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Compile Data Set for Download or QSAR

Found 3324 hits Enz. Inhib. hit(s) with Target = 'Progesterone receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))
BDBM50294702
PNG
(4-((2-chlorobenzyl)(1-(1-methyl-1H-tetrazol-5-yl)e...)
Show SMILES CC(N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1)c1nnnn1C
Show InChI InChI=1S/C18H16Cl2N6/c1-12(18-22-23-24-25(18)2)26(11-14-5-3-4-6-16(14)19)15-8-7-13(10-21)17(20)9-15/h3-9,12H,11H2,1-2H3
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n/an/an/an/a 0.0200n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay


Bioorg Med Chem Lett 19: 2637-41 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.146
BindingDB Entry DOI: 10.7270/Q2FX79GM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50294714
PNG
(4-((2-chlorobenzyl)(1-(4-methyl-4H-1,2,4-triazol-3...)
Show SMILES CCC(N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1)c1nncn1C
Show InChI InChI=1S/C20H19Cl2N5/c1-3-19(20-25-24-13-26(20)2)27(12-15-6-4-5-7-17(15)21)16-9-8-14(11-23)18(22)10-16/h4-10,13,19H,3,12H2,1-2H3
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n/an/an/an/a 0.0200n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay


Bioorg Med Chem Lett 19: 2637-41 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.146
BindingDB Entry DOI: 10.7270/Q2FX79GM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50294705
PNG
(4-((2-chlorobenzyl)(1-(1-methyl-1H-tetrazol-5-yl)p...)
Show SMILES CCC(N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1)c1nnnn1C
Show InChI InChI=1S/C19H18Cl2N6/c1-3-18(19-23-24-25-26(19)2)27(12-14-6-4-5-7-16(14)20)15-9-8-13(11-22)17(21)10-15/h4-10,18H,3,12H2,1-2H3
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n/an/an/an/a 0.0400n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay


Bioorg Med Chem Lett 19: 2637-41 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.146
BindingDB Entry DOI: 10.7270/Q2FX79GM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50294715
PNG
(4-((2-chlorobenzyl)(1-(4-methyl-4H-1,2,4-triazol-3...)
Show SMILES CCCC(N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1)c1nncn1C
Show InChI InChI=1S/C21H21Cl2N5/c1-3-6-20(21-26-25-14-27(21)2)28(13-16-7-4-5-8-18(16)22)17-10-9-15(12-24)19(23)11-17/h4-5,7-11,14,20H,3,6,13H2,1-2H3
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n/an/an/an/a 0.0500n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay


Bioorg Med Chem Lett 19: 2637-41 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.146
BindingDB Entry DOI: 10.7270/Q2FX79GM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50219260
PNG
(5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimida...)
Show SMILES Cn1c(ccc1-c1ccc2[nH]c(=S)n(C3CCCC3)c2c1)C#N
Show InChI InChI=1S/C18H18N4S/c1-21-14(11-19)7-9-16(21)12-6-8-15-17(10-12)22(18(23)20-15)13-4-2-3-5-13/h6-10,13H,2-5H2,1H3,(H,20,23)
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n/an/an/an/a 0.100n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor expressed in T47D cells by alkaline phosphatase assay


Bioorg Med Chem 15: 6556-64 (2007)


Article DOI: 10.1016/j.bmc.2007.07.011
BindingDB Entry DOI: 10.7270/Q2CV4HGN
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.100n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration on alkaline phosphatase activity in human T47D breast carcinoma cell line.


Bioorg Med Chem Lett 13: 1313-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00128-8
BindingDB Entry DOI: 10.7270/Q2SN09HR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/an/an/a 0.100n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Activation of progesterone receptor in human T47D cells after 20 hrs by PRE-tagged luciferase reporter gene assay


J Nat Prod 72: 1944-8 (2009)


Article DOI: 10.1021/np9004882
BindingDB Entry DOI: 10.7270/Q2R49RQR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50304978
PNG
((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-chloroben...)
Show SMILES COC(=O)N1CC[C@@H](C1)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19Cl2N3O2/c1-27-20(26)24-9-8-17(13-24)25(12-15-4-2-3-5-18(15)21)16-7-6-14(11-23)19(22)10-16/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
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n/an/an/an/a 0.100n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at PR in human T47D cells


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.120n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line


Bioorg Med Chem Lett 12: 787-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00025-2
BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375436
PNG
(CHEMBL260869)
Show SMILES COc1ccc(cn1)-c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](C[C@@H](C)[C@@H]2C(=O)C2CC2)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C35H39NO3/c1-20-16-30-28-13-10-24-17-26(37)12-14-27(24)32(28)29(18-35(30,2)33(20)34(38)23-8-9-23)22-6-4-21(5-7-22)25-11-15-31(39-3)36-19-25/h4-7,11,15,17,19-20,23,28-30,33H,8-10,12-14,16,18H2,1-3H3/t20-,28+,29-,30+,33-,35+/m1/s1
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n/an/an/an/a 0.120n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.120n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration against PR (progesterone receptor)


Bioorg Med Chem Lett 13: 1313-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00128-8
BindingDB Entry DOI: 10.7270/Q2SN09HR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonistic activity to the human progesterone receptor(hPR)assayed in CV-1 cells in cotransfection assay.


J Med Chem 41: 291-302 (1998)


Article DOI: 10.1021/jm9705768
BindingDB Entry DOI: 10.7270/Q29W0DMD
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Agonistic activity against human progesterone receptor expressed in CV-1 cells


J Med Chem 46: 4104-12 (2003)


Article DOI: 10.1021/jm020477g
BindingDB Entry DOI: 10.7270/Q2QZ29C6
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cell


J Med Chem 41: 4354-9 (1998)


Article DOI: 10.1021/jm980366a
BindingDB Entry DOI: 10.7270/Q2V40TB5
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)


Bioorg Med Chem Lett 8: 3365-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00608-8
BindingDB Entry DOI: 10.7270/Q2BC402X
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375821
PNG
(TANAPROGET)
Show SMILES Cn1c(ccc1-c1ccc2NC(=S)OC(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)
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n/an/an/an/a 0.150n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in co-transfected CV-1 cells.


J Med Chem 41: 303-10 (1998)


Article DOI: 10.1021/jm9705770
BindingDB Entry DOI: 10.7270/Q2RV0PC8
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells


J Med Chem 42: 1466-72 (1999)


Article DOI: 10.1021/jm980723h
BindingDB Entry DOI: 10.7270/Q2NK3FQ9
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375441
PNG
(CHEMBL260330)
Show SMILES COc1ccc(cn1)-c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CCC22CCCC2=O)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C34H37NO3/c1-33-19-28(22-7-5-21(6-8-22)24-10-14-31(38-2)35-20-24)32-26-13-11-25(36)18-23(26)9-12-27(32)29(33)15-17-34(33)16-3-4-30(34)37/h5-8,10,14,18,20,27-29H,3-4,9,11-13,15-17,19H2,1-2H3/t27-,28+,29-,33-,34?/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129152
PNG
((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Show SMILES C[C@H]1CC2[C@@H]3CC[C@](CC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C25H36O3/c1-15-12-19-20(23(4)9-6-18(28)13-22(15)23)7-10-24(5)21(19)8-11-25(24,17(3)27)14-16(2)26/h13,15,19-21H,6-12,14H2,1-5H3/t15-,19?,20-,21-,23+,24-,25-/m0/s1
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n/an/an/an/a 0.150n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50110516
PNG
(4-Methyl-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1sc(cc1C)C#N
Show InChI InChI=1S/C17H18N2OS/c1-10-7-13(9-18)21-16(10)12-5-6-15-14(8-12)17(3,4)20-11(2)19-15/h5-8,11,19H,1-4H3
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n/an/an/an/a 0.200n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line


Bioorg Med Chem Lett 12: 787-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00025-2
BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375438
PNG
(CHEMBL410923)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]2(C)[C@H]1C(=O)C1CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C34H37NO2/c1-20-16-30-28-13-11-24-17-26(36)12-14-27(24)31(28)29(18-34(30,2)32(20)33(37)23-9-10-23)22-7-5-21(6-8-22)25-4-3-15-35-19-25/h3-8,15,17,19-20,23,28-30,32H,9-14,16,18H2,1-2H3/t20-,28+,29-,30+,32-,34+/m1/s1
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n/an/an/an/a 0.200n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375442
PNG
(CHEMBL260764)
Show SMILES CC[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]2(C)[C@H]1C(=O)C1CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C35H39NO2/c1-3-21-18-31-29-14-12-25-17-27(37)13-15-28(25)32(29)30(19-35(31,2)33(21)34(38)24-10-11-24)23-8-6-22(7-9-23)26-5-4-16-36-20-26/h4-9,16-17,20-21,24,29-31,33H,3,10-15,18-19H2,1-2H3/t21-,29+,30-,31+,33-,35+/m1/s1
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n/an/an/an/a 0.230n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375425
PNG
(CHEMBL259879)
Show SMILES C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC21CCCC1=O)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C33H35NO2/c1-32-19-28(22-8-6-21(7-9-22)24-4-3-17-34-20-24)31-26-13-11-25(35)18-23(26)10-12-27(31)29(32)14-16-33(32)15-2-5-30(33)36/h3-4,6-9,17-18,20,27-29H,2,5,10-16,19H2,1H3/t27-,28+,29-,32-,33?/m0/s1
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n/an/an/an/a 0.290n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonistic activity at human progesterone receptor in CV-1 cells.


Bioorg Med Chem Lett 13: 2075-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00256-7
BindingDB Entry DOI: 10.7270/Q2P55P2M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50404221
PNG
(CHEMBL285139)
Show SMILES S=C1Nc2ccc(cc2C11CCCCC1)-c1csc(c1)C#N
Show InChI InChI=1S/C18H16N2S2/c19-10-14-8-13(11-22-14)12-4-5-16-15(9-12)18(17(21)20-16)6-2-1-3-7-18/h4-5,8-9,11H,1-3,6-7H2,(H,20,21)
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n/an/an/an/a 0.300n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells


Bioorg Med Chem Lett 13: 1317-20 (2003)


Article DOI: 10.1016/s0960-894x(03)00129-x
BindingDB Entry DOI: 10.7270/Q2WS8SNP
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50312005
PNG
(CHEMBL1087512 | Lecanindole B)
Show SMILES C[C@@]12[C@H](Cc3c1[nH]c1ccccc31)CC[C@@]1(O)C(C)(C)C(=O)CC[C@]21C
Show InChI InChI=1S/C23H29NO2/c1-20(2)18(25)10-11-21(3)22(4)14(9-12-23(20,21)26)13-16-15-7-5-6-8-17(15)24-19(16)22/h5-8,14,24,26H,9-13H2,1-4H3/t14-,21+,22+,23+/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Activation of progesterone receptor in human T47D cells after 20 hrs by PRE-tagged luciferase reporter gene assay


J Nat Prod 72: 1944-8 (2009)


Article DOI: 10.1021/np9004882
BindingDB Entry DOI: 10.7270/Q2R49RQR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298208
PNG
((S)-2-chloro-4-((2-chloro-5-fluorobenzyl)(1-ethyl-...)
Show SMILES CCN1C[C@H](CC1=O)N(Cc1cc(F)ccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2FN3O/c1-2-25-12-17(9-20(25)27)26(11-14-7-15(23)4-6-18(14)21)16-5-3-13(10-24)19(22)8-16/h3-8,17H,2,9,11-12H2,1H3/t17-/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298206
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-methyl-5-oxopyr...)
Show SMILES CN1C[C@H](CC1=O)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C19H17Cl2N3O/c1-23-12-16(9-19(23)25)24(11-14-4-2-3-5-17(14)20)15-7-6-13(10-22)18(21)8-15/h2-8,16H,9,11-12H2,1H3/t16-/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298207
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-isopropyl-5-oxo...)
Show SMILES CC(C)N1C[C@H](CC1=O)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H21Cl2N3O/c1-14(2)25-13-18(10-21(25)27)26(12-16-5-3-4-6-19(16)22)17-8-7-15(11-24)20(23)9-17/h3-9,14,18H,10,12-13H2,1-2H3/t18-/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50404182
PNG
(CHEMBL25463)
Show SMILES CC1(CC=C)OC(=S)Nc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClNOS/c1-3-9-18(2)15-11-13(12-5-4-6-14(19)10-12)7-8-16(15)20-17(22)21-18/h3-8,10-11H,1,9H2,2H3,(H,20,22)
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n/an/an/an/a 0.300n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration on alkaline phosphatase activity in human T47D breast carcinoma cell line.


Bioorg Med Chem Lett 13: 1313-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00128-8
BindingDB Entry DOI: 10.7270/Q2SN09HR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.330n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells


J Med Chem 42: 1466-72 (1999)


Article DOI: 10.1021/jm980723h
BindingDB Entry DOI: 10.7270/Q2NK3FQ9
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.330n/an/an/an/a



Ligand Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Agonistic activity against human progesterone receptor in T47D breast cancer cells


J Med Chem 46: 4104-12 (2003)


Article DOI: 10.1021/jm020477g
BindingDB Entry DOI: 10.7270/Q2QZ29C6
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50110501
PNG
(3-Fluoro-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H17FN2O/c1-11-21-17-5-4-13(9-16(17)18(2,3)22-11)14-6-12(10-20)7-15(19)8-14/h4-9,11,21H,1-3H3
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n/an/an/an/a 0.350n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line


Bioorg Med Chem Lett 12: 787-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00025-2
BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50110520
PNG
(4-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1csc(c1)C#N
Show InChI InChI=1S/C16H16N2OS/c1-10-18-15-5-4-11(7-14(15)16(2,3)19-10)12-6-13(8-17)20-9-12/h4-7,9-10,18H,1-3H3
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n/an/an/an/a 0.350n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line


Bioorg Med Chem Lett 12: 787-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00025-2
BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375429
PNG
(CHEMBL438593)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]2(C)[C@H]1C(=O)C1CC1)c1ccc(cc1)-c1cccnn1
Show InChI InChI=1S/C33H36N2O2/c1-19-16-28-26-13-11-23-17-24(36)12-14-25(23)30(26)27(18-33(28,2)31(19)32(37)22-9-10-22)20-5-7-21(8-6-20)29-4-3-15-34-35-29/h3-8,15,17,19,22,26-28,31H,9-14,16,18H2,1-2H3/t19-,26+,27-,28+,31-,33+/m1/s1
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n/an/an/an/a 0.360n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50126158
PNG
(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=S)C3(CCCCC3)c2c1)C#N
Show InChI InChI=1S/C20H17FN2S/c21-16-9-13(12-22)8-15(10-16)14-4-5-18-17(11-14)20(19(24)23-18)6-2-1-3-7-20/h4-5,8-11H,1-3,6-7H2,(H,23,24)
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n/an/an/an/a 0.360n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells


Bioorg Med Chem Lett 13: 1317-20 (2003)


Article DOI: 10.1016/s0960-894x(03)00129-x
BindingDB Entry DOI: 10.7270/Q2WS8SNP
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50126111
PNG
(4-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1(C)OC(=S)Nc2ccc(cc12)-c1csc(c1)C#N
Show InChI InChI=1S/C15H12N2OS2/c1-15(2)12-6-9(10-5-11(7-16)20-8-10)3-4-13(12)17-14(19)18-15/h3-6,8H,1-2H3,(H,17,19)
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n/an/an/an/a 0.380n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration against PR (progesterone receptor)


Bioorg Med Chem Lett 13: 1313-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00128-8
BindingDB Entry DOI: 10.7270/Q2SN09HR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50126111
PNG
(4-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1(C)OC(=S)Nc2ccc(cc12)-c1csc(c1)C#N
Show InChI InChI=1S/C15H12N2OS2/c1-15(2)12-6-9(10-5-11(7-16)20-8-10)3-4-13(12)17-14(19)18-15/h3-6,8H,1-2H3,(H,17,19)
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n/an/an/an/a 0.400n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory activity against GR (glucocorticoid receptor)


Bioorg Med Chem Lett 13: 1313-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00128-8
BindingDB Entry DOI: 10.7270/Q2SN09HR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50264311
PNG
(5-(5-(furan-2-yl)-5-methyl-2-oxo-1,2,3,5-tetrahydr...)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)COC(C)(c3ccco3)c2c1)C#N
Show InChI InChI=1S/C20H17N3O3/c1-20(18-4-3-9-25-18)15-10-13(17-8-6-14(11-21)23(17)2)5-7-16(15)22-19(24)12-26-20/h3-10H,12H2,1-2H3,(H,22,24)
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n/an/an/an/a 0.400n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cells


Bioorg Med Chem Lett 18: 5015-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.015
BindingDB Entry DOI: 10.7270/Q25B03D7
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.400n/an/an/an/a



Ligand Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human progesterone receptor in human T47D cells assessed as alkaline phosphatase activity


J Med Chem 51: 3696-9 (2008)


Article DOI: 10.1021/jm8004256
BindingDB Entry DOI: 10.7270/Q2H131VC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304987
PNG
((S)-4-((2-bromobenzyl)(1-propionylpyrrolidin-3-yl)...)
Show SMILES CCC(=O)N1CC[C@@H](C1)N(Cc1ccccc1Br)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H21BrClN3O/c1-2-21(27)25-10-9-18(14-25)26(13-16-5-3-4-6-19(16)22)17-8-7-15(12-24)20(23)11-17/h3-8,11,18H,2,9-10,13-14H2,1H3/t18-/m0/s1
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n/an/an/an/a 0.400n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at PR in human T47D cells


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50243440
PNG
((-)-7,9-difluoro-5-(6-methyl-7-oxa-bicyclo[4.1.0]h...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)cc(F)c4O[C@@H]([C@H]4CCC[C@@]5(C)O[C@@H]45)c3c12
Show InChI InChI=1S/C26H27F2NO2/c1-13-12-25(2,3)29-19-8-7-15-17-10-14(27)11-18(28)22(17)30-23(21(15)20(13)19)16-6-5-9-26(4)24(16)31-26/h7-8,10-12,16,23-24,29H,5-6,9H2,1-4H3/t16-,23+,24+,26-/m1/s1
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n/an/an/an/a 0.400n/an/an/an/a



Ligand Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human progesterone receptor


J Med Chem 51: 3696-9 (2008)


Article DOI: 10.1021/jm8004256
BindingDB Entry DOI: 10.7270/Q2H131VC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50404206
PNG
(CHEMBL280613)
Show SMILES CC1(C)OC(=S)Nc2ccc(cc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H14N2OS/c1-17(2)14-9-13(6-7-15(14)19-16(21)20-17)12-5-3-4-11(8-12)10-18/h3-9H,1-2H3,(H,19,21)
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n/an/an/an/a 0.400n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration on alkaline phosphatase activity in human T47D breast carcinoma cell line.


Bioorg Med Chem Lett 13: 1313-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00128-8
BindingDB Entry DOI: 10.7270/Q2SN09HR
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375439
PNG
(CHEMBL410304)
Show SMILES C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(C)C(=O)C1CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C34H37NO2/c1-33(32(37)23-9-10-23)16-15-30-28-13-11-24-18-26(36)12-14-27(24)31(28)29(19-34(30,33)2)22-7-5-21(6-8-22)25-4-3-17-35-20-25/h3-8,17-18,20,23,28-30H,9-16,19H2,1-2H3/t28-,29+,30-,33+,34-/m0/s1
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n/an/an/an/a 0.490n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375432
PNG
(CHEMBL258521)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]2(C)[C@H]1C(=O)C1CC1)c1ccc(cc1)-c1ccc(F)nc1
Show InChI InChI=1S/C34H36FNO2/c1-19-15-29-27-12-9-23-16-25(37)11-13-26(23)31(27)28(17-34(29,2)32(19)33(38)22-7-8-22)21-5-3-20(4-6-21)24-10-14-30(35)36-18-24/h3-6,10,14,16,18-19,22,27-29,32H,7-9,11-13,15,17H2,1-2H3/t19-,27+,28-,29+,32-,34+/m1/s1
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n/an/an/an/a 0.490n/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Agonist activity at human PRB expressed in CHO cells


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50294703
PNG
(4-((2-chlorobenzyl)(1-(4-methyl-4H-1,2,4-triazol-3...)
Show SMILES CC(N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1)c1nncn1C
Show InChI InChI=1S/C19H17Cl2N5/c1-13(19-24-23-12-25(19)2)26(11-15-5-3-4-6-17(15)20)16-8-7-14(10-22)18(21)9-16/h3-9,12-13H,11H2,1-2H3
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n/an/an/an/a 0.5n/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cells by alkaline phosphatase release based reporter gene assay


Bioorg Med Chem Lett 19: 2637-41 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.146
BindingDB Entry DOI: 10.7270/Q2FX79GM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298032
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-(cyanomethyl)py...)
Show SMILES Clc1ccccc1CN([C@H]1CCN(CC#N)C1)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2N4/c21-19-4-2-1-3-16(19)13-26(18-7-9-25(14-18)10-8-23)17-6-5-15(12-24)20(22)11-17/h1-6,11,18H,7,9-10,13-14H2/t18-/m0/s1
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GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at PR expressed in african green monkey CV-1 cells by luciferase reporter assay


Bioorg Med Chem Lett 19: 4777-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.055
BindingDB Entry DOI: 10.7270/Q2TB16XG
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50219261
PNG
(5-(3-cyclobutyl-2-thioxo-2,3-dihydro-1H-benzimidaz...)
Show SMILES Cn1c(ccc1-c1ccc2[nH]c(=S)n(C3CCC3)c2c1)C#N
Show InChI InChI=1S/C17H16N4S/c1-20-13(10-18)6-8-15(20)11-5-7-14-16(9-11)21(17(22)19-14)12-3-2-4-12/h5-9,12H,2-4H2,1H3,(H,19,22)
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n/an/an/an/a 0.5n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor expressed in T47D cells by alkaline phosphatase assay


Bioorg Med Chem 15: 6556-64 (2007)


Article DOI: 10.1016/j.bmc.2007.07.011
BindingDB Entry DOI: 10.7270/Q2CV4HGN
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells


Bioorg Med Chem Lett 13: 1317-20 (2003)


Article DOI: 10.1016/s0960-894x(03)00129-x
BindingDB Entry DOI: 10.7270/Q2WS8SNP
More data for this
Ligand-Target Pair
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