BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 259 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126036
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-3-35-26-6-4-5-24(16-26)27-15-22(18-31)7-10-23(27)13-14-29(34,28-19-32-20-33(28)2)25-11-8-21(17-30)9-12-25/h4-12,15-16,19-20,34H,3H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126320
PNG
(1-{[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-m...)
Show SMILES Cn1cncc1C(NN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H24N6/c1-33-19-31-17-27(33)28(22-11-9-20(15-29)10-12-22)32-34-14-13-23(16-30)26(18-34)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28,32H,13-14,18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of geranylgeranyltransferase-1


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50135353
PNG
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H20ClN5O2/c1-31-16-30-14-23(31)25(18-8-6-17(12-28)7-9-18)34-15-24-22(19-4-3-5-21(27)10-19)11-20(13-29)26(33)32(24)2/h3-11,14,16,25H,15H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Factor Xa


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126322
PNG
(4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...)
Show SMILES Cn1cncc1CN(Cc1ccc(C#N)c(Br)c1)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12
Show InChI InChI=1S/C30H25BrN6O/c1-35-20-34-16-25(35)18-37(17-21-9-10-24(15-33)29(31)13-21)30(38)36-12-11-23(14-32)28(19-36)27-8-4-6-22-5-2-3-7-26(22)27/h2-10,13,16,20H,11-12,17-19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of geranylgeranyltransferase-1


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153785
PNG
(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)
Show SMILES N#Cc1ccc(Cn2cncc2COc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1
Show InChI InChI=1S/C29H20N4O/c30-15-21-8-10-22(11-9-21)18-33-20-32-17-25(33)19-34-26-13-12-24(16-31)29(14-26)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.20n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153168
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CNCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H25N5O/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)16-31-17-26-18-32-20-33(26)19-22-8-6-21(14-29)7-9-22/h3-13,18,20,31H,2,16-17,19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.34n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153170
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(C)Cc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H27N5O/c1-3-35-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-33(2)20-27-17-32-21-34(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.57n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126335
PNG
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153797
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O/c28-27(29,30)24-9-7-22(8-10-24)26-11-21(13-32)5-6-23(26)16-35-17-25-14-33-18-34(25)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126335
PNG
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells


Bioorg Med Chem Lett 14: 5367-70 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.012
BindingDB Entry DOI: 10.7270/Q2NS0TC9
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153169
PNG
(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)cc1
Show InChI InChI=1S/C27H20N4O3/c28-11-19-1-3-20(4-2-19)14-31-17-30-13-24(31)16-32-15-23-6-5-21(12-29)9-25(23)22-7-8-26-27(10-22)34-18-33-26/h1-10,13,17H,14-16,18H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.65n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126041
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.74n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126317
PNG
(1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}...)
Show SMILES O=C(Cc1cncn1Cc1ccc(cc1)C#N)N1CCC(C#N)=C(C1)c1cccc2ccccc12
Show InChI InChI=1S/C29H23N5O/c30-15-21-8-10-22(11-9-21)18-34-20-32-17-25(34)14-29(35)33-13-12-24(16-31)28(19-33)27-7-3-5-23-4-1-2-6-26(23)27/h1-11,17,20H,12-14,18-19H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/an/an/a 3.90n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of geranylgeranyltransferase-1


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM16181
PNG
(1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imid...)
Show SMILES Cn1cncc1C(O)(CN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H25N5O/c1-33-20-32-17-28(33)29(35,24-11-9-21(15-30)10-12-24)19-34-14-13-23(16-31)27(18-34)26-8-4-6-22-5-2-3-7-25(22)26/h2-12,17,20,35H,13-14,18-19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM13382
PNG
(3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H19ClN4O/c1-31-17-30-15-25(31)26(20-8-5-18(13-28)6-9-20)32-16-22-10-7-19(14-29)11-24(22)21-3-2-4-23(27)12-21/h2-12,15,17,26H,16H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5.20n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153166
PNG
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.70n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153166
PNG
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.70n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50151520
PNG
(3-{4-(3-chlorophenyl)-5-[4-cyanophenyl(1-methyl-1H...)
Show SMILES Cn1cncc1C(OCc1cn(Cc2cccc(c2)C#N)c(=O)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C32H24ClN5O2/c1-37-21-36-17-30(37)32(25-10-8-22(15-34)9-11-25)40-20-27-19-38(18-24-5-2-4-23(12-24)16-35)31(39)14-29(27)26-6-3-7-28(33)13-26/h2-14,17,19,21,32H,18,20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Factor Xa


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50151519
PNG
(4-[[1-(3-Chloro-benzyl)-4-(3-chloro-phenyl)-6-oxo-...)
Show SMILES Cn1cncc1C(OCc1cn(Cc2cccc(Cl)c2)c(=O)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C31H24Cl2N4O2/c1-36-20-35-16-29(36)31(23-10-8-21(15-34)9-11-23)39-19-25-18-37(17-22-4-2-6-26(32)12-22)30(38)14-28(25)24-5-3-7-27(33)13-24/h2-14,16,18,20,31H,17,19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Factor Xa


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50151521
PNG
(4-(3-Chloro-phenyl)-5-[(4-cyano-phenyl)-(3-methyl-...)
Show SMILES Cn1cncc1C(OCc1c(cc(C#N)n(C)c1=O)-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H20ClN5O2/c1-31-16-30-14-24(31)25(18-8-6-17(12-28)7-9-18)34-15-23-22(19-4-3-5-20(27)10-19)11-21(13-29)32(2)26(23)33/h3-11,14,16,25H,15H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Factor Xa


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157246
PNG
(6''-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(...)
Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCC(CO)CC1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C32H29F3N6O2/c1-40-20-38-17-29(40)30(22-6-7-23(15-36)27(14-22)26-4-2-3-5-28(26)32(33,34)35)43-19-25-9-8-24(16-37)31(39-25)41-12-10-21(18-42)11-13-41/h2-9,14,17,20-21,30,42H,10-13,18-19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157270
PNG
(6''-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(...)
Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCCC(O)C1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C31H27F3N6O2/c1-39-19-37-16-28(39)29(42-18-23-11-10-22(15-36)30(38-23)40-12-4-5-24(41)17-40)20-8-9-21(14-35)26(13-20)25-6-2-3-7-27(25)31(32,33)34/h2-3,6-11,13,16,19,24,29,41H,4-5,12,17-18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50151515
PNG
(4-[[4-(3-Chloro-phenyl)-1-(3-fluoro-benzyl)-6-oxo-...)
Show SMILES Cn1cncc1C(OCc1cn(Cc2cccc(F)c2)c(=O)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C31H24ClFN4O2/c1-36-20-35-16-29(36)31(23-10-8-21(15-34)9-11-23)39-19-25-18-37(17-22-4-2-7-27(33)12-22)30(38)14-28(25)24-5-3-6-26(32)13-24/h2-14,16,18,20,31H,17,19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Factor Xa


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50151516
PNG
(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(OCc1c(cc(C#N)n(C)c1=O)-c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H19Cl2N5O2/c1-32-15-31-13-24(32)25(17-5-3-16(11-29)4-6-17)35-14-23-22(10-21(12-30)33(2)26(23)34)18-7-19(27)9-20(28)8-18/h3-10,13,15,25H,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of compound towards Factor Xa


Bioorg Med Chem Lett 14: 4603-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.004
BindingDB Entry DOI: 10.7270/Q27080WG
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153164
PNG
(CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)C(C)=O)C#N
Show InChI InChI=1S/C30H27N5O2/c1-3-37-29-6-4-5-26(14-29)30-13-25(16-32)11-12-27(30)19-34(22(2)36)20-28-17-33-21-35(28)18-24-9-7-23(15-31)8-10-24/h4-14,17,21H,3,18-20H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153783
PNG
(5-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...)
Show SMILES N#Cc1ccc(COCc2cncn2Cc2ccc(nc2)C#N)c(c1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C26H19N5O3/c27-9-18-1-3-21(24(7-18)20-4-6-25-26(8-20)34-17-33-25)14-32-15-23-12-29-16-31(23)13-19-2-5-22(10-28)30-11-19/h1-8,11-12,16H,13-15,17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM17325
PNG
((2S)-2-[(4-{[butyl(2-cyclohexylethyl)amino]methyl}...)
Show SMILES CCCCN(CCC1CCCCC1)Cc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C
Show InChI InChI=1S/C32H46N2O3S/c1-4-5-19-34(20-17-25-12-7-6-8-13-25)23-26-15-16-28(29(22-26)27-14-10-9-11-24(27)2)31(35)33-30(32(36)37)18-21-38-3/h9-11,14-16,22,25,30H,4-8,12-13,17-21,23H2,1-3H3,(H,33,35)(H,36,37)/t30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153171
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-2-35-26-5-3-4-25(15-26)27-14-23(17-31)10-11-24(27)12-13-29(34)28-18-32-20-33(28)19-22-8-6-21(16-30)7-9-22/h3-11,14-15,18,20,29,34H,2,19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 16.7n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153776
PNG
(5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N
Show InChI InChI=1S/C27H23N5O2/c1-2-34-26-5-3-4-22(11-26)27-10-20(12-28)6-8-23(27)17-33-18-25-15-30-19-32(25)16-21-7-9-24(13-29)31-14-21/h3-11,14-15,19H,2,16-18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 17n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153769
PNG
(5-(3-Chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imi...)
Show SMILES Cn1c(CNCc2cncn2Cc2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H21ClN6O/c1-32-25(24(10-21(12-29)26(32)34)20-3-2-4-22(27)9-20)15-30-13-23-14-31-17-33(23)16-19-7-5-18(11-28)6-8-19/h2-10,14,17,30H,13,15-16H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells at 100 nM


Bioorg Med Chem Lett 14: 5367-70 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.012
BindingDB Entry DOI: 10.7270/Q2NS0TC9
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153173
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)18-33-19-26-16-31-20-32(26)17-22-8-6-21(14-29)7-9-22/h3-13,16,20H,2,17-19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 21.9n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126323
PNG
(1-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-propion...)
Show SMILES O=C(CCc1cncn1Cc1ccc(cc1)C#N)N1CCC(C#N)=C(C1)c1cccc2ccccc12
Show InChI InChI=1S/C30H25N5O/c31-16-22-8-10-23(11-9-22)19-35-21-33-18-26(35)12-13-30(36)34-15-14-25(17-32)29(20-34)28-7-3-5-24-4-1-2-6-27(24)28/h1-11,18,21H,12-15,19-20H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 28n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153791
PNG
(6-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...)
Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)nc1
Show InChI InChI=1S/C26H19N5O3/c27-9-18-1-3-21(24(7-18)20-4-6-25-26(8-20)34-17-33-25)14-32-15-23-12-29-16-31(23)13-22-5-2-19(10-28)11-30-22/h1-8,11-12,16H,13-15,17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 29n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157277
PNG
(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCN(CCO)CC1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C32H30F3N7O2/c1-40-21-38-19-29(40)30(22-6-7-23(17-36)27(16-22)26-4-2-3-5-28(26)32(33,34)35)44-20-25-9-8-24(18-37)31(39-25)42-12-10-41(11-13-42)14-15-43/h2-9,16,19,21,30,43H,10-15,20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126326
PNG
(1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Show SMILES Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H23N5/c1-32-19-31-17-27(32)28(22-11-9-20(15-29)10-12-22)33-14-13-23(16-30)26(18-33)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28H,13-14,18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 31n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153175
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H22N4O2/c1-32-26-4-2-3-23(12-26)27-11-22(14-29)9-10-24(27)17-33-18-25-15-30-19-31(25)16-21-7-5-20(13-28)6-8-21/h2-12,15,19H,16-18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 32n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153796
PNG
(6-(((1-(4-chlorobenzyl)-1H-imidazol-5-yl)methoxy)m...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(Cl)cc1)C#N
Show InChI InChI=1S/C27H24ClN3O2/c1-2-33-26-5-3-4-22(13-26)27-12-21(14-29)6-9-23(27)17-32-18-25-15-30-19-31(25)16-20-7-10-24(28)11-8-20/h3-13,15,19H,2,16-18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 34n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153174
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 52n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153174
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 52n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157238
PNG
(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Show SMILES CN1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(C#N)c(c2)-c2ccccc2C(F)(F)F)ccc1C#N
Show InChI InChI=1S/C31H28F3N7O/c1-39-11-13-41(14-12-39)30-23(17-36)9-10-24(38-30)19-42-29(28-18-37-20-40(28)2)21-7-8-22(16-35)26(15-21)25-5-3-4-6-27(25)31(32,33)34/h3-10,15,18,20,29H,11-14,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 53n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153167
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-34-25-4-2-3-24(14-25)26-13-22(16-30)9-10-23(26)11-12-28(33)27-17-31-19-32(27)18-21-7-5-20(15-29)6-8-21/h2-10,13-14,17,19,28,33H,18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 57.5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153778
PNG
(6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...)
Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)nc1
Show InChI InChI=1S/C28H19N5O/c29-13-21-9-11-28(32-15-21)34-18-24-16-31-19-33(24)17-20-8-10-23(14-30)27(12-20)26-7-3-5-22-4-1-2-6-25(22)26/h1-12,15-16,19H,17-18H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 60n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153792
PNG
(4''-Acetyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Show SMILES CC(=O)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H22N4O2/c1-20(33)24-8-10-25(11-9-24)28-12-23(14-30)6-7-26(28)17-34-18-27-15-31-19-32(27)16-22-4-2-21(13-29)3-5-22/h2-12,15,19H,16-18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 77n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of H-Ras transformed NIH-3T3-cell proliferation


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157254
PNG
(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H19F3N4O/c1-34-17-33-15-25(34)26(35-16-19-8-6-18(13-31)7-9-19)20-10-11-21(14-32)23(12-20)22-4-2-3-5-24(22)27(28,29)30/h2-12,15,17,26H,16H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 85n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157256
PNG
(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCOCC1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H25F3N6O2/c1-38-19-36-17-27(38)28(41-18-23-9-8-22(16-35)29(37-23)39-10-12-40-13-11-39)20-6-7-21(15-34)25(14-20)24-4-2-3-5-26(24)30(31,32)33/h2-9,14,17,19,28H,10-13,18H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 89n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157240
PNG
(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Show SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H18F3N5O/c1-34-16-32-14-24(34)25(35-15-20-9-6-17(11-30)13-33-20)18-7-8-19(12-31)22(10-18)21-4-2-3-5-23(21)26(27,28)29/h2-10,13-14,16,25H,15H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 90n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126325
PNG
(4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...)
Show SMILES Cn1cncc1CN(Cc1ccc(cc1)C#N)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12
Show InChI InChI=1S/C30H26N6O/c1-34-21-33-17-26(34)19-36(18-23-11-9-22(15-31)10-12-23)30(37)35-14-13-25(16-32)29(20-35)28-8-4-6-24-5-2-3-7-27(24)28/h2-12,17,21H,13-14,18-20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 97n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of geranylgeranyltransferase-1


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126318
PNG
(1-{2-[3-(4-Chloro-benzyl)-3H-imidazol-4-yl]-acetyl...)
Show SMILES Clc1ccc(Cn2cncc2CC(=O)N2CCC(C#N)=C(C2)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C28H23ClN4O/c29-23-10-8-20(9-11-23)17-33-19-31-16-24(33)14-28(34)32-13-12-22(15-30)27(18-32)26-7-3-5-21-4-1-2-6-25(21)26/h1-11,16,19H,12-14,17-18H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126324
PNG
(1-{2-[3-(4-Cyano-3-naphthalen-1-yl-benzyl)-3H-imid...)
Show SMILES COC1=C(CCN(C1)C(=O)Cc1cncn1Cc1ccc(C#N)c(c1)-c1cccc2ccccc12)C#N
Show InChI InChI=1S/C30H25N5O2/c1-37-29-19-34(12-11-24(29)16-32)30(36)14-25-17-33-20-35(25)18-21-9-10-23(15-31)28(13-21)27-8-4-6-22-5-2-3-7-26(22)27/h2-10,13,17,20H,11-12,14,18-19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of geranylgeranyltransferase-1


Bioorg Med Chem Lett 13: 1363-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00094-5
BindingDB Entry DOI: 10.7270/Q24B30PD
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50157253
PNG
(5-[(4-Fluoro-3-trifluoromethyl-benzyloxy)-(3-methy...)
Show SMILES Cn1cncc1C(OCc1ccc(F)c(c1)C(F)(F)F)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H18F7N3O/c1-37-15-36-13-24(37)25(38-14-16-6-9-23(28)22(10-16)27(32,33)34)17-7-8-18(12-35)20(11-17)19-4-2-3-5-21(19)26(29,30)31/h2-11,13,15,25H,14H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against H-ras processing in transformed NIH3T3 cells


Bioorg Med Chem Lett 15: 153-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.014
BindingDB Entry DOI: 10.7270/Q2TT4QFC
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 259 total )  |  Next  |  Last  >>
Jump to: