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Compile Data Set for Download or QSAR

Found 121 hits Enz. Inhib. hit(s) with Target = 'Secreted frizzled-related protein 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50265500
PNG
((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308692
PNG
(CHEMBL606033 | N-(1-{[6-(Dimethylamino)pyridin-3-y...)
Show SMILES CN(C)c1ccc(cn1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H27F3N4O5S2/c1-32(2)24-11-8-18(17-30-24)25(34)33-14-12-19(13-15-33)31-40(37,38)23-16-21(9-10-22(23)26(27,28)29)39(35,36)20-6-4-3-5-7-20/h3-11,16-17,19,31H,12-15H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308698
PNG
(CHEMBL600050 | tert-Butyl(3R)-3-{[4-({[5-(phenylsu...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-14-11-19(18-34)25(35)33-15-12-20(13-16-33)32-43(39,40)24-17-22(9-10-23(24)28(29,30)31)42(37,38)21-7-5-4-6-8-21/h4-10,17,19-20,32H,11-16,18H2,1-3H3/t19-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308711
PNG
(4-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phe...)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H23F3N2O8S3/c26-25(27,28)22-11-10-21(39(33,34)19-4-2-1-3-5-19)16-23(22)40(35,36)29-18-12-14-30(15-13-18)41(37,38)20-8-6-17(7-9-20)24(31)32/h1-11,16,18,29H,12-15H2,(H,31,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308689
PNG
(CHEMBL589067 | N-(1-Isonicotinoylpiperidin-4-yl)-5...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1cccnc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H22F3N3O5S2/c25-24(26,27)21-9-8-20(36(32,33)19-6-2-1-3-7-19)15-22(21)37(34,35)29-18-10-13-30(14-11-18)23(31)17-5-4-12-28-16-17/h1-9,12,15-16,18,29H,10-11,13-14H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308694
PNG
(CHEMBL590478 | N-{1-[(6-Morpholin-4-ylpyridin-3-yl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(nc1)N1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H29F3N4O6S2/c29-28(30,31)24-8-7-23(42(37,38)22-4-2-1-3-5-22)18-25(24)43(39,40)33-21-10-12-35(13-11-21)27(36)20-6-9-26(32-19-20)34-14-16-41-17-15-34/h1-9,18-19,21,33H,10-17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308691
PNG
(5-(Phenylsulfonyl)-2-(trifluoromethyl)-N-(1-{[6-(t...)
Show SMILES FC(F)(F)c1ccc(cn1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H21F6N3O5S2/c26-24(27,28)20-8-7-19(40(36,37)18-4-2-1-3-5-18)14-21(20)41(38,39)33-17-10-12-34(13-11-17)23(35)16-6-9-22(32-15-16)25(29,30)31/h1-9,14-15,17,33H,10-13H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308690
PNG
(CHEMBL605196 | N-{1-[(6-Chloropyridin-3-yl)carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(Cl)nc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H21ClF3N3O5S2/c25-22-9-6-16(15-29-22)23(32)31-12-10-17(11-13-31)30-38(35,36)21-14-19(7-8-20(21)24(26,27)28)37(33,34)18-4-2-1-3-5-18/h1-9,14-15,17,30H,10-13H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308699
PNG
(5-(Phenylsulfonyl)-N-[1-(piperidin-4-ylcarbonyl)pi...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)C1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H28F3N3O5S2/c25-24(26,27)21-7-6-20(36(32,33)19-4-2-1-3-5-19)16-22(21)37(34,35)29-18-10-14-30(15-11-18)23(31)17-8-12-28-13-9-17/h1-7,16-18,28-29H,8-15H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308697
PNG
(CHEMBL600049 | tert-Butyl(3S)-3-{[4-({[5-(phenylsu...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@H](C1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-14-11-19(18-34)25(35)33-15-12-20(13-16-33)32-43(39,40)24-17-22(9-10-23(24)28(29,30)31)42(37,38)21-7-5-4-6-8-21/h4-10,17,19-20,32H,11-16,18H2,1-3H3/t19-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308713
PNG
(CHEMBL592455 | N-{1-[(3-Cyanophenyl)sulfonyl]piper...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)S(=O)(=O)c1cccc(c1)C#N)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H22F3N3O6S3/c26-25(27,28)23-10-9-21(38(32,33)20-6-2-1-3-7-20)16-24(23)39(34,35)30-19-11-13-31(14-12-19)40(36,37)22-8-4-5-18(15-22)17-29/h1-10,15-16,19,30H,11-14H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308686
PNG
(CHEMBL589567 | N-{1-[4-(Dimethylamino)benzoyl]pipe...)
Show SMILES CN(C)c1ccc(cc1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H28F3N3O5S2/c1-32(2)21-10-8-19(9-11-21)26(34)33-16-14-20(15-17-33)31-40(37,38)25-18-23(12-13-24(25)27(28,29)30)39(35,36)22-6-4-3-5-7-22/h3-13,18,20,31H,14-17H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308710
PNG
(3-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phe...)
Show SMILES OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H23F3N2O8S3/c26-25(27,28)22-10-9-20(39(33,34)19-6-2-1-3-7-19)16-23(22)40(35,36)29-18-11-13-30(14-12-18)41(37,38)21-8-4-5-17(15-21)24(31)32/h1-10,15-16,18,29H,11-14H2,(H,31,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50265501
PNG
((R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308700
PNG
(5-(Phenylsulfonyl)-N-[1-(piperidin-4-ylacetyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CC1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H30F3N3O5S2/c26-25(27,28)22-7-6-21(37(33,34)20-4-2-1-3-5-20)17-23(22)38(35,36)30-19-10-14-31(15-11-19)24(32)16-18-8-12-29-13-9-18/h1-7,17-19,29-30H,8-16H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308716
PNG
(5-(Phenylsulfonyl)-N-[1-(phenylsulfonyl)piperidin-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H23F3N2O6S3/c25-24(26,27)22-12-11-21(36(30,31)19-7-3-1-4-8-19)17-23(22)37(32,33)28-18-13-15-29(16-14-18)38(34,35)20-9-5-2-6-10-20/h1-12,17-18,28H,13-16H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308693
PNG
(5-(Phenylsulfonyl)-N-{1-[(6-pyrrolidin-1-ylpyridin...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(nc1)N1CCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H29F3N4O5S2/c29-28(30,31)24-10-9-23(41(37,38)22-6-2-1-3-7-22)18-25(24)42(39,40)33-21-12-16-35(17-13-21)27(36)20-8-11-26(32-19-20)34-14-4-5-15-34/h1-3,6-11,18-19,21,33H,4-5,12-17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308688
PNG
(5-(Phenylsulfonyl)-N-[1-(pyridin-3-ylcarbonyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccccn1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H22F3N3O5S2/c25-24(26,27)20-10-9-19(36(32,33)18-6-2-1-3-7-18)16-22(20)37(34,35)29-17-11-14-30(15-12-17)23(31)21-8-4-5-13-28-21/h1-10,13,16-17,29H,11-12,14-15H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308715
PNG
(4-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phen...)
Show SMILES OC(=O)c1ccc(cc1)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H23F3N2O6S2/c26-25(27,28)22-11-10-21(37(33,34)20-4-2-1-3-5-20)16-23(22)38(35,36)29-18-12-14-30(15-13-18)19-8-6-17(7-9-19)24(31)32/h1-11,16,18,29H,12-15H2,(H,31,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308681
PNG
(CHEMBL589088 | N-(1-Benzoylpiperidin-4-yl)-5-(phen...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H23F3N2O5S2/c26-25(27,28)22-12-11-21(36(32,33)20-9-5-2-6-10-20)17-23(22)37(34,35)29-19-13-15-30(16-14-19)24(31)18-7-3-1-4-8-18/h1-12,17,19,29H,13-16H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308703
PNG
(2-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phen...)
Show SMILES NC(=O)CN1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H22F3N3O5S2/c21-20(22,23)17-7-6-16(32(28,29)15-4-2-1-3-5-15)12-18(17)33(30,31)25-14-8-10-26(11-9-14)13-19(24)27/h1-7,12,14,25H,8-11,13H2,(H2,24,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308714
PNG
(3-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phen...)
Show SMILES OC(=O)c1cccc(c1)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H23F3N2O6S2/c26-25(27,28)22-10-9-21(37(33,34)20-7-2-1-3-8-20)16-23(22)38(35,36)29-18-11-13-30(14-12-18)19-6-4-5-17(15-19)24(31)32/h1-10,15-16,18,29H,11-14H2,(H,31,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50265503
PNG
((S)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308702
PNG
(5-(Phenylsulfonyl)-N-{1-[(3R)-pyrrolidin-3-ylcarbo...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCNC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)20-7-6-19(35(31,32)18-4-2-1-3-5-18)14-21(20)36(33,34)28-17-9-12-29(13-10-17)22(30)16-8-11-27-15-16/h1-7,14,16-17,27-28H,8-13,15H2/t16-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308696
PNG
(CHEMBL590312 | tert-Butyl 4-{2-oxo-2-[4-({[5-(phen...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC(=O)N2CCC(CC2)NS(=O)(=O)c2cc(ccc2C(F)(F)F)S(=O)(=O)c2ccccc2)CC1
Show InChI InChI=1S/C30H38F3N3O7S2/c1-29(2,3)43-28(38)36-15-11-21(12-16-36)19-27(37)35-17-13-22(14-18-35)34-45(41,42)26-20-24(9-10-25(26)30(31,32)33)44(39,40)23-7-5-4-6-8-23/h4-10,20-22,34H,11-19H2,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308706
PNG
(4-Oxo-4-[4-({[5-(phenylsulfonyl)-2-(trifluoromethy...)
Show SMILES OC(=O)CCC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H23F3N2O7S2/c23-22(24,25)18-7-6-17(35(31,32)16-4-2-1-3-5-16)14-19(18)36(33,34)26-15-10-12-27(13-11-15)20(28)8-9-21(29)30/h1-7,14-15,26H,8-13H2,(H,29,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308695
PNG
(CHEMBL590304 | tert-Butyl 4-{[4-({[5-(phenylsulfon...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C29H36F3N3O7S2/c1-28(2,3)42-27(37)35-15-11-20(12-16-35)26(36)34-17-13-21(14-18-34)33-44(40,41)25-19-23(9-10-24(25)29(30,31)32)43(38,39)22-7-5-4-6-8-22/h4-10,19-21,33H,11-18H2,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308704
PNG
(CHEMBL591483 | [4-({[5-(Phenylsulfonyl)-2-(trifluo...)
Show SMILES OC(=O)CN1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H21F3N2O6S2/c21-20(22,23)17-7-6-16(32(28,29)15-4-2-1-3-5-15)12-18(17)33(30,31)24-14-8-10-25(11-9-14)13-19(26)27/h1-7,12,14,24H,8-11,13H2,(H,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308707
PNG
(5-Oxo-5-[4-({[5-(phenylsulfonyl)-2-(trifluoromethy...)
Show SMILES OC(=O)CCCC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H25F3N2O7S2/c24-23(25,26)19-10-9-18(36(32,33)17-5-2-1-3-6-17)15-20(19)37(34,35)27-16-11-13-28(14-12-16)21(29)7-4-8-22(30)31/h1-3,5-6,9-10,15-16,27H,4,7-8,11-14H2,(H,30,31)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308687
PNG
(5-(Phenylsulfonyl)-N-[1-(pyridin-2-ylcarbonyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccncc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H22F3N3O5S2/c25-24(26,27)21-7-6-20(36(32,33)19-4-2-1-3-5-19)16-22(21)37(34,35)29-18-10-14-30(15-11-18)23(31)17-8-12-28-13-9-17/h1-9,12-13,16,18,29H,10-11,14-15H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308709
PNG
(CHEMBL602239 | N-[1-(2-Hydroxy-2-methylpropyl)pipe...)
Show SMILES CC(C)(O)CCN1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H29F3N2O5S2/c1-22(2,29)12-15-28-13-10-17(11-14-28)27-35(32,33)21-16-19(8-9-20(21)23(24,25)26)34(30,31)18-6-4-3-5-7-18/h3-9,16-17,27,29H,10-15H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308701
PNG
(5-(Phenylsulfonyl)-N-{1-[(3S)-pyrrolidin-3-ylcarbo...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@H]1CCNC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)20-7-6-19(35(31,32)18-4-2-1-3-5-18)14-21(20)36(33,34)28-17-9-12-29(13-10-17)22(30)16-8-11-27-15-16/h1-7,14,16-17,27-28H,8-13,15H2/t16-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50265504
PNG
((R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@H]1CCCN1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308708
PNG
(CHEMBL592692 | N-[1-(2-Hydroxyethyl)piperidin-4-yl...)
Show SMILES OCCCN1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H25F3N2O5S2/c22-21(23,24)19-8-7-18(32(28,29)17-5-2-1-3-6-17)15-20(19)33(30,31)25-16-9-12-26(13-10-16)11-4-14-27/h1-3,5-8,15-16,25,27H,4,9-14H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308683
PNG
(CHEMBL589332 | N-[1-(3-Chlorobenzoyl)piperidin-4-y...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H22ClF3N2O5S2/c26-18-6-4-5-17(15-18)24(32)31-13-11-19(12-14-31)30-38(35,36)23-16-21(9-10-22(23)25(27,28)29)37(33,34)20-7-2-1-3-8-20/h1-10,15-16,19,30H,11-14H2
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n/an/an/an/a 870n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308685
PNG
(5-(Phenylsulfonyl)-2-(trifluoromethyl)-N-{1-[4-(tr...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H22F6N2O5S2/c27-25(28,29)18-8-6-17(7-9-18)24(35)34-14-12-19(13-15-34)33-41(38,39)23-16-21(10-11-22(23)26(30,31)32)40(36,37)20-4-2-1-3-5-20/h1-11,16,19,33H,12-15H2
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n/an/an/an/a 970n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308705
PNG
(3-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phen...)
Show SMILES OC(=O)CCN1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H23F3N2O6S2/c22-21(23,24)18-7-6-17(33(29,30)16-4-2-1-3-5-16)14-19(18)34(31,32)25-15-8-11-26(12-9-15)13-10-20(27)28/h1-7,14-15,25H,8-13H2,(H,27,28)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308712
PNG
(5-(Phenylsulfonyl)-N-(1-{[3-(2H-tetrazol-5-yl)phen...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1nnn[nH]1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H23F3N6O6S3/c26-25(27,28)22-10-9-20(41(35,36)19-6-2-1-3-7-19)16-23(22)42(37,38)31-18-11-13-34(14-12-18)43(39,40)21-8-4-5-17(15-21)24-29-32-33-30-24/h1-10,15-16,18,31H,11-14H2,(H,29,30,32,33)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50246616
PNG
(CHEMBL473916 | N-[3-(Dimethylamino)propyl]-2-ethyl...)
Show SMILES CCc1ccc(cc1S(=O)(=O)NCCCN(C)C)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H26N2O4S2/c1-4-16-11-12-18(26(22,23)17-9-6-5-7-10-17)15-19(16)27(24,25)20-13-8-14-21(2)3/h5-7,9-12,15,20H,4,8,13-14H2,1-3H3
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n/an/an/an/a 1.27E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assay


J Med Chem 51: 7670-2 (2008)


Article DOI: 10.1021/jm801069w
BindingDB Entry DOI: 10.7270/Q2N58M6D
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308684
PNG
(CHEMBL590541 | N-[1-(4-Chlorobenzoyl)piperidin-4-y...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H22ClF3N2O5S2/c26-18-8-6-17(7-9-18)24(32)31-14-12-19(13-15-31)30-38(35,36)23-16-21(10-11-22(23)25(27,28)29)37(33,34)20-4-2-1-3-5-20/h1-11,16,19,30H,12-15H2
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n/an/an/an/a 1.80E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50308682
PNG
(CHEMBL589331 | N-[1-(2-Chlorobenzoyl)piperidin-4-y...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccccc1Cl)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H22ClF3N2O5S2/c26-22-9-5-4-8-20(22)24(32)31-14-12-17(13-15-31)30-38(35,36)23-16-19(10-11-21(23)25(27,28)29)37(33,34)18-6-2-1-3-7-18/h1-11,16-17,30H,12-15H2
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n/an/an/an/a 1.90E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...


Bioorg Med Chem 18: 190-201 (2010)


Article DOI: 10.1016/j.bmc.2009.11.002
BindingDB Entry DOI: 10.7270/Q2PZ58Z7
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50247135
PNG
(2-methyl-N-phenethyl-5-(phenylsulfonyl)benzenesulf...)
Show SMILES Cc1ccc(cc1S(=O)(=O)NCCc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H21NO4S2/c1-17-12-13-20(27(23,24)19-10-6-3-7-11-19)16-21(17)28(25,26)22-15-14-18-8-4-2-5-9-18/h2-13,16,22H,14-15H2,1H3
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n/an/an/an/a 3.88E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assay


J Med Chem 51: 7670-2 (2008)


Article DOI: 10.1021/jm801069w
BindingDB Entry DOI: 10.7270/Q2N58M6D
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50246651
PNG
(CHEMBL474926 | N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-...)
Show SMILES CCc1ccc(cc1S(=O)(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H27NO6S2/c1-4-19-11-12-21(32(26,27)20-8-6-5-7-9-20)17-24(19)33(28,29)25-15-14-18-10-13-22(30-2)23(16-18)31-3/h5-13,16-17,25H,4,14-15H2,1-3H3
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n/an/an/an/a 6.97E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assay


J Med Chem 51: 7670-2 (2008)


Article DOI: 10.1021/jm801069w
BindingDB Entry DOI: 10.7270/Q2N58M6D
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50302906
PNG
(CHEMBL569227 | methyl 2-(2-(2-imino-4-oxothiazolid...)
Show SMILES COC(=O)c1c(C)c(C)sc1NC(=O)Cc1sc(N)nc1O
Show InChI InChI=1S/C13H15N3O4S2/c1-5-6(2)21-11(9(5)12(19)20-3)15-8(17)4-7-10(18)16-13(14)22-7/h18H,4H2,1-3H3,(H2,14,16)(H,15,17)
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n/an/an/an/a 7.20E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human SFRP1 transfected in human U20S cells by TCF-luciferase reporter gene assay


Bioorg Med Chem Lett 19: 6337-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.085
BindingDB Entry DOI: 10.7270/Q2930T7H
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50246617
PNG
(2-Ethyl-5-(phenylsulfonyl)-N-(3-pyrrolidin-1-ylpro...)
Show SMILES CCc1ccc(cc1S(=O)(=O)NCCCN1CCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H28N2O4S2/c1-2-18-11-12-20(28(24,25)19-9-4-3-5-10-19)17-21(18)29(26,27)22-13-8-16-23-14-6-7-15-23/h3-5,9-12,17,22H,2,6-8,13-16H2,1H3
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n/an/an/an/a 9.00E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assay


J Med Chem 51: 7670-2 (2008)


Article DOI: 10.1021/jm801069w
BindingDB Entry DOI: 10.7270/Q2N58M6D
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50017346
PNG
(CHEMBL3288258)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NC(C)=O
Show InChI InChI=1S/C47H75N3O52S6.9Na/c1-5-6-7-8-85-42-18(48-12(2)51)21(54)28(15(89-42)9-86-103(67,68)69)93-46-35(101-107(79,80)81)26(59)31(37(98-46)40(63)64)96-44-20(50-14(4)53)23(56)30(17(91-44)11-88-105(73,74)75)94-47-36(102-108(82,83)84)27(60)32(38(99-47)41(65)66)95-43-19(49-13(3)52)22(55)29(16(90-43)10-87-104(70,71)72)92-45-34(100-106(76,77)78)25(58)24(57)33(97-45)39(61)62;;;;;;;;;/h15-38,42-47,54-60H,5-11H2,1-4H3,(H,48,51)(H,49,52)(H,50,53)(H,61,62)(H,63,64)(H,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75)(H,76,77,78)(H,79,80,81)(H,82,83,84);;;;;;;;;/q;9*+1/p-9/t15-,16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,42+,43-,44-,45-,46-,47-;;;;;;;;;/m1........./s1
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n/an/an/a 2.50E+8n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant sFRP1 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)


Article DOI: 10.1021/jm4016069
BindingDB Entry DOI: 10.7270/Q2ZG6TSN
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50017347
PNG
(CHEMBL3288259)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].NCCCCCO[C@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
Show InChI InChI=1S/C41H70N4O49S6.9Na/c42-4-2-1-3-5-80-36-12(43-95(62,63)64)15(49)22(9(6-46)81-36)85-40-29(93-99(74,75)76)20(54)25(31(90-40)34(58)59)88-38-14(45-97(68,69)70)17(51)24(11(8-48)83-38)86-41-30(94-100(77,78)79)21(55)26(32(91-41)35(60)61)87-37-13(44-96(65,66)67)16(50)23(10(7-47)82-37)84-39-28(92-98(71,72)73)19(53)18(52)27(89-39)33(56)57;;;;;;;;;/h9-32,36-41,43-55H,1-8,42H2,(H,56,57)(H,58,59)(H,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79);;;;;;;;;/q;9*+1/p-9/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18+,19+,20+,21+,22-,23-,24-,25+,26+,27-,28-,29-,30-,31-,32-,36+,37-,38-,39-,40-,41-;;;;;;;;;/m1........./s1
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n/an/an/a 9.00E+3n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant sFRP1 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)


Article DOI: 10.1021/jm4016069
BindingDB Entry DOI: 10.7270/Q2ZG6TSN
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50017345
PNG
(CHEMBL3288260)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](O)[C@H]1NC(C)=O
Show InChI InChI=1S/C45H73N3O51S6.9Na/c1-4-5-6-7-83-40-16(46-11(2)49)19(51)27(13(87-40)8-84-101(68,69)70)90-43-25(57)24(56)30(35(96-43)38(61)62)93-42-18(48-100(65,66)67)21(53)29(15(89-42)10-86-103(74,75)76)92-45-34(99-105(80,81)82)26(58)31(36(97-45)39(63)64)94-41-17(47-12(3)50)20(52)28(14(88-41)9-85-102(71,72)73)91-44-33(98-104(77,78)79)23(55)22(54)32(95-44)37(59)60;;;;;;;;;/h13-36,40-45,48,51-58H,4-10H2,1-3H3,(H,46,49)(H,47,50)(H,59,60)(H,61,62)(H,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82);;;;;;;;;/q;9*+1/p-9/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22+,23+,24-,25-,26+,27-,28-,29-,30+,31+,32-,33-,34-,35-,36-,40+,41-,42-,43-,44-,45-;;;;;;;;;/m1........./s1
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n/an/an/a 2.50E+8n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant sFRP1 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)


Article DOI: 10.1021/jm4016069
BindingDB Entry DOI: 10.7270/Q2ZG6TSN
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50247135
PNG
(2-methyl-N-phenethyl-5-(phenylsulfonyl)benzenesulf...)
Show SMILES Cc1ccc(cc1S(=O)(=O)NCCc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H21NO4S2/c1-17-12-13-20(27(23,24)19-10-6-3-7-11-19)16-21(17)28(25,26)22-15-14-18-8-4-2-5-9-18/h2-13,16,22H,14-15H2,1H3
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n/an/an/a 350n/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to human sFRP1 by flurescence spectroscopy


J Med Chem 51: 7670-2 (2008)


Article DOI: 10.1021/jm801069w
BindingDB Entry DOI: 10.7270/Q2N58M6D
More data for this
Ligand-Target Pair
Secreted frizzled-related protein 1


(Homo sapiens)
BDBM50265467
PNG
(5-(Phenylsulfonyl)-N-piperidin-4-yl-2-(trifluorome...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
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UniChem

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n/an/a 500n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to human purified SARP2 by fluorescent polarization assay


J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
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