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Compile Data Set for Download or QSAR

Found 583 hits Enz. Inhib. hit(s) with Target = 'Prostanoid IP receptor'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50101853
PNG
((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 1.80n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor

Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103391
PNG
(CHEMBL3398233)
Show SMILES COc1ccc(cc1)-c1c(cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c1=O)-c1ccccc1
Show InChI InChI=1S/C30H28N2O5/c1-36-24-13-11-22(12-14-24)29-26(21-6-3-2-4-7-21)17-31-32(30(29)35)18-20-10-15-25-23(16-20)8-5-9-27(25)37-19-28(33)34/h2-9,11-14,17,20H,10,15-16,18-19H2,1H3,(H,33,34)
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n/an/an/an/a 4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103396
PNG
(CHEMBL3398236)
Show SMILES OC(=O)COc1cccc2C[C@H](Cn3ncc(-c4cccc(F)c4F)c(-c4ccc(F)cc4)c3=O)CCc12
Show InChI InChI=1S/C29H23F3N2O4/c30-20-10-8-18(9-11-20)27-23(22-4-2-5-24(31)28(22)32)14-33-34(29(27)37)15-17-7-12-21-19(13-17)3-1-6-25(21)38-16-26(35)36/h1-6,8-11,14,17H,7,12-13,15-16H2,(H,35,36)/t17-/m1/s1
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n/an/an/an/a 6n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103405
PNG
(CHEMBL3398215)
Show SMILES COc1ccc(cc1)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C30H28N2O5/c1-36-24-13-11-22(12-14-24)30-26(21-6-3-2-4-7-21)17-28(33)32(31-30)18-20-10-15-25-23(16-20)8-5-9-27(25)37-19-29(34)35/h2-9,11-14,17,20H,10,15-16,18-19H2,1H3,(H,34,35)
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n/an/an/an/a 8.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103408
PNG
(CHEMBL3398220)
Show SMILES COc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccc(C)cc1
Show InChI InChI=1S/C31H30N2O5/c1-20-9-12-22(13-10-20)31-27(24-5-3-7-25(16-24)37-2)17-29(34)33(32-31)18-21-11-14-26-23(15-21)6-4-8-28(26)38-19-30(35)36/h3-10,12-13,16-17,21H,11,14-15,18-19H2,1-2H3,(H,35,36)
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n/an/an/an/a 9.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103394
PNG
(CHEMBL3398229)
Show SMILES COc1cccc(c1F)-c1cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H27FN2O5/c1-37-26-12-6-10-23(29(26)31)24-16-32-33(30(36)28(24)20-7-3-2-4-8-20)17-19-13-14-22-21(15-19)9-5-11-25(22)38-18-27(34)35/h2-12,16,19H,13-15,17-18H2,1H3,(H,34,35)
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n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103407
PNG
(CHEMBL3398219)
Show SMILES COc1ccc(cc1F)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C30H27FN2O5/c1-37-27-13-11-22(15-25(27)31)30-24(20-6-3-2-4-7-20)16-28(34)33(32-30)17-19-10-12-23-21(14-19)8-5-9-26(23)38-18-29(35)36/h2-9,11,13,15-16,19H,10,12,14,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@H](CC[C@H]12)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 11n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23963
PNG
((2S)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@@H](Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C28H25N3O5/c1-18(32)30-23-9-5-8-22(16-23)21-12-10-20(11-13-21)15-25-26(29-17-36-25)27(33)31-24(28(34)35)14-19-6-3-2-4-7-19/h2-13,16-17,24H,14-15H2,1H3,(H,30,32)(H,31,33)(H,34,35)/t24-/m0/s1
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n/an/a 476n/a 16n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103392
PNG
(CHEMBL3398232)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4ccc(F)cc4)c3=O)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-23-12-10-21(11-13-23)28-25(20-5-2-1-3-6-20)16-31-32(29(28)35)17-19-9-14-24-22(15-19)7-4-8-26(24)36-18-27(33)34/h1-8,10-13,16,19H,9,14-15,17-18H2,(H,33,34)
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n/an/an/an/a 20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103406
PNG
(CHEMBL3398218)
Show SMILES COc1ccc(c(F)c1)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C30H27FN2O5/c1-37-22-11-13-24(26(31)15-22)30-25(20-6-3-2-4-7-20)16-28(34)33(32-30)17-19-10-12-23-21(14-19)8-5-9-27(23)38-18-29(35)36/h2-9,11,13,15-16,19H,10,12,14,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103431
PNG
(CHEMBL3398216)
Show SMILES Cc1ccc(cc1)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C30H28N2O4/c1-20-10-13-23(14-11-20)30-26(22-6-3-2-4-7-22)17-28(33)32(31-30)18-21-12-15-25-24(16-21)8-5-9-27(25)36-19-29(34)35/h2-11,13-14,17,21H,12,15-16,18-19H2,1H3,(H,34,35)
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n/an/an/an/a 24n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50101829
PNG
(7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...)
Show SMILES CCCC1(CCC1)[C@@H](O)C\C=C\C1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18?,20-,21+/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor

Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50206020
PNG
(CHEMBL3982726)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C22H30O6/c23-15(14-27-16-5-2-1-3-6-16)9-11-18-19-12-10-17(7-4-8-22(25)26)28-21(19)13-20(18)24/h1-3,5-6,9,11,15,17-21,23-24H,4,7-8,10,12-14H2,(H,25,26)/b11-9+/t15-,17-,18-,19-,20-,21+/m1/s1
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n/an/an/an/a 26n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level by HTRF method

ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103395
PNG
(CHEMBL3398235)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(F)c4F)c(-c4ccc(F)cc4)c3=O)CCc12
Show InChI InChI=1S/C29H23F3N2O4/c30-20-10-8-18(9-11-20)27-23(22-4-2-5-24(31)28(22)32)14-33-34(29(27)37)15-17-7-12-21-19(13-17)3-1-6-25(21)38-16-26(35)36/h1-6,8-11,14,17H,7,12-13,15-16H2,(H,35,36)
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n/an/an/an/a 33n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103403
PNG
(CHEMBL3398212)
Show SMILES COc1cccc(c1F)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C30H27FN2O5/c1-37-26-12-6-10-23(29(26)31)24-16-27(34)33(32-30(24)20-7-3-2-4-8-20)17-19-13-14-22-21(15-19)9-5-11-25(22)38-18-28(35)36/h2-12,16,19H,13-15,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 37n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50101824
PNG
(7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...)
Show SMILES CCCC1(CCC1)[C@@H](O)C\C=C\C1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC
Show InChI InChI=1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19?,21-,22+/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor

Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103404
PNG
(CHEMBL3398228)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(F)c4F)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1S/C29H24F2N2O4/c30-24-10-5-9-22(28(24)31)23-15-32-33(29(36)27(23)19-6-2-1-3-7-19)16-18-12-13-21-20(14-18)8-4-11-25(21)37-17-26(34)35/h1-11,15,18H,12-14,16-17H2,(H,34,35)
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n/an/an/an/a 38n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 47n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level by HTRF method

ACS Med Chem Lett 8: 107-112 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00415
BindingDB Entry DOI: 10.7270/Q2R78H6S
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@@H](CCCC(O)=O)CC[C@H]12
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 47n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23960
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g | 5-{[...)
Show SMILES C[C@@H](CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1
Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)/t19-/m0/s1
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n/an/a 53n/a 51n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103402
PNG
(CHEMBL3398211)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccccc4)c(cc3=O)-c3cccc(Cl)c3)CCc12
Show InChI InChI=1S/C29H25ClN2O4/c30-23-10-4-8-22(15-23)25-16-27(33)32(31-29(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-28(34)35/h1-11,15-16,19H,12-14,17-18H2,(H,34,35)
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n/an/an/an/a 60n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103412
PNG
(CHEMBL3398224)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(F)c4)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-23-10-4-8-22(15-23)25-16-31-32(29(35)28(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-27(33)34/h1-11,15-16,19H,12-14,17-18H2,(H,33,34)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103399
PNG
(CHEMBL3398208)
Show SMILES COc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C30H28N2O5/c1-36-24-11-5-9-23(16-24)26-17-28(33)32(31-30(26)21-7-3-2-4-8-21)18-20-13-14-25-22(15-20)10-6-12-27(25)37-19-29(34)35/h2-12,16-17,20H,13-15,18-19H2,1H3,(H,34,35)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103409
PNG
(CHEMBL3398221)
Show SMILES COc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C30H27FN2O5/c1-37-24-6-2-4-22(15-24)26-16-28(34)33(32-30(26)20-9-11-23(31)12-10-20)17-19-8-13-25-21(14-19)5-3-7-27(25)38-18-29(35)36/h2-7,9-12,15-16,19H,8,13-14,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 62n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23955
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b | N-be...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C26H23N3O3/c1-18(30)29-23-9-5-8-22(15-23)21-12-10-19(11-13-21)14-24-25(28-17-32-24)26(31)27-16-20-6-3-2-4-7-20/h2-13,15,17H,14,16H2,1H3,(H,27,31)(H,29,30)
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n/an/a 561n/a 66n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103397
PNG
(CHEMBL3398237)
Show SMILES OC(=O)COc1cccc2C(CCON=C(c3ccccc3)c3ccccc3)=CCCc12
Show InChI InChI=1S/C27H25NO4/c29-26(30)19-31-25-16-8-14-23-20(13-7-15-24(23)25)17-18-32-28-27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-6,8-14,16H,7,15,17-19H2,(H,29,30)
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n/an/an/an/a 79n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103390
PNG
(CHEMBL3398234)
Show SMILES COc1ccc(cc1F)-c1c(cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c1=O)-c1ccccc1
Show InChI InChI=1S/C30H27FN2O5/c1-37-27-13-11-22(15-25(27)31)29-24(20-6-3-2-4-7-20)16-32-33(30(29)36)17-19-10-12-23-21(14-19)8-5-9-26(23)38-18-28(34)35/h2-9,11,13,15-16,19H,10,12,14,17-18H2,1H3,(H,34,35)
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n/an/an/an/a 85n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103422
PNG
(CHEMBL3398225)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(Cl)c4)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1S/C29H25ClN2O4/c30-23-10-4-8-22(15-23)25-16-31-32(29(35)28(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-27(33)34/h1-11,15-16,19H,12-14,17-18H2,(H,33,34)
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n/an/an/an/a 86n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103410
PNG
(CHEMBL3398222)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1S/C29H26N2O4/c32-27(33)19-35-26-13-7-12-23-16-20(14-15-24(23)26)18-31-29(34)28(22-10-5-2-6-11-22)25(17-30-31)21-8-3-1-4-9-21/h1-13,17,20H,14-16,18-19H2,(H,32,33)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103423
PNG
(CHEMBL3398217)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccc(F)cc4)c(cc3=O)-c3ccccc3)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-23-12-10-21(11-13-23)29-25(20-5-2-1-3-6-20)16-27(33)32(31-29)17-19-9-14-24-22(15-19)7-4-8-26(24)36-18-28(34)35/h1-8,10-13,16,19H,9,14-15,17-18H2,(H,34,35)
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n/an/an/an/a 114n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103413
PNG
(CHEMBL3398227)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4F)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-25-11-5-4-10-23(25)24-16-31-32(29(35)28(24)20-7-2-1-3-8-20)17-19-13-14-22-21(15-19)9-6-12-26(22)36-18-27(33)34/h1-12,16,19H,13-15,17-18H2,(H,33,34)
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23956
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C27H25N3O3/c1-19(31)30-24-9-5-8-23(17-24)22-12-10-21(11-13-22)16-25-26(29-18-33-25)27(32)28-15-14-20-6-3-2-4-7-20/h2-13,17-18H,14-16H2,1H3,(H,28,32)(H,30,31)
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n/an/a 721n/a 138n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103416
PNG
(CHEMBL3398230)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4ccccc4F)c3=O)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-25-11-5-4-10-23(25)28-24(20-7-2-1-3-8-20)16-31-32(29(28)35)17-19-13-14-22-21(15-19)9-6-12-26(22)36-18-27(33)34/h1-12,16,19H,13-15,17-18H2,(H,33,34)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103411
PNG
(CHEMBL3398223)
Show SMILES COc1cccc(c1)-c1cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H28N2O5/c1-36-24-11-5-9-23(16-24)26-17-31-32(30(35)29(26)21-7-3-2-4-8-21)18-20-13-14-25-22(15-20)10-6-12-27(25)37-19-28(33)34/h2-12,16-17,20H,13-15,18-19H2,1H3,(H,33,34)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103400
PNG
(CHEMBL3398209)
Show SMILES Cc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C30H28N2O4/c1-20-7-5-10-23(15-20)26-17-28(33)32(31-30(26)22-8-3-2-4-9-22)18-21-13-14-25-24(16-21)11-6-12-27(25)36-19-29(34)35/h2-12,15,17,21H,13-14,16,18-19H2,1H3,(H,34,35)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50101822
PNG
((Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Show SMILES CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17-,19-/m1/s1
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n/an/an/an/a 260n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor

Bioorg Med Chem Lett 11: 2025-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00359-6
BindingDB Entry DOI: 10.7270/Q2CV4H1T
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103393
PNG
(CHEMBL3398231)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4cccc(F)c4)c3=O)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-23-10-4-9-22(15-23)28-25(20-6-2-1-3-7-20)16-31-32(29(28)35)17-19-12-13-24-21(14-19)8-5-11-26(24)36-18-27(33)34/h1-11,15-16,19H,12-14,17-18H2,(H,33,34)
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n/an/an/an/a 260n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23957
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d | 5-{[...)
Show SMILES CC(NC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-18(21-7-4-3-5-8-21)29-27(32)26-25(33-17-28-26)15-20-11-13-22(14-12-20)23-9-6-10-24(16-23)30-19(2)31/h3-14,16-18H,15H2,1-2H3,(H,29,32)(H,30,31)
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n/an/a 1.23E+3n/a 278n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM240747
PNG
(US9422273, 12e)
Show SMILES CCCCCCCCNC(=O)c1coc(n1)[C@@H]1CCCN1Cc1cc(F)ccc1CCC(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C27H36F4N4O5S/c1-2-3-4-5-6-7-14-32-25(37)22-18-40-26(33-22)23-9-8-15-35(23)17-20-16-21(28)12-10-19(20)11-13-24(36)34-41(38,39)27(29,30)31/h10,12,16,18,23H,2-9,11,13-15,17H2,1H3,(H,32,37)(H,34,36)/t23-/m0/s1
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n/an/an/an/a 290n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...

US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23961
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h | 5-{[...)
Show SMILES C[C@H](CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1
Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)/t19-/m1/s1
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n/an/a 916n/a 296n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 347n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23959
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1
Show InChI InChI=1S/C28H25N3O3/c1-18(32)30-23-9-5-8-22(15-23)20-12-10-19(11-13-20)14-26-27(29-17-34-26)28(33)31-25-16-24(25)21-6-3-2-4-7-21/h2-13,15,17,24-25H,14,16H2,1H3,(H,30,32)(H,31,33)/t24-,25+/m1/s1
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n/an/a 331n/a 358n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM50103401
PNG
(CHEMBL3398210)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccccc4)c(cc3=O)-c3cccc(F)c3)CCc12
Show InChI InChI=1S/C29H25FN2O4/c30-23-10-4-8-22(15-23)25-16-27(33)32(31-29(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-28(34)35/h1-11,15-16,19H,12-14,17-18H2,(H,34,35)
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n/an/an/an/a 380n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay

Bioorg Med Chem Lett 25: 1030-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.01.024
BindingDB Entry DOI: 10.7270/Q2057HQM
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23966
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccncc2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-4-2-3-22(16-23)21-7-5-20(6-8-21)15-24-25(29-17-33-24)26(32)28-14-11-19-9-12-27-13-10-19/h2-10,12-13,16-17H,11,14-15H2,1H3,(H,28,32)(H,30,31)
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n/an/a 4.71E+3n/a 476n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM240744
PNG
(US9422273, 12a)
Show SMILES Fc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
Show InChI InChI=1S/C29H38F4N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...

US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23965
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2cccnc2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-6-2-5-22(15-23)21-9-7-19(8-10-21)14-24-25(29-17-33-24)26(32)28-13-11-20-4-3-12-27-16-20/h2-10,12,15-17H,11,13-14H2,1H3,(H,28,32)(H,30,31)
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n/an/a 4.95E+3n/a 741n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23967
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C25H21N3O3/c1-17(29)27-22-9-5-6-20(15-22)19-12-10-18(11-13-19)14-23-24(26-16-31-23)25(30)28-21-7-3-2-4-8-21/h2-13,15-16H,14H2,1H3,(H,27,29)(H,28,30)
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n/an/a 3.48E+3n/a 828n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM23962
PNG
((2R)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@H](Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C28H25N3O5/c1-18(32)30-23-9-5-8-22(16-23)21-12-10-20(11-13-21)15-25-26(29-17-36-25)27(33)31-24(28(34)35)14-19-6-3-2-4-7-19/h2-13,16-17,24H,14-15H2,1H3,(H,30,32)(H,31,33)(H,34,35)/t24-/m1/s1
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n/an/a 4.20E+3n/a 831n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...

Bioorg Med Chem Lett 17: 1211-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.025
BindingDB Entry DOI: 10.7270/Q2RV0M0H
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))		BDBM62356
PNG
(US9422273, 12b)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C29H38ClF3N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/m0/s1
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n/an/an/an/a 860n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...

US Patent US9422273 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ076K
More data for this
Ligand-Target Pair
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