BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1064 hits Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50252660
PNG
(Benzyl 1-(4-Cyano-2,3,5,6-tetrafluorophenyl)-6,7,8...)
Show SMILES Fc1cc2c(c(F)c1F)n(cc(C(=O)OCc1ccccc1)c2=O)-c1c(F)c(F)c(C#N)c(F)c1F
Show InChI InChI=1S/C24H9F7N2O3/c25-14-6-11-21(20(31)17(14)28)33(22-18(29)15(26)12(7-32)16(27)19(22)30)8-13(23(11)34)24(35)36-9-10-4-2-1-3-5-10/h1-6,8H,9H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 130n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis


J Med Chem 51: 4115-21 (2008)


Article DOI: 10.1021/jm701271y
BindingDB Entry DOI: 10.7270/Q2B27V3R
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50252612
PNG
(CHEMBL524195 | Ethyl 1-(4-Cyano-2,3,5,6-tetrafluor...)
Show SMILES CCOC(=O)c1cn(-c2c(F)c(F)c(C#N)c(F)c2F)c2c(F)c(F)c(F)cc2c1=O
Show InChI InChI=1S/C19H7F7N2O3/c1-2-31-19(30)8-5-28(16-6(18(8)29)3-9(20)12(23)15(16)26)17-13(24)10(21)7(4-27)11(22)14(17)25/h3,5H,2H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 170n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis


J Med Chem 51: 4115-21 (2008)


Article DOI: 10.1021/jm701271y
BindingDB Entry DOI: 10.7270/Q2B27V3R
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50252661
PNG
(1-(4-Cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-triflu...)
Show SMILES Fc1ccc(CNC(=O)c2cn(-c3c(F)c(F)c(C#N)c(F)c3F)c3c(F)c(F)c(F)cc3c2=O)cc1
Show InChI InChI=1S/C24H9F8N3O2/c25-10-3-1-9(2-4-10)7-34-24(37)13-8-35(21-11(23(13)36)5-14(26)17(29)20(21)32)22-18(30)15(27)12(6-33)16(28)19(22)31/h1-5,8H,7H2,(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 200n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis


J Med Chem 51: 4115-21 (2008)


Article DOI: 10.1021/jm701271y
BindingDB Entry DOI: 10.7270/Q2B27V3R
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50366601
PNG
(CHEMBL4171066)
Show SMILES CC(=O)c1cc2c(o1)-c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C14H8O4/c1-7(15)11-6-10-13(17)12(16)8-4-2-3-5-9(8)14(10)18-11/h2-6H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 800n/an/an/an/a



Westphalian Wilhelms University

Curated by ChEMBL


Assay Description
Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells assessed as reduction in ratio of phosphorylated STAT3 to total STAT3 level aft...


J Nat Prod 81: 1636-1644 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50366601
PNG
(CHEMBL4171066)
Show SMILES CC(=O)c1cc2c(o1)-c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C14H8O4/c1-7(15)11-6-10-13(17)12(16)8-4-2-3-5-9(8)14(10)18-11/h2-6H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 870n/an/an/an/a



Westphalian Wilhelms University

Curated by ChEMBL


Assay Description
Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 4 hrs by HTRF assay


J Nat Prod 81: 1636-1644 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450176
PNG
(CHEMBL4168778)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)C(=O)CC[C@@]12C
Show InChI InChI=1S/C28H44O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-23H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 990n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450156
PNG
(CHEMBL1933810)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C28H46O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-24,30H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,24-,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 1.18E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50366597
PNG
(2-Acetylfuranonaphthoquinone | BBI-608 | NAPABUCAS...)
Show SMILES CC(=O)c1cc2c(o1)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 1.90E+3n/an/an/an/a



Westphalian Wilhelms University

Curated by ChEMBL


Assay Description
Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells assessed as reduction in ratio of phosphorylated STAT3 to total STAT3 level aft...


J Nat Prod 81: 1636-1644 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450176
PNG
(CHEMBL4168778)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)C(=O)CC[C@@]12C
Show InChI InChI=1S/C28H44O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-23H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 1.97E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50366597
PNG
(2-Acetylfuranonaphthoquinone | BBI-608 | NAPABUCAS...)
Show SMILES CC(=O)c1cc2c(o1)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 2.00E+3n/an/an/an/a



Westphalian Wilhelms University

Curated by ChEMBL


Assay Description
Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 4 hrs by HTRF assay


J Nat Prod 81: 1636-1644 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450156
PNG
(CHEMBL1933810)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C28H46O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-24,30H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,24-,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 2.21E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450155
PNG
(CHEMBL4171438)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@@]3(CO3)[C@@H](C\C=C3/[C@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21-,22-,26+,27-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 2.23E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450150
PNG
(CHEMBL4163208)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@]3(CO3)[C@@H](C\C=C3/[C@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21-,22-,26+,27-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 2.55E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450155
PNG
(CHEMBL4171438)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@@]3(CO3)[C@@H](C\C=C3/[C@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21-,22-,26+,27-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 2.56E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450178
PNG
(CHEMBL360826)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@]2(CO2)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C22H32O7/c1-13(24)29-15-10-27-19(26)14(15)4-5-17-20(2)8-7-18(25)21(3,11-23)16(20)6-9-22(17)12-28-22/h4,15-18,23,25H,5-12H2,1-3H3/b14-4+/t15-,16+,17+,18-,20-,21+,22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 2.60E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450150
PNG
(CHEMBL4163208)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@]3(CO3)[C@@H](C\C=C3/[C@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21-,22-,26+,27-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 2.65E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50396177
PNG
(NIFUROXAZIDE)
Show SMILES Oc1ccc(cc1)C(=O)N\N=C\c1ccc(o1)[N+]([O-])=O
Show InChI InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibition of STAT3 expressed in human U3A cells after 1 hr by luciferase reporter gene assay


J Med Chem 55: 6645-68 (2012)


Article DOI: 10.1021/jm300207s
BindingDB Entry DOI: 10.7270/Q2CJ8FKK
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450178
PNG
(CHEMBL360826)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@]2(CO2)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C22H32O7/c1-13(24)29-15-10-27-19(26)14(15)4-5-17-20(2)8-7-18(25)21(3,11-23)16(20)6-9-22(17)12-28-22/h4,15-18,23,25H,5-12H2,1-3H3/b14-4+/t15-,16+,17+,18-,20-,21+,22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.04E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450146
PNG
(CHEMBL4167607)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C26H44O6Si/c1-23(2,3)33(6,7)32-18-14-30-22(29)17(18)8-9-20-24(4)12-11-21(28)25(5,15-27)19(24)10-13-26(20)16-31-26/h8,18-21,27-28H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,21-,24-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.05E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450148
PNG
(CHEMBL4162115)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C22H32O7/c1-13(24)29-15-10-27-19(26)14(15)4-5-17-20(2)8-7-18(25)21(3,11-23)16(20)6-9-22(17)12-28-22/h4,15-18,23,25H,5-12H2,1-3H3/b14-4+/t15-,16+,17+,18-,20-,21+,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.11E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450157
PNG
(CHEMBL4163992)
Show SMILES CC(=O)O[C@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C28H46O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-24,30H,1,10,12-17H2,2-9H3/b20-11+/t21-,22+,23+,24-,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.22E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450154
PNG
(CHEMBL4172126)
Show SMILES CC(C)(C)[Si](C)(C)OC[C@@]1(C)[C@H]2CCC(=C)[C@@H](C\C=C3/[C@H](O)COC3=O)[C@]2(C)CCC1=O
Show InChI InChI=1S/C26H42O5Si/c1-17-9-12-21-25(5,19(17)11-10-18-20(27)15-30-23(18)29)14-13-22(28)26(21,6)16-31-32(7,8)24(2,3)4/h10,19-21,27H,1,9,11-16H2,2-8H3/b18-10+/t19-,20-,21+,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.45E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450146
PNG
(CHEMBL4167607)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C26H44O6Si/c1-23(2,3)33(6,7)32-18-14-30-22(29)17(18)8-9-20-24(4)12-11-21(28)25(5,15-27)19(24)10-13-26(20)16-31-26/h8,18-21,27-28H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,21-,24-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.45E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450143
PNG
(CHEMBL4173895)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)C(=O)CC[C@@]12C
Show InChI InChI=1S/C26H42O6Si/c1-23(2,3)33(6,7)32-18-14-30-22(29)17(18)8-9-20-24(4)12-11-21(28)25(5,15-27)19(24)10-13-26(20)16-31-26/h8,18-20,27H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,24-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 3.95E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450144
PNG
(CHEMBL4171230)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)[C@]3(CO3)CC[C@@H]2[C@]1(C)CO
Show InChI InChI=1S/C26H44O6Si/c1-23(2,3)33(6,7)32-21-11-12-24(4)19(25(21,5)15-27)10-13-26(16-31-26)20(24)9-8-17-18(28)14-30-22(17)29/h8,18-21,27-28H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,21-,24-,25+,26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.16E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450156
PNG
(CHEMBL1933810)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C28H46O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-24,30H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,24-,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.33E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450140
PNG
(CHEMBL4162746)
Show SMILES CC(C)(C)[Si](C)(C)OC[C@@]1(C)[C@H]2CCC(=C)[C@@H](C\C=C3/[C@@H](O)COC3=O)[C@]2(C)CCC1=O
Show InChI InChI=1S/C26H42O5Si/c1-17-9-12-21-25(5,19(17)11-10-18-20(27)15-30-23(18)29)14-13-22(28)26(21,6)16-31-32(7,8)24(2,3)4/h10,19-21,27H,1,9,11-16H2,2-8H3/b18-10+/t19-,20+,21+,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.34E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450141
PNG
(CHEMBL4165560)
Show SMILES CC(C)(C)[Si](C)(C)OC[C@@]1(C)[C@H]2CC[C@]3(CO3)[C@@H](C\C=C3/[C@@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C32H56O6Si2/c1-28(2,3)39(9,10)37-20-31(8)24-15-18-32(21-36-32)25(30(24,7)17-16-26(31)33)14-13-22-23(19-35-27(22)34)38-40(11,12)29(4,5)6/h13,23-25H,14-21H2,1-12H3/b22-13+/t23-,24+,25+,30-,31+,32+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.40E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450176
PNG
(CHEMBL4168778)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)C(=O)CC[C@@]12C
Show InChI InChI=1S/C28H44O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-23H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.43E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450176
PNG
(CHEMBL4168778)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)C(=O)CC[C@@]12C
Show InChI InChI=1S/C28H44O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-23H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.57E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of NF-kappaB stimulated STAT3 activation in human HeLa cells incubated with NF-kappaB for 16 hrs followed by compound addition measured af...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50252610
PNG
(CHEMBL494257 | Ethyl 5,6,7,8-tetrafluoro-4-oxo-1-(...)
Show SMILES CCOC(=O)c1cn(-c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2c1=O
Show InChI InChI=1S/C18H6F9NO3/c1-2-31-18(30)4-3-28(16-13(26)10(23)8(21)11(24)14(16)27)15-5(17(4)29)6(19)7(20)9(22)12(15)25/h3H,2H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.60E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis


J Med Chem 51: 4115-21 (2008)


Article DOI: 10.1021/jm701271y
BindingDB Entry DOI: 10.7270/Q2B27V3R
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450140
PNG
(CHEMBL4162746)
Show SMILES CC(C)(C)[Si](C)(C)OC[C@@]1(C)[C@H]2CCC(=C)[C@@H](C\C=C3/[C@@H](O)COC3=O)[C@]2(C)CCC1=O
Show InChI InChI=1S/C26H42O5Si/c1-17-9-12-21-25(5,19(17)11-10-18-20(27)15-30-23(18)29)14-13-22(28)26(21,6)16-31-32(7,8)24(2,3)4/h10,19-21,27H,1,9,11-16H2,2-8H3/b18-10+/t19-,20+,21+,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.72E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450177
PNG
(CHEMBL4164249)
Show SMILES CC(=O)O[C@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)C(=O)CC[C@@]12C
Show InChI InChI=1S/C28H44O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-23H,1,10,12-17H2,2-9H3/b20-11+/t21-,22+,23+,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.75E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450177
PNG
(CHEMBL4164249)
Show SMILES CC(=O)O[C@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)C(=O)CC[C@@]12C
Show InChI InChI=1S/C28H44O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-23H,1,10,12-17H2,2-9H3/b20-11+/t21-,22+,23+,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 4.78E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450158
PNG
(CHEMBL1933811)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@@H](CC[C@@]12C)OC(C)=O
Show InChI InChI=1S/C30H48O7Si/c1-19-11-14-25-29(7,23(19)13-12-22-24(36-20(2)31)17-34-27(22)33)16-15-26(37-21(3)32)30(25,8)18-35-38(9,10)28(4,5)6/h12,23-26H,1,11,13-18H2,2-10H3/b22-12+/t23-,24-,25+,26-,29+,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.05E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450148
PNG
(CHEMBL4162115)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C22H32O7/c1-13(24)29-15-10-27-19(26)14(15)4-5-17-20(2)8-7-18(25)21(3,11-23)16(20)6-9-22(17)12-28-22/h4,15-18,23,25H,5-12H2,1-3H3/b14-4+/t15-,16+,17+,18-,20-,21+,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.11E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450149
PNG
(CHEMBL4169405)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@]3(CO3)[C@@H](C\C=C3/[C@@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21+,22+,26-,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.38E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450147
PNG
(CHEMBL4159896)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)[C@@]3(CO3)CC[C@@H]2[C@]1(C)CO
Show InChI InChI=1S/C26H44O6Si/c1-23(2,3)33(6,7)32-21-11-12-24(4)19(25(21,5)15-27)10-13-26(16-31-26)20(24)9-8-17-18(28)14-30-22(17)29/h8,18-21,27-28H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,21-,24-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.38E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450144
PNG
(CHEMBL4171230)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)[C@]3(CO3)CC[C@@H]2[C@]1(C)CO
Show InChI InChI=1S/C26H44O6Si/c1-23(2,3)33(6,7)32-21-11-12-24(4)19(25(21,5)15-27)10-13-26(16-31-26)20(24)9-8-17-18(28)14-30-22(17)29/h8,18-21,27-28H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,21-,24-,25+,26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.39E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450145
PNG
(CHEMBL4163576)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C26H44O5Si/c1-17-9-12-21-25(5,14-13-22(28)26(21,6)16-27)19(17)11-10-18-20(15-30-23(18)29)31-32(7,8)24(2,3)4/h10,19-22,27-28H,1,9,11-16H2,2-8H3/b18-10+/t19-,20-,21+,22-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.68E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450158
PNG
(CHEMBL1933811)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@@H](CC[C@@]12C)OC(C)=O
Show InChI InChI=1S/C30H48O7Si/c1-19-11-14-25-29(7,23(19)13-12-22-24(36-20(2)31)17-34-27(22)33)16-15-26(37-21(3)32)30(25,8)18-35-38(9,10)28(4,5)6/h12,23-26H,1,11,13-18H2,2-10H3/b22-12+/t23-,24-,25+,26-,29+,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.80E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450180
PNG
(CHEMBL4177253)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@@]3(CO3)[C@@H](C\C=C3/[C@@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21+,22+,26-,27+,28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.81E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450143
PNG
(CHEMBL4173895)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)C(=O)CC[C@@]12C
Show InChI InChI=1S/C26H42O6Si/c1-23(2,3)33(6,7)32-18-14-30-22(29)17(18)8-9-20-24(4)12-11-21(28)25(5,15-27)19(24)10-13-26(20)16-31-26/h8,18-20,27H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,24-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.90E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450143
PNG
(CHEMBL4173895)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1[C@@]2(CO2)CC[C@@H]2[C@](C)(CO)C(=O)CC[C@@]12C
Show InChI InChI=1S/C26H42O6Si/c1-23(2,3)33(6,7)32-18-14-30-22(29)17(18)8-9-20-24(4)12-11-21(28)25(5,15-27)19(24)10-13-26(20)16-31-26/h8,18-20,27H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,24-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 5.99E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450175
PNG
(CHEMBL4160465)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO)C(=O)CC[C@@]12C
Show InChI InChI=1S/C22H30O6/c1-13-5-8-18-21(3,10-9-19(25)22(18,4)12-23)16(13)7-6-15-17(28-14(2)24)11-27-20(15)26/h6,16-18,23H,1,5,7-12H2,2-4H3/b15-6+/t16-,17-,18+,21+,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 6.10E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450144
PNG
(CHEMBL4171230)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)[C@]3(CO3)CC[C@@H]2[C@]1(C)CO
Show InChI InChI=1S/C26H44O6Si/c1-23(2,3)33(6,7)32-21-11-12-24(4)19(25(21,5)15-27)10-13-26(16-31-26)20(24)9-8-17-18(28)14-30-22(17)29/h8,18-21,27-28H,9-16H2,1-7H3/b17-8+/t18-,19+,20+,21-,24-,25+,26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 6.15E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450154
PNG
(CHEMBL4172126)
Show SMILES CC(C)(C)[Si](C)(C)OC[C@@]1(C)[C@H]2CCC(=C)[C@@H](C\C=C3/[C@H](O)COC3=O)[C@]2(C)CCC1=O
Show InChI InChI=1S/C26H42O5Si/c1-17-9-12-21-25(5,19(17)11-10-18-20(27)15-30-23(18)29)14-13-22(28)26(21,6)16-31-32(7,8)24(2,3)4/h10,19-21,27H,1,9,11-16H2,2-8H3/b18-10+/t19-,20-,21+,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 6.45E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450145
PNG
(CHEMBL4163576)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C26H44O5Si/c1-17-9-12-21-25(5,14-13-22(28)26(21,6)16-27)19(17)11-10-18-20(15-30-23(18)29)31-32(7,8)24(2,3)4/h10,19-22,27-28H,1,9,11-16H2,2-8H3/b18-10+/t19-,20-,21+,22-,25+,26+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 6.57E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450156
PNG
(CHEMBL1933810)
Show SMILES CC(=O)O[C@@H]1COC(=O)\C1=C\C[C@@H]1C(=C)CC[C@@H]2[C@](C)(CO[Si](C)(C)C(C)(C)C)[C@H](O)CC[C@@]12C
Show InChI InChI=1S/C28H46O6Si/c1-18-10-13-23-27(6,21(18)12-11-20-22(34-19(2)29)16-32-25(20)31)15-14-24(30)28(23,7)17-33-35(8,9)26(3,4)5/h11,21-24,30H,1,10,12-17H2,2-9H3/b20-11+/t21-,22-,23+,24-,27+,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 6.92E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50450155
PNG
(CHEMBL4171438)
Show SMILES CC(=O)OC[C@@]1(C)[C@H]2CC[C@@]3(CO3)[C@@H](C\C=C3/[C@H](COC3=O)O[Si](C)(C)C(C)(C)C)[C@]2(C)CCC1=O
Show InChI InChI=1S/C28H44O7Si/c1-18(29)33-16-27(6)21-11-14-28(17-34-28)22(26(21,5)13-12-23(27)30)10-9-19-20(15-32-24(19)31)35-36(7,8)25(2,3)4/h9,20-22H,10-17H2,1-8H3/b19-9+/t20-,21-,22-,26+,27-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
PubMed
n/an/an/an/a 7.05E+3n/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of NF-kappaB stimulated STAT3 activation in human HeLa cells incubated with NF-kappaB for 16 hrs followed by compound addition measured af...


Bioorg Med Chem 26: 5053-5061 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1064 total )  |  Next  |  Last  >>
Jump to: