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Compile Data Set for Download or QSAR

Found 903 hits Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 4 (PAR4)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PAR4


(Homo sapiens (Human))
BDBM176195
PNG
(US10047103, 228 | US9688695, 228)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(F)nc2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C25H18FN5O3S/c1-14-3-6-24-29-19(11-31(24)30-14)22-9-18-20(7-17(32-2)8-21(18)34-22)33-12-16-13-35-25(28-16)15-4-5-23(26)27-10-15/h3-11,13H,12H2,1-2H3
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n/an/an/an/a 0.180n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176195
PNG
(US10047103, 228 | US9688695, 228)
Show SMILES COc1cc(OCc2csc(n2)-c2ccc(F)nc2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C25H18FN5O3S/c1-14-3-6-24-29-19(11-31(24)30-14)22-9-18-20(7-17(32-2)8-21(18)34-22)33-12-16-13-35-25(28-16)15-4-5-23(26)27-10-15/h3-11,13H,12H2,1-2H3
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n/an/an/an/a 0.180n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176017
PNG
(US10047103, 50 | US9688695, 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(CC(C)C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C22H22N4O4S2/c1-12(2)5-20-23-13(11-31-20)10-29-17-6-14(27-3)7-18-15(17)8-19(30-18)16-9-26-21(24-16)32-22(25-26)28-4/h6-9,11-12H,5,10H2,1-4H3
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n/an/an/an/a 0.210n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176017
PNG
(US10047103, 50 | US9688695, 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(CC(C)C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C22H22N4O4S2/c1-12(2)5-20-23-13(11-31-20)10-29-17-6-14(27-3)7-18-15(17)8-19(30-18)16-9-26-21(24-16)32-22(25-26)28-4/h6-9,11-12H,5,10H2,1-4H3
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n/an/an/an/a 0.210n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176036
PNG
(US10047103, 69 | US9688695, 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(CO)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N4O5S2/c1-31-17-7-20(33-12-16-13-35-23(26-16)15-5-3-14(11-30)4-6-15)18-9-22(34-21(18)8-17)19-10-29-24(27-19)36-25(28-29)32-2/h3-10,13,30H,11-12H2,1-2H3
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n/an/an/an/a 0.230n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176036
PNG
(US10047103, 69 | US9688695, 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(CO)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N4O5S2/c1-31-17-7-20(33-12-16-13-35-23(26-16)15-5-3-14(11-30)4-6-15)18-9-22(34-21(18)8-17)19-10-29-24(27-19)36-25(28-29)32-2/h3-10,13,30H,11-12H2,1-2H3
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n/an/an/an/a 0.230n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176023
PNG
(US10047103, 56 | US9688695, 56)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C23H23N5O5S2/c1-29-15-8-18(32-12-14-13-34-21(24-14)27-4-3-6-31-7-5-27)16-10-20(33-19(16)9-15)17-11-28-22(25-17)35-23(26-28)30-2/h8-11,13H,3-7,12H2,1-2H3
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n/an/an/an/a 0.240n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176023
PNG
(US10047103, 56 | US9688695, 56)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C23H23N5O5S2/c1-29-15-8-18(32-12-14-13-34-21(24-14)27-4-3-6-31-7-5-27)16-10-20(33-19(16)9-15)17-11-28-22(25-17)35-23(26-28)30-2/h8-11,13H,3-7,12H2,1-2H3
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n/an/an/an/a 0.240n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176067
PNG
(US10047103, 100 | US9688695, 100)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCN(CC3)S(C)(=O)=O)cc(OC)cc2o1
Show InChI InChI=1S/C23H24N6O6S3/c1-32-15-8-18(34-12-14-13-36-21(24-14)27-4-6-28(7-5-27)38(3,30)31)16-10-20(35-19(16)9-15)17-11-29-22(25-17)37-23(26-29)33-2/h8-11,13H,4-7,12H2,1-3H3
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n/an/an/an/a 0.25n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176067
PNG
(US10047103, 100 | US9688695, 100)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCN(CC3)S(C)(=O)=O)cc(OC)cc2o1
Show InChI InChI=1S/C23H24N6O6S3/c1-32-15-8-18(34-12-14-13-36-21(24-14)27-4-6-28(7-5-27)38(3,30)31)16-10-20(35-19(16)9-15)17-11-29-22(25-17)37-23(26-29)33-2/h8-11,13H,4-7,12H2,1-3H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176007
PNG
(US10047103, 40 | US9688695, 40)
Show SMILES CNC(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C26H21N5O5S2/c1-27-23(32)14-4-6-15(7-5-14)24-28-16(13-37-24)12-35-20-8-17(33-2)9-21-18(20)10-22(36-21)19-11-31-25(29-19)38-26(30-31)34-3/h4-11,13H,12H2,1-3H3,(H,27,32)
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n/an/an/an/a 0.260n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176018
PNG
(US10047103, 51 | US9688695, 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3C[C@H](C)O[C@H](C)C3)cc(OC)cc2o1
Show InChI InChI=1S/C24H25N5O5S2/c1-13-8-28(9-14(2)33-13)22-25-15(12-35-22)11-32-19-5-16(30-3)6-20-17(19)7-21(34-20)18-10-29-23(26-18)36-24(27-29)31-4/h5-7,10,12-14H,8-9,11H2,1-4H3/t13-,14+
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n/an/an/an/a 0.260n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176039
PNG
(US10047103, 72 | US9688695, 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(N)=O)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O5S2/c1-32-16-7-19(34-11-15-12-36-23(27-15)14-5-3-13(4-6-14)22(26)31)17-9-21(35-20(17)8-16)18-10-30-24(28-18)37-25(29-30)33-2/h3-10,12H,11H2,1-2H3,(H2,26,31)
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176111
PNG
(US10047103, 144 | US9688695, 144)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(O)(C3CC3)C3CC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24N4O5S2/c1-31-16-7-19(33-11-15-12-35-22(26-15)25(30,13-3-4-13)14-5-6-14)17-9-21(34-20(17)8-16)18-10-29-23(27-18)36-24(28-29)32-2/h7-10,12-14,30H,3-6,11H2,1-2H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176134
PNG
(US10047103, 167 | US9688695, 167)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(C)CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H24N4O5S2/c1-24(4-6-31-7-5-24)21-25-14(13-34-21)12-32-18-8-15(29-2)9-19-16(18)10-20(33-19)17-11-28-22(26-17)35-23(27-28)30-3/h8-11,13H,4-7,12H2,1-3H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176007
PNG
(US10047103, 40 | US9688695, 40)
Show SMILES CNC(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C26H21N5O5S2/c1-27-23(32)14-4-6-15(7-5-14)24-28-16(13-37-24)12-35-20-8-17(33-2)9-21-18(20)10-22(36-21)19-11-31-25(29-19)38-26(30-31)34-3/h4-11,13H,12H2,1-3H3,(H,27,32)
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176018
PNG
(US10047103, 51 | US9688695, 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3C[C@H](C)O[C@H](C)C3)cc(OC)cc2o1
Show InChI InChI=1S/C24H25N5O5S2/c1-13-8-28(9-14(2)33-13)22-25-15(12-35-22)11-32-19-5-16(30-3)6-20-17(19)7-21(34-20)18-10-29-23(26-18)36-24(27-29)31-4/h5-7,10,12-14H,8-9,11H2,1-4H3/t13-,14+
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176039
PNG
(US10047103, 72 | US9688695, 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(N)=O)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O5S2/c1-32-16-7-19(34-11-15-12-36-23(27-15)14-5-3-13(4-6-14)22(26)31)17-9-21(35-20(17)8-16)18-10-30-24(28-18)37-25(29-30)33-2/h3-10,12H,11H2,1-2H3,(H2,26,31)
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176111
PNG
(US10047103, 144 | US9688695, 144)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(O)(C3CC3)C3CC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24N4O5S2/c1-31-16-7-19(33-11-15-12-35-22(26-15)25(30,13-3-4-13)14-5-6-14)17-9-21(34-20(17)8-16)18-10-29-23(27-18)36-24(28-29)32-2/h7-10,12-14,30H,3-6,11H2,1-2H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176134
PNG
(US10047103, 167 | US9688695, 167)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(C)CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H24N4O5S2/c1-24(4-6-31-7-5-24)21-25-14(13-34-21)12-32-18-8-15(29-2)9-19-16(18)10-20(33-19)17-11-28-22(26-17)35-23(27-28)30-3/h8-11,13H,4-7,12H2,1-3H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176058
PNG
(US10047103, 91 | US9688695, 91)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C(C)(C)O)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H27N5O6S2/c1-25(2,31)21-17(27-22(37-21)29-5-7-34-8-6-29)13-35-18-9-14(32-3)10-19-15(18)11-20(36-19)16-12-30-23(26-16)38-24(28-30)33-4/h9-12,31H,5-8,13H2,1-4H3
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n/an/an/an/a 0.270n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176088
PNG
(US10047103, 121 | US9688695, 121)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(O)CC(C)OC(C)C3)cc(OC)cc2o1
Show InChI InChI=1S/C25H26N4O6S2/c1-13-8-25(30,9-14(2)34-13)22-26-15(12-36-22)11-33-19-5-16(31-3)6-20-17(19)7-21(35-20)18-10-29-23(27-18)37-24(28-29)32-4/h5-7,10,12-14,30H,8-9,11H2,1-4H3
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n/an/an/an/a 0.270n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176138
PNG
(US10047103, 171 | US9688695, 171)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(CCOCC3)NS(=O)(=O)C(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C27H31N5O7S3/c1-26(2,3)42(33,34)31-27(6-8-37-9-7-27)23-28-16(15-40-23)14-38-20-10-17(35-4)11-21-18(20)12-22(39-21)19-13-32-24(29-19)41-25(30-32)36-5/h10-13,15,31H,6-9,14H2,1-5H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176259
PNG
(US10047103, 292 | US9688695, 292)
Show SMILES CCN(CCC#N)C(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C30H26N6O5S2/c1-4-35(11-5-10-31)28(37)19-8-6-18(7-9-19)27-32-20(17-42-27)16-40-24-12-21(38-2)13-25-22(24)14-26(41-25)23-15-36-29(33-23)43-30(34-36)39-3/h6-9,12-15,17H,4-5,11,16H2,1-3H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176058
PNG
(US10047103, 91 | US9688695, 91)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C(C)(C)O)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H27N5O6S2/c1-25(2,31)21-17(27-22(37-21)29-5-7-34-8-6-29)13-35-18-9-14(32-3)10-19-15(18)11-20(36-19)16-12-30-23(26-16)38-24(28-30)33-4/h9-12,31H,5-8,13H2,1-4H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176088
PNG
(US10047103, 121 | US9688695, 121)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(O)CC(C)OC(C)C3)cc(OC)cc2o1
Show InChI InChI=1S/C25H26N4O6S2/c1-13-8-25(30,9-14(2)34-13)22-26-15(12-36-22)11-33-19-5-16(31-3)6-20-17(19)7-21(35-20)18-10-29-23(27-18)37-24(28-29)32-4/h5-7,10,12-14,30H,8-9,11H2,1-4H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176138
PNG
(US10047103, 171 | US9688695, 171)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3(CCOCC3)NS(=O)(=O)C(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C27H31N5O7S3/c1-26(2,3)42(33,34)31-27(6-8-37-9-7-27)23-28-16(15-40-23)14-38-20-10-17(35-4)11-21-18(20)12-22(39-21)19-13-32-24(29-19)41-25(30-32)36-5/h10-13,15,31H,6-9,14H2,1-5H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176259
PNG
(US10047103, 292 | US9688695, 292)
Show SMILES CCN(CCC#N)C(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1
Show InChI InChI=1S/C30H26N6O5S2/c1-4-35(11-5-10-31)28(37)19-8-6-18(7-9-19)27-32-20(17-42-27)16-40-24-12-21(38-2)13-25-22(24)14-26(41-25)23-15-36-29(33-23)43-30(34-36)39-3/h6-9,12-15,17H,4-5,11,16H2,1-3H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176135
PNG
(US10047103, 168 | US9688695, 168)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3CCOc4ccccc34)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S2/c1-32-16-9-22(19-11-24(36-23(19)10-16)20-12-31-26(29-20)38-27(30-31)33-2)35-13-15-14-37-25(28-15)18-7-8-34-21-6-4-3-5-17(18)21/h3-6,9-12,14,18H,7-8,13H2,1-2H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176135
PNG
(US10047103, 168 | US9688695, 168)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C3CCOc4ccccc34)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S2/c1-32-16-9-22(19-11-24(36-23(19)10-16)20-12-31-26(29-20)38-27(30-31)33-2)35-13-15-14-37-25(28-15)18-7-8-34-21-6-4-3-5-17(18)21/h3-6,9-12,14,18H,7-8,13H2,1-2H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176091
PNG
(US10047103, 124 | US9688695, 124)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)C3(O)CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H24N4O6S2/c1-13-17(25-21(35-13)24(29)4-6-32-7-5-24)12-33-18-8-14(30-2)9-19-15(18)10-20(34-19)16-11-28-22(26-16)36-23(27-28)31-3/h8-11,29H,4-7,12H2,1-3H3
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n/an/an/an/a 0.290n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176179
PNG
(US10047103, 212 | US9688695, 212)
Show SMILES COc1cc(OCc2csc(n2)C2(F)CCOCC2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C25H23FN4O4S/c1-15-3-4-23-28-19(12-30(23)29-15)22-11-18-20(9-17(31-2)10-21(18)34-22)33-13-16-14-35-24(27-16)25(26)5-7-32-8-6-25/h3-4,9-12,14H,5-8,13H2,1-2H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176091
PNG
(US10047103, 124 | US9688695, 124)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)C3(O)CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H24N4O6S2/c1-13-17(25-21(35-13)24(29)4-6-32-7-5-24)12-33-18-8-14(30-2)9-19-15(18)10-20(34-19)16-11-28-22(26-16)36-23(27-28)31-3/h8-11,29H,4-7,12H2,1-3H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176179
PNG
(US10047103, 212 | US9688695, 212)
Show SMILES COc1cc(OCc2csc(n2)C2(F)CCOCC2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C25H23FN4O4S/c1-15-3-4-23-28-19(12-30(23)29-15)22-11-18-20(9-17(31-2)10-21(18)34-22)33-13-16-14-35-24(27-16)25(26)5-7-32-8-6-25/h3-4,9-12,14H,5-8,13H2,1-2H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176053
PNG
(US10047103, 86 | US9688695, 86)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C(F)(F)F)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C23H20F3N5O5S2/c1-32-12-7-16(35-11-15-19(23(24,25)26)37-20(28-15)30-3-5-34-6-4-30)13-9-18(36-17(13)8-12)14-10-31-21(27-14)38-22(29-31)33-2/h7-10H,3-6,11H2,1-2H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176149
PNG
(US10047103, 182 | US9688695, 182)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)(C)C)cc(F)cc2o1
Show InChI InChI=1S/C29H26FN5O4S2/c1-29(2,3)34(4)26(36)17-8-6-16(7-9-17)25-31-19(15-40-25)14-38-22-10-18(30)11-23-20(22)12-24(39-23)21-13-35-27(32-21)41-28(33-35)37-5/h6-13,15H,14H2,1-5H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176053
PNG
(US10047103, 86 | US9688695, 86)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C(F)(F)F)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C23H20F3N5O5S2/c1-32-12-7-16(35-11-15-19(23(24,25)26)37-20(28-15)30-3-5-34-6-4-30)13-9-18(36-17(13)8-12)14-10-31-21(27-14)38-22(29-31)33-2/h7-10H,3-6,11H2,1-2H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176149
PNG
(US10047103, 182 | US9688695, 182)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)(C)C)cc(F)cc2o1
Show InChI InChI=1S/C29H26FN5O4S2/c1-29(2,3)34(4)26(36)17-8-6-16(7-9-17)25-31-19(15-40-25)14-38-22-10-18(30)11-23-20(22)12-24(39-23)21-13-35-27(32-21)41-28(33-35)37-5/h6-13,15H,14H2,1-5H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176070
PNG
(US10047103, 103 | US9688695, 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCC4(CC3)OCCO4)cc(OC)cc2o1
Show InChI InChI=1S/C25H25N5O6S2/c1-31-16-9-19(17-11-21(36-20(17)10-16)18-12-30-23(27-18)38-24(28-30)32-2)33-13-15-14-37-22(26-15)29-5-3-25(4-6-29)34-7-8-35-25/h9-12,14H,3-8,13H2,1-2H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176109
PNG
(US10047103, 142 | US9688695, 142)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(C)(O)C3CCCCC3)cc(OC)cc2o1
Show InChI InChI=1S/C26H28N4O5S2/c1-26(31,15-7-5-4-6-8-15)23-27-16(14-36-23)13-34-20-9-17(32-2)10-21-18(20)11-22(35-21)19-12-30-24(28-19)37-25(29-30)33-3/h9-12,14-15,31H,4-8,13H2,1-3H3
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BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176194
PNG
(US10047103, 227 | US9688695, 227)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccnc(F)c2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C26H20FN5O3S/c1-14-4-5-25-29-19(12-32(25)31-14)23-11-18-21(9-17(33-3)10-22(18)35-23)34-13-20-15(2)36-26(30-20)16-6-7-28-24(27)8-16/h4-12H,13H2,1-3H3
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n/an/an/an/a 0.310n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176070
PNG
(US10047103, 103 | US9688695, 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)N3CCC4(CC3)OCCO4)cc(OC)cc2o1
Show InChI InChI=1S/C25H25N5O6S2/c1-31-16-9-19(17-11-21(36-20(17)10-16)18-12-30-23(27-18)38-24(28-30)32-2)33-13-15-14-37-22(26-15)29-5-3-25(4-6-29)34-7-8-35-25/h9-12,14H,3-8,13H2,1-2H3
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n/an/an/an/a 0.310n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176109
PNG
(US10047103, 142 | US9688695, 142)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(C)(O)C3CCCCC3)cc(OC)cc2o1
Show InChI InChI=1S/C26H28N4O5S2/c1-26(31,15-7-5-4-6-8-15)23-27-16(14-36-23)13-34-20-9-17(32-2)10-21-18(20)11-22(35-21)19-12-30-24(28-19)37-25(29-30)33-3/h9-12,14-15,31H,4-8,13H2,1-3H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176194
PNG
(US10047103, 227 | US9688695, 227)
Show SMILES COc1cc(OCc2nc(sc2C)-c2ccnc(F)c2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C26H20FN5O3S/c1-14-4-5-25-29-19(12-32(25)31-14)23-11-18-21(9-17(33-3)10-22(18)35-23)34-13-20-15(2)36-26(30-20)16-6-7-28-24(27)8-16/h4-12H,13H2,1-3H3
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n/an/an/an/a 0.310n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175970
PNG
(US10047103, 3 | US9688695, 3)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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n/an/an/an/a 0.320n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175995
PNG
(US10047103, 75 | US9688695, 28 | US9688695, 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-15-7-18(31-11-14-12-33-21(25-14)13-3-5-24-6-4-13)16-9-20(32-19(16)8-15)17-10-28-22(26-17)34-23(27-28)30-2/h3-10,12H,11H2,1-2H3
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n/an/an/an/a 0.320n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176072
PNG
(US10047103, 105 | US9688695, 105)
Show SMILES CCc1sc(nc1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1)N1CCOCC1
Show InChI InChI=1S/C24H25N5O5S2/c1-4-21-17(26-22(35-21)28-5-7-32-8-6-28)13-33-18-9-14(30-2)10-19-15(18)11-20(34-19)16-12-29-23(25-16)36-24(27-29)31-3/h9-12H,4-8,13H2,1-3H3
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n/an/an/an/a 0.320n/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

US Patent


Assay Description
Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...


US Patent US9688695 (2017)


BindingDB Entry DOI: 10.7270/Q28K777N
More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM176083
PNG
(US10047103, 116 | US9688695, 116)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccno3)cc(OC)cc2o1
Show InChI InChI=1S/C21H15N5O5S2/c1-27-12-5-16(29-9-11-10-32-19(23-11)15-3-4-22-31-15)13-7-18(30-17(13)6-12)14-8-26-20(24-14)33-21(25-26)28-2/h3-8,10H,9H2,1-2H3
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n/an/an/an/a 0.320n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM175970
PNG
(US10047103, 3 | US9688695, 3)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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n/an/an/an/a 0.320n/an/an/an/a



Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
PAR4


(Homo sapiens (Human))
BDBM175995
PNG
(US10047103, 75 | US9688695, 28 | US9688695, 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-15-7-18(31-11-14-12-33-21(25-14)13-3-5-24-6-4-13)16-9-20(32-19(16)8-15)17-10-28-22(26-17)34-23(27-28)30-2/h3-10,12H,11H2,1-2H3
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Bristol-Myers Squibb Company; Universite de Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US10047103 (2018)

More data for this
Ligand-Target Pair
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