BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 220 hits Enz. Inhib. hit(s) with Target = 'Sodium channel alpha subunits; brain (Types I, II, III)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel alpha subunits; brain (Types I, II, III)


(Homo sapiens (Human))
BDBM50233221
PNG
(CHEMBL4064160)
Show SMILES CCCCCCCCCC[C@H]1NC(=N)N[C@@]2(CCCO2)[C@H]1C(O)=O
Show InChI InChI=1S/C18H33N3O3/c1-2-3-4-5-6-7-8-9-11-14-15(16(22)23)18(12-10-13-24-18)21-17(19)20-14/h14-15H,2-13H2,1H3,(H,22,23)(H3,19,20,21)/t14-,15-,18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 5.30n/an/an/an/a



Tohoku University

Curated by ChEMBL


Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay


Bioorg Med Chem Lett 27: 1247-1251 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.054
More data for this
Ligand-Target Pair
Sodium channel alpha subunits; brain (Types I, II, III)


(Homo sapiens (Human))
BDBM50233223
PNG
(CHEMBL4060338)
Show SMILES CCCCCCCCCC[C@@H]1C[C@]2(CCCO2)NC(=N)N1
Show InChI InChI=1S/C17H33N3O/c1-2-3-4-5-6-7-8-9-11-15-14-17(12-10-13-21-17)20-16(18)19-15/h15H,2-14H2,1H3,(H3,18,19,20)/t15-,17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Tohoku University

Curated by ChEMBL


Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay


Bioorg Med Chem Lett 27: 1247-1251 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.054
More data for this
Ligand-Target Pair
Sodium channel alpha subunits; brain (Types I, II, III)


(Homo sapiens (Human))
BDBM50233222
PNG
(CHEMBL4082248)
Show SMILES CCCCCCCCCC[C@@H]1NC(=N)N[C@]2(CCCO2)[C@@H]1C(O)=O
Show InChI InChI=1S/C18H33N3O3/c1-2-3-4-5-6-7-8-9-11-14-15(16(22)23)18(12-10-13-24-18)21-17(19)20-14/h14-15H,2-13H2,1H3,(H,22,23)(H3,19,20,21)/t14-,15-,18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 79n/an/an/an/a



Tohoku University

Curated by ChEMBL


Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay


Bioorg Med Chem Lett 27: 1247-1251 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.054
More data for this
Ligand-Target Pair
Sodium channel alpha subunits; brain (Types I, II, III)


(Homo sapiens (Human))
BDBM50233224
PNG
(CHEMBL4070670)
Show SMILES CCCCCCCCCC[C@H]1C[C@@]2(CCCO2)NC(=N)N1
Show InChI InChI=1S/C17H33N3O/c1-2-3-4-5-6-7-8-9-11-15-14-17(12-10-13-21-17)20-16(18)19-15/h15H,2-14H2,1H3,(H3,18,19,20)/t15-,17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 120n/an/an/an/a



Tohoku University

Curated by ChEMBL


Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay


Bioorg Med Chem Lett 27: 1247-1251 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.054
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.20E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.90E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM168436
PNG
(US9675591, SKA-19)
Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7.90E+3n/an/a7.3525



The Regents of the University of California

US Patent


Assay Description
All experiments were conducted at room temperature (22-24 C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...


US Patent US9675591 (2017)


BindingDB Entry DOI: 10.7270/Q26T0JSP
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50171290
PNG
(5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl...)
Show SMILES CCc1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 310: 905-14 (2004)


Article DOI: 10.1124/jpet.104.067884
BindingDB Entry DOI: 10.7270/Q2RR1WTX
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50171290
PNG
(5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl...)
Show SMILES CCc1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 310: 905-14 (2004)


Article DOI: 10.1124/jpet.104.067884
BindingDB Entry DOI: 10.7270/Q2RR1WTX
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM21280
PNG
(5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1
Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22?,27?,29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Sanofi Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 284: 644-50 (1998)


Article DOI: 10.1021/acschembio.5b00817
BindingDB Entry DOI: 10.7270/Q2D50KHT
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM21280
PNG
(5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1
Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22?,27?,29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Sanofi Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 284: 644-50 (1998)


Article DOI: 10.1021/acschembio.5b00817
BindingDB Entry DOI: 10.7270/Q2D50KHT
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)


BindingDB Entry DOI: 10.7270/Q237777N
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)


BindingDB Entry DOI: 10.7270/Q237777N
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM190575
PNG
(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Show SMILES FC(F)(F)c1ccc(SCC(=O)N2CCCc3ccccc23)nc1
Show InChI InChI=1S/C17H15F3N2OS/c18-17(19,20)13-7-8-15(21-10-13)24-11-16(23)22-9-3-5-12-4-1-2-6-14(12)22/h1-2,4,6-8,10H,3,5,9,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...


US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM190576
PNG
(US9181219, 6)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-4-2-5-13-6-3-9-23(17(12)13)16(24)11-25-15-8-7-14(10-22-15)18(19,20)21/h2,4-5,7-8,10H,3,6,9,11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...


US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM190578
PNG
(US9181219, 16)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Cl)cn3)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...


US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM190579
PNG
(US9181219, 20)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-5-2-6-13-7-4-10-20(16(12)13)15(21)11-22-17-14(18)8-3-9-19-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...


US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130533
PNG
(CHEMBL3632693)
Show SMILES COc1cc(ccc1OCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Show InChI InChI=1S/C24H27F3N2O4/c1-32-22-12-17(24(25,26)27)6-7-21(22)33-15-19(30)14-28-10-8-18(9-11-28)29-13-16-4-2-3-5-20(16)23(29)31/h2-7,12,18-19,30H,8-11,13-15H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 910n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.005
BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50130536
PNG
(CHEMBL3632696)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCC(CC1)NC(=O)c1ccccc1
Show InChI InChI=1S/C22H25F3N2O3/c23-22(24,25)17-6-8-20(9-7-17)30-15-19(28)14-27-12-10-18(11-13-27)26-21(29)16-4-2-1-3-5-16/h1-9,18-19,28H,10-15H2,(H,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay


Bioorg Med Chem Lett 25: 5419-23 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.005
BindingDB Entry DOI: 10.7270/Q2930W06
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50344821
PNG
(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Show SMILES NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO
Show InChI InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated Na channel 1.3 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50344821
PNG
(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Show SMILES NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO
Show InChI InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated Na channel 1.1 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50344821
PNG
(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Show SMILES NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO
Show InChI InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated Na channel 1.2 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.53E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.54E+3n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.55E+3n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.1 (Nav1.1)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.50E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.41E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.60E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.54E+3n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.70E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50008745
PNG
(CHEMBL3236329)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
Show InChI InChI=1S/C23H18F3N7O3/c24-23(25,26)35-16-5-3-4-15(12-16)21(34)28-13-19-29-22(36-31-19)20-17-6-1-2-7-18(17)30-33(20)11-10-32-9-8-27-14-32/h1-9,12,14H,10-11,13H2,(H,28,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.76E+3n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50008746
PNG
(CHEMBL3236343)
Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay


J Med Chem 57: 2942-52 (2014)


Article DOI: 10.1021/jm401881q
BindingDB Entry DOI: 10.7270/Q2CZ38QJ
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3)


(Homo sapiens (Human))
BDBM50349984
PNG
(CHEMBL1813048)
Show SMILES CC(=O)Nc1cccc(Nc2ncnc(n2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
Show InChI InChI=1S/C25H27F3N6O3/c1-16-21(31-17(2)35)4-3-5-22(16)32-23-29-15-30-24(33-23)34-12-10-19(11-13-34)36-14-18-6-8-20(9-7-18)37-25(26,27)28/h3-9,15,19H,10-14H2,1-2H3,(H,31,35)(H,29,30,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of 20% inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological a...


J Med Chem 54: 4427-45 (2011)


Article DOI: 10.1021/jm200018k
BindingDB Entry DOI: 10.7270/Q2N016W1
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107018
PNG
(CHEMBL108070 | N-(4-Methyl-benzoyl)-N'-(2-thiophen...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCc1cccs1
Show InChI InChI=1S/C15H17N3OS/c1-11-4-6-12(7-5-11)14(19)18-15(16)17-9-8-13-3-2-10-20-13/h2-7,10H,8-9H2,1H3,(H3,16,17,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.95E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107019
PNG
(CHEMBL432963 | N-Butyl-N'-(4-methyl-benzoyl)-guani...)
Show SMILES CCCCN=C(N)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C13H19N3O/c1-3-4-9-15-13(14)16-12(17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H3,14,15,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.74E+4n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107017
PNG
(CHEMBL108782 | N-(4-Methyl-benzoyl)-N'-(3-phenoxy-...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCCOc1ccccc1
Show InChI InChI=1S/C18H21N3O2/c1-14-8-10-15(11-9-14)17(22)21-18(19)20-12-5-13-23-16-6-3-2-4-7-16/h2-4,6-11H,5,12-13H2,1H3,(H3,19,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2.67E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107022
PNG
(CHEMBL110409 | N-[1-Amino-1-(7-trifluoromethyl-3,4...)
Show SMILES Cc1ccc(cc1)C(=O)NC(=N)N1CCCc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-12-4-6-14(7-5-12)17(26)24-18(23)25-10-2-3-13-8-9-15(11-16(13)25)19(20,21)22/h4-9,11H,2-3,10H2,1H3,(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107023
PNG
(CHEMBL320248 | N-(2-Benzylsulfanyl-ethyl)-N'-(4-me...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCSCc1ccccc1
Show InChI InChI=1S/C18H21N3OS/c1-14-7-9-16(10-8-14)17(22)21-18(19)20-11-12-23-13-15-5-3-2-4-6-15/h2-10H,11-13H2,1H3,(H3,19,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107028
PNG
(CHEMBL109127 | N-(Furan-2-carbonyl)-N'-(4-phenyl-b...)
Show SMILES NC(NC(=O)c1ccco1)=NCCCCc1ccccc1
Show InChI InChI=1S/C16H19N3O2/c17-16(19-15(20)14-10-6-12-21-14)18-11-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10,12H,4-5,9,11H2,(H3,17,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.38E+4n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107027
PNG
(CHEMBL320314 | N-[2-(4-Methoxy-1H-indol-3-yl)-ethy...)
Show SMILES COc1cccc2[nH]cc(CCN=C(N)NC(=O)c3ccc(C)cc3)c12
Show InChI InChI=1S/C20H22N4O2/c1-13-6-8-14(9-7-13)19(25)24-20(21)22-11-10-15-12-23-16-4-3-5-17(26-2)18(15)16/h3-9,12,23H,10-11H2,1-2H3,(H3,21,22,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.35E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107030
PNG
(CHEMBL106459 | N-(2-Methyl-benzoyl)-N'-(4-phenyl-b...)
Show SMILES Cc1ccccc1C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-15-9-5-6-13-17(15)18(23)22-19(20)21-14-8-7-12-16-10-3-2-4-11-16/h2-6,9-11,13H,7-8,12,14H2,1H3,(H3,20,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107033
PNG
(CHEMBL106434 | N-(2,5-Dibromo-phenyl)-N'-(4-methyl...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=Nc1cc(Br)ccc1Br
Show InChI InChI=1S/C15H13Br2N3O/c1-9-2-4-10(5-3-9)14(21)20-15(18)19-13-8-11(16)6-7-12(13)17/h2-8H,1H3,(H3,18,19,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00644-8
BindingDB Entry DOI: 10.7270/Q2PC31P4
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 220 total )  |  Next  |  Last  >>
Jump to: