Found 593 hits Enz. Inhib. hit(s) with Target = 'Retinoic acid receptor beta' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032218
(5-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)Show SMILES C\C(=C/c1ccc(o1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C Show InChI InChI=1S/C23H28O3/c1-14(11-16-7-8-20(26-16)21(24)25)17-13-19-18(12-15(17)2)22(3,4)9-10-23(19,5)6/h7-8,11-13H,9-10H2,1-6H3,(H,24,25)/b14-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | >0.00100 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 38: 2820-9 (1995)
Article DOI: 10.1021/jm00015a004
BindingDB Entry DOI: 10.7270/Q2FN157S |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032225
(5-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)Show SMILES C\C(=C/c1cc(cs1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C Show InChI InChI=1S/C23H28O2S/c1-14(9-17-11-16(13-26-17)21(24)25)18-12-20-19(10-15(18)2)22(3,4)7-8-23(20,5)6/h9-13H,7-8H2,1-6H3,(H,24,25)/b14-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | >0.00100 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 38: 2820-9 (1995)
Article DOI: 10.1021/jm00015a004
BindingDB Entry DOI: 10.7270/Q2FN157S |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032224
(3-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)Show SMILES C\C(=C/c1cccc(c1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H30O2/c1-16(12-18-8-7-9-19(14-18)23(26)27)20-15-22-21(13-17(20)2)24(3,4)10-11-25(22,5)6/h7-9,12-15H,10-11H2,1-6H3,(H,26,27)/b16-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >0.00100 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 38: 2820-9 (1995)
Article DOI: 10.1021/jm00015a004
BindingDB Entry DOI: 10.7270/Q2FN157S |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50265920
(4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H24O2/c1-22(2)13-14-23(3,4)20-15-17(9-12-19(20)22)6-5-16-7-10-18(11-8-16)21(24)25/h7-12,15H,13-14H2,1-4H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
University of Lille
Curated by ChEMBL
| Assay Description
Activity at human RARbeta ligand binding domain expressed in COS7 cells cotransfected with Gal4-DBD assessed as transcriptional activation after 16 h... |
Bioorg Med Chem Lett 19: 489-92 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.040
BindingDB Entry DOI: 10.7270/Q2GF0TC9 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM323587
(4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2...)Show SMILES CC(=Cc1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| PC cid
PC sid
PDB
UniChem
| PDB
US Patent
| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
ACUCELA INC.
US Patent
| Assay Description
Retinoid nuclear receptor activity is associated with transduction of the non-visual physiologic, pharmacologic, and toxicologic retinoid signals tha... |
US Patent US10188615 (2019)
BindingDB Entry DOI: 10.7270/Q2NP26HC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50282692
(4-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...)Show SMILES CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12 Show InChI InChI=1S/C23H26O2/c1-22(2)13-14-23(3,4)20-15-17(9-12-19(20)22)6-5-16-7-10-18(11-8-16)21(24)25/h5-12,15H,13-14H2,1-4H3,(H,24,25)/b6-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation for RAR beta receptor |
Bioorg Med Chem Lett 4: 1447-1452 (1994)
Article DOI: 10.1016/S0960-894X(01)80511-4
BindingDB Entry DOI: 10.7270/Q2B8582K |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50282691
(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)Show SMILES Cc1cc2c(cc1\C=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)11-8-17-6-9-18(10-7-17)22(25)26/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b11-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation for RAR beta receptor |
Bioorg Med Chem Lett 4: 1447-1452 (1994)
Article DOI: 10.1016/S0960-894X(01)80511-4
BindingDB Entry DOI: 10.7270/Q2B8582K |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50045276
(4-[(E)-1-Methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tet...)Show SMILES C\C(=C/c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H28O2/c1-16(18-7-9-19(10-8-18)22(25)26)14-17-6-11-20-21(15-17)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation for RAR beta receptor |
Bioorg Med Chem Lett 4: 1447-1452 (1994)
Article DOI: 10.1016/S0960-894X(01)80511-4
BindingDB Entry DOI: 10.7270/Q2B8582K |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
| Purchase
CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
PubMed
| n/a | n/a | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of mouse Gal4-fused RARbeta-LBD expressed in COS-7 cells after 1 day by bright-Glo reagent based assay |
Bioorg Med Chem 26: 798-814 (2018)
Article DOI: 10.1016/j.bmc.2017.12.015
BindingDB Entry DOI: 10.7270/Q2WH2SKR |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50265951
(CHEMBL1657 | TAZAROTENE | US9963439, Tazarotene | ...)Show InChI InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| Purchase
CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem
Patents
| DrugBank
Article
PubMed
| n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
University of Lille
Curated by ChEMBL
| Assay Description
Activity at human RARbeta ligand binding domain expressed in COS7 cells cotransfected with Gal4-DBD assessed as transcriptional activation after 16 h... |
Bioorg Med Chem Lett 19: 489-92 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.040
BindingDB Entry DOI: 10.7270/Q2GF0TC9 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM50048292
(6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...)Show SMILES COc1ccc(cc1C1(C)CCCCC1)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C25H26O3/c1-25(12-4-3-5-13-25)22-16-20(10-11-23(22)28-2)18-6-7-19-15-21(24(26)27)9-8-17(19)14-18/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.830 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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GoogleScholar
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CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 38: 4764-7 (1996)
Article DOI: 10.1021/jm00024a003
BindingDB Entry DOI: 10.7270/Q22N5194 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
| Purchase
CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation... |
Bioorg Med Chem Lett 6: 213-218 (1996)
Article DOI: 10.1016/0960-894X(95)00588-K
BindingDB Entry DOI: 10.7270/Q2BC3ZHZ |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
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CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
PubMed
| n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM50526321
(CHEMBL4572914)Show SMILES CC(C)(C)c1cc(cc(c1)C(C)(C)C)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H26N2O3/c1-22(2,3)17-11-16(12-18(13-17)23(4,5)6)20-24-19(25-28-20)14-7-9-15(10-8-14)21(26)27/h7-13H,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| Purchase
CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation of retinoic acid receptor RAR beta |
Bioorg Med Chem Lett 5: 523-527 (1995)
Article DOI: 10.1016/0960-894X(95)00065-2
BindingDB Entry DOI: 10.7270/Q20G3K4D |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
| Purchase
CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
Università di Ferrara
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 42: 4961-9 (2000)
Article DOI: 10.1021/jm991059n
BindingDB Entry DOI: 10.7270/Q24F1PX3 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM50526311
(CHEMBL4588745)Show SMILES CCOc1c(Cl)cc(cc1Cl)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-2-24-14-12(18)7-11(8-13(14)19)16-20-15(21-25-16)9-3-5-10(6-4-9)17(22)23/h3-8H,2H2,1H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation for RAR beta receptor |
Bioorg Med Chem Lett 4: 1447-1452 (1994)
Article DOI: 10.1016/S0960-894X(01)80511-4
BindingDB Entry DOI: 10.7270/Q2B8582K |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| MMDB
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| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 38: 2820-9 (1995)
Article DOI: 10.1021/jm00015a004
BindingDB Entry DOI: 10.7270/Q2FN157S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM50526314
(CHEMBL4459692)Show SMILES Cc1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O4/c1-10-3-4-11(2)16-14(10)9-15(24-16)18-20-17(21-25-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23) | PDB
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King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50048280
(6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic ac...)Show SMILES COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30) | PDB
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Nestle Skin Health
Curated by ChEMBL
| Assay Description
Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs... |
Bioorg Med Chem Lett 28: 1736-1741 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.036
BindingDB Entry DOI: 10.7270/Q2N300JQ |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| MMDB
Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham
Curated by ChEMBL
| Assay Description
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta |
J Med Chem 41: 1679-87 (1998)
Article DOI: 10.1021/jm970635h
BindingDB Entry DOI: 10.7270/Q20864F4 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50097824
(4-[(E)-4-(2,6,6-Trimethyl-cyclohex-1-enyl)-but-3-e...)Show InChI InChI=1S/C20H22O2/c1-15-7-6-14-20(2,3)18(15)9-5-4-8-16-10-12-17(13-11-16)19(21)22/h5,9-13H,6-7,14H2,1-3H3,(H,21,22)/b9-5+ | PDB
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| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation of retinoic acid receptor RAR beta |
Bioorg Med Chem Lett 5: 523-527 (1995)
Article DOI: 10.1016/0960-894X(95)00065-2
BindingDB Entry DOI: 10.7270/Q20G3K4D |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50526314
(CHEMBL4459692)Show SMILES Cc1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O4/c1-10-3-4-11(2)16-14(10)9-15(24-16)18-20-17(21-25-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23) | PDB
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| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4 DBD-fused human RARbeta-LBD expressed in HEK293 cells by beta-lactamase reporter gene based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM50526312
(CHEMBL4449668)Show SMILES Cc1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(C(O)=O)c(F)c1 Show InChI InChI=1S/C19H13FN2O4/c1-9-3-4-10(2)16-13(9)8-15(25-16)18-21-17(22-26-18)11-5-6-12(19(23)24)14(20)7-11/h3-8H,1-2H3,(H,23,24) | PDB
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Reactome pathway
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King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50052033
((2E,4E,6E)-7-(3,5-Di-tert-butyl-phenyl)-3-methyl-o...)Show SMILES C\C(\C=C\C=C(/C)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)=C/C(O)=O Show InChI InChI=1S/C23H32O2/c1-16(12-21(24)25)10-9-11-17(2)18-13-19(22(3,4)5)15-20(14-18)23(6,7)8/h9-15H,1-8H3,(H,24,25)/b10-9+,16-12+,17-11+ | PDB
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| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 39: 2659-63 (1996)
Article DOI: 10.1021/jm960285j
BindingDB Entry DOI: 10.7270/Q2988631 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50052033
((2E,4E,6E)-7-(3,5-Di-tert-butyl-phenyl)-3-methyl-o...)Show SMILES C\C(\C=C\C=C(/C)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)=C/C(O)=O Show InChI InChI=1S/C23H32O2/c1-16(12-21(24)25)10-9-11-17(2)18-13-19(22(3,4)5)15-20(14-18)23(6,7)8/h9-15H,1-8H3,(H,24,25)/b10-9+,16-12+,17-11+ | PDB
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| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 39: 2659-63 (1996)
Article DOI: 10.1021/jm960285j
BindingDB Entry DOI: 10.7270/Q2988631 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50457542
(CHEMBL4212472)Show InChI InChI=1S/C19H17NO2S/c1-19(2)10-11-23-17-9-7-13(12-15(17)19)6-8-14-4-3-5-16(20-14)18(21)22/h3-5,7,9,12H,10-11H2,1-2H3,(H,21,22) | PDB
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Nestle Skin Health
Curated by ChEMBL
| Assay Description
Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs... |
Bioorg Med Chem Lett 28: 1736-1741 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.036
BindingDB Entry DOI: 10.7270/Q2N300JQ |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor beta
(Mus musculus) | BDBM50526315
(CHEMBL4439399)Show SMILES OC(=O)c1ccc(cc1)-c1noc(n1)-c1cc2c(ccc(F)c2o1)C(F)(F)F Show InChI InChI=1S/C18H8F4N2O4/c19-12-6-5-11(18(20,21)22)10-7-13(27-14(10)12)16-23-15(24-28-16)8-1-3-9(4-2-8)17(25)26/h1-7H,(H,25,26) | PDB
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King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50290184
(4-(1-Isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-qui...)Show SMILES CC(C)N1CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H25NO2/c1-16(2)24-14-13-23(3,4)20-12-9-18(15-21(20)24)6-5-17-7-10-19(11-8-17)22(25)26/h7-12,15-16H,13-14H2,1-4H3,(H,25,26) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity of the compound was determined for Retinoic acid receptor alpha |
Bioorg Med Chem Lett 7: 2373-2378 (1997)
Article DOI: 10.1016/S0960-894X(97)00435-6
BindingDB Entry DOI: 10.7270/Q2K35TN8 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB
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Article
PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta |
J Med Chem 44: 2298-303 (2001)
Article DOI: 10.1021/jm0100584
BindingDB Entry DOI: 10.7270/Q2P84B41 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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TBA
Curated by ChEMBL
| Assay Description
Transactivation potency of the compound was determined for Retinoic acid receptor beta |
Bioorg Med Chem Lett 7: 2373-2378 (1997)
Article DOI: 10.1016/S0960-894X(97)00435-6
BindingDB Entry DOI: 10.7270/Q2K35TN8 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Binding affinity against retinoic Acid beta receptors cotransfected into CV-1 cells |
J Med Chem 37: 408-14 (1994)
Article DOI: 10.1021/jm00029a013
BindingDB Entry DOI: 10.7270/Q20V8BT5 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay |
Bioorg Med Chem Lett 5: 2729-2734 (1995)
Article DOI: 10.1016/0960-894X(95)00455-3
BindingDB Entry DOI: 10.7270/Q22N527N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB
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| DrugBank
PDB
Article
| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation for RAR beta receptor |
Bioorg Med Chem Lett 4: 1447-1452 (1994)
Article DOI: 10.1016/S0960-894X(01)80511-4
BindingDB Entry DOI: 10.7270/Q2B8582K |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50064254
((2E,4E,6E,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-cycl...)Show SMILES C\C(\C=C/C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11-,15-8+,16-14+ | PDB
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| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation of retinoic acid receptor RAR beta |
Bioorg Med Chem Lett 5: 523-527 (1995)
Article DOI: 10.1016/0960-894X(95)00065-2
BindingDB Entry DOI: 10.7270/Q20G3K4D |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB
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PubMed
| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 38: 2820-9 (1995)
Article DOI: 10.1021/jm00015a004
BindingDB Entry DOI: 10.7270/Q2FN157S |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB
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| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
Università di Ferrara
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 42: 4961-9 (2000)
Article DOI: 10.1021/jm991059n
BindingDB Entry DOI: 10.7270/Q24F1PX3 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoic acid receptor beta
(Mus musculus) | BDBM50526325
(CHEMBL4438880)Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23) | PDB
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| n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
King's College
Curated by ChEMBL
| Assay Description
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay |
Bioorg Med Chem Lett 29: 995-1000 (2019)
Article DOI: 10.1016/j.bmcl.2019.02.011 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50457552
(CHEMBL4210595)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)-c1cc(ccc1OCCCO)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C30H34O4/c1-29(2)14-15-30(3,4)26-19-23(10-12-25(26)29)24-18-22(11-13-27(24)34-17-5-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,5,14-17H2,1-4H3,(H,32,33) | PDB
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| n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
Nestle Skin Health
Curated by ChEMBL
| Assay Description
Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs... |
Bioorg Med Chem Lett 28: 1736-1741 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.036
BindingDB Entry DOI: 10.7270/Q2N300JQ |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Allergan Inc
Curated by ChEMBL
| Assay Description
Transcriptional activation of Retinoic acid receptor RAR beta |
J Med Chem 38: 2820-9 (1995)
Article DOI: 10.1021/jm00015a004
BindingDB Entry DOI: 10.7270/Q2FN157S |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation for RAR beta receptor |
Bioorg Med Chem Lett 4: 1447-1452 (1994)
Article DOI: 10.1016/S0960-894X(01)80511-4
BindingDB Entry DOI: 10.7270/Q2B8582K |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50290178
(4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahyd...)Show SMILES CC(C)N1C(=O)CC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H23NO3/c1-15(2)24-20-13-17(9-12-19(20)23(3,4)14-21(24)25)6-5-16-7-10-18(11-8-16)22(26)27/h7-13,15H,14H2,1-4H3,(H,26,27) | PDB
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| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transactivation potency of the compound was determined for Retinoic acid receptor beta |
Bioorg Med Chem Lett 7: 2373-2378 (1997)
Article DOI: 10.1016/S0960-894X(97)00435-6
BindingDB Entry DOI: 10.7270/Q2K35TN8 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50290179
(4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahyd...)Show SMILES CC(C)N1C(=O)CC(C)(C)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H23NO3/c1-15(2)24-20-12-9-17(13-19(20)23(3,4)14-21(24)25)6-5-16-7-10-18(11-8-16)22(26)27/h7-13,15H,14H2,1-4H3,(H,26,27) | PDB
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| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity of the compound was determined for Retinoic acid receptor beta |
Bioorg Med Chem Lett 7: 2373-2378 (1997)
Article DOI: 10.1016/S0960-894X(97)00435-6
BindingDB Entry DOI: 10.7270/Q2K35TN8 |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation of retinoic acid receptor RAR beta |
Bioorg Med Chem Lett 5: 523-527 (1995)
Article DOI: 10.1016/0960-894X(95)00065-2
BindingDB Entry DOI: 10.7270/Q20G3K4D |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50286563
(6-[(E)-4-(2,6,6-Trimethyl-cyclohex-1-enyl)-but-3-e...)Show InChI InChI=1S/C19H21NO2/c1-14-7-6-12-19(2,3)17(14)9-5-4-8-16-11-10-15(13-20-16)18(21)22/h5,9-11,13H,6-7,12H2,1-3H3,(H,21,22)/b9-5+ | PDB
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| n/a | n/a | n/a | n/a | >5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Transcriptional activation of retinoic acid receptor RAR beta |
Bioorg Med Chem Lett 5: 523-527 (1995)
Article DOI: 10.1016/0960-894X(95)00065-2
BindingDB Entry DOI: 10.7270/Q20G3K4D |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50457546
(CHEMBL4206237)Show SMILES COc1ccc(cc1-c1ccc2c(c1)C(C)(C)CCC2(C)C)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C28H30O3/c1-27(2)14-15-28(3,4)24-17-21(10-12-23(24)27)22-16-20(11-13-25(22)31-5)18-6-8-19(9-7-18)26(29)30/h6-13,16-17H,14-15H2,1-5H3,(H,29,30) | PDB
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| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Nestle Skin Health
Curated by ChEMBL
| Assay Description
Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs... |
Bioorg Med Chem Lett 28: 1736-1741 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.036
BindingDB Entry DOI: 10.7270/Q2N300JQ |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50045267
(4-[2-Methyl-4-(2,6,6-trimethyl-cyclohex-1-enyl)-bu...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/c1ccc(cc1)C(O)=O Show InChI InChI=1S/C21H26O2/c1-15(14-17-8-10-18(11-9-17)20(22)23)7-12-19-16(2)6-5-13-21(19,3)4/h7-12,14H,5-6,13H2,1-4H3,(H,22,23)/b12-7+,15-14+ | PDB
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| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
SRI International
Curated by ChEMBL
| Assay Description
Effective concentration against Retinoic acid receptor beta |
J Med Chem 36: 2605-13 (1993)
Article DOI: 10.1021/jm00070a003
BindingDB Entry DOI: 10.7270/Q21R6PKP |
More data for this
Ligand-Target Pair | |
Retinoid receptor
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
SRI International
Curated by ChEMBL
| Assay Description
Effective concentration against Retinoic acid receptor beta |
J Med Chem 36: 2605-13 (1993)
Article DOI: 10.1021/jm00070a003
BindingDB Entry DOI: 10.7270/Q21R6PKP |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
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