774)
Show SMILES CCCC(C)COc1ccc(cc1)[C@H](CO)NC(=O)c1ccccc1
Show InChI InChI=1S/C21H27NO3/c1-3-7-16(2)15-25-19-12-10-17(11-13-19)20(14-23)22-21(24)18-8-5-4-6-9-18/h4-6,8-13,16,20,23H,3,7,14-15H2,1-2H3,(H,22,24)/t16?,20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 170n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by H...


Bioorg Med Chem Lett 25: 1448-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.036
BindingDB Entry DOI: 10.7270/Q2G44RZH
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 177 total )  |  Next  |  Last  >>
Jump to: