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Compile Data Set for Download or QSAR

Found 1690 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase TBK1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379339
PNG
(CHEMBL2011940)
Show SMILES Nc1cccc(c1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CCC3)c2[nH]1
Show InChI InChI=1S/C20H23BrN6O/c21-15-11-25-19-17(26-18(27-19)13-6-2-7-14(22)10-13)16(15)23-8-3-9-24-20(28)12-4-1-5-12/h2,6-7,10-12H,1,3-5,8-9,22H2,(H,24,28)(H2,23,25,26,27)
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n/an/an/an/a 4n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379357
PNG
(CHEMBL2011933)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CCC3)c2[nH]1
Show InChI InChI=1S/C21H24BrN5O2/c1-29-15-8-6-13(7-9-15)19-26-18-17(16(22)12-25-20(18)27-19)23-10-3-11-24-21(28)14-4-2-5-14/h6-9,12,14H,2-5,10-11H2,1H3,(H,24,28)(H2,23,25,26,27)
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n/an/an/an/a 6n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379358
PNG
(CHEMBL2011934)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)c2[nH]1
Show InChI InChI=1S/C22H26BrN5O2/c1-28(22(29)15-5-3-6-15)12-4-11-24-18-17(23)13-25-21-19(18)26-20(27-21)14-7-9-16(30-2)10-8-14/h7-10,13,15H,3-6,11-12H2,1-2H3,(H2,24,25,26,27)
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n/an/an/an/a 6n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379337
PNG
(CHEMBL2011936)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CCCC3)c2[nH]1
Show InChI InChI=1S/C22H26BrN5O2/c1-30-16-9-7-14(8-10-16)20-27-19-18(17(23)13-26-21(19)28-20)24-11-4-12-25-22(29)15-5-2-3-6-15/h7-10,13,15H,2-6,11-12H2,1H3,(H,25,29)(H2,24,26,27,28)
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n/an/an/an/a 8n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379354
PNG
(CHEMBL2011930)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)(C)C)c2[nH]1
Show InChI InChI=1S/C21H26BrN5O2/c1-21(2,3)20(28)24-11-5-10-23-16-15(22)12-25-19-17(16)26-18(27-19)13-6-8-14(29-4)9-7-13/h6-9,12H,5,10-11H2,1-4H3,(H,24,28)(H2,23,25,26,27)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379363
PNG
(CHEMBL2011941)
Show SMILES Brc1cnc2nc([nH]c2c1NCCCNC(=O)C1CCC1)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C27H35BrN6O2/c28-22-18-31-26-24(23(22)29-12-5-13-30-27(35)20-6-4-7-20)32-25(33-26)19-8-10-21(11-9-19)36-17-16-34-14-2-1-3-15-34/h8-11,18,20H,1-7,12-17H2,(H,30,35)(H2,29,31,32,33)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379353
PNG
(CHEMBL2011929)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C(C)C)c2[nH]1
Show InChI InChI=1S/C20H24BrN5O2/c1-12(2)20(27)23-10-4-9-22-16-15(21)11-24-19-17(16)25-18(26-19)13-5-7-14(28-3)8-6-13/h5-8,11-12H,4,9-10H2,1-3H3,(H,23,27)(H2,22,24,25,26)
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n/an/an/an/a 14n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379367
PNG
(CHEMBL2011945)
Show SMILES COc1ccc(F)cc1-c1nc2ncc(Br)c(NCCCNC(=O)C3CCC3)c2[nH]1
Show InChI InChI=1S/C21H23BrFN5O2/c1-30-16-7-6-13(23)10-14(16)19-27-18-17(15(22)11-26-20(18)28-19)24-8-3-9-25-21(29)12-4-2-5-12/h6-7,10-12H,2-5,8-9H2,1H3,(H,25,29)(H2,24,26,27,28)
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n/an/an/an/a 17n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379356
PNG
(CHEMBL2011932)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3(CN)CC3)c2[nH]1
Show InChI InChI=1S/C21H25BrN6O2/c1-30-14-5-3-13(4-6-14)18-27-17-16(15(22)11-26-19(17)28-18)24-9-2-10-25-20(29)21(12-23)7-8-21/h3-6,11H,2,7-10,12,23H2,1H3,(H,25,29)(H2,24,26,27,28)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379355
PNG
(CHEMBL2011931)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CC3)c2[nH]1
Show InChI InChI=1S/C20H22BrN5O2/c1-28-14-7-5-12(6-8-14)18-25-17-16(15(21)11-24-19(17)26-18)22-9-2-10-23-20(27)13-3-4-13/h5-8,11,13H,2-4,9-10H2,1H3,(H,23,27)(H2,22,24,25,26)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379362
PNG
(CHEMBL2011939)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)c3cccs3)c2[nH]1
Show InChI InChI=1S/C21H20BrN5O2S/c1-29-14-7-5-13(6-8-14)19-26-18-17(15(22)12-25-20(18)27-19)23-9-3-10-24-21(28)16-4-2-11-30-16/h2,4-8,11-12H,3,9-10H2,1H3,(H,24,28)(H2,23,25,26,27)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379368
PNG
(CHEMBL2010815)
Show SMILES COc1cc(F)ccc1-c1nc2ncc(Br)c(NCCCNC(=O)C3CCC3)c2[nH]1
Show InChI InChI=1S/C21H23BrFN5O2/c1-30-16-10-13(23)6-7-14(16)19-27-18-17(15(22)11-26-20(18)28-19)24-8-3-9-25-21(29)12-4-2-5-12/h6-7,10-12H,2-5,8-9H2,1H3,(H,25,29)(H2,24,26,27,28)
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n/an/an/an/a 34n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379366
PNG
(CHEMBL2011944)
Show SMILES COc1ccccc1-c1nc2ncc(Br)c(NCC(O)CNC(=O)C3CCC3)c2[nH]1
Show InChI InChI=1S/C21H24BrN5O3/c1-30-16-8-3-2-7-14(16)19-26-18-17(15(22)11-24-20(18)27-19)23-9-13(28)10-25-21(29)12-5-4-6-12/h2-3,7-8,11-13,28H,4-6,9-10H2,1H3,(H,25,29)(H2,23,24,26,27)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379359
PNG
(CHEMBL2011935)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CC(O)C3)c2[nH]1
Show InChI InChI=1S/C21H24BrN5O3/c1-30-15-5-3-12(4-6-15)19-26-18-17(16(22)11-25-20(18)27-19)23-7-2-8-24-21(29)13-9-14(28)10-13/h3-6,11,13-14,28H,2,7-10H2,1H3,(H,24,29)(H2,23,25,26,27)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379352
PNG
(CHEMBL2011928)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(C)=O)c2[nH]1
Show InChI InChI=1S/C18H20BrN5O2/c1-11(25)20-8-3-9-21-15-14(19)10-22-18-16(15)23-17(24-18)12-4-6-13(26-2)7-5-12/h4-7,10H,3,8-9H2,1-2H3,(H,20,25)(H2,21,22,23,24)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379351
PNG
(CHEMBL2011927)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(OCC3CCNCC3)c2[nH]1
Show InChI InChI=1S/C19H21BrN4O2/c1-25-14-4-2-13(3-5-14)18-23-16-17(15(20)10-22-19(16)24-18)26-11-12-6-8-21-9-7-12/h2-5,10,12,21H,6-9,11H2,1H3,(H,22,23,24)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379360
PNG
(CHEMBL2011937)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)c3ccccc3)c2[nH]1
Show InChI InChI=1S/C23H22BrN5O2/c1-31-17-10-8-15(9-11-17)21-28-20-19(18(24)14-27-22(20)29-21)25-12-5-13-26-23(30)16-6-3-2-4-7-16/h2-4,6-11,14H,5,12-13H2,1H3,(H,26,30)(H2,25,27,28,29)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379361
PNG
(CHEMBL2011938)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)c3cccnc3)c2[nH]1
Show InChI InChI=1S/C22H21BrN6O2/c1-31-16-7-5-14(6-8-16)20-28-19-18(17(23)13-27-21(19)29-20)25-10-3-11-26-22(30)15-4-2-9-24-12-15/h2,4-9,12-13H,3,10-11H2,1H3,(H,26,30)(H2,25,27,28,29)
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AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379350
PNG
(CHEMBL2011926)
Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCC3CCNCC3)c2[nH]1
Show InChI InChI=1S/C19H22BrN5O/c1-26-14-4-2-13(3-5-14)18-24-17-16(15(20)11-23-19(17)25-18)22-10-12-6-8-21-9-7-12/h2-5,11-12,21H,6-10H2,1H3,(H2,22,23,24,25)
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n/an/an/an/a 111n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379365
PNG
(CHEMBL2011943)
Show SMILES COc1ccc(cc1)-c1nc2ncc(C(N)=O)c(NCCCNC(=O)C3CCCC3)c2[nH]1
Show InChI InChI=1S/C23H28N6O3/c1-32-16-9-7-14(8-10-16)21-28-19-18(17(20(24)30)13-27-22(19)29-21)25-11-4-12-26-23(31)15-5-2-3-6-15/h7-10,13,15H,2-6,11-12H2,1H3,(H2,24,30)(H,26,31)(H2,25,27,28,29)
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n/an/an/an/a 139n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50379364
PNG
(CHEMBL2011942)
Show SMILES NC(=O)c1cnc2nc([nH]c2c1NCCCNC(=O)C1CCC1)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C28H37N7O3/c29-25(36)22-18-32-27-24(23(22)30-12-5-13-31-28(37)20-6-4-7-20)33-26(34-27)19-8-10-21(11-9-19)38-17-16-35-14-2-1-3-15-35/h8-11,18,20H,1-7,12-17H2,(H2,29,36)(H,31,37)(H2,30,32,33,34)
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n/an/an/an/a 1.46E+3n/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...


Bioorg Med Chem Lett 22: 2063-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.018
BindingDB Entry DOI: 10.7270/Q2WS8V74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of TBK1


J Med Chem 54: 2341-50 (2011)


Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>1.53E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TBK1


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM47117
PNG
(US8969335, A3)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cncc(c2)-c2cccnc2)c1
Show InChI InChI=1S/C27H23N5O2/c28-15-22-12-19(3-4-26(22)34-25-6-10-33-11-7-25)20-5-9-31-27(14-20)32-24-13-23(17-30-18-24)21-2-1-8-29-16-21/h1-5,8-9,12-14,16-18,25H,6-7,10-11H2,(H,31,32)
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n/an/a 260n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144182
PNG
(US8969335, A2)
Show SMILES CN1CCC(CC1)n1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C26H30N6O2/c1-31-10-5-23(6-11-31)32-18-22(17-29-32)30-26-15-20(4-9-28-26)19-2-3-25(21(14-19)16-27)34-24-7-12-33-13-8-24/h2-4,9,14-15,17-18,23-24H,5-8,10-13H2,1H3,(H,28,30)
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n/an/a 83n/an/an/an/a7.530



MERCK PATENT GmbH

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Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144183
PNG
(US8969335, A4)
Show SMILES Cc1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)no1
Show InChI InChI=1S/C21H20N4O3/c1-14-10-21(25-28-14)24-20-12-16(4-7-23-20)15-2-3-19(17(11-15)13-22)27-18-5-8-26-9-6-18/h2-4,7,10-12,18H,5-6,8-9H2,1H3,(H,23,24,25)
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n/an/a 34n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144184
PNG
(US8969335, A5)
Show SMILES Cn1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)n1
Show InChI InChI=1S/C21H21N5O2/c1-26-9-5-20(25-26)24-21-13-16(4-8-23-21)15-2-3-19(17(12-15)14-22)28-18-6-10-27-11-7-18/h2-5,8-9,12-13,18H,6-7,10-11H2,1H3,(H,23,24,25)
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n/an/a 97n/an/an/an/a7.530



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Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144185
PNG
(US8969335, A7)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2ccc(cn2)N2CCOCC2)c1
Show InChI InChI=1S/C26H27N5O3/c27-17-21-15-19(1-3-24(21)34-23-6-11-32-12-7-23)20-5-8-28-26(16-20)30-25-4-2-22(18-29-25)31-9-13-33-14-10-31/h1-5,8,15-16,18,23H,6-7,9-14H2,(H,28,29,30)
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n/an/a 8n/an/an/an/a7.530



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Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144186
PNG
(US8969335, A9)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2ccc(cn2)-c2cn[nH]c2)c1
Show InChI InChI=1S/C25H22N6O2/c26-13-20-11-17(1-3-23(20)33-22-6-9-32-10-7-22)18-5-8-27-25(12-18)31-24-4-2-19(14-28-24)21-15-29-30-16-21/h1-5,8,11-12,14-16,22H,6-7,9-10H2,(H,29,30)(H,27,28,31)
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n/an/a 120n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144187
PNG
(US8969335, A10)
Show SMILES CC(C)(C)c1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)n[nH]1
Show InChI InChI=1S/C24H27N5O2/c1-24(2,3)21-14-23(29-28-21)27-22-13-17(6-9-26-22)16-4-5-20(18(12-16)15-25)31-19-7-10-30-11-8-19/h4-6,9,12-14,19H,7-8,10-11H2,1-3H3,(H2,26,27,28,29)
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n/an/a 21n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144188
PNG
(US8969335, A11)
Show SMILES N#Cc1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)nc1
Show InChI InChI=1S/C23H19N5O2/c24-13-16-1-4-22(27-15-16)28-23-12-18(5-8-26-23)17-2-3-21(19(11-17)14-25)30-20-6-9-29-10-7-20/h1-5,8,11-12,15,20H,6-7,9-10H2,(H,26,27,28)
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n/an/a 250n/an/an/an/a7.530



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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144189
PNG
(US8969335, A12)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cc(n[nH]2)C2CC2)c1
Show InChI InChI=1S/C23H23N5O2/c24-14-18-11-16(3-4-21(18)30-19-6-9-29-10-7-19)17-5-8-25-22(12-17)26-23-13-20(27-28-23)15-1-2-15/h3-5,8,11-13,15,19H,1-2,6-7,9-10H2,(H2,25,26,27,28)
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n/an/a 30n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144190
PNG
(US8969335, A13)
Show SMILES FC(F)(F)c1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)nc1
Show InChI InChI=1S/C23H19F3N4O2/c24-23(25,26)18-2-4-21(29-14-18)30-22-12-16(5-8-28-22)15-1-3-20(17(11-15)13-27)32-19-6-9-31-10-7-19/h1-5,8,11-12,14,19H,6-7,9-10H2,(H,28,29,30)
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n/an/a 310n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144191
PNG
(US8969335, A14)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2ncccn2)c1
Show InChI InChI=1S/C21H19N5O2/c22-14-17-12-15(2-3-19(17)28-18-5-10-27-11-6-18)16-4-9-23-20(13-16)26-21-24-7-1-8-25-21/h1-4,7-9,12-13,18H,5-6,10-11H2,(H,23,24,25,26)
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n/an/a 670n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144192
PNG
(US8969335, A15)
Show SMILES OCc1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)nc1
Show InChI InChI=1S/C23H22N4O3/c24-13-19-11-17(2-3-21(19)30-20-6-9-29-10-7-20)18-5-8-25-23(12-18)27-22-4-1-16(15-28)14-26-22/h1-5,8,11-12,14,20,28H,6-7,9-10,15H2,(H,25,26,27)
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n/an/a 14n/an/an/an/a7.530



MERCK PATENT GmbH

US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144193
PNG
(US8969335, A16)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cnn(c2)C2CCNCC2)c1
Show InChI InChI=1S/C25H28N6O2/c26-15-20-13-18(1-2-24(20)33-23-6-11-32-12-7-23)19-3-10-28-25(14-19)30-21-16-29-31(17-21)22-4-8-27-9-5-22/h1-3,10,13-14,16-17,22-23,27H,4-9,11-12H2,(H,28,30)
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n/an/a 71n/an/an/an/a7.530



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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144194
PNG
(US8969335, A18)
Show SMILES OCc1ccnc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)c1
Show InChI InChI=1S/C23H22N4O3/c24-14-19-12-17(1-2-21(19)30-20-5-9-29-10-6-20)18-4-8-26-23(13-18)27-22-11-16(15-28)3-7-25-22/h1-4,7-8,11-13,20,28H,5-6,9-10,15H2,(H,25,26,27)
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n/an/a 8n/an/an/an/a7.530



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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144195
PNG
(US8969335, A19)
Show SMILES NC(=O)c1cc2cc(Nc3cc(ccn3)-c3ccc(OC4CCOCC4)c(c3)C#N)ccc2o1
Show InChI InChI=1S/C26H22N4O4/c27-15-19-11-16(1-3-23(19)33-21-6-9-32-10-7-21)17-5-8-29-25(14-17)30-20-2-4-22-18(12-20)13-24(34-22)26(28)31/h1-5,8,11-14,21H,6-7,9-10H2,(H2,28,31)(H,29,30)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144196
PNG
(US8969335, A20)
Show SMILES FC(F)Cn1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C22H21F2N5O2/c23-21(24)14-29-13-18(12-27-29)28-22-10-16(3-6-26-22)15-1-2-20(17(9-15)11-25)31-19-4-7-30-8-5-19/h1-3,6,9-10,12-13,19,21H,4-5,7-8,14H2,(H,26,28)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144197
PNG
(US8969335, A21)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cnn(CCC3CCNCC3)c2)c1
Show InChI InChI=1S/C27H32N6O2/c28-17-23-15-21(1-2-26(23)35-25-7-13-34-14-8-25)22-5-11-30-27(16-22)32-24-18-31-33(19-24)12-6-20-3-9-29-10-4-20/h1-2,5,11,15-16,18-20,25,29H,3-4,6-10,12-14H2,(H,30,32)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144198
PNG
(US8969335, A22)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cnn(CCN3CCOCC3)c2)c1
Show InChI InChI=1S/C26H30N6O3/c27-17-22-15-20(1-2-25(22)35-24-4-11-33-12-5-24)21-3-6-28-26(16-21)30-23-18-29-32(19-23)8-7-31-9-13-34-14-10-31/h1-3,6,15-16,18-19,24H,4-5,7-14H2,(H,28,30)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144199
PNG
(US8969335, A23)
Show SMILES COCCCn1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C24H27N5O3/c1-30-10-2-9-29-17-21(16-27-29)28-24-14-19(5-8-26-24)18-3-4-23(20(13-18)15-25)32-22-6-11-31-12-7-22/h3-5,8,13-14,16-17,22H,2,6-7,9-12H2,1H3,(H,26,28)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144200
PNG
(US8969335, A24)
Show SMILES N#CC1CC1Cn1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C25H24N6O2/c26-12-19-10-21(19)15-31-16-22(14-29-31)30-25-11-18(3-6-28-25)17-1-2-24(20(9-17)13-27)33-23-4-7-32-8-5-23/h1-3,6,9,11,14,16,19,21,23H,4-5,7-8,10,15H2,(H,28,30)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144201
PNG
(US8969335, A25)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cnn(c2)C2CNC2)c1
Show InChI InChI=1S/C23H24N6O2/c24-11-18-9-16(1-2-22(18)31-21-4-7-30-8-5-21)17-3-6-26-23(10-17)28-19-12-27-29(15-19)20-13-25-14-20/h1-3,6,9-10,12,15,20-21,25H,4-5,7-8,13-14H2,(H,26,28)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144202
PNG
(US8969335, A26)
Show SMILES OC[C@H]1C[C@@H]1Cn1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C25H27N5O3/c26-12-19-9-17(1-2-24(19)33-23-4-7-32-8-5-23)18-3-6-27-25(11-18)29-22-13-28-30(15-22)14-20-10-21(20)16-31/h1-3,6,9,11,13,15,20-21,23,31H,4-5,7-8,10,14,16H2,(H,27,29)/t20-,21-/m1/s1
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144203
PNG
(US8969335, A27)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cnn(CC3CCOC3)c2)c1
Show InChI InChI=1S/C25H27N5O3/c26-13-21-11-19(1-2-24(21)33-23-5-9-31-10-6-23)20-3-7-27-25(12-20)29-22-14-28-30(16-22)15-18-4-8-32-17-18/h1-3,7,11-12,14,16,18,23H,4-6,8-10,15,17H2,(H,27,29)
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Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144204
PNG
(US8969335, A28)
Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2cnn(c2)C2CCNC2)c1
Show InChI InChI=1S/C24H26N6O2/c25-13-19-11-17(1-2-23(19)32-22-5-9-31-10-6-22)18-3-8-27-24(12-18)29-20-14-28-30(16-20)21-4-7-26-15-21/h1-3,8,11-12,14,16,21-22,26H,4-7,9-10,15H2,(H,27,29)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144205
PNG
(US8969335, A29)
Show SMILES OCC(=O)N1CCC(CCn2cc(Nc3cc(ccn3)-c3ccc(OC4CCOCC4)c(c3)C#N)cn2)CC1
Show InChI InChI=1S/C29H34N6O4/c30-17-24-15-22(1-2-27(24)39-26-7-13-38-14-8-26)23-3-9-31-28(16-23)33-25-18-32-35(19-25)12-6-21-4-10-34(11-5-21)29(37)20-36/h1-3,9,15-16,18-19,21,26,36H,4-8,10-14,20H2,(H,31,33)
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US Patent


Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144206
PNG
(US8969335, A30)
Show SMILES NCC(=O)N1CCC(CCn2cc(Nc3cc(ccn3)-c3ccc(OC4CCOCC4)c(c3)C#N)cn2)CC1
Show InChI InChI=1S/C29H35N7O3/c30-17-24-15-22(1-2-27(24)39-26-7-13-38-14-8-26)23-3-9-32-28(16-23)34-25-19-33-36(20-25)12-6-21-4-10-35(11-5-21)29(37)18-31/h1-3,9,15-16,19-21,26H,4-8,10-14,18,31H2,(H,32,34)
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Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM144207
PNG
(US8969335, A31)
Show SMILES CC(C)(C)c1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)on1
Show InChI InChI=1S/C24H26N4O3/c1-24(2,3)21-14-23(31-28-21)27-22-13-17(6-9-26-22)16-4-5-20(18(12-16)15-25)30-19-7-10-29-11-8-19/h4-6,9,12-14,19H,7-8,10-11H2,1-3H3,(H,26,27)
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Assay Description
The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...


US Patent US8969335 (2015)


BindingDB Entry DOI: 10.7270/Q25X27NN
More data for this
Ligand-Target Pair
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