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Compile Data Set for Download or QSAR

Found 692 hits Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase alpha-3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111386
PNG
(CHEMBL3604792)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C21H19F2N3O/c22-19-11-15(12-20(23)21(19)27)18-13-25-6-5-17(18)14-1-3-16(4-2-14)26-9-7-24-8-10-26/h1-6,11-13,24,27H,7-10H2
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n/an/an/an/a 140n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50248765
PNG
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)
Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)
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n/an/an/an/a 150n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by western blotting analysis


Nat Chem Biol 3: 156-60 (2007)


Article DOI: 10.1038/nchembio859
BindingDB Entry DOI: 10.7270/Q22B8Z60
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111384
PNG
(CHEMBL3604794)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2
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n/an/an/an/a 210n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111385
PNG
(CHEMBL3604793)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3
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n/an/an/an/a 340n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111377
PNG
(CHEMBL3604885)
Show SMILES Cc1ccc(cc1)-c1nc(N)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C17H13F2N3O/c1-9-2-4-10(5-3-9)15-12(8-21-17(20)22-15)11-6-13(18)16(23)14(19)7-11/h2-8,23H,1H3,(H2,20,21,22)
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n/an/an/an/a 360n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111381
PNG
(CHEMBL3604881)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc(N)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C22H22F2N4O/c1-27-6-8-28(9-7-27)16-4-2-14(3-5-16)17-12-21(25)26-13-18(17)15-10-19(23)22(29)20(24)11-15/h2-5,10-13,29H,6-9H2,1H3,(H2,25,26)
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n/an/an/an/a 440n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111394
PNG
(CHEMBL3604784)
Show SMILES NCCOc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C19H16F2N2O2/c20-17-9-13(10-18(21)19(17)24)16-11-23-6-4-15(16)12-2-1-3-14(8-12)25-7-5-22/h1-4,6,8-11,24H,5,7,22H2
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n/an/an/an/a 490n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111373
PNG
(CHEMBL3604889)
Show SMILES CC(C)CCN1[C@H](C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12
Show InChI InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)/t11-/m1/s1
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111380
PNG
(CHEMBL3604882)
Show SMILES CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C23H24F2N4O/c1-26-22-13-18(19(14-27-22)16-11-20(24)23(30)21(25)12-16)15-3-5-17(6-4-15)29-9-7-28(2)8-10-29/h3-6,11-14,30H,7-10H2,1-2H3,(H,26,27)
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n/an/an/an/a 580n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111374
PNG
(CHEMBL3604888)
Show SMILES CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H27F2N5O/c1-15(2)28-24-27-14-19(17-12-20(25)23(32)21(26)13-17)22(29-24)16-4-6-18(7-5-16)31-10-8-30(3)9-11-31/h4-7,12-15,32H,8-11H2,1-3H3,(H,27,28,29)
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n/an/an/an/a 610n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111378
PNG
(CHEMBL3604884)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc(Nc2ccc(C)cc2)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C29H28F2N4O/c1-19-3-7-22(8-4-19)33-28-17-24(25(18-32-28)21-15-26(30)29(36)27(31)16-21)20-5-9-23(10-6-20)35-13-11-34(2)12-14-35/h3-10,15-18,36H,11-14H2,1-2H3,(H,32,33)
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n/an/an/an/a 690n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111376
PNG
(CHEMBL3604886)
Show SMILES CNc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H15F2N3O/c1-10-3-5-11(6-4-10)16-13(9-22-18(21-2)23-16)12-7-14(19)17(24)15(20)8-12/h3-9,24H,1-2H3,(H,21,22,23)
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n/an/an/an/a 690n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111393
PNG
(CHEMBL3604785)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)-c1cn[nH]c1
Show InChI InChI=1S/C20H13F2N3O/c21-18-7-14(8-19(22)20(18)26)17-11-23-5-4-16(17)13-3-1-2-12(6-13)15-9-24-25-10-15/h1-11,26H,(H,24,25)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111388
PNG
(CHEMBL3604790)
Show SMILES COc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO2/c1-23-13-4-2-11(3-5-13)14-6-7-21-10-15(14)12-8-16(19)18(22)17(20)9-12/h2-10,22H,1H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111391
PNG
(CHEMBL3604787)
Show SMILES CN1CCN(CC1)c1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C22H21F2N3O/c1-26-7-9-27(10-8-26)17-4-2-3-15(11-17)18-5-6-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-6,11-14,28H,7-10H2,1H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111368
PNG
(CHEMBL3604775)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C15H10F2N2O2/c16-12-5-9(6-13(17)15(12)21)14-11(7-18-19-14)8-1-3-10(20)4-2-8/h1-7,20-21H,(H,18,19)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111375
PNG
(CHEMBL3604887)
Show SMILES CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C20H19F2N3O/c1-11(2)24-20-23-10-15(14-8-16(21)19(26)17(22)9-14)18(25-20)13-6-4-12(3)5-7-13/h4-11,26H,1-3H3,(H,23,24,25)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111389
PNG
(CHEMBL3604789)
Show SMILES Cc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO/c1-11-2-4-12(5-3-11)14-6-7-21-10-15(14)13-8-16(19)18(22)17(20)9-13/h2-10,22H,1H3
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n/an/an/an/a 1.60E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111387
PNG
(CHEMBL3604791)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C19H14F2N2O2/c1-22-19(25)12-4-2-11(3-5-12)14-6-7-23-10-15(14)13-8-16(20)18(24)17(21)9-13/h2-10,24H,1H3,(H,22,25)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111364
PNG
(CHEMBL3604779)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1C1CCOCC1
Show InChI InChI=1S/C16H15F2NO2/c17-14-7-11(8-15(18)16(14)20)13-9-19-4-1-12(13)10-2-5-21-6-3-10/h1,4,7-10,20H,2-3,5-6H2
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n/an/an/an/a 2.20E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111392
PNG
(CHEMBL3604786)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-5-4-17(18)14-2-1-3-16(10-14)25-6-8-27-9-7-25/h1-5,10-13,26H,6-9H2
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n/an/an/an/a 2.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111379
PNG
(CHEMBL3604883)
Show SMILES CC(C)CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C26H30F2N4O/c1-17(2)15-29-25-14-21(22(16-30-25)19-12-23(27)26(33)24(28)13-19)18-4-6-20(7-5-18)32-10-8-31(3)9-11-32/h4-7,12-14,16-17,33H,8-11,15H2,1-3H3,(H,29,30)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111372
PNG
(CHEMBL3604771)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1ccc(O)cc1
Show InChI InChI=1S/C15H12N2O2/c18-12-5-1-10(2-6-12)14-9-16-17-15(14)11-3-7-13(19)8-4-11/h1-9,18-19H,(H,16,17)
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n/an/an/an/a 2.80E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111369
PNG
(CHEMBL3604774)
Show SMILES Nc1n[nH]c(c1-c1ccccc1)-c1ccc(O)cc1
Show InChI InChI=1S/C15H13N3O/c16-15-13(10-4-2-1-3-5-10)14(17-18-15)11-6-8-12(19)9-7-11/h1-9,19H,(H3,16,17,18)
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n/an/an/an/a 3.20E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111361
PNG
(CHEMBL3604782)
Show SMILES Cc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO/c1-11-3-2-4-12(7-11)14-5-6-21-10-15(14)13-8-16(19)18(22)17(20)9-13/h2-10,22H,1H3
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n/an/an/an/a 4.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111365
PNG
(CHEMBL3604778)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccccc1
Show InChI InChI=1S/C17H11F2NO/c18-15-8-12(9-16(19)17(15)21)14-10-20-7-6-13(14)11-4-2-1-3-5-11/h1-10,21H
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n/an/an/an/a 4.20E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111383
PNG
(CHEMBL3604795)
Show SMILES COc1ccc(cn1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C17H12F2N2O2/c1-23-16-3-2-10(8-21-16)12-4-5-20-9-13(12)11-6-14(18)17(22)15(19)7-11/h2-9,22H,1H3
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n/an/an/an/a 5.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111395
PNG
(CHEMBL3604783)
Show SMILES COc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO2/c1-23-13-4-2-3-11(7-13)14-5-6-21-10-15(14)12-8-16(19)18(22)17(20)9-12/h2-10,22H,1H3
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n/an/an/an/a 5.60E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111366
PNG
(CHEMBL3604777)
Show SMILES Oc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C17H11F2NO2/c18-15-7-11(8-16(19)17(15)22)14-9-20-6-5-13(14)10-1-3-12(21)4-2-10/h1-9,21-22H
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n/an/an/an/a 6.40E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111367
PNG
(CHEMBL3604776)
Show SMILES Oc1ccc(cc1)-c1ccncc1-c1ccc(O)cc1
Show InChI InChI=1S/C17H13NO2/c19-14-5-1-12(2-6-14)16-9-10-18-11-17(16)13-3-7-15(20)8-4-13/h1-11,19-20H
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n/an/an/an/a 9.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50324684
PNG
(3-(1-(4-amino-6-(2-fluoroacetyl)-5-p-tolyl-7H-pyrr...)
Show SMILES C[C+]1C=C(C)C2=Cc3ccc(CCC(=O)NCCCCCC(=O)NCCCCNC(=O)OCCCn4c(C(=O)CF)c(-c5ccc(C)cc5)c5c(N)ncnc45)n3[B-](F)(F)C12
Show InChI InChI=1S/C44H54BF3N8O5/c1-28-11-13-31(14-12-28)38-39-42(49)53-27-54-43(39)55(41(38)35(57)26-46)22-9-23-61-44(60)52-21-8-7-20-50-36(58)10-5-4-6-19-51-37(59)18-17-32-15-16-33-25-34-29(2)24-30(3)40(34)45(47,48)56(32)33/h11-16,24-25,27,40H,4-10,17-23,26H2,1-3H3,(H,50,58)(H,51,59)(H,52,60)(H2,49,53,54)
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n/an/an/an/a 1.00E+4n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by western blotting analysis


Nat Chem Biol 3: 156-60 (2007)


Article DOI: 10.1038/nchembio859
BindingDB Entry DOI: 10.7270/Q22B8Z60
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111390
PNG
(CHEMBL3604788)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10F3NO/c18-12-3-1-10(2-4-12)13-5-6-21-9-14(13)11-7-15(19)17(22)16(20)8-11/h1-9,22H
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n/an/an/an/a 1.04E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111370
PNG
(CHEMBL3604773)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-11(7-9-13)14-10-16-17-15(14)12-4-2-1-3-5-12/h1-10,18H,(H,16,17)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111363
PNG
(CHEMBL3604780)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1C1CCNCC1
Show InChI InChI=1S/C16H16F2N2O/c17-14-7-11(8-15(18)16(14)21)13-9-20-6-3-12(13)10-1-4-19-5-2-10/h3,6-10,19,21H,1-2,4-5H2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111362
PNG
(CHEMBL3604781)
Show SMILES CC(C)c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C14H13F2NO/c1-8(2)10-3-4-17-7-11(10)9-5-12(15)14(18)13(16)6-9/h3-8,18H,1-2H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111371
PNG
(CHEMBL3604772)
Show SMILES Oc1ccc(cc1)-c1[nH]ncc1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-12(7-9-13)15-14(10-16-17-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111382
PNG
(CHEMBL3604796)
Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10Cl2FNO/c18-15-7-11(8-16(19)17(15)22)14-9-21-6-5-13(14)10-1-3-12(20)4-2-10/h1-9,22H
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant RSK2 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50205468
PNG
((Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H...)
Show SMILES NC1=NC(=O)C(S1)=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C13H9N3OS/c14-13-16-12(17)11(18-13)7-8-3-4-10-9(6-8)2-1-5-15-10/h1-7H,(H2,14,16,17)
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of PKAP1


Bioorg Med Chem Lett 17: 2134-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.081
BindingDB Entry DOI: 10.7270/Q2BV7G9T
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50205472
PNG
((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Show SMILES O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of PKAP1


Bioorg Med Chem Lett 17: 2134-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.081
BindingDB Entry DOI: 10.7270/Q2BV7G9T
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50205477
PNG
((Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinol...)
Show SMILES O=C1N=C(N[C@@H]2C[C@H]2c2ccccc2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C22H17N3OS/c26-21-20(12-14-8-9-18-16(11-14)7-4-10-23-18)27-22(25-21)24-19-13-17(19)15-5-2-1-3-6-15/h1-12,17,19H,13H2,(H,24,25,26)/t17-,19+/m0/s1
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of PKAP1


Bioorg Med Chem Lett 17: 2134-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.081
BindingDB Entry DOI: 10.7270/Q2BV7G9T
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>7.37E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RSK2


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM31096
PNG
(CHEMBL290084 | Staurosporine | cid_451705)
Show SMILES CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1
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6.90E+4n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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5.80E+5n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM31094
PNG
(PKC-412 | cid_24202429)
Show SMILES CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1
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7.40E+5n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
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2.10E+6n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM17055
PNG
((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Show SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1
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3.60E+6n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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5.60E+6n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM13534
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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6.40E+6n/an/an/an/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q21N7ZHF
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (human))
BDBM50431809
PNG
(CHEMBL2347062)
Show SMILES CCc1cccc2C(C(=O)Nc12)=C1SC(=S)NC1=O
Show InChI InChI=1S/C13H10N2O2S2/c1-2-6-4-3-5-7-8(11(16)14-9(6)7)10-12(17)15-13(18)19-10/h3-5H,2H2,1H3,(H,14,16)(H,15,17,18)
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n/an/a 1.70E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of RSK2 (unknown origin) using AKRRRLSSLRA as substrate after 60 mins by fluorescence assay


Bioorg Med Chem 21: 1724-34 (2013)


Article DOI: 10.1016/j.bmc.2013.01.047
BindingDB Entry DOI: 10.7270/Q2GQ704N
More data for this
Ligand-Target Pair
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