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Compile Data Set for Download or QSAR

Found 593 hits Enz. Inhib. hit(s) with Target = 'Retinol-binding protein 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50347597
PNG
(CHEMBL60405)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)NCCO
Show InChI InChI=1S/C22H33NO2/c1-17(8-6-9-18(2)16-21(25)23-14-15-24)11-12-20-19(3)10-7-13-22(20,4)5/h6,8-9,11-12,16,24H,7,10,13-15H2,1-5H3,(H,23,25)/b9-6+,12-11+,17-8+,18-16+
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n/an/an/an/a 145n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50347599
PNG
(CHEMBL1802454)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)N1CCOCC1
Show InChI InChI=1S/C24H35NO2/c1-19(11-12-22-21(3)10-7-13-24(22,4)5)8-6-9-20(2)18-23(26)25-14-16-27-17-15-25/h6,8-9,11-12,18H,7,10,13-17H2,1-5H3/b9-6+,12-11+,19-8+,20-18+
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n/an/an/an/a 154n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50347596
PNG
(CHEMBL1803043)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)NCC(O)CO
Show InChI InChI=1S/C23H35NO3/c1-17(11-12-21-19(3)10-7-13-23(21,4)5)8-6-9-18(2)14-22(27)24-15-20(26)16-25/h6,8-9,11-12,14,20,25-26H,7,10,13,15-16H2,1-5H3,(H,24,27)/b9-6+,12-11+,17-8+,18-14+
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n/an/an/an/a 171n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50347595
PNG
(CHEMBL58106)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C\C(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18-
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n/an/an/an/a 245n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50347598
PNG
(CHEMBL1802450)
Show SMILES CN(C)c1ccc(NC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C2=C(C)CCCC2(C)C)cc1
Show InChI InChI=1S/C28H38N2O/c1-21(13-18-26-23(3)12-9-19-28(26,4)5)10-8-11-22(2)20-27(31)29-24-14-16-25(17-15-24)30(6)7/h8,10-11,13-18,20H,9,12,19H2,1-7H3,(H,29,31)/b11-8+,18-13+,21-10+,22-20+
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n/an/an/an/a 954n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50347594
PNG
(CHEMBL1801542)
Show SMILES COC(=O)COc1ccc(NC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C2=C(C)CCCC2(C)C)cc1
Show InChI InChI=1S/C29H37NO4/c1-21(12-17-26-23(3)11-8-18-29(26,4)5)9-7-10-22(2)19-27(31)30-24-13-15-25(16-14-24)34-20-28(32)33-6/h7,9-10,12-17,19H,8,11,18,20H2,1-6H3,(H,30,31)/b10-7+,17-12+,21-9+,22-19+
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n/an/an/an/a 1.26E+3n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM50092055
PNG
((2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cycl...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
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n/an/an/an/a 2.37E+3n/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein inter...


J Med Chem 54: 4378-87 (2011)


Article DOI: 10.1021/jm200256g
BindingDB Entry DOI: 10.7270/Q2D21XZ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106681
PNG
(US8586571, 6)
Show SMILES CC(C)(C)c1cc(F)ccc1OC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H21FN2O2/c1-19(2,3)15-10-13(20)7-8-17(15)24-14-11-22(12-14)18(23)16-6-4-5-9-21-16/h4-10,14H,11-12H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106682
PNG
(US8586571, 36)
Show SMILES CC(C)(C)c1ccccc1OC1CN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C16H21NO4/c1-16(2,3)12-6-4-5-7-13(12)21-11-9-17(10-11)14(18)8-15(19)20/h4-7,11H,8-10H2,1-3H3,(H,19,20)
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n/an/a 36n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106683
PNG
(US8586571, 12)
Show SMILES CC(C)(C)c1ccccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H23NO4/c1-17(2,3)13-6-4-5-7-14(13)22-12-10-18(11-12)15(19)8-9-16(20)21/h4-7,12H,8-11H2,1-3H3,(H,20,21)
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n/an/a 210n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106684
PNG
(US8586571, 14)
Show SMILES CC(C)(C)c1ccccc1OC1CN(C1)C(=O)C1(CC1)C(O)=O
Show InChI InChI=1S/C18H23NO4/c1-17(2,3)13-6-4-5-7-14(13)23-12-10-19(11-12)15(20)18(8-9-18)16(21)22/h4-7,12H,8-11H2,1-3H3,(H,21,22)
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n/an/a 24n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106685
PNG
(US8586571, 17)
Show SMILES CC(C)(C)c1ccccc1SC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H22N2OS/c1-19(2,3)15-8-4-5-10-17(15)23-14-12-21(13-14)18(22)16-9-6-7-11-20-16/h4-11,14H,12-13H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106686
PNG
(US8586571, 20)
Show SMILES CC(C)(C)c1ccccc1S(=O)(=O)C1CN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C20H23NO3S/c1-20(2,3)17-11-7-8-12-18(17)25(23,24)16-13-21(14-16)19(22)15-9-5-4-6-10-15/h4-12,16H,13-14H2,1-3H3
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n/an/a 290n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106687
PNG
(US8586571, 50)
Show SMILES CC(C)(C)c1ccccc1OC1CCN(CC1)C(=O)c1ccccn1
Show InChI InChI=1S/C21H26N2O2/c1-21(2,3)17-8-4-5-10-19(17)25-16-11-14-23(15-12-16)20(24)18-9-6-7-13-22-18/h4-10,13,16H,11-12,14-15H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106688
PNG
(US8586571, 80)
Show SMILES CC(C)(C)c1cc(F)ccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H22FNO4/c1-17(2,3)13-8-11(18)4-5-14(13)23-12-9-19(10-12)15(20)6-7-16(21)22/h4-5,8,12H,6-7,9-10H2,1-3H3,(H,21,22)
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n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106689
PNG
(US8586571, 121)
Show SMILES CCCCCS(=O)(=O)NC(=O)C(=O)N1CCC(COc2ccccc2C(C)(C)C)CC1
Show InChI InChI=1S/C23H36N2O5S/c1-5-6-9-16-31(28,29)24-21(26)22(27)25-14-12-18(13-15-25)17-30-20-11-8-7-10-19(20)23(2,3)4/h7-8,10-11,18H,5-6,9,12-17H2,1-4H3,(H,24,26)
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n/an/a 790n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106690
PNG
(US8586571, 143)
Show SMILES CC(C)(C)c1cc(F)ccc1OCC1CN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H22FNO4/c1-17(2,3)13-6-12(18)4-5-14(13)23-10-11-8-19(9-11)15(20)7-16(21)22/h4-6,11H,7-10H2,1-3H3,(H,21,22)
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n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106691
PNG
(US8586571, 164)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2,3)15-10-13(20)7-8-17(15)24-14-11-22(12-14)18(23)16-6-4-5-9-21-16/h4-10,14H,11-12H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106692
PNG
(US8586571, 189)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H22ClNO4/c1-17(2,3)13-8-11(18)4-5-14(13)23-12-9-19(10-12)15(20)6-7-16(21)22/h4-5,8,12H,6-7,9-10H2,1-3H3,(H,21,22)
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n/an/a 71n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106693
PNG
(US8586571, 197)
Show SMILES CC(C)(C)c1ccccc1OCC1CCN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C18H25NO4/c1-18(2,3)14-6-4-5-7-15(14)23-12-13-8-9-19(11-13)16(20)10-17(21)22/h4-7,13H,8-12H2,1-3H3,(H,21,22)
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n/an/a 40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106694
PNG
(US8586571, 207)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OCC1CN(C1)C(=O)C(O)=O
Show InChI InChI=1S/C16H20ClNO4/c1-16(2,3)12-6-11(17)4-5-13(12)22-9-10-7-18(8-10)14(19)15(20)21/h4-6,10H,7-9H2,1-3H3,(H,20,21)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM106695
PNG
(US8586571, 215)
Show SMILES CC(C)(C)c1cc(F)ccc1OCC1CCN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C18H24FNO4/c1-18(2,3)14-8-13(19)4-5-15(14)24-11-12-6-7-20(10-12)16(21)9-17(22)23/h4-5,8,12H,6-7,9-11H2,1-3H3,(H,22,23)
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135841
PNG
(US8853215, 1)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C12CC3CC(CC(C3)(C1)C(O)=O)C2
Show InChI InChI=1S/C26H36N2O3/c1-24(2,3)20-6-4-5-7-21(20)27-8-10-28(11-9-27)22(29)25-13-18-12-19(14-25)16-26(15-18,17-25)23(30)31/h4-7,18-19H,8-17H2,1-3H3,(H,30,31)
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n/an/a 95n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135825
PNG
(US8853215, 3)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1c[nH]cn1
Show InChI InChI=1S/C18H24N4O/c1-18(2,3)14-6-4-5-7-16(14)21-8-10-22(11-9-21)17(23)15-12-19-13-20-15/h4-7,12-13H,8-11H2,1-3H3,(H,19,20)
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n/an/a 3.80n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135826
PNG
(US8853215, 6)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)NCC(O)=O
Show InChI InChI=1S/C17H25N3O3/c1-17(2,3)13-6-4-5-7-14(13)19-8-10-20(11-9-19)16(23)18-12-15(21)22/h4-7H,8-12H2,1-3H3,(H,18,23)(H,21,22)
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n/an/a 540n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135827
PNG
(US8853215, 9)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H24N2O3/c1-17(2,3)13-6-4-5-7-14(13)18-8-10-19(11-9-18)15(20)12-16(21)22/h4-7H,8-12H2,1-3H3,(H,21,22)
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n/an/a 54n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135828
PNG
(US8853215, 19)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1ccc(cc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C23H26N4O3/c1-23(2,3)18-6-4-5-7-19(18)26-12-14-27(15-13-26)21(28)17-10-8-16(9-11-17)20-24-22(29)30-25-20/h4-11H,12-15H2,1-3H3,(H,24,25,29)
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n/an/a 49n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135829
PNG
(US8853215, 34)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H26N2O3/c1-22(2,3)18-6-4-5-7-19(18)23-12-14-24(15-13-23)20(25)16-8-10-17(11-9-16)21(26)27/h4-11H,12-15H2,1-3H3,(H,26,27)
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n/an/a 480n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135830
PNG
(US8853215, 39)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(=O)NS(=O)(=O)NCC1CC1
Show InChI InChI=1S/C20H30N4O4S/c1-20(2,3)16-6-4-5-7-17(16)23-10-12-24(13-11-23)19(26)18(25)22-29(27,28)21-14-15-8-9-15/h4-7,15,21H,8-14H2,1-3H3,(H,22,25)
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n/an/a 430n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135831
PNG
(US8853215, 41)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1ccc(OCC2CCNCC2)cc1
Show InChI InChI=1S/C27H37N3O2/c1-27(2,3)24-6-4-5-7-25(24)29-16-18-30(19-17-29)26(31)22-8-10-23(11-9-22)32-20-21-12-14-28-15-13-21/h4-11,21,28H,12-20H2,1-3H3
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n/an/a 250n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135832
PNG
(US8853215, 44)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(O)=O
Show InChI InChI=1S/C16H22N2O3/c1-16(2,3)12-6-4-5-7-13(12)17-8-10-18(11-9-17)14(19)15(20)21/h4-7H,8-11H2,1-3H3,(H,20,21)
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n/an/a 38n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135833
PNG
(US8853215, 55)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)CCC(=O)NS(C)(=O)=O
Show InChI InChI=1S/C19H29N3O4S/c1-19(2,3)15-7-5-6-8-16(15)21-11-13-22(14-12-21)18(24)10-9-17(23)20-27(4,25)26/h5-8H,9-14H2,1-4H3,(H,20,23)
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n/an/a 64n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135834
PNG
(US8853215, 56)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C21H27N3O/c1-21(2,3)18-11-7-8-12-19(18)23-13-15-24(16-14-23)20(25)22-17-9-5-4-6-10-17/h4-12H,13-16H2,1-3H3,(H,22,25)
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n/an/a 58n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135835
PNG
(US8853215, 58)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)Cc1nnn[nH]1
Show InChI InChI=1S/C17H24N6O/c1-17(2,3)13-6-4-5-7-14(13)22-8-10-23(11-9-22)16(24)12-15-18-20-21-19-15/h4-7H,8-12H2,1-3H3,(H,18,19,20,21)
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n/an/a 300n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135836
PNG
(US8853215, 59)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1nc[nH]n1
Show InChI InChI=1S/C17H23N5O/c1-17(2,3)13-6-4-5-7-14(13)21-8-10-22(11-9-21)16(23)15-18-12-19-20-15/h4-7,12H,8-11H2,1-3H3,(H,18,19,20)
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n/an/a 15n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135837
PNG
(US8853215, 69)
Show SMILES CC(C)(C)c1cc(Br)ccc1N1CCN(CC1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H23BrN2O3/c1-17(2,3)13-10-12(18)4-5-14(13)19-6-8-20(9-7-19)15(21)11-16(22)23/h4-5,10H,6-9,11H2,1-3H3,(H,22,23)
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n/an/a 30n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135838
PNG
(US8853215, 71)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C1(CC1)C(O)=O
Show InChI InChI=1S/C19H26N2O3/c1-18(2,3)14-6-4-5-7-15(14)20-10-12-21(13-11-20)16(22)19(8-9-19)17(23)24/h4-7H,8-13H2,1-3H3,(H,23,24)
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n/an/a 150n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135839
PNG
(US8853215, 90)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(=O)C1NC(=O)NC1=O
Show InChI InChI=1S/C19H24N4O4/c1-19(2,3)12-6-4-5-7-13(12)22-8-10-23(11-9-22)17(26)15(24)14-16(25)21-18(27)20-14/h4-7,14H,8-11H2,1-3H3,(H2,20,21,25,27)
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n/an/a 34n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM135840
PNG
(US8853215, 110)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(O)CO
Show InChI InChI=1S/C17H26N2O3/c1-17(2,3)13-6-4-5-7-14(13)18-8-10-19(11-9-18)16(22)15(21)12-20/h4-7,15,20-21H,8-12H2,1-3H3
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n/an/a 330n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249457
PNG
(US10072016, Compound 30 | US9434727, 30)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CNCCc23)c1C(F)(F)F
Show InChI InChI=1S/C19H20F4N4O/c20-14-3-1-2-12(16(14)19(21,22)23)11-5-8-27(9-6-11)18(28)17-13-4-7-24-10-15(13)25-26-17/h1-3,11,24H,4-10H2,(H,25,26)
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n/an/a 13.3n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249458
PNG
(US10072016, Compound 32 | US9434727, 32)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CCNCc23)c1C(F)(F)F
Show InChI InChI=1S/C19H20F4N4O/c20-14-3-1-2-12(16(14)19(21,22)23)11-5-8-27(9-6-11)18(28)17-13-10-24-7-4-15(13)25-26-17/h1-3,11,24H,4-10H2,(H,25,26)
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n/an/a 62.5n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249459
PNG
(US10072016, Compound 34 | US9434727, 34)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CNCCc23)c(c1F)C(F)(F)F
Show InChI InChI=1S/C19H19F5N4O/c20-13-2-1-11(15(16(13)21)19(22,23)24)10-4-7-28(8-5-10)18(29)17-12-3-6-25-9-14(12)26-27-17/h1-2,10,25H,3-9H2,(H,26,27)
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n/an/a 20.7n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249460
PNG
(US10072016, Compound 36 | US9434727, 36)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CCNCc23)c(c1F)C(F)(F)F
Show InChI InChI=1S/C19H19F5N4O/c20-13-2-1-11(15(16(13)21)19(22,23)24)10-4-7-28(8-5-10)18(29)17-12-9-25-6-3-14(12)26-27-17/h1-2,10,25H,3-9H2,(H,26,27)
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n/an/a 10.9n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249461
PNG
(US10072016, Compound 38 | US9434727, 38)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CNCc23)c(c1F)C(F)(F)F
Show InChI InChI=1S/C18H17F5N4O/c19-12-2-1-10(14(15(12)20)18(21,22)23)9-3-5-27(6-4-9)17(28)16-11-7-24-8-13(11)25-26-16/h1-2,9,24H,3-8H2,(H,25,26)
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n/an/a 26.9n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249462
PNG
(US10072016, Compound 40 | US9434727, 40)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CNCCc23)c1Cl
Show InChI InChI=1S/C18H20ClFN4O/c19-16-12(2-1-3-14(16)20)11-5-8-24(9-6-11)18(25)17-13-4-7-21-10-15(13)22-23-17/h1-3,11,21H,4-10H2,(H,22,23)
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n/an/a 14.0n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249463
PNG
(US10072016, Compound 42 | US9434727, 42)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CCNCc23)c1Cl
Show InChI InChI=1S/C18H20ClFN4O/c19-16-12(2-1-3-14(16)20)11-5-8-24(9-6-11)18(25)17-13-10-21-7-4-15(13)22-23-17/h1-3,11,21H,4-10H2,(H,22,23)
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n/an/a 424n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249464
PNG
(US10072016, Compound 63 | US9434727, 63)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1C(F)(F)F
Show InChI InChI=1S/C21H22F4N4O2/c1-12(30)29-10-7-15-17(11-29)26-27-19(15)20(31)28-8-5-13(6-9-28)14-3-2-4-16(22)18(14)21(23,24)25/h2-4,13H,5-11H2,1H3,(H,26,27)
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n/an/a 4.46n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249465
PNG
(US10072016, Compound 64 | US9434727, 64)
Show SMILES CS(=O)(=O)N1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cccc(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C20H22F4N4O3S/c1-32(30,31)28-10-7-16-14(11-28)18(26-25-16)19(29)27-8-5-12(6-9-27)13-3-2-4-15(21)17(13)20(22,23)24/h2-4,12H,5-11H2,1H3,(H,25,26)
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n/an/a 5.36n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249466
PNG
(US10072016, Compound 65 | US9434727, 65)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
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n/an/a 4.13n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))
BDBM249466
PNG
(US10072016, Compound 65 | US9434727, 65)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
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n/an/a 9.21n/an/an/an/a7.44



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US9434727 (2016)


BindingDB Entry DOI: 10.7270/Q2F76BGR
More data for this
Ligand-Target Pair
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