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Compile Data Set for Download or QSAR

Found 22 hits Enz. Inhib. hit(s) with Target = 'Serine protease NS5A (L28T)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245924
PNG
(US9433609, 17)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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PC sid
UniChem
n/an/an/an/a 0.0370n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243436
PNG
(US9427428, 17 | US9427428, 21)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34-,35-,36-,37-/m0/s1
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PC sid
UniChem
n/an/an/an/a 0.0370n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243437
PNG
(US9427428, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34+,35-,36-,37-/m0/s1
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PC sid
UniChem
n/an/an/an/a 0.0410n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245925
PNG
(US9433609, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2cc(ccc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.0410n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243435
PNG
(US9427428, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C42H48N8O8/c1-23(55-3)35(47-41(53)57-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(2)56-4)48-42(54)58-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t23-,24-,33+,34+,35+,36+/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.0520n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245918
PNG
(US9433609, 2 | US9433609, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C38H46N8O7/c1-21(2)31(43-37(49)52-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)51-4)44-38(50)53-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t22-,29+,30+,31+,32+/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.0520n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.0810n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.0810n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.109n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.109n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.117n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243438
PNG
(US9427428, 11)
Show SMILES CO[C@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33-,34+,35-,36-/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.117n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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PC sid
UniChem
n/an/an/an/a 0.151n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.151n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.206n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.206n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.229n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 0.229n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245917
PNG
(US9433609, 1)
Show SMILES COC(=O)NC(C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C38H46N8O6/c1-21(2)31(43-37(49)51-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)4)44-38(50)52-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t29-,30-,31?,32-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 4.12n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243442
PNG
(US9427428, 1)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C38H46N8O6/c1-21(2)31(43-37(49)51-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)4)44-38(50)52-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t29-,30-,31-,32-/m0/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 4.12n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243441
PNG
(US9427428, 2)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC
Show InChI InChI=1S/C38H46N8O8/c1-21(51-3)31(43-37(49)53-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(2)52-4)44-38(50)54-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t21-,22-,29+,30+,31+,32+/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 9.05n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245918
PNG
(US9433609, 2 | US9433609, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
Show InChI InChI=1S/C38H46N8O7/c1-21(2)31(43-37(49)52-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)51-4)44-38(50)53-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t22-,29+,30+,31+,32+/m1/s1
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PC cid
PC sid
UniChem
n/an/an/an/a 9.05n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair