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Compile Data Set for Download or QSAR

Found 1262 hits Enz. Inhib. hit(s) with Target = 'Prostanoid EP2 Receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156541
PNG
(CHEMBL3794302)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(c1)C(F)(F)F)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H19ClF3NO5S/c21-13-3-1-9(5-12(13)20(22,23)24)29-7-11-10-2-4-16(30-17(10)6-15(11)26)18-25-14(8-31-18)19(27)28/h1,3,5,8,10-11,15-17,26H,2,4,6-7H2,(H,27,28)/t10-,11-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.110n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156474
PNG
(CHEMBL3793515)
Show SMILES Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C20H22ClNO5S/c1-10-6-11(2-4-14(10)21)26-8-13-12-3-5-17(27-18(12)7-16(13)23)19-22-15(9-28-19)20(24)25/h2,4,6,9,12-13,16-18,23H,3,5,7-8H2,1H3,(H,24,25)/t12-,13-,16+,17-,18+/m1/s1
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n/an/an/an/a 0.140n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156533
PNG
(CHEMBL3794016)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)cc(C)c1Cl
Show InChI InChI=1S/C21H24ClNO5S/c1-10-5-12(6-11(2)19(10)22)27-8-14-13-3-4-17(28-18(13)7-16(14)24)20-23-15(9-29-20)21(25)26/h5-6,9,13-14,16-18,24H,3-4,7-8H2,1-2H3,(H,25,26)/t13-,14-,16-,17-,18+/m1/s1
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n/an/an/an/a 0.170n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156532
PNG
(CHEMBL3793862)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cc(Cl)c(Cl)cc1Cl)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H18Cl3NO5S/c20-10-3-12(22)17(4-11(10)21)27-6-9-8-1-2-15(28-16(8)5-14(9)24)18-23-13(7-29-18)19(25)26/h3-4,7-9,14-16,24H,1-2,5-6H2,(H,25,26)/t8-,9-,14-,15-,16+/m1/s1
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n/an/an/an/a 0.200n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Rattus norvegicus)
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 0.200n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release


Bioorg Med Chem Lett 19: 2075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Rattus norvegicus)
BDBM50293492
PNG
(3-(3-((N-(4-tert-butylbenzyl)phenylsulfonamido)met...)
Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C27H31NO4S/c1-27(2,3)24-15-12-22(13-16-24)19-28(33(31,32)25-10-5-4-6-11-25)20-23-9-7-8-21(18-23)14-17-26(29)30/h4-13,15-16,18H,14,17,19-20H2,1-3H3,(H,29,30)
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n/an/an/an/a 0.200n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release


Bioorg Med Chem Lett 19: 2075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156531
PNG
(CHEMBL3792632)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(Cl)c1Cl)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H18Cl3NO5S/c20-10-2-4-13(17(22)16(10)21)27-6-9-8-1-3-14(28-15(8)5-12(9)24)18-23-11(7-29-18)19(25)26/h2,4,7-9,12,14-15,24H,1,3,5-6H2,(H,25,26)/t8-,9-,12-,14-,15+/m1/s1
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n/an/an/an/a 0.210n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Rattus norvegicus)
BDBM50293496
PNG
(2-(3-((N-(4-tert-butylbenzyl)pyridine-3-sulfonamid...)
Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(OCC(O)=O)c2)S(=O)(=O)c2cccnc2)cc1
Show InChI InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)
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n/an/an/an/a 0.300n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release


Bioorg Med Chem Lett 19: 2075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50138101
PNG
(CHEMBL3754586)
Show SMILES CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H30N2O4S2/c1-3-4-5-14(2)12-16(23)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h6,8,13-16,23H,3-5,7,9-12H2,1-2H3,(H,25,26)/b8-6+/t14-,15-,16+/m0/s1
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n/an/an/an/a 0.390n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50169613
PNG
(CHEMBL3806284)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccccc1C(F)(F)F)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)12-3-1-2-4-15(12)28-8-11-10-5-6-16(29-17(10)7-14(11)25)18-24-13(9-30-18)19(26)27/h1-4,9-11,14,16-17,25H,5-8H2,(H,26,27)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 0.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156540
PNG
(CHEMBL3793802)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(Cl)c1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H19Cl2NO5S/c20-12-3-1-9(5-13(12)21)26-7-11-10-2-4-16(27-17(10)6-15(11)23)18-22-14(8-28-18)19(24)25/h1,3,5,8,10-11,15-17,23H,2,4,6-7H2,(H,24,25)/t10-,11-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.570n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156538
PNG
(CHEMBL3794466)
Show SMILES CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C21H24ClNO5S/c1-2-11-7-12(3-5-15(11)22)27-9-14-13-4-6-18(28-19(13)8-17(14)24)20-23-16(10-29-20)21(25)26/h3,5,7,10,13-14,17-19,24H,2,4,6,8-9H2,1H3,(H,25,26)/t13-,14-,17-,18-,19+/m1/s1
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n/an/an/an/a 0.680n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156539
PNG
(CHEMBL3793892)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C20H22ClNO5S/c1-10-6-11(2-4-14(10)21)26-8-13-12-3-5-17(27-18(12)7-16(13)23)19-22-15(9-28-19)20(24)25/h2,4,6,9,12-13,16-18,23H,3,5,7-8H2,1H3,(H,24,25)/t12-,13-,16-,17-,18+/m1/s1
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n/an/an/an/a 0.690n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50169609
PNG
(CHEMBL3805981)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cccc(OC(F)(F)F)c1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H20F3NO6S/c21-20(22,23)30-11-3-1-2-10(6-11)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-31-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156543
PNG
(CHEMBL3793045)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cccc(c1)C(F)(F)F)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)10-2-1-3-11(6-10)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-30-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156543
PNG
(CHEMBL3793045)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cccc(c1)C(F)(F)F)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)10-2-1-3-11(6-10)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-30-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204978
PNG
(US9249085, I(al))
Show SMILES COc1c(C)cc(cc1CNc1c(C)ccc(OCC(O)=O)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO4/c1-15-8-9-22(31-14-23(28)29)17(3)24(15)27-13-20-11-19(10-16(2)25(20)30-4)18-6-5-7-21(26)12-18/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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n/an/an/an/a 0.900n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50138102
PNG
(CHEMBL3752377)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H30N2O4S2/c1-4-5-10-20(2,3)16(23)8-6-14-7-9-17(24)22(14)11-12-27-19-21-15(13-28-19)18(25)26/h6,8,13-14,16,23H,4-5,7,9-12H2,1-3H3,(H,25,26)/b8-6+/t14-,16+/m0/s1
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n/an/an/an/a 0.910n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204973
PNG
(US9249085, I(ag))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-21(30-13-22(28)29)16(3)24(14)27-12-19-10-18(9-15(2)23(19)26)17-5-4-6-20(25)11-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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n/an/an/an/a<1n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204981
PNG
(US9249085, I(ao))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(O)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22FNO4/c1-14-6-7-21(29-13-22(27)28)15(2)23(14)25-12-16-8-18(11-20(26)9-16)17-4-3-5-19(24)10-17/h3-11,25-26H,12-13H2,1-2H3,(H,27,28)
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n/an/an/an/a 1n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Rattus norvegicus)
BDBM50293495
PNG
(3-(3-((N-(4-tert-butylbenzyl)thiazole-2-sulfonamid...)
Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(=O)(=O)c2nccs2)cc1
Show InChI InChI=1S/C24H28N2O4S2/c1-24(2,3)21-10-7-19(8-11-21)16-26(32(29,30)23-25-13-14-31-23)17-20-6-4-5-18(15-20)9-12-22(27)28/h4-8,10-11,13-15H,9,12,16-17H2,1-3H3,(H,27,28)
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n/an/an/an/a 1.10n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release


Bioorg Med Chem Lett 19: 2075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1CCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 1.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156536
PNG
(CHEMBL3794585)
Show SMILES COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C20H22ClNO6S/c1-26-18-6-10(2-4-13(18)21)27-8-12-11-3-5-16(28-17(11)7-15(12)23)19-22-14(9-29-19)20(24)25/h2,4,6,9,11-12,15-17,23H,3,5,7-8H2,1H3,(H,24,25)/t11-,12-,15-,16-,17+/m1/s1
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n/an/an/an/a 1.80n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50016952
PNG
(CHEMBL3286796)
Show SMILES O[C@@H](C\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1C\C=C/CCCC(O)=O)C1(CC=C)CCC1
Show InChI InChI=1S/C23H35ClO4/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h2-3,5,7,10,17-21,25-26H,1,4,6,8-9,11-16H2,(H,27,28)/b5-3-,10-7+/t17-,18-,19-,20-,21+/m1/s1
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n/an/an/an/a 1.80n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


J Med Chem 57: 4454-65 (2014)


Article DOI: 10.1021/jm401431x
BindingDB Entry DOI: 10.7270/Q2CR5VXZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 1.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263352
PNG
(US9546162, 10)
Show SMILES COc1cccc(CCN2Cc3cccc(CCc4ccc(cc4)C(O)=O)c3C2)c1
Show InChI InChI=1S/C26H27NO3/c1-30-24-7-2-4-20(16-24)14-15-27-17-23-6-3-5-21(25(23)18-27)11-8-19-9-12-22(13-10-19)26(28)29/h2-7,9-10,12-13,16H,8,11,14-15,17-18H2,1H3,(H,28,29)
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18n/an/an/a 2n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204983
PNG
(US9249085, I(aq))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H19F4NO3/c1-12-7-15(14-3-4-17(24)19(26)9-14)8-16(13(12)2)10-28-23-18(25)5-6-20(22(23)27)31-11-21(29)30/h3-9,28H,10-11H2,1-2H3,(H,29,30)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204970
PNG
(US9249085, I(ad))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(22(13)26)11-27-23-14(2)20(7-6-19(23)25)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204977
PNG
(US9249085, I(ak))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO3/c1-15-8-9-23(30-14-24(28)29)18(4)25(15)27-13-21-11-20(10-16(2)17(21)3)19-6-5-7-22(26)12-19/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156537
PNG
(CHEMBL3793020)
Show SMILES CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C22H26ClNO5S/c1-11(2)14-7-12(3-5-16(14)23)28-9-15-13-4-6-19(29-20(13)8-18(15)25)21-24-17(10-30-21)22(26)27/h3,5,7,10-11,13,15,18-20,25H,4,6,8-9H2,1-2H3,(H,26,27)/t13-,15-,18-,19-,20+/m1/s1
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n/an/an/an/a 2n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204962
PNG
(US9249085, I(v))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(14(13)2)11-27-23-19(25)6-7-20(22(23)26)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Mus musculus (Mouse))
BDBM50101822
PNG
((Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Show SMILES CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17-,19-/m1/s1
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n/an/an/an/a 2.10n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Prostanoid IP receptor in CHO cells.


Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.10n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


J Med Chem 57: 4454-65 (2014)


Article DOI: 10.1021/jm401431x
BindingDB Entry DOI: 10.7270/Q2CR5VXZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156529
PNG
(CHEMBL3794226)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2ccc(o2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C21H23ClO6/c1-11-8-12(2-4-15(11)22)26-10-14-13-3-5-17(28-20(13)9-16(14)23)18-6-7-19(27-18)21(24)25/h2,4,6-8,13-14,16-17,20,23H,3,5,9-10H2,1H3,(H,24,25)/t13-,14-,16-,17-,20+/m1/s1
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n/an/an/an/a 2.20n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Rattus norvegicus)
BDBM50293493
PNG
(3-(3-((N-(4-tert-butylbenzyl)pyridine-2-sulfonamid...)
Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(=O)(=O)c2ccccn2)cc1
Show InChI InChI=1S/C26H30N2O4S/c1-26(2,3)23-13-10-21(11-14-23)18-28(33(31,32)24-9-4-5-16-27-24)19-22-8-6-7-20(17-22)12-15-25(29)30/h4-11,13-14,16-17H,12,15,18-19H2,1-3H3,(H,29,30)
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n/an/an/an/a 2.30n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release


Bioorg Med Chem Lett 19: 2075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156533
PNG
(CHEMBL3794016)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)cc(C)c1Cl
Show InChI InChI=1S/C21H24ClNO5S/c1-10-5-12(6-11(2)19(10)22)27-8-14-13-3-4-17(28-18(13)7-16(14)24)20-23-15(9-29-20)21(25)26/h5-6,9,13-14,16-18,24H,3-4,7-8H2,1-2H3,(H,25,26)/t13-,14-,16-,17-,18+/m1/s1
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n/an/an/an/a 2.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156531
PNG
(CHEMBL3792632)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(Cl)c1Cl)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H18Cl3NO5S/c20-10-2-4-13(17(22)16(10)21)27-6-9-8-1-3-14(28-15(8)5-12(9)24)18-23-11(7-29-18)19(25)26/h2,4,7-9,12,14-15,24H,1,3,5-6H2,(H,25,26)/t8-,9-,12-,14-,15+/m1/s1
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n/an/an/an/a 2.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Mus musculus (Mouse))
BDBM50101853
PNG
((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50016953
PNG
(TAPRENEPAG | Taprenepag)
Show SMILES OC(=O)COc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)c1
Show InChI InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)
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n/an/an/an/a 2.80n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


J Med Chem 57: 4454-65 (2014)


Article DOI: 10.1021/jm401431x
BindingDB Entry DOI: 10.7270/Q2CR5VXZ
More data for this
Ligand-Target Pair
Prostanoid EP2 receptor


(Mus musculus (Mouse))
BDBM50101830
PNG
((Z)-7-{(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-4-(1-ethy...)
Show SMILES CCC1(CCC1)[C@@H](O)C\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H35ClO4/c1-2-22(13-8-14-22)20(25)11-7-10-17-16(18(23)15-19(17)24)9-5-3-4-6-12-21(26)27/h3,5,7,10,16-20,24-25H,2,4,6,8-9,11-15H2,1H3,(H,26,27)/b5-3-,10-7+/t16-,17-,18-,19-,20+/m1/s1
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n/an/an/an/a 2.80n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50138052
PNG
(CHEMBL3751951)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCCCF)CCC1
Show InChI InChI=1S/C20H27FN2O5S2/c21-9-2-1-6-20(7-3-8-20)16(24)5-4-14-12-28-19(27)23(14)10-11-29-18-22-15(13-30-18)17(25)26/h4-5,13-14,16,24H,1-3,6-12H2,(H,25,26)/b5-4+/t14-,16+/m0/s1
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n/an/an/an/a 2.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50156535
PNG
(CHEMBL3793797)
Show SMILES Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)cc1C
Show InChI InChI=1S/C21H25NO5S/c1-11-3-4-13(7-12(11)2)26-9-15-14-5-6-18(27-19(14)8-17(15)23)20-22-16(10-28-20)21(24)25/h3-4,7,10,14-15,17-19,23H,5-6,8-9H2,1-2H3,(H,24,25)/t14-,15-,17-,18-,19+/m1/s1
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n/an/an/an/a 2.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Bioorg Med Chem Lett 26: 2446-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.110
BindingDB Entry DOI: 10.7270/Q2H41T90
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50138051
PNG
(CHEMBL3753221)
Show SMILES CCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H28N2O5S2/c1-2-3-7-20(8-4-9-20)16(23)6-5-14-12-27-19(26)22(14)10-11-28-18-21-15(13-29-18)17(24)25/h5-6,13-14,16,23H,2-4,7-12H2,1H3,(H,24,25)/b6-5+/t14-,16+/m0/s1
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n/an/an/an/a 2.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204989
PNG
(US9249085, I(aw))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50373944
PNG
(CHEMBL272277)
Show SMILES CCCCC1(CCC1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H33NO4/c1-2-3-14-24(15-4-16-24)21(26)11-9-20-10-12-22(27)25(20)17-13-18-5-7-19(8-6-18)23(28)29/h5-9,11,20-21,26H,2-4,10,12-17H2,1H3,(H,28,29)/b11-9+/t20-,21-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



EMD-Serono Research Institute, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor by cAMP assay


Bioorg Med Chem Lett 18: 821-4 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.020
BindingDB Entry DOI: 10.7270/Q2W096SW
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204967
PNG
(US9249085, I(aa))
Show SMILES Cc1c(F)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-15(7-14(9-18(12)25)13-3-2-4-16(23)8-13)10-27-22-17(24)5-6-19(21(22)26)30-11-20(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204971
PNG
(US9249085, I(ae))
Show SMILES Cc1cc(CNc2c(F)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H21F2NO3/c1-14-8-16(10-18(9-14)17-4-3-5-19(24)11-17)12-26-23-15(2)21(7-6-20(23)25)29-13-22(27)28/h3-11,26H,12-13H2,1-2H3,(H,27,28)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204979
PNG
(US9249085, I(am))
Show SMILES Cc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)c(F)c(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-9-18(23(26)20(10-14)17-5-4-6-19(25)11-17)12-27-24-15(2)7-8-21(16(24)3)30-13-22(28)29/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM204982
PNG
(US9249085, I(ap))
Show SMILES COc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H24FNO4/c1-15-7-8-22(30-14-23(27)28)16(2)24(15)26-13-17-9-19(12-21(10-17)29-3)18-5-4-6-20(25)11-18/h4-12,26H,13-14H2,1-3H3,(H,27,28)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50169614
PNG
(CHEMBL3805767)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccccc1Cl)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H20ClNO5S/c20-12-3-1-2-4-15(12)25-8-11-10-5-6-16(26-17(10)7-14(11)22)18-21-13(9-27-18)19(23)24/h1-4,9-11,14,16-17,22H,5-8H2,(H,23,24)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 3.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
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