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Compile Data Set for Download or QSAR

Found 4583 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret '   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 36n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Ret in human SK-M-MC cells assessed as assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 77n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Ret by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 80n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Ret in human SK-N-SH cells


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Ret in human SK-M-MC cells assessed as assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Ret by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50331094
PNG
(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O
Show InChI InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
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1.5n/an/an/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin)


J Med Chem 58: 3672-81 (2015)


Article DOI: 10.1021/jm501464c
BindingDB Entry DOI: 10.7270/Q2RR2106
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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18n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to RET (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50198782
PNG
(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)34-14-13-33-11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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407n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Ret


Bioorg Med Chem Lett 17: 602-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.006
BindingDB Entry DOI: 10.7270/Q29024MW
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of RET


J Med Chem 54: 2341-50 (2011)


Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50322535
PNG
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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n/an/a 0.900n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203458
PNG
(CHEMBL3915551)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3nnc(o3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H24ClF3N6O2/c1-36-9-11-37(12-10-36)16-19-4-6-20(14-22(19)27(29,30)31)33-24(38)17-5-7-23(28)21(13-17)26-35-34-25(39-26)18-3-2-8-32-15-18/h2-8,13-15H,9-12,16H2,1H3,(H,33,38)
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n/an/a 138n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203446
PNG
(CHEMBL3952889)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3cnc(o3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C28H25ClF3N5O2/c1-36-9-11-37(12-10-36)17-20-4-6-21(14-23(20)28(30,31)32)35-26(38)18-5-7-24(29)22(13-18)25-16-34-27(39-25)19-3-2-8-33-15-19/h2-8,13-16H,9-12,17H2,1H3,(H,35,38)
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n/an/a 19n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203447
PNG
(CHEMBL3913553)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3noc(n3)-c3ccncc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H24ClF3N6O2/c1-36-10-12-37(13-11-36)16-19-2-4-20(15-22(19)27(29,30)31)33-25(38)18-3-5-23(28)21(14-18)24-34-26(39-35-24)17-6-8-32-9-7-17/h2-9,14-15H,10-13,16H2,1H3,(H,33,38)
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n/an/a 27n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203448
PNG
(CHEMBL3961567)
Show SMILES COc1ccc(cn1)-c1nc(no1)-c1cc(ccc1Cl)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C28H26ClF3N6O3/c1-37-9-11-38(12-10-37)16-19-3-6-20(14-22(19)28(30,31)32)34-26(39)17-4-7-23(29)21(13-17)25-35-27(41-36-25)18-5-8-24(40-2)33-15-18/h3-8,13-15H,9-12,16H2,1-2H3,(H,34,39)
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n/an/a 342n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203449
PNG
(CHEMBL3925190)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3nc(co3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C28H25ClF3N5O2/c1-36-9-11-37(12-10-36)16-20-4-6-21(14-23(20)28(30,31)32)34-26(38)18-5-7-24(29)22(13-18)27-35-25(17-39-27)19-3-2-8-33-15-19/h2-8,13-15,17H,9-12,16H2,1H3,(H,34,38)
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n/an/a 21n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203450
PNG
(CHEMBL3916184)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)C#Cc3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H24ClF3N4O/c1-34-11-13-35(14-12-34)18-22-6-8-23(16-24(22)27(29,30)31)33-26(36)21-7-9-25(28)20(15-21)5-4-19-3-2-10-32-17-19/h2-3,6-10,15-17H,11-14,18H2,1H3,(H,33,36)
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n/an/a 2.5n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203451
PNG
(CHEMBL3943036)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3cccc(c3)-c3noc(n3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H25F3N6O2/c1-35-10-12-36(13-11-35)17-21-7-8-22(15-23(21)27(28,29)30)32-25(37)19-5-2-4-18(14-19)24-33-26(38-34-24)20-6-3-9-31-16-20/h2-9,14-16H,10-13,17H2,1H3,(H,32,37)
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n/an/a 18n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203452
PNG
(CHEMBL3972633)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)-c3noc(n3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C28H27F3N6O2/c1-18-5-6-19(14-23(18)25-34-27(39-35-25)20-4-3-9-32-16-20)26(38)33-22-8-7-21(24(15-22)28(29,30)31)17-37-12-10-36(2)11-13-37/h3-9,14-16H,10-13,17H2,1-2H3,(H,33,38)
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PubMed
n/an/a 108n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203453
PNG
(CHEMBL3947880)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3noc(n3)-c3cncc(c3)N3CCOCC3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C31H31ClF3N7O3/c1-40-6-8-41(9-7-40)19-21-2-4-23(16-26(21)31(33,34)35)37-29(43)20-3-5-27(32)25(15-20)28-38-30(45-39-28)22-14-24(18-36-17-22)42-10-12-44-13-11-42/h2-5,14-18H,6-13,19H2,1H3,(H,37,43)
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n/an/a 2.10n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203454
PNG
(CHEMBL3961612)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3noc(n3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H24ClF3N6O2/c1-36-9-11-37(12-10-36)16-19-4-6-20(14-22(19)27(29,30)31)33-25(38)17-5-7-23(28)21(13-17)24-34-26(39-35-24)18-3-2-8-32-15-18/h2-8,13-15H,9-12,16H2,1H3,(H,33,38)
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n/an/a 7.30n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203455
PNG
(CHEMBL3906151)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3noc(n3)-c3cncc(c3)-c3cnn(C)c3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C31H28ClF3N8O2/c1-41-7-9-43(10-8-41)18-20-3-5-24(13-26(20)31(33,34)35)38-29(44)19-4-6-27(32)25(12-19)28-39-30(45-40-28)22-11-21(14-36-15-22)23-16-37-42(2)17-23/h3-6,11-17H,7-10,18H2,1-2H3,(H,38,44)
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n/an/a 1.80n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203456
PNG
(CHEMBL3987007)
Show SMILES COCCOc1cncc(c1)-c1nc(no1)-c1cc(ccc1Cl)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C30H30ClF3N6O4/c1-39-7-9-40(10-8-39)18-20-3-5-22(15-25(20)30(32,33)34)36-28(41)19-4-6-26(31)24(14-19)27-37-29(44-38-27)21-13-23(17-35-16-21)43-12-11-42-2/h3-6,13-17H,7-12,18H2,1-2H3,(H,36,41)
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n/an/a 11n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50203457
PNG
(CHEMBL3985315)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(c3)-c3nc(no3)-c3cccnc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H24ClF3N6O2/c1-36-9-11-37(12-10-36)16-19-4-6-20(14-22(19)27(29,30)31)33-25(38)17-5-7-23(28)21(13-17)26-34-24(35-39-26)18-3-2-8-32-15-18/h2-8,13-15H,9-12,16H2,1H3,(H,33,38)
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n/an/a 12n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin) using poly[Glu:Tyr] (4:1) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 26: 5679-5684 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.061
BindingDB Entry DOI: 10.7270/Q2J1054S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM24773
PNG
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)
Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
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n/an/a 59n/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


Cancer Res 66: 8715-21 (2006)


Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25188
PNG
(3-{[3-chloro-7-(1,3-thiazol-5-yl)quinolin-4-yl]ami...)
Show SMILES Oc1cccc(Nc2c(Cl)cnc3cc(ccc23)-c2cncs2)c1
Show InChI InChI=1S/C18H12ClN3OS/c19-15-8-21-16-6-11(17-9-20-10-24-17)4-5-14(16)18(15)22-12-2-1-3-13(23)7-12/h1-10,23H,(H,21,22)
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n/an/a 100n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25189
PNG
(4-methyl-3-{[6-(pyridin-4-yl)-2-(trifluoromethyl)q...)
Show SMILES Cc1ccc(O)cc1Nc1cc(nc2ccc(cc12)-c1ccncc1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c1-13-2-4-16(29)11-19(13)27-20-12-21(22(23,24)25)28-18-5-3-15(10-17(18)20)14-6-8-26-9-7-14/h2-12,29H,1H3,(H,27,28)
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n/an/a>1.00E+3n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25190
PNG
(2-chloro-4-fluoro-5-({7-[3-({[2-(morpholin-4-yl)et...)
Show SMILES Oc1cc(Nc2ccnc3cc(ccc23)-c2cccc(CNCCN3CCOCC3)c2)c(F)cc1Cl
Show InChI InChI=1S/C28H28ClFN4O2/c29-23-16-24(30)27(17-28(23)35)33-25-6-7-32-26-15-21(4-5-22(25)26)20-3-1-2-19(14-20)18-31-8-9-34-10-12-36-13-11-34/h1-7,14-17,31,35H,8-13,18H2,(H,32,33)
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n/an/a 75n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25191
PNG
(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1
Show InChI InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22)
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n/an/a 25n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25192
PNG
(4-chloro-2-fluoro-5-({7-[2-(hydroxymethyl)-1,3-thi...)
Show SMILES OCc1nc(cs1)-c1ccc2c(Nc3cc(O)c(F)cc3Cl)ccnc2c1
Show InChI InChI=1S/C19H13ClFN3O2S/c20-12-6-13(21)18(26)7-16(12)23-14-3-4-22-15-5-10(1-2-11(14)15)17-9-27-19(8-25)24-17/h1-7,9,25-26H,8H2,(H,22,23)
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n/an/a 25n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25193
PNG
(4-methyl-3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}p...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1ccccn1
Show InChI InChI=1S/C21H17N3O/c1-14-5-7-16(25)13-20(14)24-19-9-11-23-21-12-15(6-8-17(19)21)18-4-2-3-10-22-18/h2-13,25H,1H3,(H,23,24)
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n/an/a 75n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25194
PNG
(3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}phenol | 7...)
Show SMILES Oc1cccc(Nc2ccnc3cc(ccc23)-c2ccccn2)c1
Show InChI InChI=1S/C20H15N3O/c24-16-5-3-4-15(13-16)23-19-9-11-22-20-12-14(7-8-17(19)20)18-6-1-2-10-21-18/h1-13,24H,(H,22,23)
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n/an/a 6n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25195
PNG
(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1
Show InChI InChI=1S/C21H17N3O/c1-14-4-6-17(25)12-21(14)24-20-8-10-23-19-7-5-15(11-18(19)20)16-3-2-9-22-13-16/h2-13,25H,1H3,(H,23,24)
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n/an/a 80n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25196
PNG
(4-[(5-hydroxy-2-methylphenyl)amino]-N-(propan-2-yl...)
Show SMILES CC(C)NC(=O)c1ccc2nccc(Nc3cc(O)ccc3C)c2c1
Show InChI InChI=1S/C20H21N3O2/c1-12(2)22-20(25)14-5-7-17-16(10-14)18(8-9-21-17)23-19-11-15(24)6-4-13(19)3/h4-12,24H,1-3H3,(H,21,23)(H,22,25)
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n/an/a 95n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25197
PNG
(6-substituted 4-anilinoquinoline, 37 | N-(cyclopro...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C20H21N3O3S/c1-13-2-5-15(24)10-20(13)23-19-8-9-21-18-7-6-16(11-17(18)19)27(25,26)22-12-14-3-4-14/h2,5-11,14,22,24H,3-4,12H2,1H3,(H,21,23)
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n/an/a 90n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25198
PNG
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)S(C)(=O)=O
Show InChI InChI=1S/C17H16N2O3S/c1-11-3-4-12(20)9-17(11)19-16-7-8-18-15-6-5-13(10-14(15)16)23(2,21)22/h3-10,20H,1-2H3,(H,18,19)
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n/an/a 3n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25199
PNG
(5-{[7-(1-benzofuran-2-yl)quinolin-4-yl]amino}-2-br...)
Show SMILES Oc1cc(Nc2ccnc3cc(ccc23)-c2cc3ccccc3o2)ccc1Br
Show InChI InChI=1S/C23H15BrN2O2/c24-18-8-6-16(13-21(18)27)26-19-9-10-25-20-11-15(5-7-17(19)20)23-12-14-3-1-2-4-22(14)28-23/h1-13,27H,(H,25,26)
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n/an/a 85n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25200
PNG
(3-({6-methanesulfonyl-7-[2-(morpholin-4-ylmethyl)-...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(-c3csc(CN4CCOCC4)n3)c(cc12)S(C)(=O)=O
Show InChI InChI=1S/C25H26N4O4S2/c1-16-3-4-17(30)11-21(16)27-20-5-6-26-22-12-19(24(13-18(20)22)35(2,31)32)23-15-34-25(28-23)14-29-7-9-33-10-8-29/h3-6,11-13,15,30H,7-10,14H2,1-2H3,(H,26,27)
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n/an/a 34n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM25201
PNG
(4-Anilino-6,7-disubstituted quinoline, 41 | 4-chlo...)
Show SMILES Oc1cc(Nc2ccnc3cc(-c4ccc(CN5CCOCC5)o4)c(Cl)cc23)c(Cl)cc1F
Show InChI InChI=1S/C24H20Cl2FN3O3/c25-17-9-16-20(29-22-12-23(31)19(27)11-18(22)26)3-4-28-21(16)10-15(17)24-2-1-14(33-24)13-30-5-7-32-8-6-30/h1-4,9-12,31H,5-8,13H2,(H,28,29)
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n/an/a>1.00E+3n/an/an/an/a7.422



GlaxoSmithKline



Assay Description
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...


Bioorg Med Chem Lett 17: 5886-93 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.104
BindingDB Entry DOI: 10.7270/Q2H1309S
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112774
PNG
(US8629135, SW-01)
Show SMILES CN(C)CCC=C1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3
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n/an/a 300n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES CN(C)CCC=C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112777
PNG
(NORTRIPTYLINE | US8629135, SW-02)
Show SMILES CNCCC=C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
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n/an/a 1.50E+3n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112775
PNG
(US8629135, SW-13)
Show SMILES CN(C)CCOC1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C19H21NO/c1-20(2)13-14-21-19-17-9-5-3-7-15(17)11-12-16-8-4-6-10-18(16)19/h3-12,19H,13-14H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112776
PNG
(US8629135, SW-12)
Show SMILES CCN(CC)CCCOC(=O)CC1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C24H29NO2/c1-3-25(4-2)16-9-17-27-24(26)18-23-21-12-7-5-10-19(21)14-15-20-11-6-8-13-22(20)23/h5-8,10-15,23H,3-4,9,16-18H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50097219
PNG
(C-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-...)
Show SMILES NCC1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C16H17N/c17-11-16-14-7-3-1-5-12(14)9-10-13-6-2-4-8-15(13)16/h1-8,16H,9-11,17H2
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n/an/a 5.00E+3n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112777
PNG
(NORTRIPTYLINE | US8629135, SW-02)
Show SMILES CNCCC=C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
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n/an/a 5.00E+3n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112778
PNG
(US8629135, SW-03)
Show SMILES C[N+](C)([O-])CCC=C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112779
PNG
(US8629135, SW-11)
Show SMILES CN(C)CCCC1(O)c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C20H23NO/c1-21(2)15-7-14-20(22)18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)20/h3-6,8-13,22H,7,14-15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM82437
PNG
(CAS_23047-25-8 | Lofepramine | NSC_3947 | US862913...)
Show SMILES CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
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n/an/a>2.00E+4n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112780
PNG
(US8629135, SW-07)
Show SMILES CN(C)CC\C=C1/c2ccccc2COc2ccccc12
Show InChI InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11+
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n/an/a>2.00E+4n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM112781
PNG
(US8629135, SW-09)
Show SMILES CN(C)CCNC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C17H20N2/c1-19(2)12-11-18-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,17-18H,11-12H2,1-2H3
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n/an/a>2.00E+4n/an/an/an/a7.430



Queen's University at Kingston

US Patent


Assay Description
Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...


US Patent US8629135 (2014)


BindingDB Entry DOI: 10.7270/Q2R78CVN
More data for this
Ligand-Target Pair
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