Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50101853![]() ((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
Minase Research Institute Curated by ChEMBL | Assay Description Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor | Bioorg Med Chem Lett 11: 2025-8 (2001) Article DOI: 10.1016/s0960-894x(01)00359-6 BindingDB Entry DOI: 10.7270/Q2CV4H1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM357272![]() (2-(((1s,4s)-4-((5-(2- hydroxyethylthio)-4-(3- meth...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Inc US Patent | Assay Description The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume... | US Patent US10214518 (2019) BindingDB Entry DOI: 10.7270/Q2T155XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM23954![]() (5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235368![]() (CHEMBL3893346) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235376![]() (CHEMBL3926078) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235374![]() (CHEMBL3935924) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103391![]() (CHEMBL3398233) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235379![]() (CHEMBL3932106 | US10668033, Compound 55) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | n/a | n/a | 5.14 | n/a | n/a | n/a | n/a |
ARENA PHARMACEUTICALS, INC. US Patent | Assay Description Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA... | US Patent US10668033 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235379![]() (CHEMBL3932106 | US10668033, Compound 55) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103396![]() (CHEMBL3398236) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235383![]() (ACT-293987 | NS-304 | SELEXIPAG | Selexipag | Uptr...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235375![]() (CHEMBL3975122) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM357269![]() (2-(((1s,4s)-4-((5- (ethylthio)-4-(2-fluoro-3- meth...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Inc US Patent | Assay Description The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume... | US Patent US10214518 (2019) BindingDB Entry DOI: 10.7270/Q2T155XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235389![]() (CHEMBL3983767) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235385![]() (APD-811 | RALINEPAG | Ralinepag) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103405![]() (CHEMBL3398215) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235370![]() (CHEMBL3933704) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103408![]() (CHEMBL3398220) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235378![]() (CHEMBL3981509) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103407![]() (CHEMBL3398219) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103394![]() (CHEMBL3398229) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM357271![]() (2-(((1s,4s)-4-((5- (cyanomethylthio)-3,4- diphenyl...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Inc US Patent | Assay Description The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume... | US Patent US10214518 (2019) BindingDB Entry DOI: 10.7270/Q2T155XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50169552![]() (CHEMBL3804978) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method | ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235373![]() (CHEMBL3928729) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM357270![]() (2-(((1s,4s)-4-((5- (methylthio)-4-(5- methylthioph...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Inc US Patent | Assay Description The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume... | US Patent US10214518 (2019) BindingDB Entry DOI: 10.7270/Q2T155XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM23963![]() ((2S)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 476 | n/a | 16 | n/a | n/a | 7.4 | 22 |
Pharmacopeia Drug Discovery Inc | Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R... | Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235391![]() (CHEMBL3914174) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235372![]() (CHEMBL3966307) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM444835![]() (2-(((1r,4r)-4-(((3- fluorophenyl)(5-methylthiophen...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 19.1 | n/a | n/a | n/a | n/a |
ARENA PHARMACEUTICALS, INC. US Patent | Assay Description Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA... | US Patent US10668033 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103392![]() (CHEMBL3398232) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103406![]() (CHEMBL3398218) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235367![]() (CHEMBL3952237) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235387![]() (CHEMBL239226) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235388![]() (CHEMBL3943791) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103431![]() (CHEMBL3398216) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50101829![]() (7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Minase Research Institute Curated by ChEMBL | Assay Description Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor | Bioorg Med Chem Lett 11: 2025-8 (2001) Article DOI: 10.1016/s0960-894x(01)00359-6 BindingDB Entry DOI: 10.7270/Q2CV4H1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235381![]() (CHEMBL3896580) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50206020![]() (CHEMBL3982726) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level by HTRF method | ACS Med Chem Lett 8: 107-112 (2017) Article DOI: 10.1021/acsmedchemlett.6b00415 BindingDB Entry DOI: 10.7270/Q2R78H6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103395![]() (CHEMBL3398235) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103403![]() (CHEMBL3398212) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50101824![]() (7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Minase Research Institute Curated by ChEMBL | Assay Description Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor | Bioorg Med Chem Lett 11: 2025-8 (2001) Article DOI: 10.1016/s0960-894x(01)00359-6 BindingDB Entry DOI: 10.7270/Q2CV4H1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235377![]() (CHEMBL3890685) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50103404![]() (CHEMBL3398228) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | Bioorg Med Chem Lett 25: 1030-5 (2015) Article DOI: 10.1016/j.bmcl.2015.01.024 BindingDB Entry DOI: 10.7270/Q2057HQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235390![]() (CHEMBL3952439) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235386![]() (CHEMBL3919269) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50169551![]() (CHEMBL3805134) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level by HTRF method | ACS Med Chem Lett 8: 107-112 (2017) Article DOI: 10.1021/acsmedchemlett.6b00415 BindingDB Entry DOI: 10.7270/Q2R78H6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50169551![]() (CHEMBL3805134) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method | ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM23960![]() (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g | 5-{[...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 53 | n/a | 51 | n/a | n/a | 7.4 | 22 |
Pharmacopeia Drug Discovery Inc | Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R... | Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50235384![]() (CHEMBL3900038) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 54 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by... | J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM444831![]() (2-(((1s,4s)-4-(((4- fluorophenyl)(phenyl) carbamoy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 56.9 | n/a | n/a | n/a | n/a |
ARENA PHARMACEUTICALS, INC. US Patent | Assay Description Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA... | US Patent US10668033 (2020) | |||||||||||
More data for this Ligand-Target Pair |
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