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Compile Data Set for Download or QSAR

Found 1502 hits Enz. Inhib. hit(s) with Target = 'Prostanoid EP3 Receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206016
PNG
(CHEMBL3889508)
Show SMILES CS(=O)(=O)NC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COc1ccccc1
Show InChI InChI=1S/C23H33NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-22,25-27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2-,14-13+/t17-,19-,20-,21+,22-/m1/s1
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n/an/an/an/a 0.340n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@H](CC[C@H]12)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 0.800n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206028
PNG
(CHEMBL3967903)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H28O6/c23-16(15-28-17-8-4-3-5-9-17)12-13-19-18(20(24)14-21(19)25)10-6-1-2-7-11-22(26)27/h1,3-6,8-9,12-13,16,18-19,21,23,25H,2,7,10-11,14-15H2,(H,26,27)/b6-1-,13-12+/t16-,18-,19-,21-/m1/s1
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n/an/an/an/a 0.890n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206022
PNG
(CHEMBL3947086)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2OC[C@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C23H32O6/c24-17(15-28-18-6-2-1-3-7-18)10-12-19-20-11-9-16(5-4-8-23(26)27)14-29-22(20)13-21(19)25/h1-3,6-7,10,12,16-17,19-22,24-25H,4-5,8-9,11,13-15H2,(H,26,27)/b12-10+/t16-,17-,19-,20-,21-,22+/m1/s1
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n/an/an/an/a 2.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 3.60n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138051
PNG
(CHEMBL3753221)
Show SMILES CCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H28N2O5S2/c1-2-3-7-20(8-4-9-20)16(23)6-5-14-12-27-19(26)22(14)10-11-28-18-21-15(13-29-18)17(24)25/h5-6,13-14,16,23H,2-4,7-12H2,1H3,(H,24,25)/b6-5+/t14-,16+/m0/s1
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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206018
PNG
(CHEMBL3967855)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2OC[C@@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C23H32O6/c24-17(15-28-18-6-2-1-3-7-18)10-12-19-20-11-9-16(5-4-8-23(26)27)14-29-22(20)13-21(19)25/h1-3,6-7,10,12,16-17,19-22,24-25H,4-5,8-9,11,13-15H2,(H,26,27)/b12-10+/t16-,17+,19+,20+,21+,22-/m0/s1
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n/an/an/an/a 4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206020
PNG
(CHEMBL3982726)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C22H30O6/c23-15(14-27-16-5-2-1-3-6-16)9-11-18-19-12-10-17(7-4-8-22(25)26)28-21(19)13-20(18)24/h1-3,5-6,9,11,15,17-21,23-24H,4,7-8,10,12-14H2,(H,25,26)/b11-9+/t15-,17-,18-,19-,20-,21+/m1/s1
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n/an/an/an/a 4.10n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138050
PNG
(CHEMBL3752406)
Show SMILES CC(C)(CCCCF)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H27FN2O5S2/c1-19(2,7-3-4-8-20)15(23)6-5-13-11-27-18(26)22(13)9-10-28-17-21-14(12-29-17)16(24)25/h5-6,12-13,15,23H,3-4,7-11H2,1-2H3,(H,24,25)/b6-5+/t13-,15+/m0/s1
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n/an/an/an/a 4.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138046
PNG
(CHEMBL3752435)
Show SMILES CC(C)(C)CCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C22H32N2O5S2/c1-21(2,3)9-10-22(7-4-8-22)17(25)6-5-15-13-29-20(28)24(15)11-12-30-19-23-16(14-31-19)18(26)27/h5-6,14-15,17,25H,4,7-13H2,1-3H3,(H,26,27)/b6-5+/t15-,17+/m0/s1
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n/an/an/an/a 6.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138044
PNG
(CHEMBL3754197)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCC2CCCCC2)CCC1
Show InChI InChI=1S/C24H34N2O5S2/c27-20(24(10-4-11-24)12-9-17-5-2-1-3-6-17)8-7-18-15-31-23(30)26(18)13-14-32-22-25-19(16-33-22)21(28)29/h7-8,16-18,20,27H,1-6,9-15H2,(H,28,29)/b8-7+/t18-,20+/m0/s1
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n/an/an/an/a 7.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138102
PNG
(CHEMBL3752377)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H30N2O4S2/c1-4-5-10-20(2,3)16(23)8-6-14-7-9-17(24)22(14)11-12-27-19-21-15(13-28-19)18(25)26/h6,8,13-14,16,23H,4-5,7,9-12H2,1-3H3,(H,25,26)/b8-6+/t14-,16+/m0/s1
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n/an/an/an/a 8.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138052
PNG
(CHEMBL3751951)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCCCF)CCC1
Show InChI InChI=1S/C20H27FN2O5S2/c21-9-2-1-6-20(7-3-8-20)16(24)5-4-14-12-28-19(27)23(14)10-11-29-18-22-15(13-30-18)17(25)26/h4-5,13-14,16,24H,1-3,6-12H2,(H,25,26)/b5-4+/t14-,16+/m0/s1
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n/an/an/an/a 10n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206021
PNG
(CHEMBL3904644)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2OCC(CCCCC(O)=O)=CC[C@H]12
Show InChI InChI=1S/C24H32O6/c25-18(16-29-19-7-2-1-3-8-19)11-13-20-21-12-10-17(6-4-5-9-24(27)28)15-30-23(21)14-22(20)26/h1-3,7-8,10-11,13,18,20-23,25-26H,4-6,9,12,14-16H2,(H,27,28)/b13-11+/t18-,20-,21-,22-,23+/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138045
PNG
(CHEMBL3753268)
Show SMILES CC#CCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H24N2O5S2/c1-2-3-7-20(8-4-9-20)16(23)6-5-14-12-27-19(26)22(14)10-11-28-18-21-15(13-29-18)17(24)25/h5-6,13-14,16,23H,4,7-12H2,1H3,(H,24,25)/b6-5+/t14-,16+/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206026
PNG
(CHEMBL3920347)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@@H](CCC(O)=O)CCC[C@H]12
Show InChI InChI=1S/C22H30O6/c23-15(14-27-16-5-2-1-3-6-16)9-11-18-19-8-4-7-17(10-12-22(25)26)28-21(19)13-20(18)24/h1-3,5-6,9,11,15,17-21,23-24H,4,7-8,10,12-14H2,(H,25,26)/b11-9+/t15-,17-,18-,19-,20-,21+/m1/s1
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n/an/an/an/a 18n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35861
PNG
(phenylpropanoic acid analogue, 5)
Show SMILES OC(=O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H24N2O3/c28-25(29)11-10-22-9-7-20(18-27-14-3-13-26-27)17-24(22)30-15-12-19-6-8-21-4-1-2-5-23(21)16-19/h1-9,13-14,16-17H,10-12,15,18H2,(H,28,29)
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12n/an/an/a 22n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138053
PNG
(CHEMBL3753788)
Show SMILES COCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H28N2O6S2/c1-27-10-3-8-20(6-2-7-20)16(23)5-4-14-12-28-19(26)22(14)9-11-29-18-21-15(13-30-18)17(24)25/h4-5,13-14,16,23H,2-3,6-12H2,1H3,(H,24,25)/b5-4+/t14-,16+/m0/s1
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n/an/an/an/a 25n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50248168
PNG
(3-(4-(2,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)...)
Show SMILES Cn1cc(\C=C\C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc12
Show InChI InChI=1S/C24H16Cl2F2N2O4S/c1-30-13-14(5-10-23(31)29-35(32,33)16-7-8-18(27)19(28)12-16)24-20(30)3-2-4-22(24)34-21-9-6-15(25)11-17(21)26/h2-13H,1H3,(H,29,31)/b10-5+
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n/an/an/an/a 26.1n/an/an/an/a



deCODE Chemistry

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3-2 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 19: 1528-31 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.112
BindingDB Entry DOI: 10.7270/Q2JM29H0
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206012
PNG
(CHEMBL3956817)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@H](CCC(O)=O)CCC[C@H]12
Show InChI InChI=1S/C22H30O6/c23-15(14-27-16-5-2-1-3-6-16)9-11-18-19-8-4-7-17(10-12-22(25)26)28-21(19)13-20(18)24/h1-3,5-6,9,11,15,17-21,23-24H,4,7-8,10,12-14H2,(H,25,26)/b11-9+/t15-,17+,18-,19-,20-,21+/m1/s1
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n/an/an/an/a 27n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138055
PNG
(CHEMBL3753622)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCc2ccccc2)CCC1
Show InChI InChI=1S/C24H28N2O5S2/c27-20(24(10-4-11-24)12-9-17-5-2-1-3-6-17)8-7-18-15-31-23(30)26(18)13-14-32-22-25-19(16-33-22)21(28)29/h1-3,5-8,16,18,20,27H,4,9-15H2,(H,28,29)/b8-7+/t18-,20+/m0/s1
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n/an/an/an/a 27n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM62356
PNG
(US9422273, 12b)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C29H38ClF3N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/m0/s1
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n/an/an/an/a 47n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35854
PNG
(acrylic acid derivative, 12)
Show SMILES OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H22N2O3/c28-25(29)10-9-22-8-6-20(17-27-13-12-26-18-27)16-24(22)30-14-11-19-5-7-21-3-1-2-4-23(21)15-19/h1-10,12-13,15-16,18H,11,14,17H2,(H,28,29)/b10-9+
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16n/an/an/a 50n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138047
PNG
(CHEMBL3753853)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H28N2O5S2/c1-4-5-8-19(2,3)15(22)7-6-13-11-26-18(25)21(13)9-10-27-17-20-14(12-28-17)16(23)24/h6-7,12-13,15,22H,4-5,8-11H2,1-3H3,(H,23,24)/b7-6+/t13-,15+/m0/s1
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n/an/an/an/a 50n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238326
PNG
(US9394273, 15)
Show SMILES OC(Cc1ccc2ccsc2c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H26O4S/c27-22(15-18-3-5-20-13-14-31-25(20)16-18)10-8-19-9-12-24(28)23(19)11-4-17-1-6-21(7-2-17)26(29)30/h1-3,5-8,10,13-14,16,19,22-23,27H,4,9,11-12,15H2,(H,29,30)/b10-8+/t19-,22?,23+/m0/s1
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n/an/an/an/a 67n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35855
PNG
(acrylic acid derivative, 4)
Show SMILES OC(=O)\C=C\c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H22N2O3/c28-25(29)11-10-22-9-7-20(18-27-14-3-13-26-27)17-24(22)30-15-12-19-6-8-21-4-1-2-5-23(21)16-19/h1-11,13-14,16-17H,12,15,18H2,(H,28,29)/b11-10+
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12n/an/an/a 73n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240744
PNG
(US9422273, 12a)
Show SMILES Fc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
Show InChI InChI=1S/C29H38F4N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/m0/s1
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n/an/an/an/a 82n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240745
PNG
(US9422273, 12c)
Show SMILES COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
Show InChI InChI=1S/C30H41F3N4O6S/c1-42-24-14-12-22(13-15-27(38)36-44(40,41)30(31,32)33)23(18-24)19-37-17-7-11-26(37)29-35-25(20-43-29)28(39)34-16-6-5-10-21-8-3-2-4-9-21/h12,14,18,20-21,26H,2-11,13,15-17,19H2,1H3,(H,34,39)(H,36,38)/t26-/m0/s1
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n/an/an/an/a 100n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240747
PNG
(US9422273, 12e)
Show SMILES CCCCCCCCNC(=O)c1coc(n1)[C@@H]1CCCN1Cc1cc(F)ccc1CCC(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C27H36F4N4O5S/c1-2-3-4-5-6-7-14-32-25(37)22-18-40-26(33-22)23-9-8-15-35(23)17-20-16-21(28)12-10-19(20)11-13-24(36)34-41(38,39)27(29,30)31/h10,12,16,18,23H,2-9,11,13-15,17H2,1H3,(H,32,37)(H,34,36)/t23-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206023
PNG
(CHEMBL3976382)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2OC[C@H](CCCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C24H34O6/c25-18(16-29-19-7-2-1-3-8-19)11-13-20-21-12-10-17(6-4-5-9-24(27)28)15-30-23(21)14-22(20)26/h1-3,7-8,11,13,17-18,20-23,25-26H,4-6,9-10,12,14-16H2,(H,27,28)/b13-11+/t17-,18-,20-,21-,22-,23+/m1/s1
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n/an/an/an/a 130n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35859
PNG
(acrylic acid derivative, 16)
Show SMILES OC(=O)\C=C\c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C28H24O4/c29-28(30)15-14-24-13-11-22(20-32-26-8-2-1-3-9-26)19-27(24)31-17-16-21-10-12-23-6-4-5-7-25(23)18-21/h1-15,18-19H,16-17,20H2,(H,29,30)/b15-14+
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130n/an/an/a 140n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35858
PNG
(acrylic acid derivative, 15)
Show SMILES OC(=O)\C=C\c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H22O3S/c27-26(28)12-11-22-10-8-20(17-24-6-3-15-30-24)18-25(22)29-14-13-19-7-9-21-4-1-2-5-23(21)16-19/h1-12,15-16,18H,13-14,17H2,(H,27,28)/b12-11+
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150n/an/an/a 150n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240746
PNG
(US9422273, 12d)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1cc2OCOc2cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C30H39F3N4O7S/c31-30(32,33)45(40,41)36-27(38)12-11-21-15-25-26(44-19-43-25)16-22(21)17-37-14-6-10-24(37)29-35-23(18-42-29)28(39)34-13-5-4-9-20-7-2-1-3-8-20/h15-16,18,20,24H,1-14,17,19H2,(H,34,39)(H,36,38)/t24-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25BrO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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n/an/an/an/a 177n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25BrO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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n/an/an/an/a 180n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\CCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 260n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138101
PNG
(CHEMBL3754586)
Show SMILES CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H30N2O4S2/c1-3-4-5-14(2)12-16(23)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h6,8,13-16,23H,3-5,7,9-12H2,1-2H3,(H,25,26)/b8-6+/t14-,15-,16+/m0/s1
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n/an/an/an/a 310n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.039
BindingDB Entry DOI: 10.7270/Q2JS9S81
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35853
PNG
(acrylic acid derivative, 11)
Show SMILES OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1OCCc1cc2ccccc2o1
Show InChI InChI=1S/C23H20N2O4/c26-23(27)8-7-18-6-5-17(15-25-11-10-24-16-25)13-22(18)28-12-9-20-14-19-3-1-2-4-21(19)29-20/h1-8,10-11,13-14,16H,9,12,15H2,(H,26,27)/b8-7+
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44n/an/an/a 330n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\CCCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 360n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35857
PNG
(acrylic acid derivative, 14)
Show SMILES OC(=O)\C=C\c1ccc(Cc2ccccc2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C28H24O3/c29-28(30)15-14-25-13-11-23(18-21-6-2-1-3-7-21)20-27(25)31-17-16-22-10-12-24-8-4-5-9-26(24)19-22/h1-15,19-20H,16-18H2,(H,29,30)/b15-14+
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130n/an/an/a 400n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35864
PNG
(phenylbutanoic acid analogue, 20)
Show SMILES OC(=O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H26N2O3/c29-26(30)8-3-7-23-12-10-21(19-28-15-4-14-27-28)18-25(23)31-16-13-20-9-11-22-5-1-2-6-24(22)17-20/h1-2,4-6,9-12,14-15,17-18H,3,7-8,13,16,19H2,(H,29,30)
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39n/an/an/a 460n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35865
PNG
(benzyloxyacetic acid analogue, 21)
Show SMILES OC(=O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H24N2O4/c28-25(29)18-30-17-23-9-7-20(16-27-12-3-11-26-27)15-24(23)31-13-10-19-6-8-21-4-1-2-5-22(21)14-19/h1-9,11-12,14-15H,10,13,16-18H2,(H,28,29)
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210n/an/an/a 540n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206024
PNG
(CHEMBL3933326)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2OC[C@@H](CCCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C24H34O6/c25-18(16-29-19-7-2-1-3-8-19)11-13-20-21-12-10-17(6-4-5-9-24(27)28)15-30-23(21)14-22(20)26/h1-3,7-8,11,13,17-18,20-23,25-26H,4-6,9-10,12,14-16H2,(H,27,28)/b13-11+/t17-,18+,20+,21+,22+,23-/m0/s1
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n/an/an/an/a 540n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35856
PNG
(acrylic acid derivative, 13)
Show SMILES OC(=O)\C=C\c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H25NO4/c28-25-6-3-14-27(25)18-20-8-10-22(11-12-26(29)30)24(17-20)31-15-13-19-7-9-21-4-1-2-5-23(21)16-19/h1-2,4-5,7-12,16-17H,3,6,13-15,18H2,(H,29,30)/b12-11+
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110n/an/an/a 580n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35846
PNG
(acrylic acid derivative, 3)
Show SMILES Cc1c(C)c2OC(C)(CCOc3cc(Cn4ccnc4)ccc3\C=C\C(O)=O)CCc2c(C)c1O
Show InChI InChI=1S/C28H32N2O5/c1-18-19(2)27-23(20(3)26(18)33)9-10-28(4,35-27)11-14-34-24-15-21(16-30-13-12-29-17-30)5-6-22(24)7-8-25(31)32/h5-8,12-13,15,17,33H,9-11,14,16H2,1-4H3,(H,31,32)/b8-7+
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63n/an/an/a 600n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50206015
PNG
(CHEMBL3984438)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2OC[C@H](CCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C22H30O6/c23-16(14-27-17-4-2-1-3-5-17)8-10-18-19-9-6-15(7-11-22(25)26)13-28-21(19)12-20(18)24/h1-5,8,10,15-16,18-21,23-24H,6-7,9,11-14H2,(H,25,26)/b10-8+/t15-,16+,18+,19+,20+,21-/m0/s1
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n/an/an/an/a 870n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence...


ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238330
PNG
(US9394273, 19 | US9394273, 20)
Show SMILES OC(Cc1ccc(F)cc1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25FO4/c25-20-10-3-17(4-11-20)15-21(26)12-8-18-9-14-23(27)22(18)13-5-16-1-6-19(7-2-16)24(28)29/h1-4,6-8,10-12,18,21-22,26H,5,9,13-15H2,(H,28,29)/b12-8+/t18-,21?,22+/m0/s1
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US Patent
n/an/an/an/a 952n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostanoid EP3 Receptor


(Mus musculus (Mouse))
BDBM35862
PNG
(phenylpropynoic acid analogue, 18)
Show SMILES OC(=O)C#Cc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1
Show InChI InChI=1S/C25H20N2O3/c28-25(29)11-10-22-9-7-20(18-27-14-3-13-26-27)17-24(22)30-15-12-19-6-8-21-4-1-2-5-23(21)16-19/h1-9,13-14,16-17H,12,15,18H2,(H,28,29)
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99n/an/an/a 1.20E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd



Assay Description
Competitive binding studies were conducted using radiolabeled ligands and membrane fractions prepared from Chinese hamster ovary (CHO) cells stably e...


Bioorg Med Chem 17: 6567-82 (2009)


Article DOI: 10.1016/j.bmc.2009.08.007
BindingDB Entry DOI: 10.7270/Q23T9FK7
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1CCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
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