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Compile Data Set for Download or QSAR

Found 307 hits Enz. Inhib. hit(s) with Target = 'Sigma non-opioid intracellular receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312233
PNG
(US9604926, Compound AZ-66 | US9724435, Compound AZ...)
Show SMILES CC(CCCn1c2ccc(F)cc2sc1=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1/C22H32FN3OS/c1-17(24-12-14-25(15-13-24)19-7-3-2-4-8-19)6-5-11-26-20-10-9-18(23)16-21(20)28-22(26)27/h9-10,16-17,19H,2-8,11-15H2,1H3
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0.310n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312168
PNG
(US9604926, Compound CM-172 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c25-22-24(20-10-4-5-11-21(20)26-22)15-7-6-14-23-16-12-19(13-17-23)18-8-2-1-3-9-18/h1-5,8-11,19H,6-7,12-17H2
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0.580n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312167
PNG
(US9604926, Compound CM-171 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C22H33N3O2/c26-22-25(20-10-4-5-11-21(20)27-22)13-7-6-12-23-14-16-24(17-15-23)18-19-8-2-1-3-9-19/h4-5,10-11,19H,1-3,6-9,12-18H2
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0.940n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002254
PNG
(2-(1-Benzyl-piperidin-4-yl)-1-(4-fluoro-phenyl)-et...)
Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H22FNO/c21-19-8-6-18(7-9-19)20(23)14-16-10-12-22(13-11-16)15-17-4-2-1-3-5-17/h1-9,16H,10-15H2
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1n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50374598
PNG
(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Show SMILES S=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3S2/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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1.28n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312174
PNG
(US9604926, Compound CM-176 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCN1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C21H25N3O2/c25-21-24(19-8-4-5-9-20(19)26-21)17-16-23-14-12-22(13-15-23)11-10-18-6-2-1-3-7-18/h1-9H,10-17H2
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1.43n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50017233
PNG
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/s2
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1.90n/an/an/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding affinity for mouse sigma opioid receptor


J Med Chem 32: 2221-6 (1989)


Article DOI: 10.1021/jm00129a031
BindingDB Entry DOI: 10.7270/Q2Q240T3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002292
PNG
(4-[4-(4-Fluoro-benzyloxymethyl)-piperidin-1-ylmeth...)
Show SMILES Fc1ccc(COCC2CCN(Cc3ccncc3)CC2)cc1
Show InChI InChI=1S/C19H23FN2O/c20-19-3-1-17(2-4-19)14-23-15-18-7-11-22(12-8-18)13-16-5-9-21-10-6-16/h1-6,9-10,18H,7-8,11-15H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002252
PNG
(1-Benzyl-4-(4-fluoro-phenoxymethyl)-piperidine; hy...)
Show SMILES Fc1ccc(OCC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C19H22FNO/c20-18-6-8-19(9-7-18)22-15-17-10-12-21(13-11-17)14-16-4-2-1-3-5-16/h1-9,17H,10-15H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002275
PNG
(1-Benzyl-4-(3-phenyl-propoxy)-piperidine; compound...)
Show SMILES C(COC1CCN(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-8-19(9-4-1)12-7-17-23-21-13-15-22(16-14-21)18-20-10-5-2-6-11-20/h1-6,8-11,21H,7,12-18H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002232
PNG
(1-Benzyl-4-(4-phenyl-butoxymethyl)-piperidine; hyd...)
Show SMILES C(CCc1ccccc1)COCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H31NO/c1-3-9-21(10-4-1)11-7-8-18-25-20-23-14-16-24(17-15-23)19-22-12-5-2-6-13-22/h1-6,9-10,12-13,23H,7-8,11,14-20H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002235
PNG
(1-Benzyl-4-(4-trifluoromethyl-phenoxymethyl)-piper...)
Show SMILES FC(F)(F)c1ccc(OCC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H22F3NO/c21-20(22,23)18-6-8-19(9-7-18)25-15-17-10-12-24(13-11-17)14-16-4-2-1-3-5-16/h1-9,17H,10-15H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002209
PNG
(1-(2,2-Dichloro-1-methyl-cyclopropylmethyl)-4-(4-f...)
Show SMILES CC1(CN2CCC(COc3ccc(F)cc3)CC2)CC1(Cl)Cl
Show InChI InChI=1/C17H22Cl2FNO/c1-16(11-17(16,18)19)12-21-8-6-13(7-9-21)10-22-15-4-2-14(20)3-5-15/h2-5,13H,6-12H2,1H3
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002219
PNG
(1-Benzyl-4-cyclopropoxymethyl-piperidine; compound...)
Show SMILES C(OC1CC1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C16H23NO/c1-2-4-14(5-3-1)12-17-10-8-15(9-11-17)13-18-16-6-7-16/h1-5,15-16H,6-13H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002190
PNG
(1-Benzyl-4-(4-fluoro-benzyloxymethyl)-piperidine; ...)
Show SMILES Fc1ccc(COCC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H24FNO/c21-20-8-6-18(7-9-20)15-23-16-19-10-12-22(13-11-19)14-17-4-2-1-3-5-17/h1-9,19H,10-16H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002229
PNG
(1-Benzyl-4-cyclohexyloxymethyl-piperidine; hydroch...)
Show SMILES C(OC1CCCCC1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H29NO/c1-3-7-17(8-4-1)15-20-13-11-18(12-14-20)16-21-19-9-5-2-6-10-19/h1,3-4,7-8,18-19H,2,5-6,9-16H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002241
PNG
(1-(4-Chloro-benzyl)-4-(4-fluoro-benzyloxymethyl)-p...)
Show SMILES Fc1ccc(COCC2CCN(Cc3ccc(Cl)cc3)CC2)cc1
Show InChI InChI=1S/C20H23ClFNO/c21-19-5-1-16(2-6-19)13-23-11-9-18(10-12-23)15-24-14-17-3-7-20(22)8-4-17/h1-8,18H,9-15H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002207
PNG
(1-Cyclopropylmethyl-4-(4-fluoro-phenoxymethyl)-pip...)
Show SMILES Fc1ccc(OCC2CCN(CC3CC3)CC2)cc1
Show InChI InChI=1S/C16H22FNO/c17-15-3-5-16(6-4-15)19-12-14-7-9-18(10-8-14)11-13-1-2-13/h3-6,13-14H,1-2,7-12H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002303
PNG
(1-Cyclopropylmethyl-4-(3,4-difluoro-phenoxymethyl)...)
Show SMILES Fc1ccc(OCC2CCN(CC3CC3)CC2)cc1F
Show InChI InChI=1S/C16H21F2NO/c17-15-4-3-14(9-16(15)18)20-11-13-5-7-19(8-6-13)10-12-1-2-12/h3-4,9,12-13H,1-2,5-8,10-11H2
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2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312234
PNG
(US9604926, Compound AZ-68 | US9724435, Compound AZ...)
Show SMILES Fc1ccc2n(CCCCN3CCN(CC3)C3CCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C21H30FN3OS/c22-17-8-9-19-20(16-17)27-21(26)25(19)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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2.01n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312227
PNG
(US9604926, Compound SC-6 | US9724435, Compound SC-...)
Show SMILES CCCc1ccc2n(CCN3CCN(CC3)C3CCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C22H33N3OS/c1-2-6-18-9-10-20-21(17-18)27-22(26)25(20)16-13-23-11-14-24(15-12-23)19-7-4-3-5-8-19/h9-10,17,19H,2-8,11-16H2,1H3
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2.15n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312154
PNG
(US9604926, Compound CM-146 | US9724435, Compound C...)
Show SMILES CCc1ccc2n(CCCCN3CCN(CC3)C3CCCCC3)c(=O)oc2c1
Show InChI InChI=1S/C23H35N3O2/c1-2-19-10-11-21-22(18-19)28-23(27)26(21)13-7-6-12-24-14-16-25(17-15-24)20-8-4-3-5-9-20/h10-11,18,20H,2-9,12-17H2,1H3
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2.18n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50017232
PNG
(3-Cyclopropylmethyl-5-ethyl-8-hydroxy-11-methyl-3,...)
Show SMILES CCC1CN(CC2CC2)C2C(C)C1c1cc(O)ccc1C2=O
Show InChI InChI=1/C19H25NO2/c1-3-13-10-20(9-12-4-5-12)18-11(2)17(13)16-8-14(21)6-7-15(16)19(18)22/h6-8,11-13,17-18,21H,3-5,9-10H2,1-2H3
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2.30n/an/an/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding affinity for mouse sigma opioid receptor


J Med Chem 32: 2221-6 (1989)


Article DOI: 10.1021/jm00129a031
BindingDB Entry DOI: 10.7270/Q2Q240T3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312178
PNG
(US9604926, Compound CM-181 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCN1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C20H29N3O2/c24-20-23(18-8-4-5-9-19(18)25-20)15-14-21-10-12-22(13-11-21)16-17-6-2-1-3-7-17/h4-5,8-9,17H,1-3,6-7,10-16H2
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2.36n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312161
PNG
(US9604926, Compound CM-165 | US9724435, Compound C...)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCn2c3ccccc3oc2=O)CC1
Show InChI InChI=1S/C22H23ClN2O2/c23-19-9-7-17(8-10-19)18-11-15-24(16-12-18)13-3-4-14-25-20-5-1-2-6-21(20)27-22(25)26/h1-2,5-11H,3-4,12-16H2
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2.40n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312203
PNG
(US9604926, Compound CM-401 | US9724435, Compound C...)
Show SMILES CC(=O)c1ccc2n(CCCCN3CCC(=CC3)c3ccc(F)cc3)c(=O)oc2c1
Show InChI InChI=1S/C24H25FN2O3/c1-17(28)20-6-9-22-23(16-20)30-24(29)27(22)13-3-2-12-26-14-10-19(11-15-26)18-4-7-21(25)8-5-18/h4-10,16H,2-3,11-15H2,1H3
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2.89n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002272
PNG
(1-(2-Cyclopropyl-ethyl)-4-(4-fluoro-phenoxymethyl)...)
Show SMILES Fc1ccc(OCC2CCN(CCC3CC3)CC2)cc1
Show InChI InChI=1S/C17H24FNO/c18-16-3-5-17(6-4-16)20-13-15-8-11-19(12-9-15)10-7-14-1-2-14/h3-6,14-15H,1-2,7-13H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002197
PNG
(1-(1-Benzyl-piperidin-4-yl)-3-(4-fluoro-phenyl)-pr...)
Show SMILES Fc1ccc(CC(=O)CC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H24FNO/c22-20-8-6-17(7-9-20)14-21(24)15-18-10-12-23(13-11-18)16-19-4-2-1-3-5-19/h1-9,18H,10-16H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002263
PNG
(1-Cyclohexylmethyl-4-(4-fluoro-benzyloxymethyl)-pi...)
Show SMILES Fc1ccc(COCC2CCN(CC3CCCCC3)CC2)cc1
Show InChI InChI=1S/C20H30FNO/c21-20-8-6-18(7-9-20)15-23-16-19-10-12-22(13-11-19)14-17-4-2-1-3-5-17/h6-9,17,19H,1-5,10-16H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002250
PNG
(1-(4-Fluoro-phenyl)-2-[1-(4-trifluoromethyl-benzyl...)
Show SMILES Fc1ccc(cc1)C(=O)CC1CCN(Cc2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21F4NO/c22-19-7-3-17(4-8-19)20(27)13-15-9-11-26(12-10-15)14-16-1-5-18(6-2-16)21(23,24)25/h1-8,15H,9-14H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002187
PNG
(1-(1-Benzyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-et...)
Show SMILES OC(Cc1ccc(F)cc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1/C20H24FNO/c21-19-8-6-16(7-9-19)14-20(23)18-10-12-22(13-11-18)15-17-4-2-1-3-5-17/h1-9,18,20,23H,10-15H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002284
PNG
(1-Benzyl-4-(4-methoxy-phenoxymethyl)-piperidine | ...)
Show SMILES COc1ccc(OCC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H25NO2/c1-22-19-7-9-20(10-8-19)23-16-18-11-13-21(14-12-18)15-17-5-3-2-4-6-17/h2-10,18H,11-16H2,1H3
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002280
PNG
(1-(1-Benzyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-et...)
Show SMILES Fc1ccc(CC(=O)C2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H22FNO/c21-19-8-6-16(7-9-19)14-20(23)18-10-12-22(13-11-18)15-17-4-2-1-3-5-17/h1-9,18H,10-15H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002217
PNG
(2-[1-(4-Fluoro-benzyl)-piperidin-4-yl]-1-(4-fluoro...)
Show SMILES Fc1ccc(CN2CCC(CC(=O)c3ccc(F)cc3)CC2)cc1
Show InChI InChI=1S/C20H21F2NO/c21-18-5-1-16(2-6-18)14-23-11-9-15(10-12-23)13-20(24)17-3-7-19(22)8-4-17/h1-8,15H,9-14H2
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3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312162
PNG
(US9604926, Compound CM-166 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H29N3O2/c27-23-26(21-10-4-5-11-22(21)28-23)14-7-6-13-24-16-18-25(19-17-24)15-12-20-8-2-1-3-9-20/h1-5,8-11H,6-7,12-19H2
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3.15n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002268
PNG
(1-Benzyl-4-(3-phenyl-propoxymethyl)-piperidine; co...)
Show SMILES C(COCC1CCN(Cc2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C22H29NO/c1-3-8-20(9-4-1)12-7-17-24-19-22-13-15-23(16-14-22)18-21-10-5-2-6-11-21/h1-6,8-11,22H,7,12-19H2
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3.20n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50353845
PNG
(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Show SMILES C(CCn1ccc2ccccc12)CN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H33N3/c1-2-9-21(10-3-1)24-18-16-23(17-19-24)13-6-7-14-25-15-12-20-8-4-5-11-22(20)25/h4-5,8,11-12,15,21H,1-3,6-7,9-10,13-14,16-19H2
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3.28n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312147
PNG
(US9604926, Compound SN-72 | US9724435, Compound SN...)
Show SMILES CCCc1ccc2oc(=O)n(CCN3CCCCCC3)c2c1
Show InChI InChI=1S/C18H26N2O2/c1-2-7-15-8-9-17-16(14-15)20(18(21)22-17)13-12-19-10-5-3-4-6-11-19/h8-9,14H,2-7,10-13H2,1H3
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3.33n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50374601
PNG
(CHEMBL408003 | US9604926, Compound CM-135 | US9724...)
Show SMILES C(CCN1CCN(CC1)C1CCCCC1)CSc1nc2ccccc2o1
Show InChI InChI=1S/C21H31N3OS/c1-2-8-18(9-3-1)24-15-13-23(14-16-24)12-6-7-17-26-21-22-19-10-4-5-11-20(19)25-21/h4-5,10-11,18H,1-3,6-9,12-17H2
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3.37n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002267
PNG
(1-Benzyl-4-(4-methoxy-benzyloxymethyl)-piperidine;...)
Show SMILES COc1ccc(COCC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H27NO2/c1-23-21-9-7-19(8-10-21)16-24-17-20-11-13-22(14-12-20)15-18-5-3-2-4-6-18/h2-10,20H,11-17H2,1H3
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3.5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002290
PNG
(1-Benzyl-4-[2-(4-fluoro-phenoxy)-ethyl]-piperidine...)
Show SMILES Fc1ccc(OCCC2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H24FNO/c21-19-6-8-20(9-7-19)23-15-12-17-10-13-22(14-11-17)16-18-4-2-1-3-5-18/h1-9,17H,10-16H2
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002256
PNG
(4-(4-Fluoro-benzyloxymethyl)-1-naphthalen-2-ylmeth...)
Show SMILES Fc1ccc(COCC2CCN(Cc3ccc4ccccc4c3)CC2)cc1
Show InChI InChI=1S/C24H26FNO/c25-24-9-6-19(7-10-24)17-27-18-20-11-13-26(14-12-20)16-21-5-8-22-3-1-2-4-23(22)15-21/h1-10,15,20H,11-14,16-18H2
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002189
PNG
(2-(1-Benzyl-piperidin-4-yl)-1-(4-methoxy-phenyl)-e...)
Show SMILES COc1ccc(cc1)C(=O)CC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H25NO2/c1-24-20-9-7-19(8-10-20)21(23)15-17-11-13-22(14-12-17)16-18-5-3-2-4-6-18/h2-10,17H,11-16H2,1H3
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002222
PNG
(1-Benzyl-4-benzyloxymethyl-piperidine; hydrochlori...)
Show SMILES C(OCc1ccccc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H25NO/c1-3-7-18(8-4-1)15-21-13-11-20(12-14-21)17-22-16-19-9-5-2-6-10-19/h1-10,20H,11-17H2
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002293
PNG
(4-(4-Chloro-phenoxymethyl)-1-cyclopropylmethyl-pip...)
Show SMILES Clc1ccc(OCC2CCN(CC3CC3)CC2)cc1
Show InChI InChI=1S/C16H22ClNO/c17-15-3-5-16(6-4-15)19-12-14-7-9-18(10-8-14)11-13-1-2-13/h3-6,13-14H,1-2,7-12H2
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002260
PNG
(1-Cyclopropylmethyl-4-(2,4-dichloro-phenoxymethyl)...)
Show SMILES Clc1ccc(OCC2CCN(CC3CC3)CC2)c(Cl)c1
Show InChI InChI=1S/C16H21Cl2NO/c17-14-3-4-16(15(18)9-14)20-11-13-5-7-19(8-6-13)10-12-1-2-12/h3-4,9,12-13H,1-2,5-8,10-11H2
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50002194
PNG
(4-(4-Fluoro-benzyloxymethyl)-1-phenethyl-piperidin...)
Show SMILES Fc1ccc(COCC2CCN(CCc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H26FNO/c22-21-8-6-19(7-9-21)16-24-17-20-11-14-23(15-12-20)13-10-18-4-2-1-3-5-18/h1-9,20H,10-17H2
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4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for the mouse sigma opioid receptor


J Med Chem 35: 4344-61 (1992)


Article DOI: 10.1021/jm00101a012
BindingDB Entry DOI: 10.7270/Q28P614G
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312169
PNG
(US9604926, Compound CM-174 | US9724435, Compound C...)
Show SMILES CCc1ccc2oc(=O)n(CCCCN3CCN(CC3)C3CCCCC3)c2c1
Show InChI InChI=1S/C23H35N3O2/c1-2-19-10-11-22-21(18-19)26(23(27)28-22)13-7-6-12-24-14-16-25(17-15-24)20-8-4-3-5-9-20/h10-11,18,20H,2-9,12-17H2,1H3
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US Patent
4.04n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50353844
PNG
(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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4.17n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50353844
PNG
(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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UniChem

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Article
US Patent
4.17n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
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