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Compile Data Set for Download or QSAR

Found 895 hits Enz. Inhib. hit(s) with Target = 'Protein Farnesyltransferase (PFT) Chain B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50143596
PNG
(30-oxo-(1R,5R)-19-oxa-2,6,10,12-tetraazahexacyclo[...)
Show SMILES O=C1C2CCN1[C@@H]1CCCc3ccc(Oc4cc(Cn5cncc5CN2)ccc4C#N)cc13
Show InChI InChI=1S/C26H25N5O2/c27-12-19-5-4-17-10-25(19)33-21-7-6-18-2-1-3-24(22(18)11-21)31-9-8-23(26(31)32)29-14-20-13-28-16-30(20)15-17/h4-7,10-11,13,16,23-24,29H,1-3,8-9,14-15H2/t23?,24-/m1/s1
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n/an/an/an/a 0.180n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit HDJ2 farnesylation in PSN-1 cells


J Med Chem 47: 1869-78 (2004)


Article DOI: 10.1021/jm0305467
BindingDB Entry DOI: 10.7270/Q2RX9CVX
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50143597
PNG
((S)-2-(2-[2-(4-Fluoro-phenyl)-ethyl]-5-{[(1S,4S)-4...)
Show SMILES CSCC[C@H](NC(=O)c1cc(NC[C@@H]2C[C@@H](CN2)SC(=O)c2cccnc2)ccc1CCc1ccc(F)cc1)C(=O)OC(C)C
Show InChI InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1
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1n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition binding constant against Farnesyltransferase


J Med Chem 47: 1869-78 (2004)


Article DOI: 10.1021/jm0305467
BindingDB Entry DOI: 10.7270/Q2RX9CVX
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088001
PNG
((+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-phenyl-(1...)
Show SMILES COc1ccccc1C(=C)C(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C31H29NO4/c1-20(22-12-7-9-15-26(22)36-2)28(33)32-18-27-30(21-10-4-3-5-11-21)17-16-25(31(27,19-32)29(34)35)23-13-6-8-14-24(23)30/h3-15,25,27H,1,16-19H2,2H3,(H,34,35)/t25-,27+,30-,31+/m1/s1
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25n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088009
PNG
((+/-)-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,...)
Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C30H29NO4/c1-35-25-14-8-5-9-20(25)17-27(32)31-18-26-29(21-10-3-2-4-11-21)16-15-24(30(26,19-31)28(33)34)22-12-6-7-13-23(22)29/h2-14,24,26H,15-19H2,1H3,(H,33,34)/t24-,26+,29-,30+/m1/s1
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140n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088004
PNG
(8-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-...)
Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@@](C1)(C(O)=O)[C@]1(O)CC[C@@]2(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C30H29NO5/c1-36-24-14-8-5-9-20(24)17-26(32)31-18-25-28(21-10-3-2-4-11-21)15-16-30(35,29(25,19-31)27(33)34)23-13-7-6-12-22(23)28/h2-14,25,35H,15-19H2,1H3,(H,33,34)/t25-,28+,29-,30-/m0/s1
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250n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088008
PNG
(11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,9S,...)
Show SMILES CONC(=O)[C@]12CN(C[C@H]1[C@]1(CC[C@@H]2c2ccccc12)c1ccccc1)C(=O)Cc1ccccc1OC
Show InChI InChI=1S/C31H32N2O4/c1-36-26-15-9-6-10-21(26)18-28(34)33-19-27-30(22-11-4-3-5-12-22)17-16-25(23-13-7-8-14-24(23)30)31(27,20-33)29(35)32-37-2/h3-15,25,27H,16-20H2,1-2H3,(H,32,35)/t25-,27+,30-,31+/m1/s1
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420n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088014
PNG
(1-(2,3-dihydrobenzo[b]furan-5-yl)-11-[2-(2-methoxy...)
Show SMILES COc1ccccc1C(=C)C(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccc3OCCc3c2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C33H31NO5/c1-20(23-7-4-6-10-28(23)38-2)30(35)34-18-29-32(22-11-12-27-21(17-22)14-16-39-27)15-13-26(33(29,19-34)31(36)37)24-8-3-5-9-25(24)32/h3-12,17,26,29H,1,13-16,18-19H2,2H3,(H,36,37)/t26-,29+,32-,33+/m1/s1
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420n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088013
PNG
(2-[11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,...)
Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2ccccc12)C(=O)NCC(O)=O
Show InChI InChI=1S/C32H32N2O5/c1-39-26-14-8-5-9-21(26)17-28(35)34-19-27-31(22-10-3-2-4-11-22)16-15-25(23-12-6-7-13-24(23)31)32(27,20-34)30(38)33-18-29(36)37/h2-14,25,27H,15-20H2,1H3,(H,33,38)(H,36,37)/t25-,27+,31-,32+/m1/s1
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738n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088002
PNG
(1-(4-carboxymethoxyphenyl)-11-[2-(2-methoxyphenyl)...)
Show SMILES COc1ccccc1C(=C)C(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccc(OCC(O)=O)cc2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C33H31NO7/c1-20(23-7-4-6-10-27(23)40-2)30(37)34-17-28-32(21-11-13-22(14-12-21)41-18-29(35)36)16-15-26(33(28,19-34)31(38)39)24-8-3-5-9-25(24)32/h3-14,26,28H,1,15-19H2,2H3,(H,35,36)(H,38,39)/t26-,28+,32-,33+/m1/s1
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2.55E+4n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088003
PNG
(11-[2-(2-benzyloxyphenyl)acetyl]-1-phenyl-(1R,8R,9...)
Show SMILES OC(=O)[C@]12CN(C[C@H]1[C@]1(CC[C@@H]2c2ccccc12)c1ccccc1)C(=O)Cc1ccccc1OCc1ccccc1
Show InChI InChI=1S/C36H33NO4/c38-33(21-26-13-7-10-18-31(26)41-23-25-11-3-1-4-12-25)37-22-32-35(27-14-5-2-6-15-27)20-19-30(36(32,24-37)34(39)40)28-16-8-9-17-29(28)35/h1-18,30,32H,19-24H2,(H,39,40)/t30-,32+,35-,36+/m1/s1
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3.20E+4n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088005
PNG
(2-(2-methoxyphenyl)-1-[1-phenyl-(1R,8S,9R,13R)-11-...)
Show SMILES COc1ccccc1CC(=O)N1C[C@H]2[C@@H](C1)[C@]1(CC[C@@H]2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C29H29NO2/c1-32-27-14-8-5-9-20(27)17-28(31)30-18-24-22-15-16-29(26(24)19-30,21-10-3-2-4-11-21)25-13-7-6-12-23(22)25/h2-14,22,24,26H,15-19H2,1H3/t22-,24-,26-,29-/m1/s1
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4.00E+4n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50088006
PNG
(6-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-...)
Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2cccc(O)c12)C(O)=O
Show InChI InChI=1S/C30H29NO5/c1-36-24-13-6-5-8-19(24)16-26(33)31-17-25-29(20-9-3-2-4-10-20)15-14-22(30(25,18-31)28(34)35)27-21(29)11-7-12-23(27)32/h2-13,22,25,32H,14-18H2,1H3,(H,34,35)/t22-,25+,29-,30+/m1/s1
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5.00E+4n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer S.A.

Curated by ChEMBL


Assay Description
Inhibition of farnesyltransferase by Ras/SPA assay


J Med Chem 43: 1807-16 (2000)


Article DOI: 10.1021/jm991166h
BindingDB Entry DOI: 10.7270/Q23N22MR
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50061465
PNG
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3cccnc3)c3ncccc3CCc2c1
Show InChI InChI=1S/C25H25ClN4O/c26-21-7-8-22-20(16-21)6-5-19-4-2-10-28-24(19)25(22)30-13-11-29(12-14-30)23(31)15-18-3-1-9-27-17-18/h1-4,7-10,16-17,25H,5-6,11-15H2
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n/an/a 6.22E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cells


J Med Chem 41: 877-93 (1998)


Article DOI: 10.1021/jm970462w
BindingDB Entry DOI: 10.7270/Q2M61JDN
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50061465
PNG
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3cccnc3)c3ncccc3CCc2c1
Show InChI InChI=1S/C25H25ClN4O/c26-21-7-8-22-20(16-21)6-5-19-4-2-10-28-24(19)25(22)30-13-11-29(12-14-30)23(31)15-18-3-1-9-27-17-18/h1-4,7-10,16-17,25H,5-6,11-15H2
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n/an/a 530n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene


J Med Chem 41: 877-93 (1998)


Article DOI: 10.1021/jm970462w
BindingDB Entry DOI: 10.7270/Q2M61JDN
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50063343
PNG
(1-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cycloh...)
Show SMILES CC(=O)N1CCCCC1C(=O)N1CCN(CC1)C1c2ccc(Cl)cc2CCc2cccnc12
Show InChI InChI=1S/C26H31ClN4O2/c1-18(32)31-12-3-2-6-23(31)26(33)30-15-13-29(14-16-30)25-22-10-9-21(27)17-20(22)8-7-19-5-4-11-28-24(19)25/h4-5,9-11,17,23,25H,2-3,6-8,12-16H2,1H3
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n/an/a 1.02E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene


J Med Chem 41: 877-93 (1998)


Article DOI: 10.1021/jm970462w
BindingDB Entry DOI: 10.7270/Q2M61JDN
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50061441
PNG
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CCc2c1
Show InChI InChI=1S/C25H25ClN4O/c26-21-5-6-22-20(17-21)4-3-19-2-1-9-28-24(19)25(22)30-14-12-29(13-15-30)23(31)16-18-7-10-27-11-8-18/h1-2,5-11,17,25H,3-4,12-16H2
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n/an/a 650n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human farnesyltransferase


J Med Chem 40: 4103-12 (1998)


Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50063343
PNG
(1-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cycloh...)
Show SMILES CC(=O)N1CCCCC1C(=O)N1CCN(CC1)C1c2ccc(Cl)cc2CCc2cccnc12
Show InChI InChI=1S/C26H31ClN4O2/c1-18(32)31-12-3-2-6-23(31)26(33)30-15-13-29(14-16-30)25-22-10-9-21(27)17-20(22)8-7-19-5-4-11-28-24(19)25/h4-5,9-11,17,23,25H,2-3,6-8,12-16H2,1H3
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n/an/a 1.02E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene


J Med Chem 41: 877-93 (1998)


Article DOI: 10.1021/jm970462w
BindingDB Entry DOI: 10.7270/Q2M61JDN
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048394
PNG
((S)-2-[((S)-2-{(S)-2-[(3H-Imidazol-4-ylmethyl)-ami...)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NCc1cnc[nH]1)C(C)C)C(O)=O
Show InChI InChI=1S/C24H33N5O4S/c1-15(2)21(26-12-18-11-25-14-27-18)23(31)29-13-17-7-5-4-6-16(17)10-20(29)22(30)28-19(24(32)33)8-9-34-3/h4-7,11,14-15,19-21,26H,8-10,12-13H2,1-3H3,(H,25,27)(H,28,30)(H,32,33)/t19-,20-,21-/m0/s1
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n/an/a 114n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048395
PNG
((S)-4-Carbamoyl-2-({(S)-2-[(S)-2-(2-3H-imidazol-4-...)
Show SMILES CC(C)(C)[C@H](NC(=O)Cc1cnc[nH]1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C26H34N6O6/c1-26(2,3)22(31-21(34)11-17-12-28-14-29-17)24(36)32-13-16-7-5-4-6-15(16)10-19(32)23(35)30-18(25(37)38)8-9-20(27)33/h4-7,12,14,18-19,22H,8-11,13H2,1-3H3,(H2,27,33)(H,28,29)(H,30,35)(H,31,34)(H,37,38)/t18-,19-,22+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048396
PNG
((S)-4-Carbamoyl-2-[((S)-2-{(S)-2-[2-(3H-imidazol-4...)
Show SMILES CC(C)(C)[C@H](NCCc1cnc[nH]1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C26H36N6O5/c1-26(2,3)22(29-11-10-18-13-28-15-30-18)24(35)32-14-17-7-5-4-6-16(17)12-20(32)23(34)31-19(25(36)37)8-9-21(27)33/h4-7,13,15,19-20,22,29H,8-12,14H2,1-3H3,(H2,27,33)(H,28,30)(H,31,34)(H,36,37)/t19-,20-,22+/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048963
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O4S2/c1-24(2,3)20(26-12-17(25)14-33)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-34-4/h5-8,17-20,26,33H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1
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n/an/a 0.570n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048967
PNG
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C[C@H](NC[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H38N4O3S2/c1-15(2)20(25-11-18(24)14-31)13-27-12-17-7-5-4-6-16(17)10-21(27)22(28)26-19(23(29)30)8-9-32-3/h4-7,15,18-21,25,31H,8-14,24H2,1-3H3,(H,26,28)(H,29,30)/t18-,19+,20-,21+/m0/s1
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n/an/a 0.75n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048968
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES COCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O5S/c1-24(2,3)20(26-12-17(25)14-34)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-33-4/h5-8,17-20,26,34H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048966
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CCCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O4S/c1-4-5-10-19(24(31)32)27-22(29)20-11-16-8-6-7-9-17(16)13-28(20)23(30)21(15(2)3)26-12-18(25)14-33/h6-9,15,18-21,26,33H,4-5,10-14,25H2,1-3H3,(H,27,29)(H,31,32)/t18-,19-,20+,21+/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048969
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CN(C)C(=O)CC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O
Show InChI InChI=1S/C26H41N5O5S/c1-26(2,3)22(28-13-18(27)15-37)24(34)31-14-17-9-7-6-8-16(17)12-20(31)23(33)29-19(25(35)36)10-11-21(32)30(4)5/h6-9,18-20,22,28,37H,10-15,27H2,1-5H3,(H,29,33)(H,35,36)/t18-,19-,20+,22-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048971
PNG
((R)-2-({(S)-1-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H]1CC=CCN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C19H34N4O4S2/c1-12(2)16(21-10-13(20)11-28)18(25)23-8-5-4-6-15(23)17(24)22-14(19(26)27)7-9-29-3/h4-5,12-16,21,28H,6-11,20H2,1-3H3,(H,22,24)(H,26,27)/t13-,14+,15-,16+/m0/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048965
PNG
((S)-2-{(R)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17+,18-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048972
PNG
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)20(25-11-17(24)13-32)22(29)27-12-16-7-5-4-6-15(16)10-19(27)21(28)26-18(23(30)31)8-9-33-3/h4-7,14,17-20,25,32H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18+,19+,20+/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048976
PNG
((S)-2-({2-[(S)-2-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)C1(Cc2ccccc2C1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H34N4O5S2/c1-13(2)18(26-19(28)16(24)12-33)20(29)27-23(10-14-6-4-5-7-15(14)11-23)22(32)25-17(21(30)31)8-9-34-3/h4-7,13,16-18,33H,8-12,24H2,1-3H3,(H,25,32)(H,26,28)(H,27,29)(H,30,31)/t16-,17-,18-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048974
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C24H37N5O5S/c1-24(2,3)20(27-11-16(25)13-35)22(32)29-12-15-7-5-4-6-14(15)10-18(29)21(31)28-17(23(33)34)8-9-19(26)30/h4-7,16-18,20,27,35H,8-13,25H2,1-3H3,(H2,26,30)(H,28,31)(H,33,34)/t16-,17-,18+,20-/m1/s1
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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048977
PNG
((R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2N1C(=O)[C@H](NC(=O)[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H32N4O5S2/c1-12(2)18(25-19(27)14(23)11-32)21(29)26-16-7-5-4-6-13(16)10-17(26)20(28)24-15(22(30)31)8-9-33-3/h4-7,12,14-15,17-18,32H,8-11,23H2,1-3H3,(H,24,28)(H,25,27)(H,30,31)/t14-,15-,17-,18-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048973
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](C)NC[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C21H32N4O4S2/c1-13(23-10-16(22)12-30)20(27)25-11-15-6-4-3-5-14(15)9-18(25)19(26)24-17(21(28)29)7-8-31-2/h3-6,13,16-18,23,30H,7-12,22H2,1-2H3,(H,24,26)(H,28,29)/t13-,16+,17+,18-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048979
PNG
((R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Show SMILES CSCC[C@@H](NC(=O)[C@H]1CC=CCN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C19H34N4O4S2/c1-12(2)16(21-10-13(20)11-28)18(25)23-8-5-4-6-15(23)17(24)22-14(19(26)27)7-9-29-3/h4-5,12-16,21,28H,6-11,20H2,1-3H3,(H,22,24)(H,26,27)/t13-,14+,15+,16+/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048980
PNG
((S)-2-{(E)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES CSCC[C@H](NC(=O)C(\NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)=C/c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H32N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,11,13,15-16,18,32H,9-10,12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/b17-11+/t15-,16-,18-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048981
PNG
((S)-2-({(R)-2-[(S)-2-((R)-3-Mercapto-2-methyl-prop...)
Show SMILES CSCC[C@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@@H](C)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H35N3O5S2/c1-14(2)20(26-21(28)15(3)13-33)23(30)27-12-17-8-6-5-7-16(17)11-19(27)22(29)25-18(24(31)32)9-10-34-4/h5-8,14-15,18-20,33H,9-13H2,1-4H3,(H,25,29)(H,26,28)(H,31,32)/t15-,18-,19+,20-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048975
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C23H35N5O5S/c1-13(2)20(26-10-16(24)12-34)22(31)28-11-15-6-4-3-5-14(15)9-18(28)21(30)27-17(23(32)33)7-8-19(25)29/h3-6,13,16-18,20,26,34H,7-12,24H2,1-2H3,(H2,25,29)(H,27,30)(H,32,33)/t16-,17-,18+,20+/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048982
PNG
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C[C@H](NC(=O)[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)19(26-21(28)17(24)13-32)12-27-11-16-7-5-4-6-15(16)10-20(27)22(29)25-18(23(30)31)8-9-33-3/h4-7,14,17-20,32H,8-13,24H2,1-3H3,(H,25,29)(H,26,28)(H,30,31)/t17-,18-,19+,20-/m1/s1
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n/an/a 0.370n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048983
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCSC)C(O)=O
Show InChI InChI=1S/C22H34N4O4S2/c1-3-17(24-11-16(23)13-31)21(28)26-12-15-7-5-4-6-14(15)10-19(26)20(27)25-18(22(29)30)8-9-32-2/h4-7,16-19,24,31H,3,8-13,23H2,1-2H3,(H,25,27)(H,29,30)/t16-,17+,18-,19+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048984
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CC(N)=O)C(O)=O
Show InChI InChI=1S/C22H33N5O5S/c1-12(2)19(25-9-15(23)11-33)21(30)27-10-14-6-4-3-5-13(14)7-17(27)20(29)26-16(22(31)32)8-18(24)28/h3-6,12,15-17,19,25,33H,7-11,23H2,1-2H3,(H2,24,28)(H,26,29)(H,31,32)/t15-,16-,17+,19+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048964
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(C)(=O)=O)C(O)=O
Show InChI InChI=1S/C23H36N4O6S2/c1-14(2)20(25-11-17(24)13-34)22(29)27-12-16-7-5-4-6-15(16)10-19(27)21(28)26-18(23(30)31)8-9-35(3,32)33/h4-7,14,17-20,25,34H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18-,19+,20+/m1/s1
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n/an/a 0.920n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048985
PNG
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Show SMILES CSCC[C@@H](NC[C@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)20(26-21(28)18(24)13-32)22(29)27-12-16-7-5-4-6-15(16)10-17(27)11-25-19(23(30)31)8-9-33-3/h4-7,14,17-20,25,32H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18-,19-,20-/m1/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048962
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES COC(=O)[C@@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C
Show InChI InChI=1S/C25H40N4O4S2/c1-25(2,3)21(27-13-18(26)15-34)23(31)29-14-17-9-7-6-8-16(17)12-20(29)22(30)28-19(10-11-35-5)24(32)33-4/h6-9,18-21,27,34H,10-15,26H2,1-5H3,(H,28,30)/t18-,19-,20+,21-/m1/s1
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n/an/a 85n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048970
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(C)(=O)=O)C(O)=O
Show InChI InChI=1S/C24H38N4O6S2/c1-24(2,3)20(26-12-17(25)14-35)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-36(4,33)34/h5-8,17-20,26,35H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1
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n/an/a 0.460n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048978
PNG
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(N)(=O)=O)C(O)=O
Show InChI InChI=1S/C22H35N5O6S2/c1-13(2)19(25-10-16(23)12-34)21(29)27-11-15-6-4-3-5-14(15)9-18(27)20(28)26-17(22(30)31)7-8-35(24,32)33/h3-6,13,16-19,25,34H,7-12,23H2,1-2H3,(H,26,28)(H,30,31)(H2,24,32,33)/t16-,17-,18+,19+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048986
PNG
((R)-2-({3-[(S)-2-((R)-2-Amino-3-mercapto-propylami...)
Show SMILES CSCC[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H34N4O4S2/c1-14(2)21(26-12-17(25)13-33)23(30)28-20-11-16-7-5-4-6-15(16)10-18(20)22(29)27-19(24(31)32)8-9-34-3/h4-7,10-11,14,17,19,21,26,33H,8-9,12-13,25H2,1-3H3,(H,27,29)(H,28,30)(H,31,32)/t17-,19-,21+/m1/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase


J Med Chem 39: 224-36 (1996)


Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048397
PNG
((S)-2-((S)-2-{(S)-2-[(S)-2-Amino-3-(3H-imidazol-4-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)C(O)=O
Show InChI InChI=1S/C25H36N6O5S/c1-15(2)21(31-22(32)18(26)12-17-13-27-14-28-17)24(34)30-20(11-16-7-5-4-6-8-16)23(33)29-19(25(35)36)9-10-37-3/h4-8,13-15,18-21H,9-12,26H2,1-3H3,(H,27,28)(H,29,33)(H,30,34)(H,31,32)(H,35,36)/t18-,19-,20-,21-/m0/s1
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n/an/a 6.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048398
PNG
((S)-4-Carbamoyl-2-[((S)-2-{(S)-2-[3-(3H-imidazol-4...)
Show SMILES CC(C)(C)[C@H](NCCCc1cnc[nH]1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C27H38N6O5/c1-27(2,3)23(30-12-6-9-19-14-29-16-31-19)25(36)33-15-18-8-5-4-7-17(18)13-21(33)24(35)32-20(26(37)38)10-11-22(28)34/h4-5,7-8,14,16,20-21,23,30H,6,9-13,15H2,1-3H3,(H2,28,34)(H,29,31)(H,32,35)(H,37,38)/t20-,21-,23+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048399
PNG
((S)-2-[((S)-2-{(S)-2-[2-(3H-Imidazol-4-yl)-ethylam...)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NCCc1cnc[nH]1)C(C)C)C(O)=O
Show InChI InChI=1S/C25H35N5O4S/c1-16(2)22(27-10-8-19-13-26-15-28-19)24(32)30-14-18-7-5-4-6-17(18)12-21(30)23(31)29-20(25(33)34)9-11-35-3/h4-7,13,15-16,20-22,27H,8-12,14H2,1-3H3,(H,26,28)(H,29,31)(H,33,34)/t20-,21-,22-/m0/s1
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n/an/a 0.790n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048402
PNG
((S)-2-({(S)-2-[(S)-2-(2-3H-Imidazol-4-yl-acetylami...)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)Cc1cnc[nH]1)C(C)C)C(O)=O
Show InChI InChI=1S/C25H33N5O5S/c1-15(2)22(29-21(31)11-18-12-26-14-27-18)24(33)30-13-17-7-5-4-6-16(17)10-20(30)23(32)28-19(25(34)35)8-9-36-3/h4-7,12,14-15,19-20,22H,8-11,13H2,1-3H3,(H,26,27)(H,28,32)(H,29,31)(H,34,35)/t19-,20-,22-/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50048400
PNG
((S)-2-[((S)-2-{(S)-2-[(3H-Imidazole-4-carbonyl)-am...)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)c1cnc[nH]1)C(C)C)C(O)=O
Show InChI InChI=1S/C24H31N5O5S/c1-14(2)20(28-21(30)18-11-25-13-26-18)23(32)29-12-16-7-5-4-6-15(16)10-19(29)22(31)27-17(24(33)34)8-9-35-3/h4-7,11,13-14,17,19-20H,8-10,12H2,1-3H3,(H,25,26)(H,27,31)(H,28,30)(H,33,34)/t17-,19-,20-/m0/s1
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n/an/a 84n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Farnesyltransferase


J Med Chem 39: 353-8 (1996)


Article DOI: 10.1021/jm9507284
BindingDB Entry DOI: 10.7270/Q2QZ2925
More data for this
Ligand-Target Pair
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