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Compile Data Set for Download or QSAR

Found 31 hits Enz. Inhib. hit(s) with Target = 'Short transient receptor potential channel 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50239161
PNG
(CHEMBL4085233)
Show SMILES CCOC(=O)N1CCC(CC1)c1cc(O)n2nc(C)c(-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H23F3N4O3/c1-3-32-21(31)28-10-8-14(9-11-28)17-12-18(30)29-20(26-17)19(13(2)27-29)15-4-6-16(7-5-15)22(23,24)25/h4-7,12,14,30H,3,8-11H2,1-2H3
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n/an/an/an/a 19n/an/an/an/a



Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Provinc

Curated by ChEMBL


Assay Description
Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...


J Med Chem 60: 4680-4692 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00304
BindingDB Entry DOI: 10.7270/Q2D220RN
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50239160
PNG
(CHEMBL4060387)
Show SMILES Cc1nn2c(O)cc(nc2c1-c1ccc(Cl)cc1)C1CCN(CC1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H25ClN4O3/c1-17-24(20-7-9-21(27)10-8-20)25-28-22(15-23(32)31(25)29-17)19-11-13-30(14-12-19)26(33)34-16-18-5-3-2-4-6-18/h2-10,15,19,32H,11-14,16H2,1H3
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n/an/an/an/a 138n/an/an/an/a



Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Provinc

Curated by ChEMBL


Assay Description
Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...


J Med Chem 60: 4680-4692 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00304
BindingDB Entry DOI: 10.7270/Q2D220RN
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50239162
PNG
(CHEMBL4060400)
Show SMILES Cc1nn2c(O)cc(nc2c1-c1ccc(F)cc1)C1CCN(CC1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H25FN4O3/c1-17-24(20-7-9-21(27)10-8-20)25-28-22(15-23(32)31(25)29-17)19-11-13-30(14-12-19)26(33)34-16-18-5-3-2-4-6-18/h2-10,15,19,32H,11-14,16H2,1H3
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n/an/an/an/a 236n/an/an/an/a



Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Provinc

Curated by ChEMBL


Assay Description
Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate.


J Med Chem 60: 4680-4692 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00304
BindingDB Entry DOI: 10.7270/Q2D220RN
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50239167
PNG
(CHEMBL1496110)
Show SMILES CCOC(=O)N1CCC(CC1)c1cc(O)n2nc(C)c(-c3ccc(F)cc3)c2n1
Show InChI InChI=1S/C21H23FN4O3/c1-3-29-21(28)25-10-8-14(9-11-25)17-12-18(27)26-20(23-17)19(13(2)24-26)15-4-6-16(22)7-5-15/h4-7,12,14,27H,3,8-11H2,1-2H3
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n/an/an/an/a 450n/an/an/an/a



Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Provinc

Curated by ChEMBL


Assay Description
Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...


J Med Chem 60: 4680-4692 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00304
BindingDB Entry DOI: 10.7270/Q2D220RN
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50044849
PNG
(CHEMBL3311308)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
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n/an/an/an/a<5.01E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Induction of human TRPC3 opening expressed in HEK cells by MSRII FLIPR/summary (Abse5) assay


Bioorg Med Chem Lett 24: 3100-3 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.012
BindingDB Entry DOI: 10.7270/Q2CC1292
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM43434
PNG
(3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanili...)
Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439216
PNG
(CHEMBL2418812)
Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C
Show InChI InChI=1/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/s2
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n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439217
PNG
(CHEMBL2418811)
Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C
Show InChI InChI=1/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/s2
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439216
PNG
(CHEMBL2418812)
Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C
Show InChI InChI=1/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/s2
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n/an/a 250n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439218
PNG
(CHEMBL2418809)
Show SMILES CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1Cl
Show InChI InChI=1/C18H19ClFN3O3S/c1-9-4-3-5-23(10(9)2)17(24)15-16(19)27-18(22-15)21-12-7-14-13(6-11(12)20)25-8-26-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,21,22)
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439219
PNG
(CHEMBL2418808)
Show SMILES CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1C
Show InChI InChI=1/C19H22FN3O3S/c1-10-5-4-6-23(11(10)2)18(24)17-12(3)27-19(22-17)21-14-8-16-15(7-13(14)20)25-9-26-16/h7-8,10-11H,4-6,9H2,1-3H3,(H,21,22)
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n/an/a 160n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439220
PNG
(CHEMBL2418807)
Show SMILES CC1CCCN(C1C)C(=O)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1/C18H21N3O3S/c1-11-4-3-7-21(12(11)2)17(22)14-9-25-18(20-14)19-13-5-6-15-16(8-13)24-10-23-15/h5-6,8-9,11-12H,3-4,7,10H2,1-2H3,(H,19,20)
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n/an/a 80n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439221
PNG
(CHEMBL2418806)
Show SMILES CC1CCCN(C1C)C(=O)c1csc(Nc2ccc(C)cc2)n1
Show InChI InChI=1/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20)
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n/an/a 250n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439222
PNG
(CHEMBL2418805)
Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C22H29N3OS/c1-16-7-9-19(10-8-16)23-22-24-20(15-27-22)21(26)25-13-11-18(12-14-25)17-5-3-2-4-6-17/h7-10,15,17-18H,2-6,11-14H2,1H3,(H,23,24)
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n/an/a 6.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439223
PNG
(CHEMBL2418804)
Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H23N3O2S/c1-27-19-9-7-18(8-10-19)23-22-24-20(15-28-22)21(26)25-13-11-17(12-14-25)16-5-3-2-4-6-16/h2-10,15,17H,11-14H2,1H3,(H,23,24)
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n/an/a 2.50E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439224
PNG
(CHEMBL2417565)
Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCCC(C2)c2ccccc2)cc1
Show InChI InChI=1/C22H23N3OS/c1-16-9-11-19(12-10-16)23-22-24-20(15-27-22)21(26)25-13-5-8-18(14-25)17-6-3-2-4-7-17/h2-4,6-7,9-12,15,18H,5,8,13-14H2,1H3,(H,23,24)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439225
PNG
(CHEMBL2418825)
Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCCCC2c2ccccc2)cc1
Show InChI InChI=1/C22H23N3OS/c1-16-10-12-18(13-11-16)23-22-24-19(15-27-22)21(26)25-14-6-5-9-20(25)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24)
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n/an/a 1.26E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439226
PNG
(CHEMBL2418824)
Show SMILES CC1CCCCN1C(=O)c1csc(Nc2ccc(C)cc2)n1
Show InChI InChI=1/C17H21N3OS/c1-12-6-8-14(9-7-12)18-17-19-15(11-22-17)16(21)20-10-4-3-5-13(20)2/h6-9,11,13H,3-5,10H2,1-2H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439227
PNG
(CHEMBL2418823)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C17H19N3O3S/c1-11-4-6-20(7-5-11)16(21)13-9-24-17(19-13)18-12-2-3-14-15(8-12)23-10-22-14/h2-3,8-9,11H,4-7,10H2,1H3,(H,18,19)
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439228
PNG
(CHEMBL2418822)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C16H17ClFN3OS/c1-10-4-6-21(7-5-10)15(22)14-9-23-16(20-14)19-13-3-2-11(17)8-12(13)18/h2-3,8-10H,4-7H2,1H3,(H,19,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439229
PNG
(CHEMBL2418821)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccccc2Cl)n1
Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-5-3-2-4-12(13)17/h2-5,10-11H,6-9H2,1H3,(H,18,19)
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n/an/a 6.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439230
PNG
(CHEMBL2418820)
Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCC(C)CC2)cc1
Show InChI InChI=1S/C17H21N3O2S/c1-12-7-9-20(10-8-12)16(21)15-11-23-17(19-15)18-13-3-5-14(22-2)6-4-13/h3-6,11-12H,7-10H2,1-2H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439231
PNG
(CHEMBL2418819)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-4-2-12(17)3-5-13/h2-5,10-11H,6-9H2,1H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439232
PNG
(CHEMBL2418818)
Show SMILES CC1CCN(CC1)C(=O)c1csc(Nc2ccc(C)cc2)n1
Show InChI InChI=1S/C17H21N3OS/c1-12-3-5-14(6-4-12)18-17-19-15(11-22-17)16(21)20-9-7-13(2)8-10-20/h3-6,11,13H,7-10H2,1-2H3,(H,18,19)
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n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50232797
PNG
(CHEMBL4073922)
Show SMILES FC(F)(F)c1cccc(c1)-c1nc2cc(Br)ccc2c(C(=O)NC2(CC2)c2ccccc2)c1CN1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of TRPC3 (unknown origin)


ACS Med Chem Lett 8: 549-554 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00094
BindingDB Entry DOI: 10.7270/Q2HD7XWW
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439215
PNG
(CHEMBL2418813)
Show SMILES O=C(N1CCc2ccccc2C1)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C20H17N3O3S/c24-19(23-8-7-13-3-1-2-4-14(13)10-23)16-11-27-20(22-16)21-15-5-6-17-18(9-15)26-12-25-17/h1-6,9,11H,7-8,10,12H2,(H,21,22)
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n/an/a 500n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439214
PNG
(CHEMBL2418814)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1csc(Nc2ccc3OCOc3c2)n1
Show InChI InChI=1/C21H19N3O3S/c1-13-16-5-3-2-4-14(16)8-9-24(13)20(25)17-11-28-21(23-17)22-15-6-7-18-19(10-15)27-12-26-18/h2-7,10-11,13H,8-9,12H2,1H3,(H,22,23)
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439213
PNG
(CHEMBL2418815)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C
Show InChI InChI=1/C22H21N3O3S/c1-13-17-6-4-3-5-15(17)9-10-25(13)21(26)20-14(2)29-22(24-20)23-16-7-8-18-19(11-16)28-12-27-18/h3-8,11,13H,9-10,12H2,1-2H3,(H,23,24)
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439212
PNG
(CHEMBL2418816)
Show SMILES CC1N(CCc2ncccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C
Show InChI InChI=1/C21H20N4O3S/c1-12-15-4-3-8-22-16(15)7-9-25(12)20(26)19-13(2)29-21(24-19)23-14-5-6-17-18(10-14)28-11-27-17/h3-6,8,10,12H,7,9,11H2,1-2H3,(H,23,24)
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n/an/a 1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50439211
PNG
(CHEMBL2418817)
Show SMILES Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCc2ncccc2C1
Show InChI InChI=1S/C19H16ClFN4OS/c1-11-17(18(26)25-8-6-15-12(10-25)3-2-7-22-15)24-19(27-11)23-16-5-4-13(20)9-14(16)21/h2-5,7,9H,6,8,10H2,1H3,(H,23,24)
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n/an/a 2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay


Bioorg Med Chem Lett 23: 4979-84 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H
More data for this
Ligand-Target Pair
Short transient receptor potential channel 3


(Homo sapiens (Human))
BDBM50044849
PNG
(CHEMBL3311308)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
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n/an/a<3.98E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Blocking of human TRPC3 expressed in HEK cells by MSRII FLIPR/summary (Abse5) assay


Bioorg Med Chem Lett 24: 3100-3 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.012
BindingDB Entry DOI: 10.7270/Q2CC1292
More data for this
Ligand-Target Pair